SNX11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene encodes a protein of unknown function. This gene results in two transcript variants differing in the 5' UTR, but encoding the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)9.69599642
2doxorubicin metabolic process (GO:0044598)9.69599642
3daunorubicin metabolic process (GO:0044597)9.69599642
4maintenance of protein location in nucleus (GO:0051457)6.57298555
5somite rostral/caudal axis specification (GO:0032525)6.20342905
6protein localization to kinetochore (GO:0034501)6.16747999
7regulation of mammary gland epithelial cell proliferation (GO:0033599)6.00360509
8aminoglycoside antibiotic metabolic process (GO:0030647)5.99008179
9negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.82279151
10regulation of telomere maintenance via telomerase (GO:0032210)5.73164711
11regulation of response to osmotic stress (GO:0047484)5.65862681
12negative regulation of epidermis development (GO:0045683)5.60922441
13histone H4-K8 acetylation (GO:0043982)5.60752514
14histone H4-K5 acetylation (GO:0043981)5.60752514
15regulation of MHC class I biosynthetic process (GO:0045343)5.49863279
16positive regulation by symbiont of host defense response (GO:0052509)5.49151487
17modulation by symbiont of host defense response (GO:0052031)5.49151487
18modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.49151487
19modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.49151487
20positive regulation by organism of defense response of other organism involved in symbiotic interact5.49151487
21modulation by symbiont of host immune response (GO:0052553)5.49151487
22negative regulation of telomerase activity (GO:0051974)5.48674820
23negative regulation of cell killing (GO:0031342)5.45571393
24negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.45571393
25muscle organ morphogenesis (GO:0048644)5.29199353
26histone H4-K12 acetylation (GO:0043983)5.21461638
27regulation of nuclear cell cycle DNA replication (GO:0033262)5.14961340
28positive regulation of gamma-delta T cell activation (GO:0046645)5.11990233
29negative regulation of cell cycle G2/M phase transition (GO:1902750)5.09799562
30rRNA transcription (GO:0009303)4.90225751
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.89299767
32regulation of B cell receptor signaling pathway (GO:0050855)4.78031563
33notochord development (GO:0030903)4.77834733
34regulation of interferon-beta biosynthetic process (GO:0045357)4.77253310
35mitotic sister chromatid segregation (GO:0000070)4.75666352
36antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.71955335
37antigen processing and presentation of endogenous antigen (GO:0019883)4.64296065
38regulation of translation in response to stress (GO:0043555)4.63582404
39cytidine deamination (GO:0009972)4.62280676
40cytidine metabolic process (GO:0046087)4.62280676
41cytidine catabolic process (GO:0006216)4.62280676
42protein localization to chromosome, centromeric region (GO:0071459)4.58490401
43heterochromatin organization (GO:0070828)4.52905613
44negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.44551614
45negative regulation of interleukin-12 production (GO:0032695)4.44452326
46detection of other organism (GO:0098543)4.43095863
47response to peptidoglycan (GO:0032494)4.42314173
48immunoglobulin mediated immune response (GO:0016064)4.41125795
49antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.37133019
50detection of bacterium (GO:0016045)4.36075582
51macrophage activation involved in immune response (GO:0002281)4.27579309
52interferon-gamma production (GO:0032609)4.26092796
53neutrophil activation involved in immune response (GO:0002283)4.22751678
54negative regulation of epidermal cell differentiation (GO:0045605)4.21935909
55histone H4-K16 acetylation (GO:0043984)4.18890066
56positive regulation of DNA-dependent DNA replication (GO:2000105)4.15494845
57nuclear pore complex assembly (GO:0051292)4.12987548
58hormone catabolic process (GO:0042447)4.03649693
59regulation of apoptotic process involved in morphogenesis (GO:1902337)4.01487340
60negative regulation of telomere maintenance (GO:0032205)4.01008904
61response to dietary excess (GO:0002021)4.00541778
62regulation of cilium movement (GO:0003352)4.00280214
63rRNA methylation (GO:0031167)3.97188178
64sister chromatid segregation (GO:0000819)3.96235839
65proline transport (GO:0015824)3.94436873
66chromatin assembly (GO:0031497)3.93059322
67cellular response to type I interferon (GO:0071357)3.85351008
68type I interferon signaling pathway (GO:0060337)3.85351008
69cellular response to interleukin-15 (GO:0071350)3.84869577
70response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.82314703
71response to host immune response (GO:0052572)3.82314703
72response to type I interferon (GO:0034340)3.79673162
73mitochondrion distribution (GO:0048311)3.78557615
74respiratory burst (GO:0045730)3.76478586
75negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.76279245
76DNA replication-dependent nucleosome organization (GO:0034723)3.75815395
77DNA replication-dependent nucleosome assembly (GO:0006335)3.75815395
78pre-miRNA processing (GO:0031054)3.75515274
79maintenance of protein localization in organelle (GO:0072595)3.74612603
80intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.74562688
81branching involved in mammary gland duct morphogenesis (GO:0060444)3.73469009
82positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.71014752
83positive regulation of protein deacetylation (GO:0090312)3.68950003
84positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.68065372
85primitive streak formation (GO:0090009)3.66424898
86nucleoside transmembrane transport (GO:1901642)3.65990221
87detection of external biotic stimulus (GO:0098581)3.65211237
88DNA replication checkpoint (GO:0000076)3.62657521
89rRNA modification (GO:0000154)3.60418871
90phenol-containing compound catabolic process (GO:0019336)3.60404387
91interferon-gamma-mediated signaling pathway (GO:0060333)3.59853179
92response to interleukin-15 (GO:0070672)3.58696758
93positive regulation of histone deacetylation (GO:0031065)3.57551297
94NIK/NF-kappaB signaling (GO:0038061)3.57527127
95leukocyte aggregation (GO:0070486)3.57085142
96positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.55294421
97cell fate commitment involved in formation of primary germ layer (GO:0060795)3.54272315
98positive regulation of interferon-alpha production (GO:0032727)3.52494277
99neutrophil activation (GO:0042119)3.52280882
100microtubule severing (GO:0051013)3.51520311
101tachykinin receptor signaling pathway (GO:0007217)3.50909528
102bone trabecula formation (GO:0060346)3.50539599
103regulation of natural killer cell mediated immunity (GO:0002715)3.50515514
104regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.50515514
105T cell migration (GO:0072678)3.49654823
106mitotic chromosome condensation (GO:0007076)3.47616509
107negative regulation of lymphocyte mediated immunity (GO:0002707)3.46690020
108regulation of interferon-alpha production (GO:0032647)3.45874988
109retinoic acid receptor signaling pathway (GO:0048384)3.45776505
110B cell mediated immunity (GO:0019724)3.45385354
111regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.45181507
112cellular extravasation (GO:0045123)3.41892357
113nuclear pore organization (GO:0006999)3.40106257
114regulation of gamma-delta T cell activation (GO:0046643)3.39827362
115pyrimidine ribonucleoside catabolic process (GO:0046133)3.39473553
116response to muramyl dipeptide (GO:0032495)3.38082326
117granulocyte activation (GO:0036230)3.36994056
118B cell receptor signaling pathway (GO:0050853)3.36177027
119negative regulation of T cell mediated immunity (GO:0002710)3.33389140
120response to host (GO:0075136)3.32458295
121response to host defenses (GO:0052200)3.32458295
122response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.32458295
123detection of biotic stimulus (GO:0009595)3.31311036
124regulation of hippo signaling (GO:0035330)3.29977386
125detection of molecule of bacterial origin (GO:0032490)3.29947477
126mRNA stabilization (GO:0048255)3.29568139
127RNA stabilization (GO:0043489)3.29568139
128positive regulation of mast cell activation (GO:0033005)3.29084765
129intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.27548418
130detection of temperature stimulus (GO:0016048)3.27234022
131myeloid cell activation involved in immune response (GO:0002275)3.25464193
132regulation of mast cell degranulation (GO:0043304)3.25252592
133microglial cell activation (GO:0001774)3.24481210
134defense response to protozoan (GO:0042832)3.24218195
135negative regulation of viral release from host cell (GO:1902187)3.23163546
136regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.19632843
137regulation of telomerase activity (GO:0051972)3.19422998
138regulation of B cell differentiation (GO:0045577)3.17760916
139protein polyglutamylation (GO:0018095)3.16466290
140negative regulation of leukocyte mediated immunity (GO:0002704)3.15633179
141hypotonic response (GO:0006971)3.15437842
142coenzyme catabolic process (GO:0009109)3.14441119
143intestinal epithelial cell development (GO:0060576)3.13755364
144icosanoid secretion (GO:0032309)3.12703251
145arachidonic acid secretion (GO:0050482)3.12703251
146quinone metabolic process (GO:1901661)3.12254960
147NLS-bearing protein import into nucleus (GO:0006607)3.10513196
148regulation of mast cell activation (GO:0033003)3.09012298
149regulation of dendritic cell antigen processing and presentation (GO:0002604)3.08805187
150regulation of telomere maintenance (GO:0032204)3.08689457
151myeloid dendritic cell differentiation (GO:0043011)3.07406277
152regulation of antigen processing and presentation (GO:0002577)3.06855406
153establishment of endothelial barrier (GO:0061028)3.06599416
154negative regulation of innate immune response (GO:0045824)3.06239702
155lipopolysaccharide-mediated signaling pathway (GO:0031663)3.06081383
156germinal center formation (GO:0002467)3.05612648
157vitamin A metabolic process (GO:0006776)3.04685977
158positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.02887606
159negative thymic T cell selection (GO:0045060)3.01824071
160positive regulation of macrophage cytokine production (GO:0060907)3.01797231
161regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.01238799
162response to protozoan (GO:0001562)3.01018455
163leukocyte migration involved in inflammatory response (GO:0002523)2.98909603
164positive regulation of antigen processing and presentation (GO:0002579)2.98741019
165negative regulation of potassium ion transmembrane transport (GO:1901380)2.98719893
166apoptotic DNA fragmentation (GO:0006309)2.98375093
167regulation of T cell mediated cytotoxicity (GO:0001914)2.97603324
168maternal placenta development (GO:0001893)2.96185115
169cullin deneddylation (GO:0010388)2.95347736
170intracellular estrogen receptor signaling pathway (GO:0030520)2.95285211
171cardiovascular system development (GO:0072358)2.94231503
172T-helper 1 type immune response (GO:0042088)2.94103583
173myeloid dendritic cell activation (GO:0001773)2.92394122
174regulation of mast cell activation involved in immune response (GO:0033006)2.91584708
175pore complex assembly (GO:0046931)2.90950207
176positive regulation of B cell differentiation (GO:0045579)2.90844677
177negative T cell selection (GO:0043383)2.89664821
178regulation of alpha-beta T cell proliferation (GO:0046640)2.89283403
179adaptation of signaling pathway (GO:0023058)2.87558300
180macrophage activation (GO:0042116)2.87053597
181trophectodermal cell differentiation (GO:0001829)2.86315665
182regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.85969382
183cellular modified amino acid catabolic process (GO:0042219)2.85268580
184regulation of interleukin-12 production (GO:0032655)2.84893843
185neutrophil mediated immunity (GO:0002446)2.84717361
186positive regulation of B cell mediated immunity (GO:0002714)2.84682008
187positive regulation of immunoglobulin mediated immune response (GO:0002891)2.84682008
188positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.84627637
189regulation of leukocyte mediated cytotoxicity (GO:0001910)2.83940763
190regulation of T cell tolerance induction (GO:0002664)2.83195395
191negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.82076767
192epoxygenase P450 pathway (GO:0019373)2.81331080
193negative regulation of interleukin-2 production (GO:0032703)2.80857708
194tolerance induction (GO:0002507)2.80311115
195positive regulation of T cell mediated cytotoxicity (GO:0001916)2.79946763
196regulation of interleukin-2 biosynthetic process (GO:0045076)2.79881300
197CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.79534541
198positive thymic T cell selection (GO:0045059)2.78489981
199B cell homeostasis (GO:0001782)2.75797029
200regulation of cell killing (GO:0031341)2.73773249

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.30067463
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.93925459
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.93925459
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.93925459
5IRF8_22096565_ChIP-ChIP_GC-B_Human5.54128533
6IRF8_21731497_ChIP-ChIP_J774_Mouse4.27281471
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.64703110
