SNX13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.25875129
2protein K11-linked deubiquitination (GO:0035871)3.89753561
3monoubiquitinated protein deubiquitination (GO:0035520)3.84195420
4protein localization to Golgi apparatus (GO:0034067)3.48901555
5Golgi to endosome transport (GO:0006895)3.46711516
6locomotory exploration behavior (GO:0035641)3.41052611
7phospholipid translocation (GO:0045332)3.36020526
8lipid translocation (GO:0034204)3.36020526
9negative regulation of complement activation (GO:0045916)3.34463545
10neural tube formation (GO:0001841)3.32099773
11iron ion import (GO:0097286)3.18359870
12nuclear pore complex assembly (GO:0051292)3.12361866
13regulation of short-term neuronal synaptic plasticity (GO:0048172)3.07254658
14intra-Golgi vesicle-mediated transport (GO:0006891)3.06590079
15regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.06180740
16regulation of establishment of cell polarity (GO:2000114)3.03969903
17regulation of pigment cell differentiation (GO:0050932)3.03435650
18synaptic vesicle maturation (GO:0016188)3.03289221
19negative regulation of protein activation cascade (GO:2000258)2.99472796
20genitalia morphogenesis (GO:0035112)2.96260283
21protein targeting to lysosome (GO:0006622)2.95494621
22establishment of protein localization to vacuole (GO:0072666)2.95494621
23protein targeting to vacuole (GO:0006623)2.95494621
24early endosome to late endosome transport (GO:0045022)2.89721525
25cell wall macromolecule catabolic process (GO:0016998)2.87869499
26glomerular visceral epithelial cell development (GO:0072015)2.87526028
27cytoplasmic mRNA processing body assembly (GO:0033962)2.85906091
28cellular potassium ion homeostasis (GO:0030007)2.85728282
29protein K48-linked deubiquitination (GO:0071108)2.85014050
30cilium or flagellum-dependent cell motility (GO:0001539)2.84007369
31nucleus localization (GO:0051647)2.82088748
32regulation of relaxation of muscle (GO:1901077)2.78809118
33glutamate secretion (GO:0014047)2.76979218
34sodium ion export (GO:0071436)2.74811460
35activation of protein kinase A activity (GO:0034199)2.73041200
36regulation of protein glycosylation (GO:0060049)2.72824537
37prostate gland growth (GO:0060736)2.69457479
38proline transport (GO:0015824)2.68151259
39nuclear pore organization (GO:0006999)2.68057837
40regulation of establishment or maintenance of cell polarity (GO:0032878)2.66421683
41prenylation (GO:0097354)2.66373825
42protein prenylation (GO:0018342)2.66373825
43regulation of ARF protein signal transduction (GO:0032012)2.63506097
44histone mRNA catabolic process (GO:0071044)2.61599844
45negative regulation of neurotransmitter transport (GO:0051589)2.61557408
46cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.61007415
47negative regulation of sodium ion transport (GO:0010766)2.60949415
48microtubule anchoring (GO:0034453)2.58611573
49protein localization to endosome (GO:0036010)2.57872355
50regulation of Rac protein signal transduction (GO:0035020)2.56708308
51cell wall macromolecule metabolic process (GO:0044036)2.55911191
52regulation of synaptic vesicle exocytosis (GO:2000300)2.55063189
53glomerular epithelial cell development (GO:0072310)2.54999818
54positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.53653015
55negative regulation of neurotransmitter secretion (GO:0046929)2.53041396
56myelin assembly (GO:0032288)2.52892678
57protein targeting to Golgi (GO:0000042)2.52268236
58negative regulation of cytosolic calcium ion concentration (GO:0051481)2.50363310
59regulation of hexokinase activity (GO:1903299)2.50030846
60regulation of glucokinase activity (GO:0033131)2.50030846
61interleukin-6-mediated signaling pathway (GO:0070102)2.45551760
62interkinetic nuclear migration (GO:0022027)2.45053386
63macroautophagy (GO:0016236)2.44714784
64vocalization behavior (GO:0071625)2.44304694
65establishment of protein localization to Golgi (GO:0072600)2.41847649
66regulation of centriole replication (GO:0046599)2.41115952
67retrograde transport, vesicle recycling within Golgi (GO:0000301)2.40119794
68positive regulation of insulin receptor signaling pathway (GO:0046628)2.39891702
69cytoskeletal anchoring at plasma membrane (GO:0007016)2.39083458
70potassium ion import (GO:0010107)2.39032315
71dorsal/ventral axis specification (GO:0009950)2.37659561
72establishment of nucleus localization (GO:0040023)2.37018315
73positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.36670215
74vesicle transport along microtubule (GO:0047496)2.36349479
75positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.35238819
76fibroblast migration (GO:0010761)2.34821912
77dendrite morphogenesis (GO:0048813)2.34774447
78central nervous system neuron axonogenesis (GO:0021955)2.33710904
79positive regulation of mitotic sister chromatid separation (GO:1901970)2.33305254
80positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.33305254
81positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.33305254
82layer formation in cerebral cortex (GO:0021819)2.33267579
83epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.32849779
84regulation of synapse structural plasticity (GO:0051823)2.31269289
85fatty acid transmembrane transport (GO:1902001)2.31239901
86nerve growth factor signaling pathway (GO:0038180)2.30636835
87synaptic vesicle exocytosis (GO:0016079)2.30359275
88pericardium development (GO:0060039)2.29484273
89UDP-N-acetylglucosamine metabolic process (GO:0006047)2.29456442
90innervation (GO:0060384)2.29007856
91positive regulation of vascular permeability (GO:0043117)2.28654700
92carnitine shuttle (GO:0006853)2.27323009
93negative regulation of humoral immune response (GO:0002921)2.26561593
94regulation of protein polyubiquitination (GO:1902914)2.26344814
95regulation of cell communication by electrical coupling (GO:0010649)2.26324271
96relaxation of cardiac muscle (GO:0055119)2.25581857
97cellular response to sterol (GO:0036315)2.25283850
98alpha-linolenic acid metabolic process (GO:0036109)2.25164317
99cyclic nucleotide catabolic process (GO:0009214)2.25054994
100dicarboxylic acid biosynthetic process (GO:0043650)2.24788880
101negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.24765314
102exploration behavior (GO:0035640)2.24414750
103NLS-bearing protein import into nucleus (GO:0006607)2.22477453
104growth hormone receptor signaling pathway (GO:0060396)2.22310163
105embryonic retina morphogenesis in camera-type eye (GO:0060059)2.21903618
106protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.21873204
107synaptic vesicle docking involved in exocytosis (GO:0016081)2.21673613
108cell communication by electrical coupling (GO:0010644)2.21516326
109regulation of clathrin-mediated endocytosis (GO:2000369)2.21174397
110positive regulation of muscle hypertrophy (GO:0014742)2.21096178
111positive regulation of cardiac muscle hypertrophy (GO:0010613)2.21096178
112regulation of energy homeostasis (GO:2000505)2.20736346
113positive regulation of protein autophosphorylation (GO:0031954)2.20499620
114mitotic sister chromatid cohesion (GO:0007064)2.20277392
115regulation of synaptic vesicle transport (GO:1902803)2.19951012
116acrosome assembly (GO:0001675)2.18955877
117response to lipoprotein particle (GO:0055094)2.18640975
118negative regulation of hormone biosynthetic process (GO:0032353)2.17284758
119plasma membrane repair (GO:0001778)2.16827206
120protein K63-linked deubiquitination (GO:0070536)2.16708068
121positive regulation of Rab GTPase activity (GO:0032851)2.16402377
122regulation of Rab GTPase activity (GO:0032313)2.16402377
123alanine transport (GO:0032328)2.14082436
124cAMP catabolic process (GO:0006198)2.13975307
125membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.13690945
126pore complex assembly (GO:0046931)2.13559834
127membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.13516342
128negative regulation of keratinocyte proliferation (GO:0010839)2.13030252
129cellular sodium ion homeostasis (GO:0006883)2.12960287
130COPII vesicle coating (GO:0048208)2.12841835
131regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.12309995
132neuronal action potential propagation (GO:0019227)2.11645567
133acrosome reaction (GO:0007340)2.10268390
134cell communication involved in cardiac conduction (GO:0086065)2.10123172
135cellular ketone body metabolic process (GO:0046950)2.09181057
136phospholipid homeostasis (GO:0055091)2.07156209
137neurotransmitter secretion (GO:0007269)2.03386531
138regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.03285602
139ionotropic glutamate receptor signaling pathway (GO:0035235)2.03201071
140positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.03185457
141regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.01351324
142clathrin coat assembly (GO:0048268)2.00104472
143negative regulation of potassium ion transmembrane transporter activity (GO:1901017)1.97999112
144positive regulation of glycolytic process (GO:0045821)1.97155015
145positive regulation of fatty acid beta-oxidation (GO:0032000)1.96253721
146cerebellar Purkinje cell differentiation (GO:0021702)1.94690253
147gamma-aminobutyric acid transport (GO:0015812)1.94286432
148erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)1.94110115
149L-phenylalanine catabolic process (GO:0006559)1.94110115
150intracellular lipid transport (GO:0032365)1.93977132
151apoptotic cell clearance (GO:0043277)1.91970594
152neuromuscular process controlling balance (GO:0050885)1.91895211
153endoplasmic reticulum organization (GO:0007029)1.91614889
154regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)1.91557400
155long-term synaptic potentiation (GO:0060291)1.91374298
156membrane repolarization during action potential (GO:0086011)1.90837048
157lysine metabolic process (GO:0006553)1.89874982
158lysine catabolic process (GO:0006554)1.89874982
159regulation of glutamate receptor signaling pathway (GO:1900449)1.89370904
160regulation of long-term neuronal synaptic plasticity (GO:0048169)1.89157709
161positive regulation of potassium ion transport (GO:0043268)1.88007662
162ketone body metabolic process (GO:1902224)1.87422922
163stress fiber assembly (GO:0043149)1.86898178
164membrane repolarization (GO:0086009)1.86828671
165positive regulation of calcium ion transmembrane transporter activity (GO:1901021)1.86165284
166long-term memory (GO:0007616)1.86107286
167glutamate receptor signaling pathway (GO:0007215)1.85535023
168positive regulation of axon extension (GO:0045773)1.84772361
169regulation of vascular endothelial growth factor signaling pathway (GO:1900746)1.84613170
170regulation of dendritic spine morphogenesis (GO:0061001)1.83941474
171insulin-like growth factor receptor signaling pathway (GO:0048009)1.83621015
172cellular response to ethanol (GO:0071361)1.83577662
173organelle transport along microtubule (GO:0072384)1.83113505
174regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act1.83033773
175neurotransmitter-gated ion channel clustering (GO:0072578)1.82702671
176sarcoplasmic reticulum calcium ion transport (GO:0070296)1.81381993
177cerebellar granule cell differentiation (GO:0021707)1.80693900
178potassium ion homeostasis (GO:0055075)1.80567748
179regulation of neuronal synaptic plasticity (GO:0048168)1.80540251
180positive regulation of potassium ion transmembrane transport (GO:1901381)1.80146622
181negative regulation of potassium ion transmembrane transport (GO:1901380)1.80058211

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human3.04420981
2ZFP57_27257070_Chip-Seq_ESCs_Mouse2.45277155
3EZH2_22144423_ChIP-Seq_EOC_Human2.33991977
4FUS_26573619_Chip-Seq_HEK293_Human2.16483162
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.15126268
6GBX2_23144817_ChIP-Seq_PC3_Human2.13994700
7CDX2_19796622_ChIP-Seq_MESCs_Mouse2.11852862
8FLI1_27457419_Chip-Seq_LIVER_Mouse1.96269769
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.96096853
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.83386222
11ER_23166858_ChIP-Seq_MCF-7_Human1.83274055
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80702770
13DROSHA_22980978_ChIP-Seq_HELA_Human1.79531695
14ZNF217_24962896_ChIP-Seq_MCF-7_Human1.77268279
15MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.76969816
16PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74802939
17SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.73333514
18* LXR_22158963_ChIP-Seq_LIVER_Mouse1.69519237
19MTF2_20144788_ChIP-Seq_MESCs_Mouse1.68520529
20ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.65469078
21ESR1_20079471_ChIP-ChIP_T-47D_Human1.64501013
22IGF1R_20145208_ChIP-Seq_DFB_Human1.64034889
23TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.62937794
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.60528295
25SUZ12_27294783_Chip-Seq_NPCs_Mouse1.60206399
26TRIM28_21343339_ChIP-Seq_HEK293_Human1.59897202
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.59255091
28EZH2_27294783_Chip-Seq_NPCs_Mouse1.58952326
29EWS_26573619_Chip-Seq_HEK293_Human1.58335115
30VDR_22108803_ChIP-Seq_LS180_Human1.57741163
31UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57485145
32SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.57337490
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57008038
34NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.55775600
35EZH2_18974828_ChIP-Seq_MESCs_Mouse1.55683886
36RNF2_18974828_ChIP-Seq_MESCs_Mouse1.55683886
37TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.54258756
38CBP_20019798_ChIP-Seq_JUKART_Human1.54122791
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54122791
40NANOG_18555785_Chip-Seq_ESCs_Mouse1.53861211
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.53191903
42EP300_21415370_ChIP-Seq_HL-1_Mouse1.51932419
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51618632
44RXR_22158963_ChIP-Seq_LIVER_Mouse1.51082480
45FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.50124094
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.48022412
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45764312
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45261612
49FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.44427710
50* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.42708347
51* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.42708347
52BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.42522583
53CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.42472924
54JARID2_20064375_ChIP-Seq_MESCs_Mouse1.41811928
55CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.41718907
56* SMAD4_21799915_ChIP-Seq_A2780_Human1.40479466
57CDX2_22108803_ChIP-Seq_LS180_Human1.40284925
58AHR_22903824_ChIP-Seq_MCF-7_Human1.39550829
59SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.38537241
60AR_21572438_ChIP-Seq_LNCaP_Human1.38135749
61E2F1_18555785_Chip-Seq_ESCs_Mouse1.37806663
62ARNT_22903824_ChIP-Seq_MCF-7_Human1.37326839
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.36285389
64EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.34726062
65FOXA2_19822575_ChIP-Seq_HepG2_Human1.32026246
66* RARB_27405468_Chip-Seq_BRAIN_Mouse1.30894358
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30488551
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28575333
69* FLI1_21867929_ChIP-Seq_TH2_Mouse1.28561700
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28121479
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28121479
72NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26908140
73JARID2_20075857_ChIP-Seq_MESCs_Mouse1.26875901
74P53_22387025_ChIP-Seq_ESCs_Mouse1.25143119
75* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.24605079
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24017108
77BCAT_22108803_ChIP-Seq_LS180_Human1.23350775
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23191033
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23089096
80ESR2_21235772_ChIP-Seq_MCF-7_Human1.22944446
81TP53_16413492_ChIP-PET_HCT116_Human1.21742400
82RXR_22108803_ChIP-Seq_LS180_Human1.21561039
83CMYC_18555785_Chip-Seq_ESCs_Mouse1.21373211
84SUZ12_18555785_Chip-Seq_ESCs_Mouse1.21015714
85TCF4_22108803_ChIP-Seq_LS180_Human1.21003076
86CRX_20693478_ChIP-Seq_RETINA_Mouse1.20869244
87* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20639718
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19653093
89RUNX2_22187159_ChIP-Seq_PCA_Human1.19627298
90* SOX2_21211035_ChIP-Seq_LN229_Gbm1.19379395
91OCT4_21477851_ChIP-Seq_ESCs_Mouse1.18237560
92* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.18114267
93WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17342186
94KDM2B_26808549_Chip-Seq_REH_Human1.17232493
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17034455
96* STAT3_23295773_ChIP-Seq_U87_Human1.16015116
97Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.15357054
98EED_16625203_ChIP-ChIP_MESCs_Mouse1.15249552
99P300_18555785_Chip-Seq_ESCs_Mouse1.13823712
100FOXO3_23340844_ChIP-Seq_DLD1_Human1.13044942
101RNF2_27304074_Chip-Seq_ESCs_Mouse1.12642101
102EZH2_27294783_Chip-Seq_ESCs_Mouse1.12052751
103CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11458664
104CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11292664
105GATA1_22025678_ChIP-Seq_K562_Human1.11260479
106* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.10863560
107SMAD4_21741376_ChIP-Seq_EPCs_Human1.10748312
108EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10604513
109BRD4_25478319_ChIP-Seq_HGPS_Human1.10580711
110RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10159623
111SUZ12_27294783_Chip-Seq_ESCs_Mouse1.09159627
112TP53_18474530_ChIP-ChIP_U2OS_Human1.09039139
113SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.08807826
114CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08620094
115SMAD3_21741376_ChIP-Seq_EPCs_Human1.07216611
116* PRDM14_20953172_ChIP-Seq_ESCs_Human1.07193826
117VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07109114
118GATA2_21666600_ChIP-Seq_HMVEC_Human1.05449180
119CJUN_26792858_Chip-Seq_BT549_Human1.05022977
120AR_25329375_ChIP-Seq_VCAP_Human1.04734570
121WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04155828
122ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03782631
123FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.03539541
124REST_21632747_ChIP-Seq_MESCs_Mouse1.03249428
125POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02316739
126* AR_19668381_ChIP-Seq_PC3_Human1.01974675
127NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.01714014
128P300_19829295_ChIP-Seq_ESCs_Human1.01230652
129TAF15_26573619_Chip-Seq_HEK293_Human1.00855726
130SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00226439
131ZNF274_21170338_ChIP-Seq_K562_Hela0.99060720
132PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98275337
133* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98222603
134EZH2_27304074_Chip-Seq_ESCs_Mouse0.98142877
135AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.97663276
136* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96513386
137CLOCK_20551151_ChIP-Seq_293T_Human0.96163181
138TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94586892
139* TCF4_23295773_ChIP-Seq_U87_Human0.93918930
140* SMAD4_21741376_ChIP-Seq_HESCs_Human0.91737662
141ESR1_21235772_ChIP-Seq_MCF-7_Human0.91364393
142BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91226242
143SMAD3_21741376_ChIP-Seq_HESCs_Human0.90974659
144CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89253716
145* TP63_23658742_ChIP-Seq_EP156T_Human0.89105102
146YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88989337
147TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87912978
148FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87761263
149TCF4_18268006_ChIP-ChIP_LS174T_Human0.86954591
150PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85418159
151TBX20_22328084_ChIP-Seq_HEART_Mouse0.83654263
152TBX20_22080862_ChIP-Seq_HEART_Mouse0.83654263

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.39352209
2MP0004859_abnormal_synaptic_plasticity3.65334058
3MP0010678_abnormal_skin_adnexa3.04800295
4MP0009780_abnormal_chondrocyte_physiolo2.91576218
5MP0010352_gastrointestinal_tract_polyps2.72632348
6MP0000427_abnormal_hair_cycle2.71941507
7MP0000383_abnormal_hair_follicle2.68909978
8MP0005248_abnormal_Harderian_gland2.61259819
9MP0002139_abnormal_hepatobiliary_system2.60584240
10MP0002009_preneoplasia2.36563669
11MP0010234_abnormal_vibrissa_follicle2.27611400
12MP0004130_abnormal_muscle_cell2.26620149
13MP0004270_analgesia2.26272187
14MP0005360_urolithiasis2.26058620
15MP0003950_abnormal_plasma_membrane2.13852573
16MP0003252_abnormal_bile_duct2.12670838
17MP0003300_gastrointestinal_ulcer2.12098985
18MP0003635_abnormal_synaptic_transmissio2.09470599
19MP0005085_abnormal_gallbladder_physiolo2.05272842
20MP0004858_abnormal_nervous_system2.05139774
21MP0005365_abnormal_bile_salt2.01103935
22MP0003690_abnormal_glial_cell1.99574502
23MP0000013_abnormal_adipose_tissue1.97591524
24MP0002837_dystrophic_cardiac_calcinosis1.97442404
25MP0002102_abnormal_ear_morphology1.95528417
26MP0002909_abnormal_adrenal_gland1.88721554
27MP0003646_muscle_fatigue1.86889589
28MP0003329_amyloid_beta_deposits1.80372981
29MP0005408_hypopigmentation1.77781446
30MP0001984_abnormal_olfaction1.77579058
31MP0000569_abnormal_digit_pigmentation1.74247180
32MP0009697_abnormal_copulation1.74043388
33MP0006054_spinal_hemorrhage1.72589142
34MP0003890_abnormal_embryonic-extraembry1.67959642
35MP0008875_abnormal_xenobiotic_pharmacok1.67456158
36MP0000604_amyloidosis1.64470986
37MP0003656_abnormal_erythrocyte_physiolo1.60391561
38MP0004145_abnormal_muscle_electrophysio1.60116526
39MP0002063_abnormal_learning/memory/cond1.58998084
40MP0003705_abnormal_hypodermis_morpholog1.58766361
41MP0000751_myopathy1.53880809
42MP0005174_abnormal_tail_pigmentation1.53822634
43MP0009745_abnormal_behavioral_response1.52031619
44MP0005058_abnormal_lysosome_morphology1.51757831
45MP0000747_muscle_weakness1.49373934
46MP0002064_seizures1.47930744
47MP0004036_abnormal_muscle_relaxation1.46954498
48MP0010329_abnormal_lipoprotein_level1.46365389
49MP0003183_abnormal_peptide_metabolism1.42323562
50MP0003191_abnormal_cellular_cholesterol1.41956822
51MP0003195_calcinosis1.41824579
52MP0009046_muscle_twitch1.39909598
53MP0008438_abnormal_cutaneous_collagen1.39627578
54MP0001666_abnormal_nutrient_absorption1.38265276
55MP0005367_renal/urinary_system_phenotyp1.37487462
56MP0000516_abnormal_urinary_system1.37487462
57MP0005167_abnormal_blood-brain_barrier1.36542198
58MP0003075_altered_response_to1.35537244
59MP0003303_peritoneal_inflammation1.35468847
60MP0003045_fibrosis1.34104388
61MP0003633_abnormal_nervous_system1.30920756
62MP0000015_abnormal_ear_pigmentation1.30596332
63MP0004043_abnormal_pH_regulation1.29005142
64MP0005253_abnormal_eye_physiology1.25627469
65MP0000920_abnormal_myelination1.25048117
66MP0008877_abnormal_DNA_methylation1.24959636
67MP0005409_darkened_coat_color1.22302567
68MP0005410_abnormal_fertilization1.20847729
69MP0001661_extended_life_span1.20152344
70MP0002118_abnormal_lipid_homeostasis1.20041643
71MP0000749_muscle_degeneration1.19808055
72MP0003941_abnormal_skin_development1.18766384
73MP0001299_abnormal_eye_distance/1.18037551
74MP0001958_emphysema1.17906516
75MP0004215_abnormal_myocardial_fiber1.17395387
76MP0004510_myositis1.17176581
77MP0002572_abnormal_emotion/affect_behav1.14927470
78MP0003787_abnormal_imprinting1.13656938
79MP0003937_abnormal_limbs/digits/tail_de1.13092299
80MP0003172_abnormal_lysosome_physiology1.12596402
81MP0004084_abnormal_cardiac_muscle1.12526789
82MP0002734_abnormal_mechanical_nocicepti1.12439410
83MP0001486_abnormal_startle_reflex1.10744503
84MP0004264_abnormal_extraembryonic_tissu1.10283051
85MP0001968_abnormal_touch/_nociception1.10024030
86MP0004087_abnormal_muscle_fiber1.08133048
87MP0010368_abnormal_lymphatic_system1.08065941
88MP0004885_abnormal_endolymph1.06770888
89MP0004233_abnormal_muscle_weight1.06156531
90MP0004185_abnormal_adipocyte_glucose1.05871499
91MP0001177_atelectasis1.05177092
92MP0005451_abnormal_body_composition1.05035493
93MP0000371_diluted_coat_color1.04910705
94MP0003632_abnormal_nervous_system1.04534423
95MP0001440_abnormal_grooming_behavior1.03770653
96MP0002166_altered_tumor_susceptibility1.03169090
97MP0005171_absent_coat_pigmentation1.02324931
98MP0002090_abnormal_vision1.02139985
99MP0002272_abnormal_nervous_system1.01941713
100MP0009384_cardiac_valve_regurgitation1.01373372
101MP0005620_abnormal_muscle_contractility1.01091232
102MP0002138_abnormal_hepatobiliary_system1.00448719
103MP0005332_abnormal_amino_acid0.99891609
104MP0005535_abnormal_body_temperature0.99006741
105MP0002295_abnormal_pulmonary_circulatio0.97886813
106MP0002067_abnormal_sensory_capabilities0.97880367
107MP0004484_altered_response_of0.97599863
108MP0003868_abnormal_feces_composition0.97251043
109MP0002108_abnormal_muscle_morphology0.97118753
110MP0003631_nervous_system_phenotype0.95668821
111MP0003634_abnormal_glial_cell0.95505867
112MP0002896_abnormal_bone_mineralization0.94612090
113MP0002332_abnormal_exercise_endurance0.94548511
114MP0005666_abnormal_adipose_tissue0.93911867
115MP0002971_abnormal_brown_adipose0.93392885
116MP0005551_abnormal_eye_electrophysiolog0.93162694
117MP0005623_abnormal_meninges_morphology0.92563316
118MP0008569_lethality_at_weaning0.92380309
119MP0010307_abnormal_tumor_latency0.92091277
120MP0005083_abnormal_biliary_tract0.90334262
121MP0000647_abnormal_sebaceous_gland0.90328435
122MP0001501_abnormal_sleep_pattern0.90269301
123MP0005275_abnormal_skin_tensile0.89563936
124MP0008961_abnormal_basal_metabolism0.88941942
125MP0002733_abnormal_thermal_nociception0.87892773
126MP0005187_abnormal_penis_morphology0.87731949
127MP0000003_abnormal_adipose_tissue0.87536129
128MP0005386_behavior/neurological_phenoty0.87127631
129MP0004924_abnormal_behavior0.87127631
130MP0005310_abnormal_salivary_gland0.86964061
131MP0002168_other_aberrant_phenotype0.86376823
132MP0004085_abnormal_heartbeat0.86215961
133MP0005647_abnormal_sex_gland0.85888560
134MP0002269_muscular_atrophy0.85336020
135MP0002972_abnormal_cardiac_muscle0.84883531
136MP0004134_abnormal_chest_morphology0.84570025
137MP0002006_tumorigenesis0.83925116
138MP0005584_abnormal_enzyme/coenzyme_acti0.83125170
139MP0009840_abnormal_foam_cell0.82756197
140MP0003091_abnormal_cell_migration0.82281663
141MP0005166_decreased_susceptibility_to0.81956160
142MP0002078_abnormal_glucose_homeostasis0.81459742
143MP0005395_other_phenotype0.80332744
144MP0001485_abnormal_pinna_reflex0.80257728
145MP0008874_decreased_physiological_sensi0.79965011
146MP0005375_adipose_tissue_phenotype0.79790874
147MP0004272_abnormal_basement_membrane0.79373790
148MP0001879_abnormal_lymphatic_vessel0.78188376
149MP0003935_abnormal_craniofacial_develop0.77655877
150MP0002928_abnormal_bile_duct0.74935941
151MP0009115_abnormal_fat_cell0.74794924
152MP0000428_abnormal_craniofacial_morphol0.73742939
153MP0003221_abnormal_cardiomyocyte_apopto0.71102347
154MP0002638_abnormal_pupillary_reflex0.70651264
155MP0010386_abnormal_urinary_bladder0.69732096
156MP0005220_abnormal_exocrine_pancreas0.68515138
157MP0005266_abnormal_metabolism0.67200163
158MP0009703_decreased_birth_body0.65691664
159MP0001324_abnormal_eye_pigmentation0.65253393
160MP0000432_abnormal_head_morphology0.64094845
161MP0004883_abnormal_blood_vessel0.63067378
162MP0002127_abnormal_cardiovascular_syste0.62460681
163MP0003828_pulmonary_edema0.61936659
164MP0002233_abnormal_nose_morphology0.61691461

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)4.36849911
2Action tremor (HP:0002345)3.28728202
3Tubulointerstitial nephritis (HP:0001970)3.12804150
4Thyroid carcinoma (HP:0002890)3.03568348
5Chronic hepatic failure (HP:0100626)3.03491931
6Fair hair (HP:0002286)2.95845548
7Deep venous thrombosis (HP:0002625)2.82487626
8Gaze-evoked nystagmus (HP:0000640)2.82277257
9Abnormality of the left ventricular outflow tract (HP:0011103)2.76947270
10Subaortic stenosis (HP:0001682)2.76947270
11Focal motor seizures (HP:0011153)2.64162680
12Exercise-induced myalgia (HP:0003738)2.61090565
13Neurofibrillary tangles (HP:0002185)2.59530630
14Aplasia/Hypoplasia of the tibia (HP:0005772)2.56413314
15Cerebral inclusion bodies (HP:0100314)2.48696071
16Curly hair (HP:0002212)2.48381970
17Insidious onset (HP:0003587)2.47928087
18Termporal pattern (HP:0011008)2.47928087
19Hypoplastic labia majora (HP:0000059)2.47677775
20Focal seizures (HP:0007359)2.46188612
21Visual hallucinations (HP:0002367)2.46044190
22Complement deficiency (HP:0004431)2.44644667
23Intention tremor (HP:0002080)2.40313720
24Hyporeflexia of lower limbs (HP:0002600)2.39753168
25Supranuclear gaze palsy (HP:0000605)2.37076971
26Ketoacidosis (HP:0001993)2.36457351
27Abnormality of the labia majora (HP:0012881)2.36157622
28Arterial tortuosity (HP:0005116)2.35846781
29Generalized hypopigmentation of hair (HP:0011358)2.32237891
30Widely spaced teeth (HP:0000687)2.27114833
31Cerebral aneurysm (HP:0004944)2.26125905
32Retinal atrophy (HP:0001105)2.25685590
33Vascular tortuosity (HP:0004948)2.24069050
34Myokymia (HP:0002411)2.20959846
35Pancreatic cysts (HP:0001737)2.20897673
36Pancreatic fibrosis (HP:0100732)2.18851470
37Postural instability (HP:0002172)2.16848944
38Macroorchidism (HP:0000053)2.15882969
39Aqueductal stenosis (HP:0002410)2.15666698
40Atonic seizures (HP:0010819)2.15594742
41Truncal obesity (HP:0001956)2.15311940
42Abnormal biliary tract morphology (HP:0012440)2.15309520
43Overgrowth (HP:0001548)2.15148342
44Cystic hygroma (HP:0000476)2.14004938
45Biliary tract neoplasm (HP:0100574)2.13368350
46Abnormality of the renal cortex (HP:0011035)2.13139537
47Long clavicles (HP:0000890)2.08314073
48Exercise-induced muscle cramps (HP:0003710)2.06943138
49Febrile seizures (HP:0002373)2.06352966
50Mitral stenosis (HP:0001718)2.06328261
51Menstrual irregularities (HP:0000858)2.04966618
52Thyroiditis (HP:0100646)2.03700065
53Dysdiadochokinesis (HP:0002075)2.03547635
54Hypoglycemic coma (HP:0001325)2.02858686
55Tubulointerstitial abnormality (HP:0001969)2.02560934
56Aortic aneurysm (HP:0004942)2.01955943
57Xanthomatosis (HP:0000991)2.01912484
58Ketosis (HP:0001946)1.99293702
59Dysmetric saccades (HP:0000641)1.97469185
60Large earlobe (HP:0009748)1.96990923
61Difficulty running (HP:0009046)1.96301452
62Subacute progressive viral hepatitis (HP:0006572)1.95493915
63Progressive cerebellar ataxia (HP:0002073)1.95308939
64Epidermoid cyst (HP:0200040)1.95185320
65Hamartoma of the eye (HP:0010568)1.94808902
66Calf muscle hypertrophy (HP:0008981)1.94327618
67Muscle hypertrophy of the lower extremities (HP:0008968)1.93850028
68Absence seizures (HP:0002121)1.93435670
69Volvulus (HP:0002580)1.92820603
70Intestinal atresia (HP:0011100)1.92395811
71Resting tremor (HP:0002322)1.92182795
72Hepatoblastoma (HP:0002884)1.90902347
73Central scotoma (HP:0000603)1.90715119
74Abnormality of potassium homeostasis (HP:0011042)1.90386445
75Hypoalphalipoproteinemia (HP:0003233)1.90082639
76Genital tract atresia (HP:0001827)1.90058263
77Buphthalmos (HP:0000557)1.89907926
78Broad metatarsal (HP:0001783)1.89841300
79Scanning speech (HP:0002168)1.89487710
80Type 1 muscle fiber predominance (HP:0003803)1.88272439
81Dysmetria (HP:0001310)1.86653751
82Short tibia (HP:0005736)1.86443469
83Ankle clonus (HP:0011448)1.86419906
84Absent speech (HP:0001344)1.85307122
85Abnormal auditory evoked potentials (HP:0006958)1.85243385
86Transitional cell carcinoma of the bladder (HP:0006740)1.84861218
87Urinary bladder sphincter dysfunction (HP:0002839)1.84668199
88Insulin-resistant diabetes mellitus (HP:0000831)1.84522761
89Skin nodule (HP:0200036)1.84254146
90Hematochezia (HP:0002573)1.83014900
91Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.82170419
92Protuberant abdomen (HP:0001538)1.81981806
93Impaired social interactions (HP:0000735)1.81887528
94Abnormal social behavior (HP:0012433)1.81887528
95Generalized tonic-clonic seizures (HP:0002069)1.81217516
96Bundle branch block (HP:0011710)1.80614679
97Bladder carcinoma (HP:0002862)1.80285718
98Bladder neoplasm (HP:0009725)1.80285718
99Frequent falls (HP:0002359)1.79593693
100Neuroendocrine neoplasm (HP:0100634)1.78782080
101Dysostosis multiplex (HP:0000943)1.78697435
102Impaired vibration sensation in the lower limbs (HP:0002166)1.78613288
103Increased CSF protein (HP:0002922)1.78390914
104Decreased lacrimation (HP:0000633)1.78242300
105Intrahepatic cholestasis (HP:0001406)1.78144825
106Sensorimotor neuropathy (HP:0007141)1.77478855
107Depression (HP:0000716)1.77312427
108Aplasia/Hypoplasia of the tongue (HP:0010295)1.75412549
109Hip dysplasia (HP:0001385)1.75397013
110Hypoplastic ischia (HP:0003175)1.75168324
111Excessive salivation (HP:0003781)1.74902005
112Drooling (HP:0002307)1.74902005
113Tubular atrophy (HP:0000092)1.74463262
114Postural tremor (HP:0002174)1.74450315
115Sandal gap (HP:0001852)1.74234721
116Abnormality of the calf musculature (HP:0001430)1.73403122
117Papilledema (HP:0001085)1.73389903
118Hyperkalemia (HP:0002153)1.73246213
119Hamartoma (HP:0010566)1.72754850
120Breast carcinoma (HP:0003002)1.72563155
121Mitral valve prolapse (HP:0001634)1.72023947
122Hyperglycemia (HP:0003074)1.71797199
123Sudden death (HP:0001699)1.71517685
124Dynein arm defect of respiratory motile cilia (HP:0012255)1.70697977
125Absent/shortened dynein arms (HP:0200106)1.70697977
126Mucopolysacchariduria (HP:0008155)1.70550553
127Urinary glycosaminoglycan excretion (HP:0003541)1.70550553
128True hermaphroditism (HP:0010459)1.70455971
129Poor coordination (HP:0002370)1.70414587
130Cerebellar dysplasia (HP:0007033)1.69808724
131Narrow palate (HP:0000189)1.69209683
132Pheochromocytoma (HP:0002666)1.69180749
133Neoplasm of the small intestine (HP:0100833)1.68856885
134Myoglobinuria (HP:0002913)1.68012978
135Abnormality of the lower motor neuron (HP:0002366)1.67934286
136Blue irides (HP:0000635)1.66799922
137Asymmetric septal hypertrophy (HP:0001670)1.66615138
138Furrowed tongue (HP:0000221)1.66526469
139Ventricular fibrillation (HP:0001663)1.66061319
140Abnormality of the ischium (HP:0003174)1.65340087
141Turricephaly (HP:0000262)1.65263214
142Abnormal ciliary motility (HP:0012262)1.64795624
143Hyperventilation (HP:0002883)1.64603217
144Cone-rod dystrophy (HP:0000548)1.64573014
145Aneurysm (HP:0002617)1.64227599
146Status epilepticus (HP:0002133)1.63390049
147Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.63154494
148Scotoma (HP:0000575)1.62998563
149Nemaline bodies (HP:0003798)1.62739397
150Gout (HP:0001997)1.62678048
151Poor eye contact (HP:0000817)1.62646249
152Focal segmental glomerulosclerosis (HP:0000097)1.61936263
153Syncope (HP:0001279)1.61721460
154Abnormality of the intrinsic pathway (HP:0010989)1.61300898
155Muscle fiber inclusion bodies (HP:0100299)1.61194975
156Vaginal atresia (HP:0000148)1.61184863
157Abnormality of the common coagulation pathway (HP:0010990)1.60857468
158Increased cerebral lipofuscin (HP:0011813)1.60526429
159Increased variability in muscle fiber diameter (HP:0003557)1.60427250
160Dialeptic seizures (HP:0011146)1.60258242
161Glomerulonephritis (HP:0000099)1.60004191
162Abnormality of the renal medulla (HP:0100957)1.59725852
163Hyperlipoproteinemia (HP:0010980)1.59686919
164Acute myeloid leukemia (HP:0004808)1.59685342
165Torticollis (HP:0000473)1.59541713
166Urinary urgency (HP:0000012)1.59313737
167Downturned corners of mouth (HP:0002714)1.59033038
168Right ventricular cardiomyopathy (HP:0011663)1.59016879
169Metaphyseal dysplasia (HP:0100255)1.58022551
170Hypothermia (HP:0002045)1.57932992
171Abnormality of the astrocytes (HP:0100707)1.57695952
172Astrocytoma (HP:0009592)1.57695952
173Abnormality of the Achilles tendon (HP:0005109)1.57591535
174Abnormality of glutamine family amino acid metabolism (HP:0010902)1.57515946
175Submucous cleft hard palate (HP:0000176)1.57488548
176Lymphangioma (HP:0100764)1.57163605
177Glioma (HP:0009733)1.56658549
178Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.54874808
179Pulmonic stenosis (HP:0001642)1.54293725

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT32.89839728
2MAP3K92.66279778
3ACVR1B2.60266695
4STK38L2.41710156
5FRK2.21956452
6NTRK32.13074928
7KSR22.04599206
8ERBB32.03927029
9CAMK1G1.93756450
10EPHA41.87969498
11MAP3K21.82287977
12MAP3K41.75955528
13BRD41.75462657
14STK391.74092337
15CASK1.73179642
16RIPK41.71382523
17NTRK11.65606596
18CAMKK11.63894117
19DAPK21.62774549
20TRIB31.61956964
21RIPK11.60566508
22CAMK1D1.59922577
23TTN1.57889227
24PAK61.57162769
25PIK3CA1.56311941
26PHKG21.55354195
27PHKG11.55354195
28NLK1.53865792
29TRIM281.52960751
30BRSK21.52904553
31LMTK21.52857642
32BMPR1B1.44198972
33PAK31.42329403
34PNCK1.42320126
35OXSR11.41207315
36TNIK1.37899053
37SCYL21.37885940
38MAP2K41.36988082
39CAMKK21.35941774
40TGFBR21.32856819
41STK31.32775581
42TRPM71.30358132
43PDK31.30356284
44PDK41.30356284
45MARK11.30158969
46DMPK1.29388351
47WNK11.25704216
48FGFR21.24658155
49MKNK21.24332110
50KSR11.23117785
51EPHA31.22000731
52WNK41.21932555
53INSRR1.20215982
54LATS11.19436560
55FER1.18823630
56NEK91.17394759
57NUAK11.17248850
58YES11.17032416
59RET1.17016438
60ERN11.17004733
61NEK61.16391102
62MINK11.16340498
63SGK31.15540548
64SIK11.15368804
65PRKD31.13980690
66PTK61.13677627
67PDPK11.11881159
68PDK11.11165091
69WNK31.06284995
70EIF2AK31.04779660
71PDGFRA1.03961884
72PKN21.02554030
73JAK11.02159083
74PRKCH1.01469285
75SGK21.00599275
76PLK40.98439735
77BCR0.95947377
78SGK2230.95467250
79SGK4940.95467250
80MAP3K130.95419124
81TAOK30.93970297
82MST40.93894290
83PDK20.91632973
84STK380.90477284
85PINK10.90435800
86MAP3K70.88642603
87CDK50.86069389
88STK240.84752173
89MAPK130.83847976
90IRAK10.82478410
91FGFR10.79560699
92PDGFRB0.76368391
93EPHB10.76091724
94STK110.74488919
95PLK20.72267925
96TYRO30.72254655
97PTK20.72219626
98OBSCN0.70545073
99CSNK1G20.70143017
100MELK0.69063182
101PTK2B0.68825217
102SGK10.67189969
103FES0.64711275
104BLK0.62411628
105MAP2K70.61740583
106PKN10.61440857
107MAP3K120.61252867
108DDR20.60983604
109JAK20.60500133
110MAP4K20.59789372
111PIK3CG0.59685025
112PRKAA20.58583036
113FGFR30.56519652
114PRKD10.54653006
115MAP2K10.54425756
116BMPR20.53916551
117FYN0.53795589
118CAMK2A0.52426055
119TAOK10.52113660
120MST1R0.51776218
121PRKAA10.51583744
122CAMK2D0.51183722
123ROCK10.50875282
124PRKCE0.49781825
125MAPK120.49580700
126PRKCG0.49435932
127CSNK1G10.48373503
128MET0.47726431
129ERBB20.47639073
130CSNK1A1L0.47413601
131PRKCQ0.46842594
132ERBB40.46358571
133MKNK10.44750028
134MAP3K10.44653507
135PBK0.43724784
136CAMK2G0.42632543
137CAMK2B0.41920545
138CAMK40.41754628
139CAMK10.41191951
140RPS6KB10.41078572
141EGFR0.34927642
142PRKACB0.33944048
143PRKG10.33587610
144MYLK0.30589121
145FGR0.30155264
146ATM0.27683371

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.05518522
2Circadian rhythm_Homo sapiens_hsa047102.07013731
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.63885954
4Inositol phosphate metabolism_Homo sapiens_hsa005621.56115452
5Adherens junction_Homo sapiens_hsa045201.49205326
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.45805113
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.41720955
8Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.41092344
9Long-term potentiation_Homo sapiens_hsa047201.40384684
10Arginine biosynthesis_Homo sapiens_hsa002201.39742106
11Maturity onset diabetes of the young_Homo sapiens_hsa049501.34434290
12Bile secretion_Homo sapiens_hsa049761.32607751
13Circadian entrainment_Homo sapiens_hsa047131.30166998
14Salivary secretion_Homo sapiens_hsa049701.30130389
15Gastric acid secretion_Homo sapiens_hsa049711.27319297
16Renin secretion_Homo sapiens_hsa049241.24768674
17Insulin secretion_Homo sapiens_hsa049111.24440292
18Synaptic vesicle cycle_Homo sapiens_hsa047211.21633423
19Sulfur metabolism_Homo sapiens_hsa009201.20518099
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.20253744
21FoxO signaling pathway_Homo sapiens_hsa040681.20012408
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.18215768
23Glutamatergic synapse_Homo sapiens_hsa047241.17656462
24Fatty acid degradation_Homo sapiens_hsa000711.17540188
25Type II diabetes mellitus_Homo sapiens_hsa049301.16239240
26Endometrial cancer_Homo sapiens_hsa052131.15814233
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.14547055
28GABAergic synapse_Homo sapiens_hsa047271.12153731
29Lysine degradation_Homo sapiens_hsa003101.11739178
30Olfactory transduction_Homo sapiens_hsa047401.09897782
31TGF-beta signaling pathway_Homo sapiens_hsa043501.09109975
32Butanoate metabolism_Homo sapiens_hsa006501.08669276
33PPAR signaling pathway_Homo sapiens_hsa033201.08356052
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.08308426
35Amphetamine addiction_Homo sapiens_hsa050311.06243257
36Propanoate metabolism_Homo sapiens_hsa006401.05141981
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.01883708
38Dorso-ventral axis formation_Homo sapiens_hsa043201.00255698
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00143422
40Oxytocin signaling pathway_Homo sapiens_hsa049210.99857415
41Nicotine addiction_Homo sapiens_hsa050330.99480743
42Fatty acid metabolism_Homo sapiens_hsa012120.98518939
43Cholinergic synapse_Homo sapiens_hsa047250.98430991
44Morphine addiction_Homo sapiens_hsa050320.96522670
45Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96089989
46Regulation of autophagy_Homo sapiens_hsa041400.95910604
47Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94743437
48Dilated cardiomyopathy_Homo sapiens_hsa054140.94622074
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.94043534
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.92247292
51Dopaminergic synapse_Homo sapiens_hsa047280.92155680
52Complement and coagulation cascades_Homo sapiens_hsa046100.91970159
53Sphingolipid metabolism_Homo sapiens_hsa006000.91627954
54Thyroid hormone synthesis_Homo sapiens_hsa049180.91399225
55Prolactin signaling pathway_Homo sapiens_hsa049170.90104589
56Prostate cancer_Homo sapiens_hsa052150.89765772
57Long-term depression_Homo sapiens_hsa047300.89534609
58Tight junction_Homo sapiens_hsa045300.88738483
59Estrogen signaling pathway_Homo sapiens_hsa049150.86235249
60Non-homologous end-joining_Homo sapiens_hsa034500.85795952
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85561299
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85221470
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84909102
64cAMP signaling pathway_Homo sapiens_hsa040240.83695187
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82318365
66GnRH signaling pathway_Homo sapiens_hsa049120.81128628
67Insulin resistance_Homo sapiens_hsa049310.81032933
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80844922
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.80214983
70Pancreatic secretion_Homo sapiens_hsa049720.79753224
71Starch and sucrose metabolism_Homo sapiens_hsa005000.79383985
72Melanoma_Homo sapiens_hsa052180.79054338
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78392714
74Glucagon signaling pathway_Homo sapiens_hsa049220.78302475
75Proteoglycans in cancer_Homo sapiens_hsa052050.78197199
76Calcium signaling pathway_Homo sapiens_hsa040200.78129838
77Caffeine metabolism_Homo sapiens_hsa002320.78057514
78Glioma_Homo sapiens_hsa052140.77402088
79MicroRNAs in cancer_Homo sapiens_hsa052060.76569370
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76516549
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76389045
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74847999
83Staphylococcus aureus infection_Homo sapiens_hsa051500.74263737
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.74237454
85Fatty acid biosynthesis_Homo sapiens_hsa000610.72270034
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71688686
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71610082
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70806595
89beta-Alanine metabolism_Homo sapiens_hsa004100.70309852
90Gap junction_Homo sapiens_hsa045400.69227948
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.68981235
92Tryptophan metabolism_Homo sapiens_hsa003800.68631146
93Focal adhesion_Homo sapiens_hsa045100.67243338
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65829142
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.65261681
96Cocaine addiction_Homo sapiens_hsa050300.64869761
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64614284
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64135760
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.64101571
1002-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61603288
101Amoebiasis_Homo sapiens_hsa051460.61288971
102Mineral absorption_Homo sapiens_hsa049780.61153875
103Prion diseases_Homo sapiens_hsa050200.60723562
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60445083
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60346765
106Renal cell carcinoma_Homo sapiens_hsa052110.59874741
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.59256101
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58212099
109ErbB signaling pathway_Homo sapiens_hsa040120.58148547
110Insulin signaling pathway_Homo sapiens_hsa049100.57828295
111Lysosome_Homo sapiens_hsa041420.57711920
112Hedgehog signaling pathway_Homo sapiens_hsa043400.57434894
113Jak-STAT signaling pathway_Homo sapiens_hsa046300.56266057
114ABC transporters_Homo sapiens_hsa020100.55611823
115Glycerolipid metabolism_Homo sapiens_hsa005610.55466622
116Axon guidance_Homo sapiens_hsa043600.55100636
117Ether lipid metabolism_Homo sapiens_hsa005650.54362449
118Taste transduction_Homo sapiens_hsa047420.54234243
119mTOR signaling pathway_Homo sapiens_hsa041500.53715735
120Non-small cell lung cancer_Homo sapiens_hsa052230.53517032
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.53337043
122Renin-angiotensin system_Homo sapiens_hsa046140.53174574
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52556132
124Choline metabolism in cancer_Homo sapiens_hsa052310.51986934
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51681602
126Hippo signaling pathway_Homo sapiens_hsa043900.51483375
127Pyruvate metabolism_Homo sapiens_hsa006200.50174018
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50147897
129Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49680146
130Endocytosis_Homo sapiens_hsa041440.48367415
131Serotonergic synapse_Homo sapiens_hsa047260.48097302
132Platelet activation_Homo sapiens_hsa046110.47528821
133Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47362702
134Ovarian steroidogenesis_Homo sapiens_hsa049130.46257303
135AMPK signaling pathway_Homo sapiens_hsa041520.45327345
136ECM-receptor interaction_Homo sapiens_hsa045120.45111513

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »