SNX17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.01489183
2Golgi transport vesicle coating (GO:0048200)5.01489183
3purine deoxyribonucleotide catabolic process (GO:0009155)4.78992389
4nucleoside diphosphate catabolic process (GO:0009134)4.21483449
5pinocytosis (GO:0006907)4.21439770
6negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.19332385
7regulation of early endosome to late endosome transport (GO:2000641)4.12654905
8regulation of mitochondrial translation (GO:0070129)3.89695356
9positive regulation of lamellipodium organization (GO:1902745)3.88967500
10respiratory chain complex IV assembly (GO:0008535)3.88872249
11negative regulation of osteoblast proliferation (GO:0033689)3.78909707
12establishment of viral latency (GO:0019043)3.66825855
13ribosomal small subunit assembly (GO:0000028)3.63641442
14SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.59258000
15positive regulation of actin filament depolymerization (GO:0030836)3.54413167
16cotranslational protein targeting to membrane (GO:0006613)3.53093346
17protein targeting to ER (GO:0045047)3.52453965
18establishment of integrated proviral latency (GO:0075713)3.48114763
19NADPH regeneration (GO:0006740)3.45939393
20deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.44855008
21viral transcription (GO:0019083)3.43986095
22Arp2/3 complex-mediated actin nucleation (GO:0034314)3.43134189
23cytochrome complex assembly (GO:0017004)3.36350412
24establishment of protein localization to endoplasmic reticulum (GO:0072599)3.35129787
25protein localization to endosome (GO:0036010)3.34753375
26protein maturation by protein folding (GO:0022417)3.32776118
27positive regulation of lamellipodium assembly (GO:0010592)3.31395548
28translational termination (GO:0006415)3.29594983
29cullin deneddylation (GO:0010388)3.28923080
30protein localization to endoplasmic reticulum (GO:0070972)3.25229909
31deoxyribonucleotide catabolic process (GO:0009264)3.24152918
32maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.20345137
33glucose catabolic process (GO:0006007)3.19207854
34protein deneddylation (GO:0000338)3.17826599
35sequestering of actin monomers (GO:0042989)3.17779975
36deoxyribose phosphate catabolic process (GO:0046386)3.14695319
37GDP-mannose metabolic process (GO:0019673)3.09290573
38protein retention in ER lumen (GO:0006621)3.08240672
39translational elongation (GO:0006414)3.07779209
40regulation of superoxide anion generation (GO:0032928)3.05284758
41fibril organization (GO:0097435)3.01076995
42UV protection (GO:0009650)2.99944927
43negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.91067082
44negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.87629591
45negative regulation of cell killing (GO:0031342)2.87629591
46pentose metabolic process (GO:0019321)2.85719067
47amyloid precursor protein catabolic process (GO:0042987)2.85378889
48proline biosynthetic process (GO:0006561)2.84890624
49positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.82607595
50NIK/NF-kappaB signaling (GO:0038061)2.82579175
51barbed-end actin filament capping (GO:0051016)2.80161349
52positive regulation by symbiont of host defense response (GO:0052509)2.79559808
53modulation by symbiont of host defense response (GO:0052031)2.79559808
54modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.79559808
55modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.79559808
56positive regulation by organism of defense response of other organism involved in symbiotic interact2.79559808
57modulation by symbiont of host immune response (GO:0052553)2.79559808
58viral life cycle (GO:0019058)2.79197225
59antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.78183358
60antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.78183358
61RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.77790618
62tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.77790618
63L-serine transport (GO:0015825)2.77785434
64extracellular fibril organization (GO:0043206)2.76818192
65protein complex biogenesis (GO:0070271)2.74906414
66antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.73957037
67regulation of chromatin binding (GO:0035561)2.69038445
68response to peptidoglycan (GO:0032494)2.68916800
69antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.66963850
70endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.66566579
71antigen processing and presentation of endogenous antigen (GO:0019883)2.66280030
72antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.66040679
73activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.65192823
74serine transport (GO:0032329)2.64668877
75translational initiation (GO:0006413)2.63815433
76cellular protein complex disassembly (GO:0043624)2.63489842
77positive regulation of gamma-delta T cell activation (GO:0046645)2.59498099
78NADH metabolic process (GO:0006734)2.59214111
79type B pancreatic cell proliferation (GO:0044342)2.57753315
80detection of bacterium (GO:0016045)2.57484604
81protein targeting to membrane (GO:0006612)2.56126342
82ATP hydrolysis coupled proton transport (GO:0015991)2.55466565
83energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.55466565
84negative regulation of erythrocyte differentiation (GO:0045647)2.55151960
85galactose catabolic process (GO:0019388)2.54648143
86negative regulation of gene silencing (GO:0060969)2.53742441
87peptidyl-histidine modification (GO:0018202)2.53737097
88de novo posttranslational protein folding (GO:0051084)2.53438024
89regulation of defense response to virus by virus (GO:0050690)2.52845524
90amino sugar catabolic process (GO:0046348)2.52785195
91negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.51981695
92negative regulation of phagocytosis (GO:0050765)2.51589498
93peptidyl-arginine omega-N-methylation (GO:0035247)2.51293205
94pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.51253484
95neutrophil activation involved in immune response (GO:0002283)2.50147799
96localization within membrane (GO:0051668)2.49928196
97regulation of protein heterodimerization activity (GO:0043497)2.48784381
98detection of other organism (GO:0098543)2.48551496
99formation of translation preinitiation complex (GO:0001731)2.48005647
100immunoglobulin mediated immune response (GO:0016064)2.46521769
101nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.46347264
102positive regulation of nuclease activity (GO:0032075)2.45813558
103activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.45703374
104antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.45323107
105mitochondrial respiratory chain complex assembly (GO:0033108)2.44888903
106positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.43384267
107negative regulation of ligase activity (GO:0051352)2.42148713
108negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.42148713
109viral protein processing (GO:0019082)2.41975121
110de novo protein folding (GO:0006458)2.41200335
111regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.40736317
112base-excision repair, AP site formation (GO:0006285)2.40348165
113virion assembly (GO:0019068)2.39874672
114negative regulation of cell size (GO:0045792)2.39293643
115modulation by virus of host process (GO:0019054)2.39115743
116ribosomal small subunit biogenesis (GO:0042274)2.37294935
117keratan sulfate catabolic process (GO:0042340)2.36848051
118retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.35683690
119protein complex disassembly (GO:0043241)2.35300255
120pentose-phosphate shunt (GO:0006098)2.35229350
121nucleobase-containing small molecule interconversion (GO:0015949)2.34988492
122modulation by symbiont of host cellular process (GO:0044068)2.34868041
123deoxyribose phosphate biosynthetic process (GO:0046385)2.34323105
1242-deoxyribonucleotide biosynthetic process (GO:0009265)2.34323105
125regulation of B cell receptor signaling pathway (GO:0050855)2.34281467
126stress fiber assembly (GO:0043149)2.33436380
127regulation of extracellular matrix disassembly (GO:0010715)2.31909264
128signal peptide processing (GO:0006465)2.31588851
129purine nucleoside diphosphate metabolic process (GO:0009135)2.31324864
130purine ribonucleoside diphosphate metabolic process (GO:0009179)2.31324864
131DNA demethylation (GO:0080111)2.30139097
132glycosphingolipid catabolic process (GO:0046479)2.29576154
133translation (GO:0006412)2.29081411
134regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.28397776
135mature B cell differentiation involved in immune response (GO:0002313)2.28370743
136nucleotide salvage (GO:0043173)2.27948725
137purine nucleotide salvage (GO:0032261)2.27892964
138positive regulation of Cdc42 GTPase activity (GO:0043089)2.27485337
139lipopolysaccharide metabolic process (GO:0008653)2.26816002
140pyrimidine nucleoside salvage (GO:0043097)2.24241372
141pyrimidine-containing compound salvage (GO:0008655)2.24241372
142macromolecular complex disassembly (GO:0032984)2.23961464
143purine deoxyribonucleotide metabolic process (GO:0009151)2.23223913
144actin nucleation (GO:0045010)2.23204552
145regulation of necrotic cell death (GO:0010939)2.23077379
146cellular response to interleukin-4 (GO:0071353)2.23028286
147regulation of nuclease activity (GO:0032069)2.22397140
148tricarboxylic acid metabolic process (GO:0072350)2.21483655
149negative regulation of stress fiber assembly (GO:0051497)2.20739233
150hyaluronan catabolic process (GO:0030214)2.20609506
151pseudouridine synthesis (GO:0001522)2.20592496
152regulation of T cell tolerance induction (GO:0002664)2.20315305
153platelet aggregation (GO:0070527)2.20074880
154regulation of dendritic cell antigen processing and presentation (GO:0002604)2.19750097
155positive regulation of B cell differentiation (GO:0045579)2.19294675
156response to interferon-beta (GO:0035456)2.19158324
157mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.18124386
158chaperone mediated protein folding requiring cofactor (GO:0051085)2.17804622
159morphogenesis of an endothelium (GO:0003159)2.16921323
160endothelial tube morphogenesis (GO:0061154)2.16921323
161metallo-sulfur cluster assembly (GO:0031163)2.16248664
162iron-sulfur cluster assembly (GO:0016226)2.16248664
163regulation of mitochondrial membrane potential (GO:0051881)2.16182034
164positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.15873018
165membrane raft organization (GO:0031579)2.15549227
166regulation of mammary gland epithelial cell proliferation (GO:0033599)2.15365155
167mitochondrial calcium ion transport (GO:0006851)2.14993661
168lipopolysaccharide biosynthetic process (GO:0009103)2.14743094
169membrane protein intracellular domain proteolysis (GO:0031293)2.14394160
170oligosaccharide catabolic process (GO:0009313)2.14179899
171transferrin transport (GO:0033572)2.13270500
172cerebellar Purkinje cell layer development (GO:0021680)2.12346198
173negative regulation of microtubule polymerization (GO:0031115)2.10401953
174negative regulation of norepinephrine secretion (GO:0010700)2.09796436

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.31129673
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.58716112
3ELF1_17652178_ChIP-ChIP_JURKAT_Human2.51090225
4HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.43410492
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.40047067
6VDR_21846776_ChIP-Seq_THP-1_Human2.36356348
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.35445812
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.35372935
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.34838287
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.28823023
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.27215175
12MYC_22102868_ChIP-Seq_BL_Human2.26854322
13* EST1_17652178_ChIP-ChIP_JURKAT_Human2.22940439
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.06392783
15XRN2_22483619_ChIP-Seq_HELA_Human2.04854833
16TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.04053650
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.01664539
18E2F7_22180533_ChIP-Seq_HELA_Human1.97314136
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.93994028
20CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.93555380
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.91495884
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.91222230
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.88562888
24DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.87942794
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.85810302
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.85033264
27MYC_18358816_ChIP-ChIP_MESCs_Mouse1.82753491
28TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82549867
29* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.81865921
30* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.73812244
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.73328257
32BP1_19119308_ChIP-ChIP_Hs578T_Human1.72424283
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.71289062
34MYC_19079543_ChIP-ChIP_MESCs_Mouse1.71181536
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.70314960
36* CIITA_25753668_ChIP-Seq_RAJI_Human1.65585995
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.65257278
38MAF_26560356_Chip-Seq_TH1_Human1.62739804
39GABP_19822575_ChIP-Seq_HepG2_Human1.59797214
40TET1_21451524_ChIP-Seq_MESCs_Mouse1.59748849
41* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.58132694
42CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.57444904
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.57308450
44* TTF2_22483619_ChIP-Seq_HELA_Human1.57300982
45LXR_22292898_ChIP-Seq_THP-1_Human1.54744405
46VDR_23849224_ChIP-Seq_CD4+_Human1.52680565
47* FOXP3_21729870_ChIP-Seq_TREG_Human1.52139627
48SRY_22984422_ChIP-ChIP_TESTIS_Rat1.50830466
49E2F1_18555785_ChIP-Seq_MESCs_Mouse1.50706093
50VDR_24763502_ChIP-Seq_THP-1_Human1.48051859
51MYC_19030024_ChIP-ChIP_MESCs_Mouse1.47654147
52* DCP1A_22483619_ChIP-Seq_HELA_Human1.47071086
53ZNF263_19887448_ChIP-Seq_K562_Human1.47006317
54RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.46681749
55UTX_26944678_Chip-Seq_JUKART_Human1.44112958
56IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.43342421
57* SPI1_23547873_ChIP-Seq_NB4_Human1.42030165
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40998336
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40831647
60TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38764174
61CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.38069438
62FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.37566929
63NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36029475
64HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.34788716
65TFEB_21752829_ChIP-Seq_HELA_Human1.33940706
66PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33188359
67ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.32932786
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.32227629
69IRF8_21731497_ChIP-ChIP_J774_Mouse1.30514676
70KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30254222
71E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.29784687
72KDM2B_26808549_Chip-Seq_DND41_Human1.29628700
73* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.28864142
74NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.28564699
75P68_20966046_ChIP-Seq_HELA_Human1.28523136
76BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26877303
77NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26609288
78ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.26328692
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26046406
80CTCF_27219007_Chip-Seq_ERYTHROID_Human1.24470772
81* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.23561258
82HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22470569
83* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21672478
84CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.21093940
85BCOR_27268052_Chip-Seq_Bcells_Human1.21086211
86PU.1_20513432_ChIP-Seq_Bcells_Mouse1.20923063
87TP63_17297297_ChIP-ChIP_HaCaT_Human1.20217526
88* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.20102372
89CTCF_26484167_Chip-Seq_Bcells_Mouse1.18651411
90SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18137383
91YY1_21170310_ChIP-Seq_MESCs_Mouse1.17771160
92CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16327964
93ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16309012
94CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16170332
95ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16120389
96MAF_26560356_Chip-Seq_TH2_Human1.15682914
97* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15222276
98RUNX1_22412390_ChIP-Seq_EML_Mouse1.14781364
99* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14227046
100* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.13730336
101ELF1_20517297_ChIP-Seq_JURKAT_Human1.13231287
102STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12913198
103KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12628230
104SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12457092
105MYB_26560356_Chip-Seq_TH2_Human1.12031928
106MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12013435
107CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11804708
108SPI1_23127762_ChIP-Seq_K562_Human1.11654192
109MYB_21317192_ChIP-Seq_ERMYB_Mouse1.10346426
110CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08470738
111ELK1_22589737_ChIP-Seq_MCF10A_Human1.07478203
112BCL6_27268052_Chip-Seq_Bcells_Human1.06966313
113NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05922700
114GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05291100
115FOXM1_23109430_ChIP-Seq_U2OS_Human1.05075382
116* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.04805254
117UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04207949
118IRF8_22096565_ChIP-ChIP_GC-B_Human1.03761239
119SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03717886
120* SRF_21415370_ChIP-Seq_HL-1_Mouse1.03619036
121STAT4_19710469_ChIP-ChIP_TH1__Mouse1.03371737
122KDM2B_26808549_Chip-Seq_SUP-B15_Human1.03212294
123TCF7_22412390_ChIP-Seq_EML_Mouse1.01983073
124POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.01715318
125* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.00758153
126EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99299044
127TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99102866
128* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98431944
129SA1_27219007_Chip-Seq_ERYTHROID_Human0.98255540
130KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97978512
131TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.96725048
132IKZF1_21737484_ChIP-ChIP_HCT116_Human0.96397003
133RACK7_27058665_Chip-Seq_MCF-7_Human0.95614945

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.99732779
2MP0001348_abnormal_lacrimal_gland3.92283705
3MP0008260_abnormal_autophagy3.33499970
4MP0003191_abnormal_cellular_cholesterol3.22546308
5MP0008438_abnormal_cutaneous_collagen2.80970853
6MP0004147_increased_porphyrin_level2.77896010
7MP0009840_abnormal_foam_cell2.71867625
8MP0005464_abnormal_platelet_physiology2.60773078
9MP0003806_abnormal_nucleotide_metabolis2.58308256
10MP0003705_abnormal_hypodermis_morpholog2.30540876
11MP0002876_abnormal_thyroid_physiology2.23784908
12MP0002933_joint_inflammation2.17530789
13MP0000013_abnormal_adipose_tissue2.16428903
14MP0005451_abnormal_body_composition2.13577427
15MP0009333_abnormal_splenocyte_physiolog2.09113401
16MP0005671_abnormal_response_to1.98792151
17MP0003172_abnormal_lysosome_physiology1.93542144
18MP0006054_spinal_hemorrhage1.77851020
19MP0002877_abnormal_melanocyte_morpholog1.72353205
20MP0000751_myopathy1.71999038
21MP0004858_abnormal_nervous_system1.69866425
22MP0003122_maternal_imprinting1.63048323
23MP0001835_abnormal_antigen_presentation1.60208531
24MP0003075_altered_response_to1.58402363
25MP0000685_abnormal_immune_system1.54866016
26MP0001851_eye_inflammation1.50353489
27MP0002837_dystrophic_cardiac_calcinosis1.47951535
28MP0000003_abnormal_adipose_tissue1.47642369
29MP0001958_emphysema1.46847142
30MP0004084_abnormal_cardiac_muscle1.46220620
31MP0003763_abnormal_thymus_physiology1.45005715
32MP0001853_heart_inflammation1.43932547
33MP0002909_abnormal_adrenal_gland1.40605989
34MP0002396_abnormal_hematopoietic_system1.40223483
35MP0005000_abnormal_immune_tolerance1.38076502
36MP0004947_skin_inflammation1.37111187
37MP0001299_abnormal_eye_distance/1.36239630
38MP0003279_aneurysm1.35678248
39MP0005165_increased_susceptibility_to1.33016110
40MP0003866_abnormal_defecation1.32139831
41MP0010155_abnormal_intestine_physiology1.31468958
42MP0003303_peritoneal_inflammation1.31394572
43MP0002420_abnormal_adaptive_immunity1.29214177
44MP0000604_amyloidosis1.28292191
45MP0003300_gastrointestinal_ulcer1.27966690
46MP0000749_muscle_degeneration1.26956429
47MP0001845_abnormal_inflammatory_respons1.26891815
48MP0001819_abnormal_immune_cell1.26596113
49MP0003329_amyloid_beta_deposits1.25945274
50MP0000343_altered_response_to1.24301564
51MP0004272_abnormal_basement_membrane1.24201170
52MP0005257_abnormal_intraocular_pressure1.23723132
53MP0009278_abnormal_bone_marrow1.23462313
54MP0002452_abnormal_antigen_presenting1.21087450
55MP0002751_abnormal_autonomic_nervous1.21052411
56MP0005390_skeleton_phenotype1.19141395
57MP0005387_immune_system_phenotype1.14533209
58MP0001790_abnormal_immune_system1.14533209
59MP0003186_abnormal_redox_activity1.14305718
60MP0008469_abnormal_protein_level1.13301268
61MP0003123_paternal_imprinting1.12655039
62MP0002148_abnormal_hypersensitivity_rea1.11552310
63MP0002398_abnormal_bone_marrow1.11457264
64MP0001986_abnormal_taste_sensitivity1.11426515
65MP0004043_abnormal_pH_regulation1.10541390
66MP0001533_abnormal_skeleton_physiology1.10193983
67MP0000465_gastrointestinal_hemorrhage1.09876651
68MP0003448_altered_tumor_morphology1.07660421
69MP0002723_abnormal_immune_serum1.06592276
70MP0006082_CNS_inflammation1.03361627
71MP0002132_abnormal_respiratory_system1.03098018
72MP0003566_abnormal_cell_adhesion1.02177744
73MP0004808_abnormal_hematopoietic_stem1.01421137
74MP0000716_abnormal_immune_system1.01362775
75MP0000689_abnormal_spleen_morphology1.00330343
76MP0002405_respiratory_system_inflammati0.99983636
77MP0003436_decreased_susceptibility_to0.99436575
78MP0000703_abnormal_thymus_morphology0.98837789
79MP0002896_abnormal_bone_mineralization0.98458553
