SNW1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)5.11238369
2axon ensheathment in central nervous system (GO:0032291)5.11238369
3protein neddylation (GO:0045116)4.26126106
4ribosome assembly (GO:0042255)4.21689097
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.06588307
6establishment of integrated proviral latency (GO:0075713)3.97307101
7telomere maintenance via semi-conservative replication (GO:0032201)3.94366888
8energy coupled proton transport, down electrochemical gradient (GO:0015985)3.72895341
9ATP synthesis coupled proton transport (GO:0015986)3.72895341
10rRNA modification (GO:0000154)3.67854333
11establishment of viral latency (GO:0019043)3.63009355
12kinetochore organization (GO:0051383)3.58148068
13maturation of SSU-rRNA (GO:0030490)3.57286325
14ribosomal small subunit biogenesis (GO:0042274)3.51016070
15purine nucleobase biosynthetic process (GO:0009113)3.50947492
16telomere maintenance via recombination (GO:0000722)3.45404511
17spliceosomal snRNP assembly (GO:0000387)3.41383162
18negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.38362918
19rRNA methylation (GO:0031167)3.30800578
20protein localization to chromosome, centromeric region (GO:0071459)3.28327224
21DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.28023728
22double-strand break repair via nonhomologous end joining (GO:0006303)3.27320947
23non-recombinational repair (GO:0000726)3.27320947
24ribosomal small subunit assembly (GO:0000028)3.25182730
25negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.23735742
26negative regulation of ligase activity (GO:0051352)3.23735742
27signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.23450535
28intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.23450535
29RNA capping (GO:0036260)3.22824959
307-methylguanosine RNA capping (GO:0009452)3.22824959
317-methylguanosine mRNA capping (GO:0006370)3.20823731
32DNA ligation (GO:0006266)3.20395106
33chaperone-mediated protein transport (GO:0072321)3.20284625
34kinetochore assembly (GO:0051382)3.19773096
35positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.18158352
36signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.16891903
37signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.16891903
38signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.16891903
39nuclear pore complex assembly (GO:0051292)3.16662738
40signal transduction involved in cell cycle checkpoint (GO:0072395)3.15959991
41signal transduction involved in DNA damage checkpoint (GO:0072422)3.15742492
42signal transduction involved in DNA integrity checkpoint (GO:0072401)3.15742492
43DNA replication checkpoint (GO:0000076)3.15412780
44regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.15283955
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.14473130
46translational initiation (GO:0006413)3.14170506
47mitotic sister chromatid segregation (GO:0000070)3.12660003
48mitotic sister chromatid cohesion (GO:0007064)3.11157145
49nucleobase biosynthetic process (GO:0046112)3.10419096
50spindle checkpoint (GO:0031577)3.09807036
51DNA double-strand break processing (GO:0000729)3.09737224
52ribonucleoprotein complex biogenesis (GO:0022613)3.09465251
53anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.09325603
54transcription elongation from RNA polymerase III promoter (GO:0006385)3.08260858
55termination of RNA polymerase III transcription (GO:0006386)3.08260858
56regulation of mitochondrial translation (GO:0070129)3.07800219
57translation (GO:0006412)3.07403358
58rRNA metabolic process (GO:0016072)3.06543590
59mitotic spindle checkpoint (GO:0071174)3.05333515
60long-chain fatty acid biosynthetic process (GO:0042759)3.02436837
61DNA catabolic process, exonucleolytic (GO:0000738)3.01049071
62sister chromatid segregation (GO:0000819)3.00255958
63nuclear pore organization (GO:0006999)2.99672558
64telomere maintenance via telomere lengthening (GO:0010833)2.99054306
65establishment of protein localization to mitochondrial membrane (GO:0090151)2.98123219
66CENP-A containing nucleosome assembly (GO:0034080)2.97069995
67cullin deneddylation (GO:0010388)2.96280975
68negative regulation of sister chromatid segregation (GO:0033046)2.96038782
69negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.96038782
70negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.96038782
71negative regulation of mitotic sister chromatid segregation (GO:0033048)2.96038782
72negative regulation of mitotic sister chromatid separation (GO:2000816)2.96038782
73regulation of DNA endoreduplication (GO:0032875)2.94623512
74negative regulation of protein ubiquitination (GO:0031397)2.94555723
75positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.94111222
76tRNA aminoacylation for protein translation (GO:0006418)2.93953840
77antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.93702971
78DNA unwinding involved in DNA replication (GO:0006268)2.92512735
79activated T cell proliferation (GO:0050798)2.88967890
80regulation of cellular amino acid metabolic process (GO:0006521)2.88697360
81protein deneddylation (GO:0000338)2.85863482
82histone H2B ubiquitination (GO:0033523)2.79310955
83transcription elongation from RNA polymerase I promoter (GO:0006362)2.77788476
84chromatin remodeling at centromere (GO:0031055)2.77695117
85regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.76510573
86fatty acid elongation (GO:0030497)2.72253758
87formation of translation preinitiation complex (GO:0001731)2.70701299
88positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.68432203
89transcription-coupled nucleotide-excision repair (GO:0006283)2.67312497
90DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.66318742
91myelination (GO:0042552)2.64936958
92nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.64372733
93mitotic metaphase plate congression (GO:0007080)2.64198141
94spliceosomal complex assembly (GO:0000245)2.63817983
95cotranslational protein targeting to membrane (GO:0006613)2.63203745
96microtubule polymerization or depolymerization (GO:0031109)2.63113693
97DNA strand elongation involved in DNA replication (GO:0006271)2.61556193
98ensheathment of neurons (GO:0007272)2.61171883
99axon ensheathment (GO:0008366)2.61171883
100viral transcription (GO:0019083)2.58929692
101positive regulation of ligase activity (GO:0051351)2.57853413
102positive regulation of chromosome segregation (GO:0051984)2.57523490
103DNA replication-dependent nucleosome organization (GO:0034723)2.53604169
104DNA replication-dependent nucleosome assembly (GO:0006335)2.53604169
105translational termination (GO:0006415)2.52461515
106protein targeting to ER (GO:0045047)2.52215794
107regulation of ubiquitin-protein transferase activity (GO:0051438)2.52033101
108DNA strand elongation (GO:0022616)2.50702769
109DNA topological change (GO:0006265)2.50291389
110SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.50056527
111transcription elongation from RNA polymerase II promoter (GO:0006368)2.49361195
112positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.47944550
113histone exchange (GO:0043486)2.47882029
114positive regulation of interleukin-17 production (GO:0032740)2.47568081
115attachment of spindle microtubules to kinetochore (GO:0008608)2.47161344
116ribosomal large subunit biogenesis (GO:0042273)2.46844847
117DNA replication-independent nucleosome organization (GO:0034724)2.46522265
118DNA replication-independent nucleosome assembly (GO:0006336)2.46522265
119cholesterol biosynthetic process (GO:0006695)2.46511560
120protein localization to kinetochore (GO:0034501)2.45555376
121metaphase plate congression (GO:0051310)2.45438907
122termination of RNA polymerase I transcription (GO:0006363)2.44808435
123maturation of 5.8S rRNA (GO:0000460)2.43960893
124establishment of chromosome localization (GO:0051303)2.43899549
125viral mRNA export from host cell nucleus (GO:0046784)2.43861989
126regulation of ligase activity (GO:0051340)2.43824653
127rRNA processing (GO:0006364)2.43460565
128mitotic recombination (GO:0006312)2.43259125
129mitotic chromosome condensation (GO:0007076)2.43217199
130positive regulation of cell cycle arrest (GO:0071158)2.43059646
131exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.42616747
132establishment of protein localization to endoplasmic reticulum (GO:0072599)2.42498908
133nucleotide-excision repair, DNA gap filling (GO:0006297)2.41352967
134DNA-templated transcription, elongation (GO:0006354)2.40850462
135proteasome assembly (GO:0043248)2.39735200
136G1/S transition of mitotic cell cycle (GO:0000082)2.39324589
137cell cycle G1/S phase transition (GO:0044843)2.39324589
138substantia nigra development (GO:0021762)2.39047056

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.58943474
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.10894936
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.91328884
4* EST1_17652178_ChIP-ChIP_JURKAT_Human3.88940311
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.78225282
6* GABP_17652178_ChIP-ChIP_JURKAT_Human3.49425791
7CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.29668863
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.07805516
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.06372334
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.84057494
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.83028372
12ELK1_19687146_ChIP-ChIP_HELA_Human2.76915451
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.73205317
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.68855135
15* ETS1_20019798_ChIP-Seq_JURKAT_Human2.61786940
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.52595185
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.45842986
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.39808335
19VDR_23849224_ChIP-Seq_CD4+_Human2.39205084
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.33066737
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.15899905
22BP1_19119308_ChIP-ChIP_Hs578T_Human2.12565178
23FUS_26573619_Chip-Seq_HEK293_Human2.09231329
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.05192354
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.04934273
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.01474219
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.98088777
28FOXM1_23109430_ChIP-Seq_U2OS_Human1.95542202
29* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.92394626
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.88296341
