SNX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1interferon-gamma secretion (GO:0072643)5.36141301
2negative regulation of erythrocyte differentiation (GO:0045647)4.26246332
3Arp2/3 complex-mediated actin nucleation (GO:0034314)4.05903752
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.95730481
5negative regulation of cell killing (GO:0031342)3.95730481
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.62531791
7antigen processing and presentation via MHC class Ib (GO:0002475)3.55209622
8regulation of gamma-delta T cell activation (GO:0046643)3.51812990
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.50396860
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.50396860
11detection of other organism (GO:0098543)3.46014068
12antigen processing and presentation of endogenous antigen (GO:0019883)3.42479019
13Golgi transport vesicle coating (GO:0048200)3.41090639
14COPI coating of Golgi vesicle (GO:0048205)3.41090639
15detection of bacterium (GO:0016045)3.36586136
16cellular response to interferon-alpha (GO:0035457)3.35329475
17formation of translation preinitiation complex (GO:0001731)3.31027278
18antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.22202403
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.17843707
20detection of external biotic stimulus (GO:0098581)3.13616340
21regulation of histone H3-K27 methylation (GO:0061085)3.07753090
22detection of molecule of bacterial origin (GO:0032490)3.01996091
23immunoglobulin mediated immune response (GO:0016064)3.01606866
24macrophage activation involved in immune response (GO:0002281)2.99895458
25positive thymic T cell selection (GO:0045059)2.98351780
26proteasome assembly (GO:0043248)2.97276512
27actin nucleation (GO:0045010)2.95103010
28positive regulation by symbiont of host defense response (GO:0052509)2.95086281
29modulation by symbiont of host defense response (GO:0052031)2.95086281
30modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.95086281
31modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.95086281
32positive regulation by organism of defense response of other organism involved in symbiotic interact2.95086281
33modulation by symbiont of host immune response (GO:0052553)2.95086281
34positive regulation of gamma-delta T cell activation (GO:0046645)2.93609779
35glycosphingolipid catabolic process (GO:0046479)2.90597125
36positive regulation of cellular amide metabolic process (GO:0034250)2.90167483
37regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.90022089
38anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.89938306
39positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.88287262
40negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.87831372
41regulation of interferon-beta biosynthetic process (GO:0045357)2.86798784
42negative thymic T cell selection (GO:0045060)2.86560443
43ribosomal small subunit assembly (GO:0000028)2.82482418
44negative T cell selection (GO:0043383)2.79889267
45positive regulation of lamellipodium assembly (GO:0010592)2.79793410
46hepatocyte apoptotic process (GO:0097284)2.79023972
47B cell receptor signaling pathway (GO:0050853)2.76974940
48cellular extravasation (GO:0045123)2.76639072
49regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.76636549
50neutrophil activation involved in immune response (GO:0002283)2.74254484
51pinocytosis (GO:0006907)2.73565614
52histone-serine phosphorylation (GO:0035404)2.72586580
53negative regulation of interleukin-12 production (GO:0032695)2.72427094
54thymic T cell selection (GO:0045061)2.71289422
55chaperone mediated protein folding requiring cofactor (GO:0051085)2.71074443
56amino sugar catabolic process (GO:0046348)2.70592396
57folic acid transport (GO:0015884)2.70005651
58germinal center formation (GO:0002467)2.69919332
59regulation of B cell receptor signaling pathway (GO:0050855)2.65421963
60negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.64743449
61negative regulation of ligase activity (GO:0051352)2.64743449
62B cell mediated immunity (GO:0019724)2.63414416
63detection of biotic stimulus (GO:0009595)2.62704559
64positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.62549226
65DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.62328358
66T cell selection (GO:0045058)2.62246690
67negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.59813958
68leukocyte aggregation (GO:0070486)2.58800710
69intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.58573989
70signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.58573989
71hypotonic response (GO:0006971)2.58538731
72signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.58518483
73signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.58518483
74signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.58518483
75response to type I interferon (GO:0034340)2.57987085
76regulation of cellular amino acid metabolic process (GO:0006521)2.57733204
77regulation of spindle organization (GO:0090224)2.57728151
78peptide catabolic process (GO:0043171)2.57490102
79glycolipid catabolic process (GO:0019377)2.57368100
80signal transduction involved in DNA integrity checkpoint (GO:0072401)2.57174950
81signal transduction involved in DNA damage checkpoint (GO:0072422)2.57174950
82regulation of dendritic cell antigen processing and presentation (GO:0002604)2.55328244
83positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.55103603
84pentose-phosphate shunt (GO:0006098)2.54897140
85positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.53469594
86protein localization to endosome (GO:0036010)2.53434685
87cellular response to type I interferon (GO:0071357)2.53020204
88type I interferon signaling pathway (GO:0060337)2.53020204
89regulation of extracellular matrix disassembly (GO:0010715)2.52532837