80MP0001800_abnormal_humoral_immune0.98327119
81MP0001661_extended_life_span0.97765530
82MP0002060_abnormal_skin_morphology0.95727050
83MP0004510_myositis0.94380495
84MP0002429_abnormal_blood_cell0.94347443
85MP0000490_abnormal_crypts_of0.93999840
86MP0008007_abnormal_cellular_replicative0.93585314
87MP0002653_abnormal_ependyma_morphology0.93405815
88MP0002419_abnormal_innate_immunity0.92565908
89MP0005025_abnormal_response_to0.92213468
90MP0001243_abnormal_dermal_layer0.91783206
91MP0000681_abnormal_thyroid_gland0.90274640
92MP0003183_abnormal_peptide_metabolism0.89644619
93MP0005501_abnormal_skin_physiology0.88860986
94MP0003724_increased_susceptibility_to0.88097448
95MP0002722_abnormal_immune_system0.87683365
96MP0001664_abnormal_digestion0.86970363
97MP0010030_abnormal_orbit_morphology0.85898276
98MP0004233_abnormal_muscle_weight0.84617924
99MP0000858_altered_metastatic_potential0.84582484
100MP0003221_abnormal_cardiomyocyte_apopto0.84511559
101MP0005623_abnormal_meninges_morphology0.83697403
102MP0009763_increased_sensitivity_to0.83415416
103MP0008932_abnormal_embryonic_tissue0.83389817
104MP0005310_abnormal_salivary_gland0.82941295
105MP0005275_abnormal_skin_tensile0.82834335
106MP0005166_decreased_susceptibility_to0.81777407
107MP0003453_abnormal_keratinocyte_physiol0.81617403
108MP0006036_abnormal_mitochondrial_physio0.80533251
109MP0004185_abnormal_adipocyte_glucose0.80379712
110MP0005023_abnormal_wound_healing0.80082811
111MP0004036_abnormal_muscle_relaxation0.79856065
112MP0000733_abnormal_muscle_development0.77561145
113MP0009764_decreased_sensitivity_to0.77485958
114MP0003634_abnormal_glial_cell0.77299451
115MP0009384_cardiac_valve_regurgitation0.76800728
116MP0005503_abnormal_tendon_morphology0.76290748
117MP0003091_abnormal_cell_migration0.75666936
118MP0001270_distended_abdomen0.75502170
119MP0009785_altered_susceptibility_to0.75460985
120MP0005397_hematopoietic_system_phenotyp0.74801867
121MP0001545_abnormal_hematopoietic_system0.74801867
122MP0005621_abnormal_cell_physiology0.74752510
123MP0002019_abnormal_tumor_incidence0.74476190
124MP0002089_abnormal_postnatal_growth/wei0.74317560
125MP0002166_altered_tumor_susceptibility0.73979766
126MP0005584_abnormal_enzyme/coenzyme_acti0.73669213
127MP0002295_abnormal_pulmonary_circulatio0.73239186
128MP0000358_abnormal_cell_content/0.72676409
129MP0000750_abnormal_muscle_regeneration0.71075993
130MP0001849_ear_inflammation0.70433883
131MP0001542_abnormal_bone_strength0.67878744
132MP0004134_abnormal_chest_morphology0.67724875
133MP0008789_abnormal_olfactory_epithelium0.67650182
134MP0003283_abnormal_digestive_organ0.67344153
135MP0000759_abnormal_skeletal_muscle0.67274428
136MP0003828_pulmonary_edema0.67110412
137MP0003795_abnormal_bone_structure0.66091816
138MP0009379_abnormal_foot_pigmentation0.65523575
139MP0001944_abnormal_pancreas_morphology0.63324571
140MP0000747_muscle_weakness0.61276464
141MP0000313_abnormal_cell_death0.60670146
142MP0002113_abnormal_skeleton_development0.58295077
143MP0003638_abnormal_response/metabolism_0.57995724
144MP0002998_abnormal_bone_remodeling0.57511497
145MP0003121_genomic_imprinting0.57496186

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)4.58701754
2Vacuolated lymphocytes (HP:0001922)4.34730241
3Deep palmar crease (HP:0006191)3.87993590
4Dysostosis multiplex (HP:0000943)3.79164267
5Oral leukoplakia (HP:0002745)3.53333284
6Cerebral aneurysm (HP:0004944)3.28811829
7Vertebral compression fractures (HP:0002953)3.22805960
8Abnormality of liposaccharide metabolism (HP:0010968)3.10053116
9Abnormality of glycosphingolipid metabolism (HP:0004343)3.10053116
10Abnormality of glycolipid metabolism (HP:0010969)3.10053116
11Cervical subluxation (HP:0003308)3.07236179
12Increased cerebral lipofuscin (HP:0011813)3.04924637
13Hepatocellular necrosis (HP:0001404)2.88905482
14Protrusio acetabuli (HP:0003179)2.82806658
15Progressive neurologic deterioration (HP:0002344)2.80658523
16Increased neuronal autofluorescent lipopigment (HP:0002074)2.79259758
17Mucopolysacchariduria (HP:0008155)2.73118312
18Urinary glycosaminoglycan excretion (HP:0003541)2.73118312
19Joint stiffness (HP:0001387)2.66859280
20Purpura (HP:0000979)2.65154919
21Ragged-red muscle fibers (HP:0003200)2.65046195
22IgM deficiency (HP:0002850)2.63364819
23Hepatosplenomegaly (HP:0001433)2.60932396
24Loss of speech (HP:0002371)2.60392461
25Prolonged neonatal jaundice (HP:0006579)2.59636130
26Abnormality of macrophages (HP:0004311)2.49971334
27Centrally nucleated skeletal muscle fibers (HP:0003687)2.46506330
28Short nail (HP:0001799)2.46395106
29Recurrent bacterial skin infections (HP:0005406)2.45809712
30Cerebral hypomyelination (HP:0006808)2.42583073
31Testicular atrophy (HP:0000029)2.39454796
32Hypertensive crisis (HP:0100735)2.39379747
33Abnormality of polysaccharide metabolism (HP:0011012)2.39220585
34Abnormality of glycosaminoglycan metabolism (HP:0004371)2.39220585
35Abnormality of mucopolysaccharide metabolism (HP:0011020)2.39220585
36Amyloidosis (HP:0011034)2.38785640
37Pheochromocytoma (HP:0002666)2.35572560
38Split foot (HP:0001839)2.34307312
39Entropion (HP:0000621)2.34026126
40Elevated erythrocyte sedimentation rate (HP:0003565)2.33623702
41Obstructive lung disease (HP:0006536)2.32549618
42Chronic obstructive pulmonary disease (HP:0006510)2.32549618
43Broad metatarsal (HP:0001783)2.28445013
44Hepatic necrosis (HP:0002605)2.28329708
45Ulnar deviation of the wrist (HP:0003049)2.26600951
46Microvesicular hepatic steatosis (HP:0001414)2.24730993
47Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.24638860
48Neuroendocrine neoplasm (HP:0100634)2.24563379
49Interstitial pulmonary disease (HP:0006530)2.18097572
50Mesangial abnormality (HP:0001966)2.16174512
51Distal lower limb muscle weakness (HP:0009053)2.16152439
52Rough bone trabeculation (HP:0100670)2.13732176
53Abnormal gallbladder physiology (HP:0012438)2.09927541
54Cholecystitis (HP:0001082)2.09927541
55Thrombocytosis (HP:0001894)2.08376399
56Myositis (HP:0100614)2.08032555
57Severe short stature (HP:0003510)2.07527283
58Petechiae (HP:0000967)2.05770525
59Stridor (HP:0010307)2.05731887
60Mediastinal lymphadenopathy (HP:0100721)2.05689116
61Rhabdomyolysis (HP:0003201)2.05657615
62Partial duplication of the phalanx of hand (HP:0009999)2.05495425
63Axonal loss (HP:0003447)2.05033966
64Aortic dissection (HP:0002647)2.04039396
65Dilatation of the ascending aorta (HP:0005111)2.03823128
66Premature rupture of membranes (HP:0001788)2.02774638
67Abnormality of the distal phalanges of the toes (HP:0010182)2.01258174
68Trismus (HP:0000211)1.99987677
69Partial duplication of thumb phalanx (HP:0009944)1.98666662
70Mitochondrial inheritance (HP:0001427)1.98537529
71Mildly elevated creatine phosphokinase (HP:0008180)1.97603170
72Increased serum ferritin (HP:0003281)1.97470544
73Adducted thumb (HP:0001181)1.96051054
74Achilles tendon contracture (HP:0001771)1.95309642
75Ankle contracture (HP:0006466)1.94509769
76Asymmetric septal hypertrophy (HP:0001670)1.93170019
77Emotional lability (HP:0000712)1.91700651
78Hypoplasia of the odontoid process (HP:0003311)1.91526676
79Distal upper limb amyotrophy (HP:0007149)1.91486093
80Upper limb amyotrophy (HP:0009129)1.91486093
81Recurrent abscess formation (HP:0002722)1.91038741
82Long palpebral fissure (HP:0000637)1.90768810
83Abnormal mitochondria in muscle tissue (HP:0008316)1.90140060
84Generalized amyotrophy (HP:0003700)1.90001270
85Poor head control (HP:0002421)1.89814944
86Osteolytic defects of the phalanges of the hand (HP:0009771)1.89395387
87Osteolytic defects of the hand bones (HP:0009699)1.89395387
88Increased IgM level (HP:0003496)1.88855270
89Limb-girdle muscle atrophy (HP:0003797)1.87999911
90Cardiomegaly (HP:0001640)1.87810099
91Myopathic facies (HP:0002058)1.86905849
92Hypoplasia of the pons (HP:0012110)1.86627144
93Gastrointestinal dysmotility (HP:0002579)1.86280830
94Epistaxis (HP:0000421)1.85502600
95Premature graying of hair (HP:0002216)1.85366605
96Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.84954294
97Abnormal protein glycosylation (HP:0012346)1.84644323
98Abnormal glycosylation (HP:0012345)1.84644323
99Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.84644323
100Abnormal protein N-linked glycosylation (HP:0012347)1.84644323
101Hypercortisolism (HP:0001578)1.84608745
102Reduced subcutaneous adipose tissue (HP:0003758)1.84399707
103Cellulitis (HP:0100658)1.83932977
104Striae distensae (HP:0001065)1.82055188
105Vertebral hypoplasia (HP:0008417)1.81773860
106Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.81773860
107Agammaglobulinemia (HP:0004432)1.81122664
108Abnormal trabecular bone morphology (HP:0100671)1.80974276
109Hypoplasia of the capital femoral epiphysis (HP:0003090)1.80685718
110Hypertriglyceridemia (HP:0002155)1.80076779
111Fragile skin (HP:0001030)1.80012254
112Recurrent bronchitis (HP:0002837)1.79894512
113Microretrognathia (HP:0000308)1.79385436
114Eczematoid dermatitis (HP:0000976)1.79384040
115Disproportionate short-trunk short stature (HP:0003521)1.78904228
116Blue sclerae (HP:0000592)1.78166059
117Respiratory failure (HP:0002878)1.78162620
118Abnormality of the Achilles tendon (HP:0005109)1.77750397
119Neoplasm of the peripheral nervous system (HP:0100007)1.76923282
120Chronic otitis media (HP:0000389)1.75207646
121Abnormality of the umbilical cord (HP:0010881)1.74320324
122Abnormality of the calcaneus (HP:0008364)1.74218011
123Scapular winging (HP:0003691)1.73010378
124Distal lower limb amyotrophy (HP:0008944)1.72317000
125Agitation (HP:0000713)1.72113612
126Aortic aneurysm (HP:0004942)1.71884433
127Abnormality of skeletal muscle fiber size (HP:0012084)1.71084691
128Rimmed vacuoles (HP:0003805)1.70747597
129Generalized hyperpigmentation (HP:0007440)1.69798721
130Gingivitis (HP:0000230)1.69469558
131Hypergammaglobulinemia (HP:0010702)1.69410179
132Meningitis (HP:0001287)1.68962793
133Colitis (HP:0002583)1.68807140
134Abnormality of skull ossification (HP:0002703)1.68780118
135Gastrointestinal inflammation (HP:0004386)1.68542741
136Polygenic inheritance (HP:0010982)1.68417099
137Abnormality of the odontoid process (HP:0003310)1.68206548
138Atrophic scars (HP:0001075)1.68184438
139Recurrent gram-negative bacterial infections (HP:0005420)1.68097019
140Abnormality of the nasal mucosa (HP:0000433)1.67868236
141Thoracic kyphosis (HP:0002942)1.67860044
142Gastrointestinal stroma tumor (HP:0100723)1.67730473
143Fatigue (HP:0012378)1.67376132
144Biconcave vertebral bodies (HP:0004586)1.67246624
145Recurrent skin infections (HP:0001581)1.66552257
146Coxa vara (HP:0002812)1.66449269
147Pulmonary fibrosis (HP:0002206)1.66345695
148Upper motor neuron abnormality (HP:0002127)1.66137363
149Growth hormone excess (HP:0000845)1.65812168
150Urticaria (HP:0001025)1.65568320
151Abnormality of the acetabulum (HP:0003170)1.65237169
152Myocardial infarction (HP:0001658)1.65096431
153Hand muscle atrophy (HP:0009130)1.64897566
154Abnormality of dentin (HP:0010299)1.64613247
155Long toe (HP:0010511)1.63855841
156Nonimmune hydrops fetalis (HP:0001790)1.62906237
157Gingival bleeding (HP:0000225)1.62874331
158Aplasia/Hypoplasia of the sacrum (HP:0008517)1.62792063
159Increased variability in muscle fiber diameter (HP:0003557)1.62646283
160Progressive muscle weakness (HP:0003323)1.62633629
161Congenital glaucoma (HP:0001087)1.61837725
162Platyspondyly (HP:0000926)1.61836079
163Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.61445823
164Decreased activity of mitochondrial respiratory chain (HP:0008972)1.61445823
165Systemic lupus erythematosus (HP:0002725)1.58869938
166Increased CSF lactate (HP:0002490)1.58752748

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK23.48811895
2TRIB33.42142591
3MAP2K23.29816482
4ERN13.21404402
5MAP3K103.11870372
6BRAF2.87312269
7CDC72.71437799
8TESK12.68270228
9TLK12.62518647
10NME22.45271883
11SMG12.36611296
12BLK2.30781076
13VRK22.28821636
14BUB12.25807701
15LIMK12.18611028
16PRPF4B2.04735461
17MAP4K12.04579198
18ZAP702.01827831
19IRAK31.95841836
20CAMKK21.91942374
21MAP3K121.87411019
22CDK191.84018822
23MAP3K111.82659772
24LRRK21.81462410
25KDR1.70769315
26PAK41.70490320
27ILK1.64187974
28RIPK11.59084950
29MYLK1.54372453
30PKN21.50312310
31SCYL21.47390717
32TAOK21.46129202
33DAPK31.40250678
34MAP3K31.40159461
35TTN1.39983928
36NEK11.38750887
37EEF2K1.38200891
38PRKD21.38001661
39TBK11.33977166
40TGFBR11.28178306
41PASK1.27950015
42TSSK61.24848409
43ABL21.24097273
44LMTK21.21507070
45EIF2AK11.19166097
46TGFBR21.13567639
47SIK11.12751522
48RIPK41.10107395
49KIT1.06848816
50UHMK11.05574130
51BTK1.04189468
52EPHB11.03133215
53JAK31.00682881
54MARK30.97829208
55DAPK10.95387922
56MAP3K80.92426274
57PDK20.92196757
58MOS0.90359537
59STK160.89685258
60MAP3K10.87290602
61MAPK150.86605411
62EPHA20.83348435
63WNK40.82263515
64IRAK40.82178228
65BRSK10.81658354
66CCNB10.80694585
67FES0.80120036
68CSF1R0.77760441
69FGFR40.74962919
70TYK20.73634999
71BCKDK0.72419217
72PAK10.71367334
73SIK30.70518297
74SYK0.70289394
75CDK140.69374037
76PRKD30.67587669
77ACVR1B0.66961303
78MAP2K10.66680582
79PRKG20.66434758
80PIM20.66286648
81MAP3K140.66232477
82LCK0.65966212
83PAK20.65496541
84TXK0.64187298
85STK100.64062543
86BRSK20.62938485
87NEK90.62655158
88DYRK1B0.61562636
89ITK0.61417743
90CAMKK10.61188166
91MAP3K130.60516420
92BMX0.59878246
93MAPK110.59060459
94TAOK10.58659945
95RPS6KA40.57837028
96PDPK10.57172916
97ROCK20.57053046
98MATK0.56817425
99CLK10.56294977
100FGR0.55236874
101AURKA0.54375088
102PRKD10.53396213
103IKBKB0.52059622
104PTK20.49855837
105PDGFRA0.49503957
106HIPK20.49424551
107LYN0.48270452
108IRAK20.47995504
109EIF2AK30.47367796
110RPS6KB20.47248099
111TNK20.46479038
112CDK180.46033410
113RPS6KA20.45527501
114ADRBK10.45010373
115NME10.43926437
116CDC42BPA0.42326859
117PDK10.42241754
118GRK60.41737390
119DDR20.41178009
120MARK20.41009637
121GRK50.40231425
122CASK0.40021411
123CDK150.39487338
124CDK70.39451274
125PAK30.38948047
126HCK0.38856815
127RPS6KL10.38655568
128RPS6KC10.38655568
129ARAF0.37690754
130ICK0.37316887
131CDK40.37251509
132CDK11A0.37199682
133CSK0.36671334
134CDK80.36113389
135MAPKAPK20.35879925
136MINK10.35852011
137VRK10.35387788
138MAP2K30.34588961
139PTK60.34392543
140MAPKAPK30.32774169
141IKBKE0.30765510
142PRKCD0.30661422

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.13614535
2Pentose phosphate pathway_Homo sapiens_hsa000302.42213028
3Vibrio cholerae infection_Homo sapiens_hsa051102.33225165
4Sulfur relay system_Homo sapiens_hsa041222.31652705
5Ribosome_Homo sapiens_hsa030102.30615099
6Protein export_Homo sapiens_hsa030602.29450221
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.16339255
8Proteasome_Homo sapiens_hsa030502.10027423
9Fatty acid elongation_Homo sapiens_hsa000622.02743324
10Lysosome_Homo sapiens_hsa041421.95749975
11Glycosaminoglycan degradation_Homo sapiens_hsa005311.92516902
12Oxidative phosphorylation_Homo sapiens_hsa001901.85580299
13Collecting duct acid secretion_Homo sapiens_hsa049661.82360710
14DNA replication_Homo sapiens_hsa030301.73669797
15Biosynthesis of amino acids_Homo sapiens_hsa012301.70812195
16Parkinsons disease_Homo sapiens_hsa050121.66648198
17Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.57879059
18Carbon metabolism_Homo sapiens_hsa012001.56516460
19Spliceosome_Homo sapiens_hsa030401.50859688
20Primary immunodeficiency_Homo sapiens_hsa053401.47351541
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.39325238
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.36041692
23Shigellosis_Homo sapiens_hsa051311.35958008
24Antigen processing and presentation_Homo sapiens_hsa046121.34181902
25Allograft rejection_Homo sapiens_hsa053301.33125095
26Mismatch repair_Homo sapiens_hsa034301.32238729
27Viral myocarditis_Homo sapiens_hsa054161.31852333
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.31184947
29N-Glycan biosynthesis_Homo sapiens_hsa005101.29651795
30Synaptic vesicle cycle_Homo sapiens_hsa047211.25784972
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23652486
32Base excision repair_Homo sapiens_hsa034101.21927468
33Autoimmune thyroid disease_Homo sapiens_hsa053201.19253805
34Glutathione metabolism_Homo sapiens_hsa004801.19119835
35Staphylococcus aureus infection_Homo sapiens_hsa051501.17815243
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17585839
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.17218665
38Graft-versus-host disease_Homo sapiens_hsa053321.15323208
39Pyrimidine metabolism_Homo sapiens_hsa002401.13006927
40Phagosome_Homo sapiens_hsa041451.10482788
41Legionellosis_Homo sapiens_hsa051341.05210774
42VEGF signaling pathway_Homo sapiens_hsa043701.04401013
43Alzheimers disease_Homo sapiens_hsa050101.00516250
44Bladder cancer_Homo sapiens_hsa052190.99195821
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.98893285
46Sulfur metabolism_Homo sapiens_hsa009200.97555891
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.96371403
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.95712040
49B cell receptor signaling pathway_Homo sapiens_hsa046620.95682066
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94094906
51Herpes simplex infection_Homo sapiens_hsa051680.94066443
52Chronic myeloid leukemia_Homo sapiens_hsa052200.93785324
53Thyroid cancer_Homo sapiens_hsa052160.90459908
54NF-kappa B signaling pathway_Homo sapiens_hsa040640.90439990
55Huntingtons disease_Homo sapiens_hsa050160.88439490
56Central carbon metabolism in cancer_Homo sapiens_hsa052300.88400530
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.87920492
58Pancreatic cancer_Homo sapiens_hsa052120.87430971
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.86662194
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86634661
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85015849
62Apoptosis_Homo sapiens_hsa042100.83816106
63Endocytosis_Homo sapiens_hsa041440.83319522
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.82427655
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82282841
66Rheumatoid arthritis_Homo sapiens_hsa053230.80862092
67Malaria_Homo sapiens_hsa051440.80027818
68Leishmaniasis_Homo sapiens_hsa051400.79322322
69Colorectal cancer_Homo sapiens_hsa052100.79154133
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77957371
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77509994
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75081493
73Non-small cell lung cancer_Homo sapiens_hsa052230.74185959
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73813353
75Type I diabetes mellitus_Homo sapiens_hsa049400.73804201
76Asthma_Homo sapiens_hsa053100.73240509
77Cell cycle_Homo sapiens_hsa041100.72267644
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71332049
79Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71015627
80Folate biosynthesis_Homo sapiens_hsa007900.70460814
81Pertussis_Homo sapiens_hsa051330.69247413
82Influenza A_Homo sapiens_hsa051640.68838758
83Focal adhesion_Homo sapiens_hsa045100.68188977
84T cell receptor signaling pathway_Homo sapiens_hsa046600.68150386
85Renal cell carcinoma_Homo sapiens_hsa052110.67662423
86Nucleotide excision repair_Homo sapiens_hsa034200.67018821
87Tuberculosis_Homo sapiens_hsa051520.67000395
88Hepatitis B_Homo sapiens_hsa051610.65534696
89Hepatitis C_Homo sapiens_hsa051600.65431617
90Epstein-Barr virus infection_Homo sapiens_hsa051690.64703209
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.63823853
92Toxoplasmosis_Homo sapiens_hsa051450.63701316
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63600881
94RNA degradation_Homo sapiens_hsa030180.63415468
95Viral carcinogenesis_Homo sapiens_hsa052030.62822830
96HTLV-I infection_Homo sapiens_hsa051660.61352597
97Notch signaling pathway_Homo sapiens_hsa043300.61092893
982-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60073081
99Osteoclast differentiation_Homo sapiens_hsa043800.59797391
100HIF-1 signaling pathway_Homo sapiens_hsa040660.59761144
101Salmonella infection_Homo sapiens_hsa051320.59707914
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58805425
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58109737
104TNF signaling pathway_Homo sapiens_hsa046680.57698110
105Glioma_Homo sapiens_hsa052140.57542990
106Endometrial cancer_Homo sapiens_hsa052130.57161738
107Gap junction_Homo sapiens_hsa045400.55978849
108Prion diseases_Homo sapiens_hsa050200.55900262
109Acute myeloid leukemia_Homo sapiens_hsa052210.55478498
110Galactose metabolism_Homo sapiens_hsa000520.54856547
111Sphingolipid metabolism_Homo sapiens_hsa006000.54217710
112Cardiac muscle contraction_Homo sapiens_hsa042600.53832457
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50709885
114Pyruvate metabolism_Homo sapiens_hsa006200.50269623
115Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49756964
116Maturity onset diabetes of the young_Homo sapiens_hsa049500.48242603
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48196830
118Measles_Homo sapiens_hsa051620.48149855
119RNA transport_Homo sapiens_hsa030130.48102505
120Systemic lupus erythematosus_Homo sapiens_hsa053220.47401655
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47076440
122Platelet activation_Homo sapiens_hsa046110.46355051
123Hematopoietic cell lineage_Homo sapiens_hsa046400.46306956
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45824382
125Proteoglycans in cancer_Homo sapiens_hsa052050.45777656
126Toll-like receptor signaling pathway_Homo sapiens_hsa046200.44917952
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44542985
128Intestinal immune network for IgA production_Homo sapiens_hsa046720.44041312
129Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.43493792
130Purine metabolism_Homo sapiens_hsa002300.42519868
131Drug metabolism - other enzymes_Homo sapiens_hsa009830.39317871
132Amoebiasis_Homo sapiens_hsa051460.39303058
133Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38987050
134Dilated cardiomyopathy_Homo sapiens_hsa054140.38862811
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38301560
136Fructose and mannose metabolism_Homo sapiens_hsa000510.38200254
137Alcoholism_Homo sapiens_hsa050340.37747416
138Chemokine signaling pathway_Homo sapiens_hsa040620.37713975
139Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37078060
140Small cell lung cancer_Homo sapiens_hsa052220.36033775

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