SNUPN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1termination of RNA polymerase III transcription (GO:0006386)5.20702978
2transcription elongation from RNA polymerase III promoter (GO:0006385)5.20702978
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.03818338
4energy coupled proton transport, down electrochemical gradient (GO:0015985)4.95903966
5ATP synthesis coupled proton transport (GO:0015986)4.95903966
6purine nucleobase biosynthetic process (GO:0009113)4.88800203
7proteasome assembly (GO:0043248)4.86904722
8mitotic metaphase plate congression (GO:0007080)4.86006851
97-methylguanosine mRNA capping (GO:0006370)4.78676614
107-methylguanosine RNA capping (GO:0009452)4.72942601
11RNA capping (GO:0036260)4.72942601
12rRNA modification (GO:0000154)4.63519825
13protein complex biogenesis (GO:0070271)4.54154187
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.43360635
15nucleobase biosynthetic process (GO:0046112)4.43231661
16mitochondrial respiratory chain complex assembly (GO:0033108)4.36294004
17transcription elongation from RNA polymerase I promoter (GO:0006362)4.18928943
18L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.15915981
19rRNA methylation (GO:0031167)4.14487589
20termination of RNA polymerase I transcription (GO:0006363)4.11229563
21respiratory chain complex IV assembly (GO:0008535)4.08962564
22transcription from RNA polymerase I promoter (GO:0006360)4.05223738
23chaperone-mediated protein transport (GO:0072321)4.04958197
24protein neddylation (GO:0045116)3.97880528
25ribosome biogenesis (GO:0042254)3.97390145
26DNA replication checkpoint (GO:0000076)3.97350126
27cullin deneddylation (GO:0010388)3.94325281
28negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.89910013
29positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.89617279
30ribosome assembly (GO:0042255)3.89617236
31regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.89457005
32anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.89338338
33maturation of 5.8S rRNA (GO:0000460)3.87900957
34protein deneddylation (GO:0000338)3.87837546
35electron transport chain (GO:0022900)3.87047455
36respiratory electron transport chain (GO:0022904)3.86354235
37metaphase plate congression (GO:0051310)3.84278438
38behavioral response to nicotine (GO:0035095)3.82981892
39transcription initiation from RNA polymerase I promoter (GO:0006361)3.77877384
40fucose catabolic process (GO:0019317)3.75043811
41L-fucose metabolic process (GO:0042354)3.75043811
42L-fucose catabolic process (GO:0042355)3.75043811
43regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.68331242
44amino acid salvage (GO:0043102)3.65379824
45L-methionine salvage (GO:0071267)3.65379824
46L-methionine biosynthetic process (GO:0071265)3.65379824
47synapsis (GO:0007129)3.62182213
48cytochrome complex assembly (GO:0017004)3.61576583
49DNA deamination (GO:0045006)3.61289138
50transcription elongation from RNA polymerase II promoter (GO:0006368)3.56609014
51exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.55835172
52RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.54966408
53tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.54966408
54negative regulation of ligase activity (GO:0051352)3.54847762
55negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.54847762
56protein-cofactor linkage (GO:0018065)3.54777273
57establishment of protein localization to mitochondrial membrane (GO:0090151)3.54505053
58nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.53978622
59regulation of spindle organization (GO:0090224)3.53311870
60DNA-templated transcription, elongation (GO:0006354)3.52119751
61positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.51835988
62pseudouridine synthesis (GO:0001522)3.46934559
63piRNA metabolic process (GO:0034587)3.46492037
64CENP-A containing nucleosome assembly (GO:0034080)3.45203652
65transcription-coupled nucleotide-excision repair (GO:0006283)3.41603022
66maturation of SSU-rRNA (GO:0030490)3.38863229
67positive regulation of ligase activity (GO:0051351)3.38815551
68ubiquinone biosynthetic process (GO:0006744)3.38224641
69regulation of cellular amino acid metabolic process (GO:0006521)3.32631827
70water-soluble vitamin biosynthetic process (GO:0042364)3.31487332
71rRNA processing (GO:0006364)3.29968062
72male meiosis I (GO:0007141)3.25484796
73regulation of exit from mitosis (GO:0007096)3.24927984
74microtubule depolymerization (GO:0007019)3.24871951
75chromatin remodeling at centromere (GO:0031055)3.23164701
76positive regulation of viral transcription (GO:0050434)3.19921305
77guanosine-containing compound biosynthetic process (GO:1901070)3.19729347
78transcription from RNA polymerase III promoter (GO:0006383)3.19406009
79DNA replication initiation (GO:0006270)3.19150645
80rRNA metabolic process (GO:0016072)3.19094939
81blastocyst development (GO:0001824)3.16566100
82establishment of chromosome localization (GO:0051303)3.15797266
83positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.15408788
84regulation of ubiquitin-protein transferase activity (GO:0051438)3.13746195
85DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.13086423
86ribonucleoprotein complex biogenesis (GO:0022613)3.12549289
87positive regulation of prostaglandin secretion (GO:0032308)3.11241939
88signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.09648736
89signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.09648736
90signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.09648736
91protein K6-linked ubiquitination (GO:0085020)3.09555228
92DNA double-strand break processing (GO:0000729)3.09370376
93microtubule polymerization or depolymerization (GO:0031109)3.09311118
94platelet dense granule organization (GO:0060155)3.08875062
95spindle checkpoint (GO:0031577)3.07484446
96intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.06692611
97signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.06692611
98GMP metabolic process (GO:0046037)3.05057151
99regulation of ligase activity (GO:0051340)3.04487796
100signal transduction involved in DNA integrity checkpoint (GO:0072401)3.03907185
101signal transduction involved in DNA damage checkpoint (GO:0072422)3.03907185
102protein targeting to mitochondrion (GO:0006626)3.03826042
103histone exchange (GO:0043486)3.03743268
104positive regulation of chromosome segregation (GO:0051984)3.03427973
105peptidyl-histidine modification (GO:0018202)3.03184428
106ubiquinone metabolic process (GO:0006743)3.02391562
107attachment of spindle microtubules to kinetochore (GO:0008608)3.00782016
108regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.00353484
109male meiosis (GO:0007140)2.99471834
110mitochondrial respiratory chain complex I assembly (GO:0032981)2.99135716
111NADH dehydrogenase complex assembly (GO:0010257)2.99135716
112mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.99135716
113signal transduction involved in cell cycle checkpoint (GO:0072395)2.99072492
114negative regulation of telomere maintenance (GO:0032205)2.98539470
115ATP biosynthetic process (GO:0006754)2.97572970
116* spliceosomal snRNP assembly (GO:0000387)2.96893434
117formation of translation preinitiation complex (GO:0001731)2.95761095
118purine nucleoside triphosphate biosynthetic process (GO:0009145)2.93972908
119hydrogen ion transmembrane transport (GO:1902600)2.93902986
120negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.93817595
121negative regulation of sister chromatid segregation (GO:0033046)2.93817595
122negative regulation of mitotic sister chromatid separation (GO:2000816)2.93817595
123negative regulation of mitotic sister chromatid segregation (GO:0033048)2.93817595
124cellular component biogenesis (GO:0044085)2.93345440
125establishment of protein localization to mitochondrion (GO:0072655)2.93185394
126rRNA catabolic process (GO:0016075)2.91967420
127cell cycle G1/S phase transition (GO:0044843)2.91562938
128G1/S transition of mitotic cell cycle (GO:0000082)2.91562938
129mitotic spindle checkpoint (GO:0071174)2.91177978
130DNA replication-independent nucleosome organization (GO:0034724)2.91127760
131DNA replication-independent nucleosome assembly (GO:0006336)2.91127760
132DNA methylation involved in gamete generation (GO:0043046)2.91092952
133tRNA processing (GO:0008033)2.89815220
134negative regulation of chromosome segregation (GO:0051985)2.89808323
135negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.88307467
136base-excision repair, AP site formation (GO:0006285)2.87856508
137meiosis I (GO:0007127)2.84485620
138purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.84019027
139DNA catabolic process, exonucleolytic (GO:0000738)2.82754666
140regulation of mitochondrial translation (GO:0070129)2.81846696
141pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.81506854
142resolution of meiotic recombination intermediates (GO:0000712)2.80773181
143cell wall macromolecule metabolic process (GO:0044036)2.78457986
144mitochondrial RNA metabolic process (GO:0000959)2.77241827
145intracellular protein transmembrane import (GO:0044743)2.75262842
146ribosomal small subunit assembly (GO:0000028)2.73948467
147preassembly of GPI anchor in ER membrane (GO:0016254)2.73452180
148proton transport (GO:0015992)2.73305605
149mannosylation (GO:0097502)2.72801689
150regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.70896272
151regulation of mitotic spindle checkpoint (GO:1903504)2.70896272
152nucleoside transmembrane transport (GO:1901642)2.70207069
153response to pheromone (GO:0019236)2.69697742
154replication fork processing (GO:0031297)2.68146366
155RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.67775774
156hydrogen transport (GO:0006818)2.67517109
157kynurenine metabolic process (GO:0070189)2.65394927
158protein localization to mitochondrion (GO:0070585)2.64221830
159nonmotile primary cilium assembly (GO:0035058)2.63205405
160protein polyglutamylation (GO:0018095)2.60134622
161quinone biosynthetic process (GO:1901663)2.58730094
162recombinational repair (GO:0000725)2.58153552
163tRNA metabolic process (GO:0006399)2.55568545
164double-strand break repair via homologous recombination (GO:0000724)2.55395266
165tRNA modification (GO:0006400)2.54335908
166DNA damage response, detection of DNA damage (GO:0042769)2.52879206
167indolalkylamine catabolic process (GO:0046218)2.50808727

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.15135711
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.33295804
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.22709832
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.15141115
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.97974706
6E2F7_22180533_ChIP-Seq_HELA_Human3.76711162
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.69803735
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.67109045
9ZNF274_21170338_ChIP-Seq_K562_Hela3.57516434
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.53047056
11MYC_18555785_ChIP-Seq_MESCs_Mouse3.42404944
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.06606812
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.04101581
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.88216286
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.85905281
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.70746196
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.59970654
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.58659730
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.56327711
20* VDR_23849224_ChIP-Seq_CD4+_Human2.54399991
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.50141397
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.41495896
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.40255477
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.39158840
25* SRF_21415370_ChIP-Seq_HL-1_Mouse2.30349875
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.20639238
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.07776304
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.05964398
29EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.05595488
30IGF1R_20145208_ChIP-Seq_DFB_Human2.03149618
31YY1_21170310_ChIP-Seq_MESCs_Mouse2.03149380
32GABP_19822575_ChIP-Seq_HepG2_Human2.01278997
33DCP1A_22483619_ChIP-Seq_HELA_Human2.00865770
34* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.00642040
35XRN2_22483619_ChIP-Seq_HELA_Human1.98910851
36ELK1_19687146_ChIP-ChIP_HELA_Human1.98569550
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.96729371
38FOXP3_21729870_ChIP-Seq_TREG_Human1.95556241
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.87413020
40FOXM1_23109430_ChIP-Seq_U2OS_Human1.85293614
41AR_21909140_ChIP-Seq_LNCAP_Human1.81940027
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79236653
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79053045
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78494630
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.78423205
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.72479299
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.65327245
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64292347
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59987733
50KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.56090535
51TP53_22573176_ChIP-Seq_HFKS_Human1.55776201
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51225579
53TTF2_22483619_ChIP-Seq_HELA_Human1.50229886
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.47806482
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42924167
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42863505
57KAP1_22055183_ChIP-Seq_ESCs_Mouse1.40604655
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.40453137
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39331558
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38815813
61* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.33081910
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31355072
63GBX2_23144817_ChIP-Seq_PC3_Human1.31259350
64ELK1_22589737_ChIP-Seq_MCF10A_Human1.30679400
65IRF1_19129219_ChIP-ChIP_H3396_Human1.29463162
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26540256
67RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25832097
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25251182
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.23981686
70FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23981686
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21008739
72AR_20517297_ChIP-Seq_VCAP_Human1.18978206
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.17293942
74CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16662566
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16484532
76P300_19829295_ChIP-Seq_ESCs_Human1.16205405
77CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.14930212
78PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13982871
79* CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.13300871
80FUS_26573619_Chip-Seq_HEK293_Human1.13067869
81GATA3_21878914_ChIP-Seq_MCF-7_Human1.12657759
82EGR1_23403033_ChIP-Seq_LIVER_Mouse1.11198269
83GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10359654
84NANOG_19829295_ChIP-Seq_ESCs_Human1.08827455
85SOX2_19829295_ChIP-Seq_ESCs_Human1.08827455
86NCOR_22424771_ChIP-Seq_293T_Human1.08667609
87KDM5A_27292631_Chip-Seq_BREAST_Human1.08425211
88E2F1_21310950_ChIP-Seq_MCF-7_Human1.07439546
89ER_23166858_ChIP-Seq_MCF-7_Human1.07229371
90MYC_18940864_ChIP-ChIP_HL60_Human1.06252205
91ERA_21632823_ChIP-Seq_H3396_Human1.05887330
92SALL1_21062744_ChIP-ChIP_HESCs_Human1.04591572
93SOX17_20123909_ChIP-Seq_XEN_Mouse1.03932395
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03405823
95GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.01081316
96EWS_26573619_Chip-Seq_HEK293_Human1.00624687
97SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98168568
98VDR_22108803_ChIP-Seq_LS180_Human0.96795101
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96388702
100FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94881962
101E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94761044
102HOXB7_26014856_ChIP-Seq_BT474_Human0.93851007
103NANOG_20526341_ChIP-Seq_ESCs_Human0.93727411
104NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.93463288
105SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.93081624
106EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.92387211
107FOXH1_21741376_ChIP-Seq_EPCs_Human0.92093156
108UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92035384
109CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91334791
110KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91088207
111MYC_19829295_ChIP-Seq_ESCs_Human0.91067391
112ZFX_18555785_ChIP-Seq_MESCs_Mouse0.90659096
113* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89404960
114* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.88477875
115SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.87704907
116PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.86374569
117CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.86363991
118RBPJ_21746931_ChIP-Seq_IB4_Human0.86197654
119PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.86053609
120ZFP57_27257070_Chip-Seq_ESCs_Mouse0.86017246
121BMI1_23680149_ChIP-Seq_NPCS_Mouse0.85929652
122ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85156552
123TP63_19390658_ChIP-ChIP_HaCaT_Human0.83812669
124CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.83335840
125CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.80387653
126DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.77175242
127* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.76581748
128POU3F2_20337985_ChIP-ChIP_501MEL_Human0.76079420
129TAF15_26573619_Chip-Seq_HEK293_Human0.75166353
130TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.72561531
131SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.72520931
132* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.72520098
133* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.68847004
134* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.68504083
135* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.67296034
136* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.67225594
137* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67007974
138KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.66892827
139KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.66892827
140KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.66892827
141CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.63932805

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.91630229
2MP0003718_maternal_effect3.78053838
3MP0008877_abnormal_DNA_methylation3.68677525
4MP0008057_abnormal_DNA_replication3.50547300
5MP0003111_abnormal_nucleus_morphology3.47690297
6MP0010094_abnormal_chromosome_stability3.38149061
7MP0004957_abnormal_blastocyst_morpholog3.27433283
8MP0008058_abnormal_DNA_repair3.11991294
9MP0003077_abnormal_cell_cycle2.99207181
10MP0008260_abnormal_autophagy2.61766519
11MP0001529_abnormal_vocalization2.57175398
12MP0002837_dystrophic_cardiac_calcinosis2.38718360
13MP0008932_abnormal_embryonic_tissue2.38022756
14MP0003011_delayed_dark_adaptation2.36897181
15MP0006292_abnormal_olfactory_placode2.31752119
16MP0003646_muscle_fatigue2.26295308
17MP0001905_abnormal_dopamine_level2.23850333
18MP0003123_paternal_imprinting2.13604017
19MP0008007_abnormal_cellular_replicative2.13521013
20MP0005551_abnormal_eye_electrophysiolog2.12919280
21MP0008875_abnormal_xenobiotic_pharmacok2.12834844
22MP0001968_abnormal_touch/_nociception1.98773658
23MP0003195_calcinosis1.95909738
24MP0002277_abnormal_respiratory_mucosa1.94278834
25MP0005084_abnormal_gallbladder_morpholo1.92643867
26MP0005451_abnormal_body_composition1.90384096
27MP0003806_abnormal_nucleotide_metabolis1.90256500
28MP0002102_abnormal_ear_morphology1.84777090
29MP0003786_premature_aging1.81879158
30MP0003136_yellow_coat_color1.78009727
31MP0002210_abnormal_sex_determination1.76900753
32MP0006072_abnormal_retinal_apoptosis1.74005567
33MP0004147_increased_porphyrin_level1.71799650
34MP0001929_abnormal_gametogenesis1.67070267
35MP0001730_embryonic_growth_arrest1.65083535
36MP0008872_abnormal_physiological_respon1.59866132
37MP0003315_abnormal_perineum_morphology1.56003117
38MP0002132_abnormal_respiratory_system1.55240955
39MP0001188_hyperpigmentation1.52077949
40MP0005075_abnormal_melanosome_morpholog1.49261100
41MP0003880_abnormal_central_pattern1.47924500
42MP0005367_renal/urinary_system_phenotyp1.47082349
43MP0000516_abnormal_urinary_system1.47082349
44MP0001145_abnormal_male_reproductive1.46041973
45MP0004145_abnormal_muscle_electrophysio1.45267083
46MP0000653_abnormal_sex_gland1.39568445
47MP0001661_extended_life_span1.39462514
48MP0003937_abnormal_limbs/digits/tail_de1.31895724
49MP0005332_abnormal_amino_acid1.29303353
50MP0005645_abnormal_hypothalamus_physiol1.29261585
51MP0003698_abnormal_male_reproductive1.29203383
52MP0003950_abnormal_plasma_membrane1.28663780
53MP0009697_abnormal_copulation1.28449404
54MP0005253_abnormal_eye_physiology1.27761522
55MP0001984_abnormal_olfaction1.26622268
56MP0002876_abnormal_thyroid_physiology1.24570384
57MP0000631_abnormal_neuroendocrine_gland1.22385308
58MP0001485_abnormal_pinna_reflex1.21201316
59MP0002653_abnormal_ependyma_morphology1.20401069
60MP0009379_abnormal_foot_pigmentation1.19422344
61MP0004885_abnormal_endolymph1.17406340
62MP0002138_abnormal_hepatobiliary_system1.17243549
63MP0005410_abnormal_fertilization1.15049841
64MP0002095_abnormal_skin_pigmentation1.14124357
65MP0002163_abnormal_gland_morphology1.13377103
66MP0009745_abnormal_behavioral_response1.11398115
67MP0005395_other_phenotype1.09631240
68MP0005360_urolithiasis1.09178190
69MP0001346_abnormal_lacrimal_gland1.07547050
70MP0001986_abnormal_taste_sensitivity1.07198057
71MP0000350_abnormal_cell_proliferation1.06492261
72MP0003938_abnormal_ear_development1.04954010
73MP0010386_abnormal_urinary_bladder1.04349194
74MP0008995_early_reproductive_senescence1.03080254
75MP0001293_anophthalmia1.02278499
76MP0000647_abnormal_sebaceous_gland1.01464532
77MP0006036_abnormal_mitochondrial_physio1.01384281
78MP0002160_abnormal_reproductive_system1.01309659
79MP0003186_abnormal_redox_activity1.00663697
80MP0001542_abnormal_bone_strength0.99502309
81MP0000372_irregular_coat_pigmentation0.98854207
82MP0005379_endocrine/exocrine_gland_phen0.98528443
83MP0005171_absent_coat_pigmentation0.98301820
84MP0004133_heterotaxia0.98060113
85MP0002161_abnormal_fertility/fecundity0.96441115
86MP0002736_abnormal_nociception_after0.96137337
87MP0002735_abnormal_chemical_nociception0.95949131
88MP0000427_abnormal_hair_cycle0.94148734
89MP0005389_reproductive_system_phenotype0.93282332
90MP0001963_abnormal_hearing_physiology0.92317582
91MP0009333_abnormal_splenocyte_physiolog0.92116913
92MP0001672_abnormal_embryogenesis/_devel0.91726039
93MP0005380_embryogenesis_phenotype0.91726039
94MP0001970_abnormal_pain_threshold0.90378401
95MP0003221_abnormal_cardiomyocyte_apopto0.90308068
96MP0001697_abnormal_embryo_size0.89997513
97MP0004043_abnormal_pH_regulation0.89499938
98MP0000358_abnormal_cell_content/0.88193130
99MP0002734_abnormal_mechanical_nocicepti0.88158757
100MP0001119_abnormal_female_reproductive0.88060630
101MP0000015_abnormal_ear_pigmentation0.87782878
102MP0002272_abnormal_nervous_system0.87451051
103MP0000920_abnormal_myelination0.87220598
104MP0006035_abnormal_mitochondrial_morpho0.86846536
105MP0002080_prenatal_lethality0.85466659
106MP0003121_genomic_imprinting0.83658447
107MP0000749_muscle_degeneration0.82890550
108MP0002733_abnormal_thermal_nociception0.82447643
109MP0002938_white_spotting0.82332233
110MP0005377_hearing/vestibular/ear_phenot0.82256114
111MP0003878_abnormal_ear_physiology0.82256114
112MP0005174_abnormal_tail_pigmentation0.81530920
113MP0003879_abnormal_hair_cell0.80575583
114MP0005408_hypopigmentation0.80252481
115MP0001919_abnormal_reproductive_system0.80204484
116MP0005195_abnormal_posterior_eye0.77623615
117MP0004270_analgesia0.77347214
118MP0002751_abnormal_autonomic_nervous0.77267666
119MP0000566_synostosis0.77168730
120MP0002085_abnormal_embryonic_tissue0.76870663
121MP0000026_abnormal_inner_ear0.75993248
122MP0000569_abnormal_digit_pigmentation0.75059936
123MP0001486_abnormal_startle_reflex0.74981308
124MP0002557_abnormal_social/conspecific_i0.74835818
125MP0008775_abnormal_heart_ventricle0.74287492
126MP0002282_abnormal_trachea_morphology0.74274101
127MP0004215_abnormal_myocardial_fiber0.73316687
128MP0008789_abnormal_olfactory_epithelium0.72245057
129MP0002928_abnormal_bile_duct0.71736599
130MP0003699_abnormal_female_reproductive0.71429541
131MP0004142_abnormal_muscle_tone0.71029775
132MP0005646_abnormal_pituitary_gland0.70608589
133MP0004742_abnormal_vestibular_system0.70447122
134MP0002572_abnormal_emotion/affect_behav0.70227023
135MP0004381_abnormal_hair_follicle0.68916532
136MP0000230_abnormal_systemic_arterial0.67885774
137MP0006276_abnormal_autonomic_nervous0.67390614
138MP0001764_abnormal_homeostasis0.67353633
139MP0002752_abnormal_somatic_nervous0.66728005
140MP0002067_abnormal_sensory_capabilities0.66604007
141MP0000049_abnormal_middle_ear0.66520483
142MP0003936_abnormal_reproductive_system0.66093979
143MP0000313_abnormal_cell_death0.65646825
144MP0002638_abnormal_pupillary_reflex0.64013233
145MP0002269_muscular_atrophy0.63999016
146MP0003984_embryonic_growth_retardation0.63044379
147MP0003632_abnormal_nervous_system0.63012388
148MP0009250_abnormal_appendicular_skeleto0.61734291
149MP0005409_darkened_coat_color0.61380621
150MP0009046_muscle_twitch0.60956741

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.48549653
2Cerebral hypomyelination (HP:0006808)4.74619887
3Breast hypoplasia (HP:0003187)4.28581099
4Molar tooth sign on MRI (HP:0002419)3.94412334
5Abnormality of midbrain morphology (HP:0002418)3.94412334
6Abnormality of glycolysis (HP:0004366)3.75992395
7Increased serum pyruvate (HP:0003542)3.75992395
8Acute necrotizing encephalopathy (HP:0006965)3.41702039
9Hypoplasia of the capital femoral epiphysis (HP:0003090)3.26242047
10Irregular epiphyses (HP:0010582)3.18711315
11Abnormality of the labia minora (HP:0012880)3.11155668
12Patellar aplasia (HP:0006443)3.11025776
13Congenital stationary night blindness (HP:0007642)2.96926532
14Aplasia/Hypoplasia of the patella (HP:0006498)2.96169346
15Rough bone trabeculation (HP:0100670)2.96066379
16Carpal bone hypoplasia (HP:0001498)2.94867621
17Mitochondrial inheritance (HP:0001427)2.93267014
18Abnormal mitochondria in muscle tissue (HP:0008316)2.92999643
19CNS hypomyelination (HP:0003429)2.92678655
20Cerebral edema (HP:0002181)2.91603042
21Adrenal hypoplasia (HP:0000835)2.87999250
22Absent epiphyses (HP:0010577)2.86878978
23Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.86878978
243-Methylglutaconic aciduria (HP:0003535)2.84743499
25Nephronophthisis (HP:0000090)2.81791997
26Type II lissencephaly (HP:0007260)2.79168170
27Increased CSF lactate (HP:0002490)2.74083952
28Pancreatic fibrosis (HP:0100732)2.72679291
29Optic disc pallor (HP:0000543)2.68521512
30Abnormal number of erythroid precursors (HP:0012131)2.67345470
31Acute encephalopathy (HP:0006846)2.63144329
32Impulsivity (HP:0100710)2.59978197
33Progressive macrocephaly (HP:0004481)2.58254867
34Aplasia/Hypoplasia involving the musculature (HP:0001460)2.55916601
35Pendular nystagmus (HP:0012043)2.55693515
36Hepatocellular necrosis (HP:0001404)2.51502528
37Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.51131131
38Decreased activity of mitochondrial respiratory chain (HP:0008972)2.51131131
39Abnormal trabecular bone morphology (HP:0100671)2.50504681
40Increased hepatocellular lipid droplets (HP:0006565)2.46510778
41Attenuation of retinal blood vessels (HP:0007843)2.45667893
42Type 2 muscle fiber atrophy (HP:0003554)2.43933092
43Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.38705909
44Increased intramyocellular lipid droplets (HP:0012240)2.38698312
45Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.37475620
46Abnormality of cells of the erythroid lineage (HP:0012130)2.36275204
47Increased serum lactate (HP:0002151)2.36193896
48Abnormality of the renal cortex (HP:0011035)2.34904883
49Parakeratosis (HP:0001036)2.34430379
50Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.34147529
51Degeneration of the lateral corticospinal tracts (HP:0002314)2.31738353
52Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.31738353
53Secondary amenorrhea (HP:0000869)2.31652689
54Abnormality of the renal medulla (HP:0100957)2.29828719
55Prolonged neonatal jaundice (HP:0006579)2.28152843
56Abnormality of the preputium (HP:0100587)2.26049003
57Sclerocornea (HP:0000647)2.24937749
58Abnormal spermatogenesis (HP:0008669)2.24175553
59Renal Fanconi syndrome (HP:0001994)2.22814889
60Aplastic anemia (HP:0001915)2.22543851
61Absent rod-and cone-mediated responses on ERG (HP:0007688)2.21837507
62Increased muscle lipid content (HP:0009058)2.21612687
63Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.18839911
64Amniotic constriction ring (HP:0009775)2.18670880
65Abnormality of placental membranes (HP:0011409)2.18670880
66Absent radius (HP:0003974)2.18315275
67Respiratory failure (HP:0002878)2.18169262
68Leukodystrophy (HP:0002415)2.17948932
69Aplasia involving forearm bones (HP:0009822)2.17941917
70Absent forearm bone (HP:0003953)2.17941917
71Abnormality of alanine metabolism (HP:0010916)2.17178472
72Hyperalaninemia (HP:0003348)2.17178472
73Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.17178472
74Lethargy (HP:0001254)2.16857731
75Abolished electroretinogram (ERG) (HP:0000550)2.16815658
76Oral leukoplakia (HP:0002745)2.16520821
77Hypoplastic pelvis (HP:0008839)2.15615316
78Small epiphyses (HP:0010585)2.14894820
79Oligodactyly (hands) (HP:0001180)2.14106648
80Methylmalonic acidemia (HP:0002912)2.13955055
81Methylmalonic aciduria (HP:0012120)2.13722267
82Cystic liver disease (HP:0006706)2.13611418
83Chronic hepatic failure (HP:0100626)2.13573764
84Meckel diverticulum (HP:0002245)2.13390922
85Retinal dysplasia (HP:0007973)2.13346251
86Cerebellar dysplasia (HP:0007033)2.11000597
87Abnormal rod and cone electroretinograms (HP:0008323)2.09946834
88Premature graying of hair (HP:0002216)2.09837576
89Medial flaring of the eyebrow (HP:0010747)2.09406705
90Premature ovarian failure (HP:0008209)2.08313237
91Decreased central vision (HP:0007663)2.06929944
92Hyperglycinemia (HP:0002154)2.05573511
93Delusions (HP:0000746)2.05441444
94Breast aplasia (HP:0100783)2.03569027
95Pancreatic cysts (HP:0001737)2.03475441
96Renal cortical cysts (HP:0000803)2.02585591
97Hepatic necrosis (HP:0002605)2.01969678
98Decreased electroretinogram (ERG) amplitude (HP:0000654)2.00784033
99Congenital, generalized hypertrichosis (HP:0004540)1.99964042
100Abnormality of renal resorption (HP:0011038)1.98376746
101Abnormality of urine glucose concentration (HP:0011016)1.98111726
102Glycosuria (HP:0003076)1.98111726
103Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.97936718
104Abnormal protein N-linked glycosylation (HP:0012347)1.97936718
105Abnormal protein glycosylation (HP:0012346)1.97936718
106Abnormal glycosylation (HP:0012345)1.97936718
107Muscle fiber atrophy (HP:0100295)1.97634670
108Abnormality of the ileum (HP:0001549)1.96508621
109Postnatal microcephaly (HP:0005484)1.96267887
110Chromosomal breakage induced by crosslinking agents (HP:0003221)1.95270543
111Male pseudohermaphroditism (HP:0000037)1.95092397
112Cleft eyelid (HP:0000625)1.95091426
113Chromsome breakage (HP:0040012)1.93865604
114Abnormality of chromosome stability (HP:0003220)1.93676498
115Congenital primary aphakia (HP:0007707)1.93403372
116Gait imbalance (HP:0002141)1.93389307
117CNS demyelination (HP:0007305)1.93337384
118Lipid accumulation in hepatocytes (HP:0006561)1.92996286
119Inability to walk (HP:0002540)1.92534854
120Aplasia/Hypoplasia of the tongue (HP:0010295)1.92405282
121Abnormality of serum amino acid levels (HP:0003112)1.92114900
122Anencephaly (HP:0002323)1.90808027
123Aplasia/Hypoplasia of the tibia (HP:0005772)1.88746377
124Bone marrow hypocellularity (HP:0005528)1.87809506
125Exercise intolerance (HP:0003546)1.86994700
126Tubular atrophy (HP:0000092)1.86421148
127Aplasia/Hypoplasia of the breasts (HP:0010311)1.86169438
128Delayed epiphyseal ossification (HP:0002663)1.85974470
129Nephrogenic diabetes insipidus (HP:0009806)1.84313989
130Capillary hemangiomas (HP:0005306)1.83958858
131Short tibia (HP:0005736)1.83705180
132Reticulocytopenia (HP:0001896)1.83668876
133Absent thumb (HP:0009777)1.83143243
134Abnormal biliary tract physiology (HP:0012439)1.83096595
135Bile duct proliferation (HP:0001408)1.83096595
136Aplasia/hypoplasia of the uterus (HP:0008684)1.82895757
137Split foot (HP:0001839)1.82693167
138True hermaphroditism (HP:0010459)1.82390640
139Hypothermia (HP:0002045)1.81633413
140Horseshoe kidney (HP:0000085)1.79743404
141Abnormality of the clitoris (HP:0000056)1.79661435
142Abnormalities of placenta or umbilical cord (HP:0001194)1.79479665
143Genital tract atresia (HP:0001827)1.79342654
144Concave nail (HP:0001598)1.79334235
145Lissencephaly (HP:0001339)1.78977110
146Female pseudohermaphroditism (HP:0010458)1.78710945
147Median cleft lip (HP:0000161)1.77264950
148Lactic acidosis (HP:0003128)1.77152305
149Hypoplasia of the uterus (HP:0000013)1.76400865
150Keratoconus (HP:0000563)1.75647681
151Increased corneal curvature (HP:0100692)1.75647681
152Abnormality of the umbilical cord (HP:0010881)1.75619200
153Aplasia/Hypoplasia of the uvula (HP:0010293)1.75588043
154Vaginal atresia (HP:0000148)1.75459984
155Furrowed tongue (HP:0000221)1.75233363
156Autoamputation (HP:0001218)1.73652405
157Poor coordination (HP:0002370)1.72476940
158Type I transferrin isoform profile (HP:0003642)1.71768620
159Respiratory difficulties (HP:0002880)1.71443450
160Spastic paraparesis (HP:0002313)1.71197483
161Abnormal lung lobation (HP:0002101)1.70279430
162Exertional dyspnea (HP:0002875)1.69886699

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.97226865
2STK163.79998333
3WEE13.55366371
4TLK13.53830520
5TSSK62.92350393
6EIF2AK12.83475905
7FRK2.66126724
8SRPK12.61616946
9BRSK22.58033746
10VRK22.42951472
11PLK42.38100470
12EIF2AK32.37705469
13WNK32.09202898
14GRK11.90753820
15PLK31.88189514
16MAP4K21.87938722
17ARAF1.86201268
18STK391.84910884
19AKT31.78269735
20BRSK11.78007720
21CASK1.77835395
22VRK11.77756616
23MKNK21.74658122
24CDC71.73116200
25PLK11.67954420
26MKNK11.66871266
27WNK41.60173071
28BRAF1.51740380
29PNCK1.46496088
30BCR1.45101316
31TTK1.43833111
32NEK61.42812884
33CCNB11.38255407
34OXSR11.36074278
35CSNK1G31.32663019
36DYRK21.27315886
37NUAK11.25096005
38NME21.22733632
39PHKG21.21805571
40PHKG11.21805571
41AURKA1.18278266
42ZAK1.16942779
43TRIM281.14533268
44CHEK21.14265537
45DYRK31.13184739
46TESK21.10456516
47MST41.10259638
48NME11.07711159
49ADRBK11.07110940
50ACVR1B1.06545110
51AURKB1.05677284
52INSRR1.03862262
53CSNK1A1L1.02755662
54STK38L1.00873771
55PDK41.00805841
56PDK31.00805841
57MAPKAPK31.00283229
58TAOK30.98612366
59PIM20.97607610
60PDK20.96372456
61TXK0.96221030
62CSNK1G10.96043808
63TGFBR10.94340765
64CDK70.93723755
65NEK20.93018059
66PBK0.92500924
67TNIK0.92214136
68PRPF4B0.90254043
69MAP3K40.88435161
70ADRBK20.88073922
71EIF2AK20.86951163
72CDK30.86240137
73OBSCN0.85681815
74TIE10.84397341
75CSNK1G20.81405629
76PLK20.79399905
77CDK80.78907062
78PINK10.78526251
79MELK0.77809313
80MAP3K120.75024837
81PRKCI0.74079531
82CHEK10.73949503
83IKBKB0.71067168
84NEK10.70700519
85ATR0.69604575
86LATS20.68389770
87FES0.67199040
88PRKCQ0.63628448
89BCKDK0.63539811
90DAPK10.61023263
91LIMK10.60737338
92DAPK20.60232459
93CSNK2A10.59957847
94PKN10.55864971
95MUSK0.55785704
96RAF10.54863147
97RPS6KA50.54363082
98CSNK2A20.53805729
99PAK10.53412956
100CAMKK20.52803728
101MAPK130.51769320
102ERBB40.51141971
103MAP3K110.50012140
104CAMK2B0.49073866
105STK30.48601788
106PRKCE0.48037156
107CDK10.47637490
108BMPR1B0.45782652
109MAPKAPK50.45403209
110ATM0.44677185
111PAK30.43222141
112CDK190.40703073
113CSNK1A10.40684090
114BMPR20.40431196
115NLK0.40188060
116TAF10.40011646
117CDK20.39814458
118PASK0.37314162
119MAP2K70.35713566
120CSNK1E0.35695788
121MARK30.34814739
122PRKCG0.34671886
123EPHA20.34627341
124ABL20.32328610
125CAMK2G0.32096317
126YES10.29732064
127LATS10.28737434
128RPS6KA40.27935351
129GRK70.25495484
130CAMK2D0.23979050
131MAP3K80.23413661

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030205.06425053
2Proteasome_Homo sapiens_hsa030504.20277220
3Vitamin B6 metabolism_Homo sapiens_hsa007503.86892949
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.84112541
5DNA replication_Homo sapiens_hsa030302.81386115
6Basal transcription factors_Homo sapiens_hsa030222.77832725
7Mismatch repair_Homo sapiens_hsa034302.57154977
8Pyrimidine metabolism_Homo sapiens_hsa002402.54955806
9* RNA transport_Homo sapiens_hsa030132.51332294
10Homologous recombination_Homo sapiens_hsa034402.51231074
11Protein export_Homo sapiens_hsa030602.49859348
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.46601422
13Nucleotide excision repair_Homo sapiens_hsa034202.35659392
14Spliceosome_Homo sapiens_hsa030402.31721634
15Oxidative phosphorylation_Homo sapiens_hsa001902.27869234
16Cell cycle_Homo sapiens_hsa041102.24464733
17Ribosome_Homo sapiens_hsa030102.07877222
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.03262535
19Fanconi anemia pathway_Homo sapiens_hsa034601.89670683
20Purine metabolism_Homo sapiens_hsa002301.88556278
21Parkinsons disease_Homo sapiens_hsa050121.85331715
22Nitrogen metabolism_Homo sapiens_hsa009101.83611420
23RNA degradation_Homo sapiens_hsa030181.77064602
24Steroid biosynthesis_Homo sapiens_hsa001001.73420365
25Base excision repair_Homo sapiens_hsa034101.73162864
26Huntingtons disease_Homo sapiens_hsa050161.72663017
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.68675775
28Non-homologous end-joining_Homo sapiens_hsa034501.67291375
29Selenocompound metabolism_Homo sapiens_hsa004501.58586419
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.52249379
31Regulation of autophagy_Homo sapiens_hsa041401.47817617
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44132967
33Fatty acid elongation_Homo sapiens_hsa000621.39927141
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.37676617
35Caffeine metabolism_Homo sapiens_hsa002321.32638323
36Tryptophan metabolism_Homo sapiens_hsa003801.27996436
37Alzheimers disease_Homo sapiens_hsa050101.19650807
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14408112
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12753794
40Oocyte meiosis_Homo sapiens_hsa041141.11827042
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.08724915
42Peroxisome_Homo sapiens_hsa041461.07126510
43mRNA surveillance pathway_Homo sapiens_hsa030151.05269421
44p53 signaling pathway_Homo sapiens_hsa041151.02622405
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01125816
46Folate biosynthesis_Homo sapiens_hsa007901.00387571
47Chemical carcinogenesis_Homo sapiens_hsa052040.96753616
48Epstein-Barr virus infection_Homo sapiens_hsa051690.96075108
49Ether lipid metabolism_Homo sapiens_hsa005650.90291457
50Pentose phosphate pathway_Homo sapiens_hsa000300.90287281
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.85588523
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80149303
53Collecting duct acid secretion_Homo sapiens_hsa049660.79097672
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77541603
55Olfactory transduction_Homo sapiens_hsa047400.76933321
56Sphingolipid metabolism_Homo sapiens_hsa006000.75389626
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.74665080
58Metabolic pathways_Homo sapiens_hsa011000.73989530
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70478260
60Linoleic acid metabolism_Homo sapiens_hsa005910.70264839
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68745386
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68531067
63One carbon pool by folate_Homo sapiens_hsa006700.67346253
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67100273
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64746179
66Glutathione metabolism_Homo sapiens_hsa004800.64517893
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63801949
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63514530
69Autoimmune thyroid disease_Homo sapiens_hsa053200.63116331
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62819452
71Biosynthesis of amino acids_Homo sapiens_hsa012300.62443149
72Arginine and proline metabolism_Homo sapiens_hsa003300.62318584
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61438540
74Vitamin digestion and absorption_Homo sapiens_hsa049770.59096666
75beta-Alanine metabolism_Homo sapiens_hsa004100.58488465
76Retinol metabolism_Homo sapiens_hsa008300.57313884
77Cardiac muscle contraction_Homo sapiens_hsa042600.57001110
78Arachidonic acid metabolism_Homo sapiens_hsa005900.56017663
79Primary immunodeficiency_Homo sapiens_hsa053400.55456908
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.54562942
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.53842333
82Asthma_Homo sapiens_hsa053100.52392029
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51071486
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49988673
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.47734325
86Mineral absorption_Homo sapiens_hsa049780.45386616
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43021404
88Phototransduction_Homo sapiens_hsa047440.42722870
89Rheumatoid arthritis_Homo sapiens_hsa053230.42716419
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42675116
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42380749
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40595395
93Taste transduction_Homo sapiens_hsa047420.38991190
94Sulfur metabolism_Homo sapiens_hsa009200.34201769
95Fatty acid degradation_Homo sapiens_hsa000710.33209941
96Vibrio cholerae infection_Homo sapiens_hsa051100.33047953
97Fat digestion and absorption_Homo sapiens_hsa049750.32908431
98Circadian rhythm_Homo sapiens_hsa047100.32221795
99Systemic lupus erythematosus_Homo sapiens_hsa053220.32023622
100Nicotine addiction_Homo sapiens_hsa050330.31401147
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.29112532
102Morphine addiction_Homo sapiens_hsa050320.28923744
103Fatty acid metabolism_Homo sapiens_hsa012120.26580213
104Pyruvate metabolism_Homo sapiens_hsa006200.25990298
105Antigen processing and presentation_Homo sapiens_hsa046120.22725055
106Carbon metabolism_Homo sapiens_hsa012000.22490292
107Sulfur relay system_Homo sapiens_hsa041220.20360169
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19546709
109Fructose and mannose metabolism_Homo sapiens_hsa000510.18642574
110Butanoate metabolism_Homo sapiens_hsa006500.18226319
111TGF-beta signaling pathway_Homo sapiens_hsa043500.14949657
112Allograft rejection_Homo sapiens_hsa053300.14784422
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.11287581
114Hedgehog signaling pathway_Homo sapiens_hsa043400.11237943
115Serotonergic synapse_Homo sapiens_hsa047260.10981242
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.10643585
117Phagosome_Homo sapiens_hsa041450.09800132
118Histidine metabolism_Homo sapiens_hsa003400.07507235
119Viral carcinogenesis_Homo sapiens_hsa052030.06418774
120Herpes simplex infection_Homo sapiens_hsa051680.05065813
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.04819090
122Tyrosine metabolism_Homo sapiens_hsa003500.04662252
123Propanoate metabolism_Homo sapiens_hsa006400.04573835
124Intestinal immune network for IgA production_Homo sapiens_hsa046720.04012202
125Synaptic vesicle cycle_Homo sapiens_hsa047210.01462222
126Maturity onset diabetes of the young_Homo sapiens_hsa049500.01267164
127Cyanoamino acid metabolism_Homo sapiens_hsa004600.01118325
128Graft-versus-host disease_Homo sapiens_hsa05332-0.0149148
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.0094850
130Citrate cycle (TCA cycle)_Homo sapiens_hsa00020-0.0056956

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