SNTG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the syntrophin family. Syntrophins are cytoplasmic peripheral membrane proteins that typically contain 2 pleckstrin homology (PH) domains, a PDZ domain that bisects the first PH domain, and a C-terminal domain that mediates dystrophin binding. This family member plays a role in mediating gamma-enolase trafficking to the plasma membrane and in enhancing its neurotrophic activity. Mutations in this gene are associated with idiopathic scoliosis. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.90371664
2vocalization behavior (GO:0071625)5.89928262
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.65412292
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.40036422
5presynaptic membrane assembly (GO:0097105)5.35587035
6regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.32649623
7protein localization to synapse (GO:0035418)5.23642682
8regulation of short-term neuronal synaptic plasticity (GO:0048172)5.23355638
9regulation of glutamate receptor signaling pathway (GO:1900449)5.11446646
10synaptic vesicle exocytosis (GO:0016079)5.04501047
11neurotransmitter-gated ion channel clustering (GO:0072578)4.97660054
12presynaptic membrane organization (GO:0097090)4.81450892
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.80086123
14regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.69069030
15postsynaptic membrane organization (GO:0001941)4.63533780
16neuronal action potential propagation (GO:0019227)4.62858922
17glutamate receptor signaling pathway (GO:0007215)4.52016738
18startle response (GO:0001964)4.50778517
19glutamate secretion (GO:0014047)4.44058997
20neuron-neuron synaptic transmission (GO:0007270)4.41719394
21synaptic transmission, glutamatergic (GO:0035249)4.34213892
22regulation of synaptic vesicle exocytosis (GO:2000300)4.32589994
23negative regulation of synaptic transmission, GABAergic (GO:0032229)4.31940379
24gamma-aminobutyric acid signaling pathway (GO:0007214)4.18437202
25locomotory exploration behavior (GO:0035641)4.18382085
26synaptic vesicle docking involved in exocytosis (GO:0016081)4.15658668
27neurotransmitter secretion (GO:0007269)4.13761930
28response to histamine (GO:0034776)4.02170987
29pyrimidine nucleobase catabolic process (GO:0006208)4.00422770
30C4-dicarboxylate transport (GO:0015740)3.96845751
31regulation of excitatory postsynaptic membrane potential (GO:0060079)3.93440653
32positive regulation of synapse maturation (GO:0090129)3.87820351
33regulation of synaptic transmission, glutamatergic (GO:0051966)3.87066932
34positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.86504573
35neuron recognition (GO:0008038)3.85504034
36regulation of synaptic vesicle transport (GO:1902803)3.81014438
37regulation of postsynaptic membrane potential (GO:0060078)3.80567793
38positive regulation of membrane potential (GO:0045838)3.78589561
39positive regulation of synapse assembly (GO:0051965)3.77611515
40regulation of long-term neuronal synaptic plasticity (GO:0048169)3.77403655
41behavioral response to nicotine (GO:0035095)3.74502757
42long-term synaptic potentiation (GO:0060291)3.69733212
43G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.67955327
44exploration behavior (GO:0035640)3.66100625
45gamma-aminobutyric acid transport (GO:0015812)3.65409047
46behavioral response to cocaine (GO:0048148)3.63326528
47negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.62919554
48synaptic vesicle maturation (GO:0016188)3.60902993
49nonmotile primary cilium assembly (GO:0035058)3.58952493
50negative regulation of cytosolic calcium ion concentration (GO:0051481)3.58484595
51regulation of neuronal synaptic plasticity (GO:0048168)3.57591273
52regulation of synapse maturation (GO:0090128)3.56416068
53nucleobase catabolic process (GO:0046113)3.56117178
54membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.53176385
55righting reflex (GO:0060013)3.49404038
56mechanosensory behavior (GO:0007638)3.48883376
57regulation of action potential (GO:0098900)3.48508943
58long-term memory (GO:0007616)3.48326323
59cerebellar granule cell differentiation (GO:0021707)3.43496734
60fucose catabolic process (GO:0019317)3.40063915
61L-fucose metabolic process (GO:0042354)3.40063915
62L-fucose catabolic process (GO:0042355)3.40063915
63positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.39592981
64behavioral fear response (GO:0001662)3.38586924
65behavioral defense response (GO:0002209)3.38586924
66membrane hyperpolarization (GO:0060081)3.38524749
67neurotransmitter transport (GO:0006836)3.38023286
68detection of calcium ion (GO:0005513)3.36387827
69regulation of synapse structural plasticity (GO:0051823)3.32411200
70positive regulation of action potential (GO:0045760)3.28908256
71regulation of synaptic plasticity (GO:0048167)3.28543122
72fear response (GO:0042596)3.28459462
73auditory behavior (GO:0031223)3.28393589
74proline transport (GO:0015824)3.28301997
75regulation of glutamate secretion (GO:0014048)3.28268349
76transmission of nerve impulse (GO:0019226)3.27527823
77detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.27258990
78positive regulation of synaptic transmission, GABAergic (GO:0032230)3.26918567
79neuronal action potential (GO:0019228)3.26439747
80regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.25570653
81axonal fasciculation (GO:0007413)3.24634152
82membrane depolarization (GO:0051899)3.24245276
83cerebellar Purkinje cell differentiation (GO:0021702)3.24016542
84water-soluble vitamin biosynthetic process (GO:0042364)3.20129147
85regulation of neurotransmitter secretion (GO:0046928)3.20020673
86regulation of synapse assembly (GO:0051963)3.17035145
87detection of light stimulus involved in visual perception (GO:0050908)3.14642259
88detection of light stimulus involved in sensory perception (GO:0050962)3.14642259
89transferrin transport (GO:0033572)3.13526640
90glycosphingolipid biosynthetic process (GO:0006688)3.12495378
91protein polyglutamylation (GO:0018095)3.12396188
92response to pheromone (GO:0019236)3.12225055
93regulation of respiratory system process (GO:0044065)3.10593800
94regulation of dendritic spine morphogenesis (GO:0061001)3.10567070
95learning (GO:0007612)3.10259527
96regulation of synaptic transmission, GABAergic (GO:0032228)3.09610517
97regulation of cilium movement (GO:0003352)3.07889606
98regulation of neurotransmitter levels (GO:0001505)3.07186348
99positive regulation of neurotransmitter transport (GO:0051590)3.06530591
100synaptic vesicle endocytosis (GO:0048488)3.05288631
101axoneme assembly (GO:0035082)3.05251373
102regulation of vesicle fusion (GO:0031338)3.03724425
103response to auditory stimulus (GO:0010996)3.03195248
104reflex (GO:0060004)3.02673442
105positive regulation of synaptic transmission (GO:0050806)3.01430742
106synaptic transmission (GO:0007268)3.00777493
107synapse assembly (GO:0007416)2.99173373
108positive regulation of neurotransmitter secretion (GO:0001956)2.95562178
109membrane depolarization during action potential (GO:0086010)2.95461535
110negative regulation of dendrite development (GO:2000171)2.93987585
111positive regulation of dendritic spine morphogenesis (GO:0061003)2.93786971
112energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.93463736
113ATP hydrolysis coupled proton transport (GO:0015991)2.93463736
114trivalent inorganic cation transport (GO:0072512)2.93035358
115ferric iron transport (GO:0015682)2.93035358
116tachykinin receptor signaling pathway (GO:0007217)2.92792999
117dendritic spine morphogenesis (GO:0060997)2.91572651
118regulation of dendritic spine development (GO:0060998)2.91255490
119serotonin metabolic process (GO:0042428)2.90775025
120epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.90620015
121regulation of synaptic transmission (GO:0050804)2.89340796
122protein localization to cilium (GO:0061512)2.89210981
123regulation of neurotransmitter transport (GO:0051588)2.89009612
124cellular ketone body metabolic process (GO:0046950)2.88174272
125negative regulation of dendrite morphogenesis (GO:0050774)2.87727137
126retinal cone cell development (GO:0046549)2.87099241
127protein-cofactor linkage (GO:0018065)2.86878101
128negative regulation of neurotransmitter transport (GO:0051589)2.86790930
129regulation of synapse organization (GO:0050807)2.86582088
130behavioral response to ethanol (GO:0048149)2.85062548
131glycerophospholipid catabolic process (GO:0046475)2.83434868
132epithelial cilium movement (GO:0003351)2.82735631
133primary amino compound metabolic process (GO:1901160)2.77844054
134atrial cardiac muscle cell action potential (GO:0086014)2.67413816
135platelet dense granule organization (GO:0060155)2.66413148
136cilium morphogenesis (GO:0060271)2.65315943
137action potential (GO:0001508)2.64891241
138regulation of neurotransmitter uptake (GO:0051580)2.63877704
139inner ear receptor stereocilium organization (GO:0060122)2.63254386
140limb bud formation (GO:0060174)2.62222013
141ketone body metabolic process (GO:1902224)2.61161523
142indolalkylamine metabolic process (GO:0006586)2.60447078
143kynurenine metabolic process (GO:0070189)2.59469297
144photoreceptor cell maintenance (GO:0045494)2.58765773
145auditory receptor cell stereocilium organization (GO:0060088)2.58020587
146positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.57276697
147regulation of microtubule-based movement (GO:0060632)2.55831152
148somite development (GO:0061053)2.54515172
149inositol phosphate catabolic process (GO:0071545)2.54129421
150cilium organization (GO:0044782)2.53373306
151establishment of protein localization to Golgi (GO:0072600)2.52742427
152synaptic transmission, cholinergic (GO:0007271)2.52571107
153negative regulation of telomere maintenance (GO:0032205)2.52131709
154negative regulation of heart rate (GO:0010459)2.50883608
155DNA double-strand break processing (GO:0000729)2.48264084
156indole-containing compound metabolic process (GO:0042430)2.47717522
157cAMP catabolic process (GO:0006198)2.46522436
158positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.46487316
159detection of mechanical stimulus involved in sensory perception (GO:0050974)2.46308333
160cilium assembly (GO:0042384)2.44251971
161negative regulation of oligodendrocyte differentiation (GO:0048715)2.42099611
162cyclic nucleotide catabolic process (GO:0009214)2.41934251
163indolalkylamine catabolic process (GO:0046218)2.41894108

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.94315073
2GBX2_23144817_ChIP-Seq_PC3_Human4.70724882
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.00711549
