SNX10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene may play a role in regulating endosome homeostasis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.03880864
2negative regulation of interleukin-12 production (GO:0032695)4.79263928
3daunorubicin metabolic process (GO:0044597)4.71057980
4polyketide metabolic process (GO:0030638)4.71057980
5doxorubicin metabolic process (GO:0044598)4.71057980
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.58223080
7detection of molecule of bacterial origin (GO:0032490)4.33581865
8positive regulation of type 2 immune response (GO:0002830)4.27863360
9proline transport (GO:0015824)4.12347333
10response to peptidoglycan (GO:0032494)4.11617919
11phagosome maturation (GO:0090382)3.90581719
12hydrogen peroxide biosynthetic process (GO:0050665)3.78971052
13positive regulation by symbiont of host defense response (GO:0052509)3.75385040
14modulation by symbiont of host defense response (GO:0052031)3.75385040
15modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.75385040
16modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.75385040
17positive regulation by organism of defense response of other organism involved in symbiotic interact3.75385040
18modulation by symbiont of host immune response (GO:0052553)3.75385040
19synaptic vesicle exocytosis (GO:0016079)3.72763011
20detection of other organism (GO:0098543)3.72071282
21positive regulation of cellular amide metabolic process (GO:0034250)3.70258877
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.69893924
23production of molecular mediator involved in inflammatory response (GO:0002532)3.69276310
24detection of external biotic stimulus (GO:0098581)3.54966071
25neutrophil activation involved in immune response (GO:0002283)3.54736046
26regulation of gamma-delta T cell activation (GO:0046643)3.48821342
27T-helper 1 type immune response (GO:0042088)3.48593597
28cellular extravasation (GO:0045123)3.47698204
29regulation of T-helper 2 cell differentiation (GO:0045628)3.43321353
30regulation of B cell receptor signaling pathway (GO:0050855)3.42563257
31reactive oxygen species biosynthetic process (GO:1903409)3.41763020
32regulation of T cell tolerance induction (GO:0002664)3.37132479
33positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.37112698
34synaptic vesicle maturation (GO:0016188)3.35479094
35positive regulation of toll-like receptor signaling pathway (GO:0034123)3.34893253
36regulation of type 2 immune response (GO:0002828)3.31563403
37positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.29378153
38detection of bacterium (GO:0016045)3.27047487
39regulation of dendritic cell antigen processing and presentation (GO:0002604)3.26599864
40superoxide anion generation (GO:0042554)3.26521463
41regulation of short-term neuronal synaptic plasticity (GO:0048172)3.26478352
42positive regulation of chemokine biosynthetic process (GO:0045080)3.20365515
43regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.20337874
44transferrin transport (GO:0033572)3.20000883
45regulation of interleukin-12 production (GO:0032655)3.18920012
46positive regulation of mast cell activation (GO:0033005)3.17711130
47antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.17271989
48regulation of tolerance induction (GO:0002643)3.15825336
49positive regulation of interferon-alpha production (GO:0032727)3.15495434
50detection of biotic stimulus (GO:0009595)3.15372608
51macrophage activation involved in immune response (GO:0002281)3.15178822
52protein localization to synapse (GO:0035418)3.14999666
53antigen processing and presentation of endogenous antigen (GO:0019883)3.14301657
54positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.14277194
55glutamate secretion (GO:0014047)3.12329748
56respiratory burst (GO:0045730)3.12056710
57neutrophil mediated immunity (GO:0002446)3.11750268
58negative regulation of amino acid transport (GO:0051956)3.11247159
59regulation of glutamate receptor signaling pathway (GO:1900449)3.10726573
60regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.09309670
61response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.08624896
62response to host immune response (GO:0052572)3.08624896
63immunoglobulin mediated immune response (GO:0016064)3.08500013
64regulation of synaptic vesicle exocytosis (GO:2000300)3.05654027
65positive regulation of antigen processing and presentation (GO:0002579)3.05454009
66positive regulation of heat generation (GO:0031652)3.05437699
67negative regulation of T cell mediated immunity (GO:0002710)3.04834796
68B cell mediated immunity (GO:0019724)3.01247219
69mitochondrion distribution (GO:0048311)3.01188077
70ionotropic glutamate receptor signaling pathway (GO:0035235)3.00843079
71negative regulation of dendrite morphogenesis (GO:0050774)3.00529455
72positive regulation of T-helper cell differentiation (GO:0045624)2.99378082
73microglial cell activation (GO:0001774)2.99160504
74regulation of mast cell degranulation (GO:0043304)2.96796649
75T cell migration (GO:0072678)2.96706520
76positive regulation of interleukin-12 production (GO:0032735)2.96363248
77negative regulation of interleukin-17 production (GO:0032700)2.96303981
78regulation of interferon-alpha production (GO:0032647)2.95407256
79antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.95077422
80positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.94541145
81trivalent inorganic cation transport (GO:0072512)2.93652108
82ferric iron transport (GO:0015682)2.93652108
83lymphocyte chemotaxis (GO:0048247)2.93376851
84lipopolysaccharide-mediated signaling pathway (GO:0031663)2.93100266
85response to protozoan (GO:0001562)2.92314590
86regulation of antigen processing and presentation (GO:0002577)2.92137711
87positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.91743252
88regulation of T-helper cell differentiation (GO:0045622)2.91365940
89interferon-gamma-mediated signaling pathway (GO:0060333)2.90490760
90positive regulation of interleukin-10 production (GO:0032733)2.89804379
91negative regulation of lymphocyte mediated immunity (GO:0002707)2.89664896
92regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.89575586
93germinal center formation (GO:0002467)2.87218567
94neuron cell-cell adhesion (GO:0007158)2.86909929
95positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.86852076
96regulation of fever generation (GO:0031620)2.86728699
97regulation of interleukin-17 production (GO:0032660)2.86003557
98regulation of synaptic vesicle transport (GO:1902803)2.84886554
99myeloid leukocyte mediated immunity (GO:0002444)2.82858650
100vocalization behavior (GO:0071625)2.80249589
101response to histamine (GO:0034776)2.79862325
102positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.78486058
103regulation of mast cell activation (GO:0033003)2.78347963
104positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.78143067
105cellular response to interferon-gamma (GO:0071346)2.77858168
106positive regulation of tolerance induction (GO:0002645)2.75764908
107regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.75241554
108myeloid dendritic cell differentiation (GO:0043011)2.74652128
109regulation of mast cell activation involved in immune response (GO:0033006)2.73244091
110positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.71962712
111granulocyte activation (GO:0036230)2.71755921
112negative regulation of myeloid cell apoptotic process (GO:0033033)2.70632110
113ATP hydrolysis coupled proton transport (GO:0015991)2.70561196
114energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.70561196
115regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.70474702
116positive regulation of interleukin-1 beta secretion (GO:0050718)2.69208343
117response to interferon-gamma (GO:0034341)2.67375531
118gamma-aminobutyric acid signaling pathway (GO:0007214)2.66645403
119regulation of chemokine biosynthetic process (GO:0045073)2.66397610
120negative regulation of systemic arterial blood pressure (GO:0003085)2.66105325
121neutrophil activation (GO:0042119)2.65409557
122type I interferon signaling pathway (GO:0060337)2.64250026
123cellular response to type I interferon (GO:0071357)2.64250026
124regulation of glutamate secretion (GO:0014048)2.64130318
125synaptic vesicle docking involved in exocytosis (GO:0016081)2.62816379
126myeloid cell activation involved in immune response (GO:0002275)2.62298117
127glutamate receptor signaling pathway (GO:0007215)2.61422155
128neurotransmitter secretion (GO:0007269)2.60257685
129neuron-neuron synaptic transmission (GO:0007270)2.59462403
130synaptic vesicle endocytosis (GO:0048488)2.58575286
131intracellular pH reduction (GO:0051452)2.57688526
132response to type I interferon (GO:0034340)2.56200638
133response to host (GO:0075136)2.55981534
134response to host defenses (GO:0052200)2.55981534
135response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.55981534
136defense response to protozoan (GO:0042832)2.55590867
137synaptic transmission, glutamatergic (GO:0035249)2.54850046
138regulation of T-helper 1 cell differentiation (GO:0045625)2.54563411
139positive regulation of mast cell activation involved in immune response (GO:0033008)2.54135982
140positive regulation of mast cell degranulation (GO:0043306)2.54135982
141aminoglycoside antibiotic metabolic process (GO:0030647)2.52739191
142negative regulation of viral genome replication (GO:0045071)2.51821666
143positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.51537814
144positive regulation of cAMP-mediated signaling (GO:0043950)2.51388955
145response to muramyl dipeptide (GO:0032495)2.48134792
146natural killer cell mediated cytotoxicity (GO:0042267)2.46306250
147natural killer cell mediated immunity (GO:0002228)2.46306250
148neurotransmitter-gated ion channel clustering (GO:0072578)2.43624225
149regulation of interferon-beta biosynthetic process (GO:0045357)2.41395531
150serotonin receptor signaling pathway (GO:0007210)2.38057113
151positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.37917252
152regulation of excitatory postsynaptic membrane potential (GO:0060079)2.37443917
153macrophage activation (GO:0042116)2.37376917
154negative regulation of synaptic transmission, GABAergic (GO:0032229)2.36751445
155neuronal action potential propagation (GO:0019227)2.36742949
156response to interferon-alpha (GO:0035455)2.34516765
157leukocyte mediated cytotoxicity (GO:0001909)2.33234091
158negative regulation of cell killing (GO:0031342)2.32358885
159negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.32358885
160eosinophil chemotaxis (GO:0048245)2.31865849

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.93785419
2* IRF8_21731497_ChIP-ChIP_J774_Mouse4.47460938
3GBX2_23144817_ChIP-Seq_PC3_Human3.96567420
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.87819030
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.58445845
6EZH2_22144423_ChIP-Seq_EOC_Human2.97801936
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.85884729
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.82706686
9IGF1R_20145208_ChIP-Seq_DFB_Human2.79780428
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.77808091
11IKZF1_21737484_ChIP-ChIP_HCT116_Human2.70724979
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.59865357
13RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.51927646
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.51927296
15* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.50478632
16* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.43800314
17GATA1_22025678_ChIP-Seq_K562_Human2.41988811
18* IRF8_27001747_Chip-Seq_BMDM_Mouse2.38077448
19RUNX_20019798_ChIP-Seq_JUKART_Human2.31719662
20VDR_24787735_ChIP-Seq_THP-1_Human2.31542178
21* SPI1_23547873_ChIP-Seq_NB4_Human2.24881366
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.24513855
23TAF15_26573619_Chip-Seq_HEK293_Human2.16241989
24SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12933987
25* SPI1_23127762_ChIP-Seq_K562_Human2.11146872
26ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08861579
27REST_21632747_ChIP-Seq_MESCs_Mouse2.07981201
28SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.97899081
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86951237
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.81720514
31P300_19829295_ChIP-Seq_ESCs_Human1.80728290
32* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80481751
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.79003194
34* MYB_26560356_Chip-Seq_TH2_Human1.77436386
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.74126177
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.73655458
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.73406913
38* SMAD4_21799915_ChIP-Seq_A2780_Human1.72151969
39* SCL_19346495_ChIP-Seq_HPC-7_Human1.71545847
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.69377411
41VDR_24763502_ChIP-Seq_THP-1_Human1.65777993
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64729548
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.61625484
44NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60285428
45CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.57561404
46SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.54404600
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.51846165
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.49244036
49* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.48910231
50REST_18959480_ChIP-ChIP_MESCs_Mouse1.46111447
51* RUNX1_22412390_ChIP-Seq_EML_Mouse1.44517046
52PU_27001747_Chip-Seq_BMDM_Mouse1.42252498
53* GATA3_27048872_Chip-Seq_THYMUS_Human1.40408200
54JARID2_20064375_ChIP-Seq_MESCs_Mouse1.40220726
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39597103
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39327578
57CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.38721668
58AR_25329375_ChIP-Seq_VCAP_Human1.38602375
59MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.38370796
60* GATA3_26560356_Chip-Seq_TH2_Human1.38061012
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36756793
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.34705003
63FUS_26573619_Chip-Seq_HEK293_Human1.34479633
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33518788
65BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33445006
66SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.33415674
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.31164826
68SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.30637441
69RNF2_27304074_Chip-Seq_NSC_Mouse1.29610155
70E2F1_18555785_Chip-Seq_ESCs_Mouse1.28012558
71CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.27389603
72SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.26181551
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.24370556
74MTF2_20144788_ChIP-Seq_MESCs_Mouse1.24091334
75NANOG_18555785_Chip-Seq_ESCs_Mouse1.23553823
76MYB_26560356_Chip-Seq_TH1_Human1.23326625
77* MAF_26560356_Chip-Seq_TH1_Human1.23276890
78* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22943898
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22015547
80CMYC_18555785_Chip-Seq_ESCs_Mouse1.21081228
81* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21040088
82STAT3_23295773_ChIP-Seq_U87_Human1.20945568
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19252131
84STAT3_18555785_Chip-Seq_ESCs_Mouse1.17910469
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16964109
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16702732
87RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.16595617
88CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16431212
89RARB_27405468_Chip-Seq_BRAIN_Mouse1.16412250
90GATA1_19941827_ChIP-Seq_MEL_Mouse1.15961523
91SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15743306
92MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14992216
93CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14707007
94CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14123471
95CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13872957
96JARID2_20075857_ChIP-Seq_MESCs_Mouse1.13421220
97P53_22387025_ChIP-Seq_ESCs_Mouse1.13000280
98JUN_21703547_ChIP-Seq_K562_Human1.12032719
99* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.11326516
100STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.10337927
101EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09882890
102RNF2_18974828_ChIP-Seq_MESCs_Mouse1.09731077
103EZH2_18974828_ChIP-Seq_MESCs_Mouse1.09731077
104* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09214058
105SOX2_18555785_Chip-Seq_ESCs_Mouse1.08863010
106* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08691549
107MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08039322
108NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.07547791
109TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07424519
110NMYC_18555785_Chip-Seq_ESCs_Mouse1.07094265
111P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06528064
112RUNX1_27457419_Chip-Seq_LIVER_Mouse1.05922184
113GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05258863
114AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04633229
115FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04045155
116OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03812020
117VDR_22108803_ChIP-Seq_LS180_Human1.02849538
118NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02835404
119EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01470259
120CBP_20019798_ChIP-Seq_JUKART_Human1.01238646
121IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01238646
122CTCF_18555785_Chip-Seq_ESCs_Mouse1.01101278
123SMAD1_18555785_Chip-Seq_ESCs_Mouse1.01090318
124P300_18555785_Chip-Seq_ESCs_Mouse1.00814437
125GATA2_21666600_ChIP-Seq_HMVEC_Human1.00614897
126SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00443780
127SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99627277
128PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99604370
129PU1_27457419_Chip-Seq_LIVER_Mouse0.99541146
130RUNX2_22187159_ChIP-Seq_PCA_Human0.99207588
131* SOX2_21211035_ChIP-Seq_LN229_Gbm0.98795396
132TCF4_23295773_ChIP-Seq_U87_Human0.98252003
133NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97974673
134LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.97662479
135NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97477541
136NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97477541
137STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96649175
138RNF2_27304074_Chip-Seq_ESCs_Mouse0.95144459
139SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94789265
140GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94598902
141NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.92881217
142BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.92798025
143KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.92446009
144UTX_26944678_Chip-Seq_JUKART_Human0.91167855
145* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90827733
146* SMRT_27268052_Chip-Seq_Bcells_Human0.90691545
147EGR1_19032775_ChIP-ChIP_M12_Human0.88526800
148GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86610403
149* FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.83503684
150SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.83009211
151VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.79855429
152VDR_21846776_ChIP-Seq_THP-1_Human0.77975376
153TFEB_21752829_ChIP-Seq_HELA_Human0.77063795
154THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.77045107
155BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.74877446
156MAF_26560356_Chip-Seq_TH2_Human0.73572558
157ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.71024519
158PU.1_20513432_ChIP-Seq_Bcells_Mouse0.70346520
159KDM2B_26808549_Chip-Seq_SUP-B15_Human0.70097567
160GATA1_19941827_ChIP-Seq_MEL86_Mouse0.69573953
161RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.66986541
162SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.65981438
163GATA1_19941826_ChIP-Seq_K562_Human0.65762958
164CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.64912072
165GATA2_19941826_ChIP-Seq_K562_Human0.63267704
166KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.63016456
167STAT1_20625510_ChIP-Seq_HELA_Human0.62701474
168KDM2B_26808549_Chip-Seq_DND41_Human0.59544344
169LXR_22158963_ChIP-Seq_LIVER_Mouse0.59260879
170PRDM14_20953172_ChIP-Seq_ESCs_Human0.57286804
171TCF7_22412390_ChIP-Seq_EML_Mouse0.55762287
172STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.55739773
173GATA3_26560356_Chip-Seq_TH1_Human0.54012785
174SALL4_22934838_ChIP-ChIP_CD34+_Human0.53717443
175EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.52385847

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.69991260
2MP0003880_abnormal_central_pattern3.55303836
3MP0001835_abnormal_antigen_presentation3.12490131
4MP0001968_abnormal_touch/_nociception2.77011645
5MP0009046_muscle_twitch2.67049895
6MP0002735_abnormal_chemical_nociception2.60061273
7MP0001501_abnormal_sleep_pattern2.58715157
8MP0009785_altered_susceptibility_to2.53552279
9MP0004858_abnormal_nervous_system2.50606270
10MP0003635_abnormal_synaptic_transmissio2.49004903
11MP0009745_abnormal_behavioral_response2.44608026
12MP0002736_abnormal_nociception_after2.37968435
13MP0002148_abnormal_hypersensitivity_rea2.35747482
14MP0002064_seizures2.33886923
15MP0003191_abnormal_cellular_cholesterol2.31031563
16MP0002063_abnormal_learning/memory/cond2.18943615
17MP0002876_abnormal_thyroid_physiology2.14244061
18MP0003690_abnormal_glial_cell2.11508789
19MP0000569_abnormal_digit_pigmentation2.11442405
20MP0005058_abnormal_lysosome_morphology2.07807612
21MP0006082_CNS_inflammation2.06460539
22MP0002572_abnormal_emotion/affect_behav2.04153124
23MP0003183_abnormal_peptide_metabolism2.03808280
24MP0004270_analgesia2.00312387
25MP0004510_myositis1.98311661
26MP0002734_abnormal_mechanical_nocicepti1.98149383
27MP0002733_abnormal_thermal_nociception1.96894935
28MP0003300_gastrointestinal_ulcer1.91147665
29MP0002419_abnormal_innate_immunity1.87163409
30MP0003436_decreased_susceptibility_to1.85398062
31MP0002822_catalepsy1.83977875
32MP0005671_abnormal_response_to1.81774464
33MP0005025_abnormal_response_to1.79312246
34MP0005000_abnormal_immune_tolerance1.78439838
35MP0006276_abnormal_autonomic_nervous1.78176527
36MP0006292_abnormal_olfactory_placode1.75336378
37MP0001970_abnormal_pain_threshold1.75151805
38MP0003195_calcinosis1.71402261
39MP0001440_abnormal_grooming_behavior1.69370312
40MP0002139_abnormal_hepatobiliary_system1.64937054
41MP0003172_abnormal_lysosome_physiology1.64229916
42MP0003724_increased_susceptibility_to1.63477671
43MP0002254_reproductive_system_inflammat1.62035521
44MP0002272_abnormal_nervous_system1.61015516
45MP0010386_abnormal_urinary_bladder1.60510308
46MP0002277_abnormal_respiratory_mucosa1.59633903
47MP0005387_immune_system_phenotype1.58668934
48MP0001790_abnormal_immune_system1.58668934
49MP0002405_respiratory_system_inflammati1.56139514
50MP0001188_hyperpigmentation1.53557454
51MP0005423_abnormal_somatic_nervous1.47046305
52MP0003787_abnormal_imprinting1.46504600
53MP0002332_abnormal_exercise_endurance1.45787002
54MP0004947_skin_inflammation1.42900792
55MP0002723_abnormal_immune_serum1.42859612
56MP0001486_abnormal_startle_reflex1.40664985
57MP0002067_abnormal_sensory_capabilities1.40573605
58MP0002452_abnormal_antigen_presenting1.40145500
59MP0010155_abnormal_intestine_physiology1.35947917
60MP0009278_abnormal_bone_marrow1.34941852
61MP0005451_abnormal_body_composition1.34250951
62MP0005310_abnormal_salivary_gland1.33736646
63MP0003075_altered_response_to1.33656256
64MP0001800_abnormal_humoral_immune1.31063859
65MP0009333_abnormal_splenocyte_physiolog1.30330090
66MP0003011_delayed_dark_adaptation1.28237610
67MP0002398_abnormal_bone_marrow1.27470766
68MP0005166_decreased_susceptibility_to1.27135556
69MP0001819_abnormal_immune_cell1.27008122
70MP0009840_abnormal_foam_cell1.26407195
71MP0005464_abnormal_platelet_physiology1.26165971
72MP0001545_abnormal_hematopoietic_system1.25996926
73MP0005397_hematopoietic_system_phenotyp1.25996926
74MP0004924_abnormal_behavior1.25221250
75MP0005386_behavior/neurological_phenoty1.25221250
76MP0005646_abnormal_pituitary_gland1.24980311
77MP0009764_decreased_sensitivity_to1.24792252
78MP0000920_abnormal_myelination1.24443756
79MP0001986_abnormal_taste_sensitivity1.24274115
80MP0002420_abnormal_adaptive_immunity1.22844957
81MP0005535_abnormal_body_temperature1.21853827
82MP0002998_abnormal_bone_remodeling1.19752717
83MP0003329_amyloid_beta_deposits1.17244476
84MP0005174_abnormal_tail_pigmentation1.16980783
85MP0005075_abnormal_melanosome_morpholog1.15623840
86MP0004142_abnormal_muscle_tone1.14293180
87MP0001905_abnormal_dopamine_level1.13437324
88MP0003303_peritoneal_inflammation1.12373105
89MP0001984_abnormal_olfaction1.11943574
90MP0000015_abnormal_ear_pigmentation1.11075935
91MP0004883_abnormal_blood_vessel1.10643915
92MP0003806_abnormal_nucleotide_metabolis1.08410924
93MP0000689_abnormal_spleen_morphology1.07932821
94MP0000685_abnormal_immune_system1.07103971
95MP0003656_abnormal_erythrocyte_physiolo1.06655635
96MP0005645_abnormal_hypothalamus_physiol1.05634557
97MP0003879_abnormal_hair_cell1.04841232
98MP0002429_abnormal_blood_cell1.04639537
99MP0005164_abnormal_response_to1.04497334
100MP0002638_abnormal_pupillary_reflex1.03003329
101MP0004811_abnormal_neuron_physiology1.01328761
102MP0003633_abnormal_nervous_system1.01195408
103MP0000858_altered_metastatic_potential1.00788104
104MP0002090_abnormal_vision0.99110168
105MP0008874_decreased_physiological_sensi0.98679212
106MP0002184_abnormal_innervation0.98430135
107MP0008004_abnormal_stomach_pH0.97438191
108MP0002722_abnormal_immune_system0.97411095
109MP0009763_increased_sensitivity_to0.96875151
110MP0001845_abnormal_inflammatory_respons0.93840882
111MP0003866_abnormal_defecation0.93354010
112MP0006035_abnormal_mitochondrial_morpho0.92560052
113MP0003828_pulmonary_edema0.92365039
114MP0003122_maternal_imprinting0.92126957
115MP0000465_gastrointestinal_hemorrhage0.91575366
116MP0001853_heart_inflammation0.89285495
117MP0008872_abnormal_physiological_respon0.88777300
118MP0005167_abnormal_blood-brain_barrier0.88250115
119MP0002557_abnormal_social/conspecific_i0.88090744
120MP0008260_abnormal_autophagy0.85062755
121MP0009765_abnormal_xenobiotic_induced0.84331516
122MP0002132_abnormal_respiratory_system0.83526512
123MP0000372_irregular_coat_pigmentation0.83224140
124MP0008469_abnormal_protein_level0.82979014
125MP0000343_altered_response_to0.81598834
126MP0000604_amyloidosis0.80944507
127MP0002138_abnormal_hepatobiliary_system0.80315912
128MP0002006_tumorigenesis0.80197323
129MP0000716_abnormal_immune_system0.80056052
130MP0001529_abnormal_vocalization0.80028159
131MP0004782_abnormal_surfactant_physiolog0.79753459
132MP0003763_abnormal_thymus_physiology0.79185066
133MP0001851_eye_inflammation0.78374809
134MP0002909_abnormal_adrenal_gland0.77460631
135MP0003448_altered_tumor_morphology0.77138381
136MP0001533_abnormal_skeleton_physiology0.73551145
137MP0003631_nervous_system_phenotype0.73334952
138MP0008569_lethality_at_weaning0.73327946
139MP0002166_altered_tumor_susceptibility0.66715515
140MP0000371_diluted_coat_color0.66347454
141MP0002693_abnormal_pancreas_physiology0.65017341
142MP0004381_abnormal_hair_follicle0.56061032
143MP0005584_abnormal_enzyme/coenzyme_acti0.55925419

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.52125382
2Febrile seizures (HP:0002373)4.90160546
3Recurrent abscess formation (HP:0002722)4.83116488
4Recurrent bacterial skin infections (HP:0005406)4.54215689
5Eczematoid dermatitis (HP:0000976)4.12814847
6Recurrent gram-negative bacterial infections (HP:0005420)3.98897020
7Epileptic encephalopathy (HP:0200134)3.90834875
8Hypothermia (HP:0002045)3.72045143
9Increased IgM level (HP:0003496)3.69790140
10Atonic seizures (HP:0010819)3.69530004
11Hyperventilation (HP:0002883)3.63127475
12Focal seizures (HP:0007359)3.58245927
13Keratoconjunctivitis sicca (HP:0001097)3.49735105
14Mediastinal lymphadenopathy (HP:0100721)3.47898046
15Myokymia (HP:0002411)3.45633228
16Gastrointestinal infarctions (HP:0005244)3.36936289
17Elevated erythrocyte sedimentation rate (HP:0003565)3.35338087
18Dialeptic seizures (HP:0011146)3.23012875
19Keratoconjunctivitis (HP:0001096)3.22614769
20Abnormal hair whorl (HP:0010721)3.22155875
21Gingivitis (HP:0000230)3.19493995
22Disinhibition (HP:0000734)3.19110181
23Systemic lupus erythematosus (HP:0002725)3.15257213
24Absence seizures (HP:0002121)3.12387749
25Orchitis (HP:0100796)3.10236034
26Myositis (HP:0100614)3.07803891
27Generalized tonic-clonic seizures (HP:0002069)3.06873906
28Loss of speech (HP:0002371)3.04862661
29Visual hallucinations (HP:0002367)2.97350018
30Abnormality of macrophages (HP:0004311)2.93893449
31Progressive cerebellar ataxia (HP:0002073)2.91386794
32Hemoptysis (HP:0002105)2.90154985
33Prostate neoplasm (HP:0100787)2.89110064
34Optic neuritis (HP:0100653)2.86400669
35Retrobulbar optic neuritis (HP:0100654)2.86400669
36T lymphocytopenia (HP:0005403)2.85822807
37Encephalitis (HP:0002383)2.80190910
38Amyloidosis (HP:0011034)2.80115444
39Dysostosis multiplex (HP:0000943)2.79476088
40Stomatitis (HP:0010280)2.77431303
41Abnormality of T cell number (HP:0011839)2.72545454
42Gangrene (HP:0100758)2.64145211
43Abnormality of liposaccharide metabolism (HP:0010968)2.62831318
44Abnormality of glycosphingolipid metabolism (HP:0004343)2.62831318
45Abnormality of glycolipid metabolism (HP:0010969)2.62831318
46Inability to walk (HP:0002540)2.61394949
47Protruding tongue (HP:0010808)2.61214426
48Recurrent skin infections (HP:0001581)2.59591622
49Neurofibrillary tangles (HP:0002185)2.52021496
50Arterial thrombosis (HP:0004420)2.49300677
51Neuronal loss in central nervous system (HP:0002529)2.47410067
52Progressive neurologic deterioration (HP:0002344)2.42524529
53Inappropriate behavior (HP:0000719)2.42494922
54Vasculitis (HP:0002633)2.41774527
55Chronic obstructive pulmonary disease (HP:0006510)2.41366616
56Obstructive lung disease (HP:0006536)2.41366616
57Episodic fever (HP:0001954)2.40486687
58Pulmonary embolism (HP:0002204)2.39442265
59Recurrent fungal infections (HP:0002841)2.38397001
60Amblyopia (HP:0000646)2.37944835
61Progressive inability to walk (HP:0002505)2.35561705
62Reduced antithrombin III activity (HP:0001976)2.35300247
63Abnormality of polysaccharide metabolism (HP:0011012)2.34692447
64Abnormality of glycosaminoglycan metabolism (HP:0004371)2.34692447
65Abnormality of mucopolysaccharide metabolism (HP:0011020)2.34692447
66Diminished motivation (HP:0000745)2.33979658
67Memory impairment (HP:0002354)2.32611078
68Apathy (HP:0000741)2.30901063
69Increased neuronal autofluorescent lipopigment (HP:0002074)2.30341029
70Anorexia (HP:0002039)2.27726877
71Autoimmune thrombocytopenia (HP:0001973)2.27615482
72Hypochromic microcytic anemia (HP:0004840)2.26337057
73Urinary glycosaminoglycan excretion (HP:0003541)2.25857577
74Mucopolysacchariduria (HP:0008155)2.25857577
75Gingival bleeding (HP:0000225)2.25670255
76Failure to thrive in infancy (HP:0001531)2.24746818
77Increased cerebral lipofuscin (HP:0011813)2.22886210
78Leukocytosis (HP:0001974)2.22173032
79Absent speech (HP:0001344)2.21192062
80Chest pain (HP:0100749)2.20187509
81Horizontal nystagmus (HP:0000666)2.18950023
82Absent frontal sinuses (HP:0002688)2.18903599
83Pulmonary infiltrates (HP:0002113)2.16285807
84Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.15719817
85Hypoplasia of the fovea (HP:0007750)2.15540559
86Aplasia/Hypoplasia of the fovea (HP:0008060)2.15540559
87Vertigo (HP:0002321)2.13808717
88Myocardial infarction (HP:0001658)2.12430329
89Tetraparesis (HP:0002273)2.12132784
90Abnormality of the pleura (HP:0002103)2.11706419
91Purpura (HP:0000979)2.11050982
92Abnormal delayed hypersensitivity skin test (HP:0002963)2.08440346
93Supranuclear gaze palsy (HP:0000605)2.07022302
94Generalized hypopigmentation (HP:0007513)2.06420808
95Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.06049503
96Recurrent cutaneous fungal infections (HP:0011370)2.05932136
97Chronic mucocutaneous candidiasis (HP:0002728)2.05932136
98Joint swelling (HP:0001386)2.05164628
99Autoimmune hemolytic anemia (HP:0001890)2.04686706
100Polyphagia (HP:0002591)2.04624193
101Hypokinesia (HP:0002375)2.03828170
102Increased serum ferritin (HP:0003281)2.03511356
103Upper motor neuron abnormality (HP:0002127)2.02874307
104Gait imbalance (HP:0002141)2.02119294
105Hepatosplenomegaly (HP:0001433)2.02000533
106Bilateral microphthalmos (HP:0007633)2.01530225
107Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.01398112
108Excessive salivation (HP:0003781)2.00059688
109Drooling (HP:0002307)2.00059688
110Cellulitis (HP:0100658)1.99537284
111Polyneuropathy (HP:0001271)1.99110550
112Gaze-evoked nystagmus (HP:0000640)1.96383340
113Increased IgE level (HP:0003212)1.96156809
114Interstitial pulmonary disease (HP:0006530)1.94018863
115Amaurosis fugax (HP:0100576)1.93328824
116Hematochezia (HP:0002573)1.93117815
117Osteomyelitis (HP:0002754)1.91569612
118Slow saccadic eye movements (HP:0000514)1.91015046
119Generalized hypopigmentation of hair (HP:0011358)1.90180772
120Chronic otitis media (HP:0000389)1.89326882
121Glomerulonephritis (HP:0000099)1.88722445
122Cerebral inclusion bodies (HP:0100314)1.87905655
123Hypergammaglobulinemia (HP:0010702)1.87831794
124Abnormality of the endocardium (HP:0004306)1.87272478
125Glomerulopathy (HP:0100820)1.85730680
126Abnormality of the prostate (HP:0008775)1.85126196
127Spontaneous hematomas (HP:0007420)1.83843166
128Limb dystonia (HP:0002451)1.83675582
129Congenital primary aphakia (HP:0007707)1.83093879
130Abnormality of the periventricular white matter (HP:0002518)1.80842980
131Abnormality of T cells (HP:0002843)1.79590495
132Recurrent viral infections (HP:0004429)1.78805889
133Periodontitis (HP:0000704)1.78233781
134Abnormality of the fovea (HP:0000493)1.77934819
135Agnosia (HP:0010524)1.77868591
136Dyschromatopsia (HP:0007641)1.76992754
137Medial flaring of the eyebrow (HP:0010747)1.76093592
138Nephrogenic diabetes insipidus (HP:0009806)1.76024417
139Iris hypopigmentation (HP:0007730)1.75949065
140Hemiparesis (HP:0001269)1.75771368
141Vacuolated lymphocytes (HP:0001922)1.75322660
142Basal ganglia calcification (HP:0002135)1.74689390
143Urticaria (HP:0001025)1.74624133
144Diplopia (HP:0000651)1.74020376
145Abnormality of binocular vision (HP:0011514)1.74020376
146Broad-based gait (HP:0002136)1.73800831
147Bradykinesia (HP:0002067)1.73154122
148Fair hair (HP:0002286)1.72431889
149Oligomenorrhea (HP:0000876)1.72289023
150Type I transferrin isoform profile (HP:0003642)1.72027971
151Exotropia (HP:0000577)1.71482457
152Mutism (HP:0002300)1.70729208
153Meningitis (HP:0001287)1.70656317
154Chromosomal breakage induced by crosslinking agents (HP:0003221)1.70374791
155Status epilepticus (HP:0002133)1.69996363
156Spastic tetraparesis (HP:0001285)1.68858577
157Abnormal eating behavior (HP:0100738)1.67822845
158Papilledema (HP:0001085)1.67072860
159Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.66051112

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.33930354
2MAP3K123.99124553
3GRK53.40183666
4NTRK33.04428308
5CASK2.65376151
6MAP2K72.47854008
7MAP3K142.47470935
8MAP4K12.23547557
9ADRBK22.22477071
10SIK32.10002644
11MAP2K42.04174344
12GRK72.02607926
13MAP3K92.02052752
14EPHA41.94449954
15MAP3K131.93657775
16PLK21.93479871
17DAPK21.92683103
18MATK1.89190739
19BMPR21.87019585
20MAP3K41.82490563
21DAPK11.79419145
22CAMKK21.63368473
23TAOK31.62124170
24KIT1.59314291
25MINK11.57879403
26MAP3K111.57568224
27PRPF4B1.50174116
28IRAK41.48561181
29TNIK1.46005344
30BLK1.43765818
31MAP2K31.43286051
32TBK11.42484286
33CDK121.34690074
34TAOK11.34061587
35ARAF1.27152469
36NTRK11.25036714
37IRAK21.24368433
38TXK1.21282084
39AKT31.18049299
40GRK61.16775033
41MAP3K21.16223367
42CSF1R1.14860670
43IRAK11.13611982
44SYK1.13359907
45IKBKE1.11492326
46FES1.09528551
47MAP3K61.06524416
48YES11.06265142
49MARK11.05391043
50BTK1.03195424
51IKBKB1.02426415
52GRK11.02376946
53MAP3K30.95552333
54CAMKK10.93197090
55SIK20.91519991
56PBK0.91239509
57ADRBK10.89255214
58JAK30.88695495
59KSR20.86455340
60BMPR1B0.85971057
61FGR0.83144757
62EIF2AK20.79164686
63ITK0.78876380
64IRAK30.77354472
65TYK20.77124337
66JAK10.76775075
67TNK20.74978875
68KSR10.73197649
69PRKCG0.71857036
70SGK20.71412072
71ERN10.71385842
72MAPK130.68564787
73MAP3K50.68265486
74CAMK40.67964591
75DDR20.65873360
76FYN0.65575650
77MOS0.65503158
78CDK190.65458666
79PDPK10.63642003
80ACVR1B0.63299986
81LYN0.61314993
82FGFR30.60453063
83CDK50.58550421
84EPHB10.58029098
85MARK30.56792630
86MAPK70.56738679
87PRKCD0.56705091
88PRKCE0.54478312
89FGFR40.52911575
90HCK0.51284930
91PRKCQ0.51207723
92ALK0.50790763
93ABL20.48972577
94CCNB10.48471013
95MAPK120.47819837
96RIPK10.47432612
97PDK10.46756248
98ERBB30.46670838
99MAP3K10.46508434
100MAP2K60.46319476
101CAMK2A0.45898068
102NTRK20.44855032
103LCK0.44787374
104CDC42BPA0.41263236
105ABL10.41187041
106NME20.40282488
107CHUK0.38716511
108EPHA30.38226031
109PRKG20.38151853
110RAF10.37739569
111SGK10.36656271
112PIM20.35738529
113MARK20.34750255
114SGK30.34141758
115TEC0.32175978
116CAMK10.31975576
117ZAP700.31873291
118BRD40.30562028
119OXSR10.30064484
120JAK20.29122251
121RPS6KA20.28553749
122CSK0.27878255
123TAOK20.26245276
124STK110.25758832
125TRIM280.25660283
126PAK60.25185033
127MAPK40.24526908
128PINK10.24308284
129TGFBR20.24218799
130EGFR0.24195017
131CDK140.23685178

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.11333652
2Nicotine addiction_Homo sapiens_hsa050332.93289137
3Collecting duct acid secretion_Homo sapiens_hsa049662.80857774
4Rheumatoid arthritis_Homo sapiens_hsa053232.25859590
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.24419120
6Olfactory transduction_Homo sapiens_hsa047402.09844688
7Type I diabetes mellitus_Homo sapiens_hsa049402.06077662
8African trypanosomiasis_Homo sapiens_hsa051431.98848090
9Leishmaniasis_Homo sapiens_hsa051401.95815300
10Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.90687356
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.90542423
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.88949489
13Graft-versus-host disease_Homo sapiens_hsa053321.88625151
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.85805577
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.82829486
16Morphine addiction_Homo sapiens_hsa050321.77476457
17GABAergic synapse_Homo sapiens_hsa047271.76906965
18Long-term potentiation_Homo sapiens_hsa047201.67195359
19Tuberculosis_Homo sapiens_hsa051521.66921889
20Antigen processing and presentation_Homo sapiens_hsa046121.65310429
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.64579325
22Allograft rejection_Homo sapiens_hsa053301.62366711
23Glutamatergic synapse_Homo sapiens_hsa047241.59579053
24Phagosome_Homo sapiens_hsa041451.57861743
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.57371608
26Taste transduction_Homo sapiens_hsa047421.53775926
27Serotonergic synapse_Homo sapiens_hsa047261.52688556
28Circadian entrainment_Homo sapiens_hsa047131.49059395
29Legionellosis_Homo sapiens_hsa051341.48378226
30Pertussis_Homo sapiens_hsa051331.46599555
31Other glycan degradation_Homo sapiens_hsa005111.42498538
32Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.35882251
33Amphetamine addiction_Homo sapiens_hsa050311.35485063
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32125285
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.31106298
36Vibrio cholerae infection_Homo sapiens_hsa051101.30272114
37Dopaminergic synapse_Homo sapiens_hsa047281.29837559
38Osteoclast differentiation_Homo sapiens_hsa043801.29075318
39Staphylococcus aureus infection_Homo sapiens_hsa051501.23639175
40Influenza A_Homo sapiens_hsa051641.22533621
41Salivary secretion_Homo sapiens_hsa049701.21867381
42Calcium signaling pathway_Homo sapiens_hsa040201.19293206
43TNF signaling pathway_Homo sapiens_hsa046681.17942767
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.16821516
45Salmonella infection_Homo sapiens_hsa051321.15885051
46Asthma_Homo sapiens_hsa053101.15857870
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.15193209
48Viral myocarditis_Homo sapiens_hsa054161.15157798
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.14754852
50Primary immunodeficiency_Homo sapiens_hsa053401.14184760
51Glycosaminoglycan degradation_Homo sapiens_hsa005311.13942312
52SNARE interactions in vesicular transport_Homo sapiens_hsa041301.13737386
53Cholinergic synapse_Homo sapiens_hsa047251.12750239
54Phototransduction_Homo sapiens_hsa047441.10841516
55Chemokine signaling pathway_Homo sapiens_hsa040621.09340906
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08264294
57Renin secretion_Homo sapiens_hsa049241.08241830
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.03461322
59Long-term depression_Homo sapiens_hsa047301.03127598
60Measles_Homo sapiens_hsa051621.00910610
61T cell receptor signaling pathway_Homo sapiens_hsa046600.99310344
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93153893
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.85518935
64Type II diabetes mellitus_Homo sapiens_hsa049300.84332008
65GnRH signaling pathway_Homo sapiens_hsa049120.84299254
66Oxytocin signaling pathway_Homo sapiens_hsa049210.82190423
67Insulin secretion_Homo sapiens_hsa049110.79517174
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79302228
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.78904874
70Malaria_Homo sapiens_hsa051440.78691781
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.78554143
72B cell receptor signaling pathway_Homo sapiens_hsa046620.78146815
73Lysosome_Homo sapiens_hsa041420.76792050
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75627164
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72921282
76Cocaine addiction_Homo sapiens_hsa050300.65739991
77Shigellosis_Homo sapiens_hsa051310.63893720
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63177204
79Autoimmune thyroid disease_Homo sapiens_hsa053200.62064016
80Hematopoietic cell lineage_Homo sapiens_hsa046400.60396010
81Gastric acid secretion_Homo sapiens_hsa049710.60265520
82Oxidative phosphorylation_Homo sapiens_hsa001900.60211760
83Hepatitis C_Homo sapiens_hsa051600.59897828
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59141023
85cAMP signaling pathway_Homo sapiens_hsa040240.58939980
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58576119
87Dorso-ventral axis formation_Homo sapiens_hsa043200.57337508
88Platelet activation_Homo sapiens_hsa046110.57095573
89Acute myeloid leukemia_Homo sapiens_hsa052210.57079715
90Herpes simplex infection_Homo sapiens_hsa051680.53965468
91Toxoplasmosis_Homo sapiens_hsa051450.53024670
92Regulation of autophagy_Homo sapiens_hsa041400.52846098
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.52502137
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.51831470
95Fructose and mannose metabolism_Homo sapiens_hsa000510.51009076
96Inositol phosphate metabolism_Homo sapiens_hsa005620.48535723
97VEGF signaling pathway_Homo sapiens_hsa043700.48085198
98Prolactin signaling pathway_Homo sapiens_hsa049170.47972409
99MAPK signaling pathway_Homo sapiens_hsa040100.47793669
100Glioma_Homo sapiens_hsa052140.47321954
101ErbB signaling pathway_Homo sapiens_hsa040120.47110250
102Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47053687
103Hepatitis B_Homo sapiens_hsa051610.46319604
104Epstein-Barr virus infection_Homo sapiens_hsa051690.45834060
105Prion diseases_Homo sapiens_hsa050200.45661098
106Complement and coagulation cascades_Homo sapiens_hsa046100.44821300
107Alzheimers disease_Homo sapiens_hsa050100.43129532
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41237988
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40735749
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.40607609
111AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40375023
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.39035125
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38962173
114Renal cell carcinoma_Homo sapiens_hsa052110.37767827
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37713172
116mTOR signaling pathway_Homo sapiens_hsa041500.37706307
117Amoebiasis_Homo sapiens_hsa051460.37613275
118Apoptosis_Homo sapiens_hsa042100.37538821
119Jak-STAT signaling pathway_Homo sapiens_hsa046300.35245813
120Ras signaling pathway_Homo sapiens_hsa040140.35111142
121HIF-1 signaling pathway_Homo sapiens_hsa040660.35032517
122Endocytosis_Homo sapiens_hsa041440.33113709
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32147472
124Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29614287
125Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.25934608
126Non-small cell lung cancer_Homo sapiens_hsa052230.25114588
127Pancreatic cancer_Homo sapiens_hsa052120.23985230
128Mineral absorption_Homo sapiens_hsa049780.22640589
129Sphingolipid metabolism_Homo sapiens_hsa006000.21945834
130Estrogen signaling pathway_Homo sapiens_hsa049150.20540142

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