90response to laminar fluid shear stress (GO:0034616)2.52297389
91antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.51210400
92positive regulation of B cell differentiation (GO:0045579)2.51016628
93regulation of leukocyte degranulation (GO:0043300)2.50351502
94low-density lipoprotein particle clearance (GO:0034383)2.50340345
95signal transduction involved in cell cycle checkpoint (GO:0072395)2.49578118
96positive T cell selection (GO:0043368)2.49450795
97regulation of necroptotic process (GO:0060544)2.49283805
98cellular response to thyroid hormone stimulus (GO:0097067)2.49084214
99mitotic nuclear envelope disassembly (GO:0007077)2.48820690
100sequestering of actin monomers (GO:0042989)2.48505728
101purine nucleobase biosynthetic process (GO:0009113)2.48297457
102negative regulation of lymphocyte mediated immunity (GO:0002707)2.47773685
103positive regulation of extracellular matrix organization (GO:1903055)2.46959626
104response to muramyl dipeptide (GO:0032495)2.46738879
105DNA deamination (GO:0045006)2.46318300
106positive regulation of ligase activity (GO:0051351)2.45557532
107interferon-gamma-mediated signaling pathway (GO:0060333)2.45475022
108negative regulation of leukocyte mediated immunity (GO:0002704)2.44251704
109positive regulation of Rap GTPase activity (GO:0032854)2.42722109
110positive regulation of antigen processing and presentation (GO:0002579)2.42381552
111ribosome assembly (GO:0042255)2.42253025
112negative regulation of stress fiber assembly (GO:0051497)2.41503359
113regulation of T cell tolerance induction (GO:0002664)2.41168598
114regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.41097924
115regulation of mast cell degranulation (GO:0043304)2.40413635
116positive regulation of Cdc42 GTPase activity (GO:0043089)2.40059685
117positive regulation of T cell chemotaxis (GO:0010820)2.39908037
118regulation of T cell chemotaxis (GO:0010819)2.39908037
119JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.39199195
120regulation of myeloid leukocyte mediated immunity (GO:0002886)2.38742230
121lipopolysaccharide-mediated signaling pathway (GO:0031663)2.37947608
122positive regulation of lamellipodium organization (GO:1902745)2.37704281
123protein localization to kinetochore (GO:0034501)2.37159352
124surfactant homeostasis (GO:0043129)2.36880685
125negative regulation of granulocyte differentiation (GO:0030853)2.35534074
126response to interleukin-15 (GO:0070672)2.35415820
127barbed-end actin filament capping (GO:0051016)2.35265796
128regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.34775706
129protein localization to chromosome, centromeric region (GO:0071459)2.34608135
130response to host (GO:0075136)2.34439866
131response to host defenses (GO:0052200)2.34439866
132response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.34439866
133folic acid metabolic process (GO:0046655)2.34351388
134regulation of translational termination (GO:0006449)2.34269226
135natural killer cell mediated immunity (GO:0002228)2.33839820
136natural killer cell mediated cytotoxicity (GO:0042267)2.33839820
137positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.33679421
138regulation of gamma-delta T cell differentiation (GO:0045586)2.32424472
139regulation of macrophage cytokine production (GO:0010935)2.31287234
140nucleobase biosynthetic process (GO:0046112)2.30944379
141membrane disassembly (GO:0030397)2.30608255
142nuclear envelope disassembly (GO:0051081)2.30608255
143maturation of SSU-rRNA (GO:0030490)2.30448206
144response to peptidoglycan (GO:0032494)2.30300164
145myeloid dendritic cell differentiation (GO:0043011)2.29977348
146endosome to pigment granule transport (GO:0043485)2.29652928
147endosome to melanosome transport (GO:0035646)2.29652928
148NIK/NF-kappaB signaling (GO:0038061)2.29358903
149blastocyst development (GO:0001824)2.29038759
150fusion of sperm to egg plasma membrane (GO:0007342)2.28968355
151regulation of type I interferon-mediated signaling pathway (GO:0060338)2.28811174
152regulation of ubiquitin-protein transferase activity (GO:0051438)2.28425994
153negative regulation of type 2 immune response (GO:0002829)2.27310829
154response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.27229100
155response to host immune response (GO:0052572)2.27229100
156regulation of tolerance induction (GO:0002643)2.27138091
157N-acetylneuraminate metabolic process (GO:0006054)2.27063057
158epithelial cell differentiation involved in prostate gland development (GO:0060742)2.26638453
159regulation of antigen processing and presentation (GO:0002577)2.26296780
160positive regulation of interferon-alpha production (GO:0032727)2.25851310
161positive regulation of receptor recycling (GO:0001921)2.23686500
162regulation of ligase activity (GO:0051340)2.22889507
163response to thyroid hormone (GO:0097066)2.22751719
164regulation of T-helper 2 cell differentiation (GO:0045628)2.22576840
165positive regulation of cell cycle arrest (GO:0071158)2.22486572
166response to interferon-alpha (GO:0035455)2.22269005
167mannose metabolic process (GO:0006013)2.21809549
168regulation of translation in response to stress (GO:0043555)2.21462976
169oligosaccharide catabolic process (GO:0009313)2.20665027
170regulation of defense response to virus by virus (GO:0050690)2.20158099
171negative regulation of glycoprotein biosynthetic process (GO:0010561)2.19881551
172T-helper 1 type immune response (GO:0042088)2.16711863
173stress fiber assembly (GO:0043149)2.16066389
174positive regulation of macrophage cytokine production (GO:0060907)2.15901390
175positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.15618081
176macrophage activation (GO:0042116)2.13117355

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.79090784
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.34228200
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.31368833
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.91692312
5IRF8_21731497_ChIP-ChIP_J774_Mouse2.86795314
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.56497166
7* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.49703630
8* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.39853999
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.33000071
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.27587224
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.27104299
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.22340639
13KDM2B_26808549_Chip-Seq_SUP-B15_Human2.21834947
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.20288622
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.08533075
16* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.06460969
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.05432863
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.04031921
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.03446367
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.01963885
21TCF7_22412390_ChIP-Seq_EML_Mouse2.01648728
22* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.01515023
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.98165935
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.96213049
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.95381659
26SCL_19346495_ChIP-Seq_HPC-7_Human1.95052704
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.91868194
28RUNX_20019798_ChIP-Seq_JUKART_Human1.89287891
29E2F4_17652178_ChIP-ChIP_JURKAT_Human1.89171059
30AR_21909140_ChIP-Seq_LNCAP_Human1.88433346
31LXR_22292898_ChIP-Seq_THP-1_Human1.86325755
32KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.86123046
33SPI1_23547873_ChIP-Seq_NB4_Human1.82567374
34STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.82087332
35IRF8_27001747_Chip-Seq_BMDM_Mouse1.78118582
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.77813248
37MYC_22102868_ChIP-Seq_BL_Human1.77189028
38* VDR_23849224_ChIP-Seq_CD4+_Human1.76047535
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.75546108
40* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.75107374
41Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.74100691
42KDM2B_26808549_Chip-Seq_DND41_Human1.74004026
43VDR_21846776_ChIP-Seq_THP-1_Human1.73575880
44MYC_18358816_ChIP-ChIP_MESCs_Mouse1.73158596
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.73041531
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.72465536
47TFEB_21752829_ChIP-Seq_HELA_Human1.70222488
48PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.69777647
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.69409678
50MYC_19079543_ChIP-ChIP_MESCs_Mouse1.67473375
51* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.67275301
52ESR2_21235772_ChIP-Seq_MCF-7_Human1.64875888
53NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64472303
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.64381004
55KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.63145631
56GATA1_19941827_ChIP-Seq_MEL_Mouse1.63142653
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.62594209
58GATA2_21666600_ChIP-Seq_HMVEC_Human1.59106016
59XRN2_22483619_ChIP-Seq_HELA_Human1.57863059
60NELFA_20434984_ChIP-Seq_ESCs_Mouse1.55707468
61SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.55273804
62RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.54749031
63MYC_19030024_ChIP-ChIP_MESCs_Mouse1.54443426
64CLOCK_20551151_ChIP-Seq_293T_Human1.53591645
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.53416266
66ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.53333206
67TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.52551740
68KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.50714087
69TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.50462775
70BRD4_27068464_Chip-Seq_AML-cells_Mouse1.50316784
71TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.49862013
72DCP1A_22483619_ChIP-Seq_HELA_Human1.47846935
73RACK7_27058665_Chip-Seq_MCF-7_Human1.46279752
74TP63_17297297_ChIP-ChIP_HaCaT_Human1.46133532
75PPARA_22158963_ChIP-Seq_LIVER_Mouse1.44731357
76STAT4_19710469_ChIP-ChIP_TH1__Mouse1.44663275
77GATA1_19941826_ChIP-Seq_K562_Human1.43645977
78MYB_26560356_Chip-Seq_TH2_Human1.41663108
79RUNX1_22412390_ChIP-Seq_EML_Mouse1.40865248
80RXR_22158963_ChIP-Seq_LIVER_Mouse1.40400241
81CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.39755650
82GABP_19822575_ChIP-Seq_HepG2_Human1.37149335
83HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35988574
84MAF_26560356_Chip-Seq_TH1_Human1.35881213
85SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.32500761
86GATA1_22025678_ChIP-Seq_K562_Human1.31995721
87* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.31991708
88STAT6_21828071_ChIP-Seq_BEAS2B_Human1.31931262
89KDM5A_27292631_Chip-Seq_BREAST_Human1.29775675
90ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28837363
91MYB_26560356_Chip-Seq_TH1_Human1.28162985
92HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.27877895
93RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.27452369
94ELK3_25401928_ChIP-Seq_HUVEC_Human1.26456142
95TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25949059
96VDR_24763502_ChIP-Seq_THP-1_Human1.25911676
97SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.25810463
98KDM2B_26808549_Chip-Seq_JURKAT_Human1.25386571
99VDR_24787735_ChIP-Seq_THP-1_Human1.25309954
100SMAD_19615063_ChIP-ChIP_OVARY_Human1.24430506
101FOXP3_21729870_ChIP-Seq_TREG_Human1.23992815
102CIITA_25753668_ChIP-Seq_RAJI_Human1.22938765
103GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21660914
104SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21517647