31NELFA_20434984_ChIP-Seq_ESCs_Mouse1.87979409
32HOXB4_20404135_ChIP-ChIP_EML_Mouse1.87059081
33FOXP3_21729870_ChIP-Seq_TREG_Human1.78706091
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.78000292
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.77432969
36* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.76412060
37* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75587104
38IRF8_21731497_ChIP-ChIP_J774_Mouse1.71957009
39MYC_18358816_ChIP-ChIP_MESCs_Mouse1.71430182
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67529065
41* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.65956315
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.65105184
43XRN2_22483619_ChIP-Seq_HELA_Human1.63750982
44AR_21909140_ChIP-Seq_LNCAP_Human1.62989958
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.61152422
46DCP1A_22483619_ChIP-Seq_HELA_Human1.59541686
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56998187
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.55242843
49EWS_26573619_Chip-Seq_HEK293_Human1.55122719
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.51381479
51WT1_19549856_ChIP-ChIP_CCG9911_Human1.45135448
52VDR_22108803_ChIP-Seq_LS180_Human1.45034086
53TTF2_22483619_ChIP-Seq_HELA_Human1.44865419
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44271743
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43912262
56IRF1_19129219_ChIP-ChIP_H3396_Human1.42635681
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.38849453
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37244083
59ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.31587365
60TAF15_26573619_Chip-Seq_HEK293_Human1.30222688
61MYC_18940864_ChIP-ChIP_HL60_Human1.29761668
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26345054
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26189939
64* SOX17_20123909_ChIP-Seq_XEN_Mouse1.22587156
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22226596
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.21772948
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21771609
68NANOG_18555785_ChIP-Seq_MESCs_Mouse1.18758071
69* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18118187
70DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.15238963
71MYCN_18555785_ChIP-Seq_MESCs_Mouse1.15209957
72STAT4_19710469_ChIP-ChIP_TH1__Mouse1.15157607
73PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13664205
74SOX2_16153702_ChIP-ChIP_HESCs_Human1.12087381
75ELK1_22589737_ChIP-Seq_MCF10A_Human1.11764097
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10268161
77GABP_19822575_ChIP-Seq_HepG2_Human1.09621564
78SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09122023
79POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08290954
80E2F1_21310950_ChIP-Seq_MCF-7_Human1.07973390
81BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06317284
82HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06210928
83SALL1_21062744_ChIP-ChIP_HESCs_Human1.05092634
84CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04333073
85* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.03116353
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02901242
87ER_23166858_ChIP-Seq_MCF-7_Human1.01382350
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00676154
89SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98703732
90ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97810476
91* YY1_21170310_ChIP-Seq_MESCs_Mouse0.97457484
92RBPJ_22232070_ChIP-Seq_NCS_Mouse0.95479624
93SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95189145
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94605468
95ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93522292
96RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.88779612
97KDM5A_27292631_Chip-Seq_BREAST_Human0.87835079
98SALL4_22934838_ChIP-ChIP_CD34+_Human0.85046125
99TP63_19390658_ChIP-ChIP_HaCaT_Human0.85030570
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83432898
101CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.83194343
102FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.82700821
103SPI1_23547873_ChIP-Seq_NB4_Human0.81885820
104ELF5_23300383_ChIP-Seq_T47D_Human0.79961304
105GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.78968721
106CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.78304668
107SOX9_26525672_Chip-Seq_HEART_Mouse0.76375330
108TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.76165996
109ZNF274_21170338_ChIP-Seq_K562_Hela0.76095961
110NANOG_16153702_ChIP-ChIP_HESCs_Human0.75540835
111CIITA_25753668_ChIP-Seq_RAJI_Human0.75161945
112FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.75018027
113STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.74685043
114FLI1_27457419_Chip-Seq_LIVER_Mouse0.74605073
115TFEB_21752829_ChIP-Seq_HELA_Human0.74187818
116CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.74120374
117FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64497416
118CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.62839567
119KLF4_18555785_ChIP-Seq_MESCs_Mouse0.60915931

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.98382635
2MP0003806_abnormal_nucleotide_metabolis3.11817504
3MP0008877_abnormal_DNA_methylation2.93150753
4MP0001529_abnormal_vocalization2.86816411
5MP0005171_absent_coat_pigmentation2.72554467
6MP0003136_yellow_coat_color2.65154029
7MP0010094_abnormal_chromosome_stability2.56436359
8MP0000920_abnormal_myelination2.51869885
9MP0004957_abnormal_blastocyst_morpholog2.38940742
10MP0003077_abnormal_cell_cycle2.32999517
11MP0009697_abnormal_copulation2.31434492
12MP0003186_abnormal_redox_activity2.31425220
13MP0008058_abnormal_DNA_repair2.28934364
14MP0003950_abnormal_plasma_membrane2.11653169
15MP0001905_abnormal_dopamine_level2.05667067
16MP0003880_abnormal_central_pattern1.95666684
17MP0005671_abnormal_response_to1.90461154
18MP0003693_abnormal_embryo_hatching1.90036557
19MP0002163_abnormal_gland_morphology1.85115478
20MP0004134_abnormal_chest_morphology1.84146188
21MP0001293_anophthalmia1.84032254
22MP0008932_abnormal_embryonic_tissue1.80822654
23MP0008007_abnormal_cellular_replicative1.75156855
24MP0006036_abnormal_mitochondrial_physio1.72977262
25MP0006035_abnormal_mitochondrial_morpho1.67548564
26MP0001485_abnormal_pinna_reflex1.67192711
27MP0003111_abnormal_nucleus_morphology1.61817558
28MP0000372_irregular_coat_pigmentation1.60319161
29MP0001835_abnormal_antigen_presentation1.55448558
30MP0004147_increased_porphyrin_level1.54571560
31MP0005408_hypopigmentation1.50891359
32MP0002938_white_spotting1.50157842
33MP0005084_abnormal_gallbladder_morpholo1.42169401
34MP0003787_abnormal_imprinting1.39638733
35MP0005623_abnormal_meninges_morphology1.38892010
36MP0005075_abnormal_melanosome_morpholog1.37831690
37MP0002148_abnormal_hypersensitivity_rea1.37573945
38MP0002396_abnormal_hematopoietic_system1.32267960
39MP0004742_abnormal_vestibular_system1.32212253
40MP0002009_preneoplasia1.32002262
41MP0003890_abnormal_embryonic-extraembry1.30689883
42MP0003121_genomic_imprinting1.29748563
43MP0002019_abnormal_tumor_incidence1.27567648
44MP0009333_abnormal_splenocyte_physiolog1.26995095
45MP0001672_abnormal_embryogenesis/_devel1.26902269
46MP0005380_embryogenesis_phenotype1.26902269
47MP0002080_prenatal_lethality1.24767333
48MP0000358_abnormal_cell_content/1.24086109
49MP0009379_abnormal_foot_pigmentation1.23509695
50MP0001730_embryonic_growth_arrest1.23336421
51MP0008995_early_reproductive_senescence1.21544422
52MP0006072_abnormal_retinal_apoptosis1.21318157
53MP0001145_abnormal_male_reproductive1.19912059
54MP0009785_altered_susceptibility_to1.18339662
55MP0003718_maternal_effect1.17760246
56MP0003937_abnormal_limbs/digits/tail_de1.17370463
57MP0008789_abnormal_olfactory_epithelium1.17259692
58MP0005000_abnormal_immune_tolerance1.16078994
59MP0003315_abnormal_perineum_morphology1.15601308
60MP0002095_abnormal_skin_pigmentation1.15290698
61MP0000350_abnormal_cell_proliferation1.14559752
62MP0003763_abnormal_thymus_physiology1.14414834
63MP0000653_abnormal_sex_gland1.13852293
64MP0005310_abnormal_salivary_gland1.12351283
65MP0000490_abnormal_crypts_of1.12209010
66MP0003984_embryonic_growth_retardation1.08876934
67MP0003567_abnormal_fetal_cardiomyocyte1.08163348
68MP0002088_abnormal_embryonic_growth/wei1.06869824
69MP0002085_abnormal_embryonic_tissue1.06756505
70MP0001119_abnormal_female_reproductive1.05891532
71MP0003786_premature_aging1.05581552
72MP0001800_abnormal_humoral_immune1.04707143
73MP0002084_abnormal_developmental_patter1.04652956
74MP0005551_abnormal_eye_electrophysiolog1.04124193
75MP0005253_abnormal_eye_physiology1.03891508
76MP0003634_abnormal_glial_cell1.03484755
77MP0003123_paternal_imprinting1.00608106
78MP0001346_abnormal_lacrimal_gland0.99985073
79MP0002420_abnormal_adaptive_immunity0.99017452
80MP0006292_abnormal_olfactory_placode0.98314559
81MP0002452_abnormal_antigen_presenting0.97996219
82MP0001853_heart_inflammation0.96050612
83MP0002166_altered_tumor_susceptibility0.95885512
84MP0001727_abnormal_embryo_implantation0.95829998
85MP0001819_abnormal_immune_cell0.95587079
86MP0001963_abnormal_hearing_physiology0.95255244
87MP0000703_abnormal_thymus_morphology0.93503463
88MP0005410_abnormal_fertilization0.93093008
89MP0006082_CNS_inflammation0.92791054
90MP0003632_abnormal_nervous_system0.92059406
91MP0002723_abnormal_immune_serum0.91939686
92MP0001286_abnormal_eye_development0.90953516
93MP0010307_abnormal_tumor_latency0.90858682
94MP0002398_abnormal_bone_marrow0.90374037
95MP0003941_abnormal_skin_development0.90108390
96MP0004885_abnormal_endolymph0.89066522
97MP0000383_abnormal_hair_follicle0.87907746
98MP0000778_abnormal_nervous_system0.87742076
99MP0005379_endocrine/exocrine_gland_phen0.86912456
100MP0003221_abnormal_cardiomyocyte_apopto0.85664693
101MP0001986_abnormal_taste_sensitivity0.85589984
102MP0006054_spinal_hemorrhage0.84680579
103MP0000716_abnormal_immune_system0.83550297
104MP0002006_tumorigenesis0.82809039
105MP0002277_abnormal_respiratory_mucosa0.82421955
106MP0000647_abnormal_sebaceous_gland0.81603865
107MP0002722_abnormal_immune_system0.79850206
108MP0000689_abnormal_spleen_morphology0.79214504
109MP0005195_abnormal_posterior_eye0.79058351
110MP0005409_darkened_coat_color0.78837843
111MP0003698_abnormal_male_reproductive0.78118148
112MP0004808_abnormal_hematopoietic_stem0.78088046
113MP0002272_abnormal_nervous_system0.77063599
114MP0002160_abnormal_reproductive_system0.76346624
115MP0002751_abnormal_autonomic_nervous0.75944300
116MP0001764_abnormal_homeostasis0.75005954
117MP0008260_abnormal_autophagy0.74962684
118MP0000465_gastrointestinal_hemorrhage0.74546116
119MP0002233_abnormal_nose_morphology0.74227332
120MP0010352_gastrointestinal_tract_polyps0.74067142
121MP0003690_abnormal_glial_cell0.73909205
122MP0001929_abnormal_gametogenesis0.73475664
123MP0000685_abnormal_immune_system0.72992731
124MP0002429_abnormal_blood_cell0.72962353
125MP0005389_reproductive_system_phenotype0.72776911
126MP0008873_increased_physiological_sensi0.72750592
127MP0002210_abnormal_sex_determination0.71709097
128MP0000762_abnormal_tongue_morphology0.71289243
129MP0001697_abnormal_embryo_size0.71182431
130MP0010678_abnormal_skin_adnexa0.70132512
131MP0005025_abnormal_response_to0.69930901
132MP0003656_abnormal_erythrocyte_physiolo0.69609967
133MP0005387_immune_system_phenotype0.69531874
134MP0001790_abnormal_immune_system0.69531874
135MP0005395_other_phenotype0.69205646
136MP0002877_abnormal_melanocyte_morpholog0.68312499
137MP0010030_abnormal_orbit_morphology0.68107692
138MP0002234_abnormal_pharynx_morphology0.67434795
139MP0005499_abnormal_olfactory_system0.67326561
140MP0005394_taste/olfaction_phenotype0.67326561
141MP0003699_abnormal_female_reproductive0.67159342
142MP0002132_abnormal_respiratory_system0.66360650
143MP0004197_abnormal_fetal_growth/weight/0.66140437
144MP0005391_vision/eye_phenotype0.64777038
145MP0000313_abnormal_cell_death0.64090304
146MP0001919_abnormal_reproductive_system0.63871592
147MP0005501_abnormal_skin_physiology0.63633898
148MP0001243_abnormal_dermal_layer0.63476113
149MP0002697_abnormal_eye_size0.62864121
150MP0002102_abnormal_ear_morphology0.62140634
151MP0000631_abnormal_neuroendocrine_gland0.61664897
152MP0002161_abnormal_fertility/fecundity0.61164654
153MP0003448_altered_tumor_morphology0.60736593

Predicted human phenotypes

RankGene SetZ-score
1Increased serum pyruvate (HP:0003542)4.31698210
2Abnormality of glycolysis (HP:0004366)4.31698210
3Parakeratosis (HP:0001036)4.07471521
4Cerebral hypomyelination (HP:0006808)3.79586910
5Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.68222301
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.59050945
7Chromsome breakage (HP:0040012)3.55508736
8Acute necrotizing encephalopathy (HP:0006965)3.53693406
9Meckel diverticulum (HP:0002245)3.28717067
10Hepatic necrosis (HP:0002605)3.28542469
11Degeneration of the lateral corticospinal tracts (HP:0002314)3.19643734
12Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.19643734
13Abnormality of the ileum (HP:0001549)3.18876818
14Birth length less than 3rd percentile (HP:0003561)3.17513388
15Abnormality of the preputium (HP:0100587)3.12211552
16Abnormality of chromosome stability (HP:0003220)3.10632066
17Aplastic anemia (HP:0001915)3.09536327
18Increased intramyocellular lipid droplets (HP:0012240)3.01272875
19Hypoplastic pelvis (HP:0008839)2.99968532
20Progressive macrocephaly (HP:0004481)2.96603681
21Aplasia/Hypoplasia of the uvula (HP:0010293)2.93904158
22Decreased activity of mitochondrial respiratory chain (HP:0008972)2.92570513
23Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.92570513
24Leukodystrophy (HP:0002415)2.92523123
25Abnormal mitochondria in muscle tissue (HP:0008316)2.87680928
26Cerebral edema (HP:0002181)2.83139365
27Mitochondrial inheritance (HP:0001427)2.82786150
28Type I transferrin isoform profile (HP:0003642)2.81428577
29Microvesicular hepatic steatosis (HP:0001414)2.75805546
30Abnormality of the anterior horn cell (HP:0006802)2.72435860
31Degeneration of anterior horn cells (HP:0002398)2.72435860
32Congenital ichthyosiform erythroderma (HP:0007431)2.65480863
33Myelodysplasia (HP:0002863)2.64437346
34Agnosia (HP:0010524)2.63614780
35Increased serum lactate (HP:0002151)2.63226364
36Increased hepatocellular lipid droplets (HP:0006565)2.62124247
37Renal Fanconi syndrome (HP:0001994)2.61244579
38Patchy hypopigmentation of hair (HP:0011365)2.60829595
39Pancytopenia (HP:0001876)2.57170336
40White forelock (HP:0002211)2.54423310
41Duodenal stenosis (HP:0100867)2.50648365
42Small intestinal stenosis (HP:0012848)2.50648365
43Abnormality of cells of the erythroid lineage (HP:0012130)2.45367459
44Adrenal hypoplasia (HP:0000835)2.44169928
45Lactic acidosis (HP:0003128)2.43647430
46Hypoplasia of the capital femoral epiphysis (HP:0003090)2.39357074
47Small epiphyses (HP:0010585)2.38774244
48Horseshoe kidney (HP:0000085)2.38533021
49Acute encephalopathy (HP:0006846)2.37018979
50Abnormality of methionine metabolism (HP:0010901)2.35793737
51CNS hypomyelination (HP:0003429)2.34810864
52Abnormal hair whorl (HP:0010721)2.34651188
53Increased CSF lactate (HP:0002490)2.33990609
54Sensory axonal neuropathy (HP:0003390)2.30682478
55Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.29971344
56Absent epiphyses (HP:0010577)2.29971344
57Combined immunodeficiency (HP:0005387)2.26987449
58Increased muscle lipid content (HP:0009058)2.24409596
59Multiple enchondromatosis (HP:0005701)2.22044650
60Reticulocytopenia (HP:0001896)2.19924655
61Asplenia (HP:0001746)2.19886104
62Septo-optic dysplasia (HP:0100842)2.19783557
63Respiratory failure (HP:0002878)2.17890695
64Abnormality of renal resorption (HP:0011038)2.17284246
65Stenosis of the external auditory canal (HP:0000402)2.16542715
66Abnormal protein N-linked glycosylation (HP:0012347)2.15473822
67Abnormal protein glycosylation (HP:0012346)2.15473822
68Abnormal glycosylation (HP:0012345)2.15473822
69Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.15473822
70Oral leukoplakia (HP:0002745)2.15329177
71Autoamputation (HP:0001218)2.13512383
72Abnormality of the duodenum (HP:0002246)2.12401953
73Sloping forehead (HP:0000340)2.12211177
74Abnormal number of erythroid precursors (HP:0012131)2.11975490
75Absent thumb (HP:0009777)2.11469756
76Morphological abnormality of the inner ear (HP:0011390)2.11144201
77Abnormal lung lobation (HP:0002101)2.11033935
78Septate vagina (HP:0001153)2.08763029
79Abnormal auditory evoked potentials (HP:0006958)2.04763551
80Abnormality of aspartate family amino acid metabolism (HP:0010899)2.04749462
81Irregular epiphyses (HP:0010582)2.04287006
82Neoplasm of the colon (HP:0100273)2.03877786
83Cupped ear (HP:0000378)2.00416934
84Respiratory difficulties (HP:0002880)1.99773236
85Pallor (HP:0000980)1.99359505
86Esophageal atresia (HP:0002032)1.98929004
87Aplasia/Hypoplasia of the spleen (HP:0010451)1.98546064
88Nephroblastoma (Wilms tumor) (HP:0002667)1.97890038
89Pancreatic cysts (HP:0001737)1.97370382
90Hepatocellular necrosis (HP:0001404)1.96958992
91Lipid accumulation in hepatocytes (HP:0006561)1.96735274
92Medial flaring of the eyebrow (HP:0010747)1.96628295
93Neoplasm of the adrenal gland (HP:0100631)1.96390954
94Triphalangeal thumb (HP:0001199)1.96307138
95Methylmalonic acidemia (HP:0002912)1.94296292
96Aplasia/Hypoplasia of the sacrum (HP:0008517)1.93152280
97Abnormality of midbrain morphology (HP:0002418)1.92059922
98Molar tooth sign on MRI (HP:0002419)1.92059922
99Squamous cell carcinoma (HP:0002860)1.91220657
100IgM deficiency (HP:0002850)1.90992698
101Abnormality of the septum pellucidum (HP:0007375)1.89110673
102Abnormality of T cell number (HP:0011839)1.88912403
103Neurofibrillary tangles (HP:0002185)1.88662079
1043-Methylglutaconic aciduria (HP:0003535)1.87373152
105Abnormality of the labia minora (HP:0012880)1.85332569
106Breast hypoplasia (HP:0003187)1.85118580
107Absent septum pellucidum (HP:0001331)1.84302091
108Embryonal renal neoplasm (HP:0011794)1.84165276
109Sparse eyelashes (HP:0000653)1.83455640
110T lymphocytopenia (HP:0005403)1.82055640
111Volvulus (HP:0002580)1.81747014
112Abnormal spermatogenesis (HP:0008669)1.81663283
113Bifid tongue (HP:0010297)1.80898400
114Heterochromia iridis (HP:0001100)1.80857031
115IgG deficiency (HP:0004315)1.80582410
116Glossoptosis (HP:0000162)1.80541829
117Generalized aminoaciduria (HP:0002909)1.78983247
118Congenital primary aphakia (HP:0007707)1.77387333
119Increased nuchal translucency (HP:0010880)1.76735080
120Lethargy (HP:0001254)1.75590029
121Nephrogenic diabetes insipidus (HP:0009806)1.75251240
122Cutaneous melanoma (HP:0012056)1.75089256
123Duplicated collecting system (HP:0000081)1.75060632
124Cleft eyelid (HP:0000625)1.74739076
125Macrocytic anemia (HP:0001972)1.74395111
126Abnormality of DNA repair (HP:0003254)1.73561020
127Cellular immunodeficiency (HP:0005374)1.72962896
128Absent radius (HP:0003974)1.72752612
129Secondary amenorrhea (HP:0000869)1.72477428
130Postnatal microcephaly (HP:0005484)1.71580113
131Severe combined immunodeficiency (HP:0004430)1.71348875
132Rhabdomyosarcoma (HP:0002859)1.71094899
133Bone marrow hypocellularity (HP:0005528)1.70913125
134Exercise intolerance (HP:0003546)1.70703671
135Optic disc pallor (HP:0000543)1.69048337
136Abnormality of placental membranes (HP:0011409)1.68281737
137Amniotic constriction ring (HP:0009775)1.68281737
138Gait imbalance (HP:0002141)1.67722382
139Abnormality of incisor morphology (HP:0011063)1.65753386
140Decreased lacrimation (HP:0000633)1.64920547
141Peripheral hypomyelination (HP:0007182)1.64673250
142Alacrima (HP:0000522)1.63299267
143Vaginal atresia (HP:0000148)1.63175968
144Genital tract atresia (HP:0001827)1.62237428
145Long clavicles (HP:0000890)1.61554155
14611 pairs of ribs (HP:0000878)1.61301787
147Amaurosis fugax (HP:0100576)1.61255539
148Aplasia involving forearm bones (HP:0009822)1.61237535
149Absent forearm bone (HP:0003953)1.61237535
150Exertional dyspnea (HP:0002875)1.60267965
151Patellar aplasia (HP:0006443)1.59818078
152Abnormality of the fetal cardiovascular system (HP:0010948)1.59801791
153Abnormal umbilical cord blood vessels (HP:0011403)1.59801791
154Single umbilical artery (HP:0001195)1.59801791
155Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.59466222
156Supernumerary spleens (HP:0009799)1.57944543
157Abnormality of the renal collecting system (HP:0004742)1.57660912
158Gastrointestinal atresia (HP:0002589)1.54429082
159Abnormality of the corticospinal tract (HP:0002492)1.53614675
160Abnormal autonomic nervous system physiology (HP:0012332)1.53231634
161Abnormality of the phalanges of the 2nd finger (HP:0009541)1.52406763
162Increased IgM level (HP:0003496)1.52218646
163Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.52074321
164Rectovaginal fistula (HP:0000143)1.51422452
165Rectal fistula (HP:0100590)1.51422452
166Anteriorly placed anus (HP:0001545)1.51374578
167Colon cancer (HP:0003003)1.51188080

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK4.60366612
2VRK23.46746041
3BUB13.34997310
4MST43.12838811
5STK393.04147892
6TSSK62.61639628
7NEK12.54263644
8OXSR12.35758726
9EIF2AK12.28211889
10BCR2.22181389
11SRPK12.20550084
12PNCK2.14100786
13MKNK12.08883174
14CDC72.06324822
15WEE12.04236334
16TRIM282.03402199
17EIF2AK32.02280040
18CASK1.97714842
19BMPR21.85986785
20VRK11.73837923
21STK161.65444843
22PLK21.63828004
23PLK31.59241021
24CCNB11.50668373
25PLK41.50397040
26NME21.39908439
27NEK21.35492174
28PASK1.30870515
29PKN11.28700316
30NME11.26143795
31EPHB11.22037124
32ACVR1B1.21483071
33MAP4K21.19329166
34BRSK21.18772688
35CLK11.18430427
36FGR1.18171760
37MAPKAPK51.15509533
38TAF11.14958854
39TXK1.13652536
40TESK21.12551761
41TRPM71.12433856
42STK101.10002955
43CDK191.07205983
44LIMK11.06523917
45STK41.00717359
46PDK21.00534623
47SCYL20.99882946
48BMPR1B0.98796672
49TNIK0.97872297
50RIPK40.97761243
51GRK70.97408374
52BCKDK0.95922135
53RPS6KB20.93732424
54PIK3CA0.88882053
55EIF2AK20.85240893
56KDR0.84853620
57ROCK20.84285261
58RPS6KA40.83943908
59MELK0.83090871
60TLK10.79535255
61NEK60.79395672
62BRD40.77374299
63MAP3K140.75053479
64AURKB0.74414381
65WNK40.73710929
66CHEK10.73070039
67ADRBK20.70345318
68LCK0.70201854
69STK30.69600816
70ERBB30.69540747
71PLK10.68652004
72TTK0.68358992
73ATR0.67859891
74ITK0.67849059
75IRAK40.66185771
76CDK70.65985793
77YES10.65629983
78IKBKB0.64787047
79WNK30.64780486
80FES0.63832284
81MKNK20.63326049
82CDK80.63050449
83RPS6KA50.62006930
84CSNK1G30.61866435
85CAMK2B0.61396341
86LYN0.61367342
87CSNK2A20.59514533
88STK240.57634017
89DYRK30.56909779
90MAP3K120.53709168
91NUAK10.53346259
92ATM0.52939203
93MET0.52450127
94MARK30.52361497
95CDK30.52007275
96CSNK2A10.51312053
97PAK10.50591051
98TGFBR10.49962816
99SIK30.49727514
100PRKCQ0.49720913
101DYRK20.49099653
102AURKA0.48308588
103ZAK0.47794771
104BRSK10.46805634
105GRK60.46080921
106BTK0.44081110
107CSF1R0.43989847
108CDK140.43664770
109ALK0.42523301
110ILK0.42470606
111CDK180.41886608
112CSNK1E0.41884519
113* CDK10.41411023
114CDK40.41305390
115CDK150.40623042
116TESK10.40384629
117PIM10.40262003
118TEC0.39819989
119UHMK10.39433545
120PRKCI0.39310712
121* CDK20.39271866
122CDK11A0.39128124
123CHEK20.38922030
124TAOK30.37876448
125CSNK1G10.36798192
126BRAF0.36602986
127LRRK20.36427194
128CAMK2D0.35210960
129CSNK1A1L0.35198107
130PAK40.34833560
131DAPK10.34616339
132INSR0.34574386
133CDK90.33453501
134CDK60.31645907
135MAP2K70.31594721
136STK38L0.28584026
137MAP3K80.26626491
138FGFR10.25710131
139MAP3K40.25264659

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.45019192
2RNA polymerase_Homo sapiens_hsa030203.05302784
3Mismatch repair_Homo sapiens_hsa034302.80243679
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.77693175
5Ribosome_Homo sapiens_hsa030102.73803061
6* Spliceosome_Homo sapiens_hsa030402.53676573
7Protein export_Homo sapiens_hsa030602.47922964
8Oxidative phosphorylation_Homo sapiens_hsa001902.43385638
9DNA replication_Homo sapiens_hsa030302.40940336
10Non-homologous end-joining_Homo sapiens_hsa034502.38293064
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.36155839
12Nucleotide excision repair_Homo sapiens_hsa034202.14430991
13Basal transcription factors_Homo sapiens_hsa030221.98699418
14Parkinsons disease_Homo sapiens_hsa050121.97711971
15Homologous recombination_Homo sapiens_hsa034401.93060299
16RNA transport_Homo sapiens_hsa030131.91693035
17Graft-versus-host disease_Homo sapiens_hsa053321.90686921
18RNA degradation_Homo sapiens_hsa030181.80289429
19Allograft rejection_Homo sapiens_hsa053301.75697231
20Steroid biosynthesis_Homo sapiens_hsa001001.71669045
21Cell cycle_Homo sapiens_hsa041101.58308987
22Huntingtons disease_Homo sapiens_hsa050161.54528014
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.54363341
24Base excision repair_Homo sapiens_hsa034101.52923763
25Alzheimers disease_Homo sapiens_hsa050101.50354849
26Ether lipid metabolism_Homo sapiens_hsa005651.48701996
27Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.38404990
28Pyrimidine metabolism_Homo sapiens_hsa002401.35487055
29Antigen processing and presentation_Homo sapiens_hsa046121.33007488
30Rheumatoid arthritis_Homo sapiens_hsa053231.29319287
31Fanconi anemia pathway_Homo sapiens_hsa034601.26772601
32Primary immunodeficiency_Homo sapiens_hsa053401.26248837
33Folate biosynthesis_Homo sapiens_hsa007901.24833340
34Autoimmune thyroid disease_Homo sapiens_hsa053201.24646486
35* Epstein-Barr virus infection_Homo sapiens_hsa051691.21928110
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.17411303
37Propanoate metabolism_Homo sapiens_hsa006401.15304301
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.12072297
39Systemic lupus erythematosus_Homo sapiens_hsa053221.10990608
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04880510
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.03829346
42Selenocompound metabolism_Homo sapiens_hsa004501.03738162
43Type I diabetes mellitus_Homo sapiens_hsa049401.02914115
44Purine metabolism_Homo sapiens_hsa002301.02584520
45mRNA surveillance pathway_Homo sapiens_hsa030150.98740245
46Fatty acid elongation_Homo sapiens_hsa000620.97277187
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97079659
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.96127232
49Sphingolipid metabolism_Homo sapiens_hsa006000.93474830
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.93177517
51Collecting duct acid secretion_Homo sapiens_hsa049660.91779243
52Phototransduction_Homo sapiens_hsa047440.90506923
53Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.88044739
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85218506
55Biosynthesis of amino acids_Homo sapiens_hsa012300.83012998
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82952463
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81535913
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81342036
59Carbon metabolism_Homo sapiens_hsa012000.80903396
60Measles_Homo sapiens_hsa051620.80477257
61Pyruvate metabolism_Homo sapiens_hsa006200.76034852
62T cell receptor signaling pathway_Homo sapiens_hsa046600.75292443
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75204278
64Legionellosis_Homo sapiens_hsa051340.73295881
65* Viral carcinogenesis_Homo sapiens_hsa052030.72924702
66One carbon pool by folate_Homo sapiens_hsa006700.70454956
67Vibrio cholerae infection_Homo sapiens_hsa051100.68897419
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68782541
69Phagosome_Homo sapiens_hsa041450.65616385
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.64918550
71African trypanosomiasis_Homo sapiens_hsa051430.64547544
72NF-kappa B signaling pathway_Homo sapiens_hsa040640.63908526
73Herpes simplex infection_Homo sapiens_hsa051680.63404328
74Malaria_Homo sapiens_hsa051440.61359817
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60628759
76p53 signaling pathway_Homo sapiens_hsa041150.59835003
77Hematopoietic cell lineage_Homo sapiens_hsa046400.59436378
78Linoleic acid metabolism_Homo sapiens_hsa005910.59058717
79Arachidonic acid metabolism_Homo sapiens_hsa005900.58465962
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57786897
81Regulation of autophagy_Homo sapiens_hsa041400.56548550
82Asthma_Homo sapiens_hsa053100.54426317
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53957991
84Oocyte meiosis_Homo sapiens_hsa041140.53395479
85Shigellosis_Homo sapiens_hsa051310.53040373
86Salmonella infection_Homo sapiens_hsa051320.52487346
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51605789
88Metabolic pathways_Homo sapiens_hsa011000.50491232
89Pentose phosphate pathway_Homo sapiens_hsa000300.49511236
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49469074
91Alcoholism_Homo sapiens_hsa050340.48655173
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48044526
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46486714
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42221580
95Viral myocarditis_Homo sapiens_hsa054160.41869810
96Peroxisome_Homo sapiens_hsa041460.41067182
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40859166
98Tight junction_Homo sapiens_hsa045300.40339430
99Leishmaniasis_Homo sapiens_hsa051400.40018078
100Serotonergic synapse_Homo sapiens_hsa047260.38858281
101Vitamin B6 metabolism_Homo sapiens_hsa007500.37762597
102Other glycan degradation_Homo sapiens_hsa005110.32548219
103N-Glycan biosynthesis_Homo sapiens_hsa005100.32503679
104HTLV-I infection_Homo sapiens_hsa051660.32336289
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.31747593
106Pertussis_Homo sapiens_hsa051330.31644081
107Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31566883
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29013567
109Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28689831
110Renal cell carcinoma_Homo sapiens_hsa052110.28072971
111Axon guidance_Homo sapiens_hsa043600.27865587
112TGF-beta signaling pathway_Homo sapiens_hsa043500.27401881
113Butanoate metabolism_Homo sapiens_hsa006500.26972551
114Glutathione metabolism_Homo sapiens_hsa004800.26912444
115Cardiac muscle contraction_Homo sapiens_hsa042600.26679481
116MicroRNAs in cancer_Homo sapiens_hsa052060.26551473
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26178354
118Fatty acid metabolism_Homo sapiens_hsa012120.23538274
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23224595
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.23160577
121Chemokine signaling pathway_Homo sapiens_hsa040620.21535797
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.21276483
123Apoptosis_Homo sapiens_hsa042100.21217377
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.21109964
125Hepatitis B_Homo sapiens_hsa051610.20997740
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19516206
127RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.17785703
128Sulfur metabolism_Homo sapiens_hsa009200.17134803
129Caffeine metabolism_Homo sapiens_hsa002320.14740393
130Thyroid cancer_Homo sapiens_hsa052160.11187915
131Pentose and glucuronate interconversions_Homo sapiens_hsa000400.08190630
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.07654820
133Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.07353211
134Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.05809794
135Wnt signaling pathway_Homo sapiens_hsa043100.02144964
136Sulfur relay system_Homo sapiens_hsa041220.01950833

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