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.40664265
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.32417945
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.30959563
11E2F7_22180533_ChIP-Seq_HELA_Human3.11678559
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.09049026
13NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.99778614
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.82266776
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.79306643
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.72154424
17SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.71706492
18SPI1_23547873_ChIP-Seq_NB4_Human2.70050828
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.69677801
20SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.60564055
21SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.57535910
22* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.48459731
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.48371520
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.48146005
25POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.47599464
26NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.44614025
27STAT4_19710469_ChIP-ChIP_TH1__Mouse2.44003761
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.35666399
29MAF_26560356_Chip-Seq_TH1_Human2.31110814
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.27930619
31FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.27927589
32* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.22488544
33* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.21196803
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.20173439
35FOXM1_23109430_ChIP-Seq_U2OS_Human2.19835629
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.16739912
37VDR_24763502_ChIP-Seq_THP-1_Human2.16716109
38TCF3_18692474_ChIP-Seq_MEFs_Mouse2.15193547
39MYB_26560356_Chip-Seq_TH2_Human2.14770070
40ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.10486096
41STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.09628244
42* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.04312676
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.97061482
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.96615722
45MYC_22102868_ChIP-Seq_BL_Human1.89193438
46MAF_26560356_Chip-Seq_TH2_Human1.88461983
47* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.88276589
48UTX_26944678_Chip-Seq_JUKART_Human1.87766150
49RUNX_20019798_ChIP-Seq_JUKART_Human1.86177418
50RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.85178179
51BRD4_27068464_Chip-Seq_AML-cells_Mouse1.84801705
52ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.84398323
53MYB_26560356_Chip-Seq_TH1_Human1.81593944
54VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.80198138
55E2F4_17652178_ChIP-ChIP_JURKAT_Human1.77564206
56NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.74466666
57KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.73022299
58* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.67140962
59ZFP281_18757296_ChIP-ChIP_E14_Mouse1.66448967
60STAT3_1855785_ChIP-Seq_MESCs_Mouse1.65805472
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.65575989
62ZFP281_27345836_Chip-Seq_ESCs_Mouse1.61759916
63HIF1A_21447827_ChIP-Seq_MCF-7_Human1.61648232
64KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60579630
65CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.56806583
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.56793121
67* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.54023787
68CIITA_25753668_ChIP-Seq_RAJI_Human1.53497567
69TFEB_21752829_ChIP-Seq_HELA_Human1.53106233
70TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52945305
71TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.52415418
72SCL_19346495_ChIP-Seq_HPC-7_Human1.51684893
73* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.51227523
74LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.51024253
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.44948288
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.44569096
77TCF7_22412390_ChIP-Seq_EML_Mouse1.43166833
78EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42700795
79PU.1_20513432_ChIP-Seq_Bcells_Mouse1.41856806
80NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41823347
81Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.41772884
82FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.41217644
83GATA3_27048872_Chip-Seq_THYMUS_Human1.40835286
84* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.39805217
85SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39584400
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39461932
87FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.38720365
88CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38377369
89* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.36923784
90PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.36848155
91PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36120361
92* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.36086254
93* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34689269
94BCL6_27268052_Chip-Seq_Bcells_Human1.34555766
95JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.33801421
96GATA3_26560356_Chip-Seq_TH2_Human1.33746785
97GATA2_22383799_ChIP-Seq_G1ME_Mouse1.33334099
98* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.32212383
99MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.30818277
100* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29876336
101STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26088777
102KDM2B_26808549_Chip-Seq_K562_Human1.25520560
103ELK3_25401928_ChIP-Seq_HUVEC_Human1.25014856
104* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.23220570
105EGR1_19374776_ChIP-ChIP_THP-1_Human1.22736850
106RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21052079
107PU_27001747_Chip-Seq_BMDM_Mouse1.20824744
108CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.20646389
109TP53_22127205_ChIP-Seq_IMR90_Human1.20328407
110PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20114239
111GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18518393
112TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18381906
113E2F1_17053090_ChIP-ChIP_MCF-7_Human1.17979843
114* VDR_23849224_ChIP-Seq_CD4+_Human1.17650621
115NOTCH1_21737748_ChIP-Seq_TLL_Human1.17519345
116KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17068622
117* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14893931
118VDR_24787735_ChIP-Seq_THP-1_Human1.14390405
119* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14007890
120STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13400395
121NCOR1_26117541_ChIP-Seq_K562_Human1.12089006
122GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11904784
123OCT4_18692474_ChIP-Seq_MEFs_Mouse1.10501714
124SMC4_20622854_ChIP-Seq_HELA_Human1.09514814
125* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.07560674
126FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06710967
127TP63_17297297_ChIP-ChIP_HaCaT_Human1.06607342
128IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06404566
129ELF1_20517297_ChIP-Seq_JURKAT_Human1.06242829
130ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04000808
131LXR_22292898_ChIP-Seq_THP-1_Human1.03941427
132KDM2B_26808549_Chip-Seq_DND41_Human1.03081268
133NANOG_21062744_ChIP-ChIP_HESCs_Human1.02345190
134NANOG_16518401_ChIP-PET_MESCs_Mouse1.01516678
135GATA1_19941827_ChIP-Seq_MEL_Mouse1.01331685
136FOXP3_21729870_ChIP-Seq_TREG_Human1.00302123
137ELK4_26923725_Chip-Seq_MESODERM_Mouse0.98827028
138CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98093991
139RACK7_27058665_Chip-Seq_MCF-7_Human0.97528658
140E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.97309576
141ETS1_20019798_ChIP-Seq_JURKAT_Human0.97257030
142TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.96993443
143POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.96141080
144SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96065579
145IRF1_19129219_ChIP-ChIP_H3396_Human0.94150831
146KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94008448
147* MYC_19079543_ChIP-ChIP_MESCs_Mouse0.93825644
148EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.93168522
149P68_20966046_ChIP-Seq_HELA_Human0.92945291
150VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92293554
151GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91716847
152VDR_21846776_ChIP-Seq_THP-1_Human0.91184300
153SOX2_18692474_ChIP-Seq_MEFs_Mouse0.90864392
154GABP_17652178_ChIP-ChIP_JURKAT_Human0.90753149
155SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.90623667
156WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.89484618
157YY1_22570637_ChIP-Seq_MALME-3M_Human0.89104057
158NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88265772
159CTCF_21964334_Chip-Seq_Bcells_Human0.87843452
160* SOX2_18555785_ChIP-Seq_MESCs_Mouse0.87713367
161* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87684562
162BCOR_27268052_Chip-Seq_Bcells_Human0.87242499
163FOXO3_23340844_ChIP-Seq_DLD1_Human0.86558063
164* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.84961869
165CTCF_27219007_Chip-Seq_ERYTHROID_Human0.84787335
166POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.83843751
167RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.80530151
168THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.80453182
169* YY1_21170310_ChIP-Seq_MESCs_Mouse0.80238065
170NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.78606478
171KAP1_27257070_Chip-Seq_ESCs_Mouse0.78283720
172TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.77181530
173PHF8_20622854_ChIP-Seq_HELA_Human0.75387349
174SPI1_23127762_ChIP-Seq_K562_Human0.75293330
175ESR2_21235772_ChIP-Seq_MCF-7_Human0.73887143
176NANOG_16153702_ChIP-ChIP_HESCs_Human0.72885736
177CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.72108936
178CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.71947138

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat5.31764007
2MP0006292_abnormal_olfactory_placode4.36791390
3MP0005671_abnormal_response_to4.18477738
4MP0003011_delayed_dark_adaptation3.91314819
5MP0005499_abnormal_olfactory_system3.84987664
6MP0005394_taste/olfaction_phenotype3.84987664
7MP0004858_abnormal_nervous_system3.77368366
8MP0003724_increased_susceptibility_to3.70472267
9MP0004264_abnormal_extraembryonic_tissu3.61905702
10MP0003890_abnormal_embryonic-extraembry3.30964194
11MP0003303_peritoneal_inflammation3.25718207
12MP0005000_abnormal_immune_tolerance3.21117801
13MP0009785_altered_susceptibility_to3.16233595
14MP0005025_abnormal_response_to2.95038067
15MP0002419_abnormal_innate_immunity2.93691606
16MP0003705_abnormal_hypodermis_morpholog2.93570801
17MP0002723_abnormal_immune_serum2.88068112
18MP0002148_abnormal_hypersensitivity_rea2.79411016
19MP0002452_abnormal_antigen_presenting2.77650663
20MP0005257_abnormal_intraocular_pressure2.74312224
21MP0002332_abnormal_exercise_endurance2.72787263
22MP0002420_abnormal_adaptive_immunity2.68587360
23MP0001819_abnormal_immune_cell2.66117841
24MP0002653_abnormal_ependyma_morphology2.65812143
25MP0008057_abnormal_DNA_replication2.51335228
26MP0005075_abnormal_melanosome_morpholog2.49703253
27MP0010352_gastrointestinal_tract_polyps2.40654369
28MP0004957_abnormal_blastocyst_morpholog2.39814037
29MP0003183_abnormal_peptide_metabolism2.19318039
30MP0001348_abnormal_lacrimal_gland2.16089129
31MP0003763_abnormal_thymus_physiology2.14788949
32MP0000716_abnormal_immune_system2.05503865
33MP0002398_abnormal_bone_marrow2.04122315
34MP0003122_maternal_imprinting2.03527169
35MP0009333_abnormal_splenocyte_physiolog1.97698145
36MP0008961_abnormal_basal_metabolism1.94524346
37MP0003191_abnormal_cellular_cholesterol1.93018601
38MP0001845_abnormal_inflammatory_respons1.91728949
39MP0006082_CNS_inflammation1.89454087
40MP0001533_abnormal_skeleton_physiology1.87558964
41MP0005058_abnormal_lysosome_morphology1.85749349
42MP0002277_abnormal_respiratory_mucosa1.83098667
43MP0000678_abnormal_parathyroid_gland1.78797768
44MP0005464_abnormal_platelet_physiology1.76811192
45MP0006035_abnormal_mitochondrial_morpho1.73078823
46MP0003121_genomic_imprinting1.70367490
47MP0001672_abnormal_embryogenesis/_devel1.69936311
48MP0005380_embryogenesis_phenotype1.69936311
49MP0003938_abnormal_ear_development1.68906310
50MP0003806_abnormal_nucleotide_metabolis1.67582824
51MP0002429_abnormal_blood_cell1.67218216
52MP0010155_abnormal_intestine_physiology1.65971010
53MP0001849_ear_inflammation1.63831772
54MP0004947_skin_inflammation1.63235079
55MP0003300_gastrointestinal_ulcer1.61434231
56MP0003172_abnormal_lysosome_physiology1.60865181
57MP0010030_abnormal_orbit_morphology1.60855229
58MP0008260_abnormal_autophagy1.60070055
59MP0008469_abnormal_protein_level1.57254596
60MP0009764_decreased_sensitivity_to1.56834679
61MP0002932_abnormal_joint_morphology1.53523630
62MP0008789_abnormal_olfactory_epithelium1.51686996
63MP0002088_abnormal_embryonic_growth/wei1.50927186
64MP0003984_embryonic_growth_retardation1.49609684
65MP0000350_abnormal_cell_proliferation1.48841993
66MP0002127_abnormal_cardiovascular_syste1.46258088
67MP0009840_abnormal_foam_cell1.43149944
68MP0001873_stomach_inflammation1.31964408
69MP0002132_abnormal_respiratory_system1.30968401
70MP0001293_anophthalmia1.30528331
71MP0003283_abnormal_digestive_organ1.30516351
72MP0003077_abnormal_cell_cycle1.27246902
73MP0005451_abnormal_body_composition1.25265536
74MP0000703_abnormal_thymus_morphology1.25248078
75MP0005310_abnormal_salivary_gland1.24935847
76MP0001853_heart_inflammation1.23292805
77MP0002085_abnormal_embryonic_tissue1.21302409
78MP0003866_abnormal_defecation1.19328955
79MP0002092_abnormal_eye_morphology1.19099041
80MP0002086_abnormal_extraembryonic_tissu1.15363222
81MP0000465_gastrointestinal_hemorrhage1.14682113
82MP0003075_altered_response_to1.09260074
83MP0003111_abnormal_nucleus_morphology1.07162511
84MP0005248_abnormal_Harderian_gland1.06530347
85MP0004510_myositis1.06403828
86MP0002084_abnormal_developmental_patter1.06055416
87MP0002998_abnormal_bone_remodeling1.05360262
88MP0004883_abnormal_blood_vessel1.03966624
89MP0002970_abnormal_white_adipose0.97985719
90MP0008770_decreased_survivor_rate0.97449892
91MP0002233_abnormal_nose_morphology0.95302408
92MP0002138_abnormal_hepatobiliary_system0.95075882
93MP0003828_pulmonary_edema0.94883301
94MP0000604_amyloidosis0.93008794
95MP0009763_increased_sensitivity_to0.92607081
96MP0003315_abnormal_perineum_morphology0.92569556
97MP0009278_abnormal_bone_marrow0.92188815
98MP0000428_abnormal_craniofacial_morphol0.91698258
99MP0002114_abnormal_axial_skeleton0.90584123
100MP0004381_abnormal_hair_follicle0.90021090
101MP0003448_altered_tumor_morphology0.89769593
102MP0001730_embryonic_growth_arrest0.89470052
103MP0005266_abnormal_metabolism0.89416176
104MP0000049_abnormal_middle_ear0.88571115
105MP0000762_abnormal_tongue_morphology0.87518812
106MP0002166_altered_tumor_susceptibility0.87407495
107MP0001851_eye_inflammation0.86695993
108MP0001663_abnormal_digestive_system0.86500266
109MP0000313_abnormal_cell_death0.86289861
110MP0003755_abnormal_palate_morphology0.86000515
111MP0003935_abnormal_craniofacial_develop0.84739127
112MP0005397_hematopoietic_system_phenotyp0.83247692
113MP0001545_abnormal_hematopoietic_system0.83247692
114MP0005167_abnormal_blood-brain_barrier0.83138287
115MP0001790_abnormal_immune_system0.80044116
116MP0005387_immune_system_phenotype0.80044116
117MP0002396_abnormal_hematopoietic_system0.79109840
118MP0005166_decreased_susceptibility_to0.78223032
119MP0002925_abnormal_cardiovascular_devel0.77893675
120MP0000750_abnormal_muscle_regeneration0.77739024
121MP0000432_abnormal_head_morphology0.77641522
122MP0005023_abnormal_wound_healing0.77295956
123MP0000858_altered_metastatic_potential0.76673171
124MP0001697_abnormal_embryo_size0.75478093
125MP0000490_abnormal_crypts_of0.74916629
126MP0002080_prenatal_lethality0.74661836
127MP0003119_abnormal_digestive_system0.74291400
128MP0003566_abnormal_cell_adhesion0.74154293
129MP0003436_decreased_susceptibility_to0.73690369
130MP0005197_abnormal_uvea_morphology0.72684975
131MP0003221_abnormal_cardiomyocyte_apopto0.71994347
132MP0008932_abnormal_embryonic_tissue0.71302895
133MP0000015_abnormal_ear_pigmentation0.70617773
134MP0009765_abnormal_xenobiotic_induced0.70472349
135MP0005390_skeleton_phenotype0.70438302
136MP0005164_abnormal_response_to0.70309041
137MP0003123_paternal_imprinting0.70084120
138MP0003091_abnormal_cell_migration0.69382219
139MP0001800_abnormal_humoral_immune0.69192533
140MP0003787_abnormal_imprinting0.68539320
141MP0002751_abnormal_autonomic_nervous0.67832805
142MP0004197_abnormal_fetal_growth/weight/0.67771540
143MP0005508_abnormal_skeleton_morphology0.67167437
144MP0008874_decreased_physiological_sensi0.66913692
145MP0005384_cellular_phenotype0.66623634
146MP0002405_respiratory_system_inflammati0.66030716
147MP0003137_abnormal_impulse_conducting0.65197545
148MP0008995_early_reproductive_senescence0.63403638
149MP0010094_abnormal_chromosome_stability0.63256325
150MP0002163_abnormal_gland_morphology0.63139790
151MP0005621_abnormal_cell_physiology0.62578549
152MP0005391_vision/eye_phenotype0.62576238
153MP0002116_abnormal_craniofacial_bone0.62367905
154MP0000358_abnormal_cell_content/0.62049417
155MP0002693_abnormal_pancreas_physiology0.61569186
156MP0000343_altered_response_to0.61511209
157MP0003861_abnormal_nervous_system0.59957051
158MP0002006_tumorigenesis0.59721431
159MP0005319_abnormal_enzyme/_coenzyme0.59655914
160MP0002019_abnormal_tumor_incidence0.59027715
161MP0001835_abnormal_antigen_presentation0.58399530
162MP0003656_abnormal_erythrocyte_physiolo0.57701719
163MP0003795_abnormal_bone_structure0.57419623
164MP0003937_abnormal_limbs/digits/tail_de0.56605469
165MP0000609_abnormal_liver_physiology0.56318913
166MP0002081_perinatal_lethality0.56311886
167MP0000685_abnormal_immune_system0.55670707
168MP0002722_abnormal_immune_system0.54046918
169MP0000689_abnormal_spleen_morphology0.53606437
170MP0000249_abnormal_blood_vessel0.52993769
171MP0003786_premature_aging0.51522402
172MP0001986_abnormal_taste_sensitivity0.49000268
173MP0008873_increased_physiological_sensi0.48988127
174MP0005084_abnormal_gallbladder_morpholo0.45838530
175MP0006036_abnormal_mitochondrial_physio0.45281392
176MP0005381_digestive/alimentary_phenotyp0.44817882
177MP0001542_abnormal_bone_strength0.44144162
178MP0005584_abnormal_enzyme/coenzyme_acti0.43323913

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)7.06430311
2Recurrent bacterial skin infections (HP:0005406)5.58844017
3Abnormality of macrophages (HP:0004311)5.55173404
4Recurrent abscess formation (HP:0002722)5.41347336
5Eczematoid dermatitis (HP:0000976)5.36207049
6Hypochromic microcytic anemia (HP:0004840)5.30999500
7Hepatoblastoma (HP:0002884)5.29599464
8Abnormality of the lower motor neuron (HP:0002366)5.27060416
9Mediastinal lymphadenopathy (HP:0100721)4.63584504
10Rib fusion (HP:0000902)4.61997765
11Multiple enchondromatosis (HP:0005701)4.54451409
12Optic neuritis (HP:0100653)4.42442184
13Retrobulbar optic neuritis (HP:0100654)4.42442184
14Orchitis (HP:0100796)4.40697294
15Myositis (HP:0100614)4.36650406
16Stomatitis (HP:0010280)4.35361788
17Recurrent gram-negative bacterial infections (HP:0005420)4.07882115
18Ependymoma (HP:0002888)4.00481351
19Recurrent skin infections (HP:0001581)3.99332655
20Recurrent fungal infections (HP:0002841)3.95068032
21Chronic mucocutaneous candidiasis (HP:0002728)3.85117690
22Recurrent cutaneous fungal infections (HP:0011370)3.85117690
23Meningitis (HP:0001287)3.82530987
24Chronic obstructive pulmonary disease (HP:0006510)3.80062694
25Obstructive lung disease (HP:0006536)3.80062694
26Abnormal delayed hypersensitivity skin test (HP:0002963)3.74698683
27Vasculitis (HP:0002633)3.74064106
28Elevated erythrocyte sedimentation rate (HP:0003565)3.64608309
29Chromosomal breakage induced by crosslinking agents (HP:0003221)3.64104613
30Urticaria (HP:0001025)3.54512710
31Testicular atrophy (HP:0000029)3.54258753
32Neoplasm of striated muscle (HP:0009728)3.50506563
33Vacuolated lymphocytes (HP:0001922)3.45883612
34Increased IgM level (HP:0003496)3.44289780
35Gastrointestinal infarctions (HP:0005244)3.37519678
36Gastrointestinal stroma tumor (HP:0100723)3.34699646
37Amyotrophic lateral sclerosis (HP:0007354)3.32276091
38Encephalitis (HP:0002383)3.27505188
39Pulmonary infiltrates (HP:0002113)3.23807154
40Nephroblastoma (Wilms tumor) (HP:0002667)3.16395975
41Aplasia/Hypoplasia of the fovea (HP:0008060)3.15168518
42Hypoplasia of the fovea (HP:0007750)3.15168518
43Rhabdomyosarcoma (HP:0002859)3.11756680
44Increased cerebral lipofuscin (HP:0011813)3.11399600
45Recurrent viral infections (HP:0004429)3.10663580
46Fused cervical vertebrae (HP:0002949)3.08813786
47Lymphopenia (HP:0001888)3.08438691
48Autoimmune thrombocytopenia (HP:0001973)3.07127735
49Chromsome breakage (HP:0040012)3.05096799
50Abnormality of T cells (HP:0002843)2.96129729
51Abnormality of cells of the lymphoid lineage (HP:0012140)2.95326842
52Keratoconjunctivitis sicca (HP:0001097)2.93044170
53Astrocytoma (HP:0009592)2.91993435
54Abnormality of the astrocytes (HP:0100707)2.91993435
55Hemoptysis (HP:0002105)2.91047122
56Embryonal renal neoplasm (HP:0011794)2.89746554
57Generalized hypotonia (HP:0001290)2.88084023
58Keratoconjunctivitis (HP:0001096)2.87721033
59Abnormality of T cell number (HP:0011839)2.86825100
60Recurrent sinusitis (HP:0011108)2.80915576
61Abnormality of the phalanges of the hallux (HP:0010057)2.76389525
62Aplasia/hypoplasia of the humerus (HP:0006507)2.74407579
63Bifid tongue (HP:0010297)2.73915910
64Abnormality of T cell physiology (HP:0011840)2.72193257
65Shawl scrotum (HP:0000049)2.71826851
66Short humerus (HP:0005792)2.71574788
67Increased neuronal autofluorescent lipopigment (HP:0002074)2.71129890
68T lymphocytopenia (HP:0005403)2.70381931
69Abnormality of the distal phalanx of the thumb (HP:0009617)2.67823300
70Hypochromic anemia (HP:0001931)2.63097046
71Trismus (HP:0000211)2.61920079
72Loss of speech (HP:0002371)2.61706477
73Rectal fistula (HP:0100590)2.60517804
74Rectovaginal fistula (HP:0000143)2.60517804
75Hand muscle atrophy (HP:0009130)2.59910068
76Large earlobe (HP:0009748)2.59275014
77Chest pain (HP:0100749)2.57920735
78Nasal polyposis (HP:0100582)2.57314027
79Intestinal fistula (HP:0100819)2.56846265
80Horizontal nystagmus (HP:0000666)2.54393602
81Neoplasm of the heart (HP:0100544)2.54289855
82Cellulitis (HP:0100658)2.51232524
83IgG deficiency (HP:0004315)2.50677293
84Gingivitis (HP:0000230)2.49693002
85Abnormal lung lobation (HP:0002101)2.49410930
86Preauricular skin tag (HP:0000384)2.49335230
87Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.48912122
88Panhypogammaglobulinemia (HP:0003139)2.46911828
89Abnormality of the fovea (HP:0000493)2.46586225
90Leukocytosis (HP:0001974)2.46562783
91Spontaneous hematomas (HP:0007420)2.45852770
92Abnormality of the salivary glands (HP:0010286)2.45189606
93Anomalous pulmonary venous return (HP:0010772)2.44914747
94Anorexia (HP:0002039)2.44378324
95Progressive neurologic deterioration (HP:0002344)2.44059120
96Agammaglobulinemia (HP:0004432)2.43234812
97Aplasia/Hypoplasia of the sternum (HP:0006714)2.42917691
98Abnormal cartilage morphology (HP:0002763)2.42454010
99Aplasia/Hypoplasia of the uvula (HP:0010293)2.41219758
100Increased IgE level (HP:0003212)2.40090841
101Ragged-red muscle fibers (HP:0003200)2.39730454
102Granulocytopenia (HP:0001913)2.38667378
103Meckel diverticulum (HP:0002245)2.37954160
104IgM deficiency (HP:0002850)2.37675800
105Mutism (HP:0002300)2.37263695
106Pustule (HP:0200039)2.34634493
107Preauricular pit (HP:0004467)2.33533973
108Periauricular skin pits (HP:0100277)2.33533973
109Petechiae (HP:0000967)2.32455855
110Skin tags (HP:0010609)2.31461647
111Abnormality of small intestinal villus morphology (HP:0011472)2.28272462
112Villous atrophy (HP:0011473)2.28272462
113Vaginal fistula (HP:0004320)2.27693138
114Abnormality of the pubic bones (HP:0003172)2.26036967
115Abnormality of chromosome segregation (HP:0002916)2.25842283
116Renal duplication (HP:0000075)2.24891600
117Partial duplication of thumb phalanx (HP:0009944)2.24603028
118Upper motor neuron abnormality (HP:0002127)2.24190392
119Increased serum ferritin (HP:0003281)2.24183111
120Difficulty running (HP:0009046)2.22911316
121Aplasia/Hypoplasia of the macula (HP:0008059)2.22319364
122Hepatosplenomegaly (HP:0001433)2.21149750
123Abnormality of the ileum (HP:0001549)2.20672284
124Abnormality of the nasal mucosa (HP:0000433)2.19814264
125Hypertensive crisis (HP:0100735)2.18646438
126Hypergammaglobulinemia (HP:0010702)2.18510920
127Dysostosis multiplex (HP:0000943)2.17633065
128Restrictive lung disease (HP:0002091)2.17349783
129Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.17199076
130Abnormality of the musculature of the hand (HP:0001421)2.16785395
131Gangrene (HP:0100758)2.16138004
132Episodic fever (HP:0001954)2.15197857
133Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.15086626
134Acute hepatic failure (HP:0006554)2.15002893
135Tetraplegia (HP:0002445)2.14723385
136Hypopigmentation of the fundus (HP:0007894)2.14435587
137Distal upper limb amyotrophy (HP:0007149)2.14285681
138Upper limb amyotrophy (HP:0009129)2.14285681
139Joint swelling (HP:0001386)2.14150630
140Disinhibition (HP:0000734)2.13222019
141Arterial thrombosis (HP:0004420)2.13082422
142Aplasia/Hypoplasia affecting the retina (HP:0008061)2.12915079
143Eosinophilia (HP:0001880)2.11772725
144Abnormality of liposaccharide metabolism (HP:0010968)2.10037505
145Abnormality of glycosphingolipid metabolism (HP:0004343)2.10037505
146Abnormality of glycolipid metabolism (HP:0010969)2.10037505
147Premature ovarian failure (HP:0008209)2.09819999
148Atrophy/Degeneration involving motor neurons (HP:0007373)2.09702587
149Progressive muscle weakness (HP:0003323)2.09248078
150Upper limb muscle weakness (HP:0003484)2.08611395
151Achilles tendon contracture (HP:0001771)2.08520367
152IgA deficiency (HP:0002720)2.08317931
153Inflammation of the large intestine (HP:0002037)2.07710524
154Abnormality of eosinophils (HP:0001879)2.07469254
155Cheilitis (HP:0100825)2.07189590
156Increased connective tissue (HP:0009025)2.06048090
157Sepsis (HP:0100806)2.05408884
158Abnormality of the pleura (HP:0002103)2.04194232
159Recurrent bronchitis (HP:0002837)2.03342340
160Tongue fasciculations (HP:0001308)2.02705764
161Recurrent pneumonia (HP:0006532)2.01416093
162Leukopenia (HP:0001882)2.00548648
163Sensory axonal neuropathy (HP:0003390)2.00454485
164Hyperinsulinemic hypoglycemia (HP:0000825)1.98644718
165Abnormality of the pulmonary veins (HP:0011718)1.98298682
166Short 5th finger (HP:0009237)1.97642173
167Gastrointestinal inflammation (HP:0004386)1.97332392
168Pendular nystagmus (HP:0012043)1.97157584
169Arthralgia (HP:0002829)1.96213550
170Pulmonary embolism (HP:0002204)1.95679798
171Polyneuropathy (HP:0001271)1.94672214
172Osteomyelitis (HP:0002754)1.94630952
173Glomerulopathy (HP:0100820)1.93903787
174Partial duplication of the phalanx of hand (HP:0009999)1.93822262
175Skin rash (HP:0000988)1.93446831
176Recurrent lower respiratory tract infections (HP:0002783)1.92808441
177Pseudobulbar signs (HP:0002200)1.92796410
178Amblyopia (HP:0000646)1.92312623
179Aplastic anemia (HP:0001915)1.91123801
180Abnormality of iron homeostasis (HP:0011031)1.91123132
181Skin pits (HP:0100276)1.90994299
182Duodenal stenosis (HP:0100867)1.90961181
183Small intestinal stenosis (HP:0012848)1.90961181
184Impulsivity (HP:0100710)1.90623664
185Muscle fibrillation (HP:0010546)1.90502944
186Emphysema (HP:0002097)1.89732832
187Peritonitis (HP:0002586)1.89052949
188Combined immunodeficiency (HP:0005387)1.88373904
189Malignant neoplasm of the central nervous system (HP:0100836)1.88113981
190Chronic otitis media (HP:0000389)1.88021863
191Glioma (HP:0009733)1.87113771
192Chronic diarrhea (HP:0002028)1.87113232
193Reduced antithrombin III activity (HP:0001976)1.87041247
194Abnormality of the endocardium (HP:0004306)1.86448588
195Fasciculations (HP:0002380)1.86166548

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.80458218
2GRK55.00303110
3MAP4K14.88391386
4ERN14.75083055
5GRK64.21618277
6TAOK33.56252934
7TXK3.24034025
8IRAK43.06448500
9ADRBK23.03149176
10GRK12.72328866
11CSF1R2.71935771
12TYRO32.60646974
13MOS2.40899053
14STK102.38766799
15TTK2.28517794
16TGFBR22.25637682
17MAP3K142.21064362
18TBK12.18152847
19MATK2.14053301
20IKBKE2.13610626
21WNK11.99254764
22MAPK71.97688207
23MAP2K31.94807948
24JAK31.84422724
25SIK31.76134189
26FGR1.72695455
27SYK1.66674872
28MAP3K101.66481137
29GRK71.65726029
30ZAP701.64746096
31MAP3K111.63079655
32NTRK11.62491389
33FES1.60259960
34MAP3K91.58974466
35MAP3K31.55308687
36LYN1.50273257
37MARK21.49541407
38CAMK41.43740344
39BTK1.42644972
40JAK11.40089238
41FGFR31.38447634
42TNK21.36803983
43PRKG21.28196195
44EPHB11.27876712
45PAK41.27655315
46BMPR21.19388219
47LATS21.17767680
48CDK71.16492648
49HIPK21.16484045
50KIT1.13325788
51CHEK21.09883953
52ALK1.09626998
53LCK1.08973633
54BCKDK1.05887005
55MAP2K41.03103621
56EPHA21.01027777
57NME20.99216691
58CSK0.96901986
59PRKCQ0.95608394
60SIK20.94590530
61MAP3K70.94439794
62PIM20.94332330
63ADRBK10.93472729
64SMG10.87762936
65PLK10.83325634
66CDK190.82353215
67IRAK30.81805044
68EPHA30.80188696
69TRIB30.77335212
70MAP3K10.76989649
71NEK20.74906625
72MAP3K50.72770014
73TEC0.70442438
74PRKD20.69842583
75MAP3K130.68564509
76TAOK10.68413631
77PDK10.68309366
78CHEK10.66447393
79TESK20.65943615
80IRAK20.65861175
81STK160.65715119
82PIM10.64675332
83IRAK10.63718014
84BLK0.62910610
85IKBKB0.61291741
86STK380.59192628
87DAPK20.57882044
88DYRK20.57424835
89PTK20.57165591
90PRKD30.55987902
91PDPK10.55807392
92MTOR0.54939350
93MAP2K60.53951586
94STK240.53183891
95AKT20.53102042
96ARAF0.49195146
97CAMKK20.48853491
98RIPK10.48555881
99MAPK120.48021067
100NEK90.47783607
101PTK2B0.46923954
102PAK60.45818109
103CDC42BPA0.45138719
104YES10.44524573
105CCNB10.44331989
106BMX0.42914607
107ZAK0.42894592
108CHUK0.42821991
109AKT30.41937270
110DYRK30.40073683
111EIF2AK20.40058118
112FYN0.38798647
113RPS6KA60.37745403
114KSR20.37205155
115RPS6KL10.37038936
116RPS6KC10.37038936
117CDK20.36625889
118MAPKAPK30.36526425
119DYRK1B0.35236209
120PRKCI0.35189923
121ITK0.34651273
122MAPK110.34188089
123TYK20.33714722
124PIK3CG0.33280924
125AURKA0.32716746
126PAK10.32546898
127PRKCD0.32287383
128NME10.32055047
129TLK10.31465404
130IGF1R0.30367087
131MAPK100.27775055
132RIPK40.27484986
133HCK0.26972945
134DYRK1A0.26277458
135ABL10.26186691
136PRKCZ0.26012354
137RAF10.25177385
138FGFR40.24694491
139LIMK10.24662325
140PRPF4B0.23958559
141INSR0.23281955
142CDK40.22894913
143ATM0.21250267
144PRKAA10.20607205
145ERBB20.20227250
146PDGFRA0.18655165
147MAP3K80.18483163
148PAK30.18280109
149GSK3B0.18134844
150BUB10.17618888
151TAOK20.17574135
152JAK20.17318966
153MAPK10.16167104
154MARK30.15553762
155ICK0.14959168
156LATS10.14764319
157CDK10.14581996
158CSNK1E0.14507768
159CDK150.14401888
160MAPKAPK20.12342432
161CAMK1D0.12322296
162MAPK140.12276526

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006035.20602040
2Vitamin B6 metabolism_Homo sapiens_hsa007505.03208984
3Allograft rejection_Homo sapiens_hsa053303.67100901
4Autoimmune thyroid disease_Homo sapiens_hsa053203.39415620
5Graft-versus-host disease_Homo sapiens_hsa053323.23428878
6Fructose and mannose metabolism_Homo sapiens_hsa000512.81709880
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.77102908
8Asthma_Homo sapiens_hsa053102.76669973
9Osteoclast differentiation_Homo sapiens_hsa043802.67769981
10Staphylococcus aureus infection_Homo sapiens_hsa051502.58829036
11Type I diabetes mellitus_Homo sapiens_hsa049402.57749971
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.35264758
13Toll-like receptor signaling pathway_Homo sapiens_hsa046202.33165155
14Antigen processing and presentation_Homo sapiens_hsa046122.31021564
15mTOR signaling pathway_Homo sapiens_hsa041502.04865007
16Viral myocarditis_Homo sapiens_hsa054161.91317130
17Rheumatoid arthritis_Homo sapiens_hsa053231.87935957
18Measles_Homo sapiens_hsa051621.86720570
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.76078751
20Arachidonic acid metabolism_Homo sapiens_hsa005901.70800460
21Galactose metabolism_Homo sapiens_hsa000521.66523376
22Hematopoietic cell lineage_Homo sapiens_hsa046401.60566075
23Lysosome_Homo sapiens_hsa041421.59993911
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.57497301
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.54260036
26Phagosome_Homo sapiens_hsa041451.46845374
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.45958651
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41207867
29Linoleic acid metabolism_Homo sapiens_hsa005911.39891516
30Thyroid cancer_Homo sapiens_hsa052161.39780683
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.39330749
32Legionellosis_Homo sapiens_hsa051341.35137093
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.33223848
34Phospholipase D signaling pathway_Homo sapiens_hsa040721.32644310
35Malaria_Homo sapiens_hsa051441.32010535
36Other glycan degradation_Homo sapiens_hsa005111.24657807
37mRNA surveillance pathway_Homo sapiens_hsa030151.24561948
38Shigellosis_Homo sapiens_hsa051311.22521296
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.21908399
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.20665951
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.20629077
42RNA transport_Homo sapiens_hsa030131.20211746
43Epstein-Barr virus infection_Homo sapiens_hsa051691.17099446
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.16906981
45Acute myeloid leukemia_Homo sapiens_hsa052211.15945262
46Fanconi anemia pathway_Homo sapiens_hsa034601.12963693
47Pentose and glucuronate interconversions_Homo sapiens_hsa000401.12858248
48Cell cycle_Homo sapiens_hsa041101.10967692
49Non-small cell lung cancer_Homo sapiens_hsa052231.10794387
50Hepatitis B_Homo sapiens_hsa051611.09416467
51Regulation of actin cytoskeleton_Homo sapiens_hsa048101.09249292
52B cell receptor signaling pathway_Homo sapiens_hsa046621.08619934
53MicroRNAs in cancer_Homo sapiens_hsa052061.08599068
54VEGF signaling pathway_Homo sapiens_hsa043701.07742206
55Inositol phosphate metabolism_Homo sapiens_hsa005621.06913538
56Thyroid hormone signaling pathway_Homo sapiens_hsa049191.06628362
57Choline metabolism in cancer_Homo sapiens_hsa052311.06322607
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.06013922
59NF-kappa B signaling pathway_Homo sapiens_hsa040641.04881391
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.04270854
61Apoptosis_Homo sapiens_hsa042101.03910999
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00780269
63Sulfur relay system_Homo sapiens_hsa041220.99692621
64Ovarian steroidogenesis_Homo sapiens_hsa049130.99552820
65Collecting duct acid secretion_Homo sapiens_hsa049660.98835751
66Herpes simplex infection_Homo sapiens_hsa051680.95539928
67Pertussis_Homo sapiens_hsa051330.95095925
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94281243
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.93654471
70Pancreatic cancer_Homo sapiens_hsa052120.92771066
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92591043
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90592196
73Salmonella infection_Homo sapiens_hsa051320.89203080
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88988381
75GnRH signaling pathway_Homo sapiens_hsa049120.88429751
76Pathways in cancer_Homo sapiens_hsa052000.88031493
77Bladder cancer_Homo sapiens_hsa052190.87660092
78Rap1 signaling pathway_Homo sapiens_hsa040150.87304828
79Leishmaniasis_Homo sapiens_hsa051400.86558025
80p53 signaling pathway_Homo sapiens_hsa041150.85630824
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84784999
82Notch signaling pathway_Homo sapiens_hsa043300.84332263
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83653301
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81942281
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.78333298
86Hedgehog signaling pathway_Homo sapiens_hsa043400.77994564
87Influenza A_Homo sapiens_hsa051640.76393554
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75879114
89T cell receptor signaling pathway_Homo sapiens_hsa046600.75038865
90African trypanosomiasis_Homo sapiens_hsa051430.74826620
91Primary immunodeficiency_Homo sapiens_hsa053400.72476760
92Dorso-ventral axis formation_Homo sapiens_hsa043200.71690339
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70965549
94Proteoglycans in cancer_Homo sapiens_hsa052050.70583388
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.68742575
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68328958
97Basal cell carcinoma_Homo sapiens_hsa052170.67874839
98Hippo signaling pathway_Homo sapiens_hsa043900.66788696
99Small cell lung cancer_Homo sapiens_hsa052220.66545628
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.65874931
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.63411727
102Prolactin signaling pathway_Homo sapiens_hsa049170.60758109
103Chronic myeloid leukemia_Homo sapiens_hsa052200.60184765
104Jak-STAT signaling pathway_Homo sapiens_hsa046300.59947807
105HTLV-I infection_Homo sapiens_hsa051660.58363263
106Intestinal immune network for IgA production_Homo sapiens_hsa046720.58084296
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58022064
108Colorectal cancer_Homo sapiens_hsa052100.57641491
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56925929
110MAPK signaling pathway_Homo sapiens_hsa040100.56872832
111Toxoplasmosis_Homo sapiens_hsa051450.56719202
112Proteasome_Homo sapiens_hsa030500.53078495
113Ras signaling pathway_Homo sapiens_hsa040140.51931898
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51859248
115RNA degradation_Homo sapiens_hsa030180.51763202
116Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.49986407
117Glioma_Homo sapiens_hsa052140.49614689
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.49075329
119AMPK signaling pathway_Homo sapiens_hsa041520.48704429
120Endometrial cancer_Homo sapiens_hsa052130.47522727
121Hepatitis C_Homo sapiens_hsa051600.46882385
122ErbB signaling pathway_Homo sapiens_hsa040120.46632897
123Tuberculosis_Homo sapiens_hsa051520.46539996
124Viral carcinogenesis_Homo sapiens_hsa052030.46279116
125Endocytosis_Homo sapiens_hsa041440.45741596
126AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44944565
127One carbon pool by folate_Homo sapiens_hsa006700.44742277
128TNF signaling pathway_Homo sapiens_hsa046680.43622673
129Systemic lupus erythematosus_Homo sapiens_hsa053220.43535714
130Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42782958
131Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41478824
132Oocyte meiosis_Homo sapiens_hsa041140.40698828
133Long-term depression_Homo sapiens_hsa047300.38573986
134Wnt signaling pathway_Homo sapiens_hsa043100.38297557
135Chemokine signaling pathway_Homo sapiens_hsa040620.37906064
136Regulation of autophagy_Homo sapiens_hsa041400.37460038
137Adipocytokine signaling pathway_Homo sapiens_hsa049200.37288249
138Adherens junction_Homo sapiens_hsa045200.36937897
139Platelet activation_Homo sapiens_hsa046110.36303033
140Vibrio cholerae infection_Homo sapiens_hsa051100.34150233
141Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.26898206
142Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.23868516
143HIF-1 signaling pathway_Homo sapiens_hsa040660.23590788
144Renal cell carcinoma_Homo sapiens_hsa052110.21692903
145Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21205001
146Carbohydrate digestion and absorption_Homo sapiens_hsa049730.13113526
147Type II diabetes mellitus_Homo sapiens_hsa049300.09281910
148Sphingolipid metabolism_Homo sapiens_hsa006000.08895743
149Insulin resistance_Homo sapiens_hsa049310.07941215
150FoxO signaling pathway_Homo sapiens_hsa040680.04750758

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