105LXR_22158963_ChIP-Seq_LIVER_Mouse1.21312925
106TBX20_22080862_ChIP-Seq_HEART_Mouse1.20432563
107TBX20_22328084_ChIP-Seq_HEART_Mouse1.20432563
108KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18530731
109KDM2B_26808549_Chip-Seq_K562_Human1.17679762
110UTX_26944678_Chip-Seq_JUKART_Human1.17424941
111CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.14599801
112TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14394145
113KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13180117
114NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.12306690
115GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12164624
116MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12004195
117CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10183244
118KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10116902
119ELK1_19687146_ChIP-ChIP_HELA_Human1.09318707
120* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08488459
121E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08193253
122GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07094310
123* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06698575
124LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06185564
125RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05968035
126PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05260447
127CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05086101
128FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.04661802
129FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04358873
130STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03968366
131MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03592624
132E2F1_21310950_ChIP-Seq_MCF-7_Human1.03568647
133GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02503400
134TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02457342
135EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02424973
136* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02263522
137TTF2_22483619_ChIP-Seq_HELA_Human1.02053792
138GATA2_19941826_ChIP-Seq_K562_Human1.01987771
139PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01814358
140* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.01478086
141STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00989042
142P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00831939
143CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00251637
144SPI1_23127762_ChIP-Seq_K562_Human1.00245235
145PU_27001747_Chip-Seq_BMDM_Mouse0.99824445
146MYCN_18555785_ChIP-Seq_MESCs_Mouse0.99081089
147* NCOR1_26117541_ChIP-Seq_K562_Human0.98690920
148SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98648417
149POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.98615402
150PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98591900
151SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98116830
152MAF_26560356_Chip-Seq_TH2_Human0.97170313
153SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95416847
154TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95142593
155TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.94934878
156SRF_21415370_ChIP-Seq_HL-1_Mouse0.94794990
157PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94755397
158FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.94068396
159CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93899189

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.59212450
2MP0003693_abnormal_embryo_hatching3.41277706
3MP0001835_abnormal_antigen_presentation2.65903952
4MP0009840_abnormal_foam_cell2.64750185
5MP0000685_abnormal_immune_system2.38304595
6MP0006054_spinal_hemorrhage2.18023755
7MP0002396_abnormal_hematopoietic_system2.09373686
8MP0004957_abnormal_blastocyst_morpholog2.08735091
9MP0003111_abnormal_nucleus_morphology2.05963511
10MP0003172_abnormal_lysosome_physiology1.92127255
11MP0003436_decreased_susceptibility_to1.90829559
12MP0010352_gastrointestinal_tract_polyps1.90565593
13MP0002419_abnormal_innate_immunity1.86957791
14MP0009333_abnormal_splenocyte_physiolog1.83699605
15MP0002452_abnormal_antigen_presenting1.81822708
16MP0008260_abnormal_autophagy1.81445613
17MP0009785_altered_susceptibility_to1.80237897
18MP0005000_abnormal_immune_tolerance1.76781670
19MP0005451_abnormal_body_composition1.76557264
20MP0006082_CNS_inflammation1.76497416
21MP0005377_hearing/vestibular/ear_phenot1.75738478
22MP0003878_abnormal_ear_physiology1.75738478
23MP0005671_abnormal_response_to1.74575196
24MP0003690_abnormal_glial_cell1.70210670
25MP0005025_abnormal_response_to1.68208421
26MP0003077_abnormal_cell_cycle1.67935406
27MP0003300_gastrointestinal_ulcer1.67152607
28MP0005397_hematopoietic_system_phenotyp1.66374077
29MP0001545_abnormal_hematopoietic_system1.66374077
30MP0001819_abnormal_immune_cell1.66084787
31MP0010094_abnormal_chromosome_stability1.65770188
32MP0002420_abnormal_adaptive_immunity1.65499786
33MP0003303_peritoneal_inflammation1.60512705
34MP0001800_abnormal_humoral_immune1.60476325
35MP0002723_abnormal_immune_serum1.59693733
36MP0010307_abnormal_tumor_latency1.59538175
37MP0003091_abnormal_cell_migration1.55162139
38MP0001958_emphysema1.54148765
39MP0001873_stomach_inflammation1.53289534
40MP0003866_abnormal_defecation1.53253961
41MP0002398_abnormal_bone_marrow1.51526961
42MP0005464_abnormal_platelet_physiology1.49011717
43MP0000490_abnormal_crypts_of1.48864059
44MP0002148_abnormal_hypersensitivity_rea1.47286218
45MP0004808_abnormal_hematopoietic_stem1.44143257
46MP0001790_abnormal_immune_system1.43141955
47MP0005387_immune_system_phenotype1.43141955
48MP0003183_abnormal_peptide_metabolism1.41955237
49MP0005410_abnormal_fertilization1.41134379
50MP0003566_abnormal_cell_adhesion1.40082162
51MP0002405_respiratory_system_inflammati1.39606108
52MP0003828_pulmonary_edema1.39336011
53MP0000716_abnormal_immune_system1.38552147
54MP0010155_abnormal_intestine_physiology1.37700688
55MP0004947_skin_inflammation1.37437014
56MP0002722_abnormal_immune_system1.37029625
57MP0009278_abnormal_bone_marrow1.36519772
58MP0000689_abnormal_spleen_morphology1.34764485
59MP0008438_abnormal_cutaneous_collagen1.34559537
60MP0003075_altered_response_to1.33637905
61MP0002166_altered_tumor_susceptibility1.32950986
62MP0002429_abnormal_blood_cell1.31937897
63MP0001533_abnormal_skeleton_physiology1.29778672
64MP0003045_fibrosis1.29446270
65MP0005666_abnormal_adipose_tissue1.29397596
66MP0005275_abnormal_skin_tensile1.28799198
67MP0008007_abnormal_cellular_replicative1.27190504
68MP0005409_darkened_coat_color1.26592687
69MP0005670_abnormal_white_adipose1.25832357
70MP0003448_altered_tumor_morphology1.25458923
71MP0000465_gastrointestinal_hemorrhage1.23830690
72MP0002933_joint_inflammation1.23008993
73MP0004381_abnormal_hair_follicle1.22446392
74MP0005075_abnormal_melanosome_morpholog1.22393798
75MP0001845_abnormal_inflammatory_respons1.21834335
76MP0003279_aneurysm1.20731526
77MP0005310_abnormal_salivary_gland1.20159583
78MP0005023_abnormal_wound_healing1.16621323
79MP0003656_abnormal_erythrocyte_physiolo1.14511085
80MP0003763_abnormal_thymus_physiology1.14326223
81MP0005164_abnormal_response_to1.12607495
82MP0004883_abnormal_blood_vessel1.09811971
83MP0000858_altered_metastatic_potential1.08962880
84MP0004130_abnormal_muscle_cell1.08680480
85MP0004510_myositis1.08402522
86MP0008058_abnormal_DNA_repair1.07863443
87MP0001756_abnormal_urination1.06829892
88MP0003191_abnormal_cellular_cholesterol1.05936831
89MP0000920_abnormal_myelination1.04848797
90MP0003453_abnormal_keratinocyte_physiol1.04631723
91MP0008932_abnormal_embryonic_tissue1.04344102
92MP0000372_irregular_coat_pigmentation1.04077934
93MP0000703_abnormal_thymus_morphology1.03671152
94MP0000383_abnormal_hair_follicle1.03249751
95MP0009115_abnormal_fat_cell1.03146053
96MP0003329_amyloid_beta_deposits1.02988712
97* MP0001730_embryonic_growth_arrest1.02551615
98MP0000358_abnormal_cell_content/0.99975345
99MP0004185_abnormal_adipocyte_glucose0.99963463
100MP0002006_tumorigenesis0.98949129
101MP0002019_abnormal_tumor_incidence0.97179643
102MP0002971_abnormal_brown_adipose0.96105135
103MP0000343_altered_response_to0.95617755
104MP0005375_adipose_tissue_phenotype0.95506876
105MP0005166_decreased_susceptibility_to0.94525684
106MP0005076_abnormal_cell_differentiation0.94035982
107MP0008469_abnormal_protein_level0.92727523
108MP0008004_abnormal_stomach_pH0.91908985
109MP0003724_increased_susceptibility_to0.91852532
110MP0010678_abnormal_skin_adnexa0.91767787
111MP0002139_abnormal_hepatobiliary_system0.91431881
112MP0000249_abnormal_blood_vessel0.90148044
113MP0002136_abnormal_kidney_physiology0.89291102
114MP0005503_abnormal_tendon_morphology0.89107310
115MP0005390_skeleton_phenotype0.88868430
116MP0001849_ear_inflammation0.88739681
117MP0004858_abnormal_nervous_system0.88452490
118MP0000313_abnormal_cell_death0.88427865
119MP0000350_abnormal_cell_proliferation0.88042424
120MP0002998_abnormal_bone_remodeling0.87620882
121MP0010234_abnormal_vibrissa_follicle0.87364824
122MP0001542_abnormal_bone_strength0.86207109
123MP0005365_abnormal_bile_salt0.86149435
124MP0003705_abnormal_hypodermis_morpholog0.84553168
125MP0002877_abnormal_melanocyte_morpholog0.83647108
126MP0001853_heart_inflammation0.82936910
127MP0000604_amyloidosis0.80919414
128MP0005621_abnormal_cell_physiology0.80731410
129MP0003795_abnormal_bone_structure0.80569136
130MP0000767_abnormal_smooth_muscle0.79191455
131MP0002138_abnormal_hepatobiliary_system0.79031834
132MP0001851_eye_inflammation0.78744017
133MP0000371_diluted_coat_color0.78698611
134MP0008057_abnormal_DNA_replication0.78599269
135MP0002132_abnormal_respiratory_system0.78035291
136MP0000569_abnormal_digit_pigmentation0.76893150

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)5.29372268
2Abnormality of liposaccharide metabolism (HP:0010968)5.29372268
3Abnormality of glycosphingolipid metabolism (HP:0004343)5.29372268
4Increased cerebral lipofuscin (HP:0011813)5.13374881
5Vacuolated lymphocytes (HP:0001922)4.73998441
6Increased neuronal autofluorescent lipopigment (HP:0002074)4.36042785
7Abnormality of macrophages (HP:0004311)4.26424211
8Recurrent abscess formation (HP:0002722)4.08845051
9Eczematoid dermatitis (HP:0000976)3.74803050
10Dysostosis multiplex (HP:0000943)3.59515138
11Recurrent bacterial skin infections (HP:0005406)3.45876079
12Petechiae (HP:0000967)3.40119051
13Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.34494415
14Systemic lupus erythematosus (HP:0002725)3.26272042
15Chronic otitis media (HP:0000389)3.15274331
16Interstitial pulmonary disease (HP:0006530)3.07289756
17Nasal polyposis (HP:0100582)3.06982230
18Osteolytic defects of the hand bones (HP:0009699)3.04206935
19Osteolytic defects of the phalanges of the hand (HP:0009771)3.04206935
20Pustule (HP:0200039)3.01857298
21Poor head control (HP:0002421)2.97480448
22Loss of speech (HP:0002371)2.90905462
23Abnormality of the nasal mucosa (HP:0000433)2.88359925
24Increased IgE level (HP:0003212)2.77648398
25Colitis (HP:0002583)2.71402995
26Diminished motivation (HP:0000745)2.70380792
27Recurrent fungal infections (HP:0002841)2.69467890
28Cerebral hypomyelination (HP:0006808)2.59582771
29Protrusio acetabuli (HP:0003179)2.58366431
30IgM deficiency (HP:0002850)2.56129266
31Recurrent bronchitis (HP:0002837)2.55069562
32Mucopolysacchariduria (HP:0008155)2.55057957
33Urinary glycosaminoglycan excretion (HP:0003541)2.55057957
34Personality changes (HP:0000751)2.53981901
35Vertebral compression fractures (HP:0002953)2.52914816
36Abnormality of the anterior horn cell (HP:0006802)2.52274552
37Degeneration of anterior horn cells (HP:0002398)2.52274552
38Complement deficiency (HP:0004431)2.50880611
39Abnormality of complement system (HP:0005339)2.49115802
40Apathy (HP:0000741)2.48903276
41Premature rupture of membranes (HP:0001788)2.48347104
42Retrobulbar optic neuritis (HP:0100654)2.48268652
43Optic neuritis (HP:0100653)2.48268652
44Obstructive lung disease (HP:0006536)2.48223301
45Chronic obstructive pulmonary disease (HP:0006510)2.48223301
46Abnormal number of erythroid precursors (HP:0012131)2.45987556
47Purpura (HP:0000979)2.44163353
48Abnormality of the umbilical cord (HP:0010881)2.41785341
49Disinhibition (HP:0000734)2.39672455
50Thrombocytosis (HP:0001894)2.39248645
51Cervical subluxation (HP:0003308)2.37663084
52Cellulitis (HP:0100658)2.37022096
53Abnormality of cells of the erythroid lineage (HP:0012130)2.36524070
54Prolonged bleeding time (HP:0003010)2.35252827
55Aortic aneurysm (HP:0004942)2.34960700
56Abnormal delayed hypersensitivity skin test (HP:0002963)2.32110183
57Segmental peripheral demyelination/remyelination (HP:0003481)2.31697916
58Glomerulonephritis (HP:0000099)2.31465034
59Gastrointestinal infarctions (HP:0005244)2.27798115
60Meningitis (HP:0001287)2.24716836
61Entropion (HP:0000621)2.21588481
62Polycythemia (HP:0001901)2.20987279
63Gingival bleeding (HP:0000225)2.20883245
64Epistaxis (HP:0000421)2.20811476
65Myositis (HP:0100614)2.20497864
66Elevated erythrocyte sedimentation rate (HP:0003565)2.20089964
67Amyloidosis (HP:0011034)2.19743036
68Aneurysm (HP:0002617)2.19274483
69Recurrent skin infections (HP:0001581)2.17220895
70Abnormality of mucopolysaccharide metabolism (HP:0011020)2.16982142
71Abnormality of polysaccharide metabolism (HP:0011012)2.16982142
72Abnormality of glycosaminoglycan metabolism (HP:0004371)2.16982142
73Deep venous thrombosis (HP:0002625)2.15465612
74Recurrent gram-negative bacterial infections (HP:0005420)2.15338032
75Recurrent viral infections (HP:0004429)2.13308145
76Hemorrhage of the eye (HP:0011885)2.12097231
77Keratoconjunctivitis sicca (HP:0001097)2.11942223
78Myocardial infarction (HP:0001658)2.09659338
79Pulmonary infiltrates (HP:0002113)2.09657190
80Gastrointestinal stroma tumor (HP:0100723)2.09631087
81Autoimmune thrombocytopenia (HP:0001973)2.09551817
82Abnormality of the vasculature of the conjunctiva (HP:0008054)2.08693755
83Abnormality of the distal phalanges of the toes (HP:0010182)2.05186992
84Vasculitis (HP:0002633)2.04650042
85Abnormality of the fingertips (HP:0001211)2.02558793
86Ankle contracture (HP:0006466)1.99837120
87Trismus (HP:0000211)1.99628951
88Peritonitis (HP:0002586)1.99521045
89Broad face (HP:0000283)1.97794354
90Multiple enchondromatosis (HP:0005701)1.97581796
91Neurofibrillary tangles (HP:0002185)1.95911367
92Conjunctival telangiectasia (HP:0000524)1.95683723
93Hepatosplenomegaly (HP:0001433)1.95422461
94Axonal loss (HP:0003447)1.95207157
95Agnosia (HP:0010524)1.94057345
96Obstructive sleep apnea (HP:0002870)1.92393458
97Bronchitis (HP:0012387)1.92268991
98Dilatation of the ascending aorta (HP:0005111)1.90878798
99Fatigue (HP:0012378)1.90563754
100Emphysema (HP:0002097)1.90486702
101Hemoptysis (HP:0002105)1.89924208
102Encephalitis (HP:0002383)1.89042291
103Pulmonary embolism (HP:0002204)1.88755753
104Thin bony cortex (HP:0002753)1.87639004
105Cheilitis (HP:0100825)1.87525955
106Progressive neurologic deterioration (HP:0002344)1.84352330
107Keratoconjunctivitis (HP:0001096)1.83677939
108Hematochezia (HP:0002573)1.83603406
109Abnormality of the peritoneum (HP:0002585)1.83334230
110Abnormality of T cells (HP:0002843)1.82175431
111Increased variability in muscle fiber diameter (HP:0003557)1.82001659
112Agammaglobulinemia (HP:0004432)1.81176936
113Hypoplasia of the capital femoral epiphysis (HP:0003090)1.80835422
114Abnormality of T cell physiology (HP:0011840)1.80504349
115Aplastic anemia (HP:0001915)1.80306146
116Microretrognathia (HP:0000308)1.80116640
117Micronodular cirrhosis (HP:0001413)1.78939056
118Spondylolisthesis (HP:0003302)1.78224331
119Carpal bone hypoplasia (HP:0001498)1.77638473
120Recurrent cutaneous fungal infections (HP:0011370)1.76901662
121Chronic mucocutaneous candidiasis (HP:0002728)1.76901662
122Prolonged neonatal jaundice (HP:0006579)1.75655853
123Nephritis (HP:0000123)1.75064123
124Osteomyelitis (HP:0002754)1.74455904
125Gingivitis (HP:0000230)1.74432721
126Mucosal telangiectasiae (HP:0100579)1.74403897
127Urticaria (HP:0001025)1.74175861
128Onion bulb formation (HP:0003383)1.73269087
129Asymmetric septal hypertrophy (HP:0001670)1.73094151
130Gastrointestinal inflammation (HP:0004386)1.72603713
131Rough bone trabeculation (HP:0100670)1.72517884
132Hypergammaglobulinemia (HP:0010702)1.71827528
133Cerebral aneurysm (HP:0004944)1.70733940
134Abnormality of eosinophils (HP:0001879)1.70527229
135Leukocytosis (HP:0001974)1.69758425
136Increased connective tissue (HP:0009025)1.69485433
137Inflammation of the large intestine (HP:0002037)1.69289151
138Abnormality of T cell number (HP:0011839)1.68678412
139Orchitis (HP:0100796)1.68153547
140Vascular tortuosity (HP:0004948)1.67850999
141Abnormality of skeletal muscle fiber size (HP:0012084)1.67368657
142Global brain atrophy (HP:0002283)1.66720150
143Restrictive lung disease (HP:0002091)1.66389478
144Short nail (HP:0001799)1.66111689
145Hypertriglyceridemia (HP:0002155)1.65702168
146Selective tooth agenesis (HP:0001592)1.65654512
147Broad distal phalanx of finger (HP:0009836)1.62818262
148T lymphocytopenia (HP:0005403)1.62446217
149Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.62332766
150Cutaneous melanoma (HP:0012056)1.61946194
151Postnatal microcephaly (HP:0005484)1.61311537
152Tongue fasciculations (HP:0001308)1.60348980
153Spontaneous hematomas (HP:0007420)1.59136033
154Mediastinal lymphadenopathy (HP:0100721)1.59075898
155Beaking of vertebral bodies (HP:0004568)1.58967777

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.05323875
2EPHA24.02831061
3WEE13.67182516
4PRPF4B3.39902462
5MAP4K12.85290712
6TESK22.50166206
7RIPK12.23265615
8TESK12.17387752
9MAP3K132.16361224
10EIF2AK12.14048119
11NEK22.07825890
12BLK2.00344066
13TSSK61.96540316
14SCYL21.96046342
15TRIB31.94614300
16LRRK21.90372682
17TBK11.84589440
18PDK31.70433826
19PDK41.70433826
20BRSK21.70156965
21ZAP701.67642242
22PAK41.66946852
23MAP3K141.62147273
24TYK21.61293864
25PIM21.58164594
26STK101.56970262
27PDK21.56967236
28SIK11.55451924
29KIT1.52597393
30KSR21.47736126
31ICK1.47681936
32CDK121.47661568
33FGFR31.44123399
34NME21.42874946
35EEF2K1.38404471
36KDR1.37616413
37CDC42BPA1.32436798
38FES1.32063615
39PDGFRA1.29499444
40NEK11.28859953
41MAP3K111.25148242
42ERN11.25147198
43RPS6KB21.24772459
44PDPK11.19295199
45MAPKAPK51.17125649
46RPS6KA41.15872309
47NEK91.13400795
48EPHA31.10799370
49TNK21.09907300
50TGFBR21.08547513
51EIF2AK31.07941480
52DYRK31.07808385
53MAP3K11.06037363
54RET1.05974060
55SMG11.05353704
56DDR21.03733660
57MAP3K81.01958883
58PDK11.00870207
59CSF1R0.97164284
60PAK10.96769329
61CAMKK20.95965854
62MARK20.95425141
63PKN20.93724844
64FGFR40.91930933
65PDGFRB0.90696432
66JAK30.89928763
67IRAK40.89688957
68TAOK20.88928356
69ARAF0.88786419
70EPHB10.87934043
71MAP3K20.87440491
72MAP3K70.86765110
73MST1R0.85661473
74TRPM70.85271280
75BTK0.84832758
76HIPK20.84486687
77BRSK10.84080623
78MAPK70.83738480
79MAPK120.82105943
80TTK0.79400899
81SGK30.78736765
82MAPK110.78139719
83MAP2K20.78091950
84PRKD20.78026726
85MAP3K60.77034344
86ILK0.76401314
87STK160.76352734
88SYK0.73993733
89JAK10.73371175
90PIM10.73247985
91AURKB0.72634589
92PASK0.72553593
93FGR0.70583219
94IKBKB0.70309375
95IKBKE0.69567968
96TGFBR10.68766475
97MST40.67064483
98CAMK1D0.66588957
99PLK10.65756565
100CDK60.65747189
101MARK30.65423114
102PTK60.65158063
103NLK0.63079833
104MTOR0.62880845
105WNK10.62091780
106CAMKK10.61408230
107BMX0.60362671
108IRAK30.60220531
109RPS6KA20.58532568
110YES10.57774235
111RIPK40.57381664
112TTN0.57110241
113RPS6KL10.56677937
114RPS6KC10.56677937
115STK40.56616714
116MAP2K30.56595089
117GRK60.55786347
118CSK0.55422367
119ITK0.55224211
120MYLK0.52852955
121CLK10.52664983
122PLK40.52135517
123MELK0.51888547
124HCK0.51820104
125PRKAA20.51504337
126MAP3K30.51316909
127TYRO30.51031128
128MAPKAPK20.50711420
129SGK20.50500719
130MAPKAPK30.50491553
131MAP3K120.50407724
132DYRK1B0.50281925
133AKT30.49890736
134PRKD10.49791637
135LIMK10.48785267
136LYN0.48281328
137CDC70.47100650
138FYN0.47049559
139CDK40.45928169
140LCK0.45129536
141CCNB10.45026610
142ALK0.44378645
143PRKCD0.43757200
144MATK0.43513269
145RPS6KA60.42970960
146TLK10.41939076
147PNCK0.39250089
148ATR0.38814023
149JAK20.38038029
150TXK0.37955863
151PBK0.37250340
152ACVR1B0.37238438
153SRPK10.35044171
154TEC0.34102552
155PLK30.32694862

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.49581626
2Lysosome_Homo sapiens_hsa041422.81740288
3Antigen processing and presentation_Homo sapiens_hsa046122.44434736
4Staphylococcus aureus infection_Homo sapiens_hsa051502.42463616
5DNA replication_Homo sapiens_hsa030302.35314109
6Other glycan degradation_Homo sapiens_hsa005112.26295065
7Vitamin B6 metabolism_Homo sapiens_hsa007502.13255391
8Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.91953169
9Glycosaminoglycan degradation_Homo sapiens_hsa005311.89850534
10Base excision repair_Homo sapiens_hsa034101.84633206
11Pentose phosphate pathway_Homo sapiens_hsa000301.83585979
12Legionellosis_Homo sapiens_hsa051341.77466369
13Autoimmune thyroid disease_Homo sapiens_hsa053201.75305100
14Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.72414592
15RNA transport_Homo sapiens_hsa030131.67960000
16Graft-versus-host disease_Homo sapiens_hsa053321.67734367
17Ribosome_Homo sapiens_hsa030101.67288013
18Allograft rejection_Homo sapiens_hsa053301.67116553
19Shigellosis_Homo sapiens_hsa051311.63030771
20Leishmaniasis_Homo sapiens_hsa051401.62661484
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.62379505
22Spliceosome_Homo sapiens_hsa030401.53856699
23Mismatch repair_Homo sapiens_hsa034301.51362356
24Cell cycle_Homo sapiens_hsa041101.51018724
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.48314620
26Osteoclast differentiation_Homo sapiens_hsa043801.39061998
27Regulation of autophagy_Homo sapiens_hsa041401.34790882
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.33955979
29Epstein-Barr virus infection_Homo sapiens_hsa051691.32888441
30Non-small cell lung cancer_Homo sapiens_hsa052231.32117311
31Leukocyte transendothelial migration_Homo sapiens_hsa046701.31463150
32Primary immunodeficiency_Homo sapiens_hsa053401.28864396
33B cell receptor signaling pathway_Homo sapiens_hsa046621.28744029
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26442052
35Homologous recombination_Homo sapiens_hsa034401.26148259
36Complement and coagulation cascades_Homo sapiens_hsa046101.25377710
37VEGF signaling pathway_Homo sapiens_hsa043701.25002665
38Phagosome_Homo sapiens_hsa041451.24962685
39Apoptosis_Homo sapiens_hsa042101.24323975
40RNA polymerase_Homo sapiens_hsa030201.24092200
41Measles_Homo sapiens_hsa051621.18453790
42NF-kappa B signaling pathway_Homo sapiens_hsa040641.18370261
43Tuberculosis_Homo sapiens_hsa051521.17604709
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.17151208
45Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16557992
46p53 signaling pathway_Homo sapiens_hsa041151.15798645
47Viral carcinogenesis_Homo sapiens_hsa052031.13871078
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.11400787
49Pyrimidine metabolism_Homo sapiens_hsa002401.09669196
50* Endocytosis_Homo sapiens_hsa041441.08983581
51Salmonella infection_Homo sapiens_hsa051321.08090021
52Asthma_Homo sapiens_hsa053101.08046204
53Nucleotide excision repair_Homo sapiens_hsa034201.06588505
54Intestinal immune network for IgA production_Homo sapiens_hsa046721.06174022
55Renin-angiotensin system_Homo sapiens_hsa046141.04466367
56Non-homologous end-joining_Homo sapiens_hsa034501.03591344
57Renal cell carcinoma_Homo sapiens_hsa052111.02335756
58Notch signaling pathway_Homo sapiens_hsa043301.01909416
59Type I diabetes mellitus_Homo sapiens_hsa049401.00255277
60Adipocytokine signaling pathway_Homo sapiens_hsa049201.00052098
61Prolactin signaling pathway_Homo sapiens_hsa049170.99109716
62Pertussis_Homo sapiens_hsa051330.98491803
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.97796767
64Toxoplasmosis_Homo sapiens_hsa051450.97410646
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.97284296
66Prion diseases_Homo sapiens_hsa050200.96688886
67Toll-like receptor signaling pathway_Homo sapiens_hsa046200.95968442
68Rheumatoid arthritis_Homo sapiens_hsa053230.95097185
69Fructose and mannose metabolism_Homo sapiens_hsa000510.94877711
70Hematopoietic cell lineage_Homo sapiens_hsa046400.93060325
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.92479715
72Herpes simplex infection_Homo sapiens_hsa051680.92040863
73Amoebiasis_Homo sapiens_hsa051460.90620208
74Influenza A_Homo sapiens_hsa051640.89144624
75Endometrial cancer_Homo sapiens_hsa052130.88067443
76Insulin resistance_Homo sapiens_hsa049310.87973221
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86481496
78mTOR signaling pathway_Homo sapiens_hsa041500.84397772
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.83280674
80Collecting duct acid secretion_Homo sapiens_hsa049660.83181253
81Sphingolipid metabolism_Homo sapiens_hsa006000.82411712
82Choline metabolism in cancer_Homo sapiens_hsa052310.82339318
83Focal adhesion_Homo sapiens_hsa045100.82280876
84Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82119516
85PPAR signaling pathway_Homo sapiens_hsa033200.80669208
86GnRH signaling pathway_Homo sapiens_hsa049120.77926505
87Vibrio cholerae infection_Homo sapiens_hsa051100.77337636
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76999397
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.75244852
90Hepatitis B_Homo sapiens_hsa051610.75124383
91Malaria_Homo sapiens_hsa051440.74355595
92N-Glycan biosynthesis_Homo sapiens_hsa005100.71855397
93Thyroid cancer_Homo sapiens_hsa052160.71457620
94Insulin signaling pathway_Homo sapiens_hsa049100.71118291
95Small cell lung cancer_Homo sapiens_hsa052220.69612713
96Chronic myeloid leukemia_Homo sapiens_hsa052200.69369483
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68577088
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68273747
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67464270
100Systemic lupus erythematosus_Homo sapiens_hsa053220.67363187
101HTLV-I infection_Homo sapiens_hsa051660.65387651
102Glioma_Homo sapiens_hsa052140.64486388
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63798064
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63712674
105Bladder cancer_Homo sapiens_hsa052190.63073061
106Mineral absorption_Homo sapiens_hsa049780.63025423
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62051458
108Estrogen signaling pathway_Homo sapiens_hsa049150.61717153
109Dorso-ventral axis formation_Homo sapiens_hsa043200.61618326
110Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60466867
111Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59775502
112Oocyte meiosis_Homo sapiens_hsa041140.59412232
113FoxO signaling pathway_Homo sapiens_hsa040680.59173402
114Proteoglycans in cancer_Homo sapiens_hsa052050.59091723
115Prostate cancer_Homo sapiens_hsa052150.58744335
116ErbB signaling pathway_Homo sapiens_hsa040120.58221231
117SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58078782
118Glutathione metabolism_Homo sapiens_hsa004800.57660772
119Galactose metabolism_Homo sapiens_hsa000520.56613935
120Jak-STAT signaling pathway_Homo sapiens_hsa046300.55262806
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54314338
122Purine metabolism_Homo sapiens_hsa002300.54180037
123Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52681197
124Folate biosynthesis_Homo sapiens_hsa007900.52384927
125T cell receptor signaling pathway_Homo sapiens_hsa046600.52261922
126Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51923248
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51252618
128Protein export_Homo sapiens_hsa030600.51007335
129Inositol phosphate metabolism_Homo sapiens_hsa005620.50682580
130Pancreatic cancer_Homo sapiens_hsa052120.50214963
131ABC transporters_Homo sapiens_hsa020100.49981368
132Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49919992
133Chemokine signaling pathway_Homo sapiens_hsa040620.49829359
134RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49791135
135TNF signaling pathway_Homo sapiens_hsa046680.49698391
136HIF-1 signaling pathway_Homo sapiens_hsa040660.49502260
137Acute myeloid leukemia_Homo sapiens_hsa052210.49184256
138Histidine metabolism_Homo sapiens_hsa003400.48416057
139ECM-receptor interaction_Homo sapiens_hsa045120.48235985
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47319944
141Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47305755
142Hepatitis C_Homo sapiens_hsa051600.46748261
143Colorectal cancer_Homo sapiens_hsa052100.46403414
144Viral myocarditis_Homo sapiens_hsa054160.45997029
145Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44573526
146Fanconi anemia pathway_Homo sapiens_hsa034600.44381367
147Glycerophospholipid metabolism_Homo sapiens_hsa005640.43423902
148Platelet activation_Homo sapiens_hsa046110.42641650

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