SNX12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. A similar protein in mouse may be involved in regulating the neurite outgrowth. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to endosome (GO:0036010)4.22253387
2epithelial cell-cell adhesion (GO:0090136)3.81939369
3skin morphogenesis (GO:0043589)3.79006697
4protein retention in ER lumen (GO:0006621)3.76127268
5planar cell polarity pathway involved in neural tube closure (GO:0090179)3.69189859
6adherens junction assembly (GO:0034333)3.65864595
7maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.63488683
8cell-substrate junction assembly (GO:0007044)3.59701428
9hemidesmosome assembly (GO:0031581)3.55687378
10focal adhesion assembly (GO:0048041)3.51916827
11cell-substrate adherens junction assembly (GO:0007045)3.51916827
12positive regulation of actin filament depolymerization (GO:0030836)3.41648042
13cytoskeletal anchoring at plasma membrane (GO:0007016)3.40504807
14regulation of protein heterodimerization activity (GO:0043497)3.40186189
15regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.33752546
16retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.24715345
17desmosome organization (GO:0002934)3.18501605
18negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.12149425
19dopaminergic neuron differentiation (GO:0071542)3.12142547
20stress fiber assembly (GO:0043149)3.09516456
21regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.08600523
22regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.02750593
23modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.00261321
24modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.00261321
25positive regulation by organism of defense response of other organism involved in symbiotic interact3.00261321
26modulation by symbiont of host immune response (GO:0052553)3.00261321
27positive regulation by symbiont of host defense response (GO:0052509)3.00261321
28modulation by symbiont of host defense response (GO:0052031)3.00261321
29basement membrane organization (GO:0071711)3.00178670
30negative regulation of fatty acid transport (GO:2000192)2.94130039
31endodermal cell differentiation (GO:0035987)2.93655250
32regulation of mammary gland epithelial cell proliferation (GO:0033599)2.93163440
33apoptotic cell clearance (GO:0043277)2.92594403
34mitotic chromosome condensation (GO:0007076)2.92248897
35cellular protein complex localization (GO:0034629)2.88705205
36vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.81593885
37pentose-phosphate shunt (GO:0006098)2.79459158
38dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.79202012
39regulation of NFAT protein import into nucleus (GO:0051532)2.73852063
40regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.73574666
41Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.71205687
42membrane budding (GO:0006900)2.70640233
43regulation of glucose import in response to insulin stimulus (GO:2001273)2.69992471
44neuron projection extension involved in neuron projection guidance (GO:1902284)2.69552713
45axon extension involved in axon guidance (GO:0048846)2.69552713
46negative chemotaxis (GO:0050919)2.68889411
47pinocytosis (GO:0006907)2.68136383
48mitotic sister chromatid cohesion (GO:0007064)2.67559546
49protein maturation by protein folding (GO:0022417)2.65167322
50activation of Rac GTPase activity (GO:0032863)2.64243352
51vesicle coating (GO:0006901)2.63528797
52cortical actin cytoskeleton organization (GO:0030866)2.62845867
53hypotonic response (GO:0006971)2.62832798
54activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.61760741
55positive regulation of chemokine biosynthetic process (GO:0045080)2.60596455
56protein complex localization (GO:0031503)2.58332173
57ribosomal small subunit biogenesis (GO:0042274)2.57759469
58protein localization to microtubule (GO:0035372)2.54946512
59activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.54521142
60regulation of establishment of planar polarity (GO:0090175)2.53895330
61nucleobase-containing small molecule interconversion (GO:0015949)2.53552570
62positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.53124243
63heterochromatin organization (GO:0070828)2.52347735
64peptidyl-proline hydroxylation (GO:0019511)2.51427039
65maternal placenta development (GO:0001893)2.50168978
66NADPH regeneration (GO:0006740)2.49603536
67positive regulation of blood vessel endothelial cell migration (GO:0043536)2.49485010
68cell-cell junction maintenance (GO:0045217)2.47356967
69Arp2/3 complex-mediated actin nucleation (GO:0034314)2.46593964
70positive regulation of endothelial cell apoptotic process (GO:2000353)2.46452024
71positive regulation of nuclease activity (GO:0032075)2.46340450
72cell migration involved in heart development (GO:0060973)2.45183250
73epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.43691728
74negative regulation of chondrocyte differentiation (GO:0032331)2.43431815
75peptidyl-arginine methylation (GO:0018216)2.42799691
76peptidyl-arginine N-methylation (GO:0035246)2.42799691
77convergent extension (GO:0060026)2.41842885
78DNA unwinding involved in DNA replication (GO:0006268)2.41734990
79apoptotic process involved in morphogenesis (GO:0060561)2.41441352
80embryonic process involved in female pregnancy (GO:0060136)2.40742737
81endocytic recycling (GO:0032456)2.40356836
82* regulation of early endosome to late endosome transport (GO:2000641)2.39062707
83positive regulation of Cdc42 GTPase activity (GO:0043089)2.37962355
84regulation of glucocorticoid metabolic process (GO:0031943)2.37807644
85negative regulation of adherens junction organization (GO:1903392)2.37614390
86negative regulation of focal adhesion assembly (GO:0051895)2.37614390
87negative regulation of cell junction assembly (GO:1901889)2.37614390
88negative regulation of axon guidance (GO:1902668)2.36800683
89proline biosynthetic process (GO:0006561)2.36279899
90receptor recycling (GO:0001881)2.35419183
91retina vasculature morphogenesis in camera-type eye (GO:0061299)2.34538026
92positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.34472763
93actin filament bundle organization (GO:0061572)2.33665344
94actin filament bundle assembly (GO:0051017)2.33665344
95glucose catabolic process (GO:0006007)2.32571681
96response to laminar fluid shear stress (GO:0034616)2.31870325
97negative regulation of microtubule polymerization (GO:0031115)2.31630034
98cortical cytoskeleton organization (GO:0030865)2.30544787
99positive regulation of protein depolymerization (GO:1901881)2.30451362
100branching involved in mammary gland duct morphogenesis (GO:0060444)2.30171447
101peptidyl-arginine omega-N-methylation (GO:0035247)2.29824577
102negative regulation of protein localization to plasma membrane (GO:1903077)2.29415986
103notochord development (GO:0030903)2.29266745
104SMAD protein complex assembly (GO:0007183)2.28492807
105COPI coating of Golgi vesicle (GO:0048205)2.27813411
106Golgi transport vesicle coating (GO:0048200)2.27813411
107protein hydroxylation (GO:0018126)2.27734849
108antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.27468017
109endoplasmic reticulum unfolded protein response (GO:0030968)2.27088493
110negative regulation of axon extension involved in axon guidance (GO:0048843)2.26712452
111regulation of translational fidelity (GO:0006450)2.26125791
112endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.25839539
113adhesion of symbiont to host (GO:0044406)2.25431582
114barbed-end actin filament capping (GO:0051016)2.25251454
115paraxial mesoderm development (GO:0048339)2.24462808
116embryo implantation (GO:0007566)2.24205864
117positive regulation of interleukin-1 beta secretion (GO:0050718)2.23283223
118positive regulation of receptor recycling (GO:0001921)2.22343701
119regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.22212305
120positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.22212305
121endothelial cell morphogenesis (GO:0001886)2.21830697
122urogenital system development (GO:0001655)2.21277587
123positive regulation of interleukin-1 beta production (GO:0032731)2.20784652
124protein deneddylation (GO:0000338)2.20166384
125collagen fibril organization (GO:0030199)2.19991526
126virion attachment to host cell (GO:0019062)2.19947435
127adhesion of symbiont to host cell (GO:0044650)2.19947435
128epithelial cell differentiation involved in prostate gland development (GO:0060742)2.19312217
129bone trabecula formation (GO:0060346)2.19109120
130sister chromatid segregation (GO:0000819)2.18945374
131cullin deneddylation (GO:0010388)2.18724508
132protein localization to kinetochore (GO:0034501)2.18572777
133hyaluronan catabolic process (GO:0030214)2.18527719
134establishment of nucleus localization (GO:0040023)2.18340013
135cranial nerve morphogenesis (GO:0021602)2.17969036
136spindle assembly checkpoint (GO:0071173)2.17889752
137mitotic spindle assembly checkpoint (GO:0007094)2.17157392
138pre-miRNA processing (GO:0031054)2.14736182
139spindle checkpoint (GO:0031577)2.13501740
140kinetochore assembly (GO:0051382)2.13311588
141cell proliferation involved in metanephros development (GO:0072203)2.12752126
142positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.10912679
143histamine secretion (GO:0001821)2.10445811
144semaphorin-plexin signaling pathway (GO:0071526)2.09471690
145positive regulation of lamellipodium assembly (GO:0010592)2.09129447
146attachment of spindle microtubules to kinetochore (GO:0008608)2.06876061
147cell adhesion mediated by integrin (GO:0033627)2.06690720
148histone deubiquitination (GO:0016578)2.06488488
149positive regulation vascular endothelial growth factor production (GO:0010575)2.06286761
150regulation of chemokine biosynthetic process (GO:0045073)2.05377746
151craniofacial suture morphogenesis (GO:0097094)2.04379043
152sequestering of actin monomers (GO:0042989)2.04195508
153positive regulation of lamellipodium organization (GO:1902745)2.03736061
154positive regulation of interleukin-1 production (GO:0032732)2.03599763
155positive regulation of mast cell activation involved in immune response (GO:0033008)2.03347428
156positive regulation of mast cell degranulation (GO:0043306)2.03347428
157positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.03208383
158regulation of SMAD protein import into nucleus (GO:0060390)2.02406313
159hippo signaling (GO:0035329)2.02309845
160kinetochore organization (GO:0051383)2.02238529
161mitotic spindle checkpoint (GO:0071174)2.00837481
162glucocorticoid receptor signaling pathway (GO:0042921)2.00242250
163de novo protein folding (GO:0006458)1.99802288
164actin nucleation (GO:0045010)1.99297680
165negative regulation of mitotic metaphase/anaphase transition (GO:0045841)1.99296041
166negative regulation of sister chromatid segregation (GO:0033046)1.99296041
167negative regulation of mitotic sister chromatid separation (GO:2000816)1.99296041
168negative regulation of mitotic sister chromatid segregation (GO:0033048)1.99296041
169gastrulation with mouth forming second (GO:0001702)1.98523148
170negative regulation of histone acetylation (GO:0035067)1.97760523
171negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)1.97411503
172vagina development (GO:0060068)1.96868314
173positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610811.95713815
174negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)1.95345786
175regulation of chemokine-mediated signaling pathway (GO:0070099)1.95209561
176negative regulation of chromosome segregation (GO:0051985)1.94607437
177de novo posttranslational protein folding (GO:0051084)1.94559744
178positive regulation of leukocyte degranulation (GO:0043302)1.93949328
179chondrocyte proliferation (GO:0035988)1.92711354
180histone arginine methylation (GO:0034969)1.92196009
181regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)1.91539395
182regulation of mitotic spindle checkpoint (GO:1903504)1.91539395
183DNA demethylation (GO:0080111)1.90507417
184response to defenses of other organism involved in symbiotic interaction (GO:0052173)1.90455922
185response to host (GO:0075136)1.90455922
186response to host defenses (GO:0052200)1.90455922
187nodal signaling pathway (GO:0038092)1.89668406
188mitotic spindle organization (GO:0007052)1.89635830
189positive regulation of interleukin-1 secretion (GO:0050716)1.88754078

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human5.25472398
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.63290049
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.45238886
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.55076019
5E2F7_22180533_ChIP-Seq_HELA_Human3.13175980
6RARG_19884340_ChIP-ChIP_MEFs_Mouse3.10047478
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.98467927
8TP63_19390658_ChIP-ChIP_HaCaT_Human2.90185611
9CLOCK_20551151_ChIP-Seq_293T_Human2.54637412
10EZH2_22144423_ChIP-Seq_EOC_Human2.45606507
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.43258522
12ZNF263_19887448_ChIP-Seq_K562_Human2.39900489
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.24399332
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.16765034
15RACK7_27058665_Chip-Seq_MCF-7_Human2.12235889
16KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.11655658
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.09672746
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.01344379
19PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.98705107
20LXR_22292898_ChIP-Seq_THP-1_Human1.97404060
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.90351433
22ESR2_21235772_ChIP-Seq_MCF-7_Human1.90119932
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.88131670
24TRIM28_21343339_ChIP-Seq_HEK293_Human1.87442983
25IGF1R_20145208_ChIP-Seq_DFB_Human1.84289919
26ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.82062997
27KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.78520741
28SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.77006427
29KDM2B_26808549_Chip-Seq_K562_Human1.76305076
30POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.75958317
31* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.75781837
32ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.75240922
33E2F4_17652178_ChIP-ChIP_JURKAT_Human1.73086809
34TFEB_21752829_ChIP-Seq_HELA_Human1.72482154
35SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.68540895
36WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.67433745
37MYC_22102868_ChIP-Seq_BL_Human1.67395864
38EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.66847694
39KDM2B_26808549_Chip-Seq_SUP-B15_Human1.66433610
40ELK1_19687146_ChIP-ChIP_HELA_Human1.64924799
41TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.64843692
42KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.62899495
43KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.60513695
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.60043640
45TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.58973799
46PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.58053252
47KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.56332223
48XRN2_22483619_ChIP-Seq_HELA_Human1.55979616
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54364074
50TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.50532549
51BRD4_25478319_ChIP-Seq_HGPS_Human1.49749295
52CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.49504868
53ATF3_27146783_Chip-Seq_COLON_Human1.48539589
54* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.48159031
55MYC_18555785_ChIP-Seq_MESCs_Mouse1.47664646
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.45884131
57ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.44563856
58STAT6_21828071_ChIP-Seq_BEAS2B_Human1.41628647
59EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.41578125
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.40662180
61* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.40296566
62EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40231578
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38172363
64TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36620992
65HIF1A_21447827_ChIP-Seq_MCF-7_Human1.33183627
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32196378
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.31099282
68ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.30420049
69TCF7_22412390_ChIP-Seq_EML_Mouse1.30014478
70NELFA_20434984_ChIP-Seq_ESCs_Mouse1.29321231
71WT1_19549856_ChIP-ChIP_CCG9911_Human1.28072147
72PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.26312173
73ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.25969511
74NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.24868295
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.23200017
76NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22177761
77SRY_22984422_ChIP-ChIP_TESTIS_Rat1.20106495
78ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.19361052
79* TTF2_22483619_ChIP-Seq_HELA_Human1.19195780
80NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18558760
81ELK1_22589737_ChIP-Seq_MCF10A_Human1.17887764
82* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17850774
83AR_21909140_ChIP-Seq_LNCAP_Human1.17757277
84SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.17674436
85DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.17588147
86TP53_22127205_ChIP-Seq_IMR90_Human1.15665859
87SOX2_27498859_Chip-Seq_STOMACH_Mouse1.15032025
88EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.12895762
89* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.12248137
90TET1_21451524_ChIP-Seq_MESCs_Mouse1.11668384
91ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11460436
92NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.11335347
93ZNF274_21170338_ChIP-Seq_K562_Hela1.11129533
94KDM2B_26808549_Chip-Seq_JURKAT_Human1.10135938
95SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09620521
96CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.08598253
97ESR1_21235772_ChIP-Seq_MCF-7_Human1.08424275
98CIITA_25753668_ChIP-Seq_RAJI_Human1.08252755
99GABP_17652178_ChIP-ChIP_JURKAT_Human1.06973553
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06866305
101NANOG_18555785_ChIP-Seq_MESCs_Mouse1.05773594
102MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.05192705
103TCF3_18692474_ChIP-Seq_MEFs_Mouse1.04905606
104CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03273773
105PKCTHETA_26484144_Chip-Seq_BREAST_Human1.03129641
106STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02145980
107RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02064466
108SOX2_16153702_ChIP-ChIP_HESCs_Human1.02021021
109HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01712531
110MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.01611928
111TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.01607702
112TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01297658
113TBX20_22328084_ChIP-Seq_HEART_Mouse1.00806555
114TBX20_22080862_ChIP-Seq_HEART_Mouse1.00806555
115GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.00645621
116CREB1_26743006_Chip-Seq_LNCaP_Human1.00613631
117NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99741926
118P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99673667
119NANOG_21062744_ChIP-ChIP_HESCs_Human0.99318592
120VDR_21846776_ChIP-Seq_THP-1_Human0.99308462
121MYC_19079543_ChIP-ChIP_MESCs_Mouse0.99184356
122CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99134456
123CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98786473
124KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97592959
125CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.97579827
126OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96748196
127VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96657364
128ELK3_25401928_ChIP-Seq_HUVEC_Human0.96063629
129YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94585925
130STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.93581096
131SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93152469
132CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92939017
133NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.92099921
134DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90174748
135ESR1_15608294_ChIP-ChIP_MCF-7_Human0.89237391
136* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.88034471
137SPI1_23547873_ChIP-Seq_NB4_Human0.87628528
138DCP1A_22483619_ChIP-Seq_HELA_Human0.86708233
139ZFX_18555785_ChIP-Seq_MESCs_Mouse0.86181864
140* GABP_19822575_ChIP-Seq_HepG2_Human0.86149655
141PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.85550275
142SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.85467227
143CJUN_26792858_Chip-Seq_BT549_Human0.85398434
144EWS_26573619_Chip-Seq_HEK293_Human0.85231780
145MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.84757582
146RXR_22108803_ChIP-Seq_LS180_Human0.84553308
147MYCN_18555785_ChIP-Seq_MESCs_Mouse0.82907157
148TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.82065753
149KDM2B_26808549_Chip-Seq_DND41_Human0.81605644
150SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.80657719
151SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.80657719
152NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.80580570
153NANOG_16153702_ChIP-ChIP_HESCs_Human0.80478575
154KLF4_18555785_ChIP-Seq_MESCs_Mouse0.80073298
155* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.78275890
156UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.77904228
157VDR_24763502_ChIP-Seq_THP-1_Human0.77370522
158E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.76810040
159UBF1/2_26484160_Chip-Seq_HMECs_Human0.76554075

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.61263357
2MP0010234_abnormal_vibrissa_follicle3.50010384
3MP0010030_abnormal_orbit_morphology3.03720210
4MP0003122_maternal_imprinting2.71926073
5MP0005076_abnormal_cell_differentiation2.68563806
6MP0004272_abnormal_basement_membrane2.61061414
7MP0003941_abnormal_skin_development2.38470862
8MP0005409_darkened_coat_color2.29200510
9MP0005058_abnormal_lysosome_morphology2.23743348
10MP0001299_abnormal_eye_distance/2.19640160
11MP0009840_abnormal_foam_cell2.12629652
12MP0005257_abnormal_intraocular_pressure2.10937257
13MP0002796_impaired_skin_barrier1.98730510
14MP0003890_abnormal_embryonic-extraembry1.96013554
15MP0003453_abnormal_keratinocyte_physiol1.87870923
16MP0008438_abnormal_cutaneous_collagen1.79466837
17MP0000733_abnormal_muscle_development1.77634627
18MP0001958_emphysema1.67198530
19MP0005023_abnormal_wound_healing1.66777794
20MP0009053_abnormal_anal_canal1.62280738
21MP0004185_abnormal_adipocyte_glucose1.62238850
22MP0002877_abnormal_melanocyte_morpholog1.62207700
23MP0010386_abnormal_urinary_bladder1.62175657
24MP0002060_abnormal_skin_morphology1.62025924
25MP0005451_abnormal_body_composition1.61985702
26MP0001849_ear_inflammation1.61534898
27MP0008007_abnormal_cellular_replicative1.61291685
28MP0009379_abnormal_foot_pigmentation1.59759273
29MP0003191_abnormal_cellular_cholesterol1.56642643
30MP0002638_abnormal_pupillary_reflex1.55047954
31MP0010368_abnormal_lymphatic_system1.51690267
32MP0003329_amyloid_beta_deposits1.48729439
33MP0003942_abnormal_urinary_system1.48528148
34MP0003279_aneurysm1.46983503
35MP0005501_abnormal_skin_physiology1.45063813
36MP0005503_abnormal_tendon_morphology1.43718555
37MP0003303_peritoneal_inflammation1.42345544
38MP0003121_genomic_imprinting1.42276063
39MP0003300_gastrointestinal_ulcer1.40417223
40MP0005197_abnormal_uvea_morphology1.40259278
41MP0002177_abnormal_outer_ear1.39820357
42MP0003091_abnormal_cell_migration1.37860829
43MP0000762_abnormal_tongue_morphology1.37045043
44MP0003077_abnormal_cell_cycle1.35595040
45MP0000537_abnormal_urethra_morphology1.34594194
46MP0003172_abnormal_lysosome_physiology1.34105052
47MP0002938_white_spotting1.32058013
48MP0003693_abnormal_embryo_hatching1.30913826
49MP0002751_abnormal_autonomic_nervous1.29401148
50MP0010352_gastrointestinal_tract_polyps1.26753988
51MP0000858_altered_metastatic_potential1.25974376
52MP0009333_abnormal_splenocyte_physiolog1.21423624
53MP0006276_abnormal_autonomic_nervous1.20197887
54MP0002089_abnormal_postnatal_growth/wei1.20056127
55MP0000751_myopathy1.19639607
56MP0000350_abnormal_cell_proliferation1.19391792
57MP0003646_muscle_fatigue1.19354910
58MP0008260_abnormal_autophagy1.17911382
59MP0000534_abnormal_ureter_morphology1.17041877
60MP0004957_abnormal_blastocyst_morpholog1.17034021
61MP0008932_abnormal_embryonic_tissue1.16336034
62MP0010307_abnormal_tumor_latency1.15616061
63MP0000678_abnormal_parathyroid_gland1.15329089
64MP0003385_abnormal_body_wall1.15292624
65MP0009278_abnormal_bone_marrow1.13686984
66MP0000778_abnormal_nervous_system1.13650997
67MP0004883_abnormal_blood_vessel1.12657553
68MP0003950_abnormal_plasma_membrane1.10175433
69MP0001348_abnormal_lacrimal_gland1.09551594
70MP0003755_abnormal_palate_morphology1.09331520
71MP0000566_synostosis1.09321313
72MP0009672_abnormal_birth_weight1.08935161
73MP0003448_altered_tumor_morphology1.08503066
74MP0009250_abnormal_appendicular_skeleto1.07679313
75MP0001915_intracranial_hemorrhage1.06076264
76MP0003705_abnormal_hypodermis_morpholog1.04082764
77MP0000049_abnormal_middle_ear1.03851289
78MP0004233_abnormal_muscle_weight1.03302684
79MP0001730_embryonic_growth_arrest1.01224315
80MP0002085_abnormal_embryonic_tissue1.01116681
81MP0002116_abnormal_craniofacial_bone1.00425311
82MP0004133_heterotaxia1.00180052
83MP0002084_abnormal_developmental_patter0.98780633
84MP0002282_abnormal_trachea_morphology0.98195710
85MP0000462_abnormal_digestive_system0.98064490
86MP0000428_abnormal_craniofacial_morphol0.98039223
87MP0000747_muscle_weakness0.97742159
88MP0001697_abnormal_embryo_size0.97500073
89MP0001216_abnormal_epidermal_layer0.97289975
90MP0000759_abnormal_skeletal_muscle0.96560971
91MP0008789_abnormal_olfactory_epithelium0.96210038
92MP0002697_abnormal_eye_size0.95777649
93MP0004859_abnormal_synaptic_plasticity0.94247792
94MP0004264_abnormal_extraembryonic_tissu0.93940089
95MP0000467_abnormal_esophagus_morphology0.92640138
96MP0004808_abnormal_hematopoietic_stem0.90682146
97MP0005508_abnormal_skeleton_morphology0.90611600
98MP0009384_cardiac_valve_regurgitation0.90245955
99MP0000377_abnormal_hair_follicle0.89681916
100MP0004858_abnormal_nervous_system0.89151624
101MP0005248_abnormal_Harderian_gland0.88866715
102MP0004087_abnormal_muscle_fiber0.88677104
103MP0009780_abnormal_chondrocyte_physiolo0.87725023
104MP0001293_anophthalmia0.87459547
105MP0003861_abnormal_nervous_system0.87414332
106MP0000003_abnormal_adipose_tissue0.84935030
107MP0002113_abnormal_skeleton_development0.84385748
108MP0010630_abnormal_cardiac_muscle0.82206395
109MP0003634_abnormal_glial_cell0.81956760
110MP0002092_abnormal_eye_morphology0.81811568
111MP0002086_abnormal_extraembryonic_tissu0.81678096
112MP0000767_abnormal_smooth_muscle0.81617181
113MP0004510_myositis0.81453751
114MP0004811_abnormal_neuron_physiology0.81166520
115MP0003937_abnormal_limbs/digits/tail_de0.80713922
116MP0005621_abnormal_cell_physiology0.80372313
117MP0003115_abnormal_respiratory_system0.79714373
118MP0002184_abnormal_innervation0.79406869
119MP0005360_urolithiasis0.79231689
120MP0000579_abnormal_nail_morphology0.78964608
121MP0005623_abnormal_meninges_morphology0.78339517
122MP0001243_abnormal_dermal_layer0.76892795
123MP0000750_abnormal_muscle_regeneration0.76760373
124MP0002080_prenatal_lethality0.76715033
125MP0002925_abnormal_cardiovascular_devel0.76643929
126MP0000604_amyloidosis0.75542238
127MP0008961_abnormal_basal_metabolism0.75480485
128MP0003938_abnormal_ear_development0.75368169
129MP0002088_abnormal_embryonic_growth/wei0.75204054
130MP0005390_skeleton_phenotype0.74585749
131MP0003984_embryonic_growth_retardation0.74130449
132MP0005187_abnormal_penis_morphology0.73979729
133MP0003123_paternal_imprinting0.72645118
134MP0002109_abnormal_limb_morphology0.72641852
135MP0002932_abnormal_joint_morphology0.72210533
136MP0005375_adipose_tissue_phenotype0.72132266
137MP0001672_abnormal_embryogenesis/_devel0.72013542
138MP0005380_embryogenesis_phenotype0.72013542
139MP0005275_abnormal_skin_tensile0.71610414
140MP0005666_abnormal_adipose_tissue0.71537127
141MP0002896_abnormal_bone_mineralization0.70021958
142MP0000371_diluted_coat_color0.69782168
143MP0006138_congestive_heart_failure0.69511614
144MP0000538_abnormal_urinary_bladder0.69472587
145MP0005193_abnormal_anterior_eye0.69391042
146MP0003566_abnormal_cell_adhesion0.69293958
147MP0000432_abnormal_head_morphology0.68620756
148MP0002998_abnormal_bone_remodeling0.68605277
149MP0010771_integument_phenotype0.68166128
150MP0005000_abnormal_immune_tolerance0.68140688
151MP0003183_abnormal_peptide_metabolism0.67347423
152MP0003436_decreased_susceptibility_to0.66928584
153MP0002233_abnormal_nose_morphology0.65776219

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)3.04189000
2Hyperacusis (HP:0010780)2.96513806
3Short 4th metacarpal (HP:0010044)2.77439147
4Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.77439147
5Spinal rigidity (HP:0003306)2.70264507
6Achilles tendon contracture (HP:0001771)2.69148843
7Shallow orbits (HP:0000586)2.65399657
8Osteolytic defects of the phalanges of the hand (HP:0009771)2.65307137
9Osteolytic defects of the hand bones (HP:0009699)2.65307137
10Abnormality of the labia minora (HP:0012880)2.60155441
11Papilledema (HP:0001085)2.58841428
12Abnormality of the anterior horn cell (HP:0006802)2.57961143
13Degeneration of anterior horn cells (HP:0002398)2.57961143
14Trigonocephaly (HP:0000243)2.56694315
15Vertebral compression fractures (HP:0002953)2.53221360
16Distal lower limb amyotrophy (HP:0008944)2.51638258
17Fragile skin (HP:0001030)2.49500660
18Wrist flexion contracture (HP:0001239)2.44701246
19Bladder diverticulum (HP:0000015)2.44355153
20Abnormality of the Achilles tendon (HP:0005109)2.40758327
21Insomnia (HP:0100785)2.39188627
22Increased connective tissue (HP:0009025)2.38788238
23Short nail (HP:0001799)2.37820877
24Cortical dysplasia (HP:0002539)2.36723061
25Cervical subluxation (HP:0003308)2.36511521
26Arterial tortuosity (HP:0005116)2.35734671
27Aortic aneurysm (HP:0004942)2.35632462
28Ulnar bowing (HP:0003031)2.34160555
29Vascular tortuosity (HP:0004948)2.33486863
30Distal lower limb muscle weakness (HP:0009053)2.29139674
31Spondylolisthesis (HP:0003302)2.28695609
32Broad face (HP:0000283)2.26270540
33Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.25029885
34Papillary thyroid carcinoma (HP:0002895)2.21204397
35Flat acetabular roof (HP:0003180)2.20475897
36Disproportionate tall stature (HP:0001519)2.19166176
37Increased variability in muscle fiber diameter (HP:0003557)2.17669963
38Distal upper limb amyotrophy (HP:0007149)2.16498615
39Upper limb amyotrophy (HP:0009129)2.16498615
40Asymmetry of the thorax (HP:0001555)2.16428523
41Failure to thrive in infancy (HP:0001531)2.15020312
42Syringomyelia (HP:0003396)2.13927821
43Spinal cord lesions (HP:0100561)2.13927821
44Thin bony cortex (HP:0002753)2.13191385
45Cerebral inclusion bodies (HP:0100314)2.07576033
46Neurofibrillary tangles (HP:0002185)2.07547121
47Hyperparathyroidism (HP:0000843)2.06709104
48Cerebral aneurysm (HP:0004944)2.06144466
49Mildly elevated creatine phosphokinase (HP:0008180)2.05828331
50Mitral valve prolapse (HP:0001634)2.05055288
51Centrally nucleated skeletal muscle fibers (HP:0003687)2.04546255
52Lower limb amyotrophy (HP:0007210)2.02844579
53Abnormality of skeletal muscle fiber size (HP:0012084)2.02590820
54Abnormality of the distal phalanx of the thumb (HP:0009617)2.02097396
55Blue sclerae (HP:0000592)2.00742238
56Narrow palate (HP:0000189)2.00649919
57Aqueductal stenosis (HP:0002410)2.00009584
58Broad metatarsal (HP:0001783)1.98181747
59Ankyloglossia (HP:0010296)1.98134797
60Disinhibition (HP:0000734)1.95489388
61Mitral stenosis (HP:0001718)1.95442033
62Heterochromia iridis (HP:0001100)1.94970355
63Overriding aorta (HP:0002623)1.94471422
64Spinal cord compression (HP:0002176)1.94409316
65Trismus (HP:0000211)1.94277253
66Elbow flexion contracture (HP:0002987)1.94050491
67Type 1 muscle fiber predominance (HP:0003803)1.91661085
68Back pain (HP:0003418)1.90097521
69Abnormality of the distal phalanges of the toes (HP:0010182)1.89949298
70Increased density of long bones (HP:0006392)1.89001673
71Termporal pattern (HP:0011008)1.87733914
72Insidious onset (HP:0003587)1.87733914
73Genu recurvatum (HP:0002816)1.87249296
74Advanced eruption of teeth (HP:0006288)1.87062662
75Hyperextensible skin (HP:0000974)1.85169704
76Peritonitis (HP:0002586)1.85000738
77Limb dystonia (HP:0002451)1.84306951
78Deep palmar crease (HP:0006191)1.84092838
79Abnormal ossification of hand bones (HP:0005921)1.82194774
80Dilatation of the ascending aorta (HP:0005111)1.80938759
81Arnold-Chiari malformation (HP:0002308)1.80919166
82Nasal speech (HP:0001611)1.80705058
83Abnormality of the acetabulum (HP:0003170)1.80467993
84Recurrent abscess formation (HP:0002722)1.80069334
85Aortic dissection (HP:0002647)1.79964515
86Hypoventilation (HP:0002791)1.78968588
87Overgrowth (HP:0001548)1.78923326
88Abnormality of oral frenula (HP:0000190)1.77064570
89Patellar aplasia (HP:0006443)1.77046886
90Generalized amyotrophy (HP:0003700)1.76764612
91Turricephaly (HP:0000262)1.76127381
92Long palpebral fissure (HP:0000637)1.75660696
93Coronal craniosynostosis (HP:0004440)1.75436128
94Broad thumb (HP:0011304)1.74706582
95Abnormal hair whorl (HP:0010721)1.73942132
96Dyschromatopsia (HP:0007641)1.72502954
97Long eyelashes (HP:0000527)1.72311425
98Abnormality of the nasal septum (HP:0000419)1.72180706
99Selective tooth agenesis (HP:0001592)1.71832797
100Joint laxity (HP:0001388)1.71013626
101Hand muscle atrophy (HP:0009130)1.70621410
102Striae distensae (HP:0001065)1.70440249
103Thyroid carcinoma (HP:0002890)1.69457655
104Elfin facies (HP:0004428)1.68171147
105Right ventricular cardiomyopathy (HP:0011663)1.67968923
106Nuclear cataract (HP:0100018)1.67710270
107Spinal muscular atrophy (HP:0007269)1.66584915
108Abnormality of carpal bone ossification (HP:0006257)1.66182866
109Congenital glaucoma (HP:0001087)1.66122578
110Round ear (HP:0100830)1.65932507
111Soft skin (HP:0000977)1.65264039
112Bowel diverticulosis (HP:0005222)1.64895945
113Optic nerve coloboma (HP:0000588)1.63697965
114Aplastic anemia (HP:0001915)1.62297677
115Ankle contracture (HP:0006466)1.61946253
116Natal tooth (HP:0000695)1.61923632
117Neonatal short-limb short stature (HP:0008921)1.60403217
118Broad ribs (HP:0000885)1.60394943
119Deviation of the hallux (HP:0010051)1.60259274
120Hypercalcemia (HP:0003072)1.60088844
121Eczematoid dermatitis (HP:0000976)1.59454101
122Aplasia/Hypoplasia of the patella (HP:0006498)1.59443325
123Hallux valgus (HP:0001822)1.59089835
124Difficulty climbing stairs (HP:0003551)1.58698252
125Chronic obstructive pulmonary disease (HP:0006510)1.58407737
126Obstructive lung disease (HP:0006536)1.58407737
127Mediastinal lymphadenopathy (HP:0100721)1.58381918
128Deviation of the thumb (HP:0009603)1.57933920
129Bony spicule pigmentary retinopathy (HP:0007737)1.57872267
130Patellar dislocation (HP:0002999)1.56916673
131Macroorchidism (HP:0000053)1.56628376
132Bilateral sensorineural hearing impairment (HP:0008619)1.56230071
133Abnormality of the umbilical cord (HP:0010881)1.55698462
134Volvulus (HP:0002580)1.55698316
135Premature rupture of membranes (HP:0001788)1.55584744
136Wormian bones (HP:0002645)1.55264133
137Mitral regurgitation (HP:0001653)1.54479065
138Biconcave vertebral bodies (HP:0004586)1.54320313
139Abnormality of the 4th metacarpal (HP:0010012)1.54182674
140Broad phalanges of the hand (HP:0009768)1.54053550
141Delayed closure of the anterior fontanelle (HP:0001476)1.53525722
142Abnormality of the aortic arch (HP:0012303)1.52001650
143Renal duplication (HP:0000075)1.51433009
144Persistence of primary teeth (HP:0006335)1.50407724
145Aneurysm (HP:0002617)1.49450932
146Abnormality of liposaccharide metabolism (HP:0010968)1.49374927
147Abnormality of glycosphingolipid metabolism (HP:0004343)1.49374927
148Abnormality of glycolipid metabolism (HP:0010969)1.49374927
149Hypoplasia of the maxilla (HP:0000327)1.49344169
150Obstructive sleep apnea (HP:0002870)1.48985228
151Axonal loss (HP:0003447)1.48305547
152Abnormality of the phalanges of the hallux (HP:0010057)1.47709270
153Relative macrocephaly (HP:0004482)1.47491211
154Adducted thumb (HP:0001181)1.46336319
155Flared iliac wings (HP:0002869)1.46175359
156Agnosia (HP:0010524)1.45703537
157Atrophy/Degeneration involving motor neurons (HP:0007373)1.44991831
158Anal stenosis (HP:0002025)1.44861888
159Leiomyosarcoma (HP:0100243)1.44387221
160Uterine leiomyosarcoma (HP:0002891)1.44387221
161Proximal placement of thumb (HP:0009623)1.44123771
162Abnormality of the radial head (HP:0003995)1.43905393
163Spinal canal stenosis (HP:0003416)1.43495491
164Broad toe (HP:0001837)1.43105293
165Fused cervical vertebrae (HP:0002949)1.42926338
166Dysostosis multiplex (HP:0000943)1.41806743
167Aseptic necrosis (HP:0010885)1.41772700
168Abnormality of dentin (HP:0010299)1.41580942
169Bladder carcinoma (HP:0002862)1.40841351
170Bladder neoplasm (HP:0009725)1.40841351
171Broad finger (HP:0001500)1.40512687
172Atrophic scars (HP:0001075)1.40384467
173Protruding ear (HP:0000411)1.39733207
174Ulnar claw (HP:0001178)1.39230881
175Delayed cranial suture closure (HP:0000270)1.39049326

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK37.06453309
2KSR12.91937051
3IRAK32.88514640
4LIMK12.82834920
5BCR2.63966140
6ICK2.60022602
7LATS12.58550471
8NEK12.52579118
9EEF2K2.49571570
10SMG12.48689453
11EPHB22.37931466
12LATS22.33034451
13CDC72.31784389
14TESK12.22146997
15MINK12.06677946
16ACVR1B2.03796363
17EPHA21.95023918
18NTRK11.80825677
19DMPK1.73179016
20BLK1.73042881
21MAP3K121.70253917
22MST1R1.68113779
23ERBB31.65754150
24LMTK21.64519684
25PKN21.62927246
26ERN11.61594248
27ARAF1.55967836
28STK101.52967370
29SCYL21.50707115
30TESK21.50568227
31CDK121.45530809
32UHMK11.45396669
33MET1.39350893
34MAP3K91.30521319
35TAOK21.30203806
36PRKD31.28243938
37PDGFRA1.27517925
38BRSK21.25702215
39PAK41.15906371
40FGFR41.14851162
41PRKG21.11050228
42DYRK21.09292723
43RPS6KA41.08302491
44CDK181.07519818
45NTRK21.05317296
46PTK61.02297423
47NEK21.01952270
48MARK31.00377033
49PLK30.99921832
50NME20.99452526
51LRRK20.99153672
52ADRBK10.98217630
53BRSK10.97018641
54STK30.94819852
55CDK140.91742022
56SIK20.91171913
57PRPF4B0.89239686
58TYRO30.89104323
59MAP3K130.86990243
60MOS0.83272025
61EIF2AK10.82972726
62FGFR10.82963576
63NEK90.82533995
64MAP3K60.81662942
65PIM20.80793751
66MELK0.80692077
67PAK60.79531210
68CDC42BPA0.78853336
69PLK20.78700033
70MAP2K30.78369176
71MAP3K50.78227724
72BUB10.78210859
73MYLK0.77269062
74STK240.75688077
75RPS6KA20.74646959
76CDK150.73581058
77CDK80.73542610
78MAP3K10.72640257
79DYRK1B0.72240915
80RPS6KB20.69861607
81TGFBR20.67882395
82IRAK20.67731872
83MAP3K30.66663226
84PAK10.66605620
85BRAF0.66094777
86TTK0.65971685
87DDR20.65253771
88ATR0.65030231
89TTN0.64959143
90CHUK0.64108473
91PDPK10.63469730
92ABL20.63412566
93MAP3K20.63217535
94SIK10.62713093
95MARK10.62157772
96CAMK1G0.61993027
97MAP3K80.61392959
98PBK0.59508638
99PLK10.59251635
100CDK11A0.58557102
101ERBB20.58383875
102STK160.57866391
103MAP3K100.57687794
104JAK30.53933678
105AKT20.53645128
106EPHB10.52994077
107EIF2AK20.52380303
108CSNK1G20.50862352
109PRKD20.50772830
110FGFR20.50527584
111TRIB30.49867244
112KSR20.49610187
113CDK60.49511829
114STK380.49044621
115DAPK30.48625163
116MKNK10.48335172
117BMPR1B0.47777440
118IRAK40.47211091
119PTK20.47165710
120AURKA0.47124330
121ROCK10.46882840
122KIT0.44791373
123TGFBR10.44273531
124CAMK1D0.44153977
125PDGFRB0.42810304
126ROCK20.42316440
127ERBB40.41441738
128RET0.40716408
129BMX0.39898414
130MAPKAPK20.39132361
131MTOR0.37271457
132ILK0.36402022
133CSNK1G30.35832973
134MAP2K20.35678785
135RIPK10.35163665
136CDK70.35082598
137MARK20.34823733
138MAP3K110.34799777
139SGK30.34185719
140FGFR30.33010148
141HIPK20.32762457
142CHEK20.31715845
143PAK20.31155790
144MAP2K10.30912125
145CAMK2G0.28820161
146TAF10.27542989

Predicted pathways (KEGG)

RankGene SetZ-score
1Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.23264547
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.97817392
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.96659429
4Central carbon metabolism in cancer_Homo sapiens_hsa052301.85871095
5Other glycan degradation_Homo sapiens_hsa005111.81603668
6Vitamin B6 metabolism_Homo sapiens_hsa007501.78561691
7ECM-receptor interaction_Homo sapiens_hsa045121.74678852
8Prion diseases_Homo sapiens_hsa050201.72945481
9Pentose phosphate pathway_Homo sapiens_hsa000301.68506094
10Cell cycle_Homo sapiens_hsa041101.66194094
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.63431142
12Leishmaniasis_Homo sapiens_hsa051401.62273892
13Phototransduction_Homo sapiens_hsa047441.56971459
14Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.56217190
15Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.50381144
16Adherens junction_Homo sapiens_hsa045201.49430681
17Phagosome_Homo sapiens_hsa041451.43277976
18Galactose metabolism_Homo sapiens_hsa000521.43146694
19Colorectal cancer_Homo sapiens_hsa052101.43028649
20Shigellosis_Homo sapiens_hsa051311.39813758
21Chronic myeloid leukemia_Homo sapiens_hsa052201.36750369
22TGF-beta signaling pathway_Homo sapiens_hsa043501.34589652
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.33761819
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.32982365
25Hippo signaling pathway_Homo sapiens_hsa043901.29449042
26Biosynthesis of amino acids_Homo sapiens_hsa012301.27260697
27Viral myocarditis_Homo sapiens_hsa054161.26476671
28Pancreatic cancer_Homo sapiens_hsa052121.26367340
29Neurotrophin signaling pathway_Homo sapiens_hsa047221.25854408
30MicroRNAs in cancer_Homo sapiens_hsa052061.22226074
31Legionellosis_Homo sapiens_hsa051341.21785888
32Proteoglycans in cancer_Homo sapiens_hsa052051.16589963
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.13732086
34Hepatitis B_Homo sapiens_hsa051611.13680147
35Salmonella infection_Homo sapiens_hsa051321.13237832
36Spliceosome_Homo sapiens_hsa030401.12271647
37Tuberculosis_Homo sapiens_hsa051521.11484855
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.10074590
39Fructose and mannose metabolism_Homo sapiens_hsa000511.08960178
40p53 signaling pathway_Homo sapiens_hsa041151.08926370
41Apoptosis_Homo sapiens_hsa042101.08711293
42Graft-versus-host disease_Homo sapiens_hsa053321.08271976
43Glioma_Homo sapiens_hsa052141.06780413
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.06553300
45Endometrial cancer_Homo sapiens_hsa052131.05006852
46mTOR signaling pathway_Homo sapiens_hsa041501.04080702
47HTLV-I infection_Homo sapiens_hsa051661.03145096
48Insulin signaling pathway_Homo sapiens_hsa049101.02247470
49Basal cell carcinoma_Homo sapiens_hsa052171.01044372
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.00478601
51Epstein-Barr virus infection_Homo sapiens_hsa051690.99167314
52Acute myeloid leukemia_Homo sapiens_hsa052210.98948099
53Osteoclast differentiation_Homo sapiens_hsa043800.98629611
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98415597
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97727790
56Vibrio cholerae infection_Homo sapiens_hsa051100.97474238
57Tight junction_Homo sapiens_hsa045300.97289409
58RNA transport_Homo sapiens_hsa030130.97128086
59VEGF signaling pathway_Homo sapiens_hsa043700.96455203
60Notch signaling pathway_Homo sapiens_hsa043300.96142574
61Oocyte meiosis_Homo sapiens_hsa041140.95632223
62GnRH signaling pathway_Homo sapiens_hsa049120.94512142
63TNF signaling pathway_Homo sapiens_hsa046680.94191013
64Axon guidance_Homo sapiens_hsa043600.93500986
65Renal cell carcinoma_Homo sapiens_hsa052110.93343217
66Pertussis_Homo sapiens_hsa051330.93151937
67Wnt signaling pathway_Homo sapiens_hsa043100.92844716
68Lysosome_Homo sapiens_hsa041420.89985278
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.89589659
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89302581
71Estrogen signaling pathway_Homo sapiens_hsa049150.89278579
72Small cell lung cancer_Homo sapiens_hsa052220.88792138
73Carbon metabolism_Homo sapiens_hsa012000.88682998
74Melanoma_Homo sapiens_hsa052180.88373932
75Glycosaminoglycan degradation_Homo sapiens_hsa005310.87825219
76Type I diabetes mellitus_Homo sapiens_hsa049400.87693708
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.85905916
78Rheumatoid arthritis_Homo sapiens_hsa053230.85550068
79Protein digestion and absorption_Homo sapiens_hsa049740.84022444
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82920284
81Synaptic vesicle cycle_Homo sapiens_hsa047210.82474573
82Pathways in cancer_Homo sapiens_hsa052000.81040341
83Viral carcinogenesis_Homo sapiens_hsa052030.81033781
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80698534
85Toxoplasmosis_Homo sapiens_hsa051450.80610125
86Melanogenesis_Homo sapiens_hsa049160.80444836
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79983063
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78947583
89Non-small cell lung cancer_Homo sapiens_hsa052230.78892667
90ErbB signaling pathway_Homo sapiens_hsa040120.78418171
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78267556
92Proteasome_Homo sapiens_hsa030500.77701485
93* Endocytosis_Homo sapiens_hsa041440.77146024
94Focal adhesion_Homo sapiens_hsa045100.77137270
95Thyroid cancer_Homo sapiens_hsa052160.76933204
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76878825
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.75693297
98Base excision repair_Homo sapiens_hsa034100.74283570
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73494531
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.73455034
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.73449254
102HIF-1 signaling pathway_Homo sapiens_hsa040660.72255909
103AMPK signaling pathway_Homo sapiens_hsa041520.72019043
104Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.71930495
105Dopaminergic synapse_Homo sapiens_hsa047280.71760228
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71059341
107Prostate cancer_Homo sapiens_hsa052150.70795366
108Chemokine signaling pathway_Homo sapiens_hsa040620.70245575
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69400023
110DNA replication_Homo sapiens_hsa030300.69097254
111Long-term potentiation_Homo sapiens_hsa047200.69095090
112Dilated cardiomyopathy_Homo sapiens_hsa054140.69033242
113Bladder cancer_Homo sapiens_hsa052190.67468601
114Gap junction_Homo sapiens_hsa045400.67468275
115Inositol phosphate metabolism_Homo sapiens_hsa005620.66973260
116Cyanoamino acid metabolism_Homo sapiens_hsa004600.66703835
117Hedgehog signaling pathway_Homo sapiens_hsa043400.66301567
118Malaria_Homo sapiens_hsa051440.65768067
119Influenza A_Homo sapiens_hsa051640.65338563
120Amoebiasis_Homo sapiens_hsa051460.65241044
121Measles_Homo sapiens_hsa051620.65024873
122Herpes simplex infection_Homo sapiens_hsa051680.64598320
123MAPK signaling pathway_Homo sapiens_hsa040100.63895600
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63660432
125Arginine biosynthesis_Homo sapiens_hsa002200.63162739
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62651120
127mRNA surveillance pathway_Homo sapiens_hsa030150.62413613
128PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62304561
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.62270040
130Asthma_Homo sapiens_hsa053100.62245720
131Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62063129
132Prolactin signaling pathway_Homo sapiens_hsa049170.61699096
133T cell receptor signaling pathway_Homo sapiens_hsa046600.61389590
134Cholinergic synapse_Homo sapiens_hsa047250.61160677
135Rap1 signaling pathway_Homo sapiens_hsa040150.58919876
136Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56794428
137Hepatitis C_Homo sapiens_hsa051600.56309471
138N-Glycan biosynthesis_Homo sapiens_hsa005100.55137866
139Choline metabolism in cancer_Homo sapiens_hsa052310.53551109
140Thyroid hormone synthesis_Homo sapiens_hsa049180.53488214
141Sphingolipid metabolism_Homo sapiens_hsa006000.52072252
142Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51005764
143Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47700110
144Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47512634

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