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.92677453
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.85708513
6TAF15_26573619_Chip-Seq_HEK293_Human2.76167378
7* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54353751
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.46085749
9* REST_21632747_ChIP-Seq_MESCs_Mouse2.45587058
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.43968985
11* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37193728
12* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.37178367
13* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.37178367
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.36964564
15* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36266298
16* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.31064084
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.30542370
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.30384671
19CTBP1_25329375_ChIP-Seq_LNCAP_Human2.19566551
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.18361027
21* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.16779930
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.00390615
23SALL1_21062744_ChIP-ChIP_HESCs_Human1.98727421
24* EZH2_27294783_Chip-Seq_ESCs_Mouse1.97656353
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97157611
26* RNF2_27304074_Chip-Seq_ESCs_Mouse1.95022156
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.94122835
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.92065788
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.91374355
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.89674022
31* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.87329963
32* SMAD4_21799915_ChIP-Seq_A2780_Human1.86477305
33* P300_19829295_ChIP-Seq_ESCs_Human1.86061528
34* REST_18959480_ChIP-ChIP_MESCs_Mouse1.86019363
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.85739569
36DROSHA_22980978_ChIP-Seq_HELA_Human1.83295391
37* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82447035
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81743529
39* RARB_27405468_Chip-Seq_BRAIN_Mouse1.78932352
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.77144315
41AR_21572438_ChIP-Seq_LNCaP_Human1.75997203
42* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72795793
43IGF1R_20145208_ChIP-Seq_DFB_Human1.68003113
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.66186758
45* FUS_26573619_Chip-Seq_HEK293_Human1.64042196
46VDR_22108803_ChIP-Seq_LS180_Human1.55040045
47* PIAS1_25552417_ChIP-Seq_VCAP_Human1.54615890
48* SMAD3_21741376_ChIP-Seq_EPCs_Human1.53052929
49RNF2_27304074_Chip-Seq_NSC_Mouse1.48428005
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.48325377
51* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48121192
52ZNF274_21170338_ChIP-Seq_K562_Hela1.45602104
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45455490
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44819575
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43064510
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42809365
57AR_25329375_ChIP-Seq_VCAP_Human1.42042297
58CBP_20019798_ChIP-Seq_JUKART_Human1.38431370
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38431370
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.35889679
61SOX2_21211035_ChIP-Seq_LN229_Gbm1.35805482
62* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35060133
63STAT3_23295773_ChIP-Seq_U87_Human1.34862805
64MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34205160
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33639900
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32802484
67TP53_22573176_ChIP-Seq_HFKS_Human1.31811998
68ER_23166858_ChIP-Seq_MCF-7_Human1.28504106
69* NANOG_18555785_Chip-Seq_ESCs_Mouse1.28365700
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27044373
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26923442
72* TCF4_23295773_ChIP-Seq_U87_Human1.25735855
73E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.23939819
74* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23085157
75* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21988697
76KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20775810
77NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20197973
78TCF4_22108803_ChIP-Seq_LS180_Human1.20196217
79* ARNT_22903824_ChIP-Seq_MCF-7_Human1.19996041
80* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19612255
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.19460425
82RUNX2_22187159_ChIP-Seq_PCA_Human1.18953922
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18001851
84SOX2_19829295_ChIP-Seq_ESCs_Human1.15870085
85NANOG_19829295_ChIP-Seq_ESCs_Human1.15870085
86* FLI1_27457419_Chip-Seq_LIVER_Mouse1.14881828
87EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13694929
88* EZH2_27294783_Chip-Seq_NPCs_Mouse1.13405956
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13065698
90TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12501214
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12501214
92* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12260063
93* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12015088
94IRF1_19129219_ChIP-ChIP_H3396_Human1.11255773
95* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10340165
96* AR_19668381_ChIP-Seq_PC3_Human1.09641954
97BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.09332202
98* P53_22387025_ChIP-Seq_ESCs_Mouse1.09223259
99JUN_21703547_ChIP-Seq_K562_Human1.08797909
100* TAL1_26923725_Chip-Seq_HPCs_Mouse1.08663491
101* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07734351
102* E2F1_18555785_Chip-Seq_ESCs_Mouse1.07568139
103CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07285633
104* AHR_22903824_ChIP-Seq_MCF-7_Human1.06715631
105ERG_21242973_ChIP-ChIP_JURKAT_Human1.06566468
106TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06037165
107* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05556568
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05466829
109* NFE2_27457419_Chip-Seq_LIVER_Mouse1.05322380
110MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04811345
111YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04442160
112SMAD4_21741376_ChIP-Seq_EPCs_Human1.04082767
113PRDM14_20953172_ChIP-Seq_ESCs_Human1.03634891
114MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03480500
115NOTCH1_21737748_ChIP-Seq_TLL_Human1.03402306
116MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03275392
117* RING1B_27294783_Chip-Seq_ESCs_Mouse1.03086488
118P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02572724
119RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02370151
120TP53_18474530_ChIP-ChIP_U2OS_Human1.00953865
121* KDM2B_26808549_Chip-Seq_REH_Human1.00858756
122* CMYC_18555785_Chip-Seq_ESCs_Mouse1.00253587
123ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99446326
124CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99213602
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96539006
126EWS_26573619_Chip-Seq_HEK293_Human0.96154245
127* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96120870
128BCAT_22108803_ChIP-Seq_LS180_Human0.95385815
129PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94104090

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.26035372
2MP0004859_abnormal_synaptic_plasticity5.14248402
3MP0003635_abnormal_synaptic_transmissio3.85737180
4MP0009745_abnormal_behavioral_response3.51764577
5MP0002063_abnormal_learning/memory/cond3.22204493
6MP0002064_seizures3.19621423
7MP0009046_muscle_twitch3.17903040
8MP0002822_catalepsy3.17528948
9MP0002572_abnormal_emotion/affect_behav2.99527872
10MP0004270_analgesia2.97959251
11MP0001968_abnormal_touch/_nociception2.87931271
12MP0002272_abnormal_nervous_system2.63393072
13MP0001486_abnormal_startle_reflex2.62539215
14MP0001501_abnormal_sleep_pattern2.54036179
15MP0002735_abnormal_chemical_nociception2.53532406
16MP0005646_abnormal_pituitary_gland2.45958370
17MP0003787_abnormal_imprinting2.38052574
18MP0002736_abnormal_nociception_after2.37277733
19MP0002734_abnormal_mechanical_nocicepti2.29225866
20MP0005423_abnormal_somatic_nervous2.26825465
21MP0006276_abnormal_autonomic_nervous2.18851233
22MP0002067_abnormal_sensory_capabilities2.11095142
23MP0001440_abnormal_grooming_behavior2.06827842
24MP0009780_abnormal_chondrocyte_physiolo2.04777991
25MP0003122_maternal_imprinting1.91609699
26MP0002557_abnormal_social/conspecific_i1.90644155
27MP0003879_abnormal_hair_cell1.86890719
28MP0001188_hyperpigmentation1.85276726
29MP0001529_abnormal_vocalization1.84079066
30MP0002733_abnormal_thermal_nociception1.83060005
31MP0001970_abnormal_pain_threshold1.79766980
32MP0002184_abnormal_innervation1.77946614
33MP0001984_abnormal_olfaction1.77925878
34MP0004924_abnormal_behavior1.76873770
35MP0005386_behavior/neurological_phenoty1.76873770
36MP0000778_abnormal_nervous_system1.71689843
37MP0000569_abnormal_digit_pigmentation1.64426327
38MP0005645_abnormal_hypothalamus_physiol1.62206811
39MP0003195_calcinosis1.56424457
40MP0001905_abnormal_dopamine_level1.54834780
41MP0010386_abnormal_urinary_bladder1.51499776
42MP0008569_lethality_at_weaning1.50862497
43MP0002909_abnormal_adrenal_gland1.48107930
44MP0004142_abnormal_muscle_tone1.46833470
45MP0004811_abnormal_neuron_physiology1.41560975
46MP0002876_abnormal_thyroid_physiology1.39578214
47MP0002837_dystrophic_cardiac_calcinosis1.39445047
48MP0000955_abnormal_spinal_cord1.32407609
49MP0002066_abnormal_motor_capabilities/c1.32030112
50MP0001502_abnormal_circadian_rhythm1.29888563
51MP0002882_abnormal_neuron_morphology1.27309946
52MP0004133_heterotaxia1.25177440
53MP0003329_amyloid_beta_deposits1.24401324
54MP0003011_delayed_dark_adaptation1.22328115
55MP0002653_abnormal_ependyma_morphology1.17863228
56MP0003136_yellow_coat_color1.15874759
57MP0003283_abnormal_digestive_organ1.12962440
58MP0004043_abnormal_pH_regulation1.12850678
59MP0000427_abnormal_hair_cycle1.11618875
60MP0005084_abnormal_gallbladder_morpholo1.10052437
61MP0001963_abnormal_hearing_physiology1.09383878
62MP0003633_abnormal_nervous_system1.09221147
63MP0002928_abnormal_bile_duct1.06489857
64MP0005551_abnormal_eye_electrophysiolog1.05752581
65MP0002751_abnormal_autonomic_nervous1.05203548
66MP0002638_abnormal_pupillary_reflex1.02481429
67MP0005171_absent_coat_pigmentation1.02086341
68MP0002069_abnormal_eating/drinking_beha0.98496591
69MP0000631_abnormal_neuroendocrine_gland0.97582000
70MP0002152_abnormal_brain_morphology0.97171037
71MP0004742_abnormal_vestibular_system0.96525437
72MP0004147_increased_porphyrin_level0.95928608
73MP0003631_nervous_system_phenotype0.95784141
74MP0003121_genomic_imprinting0.94943337
75MP0006292_abnormal_olfactory_placode0.94022283
76MP0005195_abnormal_posterior_eye0.93415151
77MP0004858_abnormal_nervous_system0.92356674
78MP0008789_abnormal_olfactory_epithelium0.92061870
79MP0005187_abnormal_penis_morphology0.88626971
80MP0004885_abnormal_endolymph0.88476581
81MP0001986_abnormal_taste_sensitivity0.87556100
82MP0002229_neurodegeneration0.86955768
83MP0008875_abnormal_xenobiotic_pharmacok0.85898086
84MP0005409_darkened_coat_color0.84481391
85MP0004085_abnormal_heartbeat0.84154732
86MP0001919_abnormal_reproductive_system0.82921866
87MP0008877_abnormal_DNA_methylation0.82849020
88MP0000013_abnormal_adipose_tissue0.81424426
89MP0005394_taste/olfaction_phenotype0.81026443
90MP0005499_abnormal_olfactory_system0.81026443
91MP0000026_abnormal_inner_ear0.80743275
92MP0001664_abnormal_digestion0.80661473
93MP0005174_abnormal_tail_pigmentation0.80175069
94MP0000751_myopathy0.78602135
95MP0002234_abnormal_pharynx_morphology0.78521416
96MP0005535_abnormal_body_temperature0.78123903
97MP0000049_abnormal_middle_ear0.77842343
98MP0003119_abnormal_digestive_system0.77427435
99MP0002752_abnormal_somatic_nervous0.76801720
100MP0000383_abnormal_hair_follicle0.76432349
101MP0005389_reproductive_system_phenotype0.75330091
102MP0003183_abnormal_peptide_metabolism0.72862104
103MP0008874_decreased_physiological_sensi0.71471509
104MP0008872_abnormal_physiological_respon0.69892601
105MP0005379_endocrine/exocrine_gland_phen0.69366124
106MP0002102_abnormal_ear_morphology0.68908660
107MP0001485_abnormal_pinna_reflex0.68511057
108MP0001177_atelectasis0.66523153
109MP0004145_abnormal_muscle_electrophysio0.66219900
110MP0003938_abnormal_ear_development0.65387691
111MP0004215_abnormal_myocardial_fiber0.65257023
112MP0003632_abnormal_nervous_system0.65042119
113MP0006072_abnormal_retinal_apoptosis0.64582908
114MP0001943_abnormal_respiration0.56966681
115MP0003634_abnormal_glial_cell0.55418463
116MP0000678_abnormal_parathyroid_gland0.54912833
117MP0010770_preweaning_lethality0.54122367
118MP0002082_postnatal_lethality0.54122367
119MP0005253_abnormal_eye_physiology0.52926455
120MP0003137_abnormal_impulse_conducting0.51103115
121MP0010769_abnormal_survival0.49789299
122MP0005448_abnormal_energy_balance0.49440487
123MP0004484_altered_response_of0.49340813

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.13842183
2Epileptic encephalopathy (HP:0200134)5.92347508
3Febrile seizures (HP:0002373)5.88887184
4Hyperventilation (HP:0002883)5.83224669
5Atonic seizures (HP:0010819)5.82515414
6Focal seizures (HP:0007359)5.71016986
7Absence seizures (HP:0002121)4.45370862
8Myokymia (HP:0002411)4.42174001
9Dialeptic seizures (HP:0011146)4.31576095
10Visual hallucinations (HP:0002367)4.19486094
11Broad-based gait (HP:0002136)4.03089432
12Generalized tonic-clonic seizures (HP:0002069)3.92904800
13Molar tooth sign on MRI (HP:0002419)3.83100274
14Abnormality of midbrain morphology (HP:0002418)3.83100274
15Pancreatic cysts (HP:0001737)3.82373829
16Progressive cerebellar ataxia (HP:0002073)3.70152157
17Nephronophthisis (HP:0000090)3.61309563
18True hermaphroditism (HP:0010459)3.57381695
19Protruding tongue (HP:0010808)3.47233820
20Pancreatic fibrosis (HP:0100732)3.42020732
21Gaze-evoked nystagmus (HP:0000640)3.38255094
22Poor eye contact (HP:0000817)3.26984969
23Type II lissencephaly (HP:0007260)3.25826436
24Polyphagia (HP:0002591)3.18438722
25Drooling (HP:0002307)3.17407439
26Excessive salivation (HP:0003781)3.17407439
27Abnormal hair whorl (HP:0010721)3.13792176
28Congenital stationary night blindness (HP:0007642)3.11812803
29Absent speech (HP:0001344)3.09786237
30Epileptiform EEG discharges (HP:0011182)3.03532384
31Abnormality of the renal cortex (HP:0011035)3.02533041
32Abnormality of the renal medulla (HP:0100957)3.00250659
33Gait imbalance (HP:0002141)2.94996827
34Abnormal social behavior (HP:0012433)2.92976415
35Impaired social interactions (HP:0000735)2.92976415
36Amblyopia (HP:0000646)2.92639346
37Inability to walk (HP:0002540)2.91048168
38Truncal ataxia (HP:0002078)2.89198639
39Abnormal eating behavior (HP:0100738)2.84654439
40Blue irides (HP:0000635)2.80037089
41Progressive inability to walk (HP:0002505)2.80002886
42Medial flaring of the eyebrow (HP:0010747)2.79212819
43EEG with generalized epileptiform discharges (HP:0011198)2.78138512
44Congenital primary aphakia (HP:0007707)2.72283602
45Renal cortical cysts (HP:0000803)2.72169117
46Abnormal drinking behavior (HP:0030082)2.68292921
47Polydipsia (HP:0001959)2.68292921
48Impaired vibration sensation in the lower limbs (HP:0002166)2.63647400
49Hypsarrhythmia (HP:0002521)2.60995467
50Nephrogenic diabetes insipidus (HP:0009806)2.59608976
51Dysdiadochokinesis (HP:0002075)2.57466748
52Intestinal atresia (HP:0011100)2.57001687
53Lissencephaly (HP:0001339)2.55505506
54Chronic hepatic failure (HP:0100626)2.53615104
55Attenuation of retinal blood vessels (HP:0007843)2.49975698
56Fair hair (HP:0002286)2.46330828
57Status epilepticus (HP:0002133)2.45379939
58Generalized hypopigmentation of hair (HP:0011358)2.38335825
59Abnormal rod and cone electroretinograms (HP:0008323)2.37477660
60Pheochromocytoma (HP:0002666)2.36791023
61Poor suck (HP:0002033)2.34492847
62Fetal akinesia sequence (HP:0001989)2.33788578
63Absent/shortened dynein arms (HP:0200106)2.31532203
64Dynein arm defect of respiratory motile cilia (HP:0012255)2.31532203
65Cerebellar dysplasia (HP:0007033)2.31077675
66Tubular atrophy (HP:0000092)2.28109748
67Abnormality of salivation (HP:0100755)2.26171338
68Failure to thrive in infancy (HP:0001531)2.25122790
69Abolished electroretinogram (ERG) (HP:0000550)2.24752718
70Aplasia/Hypoplasia of the tibia (HP:0005772)2.23659400
71Neuroendocrine neoplasm (HP:0100634)2.23508569
72Dysmetria (HP:0001310)2.23337432
73Pendular nystagmus (HP:0012043)2.21882558
74Anxiety (HP:0000739)2.19825716
75Limb dystonia (HP:0002451)2.18318107
76Cystic liver disease (HP:0006706)2.18094701
77Specific learning disability (HP:0001328)2.17272718
78Impaired smooth pursuit (HP:0007772)2.17079963
79Esotropia (HP:0000565)2.16806435
80Depression (HP:0000716)2.13290789
81Genital tract atresia (HP:0001827)2.12405687
82Increased corneal curvature (HP:0100692)2.11855667
83Keratoconus (HP:0000563)2.11855667
84Vaginal atresia (HP:0000148)2.09665822
85Pachygyria (HP:0001302)2.09560586
86Abnormality of the labia minora (HP:0012880)2.09189030
87Diplopia (HP:0000651)2.05984936
88Abnormality of binocular vision (HP:0011514)2.05984936
89Poor coordination (HP:0002370)2.05115967
90Hemiparesis (HP:0001269)2.04942575
91Acute necrotizing encephalopathy (HP:0006965)2.04612759
92Congenital sensorineural hearing impairment (HP:0008527)2.03261799
93Urinary bladder sphincter dysfunction (HP:0002839)2.02910739
94Hemiplegia (HP:0002301)2.01027628
95Postaxial hand polydactyly (HP:0001162)2.00163687
96Generalized myoclonic seizures (HP:0002123)1.99981095
97Exotropia (HP:0000577)1.99267332
98Hyperthyroidism (HP:0000836)1.98104536
99Oligodactyly (hands) (HP:0001180)1.97326292
100Scanning speech (HP:0002168)1.96643176
101Large for gestational age (HP:0001520)1.95840642
102Congenital hepatic fibrosis (HP:0002612)1.94878151
103Polyuria (HP:0000103)1.94082624
104Sleep apnea (HP:0010535)1.93575417
105Abnormal mitochondria in muscle tissue (HP:0008316)1.92727554
106Sclerocornea (HP:0000647)1.90013432
107Action tremor (HP:0002345)1.88622432
108Stomach cancer (HP:0012126)1.88313451
109Stereotypic behavior (HP:0000733)1.88291876
110Hypothermia (HP:0002045)1.87655048
111Abnormality of macular pigmentation (HP:0008002)1.87327488
112Progressive macrocephaly (HP:0004481)1.84938079
113Narrow nasal bridge (HP:0000446)1.84446645
114Impaired vibratory sensation (HP:0002495)1.84138153
115Severe muscular hypotonia (HP:0006829)1.83881018
116Oligomenorrhea (HP:0000876)1.83603842
117Aplasia/Hypoplasia of the lens (HP:0008063)1.82855755
118Thickened helices (HP:0000391)1.82585505
119Narrow forehead (HP:0000341)1.82519349
120Gastroesophageal reflux (HP:0002020)1.82462032
121Short tibia (HP:0005736)1.82051904
122Gait ataxia (HP:0002066)1.81746200
123Optic nerve hypoplasia (HP:0000609)1.81718256
124Bradykinesia (HP:0002067)1.81659863
125Cortical visual impairment (HP:0100704)1.81134316
126Genetic anticipation (HP:0003743)1.81086599
127Abnormality of ocular smooth pursuit (HP:0000617)1.80470722
128Bony spicule pigmentary retinopathy (HP:0007737)1.78798597
129Mitochondrial inheritance (HP:0001427)1.78629856
130Agitation (HP:0000713)1.78463223
131Aplasia/Hypoplasia of the tongue (HP:0010295)1.78404834
132Decreased central vision (HP:0007663)1.77774651
133Methylmalonic acidemia (HP:0002912)1.76108229
134Widely spaced teeth (HP:0000687)1.76056666
135Postaxial foot polydactyly (HP:0001830)1.75899153
136Abnormal urine output (HP:0012590)1.75757928
137Colon cancer (HP:0003003)1.75453911
138Ankle clonus (HP:0011448)1.75093143
139Bile duct proliferation (HP:0001408)1.74470654
140Abnormal biliary tract physiology (HP:0012439)1.74470654
141Furrowed tongue (HP:0000221)1.74278675
142Increased CSF lactate (HP:0002490)1.72464339
143Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.72361696
144Spastic tetraplegia (HP:0002510)1.72113459
145Anencephaly (HP:0002323)1.71281109
146Spastic gait (HP:0002064)1.70797842
147Occipital encephalocele (HP:0002085)1.70566723
148Decreased circulating renin level (HP:0003351)1.69877564
149Male pseudohermaphroditism (HP:0000037)1.69089205
150Thyroid-stimulating hormone excess (HP:0002925)1.68052789
151Hyperalaninemia (HP:0003348)1.66794549
152Retinal dysplasia (HP:0007973)1.66142888
153Abnormal ciliary motility (HP:0012262)1.63416062
154Dysmetric saccades (HP:0000641)1.62609528
155Supranuclear gaze palsy (HP:0000605)1.62487469
156Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.61122863
157Generalized hypotonia (HP:0001290)1.59874227
158Hip dysplasia (HP:0001385)1.59675473
159Termporal pattern (HP:0011008)1.59243449

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.81314946
2FRK4.56491852
3NTRK34.49440160
4EPHA43.83615926
5MAP2K73.42285011
6MAP3K43.08403889
7MAP4K22.69930903
8MAP3K122.56531109
9PINK12.35515717
10MARK12.11582569
11DAPK22.10407609
12MAP3K92.08445465
13PRPF4B2.03563963
14PLK21.99930923
15CAMKK21.96534669
16AKT31.92408464
17TNIK1.91158530
18DAPK11.83062074
19MAP2K41.82039413
20NTRK21.80958043
21MINK11.80324824
22RIPK41.78358095
23CSNK1G11.74268992
24SIK31.72483170
25TRIM281.65531842
26CDK191.63453337
27GRK11.62656848
28CSNK1G31.61117646
29MAPK131.46051970
30GRK51.44095564
31DYRK21.43393561
32CCNB11.43270684
33INSRR1.42160678
34STK391.38116049
35CSNK1A1L1.36779849
36WNK41.36435423
37NUAK11.33518906
38SIK21.33012296
39PNCK1.28681003
40PRKCG1.27651793
41PAK61.25795995
42CDK51.21316714
43TAOK31.20778509
44MKNK21.19586407
45CAMK2A1.18009219
46STK38L1.16349993
47KSR11.14247202
48MAPK151.13862565
49WNK31.11499438
50BMPR21.11041239
51SGK21.10470418
52OXSR11.09557176
53CAMKK11.07588981
54ACVR1B1.05474908
55CAMK2B1.01536775
56SGK2230.99151904
57SGK4940.99151904
58TSSK60.96863606
59FGFR20.96747343
60FES0.94890509
61ZAK0.93840823
62PRKCE0.93523555
63UHMK10.91749590
64ADRBK20.87292574
65CAMK10.86398337
66PTK2B0.86330249
67CAMK1G0.85274159
68NME10.85234815
69MUSK0.84330125
70BCR0.83170139
71ARAF0.81527350
72ERBB40.81429526
73BRAF0.76756390
74DYRK1A0.74300263
75NTRK10.72161946
76GRK70.72126338
77FGR0.70540245
78ADRBK10.70157462
79CDK30.69452273
80SGK10.66541945
81CDK180.59054168
82DYRK30.58764003
83SGK30.58673536
84VRK10.58250474
85MAP3K130.57829399
86CSNK1A10.56253380
87CAMK2D0.56070126
88PLK40.55984457
89PKN10.55584592
90TNK20.54909200
91BMPR1B0.52792839
92EPHA30.51904715
93STK380.50475332
94MAPKAPK50.50394530
95CAMK2G0.49926074
96CDK150.49664040
97STK110.49338455
98CSNK1D0.49125415
99PRKD30.48052200
100TLK10.47454997
101FER0.46731639
102NEK60.46347273
103CDK140.45790111
104YES10.45041055
105PHKG10.44324492
106PHKG20.44324492
107PDK40.42874385
108PDK30.42874385
109PRKCI0.42860858
110CSNK1G20.42723752
111CDC42BPA0.42327123
112BRSK20.41675717
113CDK11A0.41424129
114PRKACA0.41299509
115PLK30.40466324
116KSR20.38134851
117ROCK10.37501347
118RPS6KA30.37125951
119TIE10.36920085
120PAK30.36909268
121ERBB30.36605092
122CAMK1D0.35828433
123RPS6KA50.35639839
124PRKCZ0.35404160
125MAPK70.35290185
126PRKG10.34966438
127PRKCA0.34870914
128CAMK40.34846047
129PRKCB0.34536582
130MKNK10.33434970
131MAP2K60.33310217
132PDPK10.32881713
133MAPKAPK30.32280061
134TYRO30.31797796
135MAP3K60.31568274
136WNK10.31010324
137MARK20.30644861
138MAPK120.30566662
139BCKDK0.29492869
140WEE10.28905508
141NLK0.28360678

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.68399803
2Synaptic vesicle cycle_Homo sapiens_hsa047213.54105512
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.08730219
4GABAergic synapse_Homo sapiens_hsa047272.85858747
5Collecting duct acid secretion_Homo sapiens_hsa049662.85356916
6Morphine addiction_Homo sapiens_hsa050322.74103233
7Circadian entrainment_Homo sapiens_hsa047132.59671494
8Glutamatergic synapse_Homo sapiens_hsa047242.58361103
9Amphetamine addiction_Homo sapiens_hsa050312.52065532
10Long-term potentiation_Homo sapiens_hsa047202.49496399
11Taste transduction_Homo sapiens_hsa047422.38742793
12Olfactory transduction_Homo sapiens_hsa047402.36704078
13Insulin secretion_Homo sapiens_hsa049112.19580340
14Dopaminergic synapse_Homo sapiens_hsa047282.12459195
15Serotonergic synapse_Homo sapiens_hsa047262.05993668
16Salivary secretion_Homo sapiens_hsa049702.00019526
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.90506781
18Protein export_Homo sapiens_hsa030601.88965051
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.84909061
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.79897066
21Caffeine metabolism_Homo sapiens_hsa002321.77817225
22Vibrio cholerae infection_Homo sapiens_hsa051101.75696311
23Cocaine addiction_Homo sapiens_hsa050301.71510296
24Calcium signaling pathway_Homo sapiens_hsa040201.70833166
25Cholinergic synapse_Homo sapiens_hsa047251.70154426
26Linoleic acid metabolism_Homo sapiens_hsa005911.69241860
27Long-term depression_Homo sapiens_hsa047301.69103773
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.68960105
29Renin secretion_Homo sapiens_hsa049241.65217778
30Oxidative phosphorylation_Homo sapiens_hsa001901.60106014
31Nitrogen metabolism_Homo sapiens_hsa009101.59985205
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54898985
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.54491925
34Oxytocin signaling pathway_Homo sapiens_hsa049211.51912389
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.49180928
36Gastric acid secretion_Homo sapiens_hsa049711.47078998
37Selenocompound metabolism_Homo sapiens_hsa004501.40481251
38Tryptophan metabolism_Homo sapiens_hsa003801.29569379
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.29167031
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.29120495
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.27436477
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18031206
43Phototransduction_Homo sapiens_hsa047441.16590332
44Propanoate metabolism_Homo sapiens_hsa006401.15982966
45Type I diabetes mellitus_Homo sapiens_hsa049401.15887203
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15398865
47Cardiac muscle contraction_Homo sapiens_hsa042601.13182696
48cAMP signaling pathway_Homo sapiens_hsa040241.12172651
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.11544594
50Basal transcription factors_Homo sapiens_hsa030221.10485977
51Alzheimers disease_Homo sapiens_hsa050101.09263083
52Gap junction_Homo sapiens_hsa045401.08191119
53GnRH signaling pathway_Homo sapiens_hsa049121.07608983
54Peroxisome_Homo sapiens_hsa041461.07332648
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02749370
56Axon guidance_Homo sapiens_hsa043601.01517680
57Type II diabetes mellitus_Homo sapiens_hsa049301.01099483
58beta-Alanine metabolism_Homo sapiens_hsa004101.00616300
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96910821
60Fanconi anemia pathway_Homo sapiens_hsa034600.95680989
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92444264
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90473801
63Parkinsons disease_Homo sapiens_hsa050120.89484736
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.88706822
65RNA polymerase_Homo sapiens_hsa030200.88489817
66Rheumatoid arthritis_Homo sapiens_hsa053230.87760900
67ErbB signaling pathway_Homo sapiens_hsa040120.83602193
68Estrogen signaling pathway_Homo sapiens_hsa049150.82712776
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.82647169
70ABC transporters_Homo sapiens_hsa020100.82430002
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82287809
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81672252
73Steroid biosynthesis_Homo sapiens_hsa001000.77470573
74Pancreatic secretion_Homo sapiens_hsa049720.76540421
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76057461
76Melanogenesis_Homo sapiens_hsa049160.75237369
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74232559
78Chemical carcinogenesis_Homo sapiens_hsa052040.72590862
79Homologous recombination_Homo sapiens_hsa034400.71790459
80RNA degradation_Homo sapiens_hsa030180.71584766
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71061087
82Fatty acid metabolism_Homo sapiens_hsa012120.67126520
83MAPK signaling pathway_Homo sapiens_hsa040100.66911635
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66788812
85Dilated cardiomyopathy_Homo sapiens_hsa054140.66228151
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.66123648
87Glioma_Homo sapiens_hsa052140.64561674
88Histidine metabolism_Homo sapiens_hsa003400.64457271
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64129548
90Huntingtons disease_Homo sapiens_hsa050160.64098642
91Circadian rhythm_Homo sapiens_hsa047100.63881419
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63308822
93Retinol metabolism_Homo sapiens_hsa008300.59461558
94Butanoate metabolism_Homo sapiens_hsa006500.57291883
95Glycerolipid metabolism_Homo sapiens_hsa005610.55935880
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54861578
97Glucagon signaling pathway_Homo sapiens_hsa049220.54094383
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53415490
99Phagosome_Homo sapiens_hsa041450.53186356
100Fat digestion and absorption_Homo sapiens_hsa049750.52421625
101Thyroid hormone synthesis_Homo sapiens_hsa049180.51172846
102Ras signaling pathway_Homo sapiens_hsa040140.50848239
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49332881
104Choline metabolism in cancer_Homo sapiens_hsa052310.47824641
105Alcoholism_Homo sapiens_hsa050340.47726265
106Fatty acid elongation_Homo sapiens_hsa000620.47480807
107Fatty acid biosynthesis_Homo sapiens_hsa000610.47064640
108Ovarian steroidogenesis_Homo sapiens_hsa049130.46913580
109Oocyte meiosis_Homo sapiens_hsa041140.45801776
110Mineral absorption_Homo sapiens_hsa049780.45575463
111Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44424951
112Fatty acid degradation_Homo sapiens_hsa000710.42263410
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41734132
114Metabolic pathways_Homo sapiens_hsa011000.41404299
115African trypanosomiasis_Homo sapiens_hsa051430.41244835
116Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40135020
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39813476
118Purine metabolism_Homo sapiens_hsa002300.39794091
119Sulfur metabolism_Homo sapiens_hsa009200.39542613
120Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38170964
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.37922307
122Maturity onset diabetes of the young_Homo sapiens_hsa049500.37455665
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37425231
124Inositol phosphate metabolism_Homo sapiens_hsa005620.37138392
125Rap1 signaling pathway_Homo sapiens_hsa040150.36889125
126Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35676639
127Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34201326
128Dorso-ventral axis formation_Homo sapiens_hsa043200.31802597
129Wnt signaling pathway_Homo sapiens_hsa043100.31571981
130Arachidonic acid metabolism_Homo sapiens_hsa005900.30964609
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30197423
132SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30119239
133Regulation of autophagy_Homo sapiens_hsa041400.29728576
134Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29009898
135Hedgehog signaling pathway_Homo sapiens_hsa043400.28961133
136Prion diseases_Homo sapiens_hsa050200.28398004
137Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25410411
138Melanoma_Homo sapiens_hsa052180.24046575
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.24003814
140Ether lipid metabolism_Homo sapiens_hsa005650.23759086
141Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.17559939
142Carbohydrate digestion and absorption_Homo sapiens_hsa049730.17109669
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.15268371
144Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.14409464

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »