SNU13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. It binds to the 5' stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.90296425
2energy coupled proton transport, down electrochemical gradient (GO:0015985)6.07373151
3ATP synthesis coupled proton transport (GO:0015986)6.07373151
4establishment of protein localization to mitochondrial membrane (GO:0090151)5.44074054
5chaperone-mediated protein transport (GO:0072321)5.37991248
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.30760840
7respiratory electron transport chain (GO:0022904)5.13697431
8proteasome assembly (GO:0043248)5.12934409
9electron transport chain (GO:0022900)5.02675785
10viral transcription (GO:0019083)4.96323308
11ribosomal small subunit biogenesis (GO:0042274)4.95889687
12ribosomal small subunit assembly (GO:0000028)4.89380528
13translational termination (GO:0006415)4.80648482
14regulation of mitochondrial translation (GO:0070129)4.80216432
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.66102147
16cotranslational protein targeting to membrane (GO:0006613)4.60349227
17protein complex biogenesis (GO:0070271)4.59116379
18protein targeting to ER (GO:0045047)4.55863273
19ribosomal large subunit biogenesis (GO:0042273)4.45587379
20mitochondrial respiratory chain complex assembly (GO:0033108)4.40759261
21establishment of protein localization to endoplasmic reticulum (GO:0072599)4.39146609
22protein localization to endoplasmic reticulum (GO:0070972)4.35332998
23translational elongation (GO:0006414)4.32513542
24protein targeting to mitochondrion (GO:0006626)4.31426072
25maturation of SSU-rRNA (GO:0030490)4.28877572
26mitochondrial respiratory chain complex I assembly (GO:0032981)4.24274119
27NADH dehydrogenase complex assembly (GO:0010257)4.24274119
28mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.24274119
29negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.20039635
30termination of RNA polymerase III transcription (GO:0006386)4.18170774
31transcription elongation from RNA polymerase III promoter (GO:0006385)4.18170774
32establishment of protein localization to mitochondrion (GO:0072655)4.05020461
33translation (GO:0006412)4.03356275
34translational initiation (GO:0006413)4.01090090
35rRNA modification (GO:0000154)3.97681834
36establishment of integrated proviral latency (GO:0075713)3.97265922
37respiratory chain complex IV assembly (GO:0008535)3.96471783
38protein localization to mitochondrion (GO:0070585)3.95260686
39positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.94508339
40regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.90477603
41viral life cycle (GO:0019058)3.87249013
42negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.87089165
43negative regulation of ligase activity (GO:0051352)3.87089165
44pseudouridine synthesis (GO:0001522)3.86110167
45nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.84806227
46cellular protein complex disassembly (GO:0043624)3.80830002
47cellular component biogenesis (GO:0044085)3.80050830
48anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.76964595
49regulation of cellular amino acid metabolic process (GO:0006521)3.73373760
50ribonucleoprotein complex biogenesis (GO:0022613)3.71066576
51cytochrome complex assembly (GO:0017004)3.69404585
52oxidative phosphorylation (GO:0006119)3.66496107
53deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.62066923
54spliceosomal snRNP assembly (GO:0000387)3.58928926
55DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.56358347
56protein neddylation (GO:0045116)3.55927819
57inner mitochondrial membrane organization (GO:0007007)3.55406137
58ATP biosynthetic process (GO:0006754)3.55399995
59rRNA processing (GO:0006364)3.54226504
60signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.50503063
61signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.50503063
62signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.50503063
63cullin deneddylation (GO:0010388)3.50137108
64signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.48230654
65intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.48230654
66purine nucleoside triphosphate biosynthetic process (GO:0009145)3.48200229
67positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.47995009
68purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.46443638
69formation of translation preinitiation complex (GO:0001731)3.41464203
70signal transduction involved in DNA damage checkpoint (GO:0072422)3.41438896
71signal transduction involved in DNA integrity checkpoint (GO:0072401)3.41438896
72rRNA metabolic process (GO:0016072)3.38837709
73signal transduction involved in cell cycle checkpoint (GO:0072395)3.35271342
74establishment of viral latency (GO:0019043)3.34741431
75positive regulation of ligase activity (GO:0051351)3.31395555
76protein complex disassembly (GO:0043241)3.28219136
77hydrogen ion transmembrane transport (GO:1902600)3.27695998
78nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.27531512
79ribonucleoside triphosphate biosynthetic process (GO:0009201)3.26758270
80mitochondrial transport (GO:0006839)3.25240731
81protein deneddylation (GO:0000338)3.24093525
82exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.23767331
83RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.22662726
84tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.22662726
85macromolecular complex disassembly (GO:0032984)3.19009915
86maturation of 5.8S rRNA (GO:0000460)3.18646548
87GTP biosynthetic process (GO:0006183)3.18081842
88DNA strand elongation involved in DNA replication (GO:0006271)3.17203916
89intracellular protein transmembrane import (GO:0044743)3.16732633
90telomere maintenance via semi-conservative replication (GO:0032201)3.14824161
91regulation of ubiquitin-protein transferase activity (GO:0051438)3.14142370
92guanosine-containing compound biosynthetic process (GO:1901070)3.13387259
93protein-cofactor linkage (GO:0018065)3.12375238
94aerobic respiration (GO:0009060)3.12303667
95protein targeting to membrane (GO:0006612)3.12111405
96peptidyl-histidine modification (GO:0018202)3.10831655
97DNA damage response, detection of DNA damage (GO:0042769)3.10252994
98purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.10155547
99purine nucleoside monophosphate biosynthetic process (GO:0009127)3.10155547
1007-methylguanosine mRNA capping (GO:0006370)3.08580549

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.30418336
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.45553011
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.29610019
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.20100677
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.11948561
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.83017270
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.78999816
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.77541503
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.59722294
10E2F7_22180533_ChIP-Seq_HELA_Human3.54398738
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.46956659
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.37770274
13MYC_18358816_ChIP-ChIP_MESCs_Mouse3.15709542
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.99510828
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.99241778
16THAP11_20581084_ChIP-Seq_MESCs_Mouse2.95578387
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.78686769
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.76485662
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.61887928
20XRN2_22483619_ChIP-Seq_HELA_Human2.61248125
21VDR_23849224_ChIP-Seq_CD4+_Human2.48585680
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.48419146
23DCP1A_22483619_ChIP-Seq_HELA_Human2.45197942
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.43995139
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.43501091
26FOXP3_21729870_ChIP-Seq_TREG_Human2.41005847
27TTF2_22483619_ChIP-Seq_HELA_Human2.34347527
28SRF_21415370_ChIP-Seq_HL-1_Mouse2.32407245
29E2F1_18555785_ChIP-Seq_MESCs_Mouse2.31612129
30YY1_21170310_ChIP-Seq_MESCs_Mouse2.28351670
31GABP_19822575_ChIP-Seq_HepG2_Human2.21683258
32ELK1_19687146_ChIP-ChIP_HELA_Human2.18840385
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.14560378
34NELFA_20434984_ChIP-Seq_ESCs_Mouse2.11394425
35ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.03803183
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.98356486
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.90272175
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82694604
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.74466604
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.72582802
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71838777
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.69515502
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60987824
44MYC_18940864_ChIP-ChIP_HL60_Human1.54862189
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.53247871
46CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.50105322
47POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.49792212
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.46759538
49CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.45926073
50KDM5A_27292631_Chip-Seq_BREAST_Human1.45401564
51ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.44925278
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40456640
53PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38009624
54CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.35769554
55BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.33128468
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28989874
57NANOG_18555785_ChIP-Seq_MESCs_Mouse1.27297577
58NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26281352
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.25925634
60SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.22499266
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20828161
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18265641
63FOXM1_23109430_ChIP-Seq_U2OS_Human1.16576059
64ELK1_22589737_ChIP-Seq_MCF10A_Human1.15003101
65DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14057111
66ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11195554
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08077961
68CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07416624
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07228385
70E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05200170
71HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00862936
72KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00341378
73SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.97915319
74CIITA_25753668_ChIP-Seq_RAJI_Human0.97593843
75ZNF263_19887448_ChIP-Seq_K562_Human0.97165333
76FOXP1_21924763_ChIP-Seq_HESCs_Human0.96101401
77CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96063607
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94177338
79AR_21909140_ChIP-Seq_LNCAP_Human0.90429625
80SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86598490
81CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86462354
82SOX2_18555785_ChIP-Seq_MESCs_Mouse0.86448316
83SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.84455374
84POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.83329290
85CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.80326014
86SOX2_16153702_ChIP-ChIP_HESCs_Human0.80175188
87FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.78453578
88CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.77901348
89SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77226851
90NOTCH1_21737748_ChIP-Seq_TLL_Human0.76333881
91SOX17_20123909_ChIP-Seq_XEN_Mouse0.76259426
92PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.76159164
93TBX5_21415370_ChIP-Seq_HL-1_Mouse0.75963294
94STAT3_1855785_ChIP-Seq_MESCs_Mouse0.74956082
95NANOG_16153702_ChIP-ChIP_HESCs_Human0.74378107
96KLF4_18555785_ChIP-Seq_MESCs_Mouse0.73982783
97CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.73717543
98OCT4_18692474_ChIP-Seq_MEFs_Mouse0.72481891
99TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.71019932
100TFEB_21752829_ChIP-Seq_HELA_Human0.70124318

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair3.76823331
2MP0009379_abnormal_foot_pigmentation3.65918374
3MP0003693_abnormal_embryo_hatching3.56356149
4MP0004957_abnormal_blastocyst_morpholog2.99641479
5MP0010094_abnormal_chromosome_stability2.94156656
6MP0006036_abnormal_mitochondrial_physio2.87047550
7MP0003186_abnormal_redox_activity2.71157340
8MP0003111_abnormal_nucleus_morphology2.66425446
9MP0006035_abnormal_mitochondrial_morpho2.60101064
10MP0003806_abnormal_nucleotide_metabolis2.55345458
11MP0001529_abnormal_vocalization2.30306884
12MP0003077_abnormal_cell_cycle2.28168329
13MP0003786_premature_aging2.25992596
14MP0006292_abnormal_olfactory_placode2.23821279
15MP0003718_maternal_effect2.21180950
16MP0008877_abnormal_DNA_methylation2.20358605
17MP0008932_abnormal_embryonic_tissue2.11926537
18MP0003880_abnormal_central_pattern2.03876165
19MP0002938_white_spotting1.98854814
20MP0008007_abnormal_cellular_replicative1.84678662
21MP0002837_dystrophic_cardiac_calcinosis1.84476450
22MP0004147_increased_porphyrin_level1.83096591
23MP0003123_paternal_imprinting1.74066239
24MP0000372_irregular_coat_pigmentation1.70094358
25MP0009046_muscle_twitch1.69192001
26MP0001905_abnormal_dopamine_level1.65533919
27MP0002736_abnormal_nociception_after1.65228789
28MP0002163_abnormal_gland_morphology1.58816185
29MP0001188_hyperpigmentation1.53125358
30MP0001968_abnormal_touch/_nociception1.46678122
31MP0000358_abnormal_cell_content/1.40243019
32MP0008995_early_reproductive_senescence1.40168308
33MP0006072_abnormal_retinal_apoptosis1.37719451
34MP0005084_abnormal_gallbladder_morpholo1.36766257
35MP0005645_abnormal_hypothalamus_physiol1.36031913
36MP0009745_abnormal_behavioral_response1.34213876
37MP0008789_abnormal_olfactory_epithelium1.33164212
38MP0002272_abnormal_nervous_system1.32256322
39MP0010030_abnormal_orbit_morphology1.32135366
40MP0009697_abnormal_copulation1.31366234
41MP0005379_endocrine/exocrine_gland_phen1.30515197
42MP0003122_maternal_imprinting1.29325263
43MP0003121_genomic_imprinting1.26595636
44MP0002102_abnormal_ear_morphology1.26465039
45MP0002210_abnormal_sex_determination1.25103812
46MP0002160_abnormal_reproductive_system1.22003745
47MP0005423_abnormal_somatic_nervous1.21517121
48MP0004142_abnormal_muscle_tone1.18348526
49MP0001293_anophthalmia1.17937859
50MP0005646_abnormal_pituitary_gland1.16364671
51MP0001984_abnormal_olfaction1.12738004
52MP0006276_abnormal_autonomic_nervous1.10055575
53MP0001929_abnormal_gametogenesis1.03800550
54MP0003315_abnormal_perineum_morphology1.03739177
55MP0000350_abnormal_cell_proliferation1.02896408
56MP0005499_abnormal_olfactory_system1.02470530
57MP0005394_taste/olfaction_phenotype1.02470530
58MP0002064_seizures1.00190164
59MP0004859_abnormal_synaptic_plasticity0.97200145
60MP0003011_delayed_dark_adaptation0.94574051
61MP0003787_abnormal_imprinting0.94018046
62MP0001145_abnormal_male_reproductive0.94012523
63MP0000631_abnormal_neuroendocrine_gland0.93287824
64MP0001730_embryonic_growth_arrest0.93170316
65MP0002734_abnormal_mechanical_nocicepti0.92397613
66MP0000313_abnormal_cell_death0.89131950
67MP0002638_abnormal_pupillary_reflex0.89047936
68MP0000653_abnormal_sex_gland0.88857954
69MP0008872_abnormal_physiological_respon0.88510076
70MP0001764_abnormal_homeostasis0.88048885
71MP0003567_abnormal_fetal_cardiomyocyte0.87345657
72MP0005332_abnormal_amino_acid0.86340857
73MP0005551_abnormal_eye_electrophysiolog0.86102461
74MP0005408_hypopigmentation0.86011825
75MP0003635_abnormal_synaptic_transmissio0.85747687
76MP0002822_catalepsy0.83922695
77MP0001346_abnormal_lacrimal_gland0.82570538
78MP0001697_abnormal_embryo_size0.81936038
79MP0005075_abnormal_melanosome_morpholog0.81317613
80MP0002572_abnormal_emotion/affect_behav0.81182047
81MP0005636_abnormal_mineral_homeostasis0.80851564
82MP0002277_abnormal_respiratory_mucosa0.80133788
83MP0003698_abnormal_male_reproductive0.77864066
84MP0005389_reproductive_system_phenotype0.76729329
85MP0004270_analgesia0.75968657
86MP0002095_abnormal_skin_pigmentation0.73154875
87MP0001485_abnormal_pinna_reflex0.72353588
88MP0001986_abnormal_taste_sensitivity0.72092445
89MP0000049_abnormal_middle_ear0.71752858
90MP0002557_abnormal_social/conspecific_i0.71738611
91MP0008875_abnormal_xenobiotic_pharmacok0.71719276
92MP0003136_yellow_coat_color0.70698096
93MP0004133_heterotaxia0.70565077
94MP0002080_prenatal_lethality0.69306457
95MP0002735_abnormal_chemical_nociception0.67092209
96MP0001970_abnormal_pain_threshold0.64340715
97MP0003938_abnormal_ear_development0.63932156
98MP0004742_abnormal_vestibular_system0.62532731
99MP0002653_abnormal_ependyma_morphology0.61598307
100MP0002161_abnormal_fertility/fecundity0.61596393

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.07844194
2Abnormal mitochondria in muscle tissue (HP:0008316)5.70994484
3Mitochondrial inheritance (HP:0001427)5.37547359
4Acute encephalopathy (HP:0006846)5.25318384
5Progressive macrocephaly (HP:0004481)5.07799671
6Increased CSF lactate (HP:0002490)4.99651586
7Increased hepatocellular lipid droplets (HP:0006565)4.74969909
8Hepatocellular necrosis (HP:0001404)4.73216576
9Hepatic necrosis (HP:0002605)4.35094363
10Lipid accumulation in hepatocytes (HP:0006561)4.33336183
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.25576509
12Decreased activity of mitochondrial respiratory chain (HP:0008972)4.25576509
13Renal Fanconi syndrome (HP:0001994)4.21014144
14Cerebral edema (HP:0002181)3.88291654
15Abnormal number of erythroid precursors (HP:0012131)3.81895934
16Abnormality of cells of the erythroid lineage (HP:0012130)3.79426046
17Increased intramyocellular lipid droplets (HP:0012240)3.76523673
18Reticulocytopenia (HP:0001896)3.61483329
19Increased serum lactate (HP:0002151)3.52733437
20Lactic acidosis (HP:0003128)3.44919882
21Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.44445276
22Macrocytic anemia (HP:0001972)3.36396920
23Exercise intolerance (HP:0003546)3.34762045
24Increased muscle lipid content (HP:0009058)3.13447489
25Respiratory failure (HP:0002878)3.12924823
263-Methylglutaconic aciduria (HP:0003535)3.10492885
27Increased serum pyruvate (HP:0003542)3.03688032
28Cerebral hypomyelination (HP:0006808)3.01437304
29Abnormality of glycolysis (HP:0004366)2.99413868
30Leukodystrophy (HP:0002415)2.97908919
31Type I transferrin isoform profile (HP:0003642)2.89608498
32Exertional dyspnea (HP:0002875)2.86984805
33Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.81336090
34Aplastic anemia (HP:0001915)2.81036563
35Microvesicular hepatic steatosis (HP:0001414)2.79281122
36Myokymia (HP:0002411)2.71092329
37Optic disc pallor (HP:0000543)2.68753568
38Respiratory difficulties (HP:0002880)2.67660793
39Aplasia/Hypoplasia of the sacrum (HP:0008517)2.51112606
40Lethargy (HP:0001254)2.46200454
41Methylmalonic aciduria (HP:0012120)2.43594611
42Abnormality of renal resorption (HP:0011038)2.43296266
43Degeneration of anterior horn cells (HP:0002398)2.42414765
44Abnormality of the anterior horn cell (HP:0006802)2.42414765
45Abnormality of the labia minora (HP:0012880)2.38456385
46Abnormal protein glycosylation (HP:0012346)2.34166529
47Abnormal glycosylation (HP:0012345)2.34166529
48Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.34166529
49Abnormal protein N-linked glycosylation (HP:0012347)2.34166529
50Methylmalonic acidemia (HP:0002912)2.30306116
51Emotional lability (HP:0000712)2.28479168
52CNS hypomyelination (HP:0003429)2.26474416
53Pallor (HP:0000980)2.21847255
54Oral leukoplakia (HP:0002745)2.16526431
55Pancytopenia (HP:0001876)2.15153390
56CNS demyelination (HP:0007305)2.11366494
57X-linked dominant inheritance (HP:0001423)2.09027237
58Progressive muscle weakness (HP:0003323)2.04475543
59Poor suck (HP:0002033)2.04423623
60Abnormality of urine glucose concentration (HP:0011016)2.00024729
61Glycosuria (HP:0003076)2.00024729
62Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.99775447
63Abnormality of alanine metabolism (HP:0010916)1.99775447
64Hyperalaninemia (HP:0003348)1.99775447
65Progressive microcephaly (HP:0000253)1.99155880
66Hyperphosphaturia (HP:0003109)1.98528839
67Reduced antithrombin III activity (HP:0001976)1.97452068
68Testicular atrophy (HP:0000029)1.94918014
69Colon cancer (HP:0003003)1.88065167
70Abnormality of methionine metabolism (HP:0010901)1.87409320
71Generalized aminoaciduria (HP:0002909)1.86669308
72Meckel diverticulum (HP:0002245)1.86181348
73Abnormality of aromatic amino acid family metabolism (HP:0004338)1.85211518
74Aplasia/hypoplasia of the uterus (HP:0008684)1.84178635
75Absent thumb (HP:0009777)1.84076456
76Birth length less than 3rd percentile (HP:0003561)1.82356119
77Cleft eyelid (HP:0000625)1.81952392
78Dicarboxylic aciduria (HP:0003215)1.77542419
79Abnormality of dicarboxylic acid metabolism (HP:0010995)1.77542419
80Multiple enchondromatosis (HP:0005701)1.76670557
81Sparse eyelashes (HP:0000653)1.76467711
82Abnormality of the ileum (HP:0001549)1.74228683
83Horseshoe kidney (HP:0000085)1.73844457
84Opisthotonus (HP:0002179)1.72172088
85Unsteady gait (HP:0002317)1.70087072
86Sensory axonal neuropathy (HP:0003390)1.69358643
87Blindness (HP:0000618)1.66378230
88Ragged-red muscle fibers (HP:0003200)1.66136830
89Rough bone trabeculation (HP:0100670)1.65846765
90Abnormality of placental membranes (HP:0011409)1.65139518
91Amniotic constriction ring (HP:0009775)1.65139518
92Abnormality of the preputium (HP:0100587)1.63825614
93Chromosomal breakage induced by crosslinking agents (HP:0003221)1.62859949
94Hypoglycemic coma (HP:0001325)1.61585344
95Abnormality of serum amino acid levels (HP:0003112)1.61376869
96Hyperglycinemia (HP:0002154)1.57137633
97Megaloblastic anemia (HP:0001889)1.57114163
98Gliosis (HP:0002171)1.55588472
99Abnormal pupillary function (HP:0007686)1.54267911
100Sclerocornea (HP:0000647)1.53757398

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.14469184
2BUB14.36063262
3STK164.04071369
4NME23.16757640
5SRPK12.80146399
6NME12.77663338
7MST42.56563415
8ZAK2.53230321
9CDC72.43980376
10NEK12.35026693
11PBK2.33098098
12VRK12.33032638
13EIF2AK12.25030648
14BCKDK2.15851647
15TSSK61.97163315
16MAP3K121.97018790
17TESK11.89960546
18PLK31.77117889
19TTK1.69602687
20CDK191.51187630
21LIMK11.46668928
22TRIM281.44574479
23DYRK21.44173868
24EIF2AK31.43912499
25NUAK11.43455431
26TLK11.36610413
27PDK21.36408767
28TESK21.35178732
29BRSK11.27393855
30PLK11.25818403
31CSNK1G31.24137462
32DAPK11.22833032
33ARAF1.22394604
34WEE11.18238932
35WNK31.12562836
36PIM21.12516745
37MAP4K21.09027016
38PLK41.08833441
39PHKG21.06123544
40PHKG11.06123544
41AURKA1.05190799
42CSNK1G20.99980468
43AURKB0.99677647
44TAF10.96557403
45CSNK1G10.94606563
46ATR0.93075346
47CCNB10.90943770
48CHEK20.84108552
49ABL20.83903326
50PINK10.82141551
51CSNK1A1L0.80850292
52PASK0.80073952
53BMPR1B0.78367303
54CSNK2A20.74704233
55CDK80.74389774
56PRKCI0.73299177
57MINK10.73069731
58DAPK30.72109220
59CSNK2A10.67620464
60RPS6KA50.67598569
61KDR0.66427652
62ILK0.65267419
63ALK0.63468653
64MAP2K70.57551167
65BRSK20.56788379
66EIF2AK20.56198137
67CHEK10.52780840
68CDK70.52169824
69PRKCG0.51734748
70PAK10.51613610
71STK40.50728042
72CDK140.50677361
73LRRK20.50517426
74EPHA40.50473524
75AKT20.50114098
76CDK11A0.49676189
77SCYL20.49281872
78MKNK10.48064748
79WNK40.47229066
80CSNK1E0.46880204
81MAPKAPK50.45711182
82CDK180.44932629
83PLK20.44898944
84CDK150.44339094
85BRAF0.44282572
86GRK50.44071471
87PAK40.41607672
88OXSR10.40036115
89MAP3K110.39885031
90ATM0.38692293
91PAK60.38296931
92MYLK0.36647837
93DYRK30.34697947
94CSNK1A10.34058571
95UHMK10.32601053
96RPS6KB20.31493507
97MKNK20.31179607
98RPS6KA40.30779068
99GRK10.29925101
100CAMK2G0.27813257

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.57863348
2Oxidative phosphorylation_Homo sapiens_hsa001904.38341557
3Proteasome_Homo sapiens_hsa030504.32729978
4Parkinsons disease_Homo sapiens_hsa050123.84496557
5RNA polymerase_Homo sapiens_hsa030203.05966426
6DNA replication_Homo sapiens_hsa030302.94160849
7Protein export_Homo sapiens_hsa030602.77430756
8Huntingtons disease_Homo sapiens_hsa050162.74868176
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.62302939
10Mismatch repair_Homo sapiens_hsa034302.61112013
11Alzheimers disease_Homo sapiens_hsa050102.56661936
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.09073613
13Spliceosome_Homo sapiens_hsa030401.98731114
14Base excision repair_Homo sapiens_hsa034101.96936729
15Pyrimidine metabolism_Homo sapiens_hsa002401.93962670
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.93173735
17Homologous recombination_Homo sapiens_hsa034401.92960106
18Cardiac muscle contraction_Homo sapiens_hsa042601.89420322
19Nucleotide excision repair_Homo sapiens_hsa034201.70661140
20Folate biosynthesis_Homo sapiens_hsa007901.66823299
21One carbon pool by folate_Homo sapiens_hsa006701.65200643
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.64119901
23RNA transport_Homo sapiens_hsa030131.62811742
24Fatty acid elongation_Homo sapiens_hsa000621.45691483
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.44415611
26RNA degradation_Homo sapiens_hsa030181.42491139
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41662969
28Basal transcription factors_Homo sapiens_hsa030221.39865488
29Sulfur relay system_Homo sapiens_hsa041221.39768083
30Purine metabolism_Homo sapiens_hsa002301.37277974
31Fanconi anemia pathway_Homo sapiens_hsa034601.32487966
32Vitamin B6 metabolism_Homo sapiens_hsa007501.30070773
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.26079923
34Non-homologous end-joining_Homo sapiens_hsa034501.21332722
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.21080211
36Pyruvate metabolism_Homo sapiens_hsa006201.18578288
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.16435506
38Glutathione metabolism_Homo sapiens_hsa004801.13937942
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08106559
40Biosynthesis of amino acids_Homo sapiens_hsa012300.98699362
41Collecting duct acid secretion_Homo sapiens_hsa049660.96605630
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.96306136
43Carbon metabolism_Homo sapiens_hsa012000.96216846
44Cell cycle_Homo sapiens_hsa041100.90812546
45Propanoate metabolism_Homo sapiens_hsa006400.89247497
46Metabolic pathways_Homo sapiens_hsa011000.83177246
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77700132
48Selenocompound metabolism_Homo sapiens_hsa004500.76819769
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76431624
50Synaptic vesicle cycle_Homo sapiens_hsa047210.73821034
51Sulfur metabolism_Homo sapiens_hsa009200.73457778
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72473972
53mRNA surveillance pathway_Homo sapiens_hsa030150.64114490
54Peroxisome_Homo sapiens_hsa041460.61122079
55Vibrio cholerae infection_Homo sapiens_hsa051100.60604168
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60158958
57Arginine and proline metabolism_Homo sapiens_hsa003300.59415463
58Regulation of autophagy_Homo sapiens_hsa041400.59102103
59Oocyte meiosis_Homo sapiens_hsa041140.57639726
60Phototransduction_Homo sapiens_hsa047440.55587576
61Steroid biosynthesis_Homo sapiens_hsa001000.54980709
62N-Glycan biosynthesis_Homo sapiens_hsa005100.52862577
63Butanoate metabolism_Homo sapiens_hsa006500.52387851
64Nicotine addiction_Homo sapiens_hsa050330.51335939
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50987302
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48544647
67Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46179872
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.41409949
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40004215
70Pentose phosphate pathway_Homo sapiens_hsa000300.39081517
71Fructose and mannose metabolism_Homo sapiens_hsa000510.37374801
72beta-Alanine metabolism_Homo sapiens_hsa004100.36451856
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32295574
74Tyrosine metabolism_Homo sapiens_hsa003500.32129307
75p53 signaling pathway_Homo sapiens_hsa041150.31835797
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29827104
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29550993
78Epstein-Barr virus infection_Homo sapiens_hsa051690.28974467
79Arginine biosynthesis_Homo sapiens_hsa002200.26089299
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.25565952
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25395581
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24148415
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23508334
84Nitrogen metabolism_Homo sapiens_hsa009100.23217971
85Phenylalanine metabolism_Homo sapiens_hsa003600.21373323
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21296758
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20160297
88Galactose metabolism_Homo sapiens_hsa000520.20037428
89Fatty acid metabolism_Homo sapiens_hsa012120.19651428
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.16345977
91GABAergic synapse_Homo sapiens_hsa047270.16131641
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.15858009
93Tryptophan metabolism_Homo sapiens_hsa003800.14166280
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.12856500
95Alcoholism_Homo sapiens_hsa050340.12389518
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.11176974
97Olfactory transduction_Homo sapiens_hsa047400.10731046
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.09860197
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.09345541
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.07435139

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »