SNX14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the sorting nexin family. Members of this family have a phox (PX) phosphoinositide binding domain and are involved in intracellular trafficking. The encoded protein also contains a regulator of G protein signaling (RGS) domain. Regulator of G protein signaling family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. Alternate splicing results in transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1UDP-N-acetylglucosamine metabolic process (GO:0006047)3.90255840
2detection of calcium ion (GO:0005513)3.66582661
3signal peptide processing (GO:0006465)3.62058455
4regulation of protein glycosylation (GO:0060049)3.43086851
5presynaptic membrane assembly (GO:0097105)3.40096482
6neuron cell-cell adhesion (GO:0007158)3.37869664
7regulation of short-term neuronal synaptic plasticity (GO:0048172)3.31012387
8membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.29022916
9COPII vesicle coating (GO:0048208)3.28993367
10regulation of memory T cell differentiation (GO:0043380)3.25100594
11Golgi to endosome transport (GO:0006895)3.25091801
12neuronal action potential propagation (GO:0019227)3.21680918
13regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.19987314
14negative regulation of complement activation (GO:0045916)3.15960851
15negative regulation of protein activation cascade (GO:2000258)3.15347527
16regulation of synaptic vesicle exocytosis (GO:2000300)3.14894934
17phospholipid translocation (GO:0045332)3.13587686
18lipid translocation (GO:0034204)3.13587686
19negative regulation of synaptic transmission, GABAergic (GO:0032229)3.11116093
20protein K11-linked deubiquitination (GO:0035871)3.09184134
21cilium or flagellum-dependent cell motility (GO:0001539)3.08282302
22protein targeting to vacuole (GO:0006623)3.07844997
23protein targeting to lysosome (GO:0006622)3.07844997
24establishment of protein localization to vacuole (GO:0072666)3.07844997
25cellular response to ethanol (GO:0071361)3.06489998
26cellular ketone body metabolic process (GO:0046950)3.05162791
27presynaptic membrane organization (GO:0097090)3.03736490
28positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.03444312
29response to pheromone (GO:0019236)3.03058713
30regulation of beta-amyloid formation (GO:1902003)3.02073327
31nucleotide transmembrane transport (GO:1901679)2.95070650
32activation of protein kinase A activity (GO:0034199)2.94881566
33cellular potassium ion homeostasis (GO:0030007)2.94836379
34glutamate secretion (GO:0014047)2.89310451
35intra-Golgi vesicle-mediated transport (GO:0006891)2.88863473
36response to lipoprotein particle (GO:0055094)2.86854838
37vocalization behavior (GO:0071625)2.86364378
38synaptic vesicle exocytosis (GO:0016079)2.85693684
39startle response (GO:0001964)2.84675232
40postsynaptic membrane organization (GO:0001941)2.80735832
41protein targeting to Golgi (GO:0000042)2.80463341
42ER overload response (GO:0006983)2.79611085
43interleukin-6-mediated signaling pathway (GO:0070102)2.79009234
44indole-containing compound catabolic process (GO:0042436)2.77700594
45indolalkylamine catabolic process (GO:0046218)2.77700594
46tryptophan catabolic process (GO:0006569)2.77700594
47regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.76755445
48regulation of establishment of cell polarity (GO:2000114)2.76467877
49interkinetic nuclear migration (GO:0022027)2.75991736
50regulation of synaptic vesicle transport (GO:1902803)2.73579328
51S-adenosylmethionine metabolic process (GO:0046500)2.72450619
52ketone body metabolic process (GO:1902224)2.72421884
53synaptic transmission, glutamatergic (GO:0035249)2.72382848
54long-term synaptic potentiation (GO:0060291)2.72344715
55cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.71726485
56response to auditory stimulus (GO:0010996)2.69795414
57photoreceptor cell maintenance (GO:0045494)2.69051655
58neurotransmitter-gated ion channel clustering (GO:0072578)2.68501896
59neuron-neuron synaptic transmission (GO:0007270)2.66858964
60glycine transport (GO:0015816)2.66077690
61ionotropic glutamate receptor signaling pathway (GO:0035235)2.65956910
62negative regulation of humoral immune response (GO:0002921)2.65087457
63neural tube formation (GO:0001841)2.65014274
64synaptic vesicle endocytosis (GO:0048488)2.64776221
65magnesium ion transport (GO:0015693)2.64628922
66zinc ion transport (GO:0006829)2.64614197
67positive regulation of glycoprotein biosynthetic process (GO:0010560)2.64537252
68positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.64081094
69sensory perception of smell (GO:0007608)2.63302722
70drug transmembrane transport (GO:0006855)2.62519918
71relaxation of cardiac muscle (GO:0055119)2.61919345
72xenobiotic catabolic process (GO:0042178)2.61562953
73regulation of cytokine production involved in inflammatory response (GO:1900015)2.60474227
74mechanosensory behavior (GO:0007638)2.59914385
75auditory behavior (GO:0031223)2.59606190
76positive regulation of glycolytic process (GO:0045821)2.59430431
77synaptic vesicle maturation (GO:0016188)2.59121709
78synaptic vesicle docking involved in exocytosis (GO:0016081)2.58250492
79regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.57858326
80retrograde transport, vesicle recycling within Golgi (GO:0000301)2.57138441
81membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.56989254
82L-fucose metabolic process (GO:0042354)2.56918793
83L-fucose catabolic process (GO:0042355)2.56918793
84fucose catabolic process (GO:0019317)2.56918793
85transmission of nerve impulse (GO:0019226)2.55690474
86regulation of glutamate receptor signaling pathway (GO:1900449)2.55640917
87bile acid biosynthetic process (GO:0006699)2.55294697
88regulation of glucokinase activity (GO:0033131)2.54540000
89regulation of hexokinase activity (GO:1903299)2.54540000
90DNA double-strand break processing (GO:0000729)2.53931134
91locomotory exploration behavior (GO:0035641)2.53130553
92glutamate receptor signaling pathway (GO:0007215)2.52927141
93tryptophan metabolic process (GO:0006568)2.51136310
94proline transport (GO:0015824)2.50721963
95gamma-aminobutyric acid signaling pathway (GO:0007214)2.49907904
96response to nitrosative stress (GO:0051409)2.49141372
97regulation of Rac protein signal transduction (GO:0035020)2.49107050
98regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.48483178
99establishment of protein localization to Golgi (GO:0072600)2.48244474
100cell adhesion mediated by integrin (GO:0033627)2.47995643
101drug catabolic process (GO:0042737)2.47359292
102alanine transport (GO:0032328)2.47332312
103cholesterol efflux (GO:0033344)2.47148300
104phospholipid homeostasis (GO:0055091)2.47094988
105transepithelial transport (GO:0070633)2.46902171
106glycoprotein catabolic process (GO:0006516)2.45592127
107positive regulation of glycoprotein metabolic process (GO:1903020)2.45496943
108female mating behavior (GO:0060180)2.45105410
109regulation of respiratory system process (GO:0044065)2.44508248
110positive regulation of protein autophosphorylation (GO:0031954)2.44240036
111regulation of synaptic transmission, glutamatergic (GO:0051966)2.43596239
112insulin secretion (GO:0030073)2.43501217
113benzene-containing compound metabolic process (GO:0042537)2.43476164
114macroautophagy (GO:0016236)2.42765773
115positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.42092600
116neurotransmitter secretion (GO:0007269)2.42003600
117epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.41570011
118early endosome to late endosome transport (GO:0045022)2.40686982
119sphingoid metabolic process (GO:0046519)2.40543897
120regulation of amyloid precursor protein catabolic process (GO:1902991)2.38581498
121cAMP catabolic process (GO:0006198)2.37749622
122axonal fasciculation (GO:0007413)2.36958016
123cyclic nucleotide catabolic process (GO:0009214)2.36701430
124negative regulation of cytosolic calcium ion concentration (GO:0051481)2.36332728
125innervation (GO:0060384)2.35107640
126cell communication by electrical coupling (GO:0010644)2.35049982
127regulation of long-term neuronal synaptic plasticity (GO:0048169)2.34550078
128axoneme assembly (GO:0035082)2.34098221
129very-low-density lipoprotein particle assembly (GO:0034379)2.33275745
130protein localization to synapse (GO:0035418)2.32973100
131phenylpropanoid metabolic process (GO:0009698)2.31792797
132righting reflex (GO:0060013)2.31734377
133detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.31619820
134positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.31558115
135branched-chain amino acid catabolic process (GO:0009083)2.30743140
136left/right axis specification (GO:0070986)2.30710793
137protein localization to cilium (GO:0061512)2.30500686
138membrane repolarization during action potential (GO:0086011)2.30148246
139regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.29894672
140regulation of female receptivity (GO:0045924)2.29603121
141bile acid metabolic process (GO:0008206)2.29350573
142regulation of neuronal synaptic plasticity (GO:0048168)2.28910231
143phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.28014018
144thyroid hormone metabolic process (GO:0042403)2.27535578
145mRNA modification (GO:0016556)2.27464279
146retinal rod cell development (GO:0046548)2.27249109
147regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.27068978
148cilium organization (GO:0044782)2.27055615
149membrane depolarization during action potential (GO:0086010)2.26592631
150regulation of establishment or maintenance of cell polarity (GO:0032878)2.26457062
151regulation of neurotransmitter secretion (GO:0046928)2.25652246
152phosphatidylethanolamine metabolic process (GO:0046337)2.25569864
153cellular response to ATP (GO:0071318)2.25322151
154long-term memory (GO:0007616)2.24947850
155phosphorelay signal transduction system (GO:0000160)2.24402887
156adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.23699261
157cAMP metabolic process (GO:0046058)2.23696516
158regulation of excitatory postsynaptic membrane potential (GO:0060079)2.23650014
159cilium morphogenesis (GO:0060271)2.23591816
160G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.23464296
161calcium ion-dependent exocytosis (GO:0017156)2.23163793
162cilium assembly (GO:0042384)2.22926097
163positive regulation of cellular amide metabolic process (GO:0034250)2.22782288
164indolalkylamine metabolic process (GO:0006586)2.22710474
165cellular potassium ion transport (GO:0071804)2.22539385
166potassium ion transmembrane transport (GO:0071805)2.22539385
167positive regulation of osteoclast differentiation (GO:0045672)2.22496199
168synapse assembly (GO:0007416)2.22132662
169exogenous drug catabolic process (GO:0042738)2.21793168
170positive regulation of exocytosis (GO:0045921)2.21348512
171regulation of vesicle fusion (GO:0031338)2.20651236
172neuron recognition (GO:0008038)2.20622750
173striatum development (GO:0021756)2.20335993
174gamma-aminobutyric acid transport (GO:0015812)2.20024490
175Golgi to plasma membrane protein transport (GO:0043001)2.19854884
176negative regulation of dendrite development (GO:2000171)2.19787520
177neurotransmitter transport (GO:0006836)2.19762859
178potassium ion import (GO:0010107)2.19539841
179phosphatidylethanolamine biosynthetic process (GO:0006646)2.19278697
180epithelial cilium movement (GO:0003351)2.19152993
181adenosine metabolic process (GO:0046085)2.19025030
182nucleoside diphosphate catabolic process (GO:0009134)2.19001996
183protein localization to Golgi apparatus (GO:0034067)2.17500428
184cellular response to glucagon stimulus (GO:0071377)2.17488253
185regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.17448142
186regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.16761069
187aromatic amino acid family catabolic process (GO:0009074)2.16415220
188COPI coating of Golgi vesicle (GO:0048205)2.15783516
189zinc ion homeostasis (GO:0055069)2.15715122
190parental behavior (GO:0060746)2.14453830
191piRNA metabolic process (GO:0034587)2.13997788
192polyol catabolic process (GO:0046174)2.13355174
193drug transport (GO:0015893)2.13235807
194aggressive behavior (GO:0002118)2.13205153
195regulation of type B pancreatic cell apoptotic process (GO:2000674)2.12864814

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.15926752
2EZH2_22144423_ChIP-Seq_EOC_Human3.62034666
3SALL1_21062744_ChIP-ChIP_HESCs_Human2.65299405
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.32970858
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.26426327
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.23104871
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23090587
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.15345885
9ZNF274_21170338_ChIP-Seq_K562_Hela2.15072158
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.11595593
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.03522807
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.02426626
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.02299911
14* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.01159146
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00064721
16EED_16625203_ChIP-ChIP_MESCs_Mouse1.97131715
17DROSHA_22980978_ChIP-Seq_HELA_Human1.96821030
18IGF1R_20145208_ChIP-Seq_DFB_Human1.95086393
19PIAS1_25552417_ChIP-Seq_VCAP_Human1.94245031
20TAF15_26573619_Chip-Seq_HEK293_Human1.92110784
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.89436837
22SMAD4_21799915_ChIP-Seq_A2780_Human1.89035669
23* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.87857761
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.87333951
25P300_19829295_ChIP-Seq_ESCs_Human1.84800835
26MTF2_20144788_ChIP-Seq_MESCs_Mouse1.84340143
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81208679
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.77815710
29REST_21632747_ChIP-Seq_MESCs_Mouse1.75220229
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.74378835
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.74378835
32EWS_26573619_Chip-Seq_HEK293_Human1.73844515
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73077589
34BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.72635024
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71328399
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68806984
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.65651723
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.65316041
39VDR_22108803_ChIP-Seq_LS180_Human1.65048554
40NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.63661027
41NRF2_20460467_ChIP-Seq_MEFs_Mouse1.63661027
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.61430459
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58434764
44CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.58264705
45CDX2_22108803_ChIP-Seq_LS180_Human1.51462628
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50249215
47CBP_20019798_ChIP-Seq_JUKART_Human1.50249215
48STAT3_23295773_ChIP-Seq_U87_Human1.50174130
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.47121317
50CRX_20693478_ChIP-Seq_RETINA_Mouse1.45763125
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45308055
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.44900396
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.44780420
54CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.44626188
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.43369210
56FOXM1_26456572_ChIP-Seq_MCF-7_Human1.43318936
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.43251973
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.42991507
59TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.42184538
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42119780
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.41307410
62EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.41085625
63IRF8_22096565_ChIP-ChIP_GC-B_Human1.40606662
64CJUN_26792858_Chip-Seq_BT549_Human1.39456713
65EGR1_23403033_ChIP-Seq_LIVER_Mouse1.38891036
66Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.38845173
67P53_22387025_ChIP-Seq_ESCs_Mouse1.38138181
68EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.37264318
69FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37236369
70AR_25329375_ChIP-Seq_VCAP_Human1.35371895
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.35304039
72OCT4_21477851_ChIP-Seq_ESCs_Mouse1.34624871
73* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34366687
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34301151
75AR_21572438_ChIP-Seq_LNCaP_Human1.33994492
76* TCF4_23295773_ChIP-Seq_U87_Human1.32515491
77TP53_18474530_ChIP-ChIP_U2OS_Human1.30645871
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30587734
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29926478
80E2F1_18555785_Chip-Seq_ESCs_Mouse1.28800484
81SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.27118509
82SUZ12_18555785_Chip-Seq_ESCs_Mouse1.26039042
83RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.25622189
84* RUNX2_22187159_ChIP-Seq_PCA_Human1.25063925
85FUS_26573619_Chip-Seq_HEK293_Human1.25014204
86CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.24605375
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23922232
88* SOX2_21211035_ChIP-Seq_LN229_Gbm1.23563288
89REST_18959480_ChIP-ChIP_MESCs_Mouse1.23050492
90NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22532504
91SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22319443
92CMYC_18555785_Chip-Seq_ESCs_Mouse1.22030364
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21444656
94BCAT_22108803_ChIP-Seq_LS180_Human1.20319177
95TCF4_22108803_ChIP-Seq_LS180_Human1.19948605
96STAT3_18555785_Chip-Seq_ESCs_Mouse1.19619534
97PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19037812
98TP53_16413492_ChIP-PET_HCT116_Human1.18956153
99FLI1_21867929_ChIP-Seq_TH2_Mouse1.18689414
100EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.18409104
101ARNT_22903824_ChIP-Seq_MCF-7_Human1.18343813
102CBX2_27304074_Chip-Seq_ESCs_Mouse1.18245903
103SOX2_18555785_Chip-Seq_ESCs_Mouse1.16695240
104RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16594224
105EZH2_27294783_Chip-Seq_NPCs_Mouse1.15941953
106TP63_23658742_ChIP-Seq_EP156T_Human1.15902126
107ER_23166858_ChIP-Seq_MCF-7_Human1.15298440
108GATA2_21666600_ChIP-Seq_HMVEC_Human1.15218678
109UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14704284
110BRD4_25478319_ChIP-Seq_HGPS_Human1.14594427
111P300_18555785_Chip-Seq_ESCs_Mouse1.14273506
112NFE2_27457419_Chip-Seq_LIVER_Mouse1.14140685
113RARB_27405468_Chip-Seq_BRAIN_Mouse1.14024287
114FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13177209
115KDM2B_26808549_Chip-Seq_REH_Human1.12363076
116RUNX1_27457419_Chip-Seq_LIVER_Mouse1.12021880
117KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11779234
118NMYC_18555785_Chip-Seq_ESCs_Mouse1.11378963
119PU1_27457419_Chip-Seq_LIVER_Mouse1.10686408
120IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09923557
121PRDM14_20953172_ChIP-Seq_ESCs_Human1.09061998
122AHR_22903824_ChIP-Seq_MCF-7_Human1.08981623
123VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08601697
124TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05354438
125PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05215242
126TCF4_18268006_ChIP-ChIP_LS174T_Human1.04682325
127YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04252924
128ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03518360
129SMAD1_18555785_Chip-Seq_ESCs_Mouse1.03157679
130TAL1_26923725_Chip-Seq_HPCs_Mouse1.02542126
131SOX2_19829295_ChIP-Seq_ESCs_Human1.02125925
132NANOG_19829295_ChIP-Seq_ESCs_Human1.02125925
133CTCF_18555785_Chip-Seq_ESCs_Mouse1.01557106
134AR_19668381_ChIP-Seq_PC3_Human1.01462483
135TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00824649
136OCT4_18555785_Chip-Seq_ESCs_Mouse1.00506725
137PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00100942

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006054_spinal_hemorrhage4.05941938
2MP0005646_abnormal_pituitary_gland3.27394682
3MP0004859_abnormal_synaptic_plasticity3.07250164
4MP0002139_abnormal_hepatobiliary_system3.05925691
5MP0003880_abnormal_central_pattern2.94160208
6MP0009780_abnormal_chondrocyte_physiolo2.93616837
7MP0001984_abnormal_olfaction2.91727940
8MP0003252_abnormal_bile_duct2.85016055
9MP0005645_abnormal_hypothalamus_physiol2.83114798
10MP0003183_abnormal_peptide_metabolism2.70221709
11MP0003635_abnormal_synaptic_transmissio2.66976683
12MP0005085_abnormal_gallbladder_physiolo2.62469888
13MP0002138_abnormal_hepatobiliary_system2.54661915
14MP0010234_abnormal_vibrissa_follicle2.53344368
15MP0008875_abnormal_xenobiotic_pharmacok2.51515291
16MP0005360_urolithiasis2.49310856
17MP0009745_abnormal_behavioral_response2.44501103
18MP0000427_abnormal_hair_cycle2.38454774
19MP0002909_abnormal_adrenal_gland2.34220628
20MP0001486_abnormal_startle_reflex2.29916584
21MP0002064_seizures2.22121828
22MP0010386_abnormal_urinary_bladder2.20995625
23MP0002572_abnormal_emotion/affect_behav2.20969081
24MP0010678_abnormal_skin_adnexa2.17907575
25MP0004270_analgesia2.17360537
26MP0001188_hyperpigmentation2.17006092
27MP0002063_abnormal_learning/memory/cond2.10053324
28MP0009046_muscle_twitch2.06314050
29MP0002272_abnormal_nervous_system2.06127164
30MP0000013_abnormal_adipose_tissue1.98943649
31MP0008057_abnormal_DNA_replication1.96963005
32MP0003950_abnormal_plasma_membrane1.93968843
33MP0005365_abnormal_bile_salt1.90535093
34MP0005379_endocrine/exocrine_gland_phen1.90514215
35MP0002877_abnormal_melanocyte_morpholog1.87090988
36MP0001502_abnormal_circadian_rhythm1.86983933
37MP0000383_abnormal_hair_follicle1.85977564
38MP0001968_abnormal_touch/_nociception1.80464902
39MP0002734_abnormal_mechanical_nocicepti1.77971802
40MP0002735_abnormal_chemical_nociception1.77415598
41MP0002638_abnormal_pupillary_reflex1.77020925
42MP0004043_abnormal_pH_regulation1.73103295
43MP0002557_abnormal_social/conspecific_i1.72402053
44MP0001501_abnormal_sleep_pattern1.72236343
45MP0001666_abnormal_nutrient_absorption1.70034335
46MP0010329_abnormal_lipoprotein_level1.68874213
47MP0002067_abnormal_sensory_capabilities1.68109996
48MP0002736_abnormal_nociception_after1.66130983
49MP0005551_abnormal_eye_electrophysiolog1.65518126
50MP0003172_abnormal_lysosome_physiology1.63706121
51MP0002876_abnormal_thyroid_physiology1.61940106
52MP0002693_abnormal_pancreas_physiology1.56717879
53MP0005187_abnormal_penis_morphology1.55009426
54MP0003300_gastrointestinal_ulcer1.54020364
55MP0000647_abnormal_sebaceous_gland1.50298086
56MP0002168_other_aberrant_phenotype1.49649028
57MP0005408_hypopigmentation1.42207935
58MP0001764_abnormal_homeostasis1.39359040
59MP0003879_abnormal_hair_cell1.38483619
60MP0002928_abnormal_bile_duct1.37757389
61MP0005332_abnormal_amino_acid1.36866524
62MP0003195_calcinosis1.36028138
63MP0001944_abnormal_pancreas_morphology1.34550029
64MP0001485_abnormal_pinna_reflex1.33238989
65MP0005423_abnormal_somatic_nervous1.32689272
66MP0004742_abnormal_vestibular_system1.30973902
67MP0002009_preneoplasia1.29233436
68MP0002822_catalepsy1.28990978
69MP0005670_abnormal_white_adipose1.27731383
70MP0003633_abnormal_nervous_system1.26885946
71MP0001970_abnormal_pain_threshold1.26621611
72MP0004885_abnormal_endolymph1.26284085
73MP0005395_other_phenotype1.25567053
74MP0005535_abnormal_body_temperature1.25235806
75MP0000631_abnormal_neuroendocrine_gland1.25130081
76MP0000465_gastrointestinal_hemorrhage1.24585625
77MP0002184_abnormal_innervation1.24497497
78MP0008569_lethality_at_weaning1.23665911
79MP0006276_abnormal_autonomic_nervous1.21687872
80MP0003329_amyloid_beta_deposits1.20953091
81MP0002733_abnormal_thermal_nociception1.19684090
82MP0001440_abnormal_grooming_behavior1.19628572
83MP0003191_abnormal_cellular_cholesterol1.18395639
84MP0003690_abnormal_glial_cell1.17851519
85MP0000569_abnormal_digit_pigmentation1.17039441
86MP0001756_abnormal_urination1.16643280
87MP0010368_abnormal_lymphatic_system1.14135651
88MP0003943_abnormal_hepatobiliary_system1.13666836
89MP0002229_neurodegeneration1.13420043
90MP0004019_abnormal_vitamin_homeostasis1.13379669
91MP0005174_abnormal_tail_pigmentation1.12555913
92MP0001963_abnormal_hearing_physiology1.12420497
93MP0002837_dystrophic_cardiac_calcinosis1.12373970
94MP0001986_abnormal_taste_sensitivity1.11758848
95MP0009785_altered_susceptibility_to1.09521989
96MP0004134_abnormal_chest_morphology1.07595837
97MP0006082_CNS_inflammation1.07506421
98MP0004142_abnormal_muscle_tone1.06673807
99MP0002078_abnormal_glucose_homeostasis1.05525870
100MP0000681_abnormal_thyroid_gland1.03250269
101MP0006072_abnormal_retinal_apoptosis1.01926692
102MP0001664_abnormal_digestion1.00563707
103MP0005084_abnormal_gallbladder_morpholo1.00105859
104MP0003787_abnormal_imprinting0.99682275
105MP0004924_abnormal_behavior0.99550358
106MP0005386_behavior/neurological_phenoty0.99550358
107MP0001765_abnormal_ion_homeostasis0.98653948
108MP0002882_abnormal_neuron_morphology0.98428306
109MP0003953_abnormal_hormone_level0.96271516
110MP0003045_fibrosis0.95862632
111MP0000778_abnormal_nervous_system0.95419811
112MP0003656_abnormal_erythrocyte_physiolo0.95195009
113MP0003631_nervous_system_phenotype0.95138111
114MP0005075_abnormal_melanosome_morpholog0.94726370
115MP0005410_abnormal_fertilization0.94365586
116MP0003122_maternal_imprinting0.92967158
117MP0002166_altered_tumor_susceptibility0.90402243
118MP0000538_abnormal_urinary_bladder0.90106445
119MP0000371_diluted_coat_color0.89013343
120MP0002066_abnormal_motor_capabilities/c0.88666445
121MP0002118_abnormal_lipid_homeostasis0.88594489
122MP0005253_abnormal_eye_physiology0.88523646
123MP0006292_abnormal_olfactory_placode0.87797755
124MP0003718_maternal_effect0.87287776
125MP0000955_abnormal_spinal_cord0.85698963
126MP0002069_abnormal_eating/drinking_beha0.85632385
127MP0000639_abnormal_adrenal_gland0.84237266
128MP0009697_abnormal_copulation0.84142772
129MP0002090_abnormal_vision0.83411008
130MP0000026_abnormal_inner_ear0.82846914
131MP0003868_abnormal_feces_composition0.82772999
132MP0005389_reproductive_system_phenotype0.82253887
133MP0002160_abnormal_reproductive_system0.82225584
134MP0000609_abnormal_liver_physiology0.82181174
135MP0004883_abnormal_blood_vessel0.81316586
136MP0003634_abnormal_glial_cell0.80337927
137MP0001177_atelectasis0.79790909
138MP0000566_synostosis0.79575697
139MP0005220_abnormal_exocrine_pancreas0.79484598
140MP0005310_abnormal_salivary_gland0.78827913
141MP0005171_absent_coat_pigmentation0.77337530
142MP0004484_altered_response_of0.75842510
143MP0000003_abnormal_adipose_tissue0.75565915
144MP0010352_gastrointestinal_tract_polyps0.75233659
145MP0001324_abnormal_eye_pigmentation0.75149691
146MP0004811_abnormal_neuron_physiology0.74835862
147MP0008004_abnormal_stomach_pH0.74801854
148MP0004264_abnormal_extraembryonic_tissu0.74466465
149MP0005319_abnormal_enzyme/_coenzyme0.74042079
150MP0005636_abnormal_mineral_homeostasis0.73937161
151MP0005167_abnormal_blood-brain_barrier0.73831396
152MP0001299_abnormal_eye_distance/0.73586928
153MP0002234_abnormal_pharynx_morphology0.73582982
154MP0000920_abnormal_myelination0.72615537
155MP0001661_extended_life_span0.72517255
156MP0000230_abnormal_systemic_arterial0.72313399
157MP0000015_abnormal_ear_pigmentation0.71695496
158MP0005448_abnormal_energy_balance0.71123315
159MP0002933_joint_inflammation0.70392120
160MP0009643_abnormal_urine_homeostasis0.70109275
161MP0005058_abnormal_lysosome_morphology0.69785510
162MP0010155_abnormal_intestine_physiology0.69727859
163MP0005164_abnormal_response_to0.68818504
164MP0004215_abnormal_myocardial_fiber0.68190169
165MP0003724_increased_susceptibility_to0.66502093
166MP0001191_abnormal_skin_condition0.66483205

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.17638424
2Febrile seizures (HP:0002373)4.24873430
3Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.99872690
4Epileptic encephalopathy (HP:0200134)3.84272447
5Chronic hepatic failure (HP:0100626)3.65087082
6Hypothermia (HP:0002045)3.60275720
7Hypoglycemic seizures (HP:0002173)3.50626784
8Hyperventilation (HP:0002883)3.43240216
9Hyperinsulinemic hypoglycemia (HP:0000825)3.34100693
10Abnormality of the renal cortex (HP:0011035)3.31730797
11Retinal dysplasia (HP:0007973)3.30862846
12Focal seizures (HP:0007359)3.28409410
13Symptomatic seizures (HP:0011145)3.24979957
14Atonic seizures (HP:0010819)3.15825070
15Generalized hypopigmentation of hair (HP:0011358)3.09874958
16Generalized tonic-clonic seizures (HP:0002069)3.04285435
17Decreased circulating renin level (HP:0003351)3.00591778
18Retinal atrophy (HP:0001105)2.98174269
19Abnormality of calcium-phosphate metabolism (HP:0100530)2.91274025
20Ketoacidosis (HP:0001993)2.83299123
21Papillary thyroid carcinoma (HP:0002895)2.79489913
22Aplasia/Hypoplasia of the tibia (HP:0005772)2.71568343
23Thyroid carcinoma (HP:0002890)2.62826511
24Metaphyseal dysplasia (HP:0100255)2.61360234
25Blue irides (HP:0000635)2.61022337
26Proximal tubulopathy (HP:0000114)2.59757713
27Pancreatic cysts (HP:0001737)2.58434046
28Periodontitis (HP:0000704)2.57587942
29Visual hallucinations (HP:0002367)2.54855143
30Pancreatic fibrosis (HP:0100732)2.50146065
31Tetraparesis (HP:0002273)2.47933645
32Fair hair (HP:0002286)2.47723123
33Type II lissencephaly (HP:0007260)2.45891006
34Dynein arm defect of respiratory motile cilia (HP:0012255)2.43141525
35Absent/shortened dynein arms (HP:0200106)2.43141525
36Epidermoid cyst (HP:0200040)2.39613560
37Glucose intolerance (HP:0000833)2.39343516
38Abnormal ciliary motility (HP:0012262)2.39100340
39Absence seizures (HP:0002121)2.37885298
40Epileptiform EEG discharges (HP:0011182)2.37460093
41Medial flaring of the eyebrow (HP:0010747)2.37072972
42Lower limb hyperreflexia (HP:0002395)2.36779831
43Tubulointerstitial nephritis (HP:0001970)2.34671772
44Abnormality of macular pigmentation (HP:0008002)2.32817277
45Dysostosis multiplex (HP:0000943)2.32448115
46Short tibia (HP:0005736)2.31316940
47Bile duct proliferation (HP:0001408)2.29691730
48Abnormal biliary tract physiology (HP:0012439)2.29691730
49Gait imbalance (HP:0002141)2.29369101
50Hypoglycemic coma (HP:0001325)2.28368543
51Abnormality of polysaccharide metabolism (HP:0011012)2.28106371
52Abnormality of glycosaminoglycan metabolism (HP:0004371)2.28106371
53Abnormality of mucopolysaccharide metabolism (HP:0011020)2.28106371
54Abnormal biliary tract morphology (HP:0012440)2.27259920
55EEG with generalized epileptiform discharges (HP:0011198)2.25647791
56Cortical visual impairment (HP:0100704)2.25113406
57Diplopia (HP:0000651)2.24526011
58Abnormality of binocular vision (HP:0011514)2.24526011
59Dialeptic seizures (HP:0011146)2.23800162
60Thyroiditis (HP:0100646)2.23362406
61Amyotrophic lateral sclerosis (HP:0007354)2.23144472
62Protruding tongue (HP:0010808)2.22944174
63Nephrogenic diabetes insipidus (HP:0009806)2.22917851
64Congenital primary aphakia (HP:0007707)2.21662971
65Insulin-resistant diabetes mellitus (HP:0000831)2.19170415
66Excessive salivation (HP:0003781)2.17441418
67Drooling (HP:0002307)2.17441418
68Urinary glycosaminoglycan excretion (HP:0003541)2.16741995
69Mucopolysacchariduria (HP:0008155)2.16741995
70True hermaphroditism (HP:0010459)2.16302046
71Curly hair (HP:0002212)2.15666212
72Hypophosphatemic rickets (HP:0004912)2.14677678
73Hemiparesis (HP:0001269)2.14109970
74Menstrual irregularities (HP:0000858)2.14065471
75Hyperphosphatemia (HP:0002905)2.13155175
76Abnormality of renin-angiotensin system (HP:0000847)2.12852052
77Hypsarrhythmia (HP:0002521)2.12694738
78Molar tooth sign on MRI (HP:0002419)2.12059218
79Abnormality of midbrain morphology (HP:0002418)2.12059218
80Hematochezia (HP:0002573)2.10738020
81Agitation (HP:0000713)2.10143675
82Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.09845429
83Abnormality of alanine metabolism (HP:0010916)2.09845429
84Hyperalaninemia (HP:0003348)2.09845429
85Nephronophthisis (HP:0000090)2.09426446
86Conjugated hyperbilirubinemia (HP:0002908)2.09248252
87Gaze-evoked nystagmus (HP:0000640)2.07768402
88Absent rod-and cone-mediated responses on ERG (HP:0007688)2.06970107
89Action tremor (HP:0002345)2.05970537
90Central scotoma (HP:0000603)2.05594927
91Abnormality of the renal medulla (HP:0100957)2.05171281
92Abnormal respiratory motile cilium physiology (HP:0012261)2.04391719
93Hypobetalipoproteinemia (HP:0003563)2.03298921
94Onycholysis (HP:0001806)2.03178039
95Aplasia/Hypoplasia of the tongue (HP:0010295)2.02432139
96Anxiety (HP:0000739)2.02382187
97Inability to walk (HP:0002540)2.00836107
98Congenital sensorineural hearing impairment (HP:0008527)2.00549843
99Renal cortical cysts (HP:0000803)1.98692987
100Broad-based gait (HP:0002136)1.94625282
101Status epilepticus (HP:0002133)1.94496024
102Postaxial foot polydactyly (HP:0001830)1.93914121
103Chronic diarrhea (HP:0002028)1.92685516
104Neurofibrillary tangles (HP:0002185)1.92307501
105Median cleft lip (HP:0000161)1.91491481
106Progressive cerebellar ataxia (HP:0002073)1.91364397
107Increased circulating renin level (HP:0000848)1.91308398
108Mitral stenosis (HP:0001718)1.90676646
109Absent speech (HP:0001344)1.89575273
110Hyperkalemia (HP:0002153)1.88829064
111Abnormal glucose tolerance (HP:0001952)1.88352032
112Osteomalacia (HP:0002749)1.87938051
113Fat malabsorption (HP:0002630)1.87625181
114Genital tract atresia (HP:0001827)1.87027484
115Syncope (HP:0001279)1.86129540
116Constricted visual fields (HP:0001133)1.86129522
117Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.85952982
118Abnormal rod and cone electroretinograms (HP:0008323)1.85784690
119Depression (HP:0000716)1.84758440
120Abnormality of glycolipid metabolism (HP:0010969)1.83683124
121Abnormality of liposaccharide metabolism (HP:0010968)1.83683124
122Abnormality of glycosphingolipid metabolism (HP:0004343)1.83683124
123Generalized aminoaciduria (HP:0002909)1.83674381
124Neuroendocrine neoplasm (HP:0100634)1.83187835
125Increased CSF protein (HP:0002922)1.83122208
126Degeneration of the lateral corticospinal tracts (HP:0002314)1.82940948
127Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.82940948
128Progressive inability to walk (HP:0002505)1.81803948
129Abnormality of the common coagulation pathway (HP:0010990)1.79888645
130Loss of speech (HP:0002371)1.79653893
131Truncal ataxia (HP:0002078)1.79512571
132Upper limb muscle weakness (HP:0003484)1.77839118
133Poor eye contact (HP:0000817)1.77688256
134Steatorrhea (HP:0002570)1.77307902
135Papilledema (HP:0001085)1.77273324
136Abnormal respiratory epithelium morphology (HP:0012253)1.77147425
137Abnormal respiratory motile cilium morphology (HP:0005938)1.77147425
138Pheochromocytoma (HP:0002666)1.76725292
139Dyskinesia (HP:0100660)1.76265027
140Cheilitis (HP:0100825)1.75644821
141Absent frontal sinuses (HP:0002688)1.74304374
142Hyperactive renin-angiotensin system (HP:0000841)1.73763261
143Epiphyseal dysplasia (HP:0002656)1.73119511
144Pancreatic islet-cell hyperplasia (HP:0004510)1.72774429
145Tubulointerstitial fibrosis (HP:0005576)1.71976482
146Supranuclear gaze palsy (HP:0000605)1.71754981
147Congenital stationary night blindness (HP:0007642)1.71601690
148Clumsiness (HP:0002312)1.71387425
149Albinism (HP:0001022)1.70099994
150Tubulointerstitial abnormality (HP:0001969)1.69661357
151Hyperaldosteronism (HP:0000859)1.68579885
152Bradycardia (HP:0001662)1.68289988
153Vacuolated lymphocytes (HP:0001922)1.67723828
154Hydroxyprolinuria (HP:0003080)1.67525606
155Abnormality of proline metabolism (HP:0010907)1.67525606
156Postaxial hand polydactyly (HP:0001162)1.66478282
157Stomach cancer (HP:0012126)1.66255625
158Coarse hair (HP:0002208)1.65504546
159Intrahepatic cholestasis (HP:0001406)1.65299024
160Congenital hepatic fibrosis (HP:0002612)1.64173365
161Biliary tract neoplasm (HP:0100574)1.64164425
162Attenuation of retinal blood vessels (HP:0007843)1.63884234
163Prolonged partial thromboplastin time (HP:0003645)1.63829482
164Azoospermia (HP:0000027)1.63191700
165Rhinitis (HP:0012384)1.62207277
166Ketosis (HP:0001946)1.62099709
167Cutaneous melanoma (HP:0012056)1.61813009
168Widely spaced teeth (HP:0000687)1.59056103
169Abnormality of glutamine family amino acid metabolism (HP:0010902)1.57308119
170Genetic anticipation (HP:0003743)1.55567716

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.45173445
2ACVR1B3.44955296
3CASK3.43867406
4NTRK33.29399900
5INSRR3.18131098
6TNIK3.14150348
7TRIM282.88023157
8TIE12.77103835
9MAP2K72.60383186
10EPHA42.53682906
11SIK32.44176041
12MST42.18551049
13STK392.11335941
14MAP3K42.03233565
15MAP3K121.98504320
16NTRK21.81397032
17TRPM71.77383092
18SGK21.75980877
19NEK61.69987971
20MAP2K41.60301279
21NTRK11.56343744
22CAMKK21.55484158
23FRK1.54124097
24SGK4941.47723997
25SGK2231.47723997
26SGK31.42880102
27FLT31.39908776
28NEK91.37937164
29MAPK151.34286975
30GRK11.29122480
31IRAK31.27646725
32MAP3K21.26824544
33TAOK31.24699871
34CAMK1G1.23394695
35PRKD31.21821931
36LATS11.21551023
37MINK11.21201464
38STK38L1.18944151
39ADRBK21.16866169
40WNK31.12403816
41TEC1.11061912
42PRKCE1.09228875
43KSR11.07416473
44CSNK1A1L1.05776192
45BMPR21.05402466
46PNCK1.05292379
47SIK11.04339283
48STK31.01893651
49TNK21.00564005
50PIK3CA0.99446420
51PRKCH0.99374582
52TXK0.95062066
53MAPK130.93684482
54ERBB30.93468782
55MAPKAPK30.90896368
56MUSK0.88608441
57MAP3K130.88370534
58CSNK1G30.87525501
59BMPR1B0.85772251
60PLK20.85624090
61PRKCG0.83872252
62LMTK20.83863553
63CAMK1D0.83783602
64PIK3CG0.82747461
65CDK50.82241252
66PTK2B0.82014340
67CAMK2A0.80811244
68MARK10.79818108
69PAK30.79095526
70RIPK40.78620704
71HIPK20.77259657
72CSNK1G10.76357279
73BCR0.76306124
74OXSR10.76010335
75BRSK20.75735178
76AKT30.74968806
77PINK10.74305007
78JAK10.73906466
79WNK40.72760672
80GRK70.71568564
81CAMK2D0.71017510
82DAPK20.70378326
83SGK10.68442587
84DYRK1A0.68138877
85MAP3K90.67964108
86RPS6KA40.67719125
87FER0.66507612
88CAMK2B0.65301609
89CAMK10.64931204
90TGFBR10.64337832
91WNK10.63935601
92MET0.62667249
93NEK10.59880434
94MAP3K60.59842752
95CDK190.59838503
96NUAK10.56849864
97CSF1R0.56535437
98PKN20.56513247
99DAPK10.56439149
100SCYL20.54209246
101EIF2AK30.52716869
102ARAF0.52680856
103PRKCQ0.52166722
104STK380.51645664
105IRAK10.51515870
106KIT0.51045737
107YES10.50318425
108IGF1R0.50099216
109IKBKE0.50058962
110EPHA30.49956308
111CSNK1G20.49426641
112IRAK20.49330647
113MAP3K140.48482658
114MAP2K10.48457655
115FES0.48021978
116CAMK2G0.47691738
117TGFBR20.47411194
118ABL10.46850372
119PHKG10.46842008
120PHKG20.46842008
121KSR20.46548968
122CAMKK10.45670220
123FGFR30.44829954
124RAF10.44545155
125MKNK20.44303535
126PRPF4B0.44238604
127TYK20.43808592
128EGFR0.42355368
129ADRBK10.42303923
130CDC42BPA0.41160500
131RET0.40936566
132PRKACA0.38875538
133MAP3K10.38573238
134PRKG10.38347747
135IRAK40.38190444
136STK240.37883893
137MAP2K60.37083699
138CDK60.36565096
139FGFR10.33543210
140MST1R0.33475709
141PRKAA20.33302507
142JAK20.33163979
143RPS6KB10.31442993
144BRD40.31270996
145PDK10.30442926
146JAK30.30251630
147ERBB20.29329092
148CSNK1D0.28780111

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002323.68287884
2Olfactory transduction_Homo sapiens_hsa047402.77795542
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.75787008
4Insulin secretion_Homo sapiens_hsa049112.69960853
5Nicotine addiction_Homo sapiens_hsa050332.65576971
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.52691123
7Morphine addiction_Homo sapiens_hsa050322.36733122
8GABAergic synapse_Homo sapiens_hsa047272.27105339
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.24808554
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.19396886
11Circadian entrainment_Homo sapiens_hsa047132.12723248
12Synaptic vesicle cycle_Homo sapiens_hsa047211.94791491
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.89620280
14Taste transduction_Homo sapiens_hsa047421.84679417
15Amphetamine addiction_Homo sapiens_hsa050311.84540995
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.82229084
17Glutamatergic synapse_Homo sapiens_hsa047241.81562419
18Salivary secretion_Homo sapiens_hsa049701.79411295
19Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.78244109
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.73270615
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.63682303
22Vibrio cholerae infection_Homo sapiens_hsa051101.60671232
23Complement and coagulation cascades_Homo sapiens_hsa046101.59549640
24Gastric acid secretion_Homo sapiens_hsa049711.58384718
25Dopaminergic synapse_Homo sapiens_hsa047281.51216605
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.49585106
27Phototransduction_Homo sapiens_hsa047441.47317322
28Serotonergic synapse_Homo sapiens_hsa047261.45830455
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.45242984
30Cocaine addiction_Homo sapiens_hsa050301.42979068
31Renin secretion_Homo sapiens_hsa049241.42001373
32Chemical carcinogenesis_Homo sapiens_hsa052041.40091429
33Peroxisome_Homo sapiens_hsa041461.39696969
34Long-term potentiation_Homo sapiens_hsa047201.38734068
35Sulfur metabolism_Homo sapiens_hsa009201.33767110
36Calcium signaling pathway_Homo sapiens_hsa040201.32985126
37Retinol metabolism_Homo sapiens_hsa008301.32611146
38Collecting duct acid secretion_Homo sapiens_hsa049661.31659993
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30547917
40Cholinergic synapse_Homo sapiens_hsa047251.25495557
41cAMP signaling pathway_Homo sapiens_hsa040241.24881335
42Steroid biosynthesis_Homo sapiens_hsa001001.23062172
43Nitrogen metabolism_Homo sapiens_hsa009101.22769404
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.22361980
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.22299122
46Protein export_Homo sapiens_hsa030601.20271496
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.19400113
48Type II diabetes mellitus_Homo sapiens_hsa049301.16306464
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.11787220
50Pancreatic secretion_Homo sapiens_hsa049721.10488199
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09293055
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08665275
53Glycosaminoglycan degradation_Homo sapiens_hsa005311.08520684
54Pentose and glucuronate interconversions_Homo sapiens_hsa000401.08337800
55Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.07258656
56Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.04396299
57Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04117946
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03026318
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.02513180
60Thyroid hormone synthesis_Homo sapiens_hsa049181.02305505
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.00921678
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00852254
63Ovarian steroidogenesis_Homo sapiens_hsa049130.97457370
64Lysosome_Homo sapiens_hsa041420.96906504
65Ether lipid metabolism_Homo sapiens_hsa005650.88609233
66Selenocompound metabolism_Homo sapiens_hsa004500.88420947
67Bile secretion_Homo sapiens_hsa049760.87509789
68PPAR signaling pathway_Homo sapiens_hsa033200.87102669
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87086557
70cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86861714
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84973997
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.84949556
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.83453791
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82743292
75Starch and sucrose metabolism_Homo sapiens_hsa005000.81936897
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81448484
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81289193
78Type I diabetes mellitus_Homo sapiens_hsa049400.81180575
79Non-homologous end-joining_Homo sapiens_hsa034500.80416252
80ABC transporters_Homo sapiens_hsa020100.80091505
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.79827776
82Linoleic acid metabolism_Homo sapiens_hsa005910.79709585
83Circadian rhythm_Homo sapiens_hsa047100.79504731
84Glucagon signaling pathway_Homo sapiens_hsa049220.78477046
85Oxytocin signaling pathway_Homo sapiens_hsa049210.78383729
86Long-term depression_Homo sapiens_hsa047300.77000834
87Regulation of autophagy_Homo sapiens_hsa041400.75690477
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75668923
89Inositol phosphate metabolism_Homo sapiens_hsa005620.73337081
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72623431
91Rheumatoid arthritis_Homo sapiens_hsa053230.70899560
92Fatty acid metabolism_Homo sapiens_hsa012120.69913104
93N-Glycan biosynthesis_Homo sapiens_hsa005100.68935845
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67069991
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66744521
96Sphingolipid metabolism_Homo sapiens_hsa006000.66485671
97Melanogenesis_Homo sapiens_hsa049160.65807690
98Histidine metabolism_Homo sapiens_hsa003400.64910682
99Basal transcription factors_Homo sapiens_hsa030220.64239732
100GnRH signaling pathway_Homo sapiens_hsa049120.63857420
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63688156
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63500242
103Estrogen signaling pathway_Homo sapiens_hsa049150.62312937
104Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58784004
105Fatty acid elongation_Homo sapiens_hsa000620.58203736
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.56950549
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.56475417
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56435633
109Propanoate metabolism_Homo sapiens_hsa006400.55994277
110Fatty acid biosynthesis_Homo sapiens_hsa000610.54875801
111Other glycan degradation_Homo sapiens_hsa005110.53610263
112NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52734785
113Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52598851
114Mineral absorption_Homo sapiens_hsa049780.51204823
115Fatty acid degradation_Homo sapiens_hsa000710.50853556
116RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.50786195
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50020803
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49734945
119Butanoate metabolism_Homo sapiens_hsa006500.49166703
120Renin-angiotensin system_Homo sapiens_hsa046140.47774748
121beta-Alanine metabolism_Homo sapiens_hsa004100.47006783
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46543934
123Dilated cardiomyopathy_Homo sapiens_hsa054140.46122400
124Gap junction_Homo sapiens_hsa045400.43731952
125Dorso-ventral axis formation_Homo sapiens_hsa043200.42425286
126Glycerolipid metabolism_Homo sapiens_hsa005610.42172582
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41628170
128ErbB signaling pathway_Homo sapiens_hsa040120.41610919
129Fat digestion and absorption_Homo sapiens_hsa049750.40976980
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39733901
131alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39464642
132Choline metabolism in cancer_Homo sapiens_hsa052310.38712372
133Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36905349
134Pertussis_Homo sapiens_hsa051330.36706849
135mTOR signaling pathway_Homo sapiens_hsa041500.36662424
136Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36565358
137Phagosome_Homo sapiens_hsa041450.36111955
138Prolactin signaling pathway_Homo sapiens_hsa049170.35879748
139Ras signaling pathway_Homo sapiens_hsa040140.34426232
140Prion diseases_Homo sapiens_hsa050200.33579303
141Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32314751
142Phospholipase D signaling pathway_Homo sapiens_hsa040720.31963870
143Tryptophan metabolism_Homo sapiens_hsa003800.31162371
144Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31024481
145Axon guidance_Homo sapiens_hsa043600.30244910
146Glycerophospholipid metabolism_Homo sapiens_hsa005640.26661193

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