SNX18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a SH3 domain. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of molecule of bacterial origin (GO:0032490)4.92213804
2detection of external biotic stimulus (GO:0098581)3.90637747
3detection of other organism (GO:0098543)3.83534128
4modulation by symbiont of host defense response (GO:0052031)3.78444297
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.78444297
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.78444297
7positive regulation by organism of defense response of other organism involved in symbiotic interact3.78444297
8modulation by symbiont of host immune response (GO:0052553)3.78444297
9positive regulation by symbiont of host defense response (GO:0052509)3.78444297
10positive regulation of gamma-delta T cell activation (GO:0046645)3.71136226
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.70621930
12negative regulation of cell killing (GO:0031342)3.70621930
13positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.66458440
14detection of biotic stimulus (GO:0009595)3.49381574
15cell adhesion mediated by integrin (GO:0033627)3.47423326
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.45372057
17response to muramyl dipeptide (GO:0032495)3.29291652
18embryonic process involved in female pregnancy (GO:0060136)3.28120156
19detection of bacterium (GO:0016045)3.23940285
20regulation of macrophage cytokine production (GO:0010935)3.21487278
21neutrophil activation involved in immune response (GO:0002283)3.18259106
22response to laminar fluid shear stress (GO:0034616)3.16660428
23positive regulation of SMAD protein import into nucleus (GO:0060391)3.13969814
24endodermal cell differentiation (GO:0035987)3.11457070
25regulation of SMAD protein import into nucleus (GO:0060390)3.09897965
26positive regulation of receptor recycling (GO:0001921)3.06141647
27macrophage activation involved in immune response (GO:0002281)3.05682076
28regulation of interferon-beta biosynthetic process (GO:0045357)3.04296830
29apoptotic cell clearance (GO:0043277)3.01068301
30positive regulation of macrophage cytokine production (GO:0060907)2.98372524
31regulation of T-helper 2 cell differentiation (GO:0045628)2.98307726
32hypotonic response (GO:0006971)2.92209702
33regulation of integrin activation (GO:0033623)2.88399282
34protein heterotrimerization (GO:0070208)2.87696237
35production of molecular mediator involved in inflammatory response (GO:0002532)2.87281179
36positive regulation of cellular amide metabolic process (GO:0034250)2.87077540
37response to peptidoglycan (GO:0032494)2.86871897
38wound healing, spreading of epidermal cells (GO:0035313)2.86397266
39positive regulation of interferon-alpha production (GO:0032727)2.81816780
40microglial cell activation (GO:0001774)2.81163785
41antigen processing and presentation of endogenous antigen (GO:0019883)2.79357409
42collagen fibril organization (GO:0030199)2.79144809
43antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.72040129
44keratan sulfate catabolic process (GO:0042340)2.71857514
45antigen processing and presentation via MHC class Ib (GO:0002475)2.70419257
46basement membrane organization (GO:0071711)2.69921888
47negative regulation of erythrocyte differentiation (GO:0045647)2.69268766
48leukocyte aggregation (GO:0070486)2.69177536
49regulation of interferon-alpha production (GO:0032647)2.68998782
50positive regulation of p38MAPK cascade (GO:1900745)2.67541374
51neutrophil mediated immunity (GO:0002446)2.67495610
52regulation of leukocyte degranulation (GO:0043300)2.66419207
53regulation of mast cell degranulation (GO:0043304)2.64780628
54immunoglobulin mediated immune response (GO:0016064)2.63959687
55leukocyte migration involved in inflammatory response (GO:0002523)2.62297747
56germ cell migration (GO:0008354)2.60762924
57regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.59890571
58regulation of B cell receptor signaling pathway (GO:0050855)2.57738656
59regulation of gamma-delta T cell activation (GO:0046643)2.56319549
60regulation of myeloid leukocyte mediated immunity (GO:0002886)2.56296658
61stress fiber assembly (GO:0043149)2.54771072
62granulocyte activation (GO:0036230)2.53586403
63positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.52000420
64regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.51341381
65negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.50002508
66platelet-derived growth factor receptor signaling pathway (GO:0048008)2.49929693
67positive regulation vascular endothelial growth factor production (GO:0010575)2.49481593
68cytoplasmic mRNA processing body assembly (GO:0033962)2.49015877
69positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.48340584
70cortical actin cytoskeleton organization (GO:0030866)2.47797956
71cellular extravasation (GO:0045123)2.46947538
72cell migration involved in heart development (GO:0060973)2.46939303
73regulation of mast cell activation involved in immune response (GO:0033006)2.46305639
74regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.46146055
75fibroblast migration (GO:0010761)2.45876961
76nuclear pore complex assembly (GO:0051292)2.45224909
77myeloid cell activation involved in immune response (GO:0002275)2.45035971
78pinocytosis (GO:0006907)2.44590403
79antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.43580909
80neutrophil activation (GO:0042119)2.43465125
81negative regulation of type 2 immune response (GO:0002829)2.43058793
82negative regulation of granulocyte differentiation (GO:0030853)2.41847428
83wound healing, spreading of cells (GO:0044319)2.41424513
84positive regulation of mast cell activation (GO:0033005)2.40471187
85negative regulation of interleukin-12 production (GO:0032695)2.40106986
86I-kappaB phosphorylation (GO:0007252)2.39846665
87regulation of mononuclear cell migration (GO:0071675)2.38799721
88negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.38448940
89regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.37305747
90phagocytosis, engulfment (GO:0006911)2.37147997
91regulation of tolerance induction (GO:0002643)2.36206628
92myeloid leukocyte mediated immunity (GO:0002444)2.36062081
93response to fluid shear stress (GO:0034405)2.35073684
94extracellular matrix assembly (GO:0085029)2.34437197
95negative regulation of T-helper cell differentiation (GO:0045623)2.34161099
96negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.34161099
97positive regulation of heat generation (GO:0031652)2.34089858
98positive regulation of leukocyte degranulation (GO:0043302)2.33593491
99leukocyte cell-cell adhesion (GO:0007159)2.32901766
100barbed-end actin filament capping (GO:0051016)2.31405057
101respiratory burst (GO:0045730)2.29659377
102collagen metabolic process (GO:0032963)2.29604004
103substrate adhesion-dependent cell spreading (GO:0034446)2.28787483
104regulation of podosome assembly (GO:0071801)2.28060844
105skin morphogenesis (GO:0043589)2.27914687
106collagen catabolic process (GO:0030574)2.27384012
107positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.27207572
108negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.25163481
109regulation of necroptotic process (GO:0060544)2.25084926
110positive regulation of interferon-beta production (GO:0032728)2.24686167
111regulation of fever generation (GO:0031620)2.24610842
112positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.24560883
113negative regulation of lymphocyte mediated immunity (GO:0002707)2.23857032
114regulation of T cell tolerance induction (GO:0002664)2.19987710
115regulation of extracellular matrix disassembly (GO:0010715)2.19986561
116chondroitin sulfate biosynthetic process (GO:0030206)2.19363463
117fibril organization (GO:0097435)2.19349704
118phagocytosis, recognition (GO:0006910)2.19303879
119heterotypic cell-cell adhesion (GO:0034113)2.19276218
120ruffle organization (GO:0031529)2.18785834
121cytokine secretion (GO:0050663)2.17837901
122positive regulation of mast cell activation involved in immune response (GO:0033008)2.17516006
123integrin-mediated signaling pathway (GO:0007229)2.17373891
124negative regulation of fatty acid transport (GO:2000192)2.17133340
125negative regulation of B cell proliferation (GO:0030889)2.16702297
126pore complex assembly (GO:0046931)2.16129504
127B cell mediated immunity (GO:0019724)2.15551103
128hyaluronan catabolic process (GO:0030214)2.15116716
129response to host (GO:0075136)2.13816444
130response to host defenses (GO:0052200)2.13816444
131response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.13816444
132positive regulation of chemokine biosynthetic process (GO:0045080)2.13345507
133positive regulation of endothelial cell apoptotic process (GO:2000353)2.12247286
134cortical cytoskeleton organization (GO:0030865)2.12088247
135embryonic placenta development (GO:0001892)2.11827511
136macrophage activation (GO:0042116)2.11633493
137modulation by symbiont of host cellular process (GO:0044068)2.10892657
138lipopolysaccharide-mediated signaling pathway (GO:0031663)2.10628138
139regulation of vascular endothelial growth factor production (GO:0010574)2.09812336
140multicellular organismal macromolecule metabolic process (GO:0044259)2.09201371
141response to host immune response (GO:0052572)2.09034512
142response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.09034512
143positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.08693767
144natural killer cell mediated cytotoxicity (GO:0042267)2.08101694
145natural killer cell mediated immunity (GO:0002228)2.08101694
146multicellular organismal catabolic process (GO:0044243)2.07932568
147establishment of endothelial barrier (GO:0061028)2.07157758
148dermatan sulfate biosynthetic process (GO:0030208)2.06632274
149macrophage differentiation (GO:0030225)2.04879516
150positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.04417028
151protein localization to endosome (GO:0036010)2.03987954
152nuclear pore organization (GO:0006999)2.03795512
153positive regulation of protein oligomerization (GO:0032461)2.03729933
154regulation of dendritic cell antigen processing and presentation (GO:0002604)2.03173140
155positive regulation of B cell differentiation (GO:0045579)2.03008347
156pathway-restricted SMAD protein phosphorylation (GO:0060389)2.01902628
157dermatan sulfate metabolic process (GO:0030205)2.01777597

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human4.74962057
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.17224557
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.83410388
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.02787443
5IRF8_21731497_ChIP-ChIP_J774_Mouse2.95466855
6STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.89771727
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.72493539
8IRF8_27001747_Chip-Seq_BMDM_Mouse2.62029002
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.56593318
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.51370159
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.46754794
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.42662973
13E2F7_22180533_ChIP-Seq_HELA_Human2.41616680
14RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.40829171
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.40502672
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.40369448
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.36739873
18* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.34967114
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.34822793
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.25544502
21CLOCK_20551151_ChIP-Seq_293T_Human2.18774971
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.98273716
23KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.96598756
24KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.96598756
25KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.96598756
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.90134115
27HIF1A_21447827_ChIP-Seq_MCF-7_Human1.90076071
28BRD4_27068464_Chip-Seq_AML-cells_Mouse1.84965852
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.75696754
30CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.75168002
31CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.74782654
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.69279680
33ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.68218240
34SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.68132512
35TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.66844981
36SALL4_18804426_ChIP-ChIP_XEN_Mouse1.64321963
37NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.63349778
38RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.62191299
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.60246453
40FOXO3_23340844_ChIP-Seq_DLD1_Human1.58922226
41WT1_19549856_ChIP-ChIP_CCG9911_Human1.58862450
42RUNX_20019798_ChIP-Seq_JUKART_Human1.58852241
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58471319
44SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.51149775
45SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.51149775
46VDR_24763502_ChIP-Seq_THP-1_Human1.47975569
47SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.47100726
48* BRD4_25478319_ChIP-Seq_HGPS_Human1.47096735
49VDR_21846776_ChIP-Seq_THP-1_Human1.47073221
50CJUN_26792858_Chip-Seq_BT549_Human1.46631796
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.46235288
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.45799802
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.44647367
54ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.42567147
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.42025270
56TCF7_22412390_ChIP-Seq_EML_Mouse1.39813378
57PPAR_26484153_Chip-Seq_NCI-H1993_Human1.36790620
58GATA1_22025678_ChIP-Seq_K562_Human1.36321639
59VDR_24787735_ChIP-Seq_THP-1_Human1.36116728
60SCL_19346495_ChIP-Seq_HPC-7_Human1.35619209
61MYB_26560356_Chip-Seq_TH2_Human1.34418561
62MYC_22102868_ChIP-Seq_BL_Human1.33855295
63FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.33358222
64NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.32106524
65NRF2_20460467_ChIP-Seq_MEFs_Mouse1.32106524
66ESR2_21235772_ChIP-Seq_MCF-7_Human1.31111963
67THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30681351
68PU_27001747_Chip-Seq_BMDM_Mouse1.30313547
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30195998
70IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.30049870
71SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.29641562
72SOX9_24532713_ChIP-Seq_HFSC_Mouse1.28659237
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28021425
74KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27768722
75SPI1_23547873_ChIP-Seq_NB4_Human1.25879424
76TCF3_18692474_ChIP-Seq_MEFs_Mouse1.25804854
77MAF_26560356_Chip-Seq_TH1_Human1.25544765
78ESR1_20079471_ChIP-ChIP_T-47D_Human1.23598900
79TBX20_22080862_ChIP-Seq_HEART_Mouse1.23388352
80TBX20_22328084_ChIP-Seq_HEART_Mouse1.23388352
81GATA2_21666600_ChIP-Seq_HMVEC_Human1.23305814
82TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.22235084
83UBF1/2_26484160_Chip-Seq_HMECs_Human1.20998300
84BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20557639
85IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.20056656
86MYB_26560356_Chip-Seq_TH1_Human1.17611896
87WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17009789
88KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16606807
89RUNX1_22412390_ChIP-Seq_EML_Mouse1.16374838
90PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15549312
91JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15152859
92KDM2B_26808549_Chip-Seq_DND41_Human1.15130402
93PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14974018
94EP300_21415370_ChIP-Seq_HL-1_Mouse1.14500372
95FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.12576226
96CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12569375
97KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11458443
98TP53_16413492_ChIP-PET_HCT116_Human1.09456957
99KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09443511
100* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08189547
101DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07666220
102KDM2B_26808549_Chip-Seq_JURKAT_Human1.07451662
103SMAD_19615063_ChIP-ChIP_OVARY_Human1.07140856
104TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06630152
105STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05940163
106TFEB_21752829_ChIP-Seq_HELA_Human1.05779617
107PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05748988
108PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.05155921
109KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04771458
110P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04738358
111SPI1_23127762_ChIP-Seq_K562_Human1.03428669
112SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.03052429
113STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02582047
114STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02524108
115UTX_26944678_Chip-Seq_JUKART_Human1.02513499
116POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02125988
117* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.01707551
118NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01519833
119HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00799971
120EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.99447707
121JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99376896
122FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.98803557
123GATA1_19941826_ChIP-Seq_K562_Human0.98113994
124KDM2B_26808549_Chip-Seq_K562_Human0.98104834
125SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98059775
126SMC1_22415368_ChIP-Seq_MEFs_Mouse0.96270940
127EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.95793999
128SOX2_20726797_ChIP-Seq_SW620_Human0.94906846
129ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94315600
130CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93933420
131NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.92244523
132AR_21909140_ChIP-Seq_LNCAP_Human0.91681665
133E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.90438171

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.44442457
2MP0003705_abnormal_hypodermis_morpholog2.84266131
3MP0005275_abnormal_skin_tensile2.48198017
4MP0010352_gastrointestinal_tract_polyps2.39424927
5MP0005503_abnormal_tendon_morphology2.30027620
6MP0003566_abnormal_cell_adhesion2.17151911
7MP0005076_abnormal_cell_differentiation2.13060081
8MP0003436_decreased_susceptibility_to2.02174248
9MP0003303_peritoneal_inflammation2.02082330
10MP0006082_CNS_inflammation2.02066829
11MP0009278_abnormal_bone_marrow2.00583797
12MP0003279_aneurysm1.97619242
13MP0005023_abnormal_wound_healing1.89401040
14MP0004883_abnormal_blood_vessel1.88055350
15MP0008260_abnormal_autophagy1.84845522
16MP0001958_emphysema1.81380438
17MP0005058_abnormal_lysosome_morphology1.68468299
18MP0003448_altered_tumor_morphology1.64404566
19MP0002419_abnormal_innate_immunity1.62780054
20MP0001835_abnormal_antigen_presentation1.57608165
21MP0004947_skin_inflammation1.56431347
22MP0001533_abnormal_skeleton_physiology1.52161089
23MP0003091_abnormal_cell_migration1.50902959
24MP0004272_abnormal_basement_membrane1.47622227
25MP0005623_abnormal_meninges_morphology1.47211774
26MP0003300_gastrointestinal_ulcer1.47189275
27MP0002933_joint_inflammation1.46263403
28MP0002006_tumorigenesis1.44276339
29MP0005000_abnormal_immune_tolerance1.43522615
30MP0000733_abnormal_muscle_development1.43510742
31MP0002166_altered_tumor_susceptibility1.43223586
32MP0002060_abnormal_skin_morphology1.42553072
33MP0003453_abnormal_keratinocyte_physiol1.41754546
34MP0000767_abnormal_smooth_muscle1.41690105
35MP0008004_abnormal_stomach_pH1.38618200
36MP0003828_pulmonary_edema1.36593771
37MP0000343_altered_response_to1.35234085
38MP0005390_skeleton_phenotype1.33791498
39MP0010307_abnormal_tumor_latency1.32800616
40MP0002452_abnormal_antigen_presenting1.32143290
41MP0002998_abnormal_bone_remodeling1.31900611
42MP0005508_abnormal_skeleton_morphology1.31519960
43MP0005257_abnormal_intraocular_pressure1.29737384
44MP0002148_abnormal_hypersensitivity_rea1.26792510
45MP0005464_abnormal_platelet_physiology1.26041940
46MP0000858_altered_metastatic_potential1.25739787
47MP0001915_intracranial_hemorrhage1.22678640
48MP0009384_cardiac_valve_regurgitation1.21968776
49MP0006054_spinal_hemorrhage1.21706914
50MP0001243_abnormal_dermal_layer1.20445471
51MP0002405_respiratory_system_inflammati1.16687420
52MP0003172_abnormal_lysosome_physiology1.15998298
53MP0000685_abnormal_immune_system1.15180521
54MP0009785_altered_susceptibility_to1.13207056
55MP0005388_respiratory_system_phenotype1.13057253
56MP0002133_abnormal_respiratory_system1.13057253
57MP0003724_increased_susceptibility_to1.11788147
58MP0001800_abnormal_humoral_immune1.11665887
59MP0003950_abnormal_plasma_membrane1.11550744
60MP0002282_abnormal_trachea_morphology1.10380371
61MP0004808_abnormal_hematopoietic_stem1.09963383
62MP0005025_abnormal_response_to1.09774891
63MP0002877_abnormal_melanocyte_morpholog1.09096978
64MP0001851_eye_inflammation1.08345477
65MP0003690_abnormal_glial_cell1.08115361
66MP0002723_abnormal_immune_serum1.07557389
67MP0002896_abnormal_bone_mineralization1.04081663
68MP0001819_abnormal_immune_cell1.02704755
69MP0001790_abnormal_immune_system1.02570494
70MP0005387_immune_system_phenotype1.02570494
71MP0005397_hematopoietic_system_phenotyp1.01733482
72MP0001545_abnormal_hematopoietic_system1.01733482
73MP0002420_abnormal_adaptive_immunity1.01657662
74MP0002396_abnormal_hematopoietic_system0.99296658
75MP0003045_fibrosis0.99001293
76MP0008007_abnormal_cellular_replicative0.98746008
77MP0005451_abnormal_body_composition0.96686042
78MP0010368_abnormal_lymphatic_system0.95427124
79MP0001845_abnormal_inflammatory_respons0.95243897
80MP0003763_abnormal_thymus_physiology0.95129102
81MP0000569_abnormal_digit_pigmentation0.94619710
82MP0002295_abnormal_pulmonary_circulatio0.94202931
83MP0003191_abnormal_cellular_cholesterol0.94150594
84MP0009333_abnormal_splenocyte_physiolog0.93836947
85MP0010155_abnormal_intestine_physiology0.92298420
86MP0002697_abnormal_eye_size0.91944853
87MP0000604_amyloidosis0.90968672
88MP0003795_abnormal_bone_structure0.89787260
89MP0000465_gastrointestinal_hemorrhage0.88910892
90MP0005164_abnormal_response_to0.88776788
91MP0005595_abnormal_vascular_smooth0.88452234
92MP0004185_abnormal_adipocyte_glucose0.87463433
93MP0010234_abnormal_vibrissa_follicle0.87406121
94MP0009053_abnormal_anal_canal0.85783618
95MP0003941_abnormal_skin_development0.84518771
96MP0003075_altered_response_to0.84499242
97MP0001542_abnormal_bone_strength0.84380013
98MP0002092_abnormal_eye_morphology0.84196798
99MP0002168_other_aberrant_phenotype0.83672616
100MP0002113_abnormal_skeleton_development0.83512674
101MP0002108_abnormal_muscle_morphology0.82920883
102MP0005409_darkened_coat_color0.81586918
103MP0002925_abnormal_cardiovascular_devel0.81197900
104MP0004197_abnormal_fetal_growth/weight/0.80996685
105MP0004510_myositis0.80924903
106MP0005166_decreased_susceptibility_to0.80758505
107MP0002254_reproductive_system_inflammat0.80667128
108MP0002009_preneoplasia0.79904986
109MP0000249_abnormal_blood_vessel0.78696624
110MP0001853_heart_inflammation0.78552557
111MP0003567_abnormal_fetal_cardiomyocyte0.78438415
112MP0002115_abnormal_skeleton_extremities0.78375557
113MP0000432_abnormal_head_morphology0.77665990
114MP0001614_abnormal_blood_vessel0.77147716
115MP0003221_abnormal_cardiomyocyte_apopto0.76819277
116MP0003385_abnormal_body_wall0.76583468
117MP0001175_abnormal_lung_morphology0.76409232
118MP0009764_decreased_sensitivity_to0.75704703
119MP0000716_abnormal_immune_system0.72895869
120MP0002132_abnormal_respiratory_system0.72877327
121MP0004858_abnormal_nervous_system0.70971373
122MP0003183_abnormal_peptide_metabolism0.70926532
123MP0005621_abnormal_cell_physiology0.69465845
124MP0000751_myopathy0.69288809

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.10814728
2Cerebral aneurysm (HP:0004944)3.87440590
3Premature rupture of membranes (HP:0001788)3.76905989
4Eczematoid dermatitis (HP:0000976)3.55321954
5Recurrent abscess formation (HP:0002722)3.53108732
6Recurrent bacterial skin infections (HP:0005406)3.46483090
7Cervical subluxation (HP:0003308)3.21803965
8Aortic dissection (HP:0002647)3.18712347
9Aortic aneurysm (HP:0004942)3.15738787
10Peritonitis (HP:0002586)3.10400603
11Spontaneous hematomas (HP:0007420)3.06549669
12Hematochezia (HP:0002573)3.03269966
13Systemic lupus erythematosus (HP:0002725)3.02287537
14Shallow orbits (HP:0000586)3.00673290
15Ankle contracture (HP:0006466)2.96104916
16Spondylolisthesis (HP:0003302)2.89236901
17Osteolytic defects of the hand bones (HP:0009699)2.79418410
18Osteolytic defects of the phalanges of the hand (HP:0009771)2.79418410
19Arterial tortuosity (HP:0005116)2.79057983
20Vascular tortuosity (HP:0004948)2.75967557
21Mitral valve prolapse (HP:0001634)2.71963244
22Myocardial infarction (HP:0001658)2.64648939
23Vertebral compression fractures (HP:0002953)2.54760617
24Increased variability in muscle fiber diameter (HP:0003557)2.43973153
25Recurrent gram-negative bacterial infections (HP:0005420)2.43949581
26Dilatation of the ascending aorta (HP:0005111)2.41307206
27Soft skin (HP:0000977)2.40515791
28Type 1 muscle fiber predominance (HP:0003803)2.38912876
29Spinal cord lesions (HP:0100561)2.37125205
30Syringomyelia (HP:0003396)2.37125205
31Metaphyseal cupping (HP:0003021)2.35180177
32Absent frontal sinuses (HP:0002688)2.32947568
33Persistence of primary teeth (HP:0006335)2.31996685
34Genu recurvatum (HP:0002816)2.31369324
35Overgrowth (HP:0001548)2.26773907
36Blue sclerae (HP:0000592)2.21994179
37Abnormality of skeletal muscle fiber size (HP:0012084)2.21905710
38Gastrointestinal infarctions (HP:0005244)2.17611820
39Thick nail (HP:0001805)2.17273728
40Mitral stenosis (HP:0001718)2.15534441
41Elevated erythrocyte sedimentation rate (HP:0003565)2.14467928
42Wrist flexion contracture (HP:0001239)2.14446286
43Orchitis (HP:0100796)2.13371895
44Abnormality of macrophages (HP:0004311)2.12463394
45Ulnar bowing (HP:0003031)2.11437571
46Urethral obstruction (HP:0000796)2.10111805
47Wormian bones (HP:0002645)2.08681266
48Myositis (HP:0100614)2.07489419
49Increased connective tissue (HP:0009025)2.05568708
50Glomerulonephritis (HP:0000099)2.04692060
51Amyloidosis (HP:0011034)2.04650393
52Axonal loss (HP:0003447)2.03083908
53Epiphyseal dysplasia (HP:0002656)2.01717354
54Abnormality of the peritoneum (HP:0002585)1.99989210
55Camptodactyly of toe (HP:0001836)1.99870593
56Asymmetric septal hypertrophy (HP:0001670)1.99835833
57Mitral regurgitation (HP:0001653)1.98641430
58Thin bony cortex (HP:0002753)1.98225676
59Fragile skin (HP:0001030)1.97165449
60Disinhibition (HP:0000734)1.96749964
61Joint laxity (HP:0001388)1.96348489
62Increased cerebral lipofuscin (HP:0011813)1.93080803
63Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.92028672
64Bladder diverticulum (HP:0000015)1.91559310
65Atrophic scars (HP:0001075)1.90416620
66Stomatitis (HP:0010280)1.89540913
67Leukocytosis (HP:0001974)1.89228126
68Hypoplastic ischia (HP:0003175)1.89038401
69Gingival bleeding (HP:0000225)1.88737149
70Mucopolysacchariduria (HP:0008155)1.88364201
71Urinary glycosaminoglycan excretion (HP:0003541)1.88364201
72Disproportionate tall stature (HP:0001519)1.86958680
73Mediastinal lymphadenopathy (HP:0100721)1.86892609
74Broad metatarsal (HP:0001783)1.84760903
75Spinal rigidity (HP:0003306)1.84732399
76Increased neuronal autofluorescent lipopigment (HP:0002074)1.84499103
77Nephritis (HP:0000123)1.84147630
78Neonatal short-limb short stature (HP:0008921)1.83076026
79Aneurysm (HP:0002617)1.82486075
80Slender build (HP:0001533)1.82352604
81Short 4th metacarpal (HP:0010044)1.82004852
82Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.82004852
83Abnormality of the vasculature of the conjunctiva (HP:0008054)1.81832781
84T lymphocytopenia (HP:0005403)1.80088194
85Hyperextensible skin (HP:0000974)1.79851325
86Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.79228152
87Eosinophilia (HP:0001880)1.79106628
88Abnormality of glycosaminoglycan metabolism (HP:0004371)1.78340480
89Abnormality of mucopolysaccharide metabolism (HP:0011020)1.78340480
90Abnormality of polysaccharide metabolism (HP:0011012)1.78340480
91Aortic regurgitation (HP:0001659)1.78112592
92Keratoconjunctivitis sicca (HP:0001097)1.77511467
93Recurrent fungal infections (HP:0002841)1.76222497
94Abnormal platelet volume (HP:0011876)1.76137798
95Conjunctival telangiectasia (HP:0000524)1.76031392
96Abnormality of the lumbar spine (HP:0100712)1.75777247
97Abnormality of skull ossification (HP:0002703)1.74871772
98Dysostosis multiplex (HP:0000943)1.74352295
99Periodontitis (HP:0000704)1.72345730
100Polycythemia (HP:0001901)1.71814347
101Pustule (HP:0200039)1.70618813
102Increased density of long bones (HP:0006392)1.70533872
103Subacute progressive viral hepatitis (HP:0006572)1.70412973
104Abnormality of the frontal sinuses (HP:0002687)1.69858969
105Ovoid vertebral bodies (HP:0003300)1.69617202
106Thoracolumbar scoliosis (HP:0002944)1.69313502
107Optic neuritis (HP:0100653)1.68989844
108Retrobulbar optic neuritis (HP:0100654)1.68989844
109Chronic mucocutaneous candidiasis (HP:0002728)1.68546018
110Recurrent cutaneous fungal infections (HP:0011370)1.68546018
111Tibial bowing (HP:0002982)1.67958726
112Elbow flexion contracture (HP:0002987)1.67178177
113Recurrent skin infections (HP:0001581)1.66768705
114Abnormality of the ischium (HP:0003174)1.65863403
115Gingivitis (HP:0000230)1.65611282
116Agnosia (HP:0010524)1.65302301
117Hemoptysis (HP:0002105)1.64492670
118Urticaria (HP:0001025)1.64107744
119Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.63980443
120Pulmonary infiltrates (HP:0002113)1.63624253
121Asymmetry of the thorax (HP:0001555)1.63325521
122Prostate neoplasm (HP:0100787)1.61970542
123Abnormality of the acetabulum (HP:0003170)1.60922272
124Broad ribs (HP:0000885)1.60845063
125Coxa vara (HP:0002812)1.60043974
126Fused cervical vertebrae (HP:0002949)1.59934262
127Arterial thrombosis (HP:0004420)1.59296961
128Abnormal vertebral ossification (HP:0100569)1.59188142
129Vacuolated lymphocytes (HP:0001922)1.58424387
130Abnormality of liposaccharide metabolism (HP:0010968)1.58154265
131Abnormality of glycosphingolipid metabolism (HP:0004343)1.58154265
132Abnormality of glycolipid metabolism (HP:0010969)1.58154265
133Follicular hyperkeratosis (HP:0007502)1.57317128
134Biconcave vertebral bodies (HP:0004586)1.56478375
135Bicuspid aortic valve (HP:0001647)1.55807247
136Cellulitis (HP:0100658)1.55620487
137Joint stiffness (HP:0001387)1.55557339
138Coarse hair (HP:0002208)1.54697468
139Joint contractures involving the joints of the feet (HP:0100492)1.54421183
140Flexion contracture of toe (HP:0005830)1.54421183
141Platyspondyly (HP:0000926)1.53763556
142Abnormality of the nasal septum (HP:0000419)1.53452599

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR23.29632375
2PRPF4B2.96019256
3RIPK42.69320288
4EPHB12.61358543
5MAP3K142.50445198
6STK102.50042693
7DDR22.19619443
8CDK122.10064170
9PIK3CG2.07066069
10LATS12.00330844
11PKN21.96212863
12TTN1.94581550
13CSK1.82615996
14MYLK1.72625425
15STK31.70228663
16PDGFRA1.69986958
17KSR21.67187439
18TYK21.64404261
19IRAK31.63345023
20PTK61.62718077
21IRAK41.62516337
22TBK11.58146555
23CAMK1D1.53226272
24ERN11.50538452
25IKBKB1.46955681
26TXK1.43834916
27MAP3K131.40399791
28MAP3K21.39370338
29CHUK1.38294024
30GRK61.38162002
31JAK31.37918770
32CSF1R1.37804981
33PAK41.35060703
34PDGFRB1.31888547
35FES1.29970186
36TRPM71.28778708
37PIM11.26432815
38CDK61.25683234
39MAPK151.25249941
40TRIB31.25036708
41NEK91.24583750
42MAP3K61.24067115
43LRRK21.23569127
44PRKD21.22697613
45MAP3K101.21376360
46RIPK11.20777129
47JAK11.20524220
48BMX1.18553141
49GRK71.16713664
50MAP3K11.16105239
51MOS1.14800381
52BMPR21.14700367
53RPS6KA41.13582552
54MARK21.13228286
55BLK1.11120751
56IRAK21.09857451
57PAK21.07586856
58CAMK1G1.05207931
59FLT31.04633129
60MAP2K31.03178538
61CDC42BPA1.02936902
62DMPK1.02093156
63MAP3K31.00581040
64IRAK10.98973945
65AKT30.98852136
66ITK0.98622084
67FGR0.94978064
68TYRO30.94970178
69MAP4K10.94000754
70FGFR30.92430927
71STK380.92338483
72MELK0.91087258
73PTK20.90016152
74ZAP700.89130405
75DYRK1B0.88704605
76EEF2K0.87939743
77HCK0.86575358
78GSK3A0.86534454
79SGK30.84521637
80SCYL20.83498476
81LATS20.83094143
82MST40.82843924
83IKBKE0.81366138
84STK40.81009923
85MTOR0.80615624
86MAP3K70.78780403
87MAP3K80.78116058
88CLK10.76941851
89KIT0.76406798
90MATK0.76256721
91MARK30.75101818
92LCK0.74452932
93TAOK10.74192639
94TEC0.74156717
95KSR10.70503197
96WNK10.70387071
97FRK0.70122184
98MAPKAPK20.68023369
99STK38L0.67950248
100PDPK10.67695110
101ABL10.67277443
102EGFR0.66912450
103INSR0.66277421
104YES10.65329781
105JAK20.64950573
106SGK20.63922090
107SYK0.63755953
108TAOK30.63136633
109MAPK120.62495436
110RET0.62489368
111NLK0.62231578
112PBK0.60451203
113MET0.60442820
114EPHA30.59102371
115MAP3K50.58972428
116PTK2B0.58930058
117ICK0.58468934
118RAF10.58276095
119ERBB40.57754474
120TAOK20.57431847
121SIK10.56611181
122RPS6KB20.56539236
123BTK0.56253893
124STK240.55394991
125NEK20.55156926
126PIM20.55109231
127ROCK20.54736171
128RPS6KC10.54523693
129RPS6KL10.54523693
130PRKD10.53972492
131NUAK10.53894520
132RPS6KA20.53449131
133LYN0.53117976
134FGFR40.51139050
135PDK10.51097536
136CDK40.51048589
137BRSK20.50710857
138EPHA20.48937890
139CAMKK20.48242841
140MAPK70.47994756
141IGF1R0.43724335
142CDC70.43669038
143CDK70.42541094
144RPS6KA60.41922646
145CDK90.41366567

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.40230863
2Staphylococcus aureus infection_Homo sapiens_hsa051502.31831118
3Osteoclast differentiation_Homo sapiens_hsa043802.11874929
4NF-kappa B signaling pathway_Homo sapiens_hsa040641.91596963
5Malaria_Homo sapiens_hsa051441.90466118
6Legionellosis_Homo sapiens_hsa051341.86927491
7ECM-receptor interaction_Homo sapiens_hsa045121.81761721
8Small cell lung cancer_Homo sapiens_hsa052221.75187659
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.71251742
10Chronic myeloid leukemia_Homo sapiens_hsa052201.65048575
11Toxoplasmosis_Homo sapiens_hsa051451.64932493
12TNF signaling pathway_Homo sapiens_hsa046681.63611839
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.63401283
14MicroRNAs in cancer_Homo sapiens_hsa052061.61578839
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.58582150
16Adherens junction_Homo sapiens_hsa045201.58427164
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.56923125
18AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.56174214
19Focal adhesion_Homo sapiens_hsa045101.56018210
20Leukocyte transendothelial migration_Homo sapiens_hsa046701.53850554
21Antigen processing and presentation_Homo sapiens_hsa046121.50380238
22Pertussis_Homo sapiens_hsa051331.49766203
23Viral myocarditis_Homo sapiens_hsa054161.48661876
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.47621520
25Graft-versus-host disease_Homo sapiens_hsa053321.47199412
26TGF-beta signaling pathway_Homo sapiens_hsa043501.45321079
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.44458169
28Pancreatic cancer_Homo sapiens_hsa052121.43922660
29Shigellosis_Homo sapiens_hsa051311.43504378
30Apoptosis_Homo sapiens_hsa042101.43186265
31Measles_Homo sapiens_hsa051621.40732745
32Proteoglycans in cancer_Homo sapiens_hsa052051.40220352
33B cell receptor signaling pathway_Homo sapiens_hsa046621.40171339
34Amoebiasis_Homo sapiens_hsa051461.38109462
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.34042320
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.32743232
37Tuberculosis_Homo sapiens_hsa051521.32266223
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29195758
39Lysosome_Homo sapiens_hsa041421.26706950
40Salmonella infection_Homo sapiens_hsa051321.22691105
41Hepatitis B_Homo sapiens_hsa051611.21030206
42Other glycan degradation_Homo sapiens_hsa005111.20395847
43Influenza A_Homo sapiens_hsa051641.11073828
44p53 signaling pathway_Homo sapiens_hsa041151.11026210
45Prostate cancer_Homo sapiens_hsa052151.09548092
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.07360389
47Herpes simplex infection_Homo sapiens_hsa051681.06101927
48Platelet activation_Homo sapiens_hsa046111.05302558
49Notch signaling pathway_Homo sapiens_hsa043301.03268042
50Regulation of actin cytoskeleton_Homo sapiens_hsa048101.02294324
51Transcriptional misregulation in cancer_Homo sapiens_hsa052021.01420786
52Hematopoietic cell lineage_Homo sapiens_hsa046401.00588492
53Viral carcinogenesis_Homo sapiens_hsa052030.99684795
54Steroid biosynthesis_Homo sapiens_hsa001000.98715379
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.97893964
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97428077
57Acute myeloid leukemia_Homo sapiens_hsa052210.96928530
58Phagosome_Homo sapiens_hsa041450.96926710
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.93795952
60Colorectal cancer_Homo sapiens_hsa052100.93337255
61Renal cell carcinoma_Homo sapiens_hsa052110.91075855
62Chemokine signaling pathway_Homo sapiens_hsa040620.90639694
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90291072
64Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.90190383
65HTLV-I infection_Homo sapiens_hsa051660.89990964
66Thyroid cancer_Homo sapiens_hsa052160.88809606
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88532418
68Bladder cancer_Homo sapiens_hsa052190.86735681
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.86374107
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84191488
71Pathways in cancer_Homo sapiens_hsa052000.83831759
72Hippo signaling pathway_Homo sapiens_hsa043900.83712139
73T cell receptor signaling pathway_Homo sapiens_hsa046600.83275580
74PI3K-Akt signaling pathway_Homo sapiens_hsa041510.82256772
75GnRH signaling pathway_Homo sapiens_hsa049120.80968027
76RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78157486
77Inositol phosphate metabolism_Homo sapiens_hsa005620.75518858
78Prion diseases_Homo sapiens_hsa050200.75027097
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74871005
80Choline metabolism in cancer_Homo sapiens_hsa052310.74138530
81Protein digestion and absorption_Homo sapiens_hsa049740.73763024
82Autoimmune thyroid disease_Homo sapiens_hsa053200.73607280
83Dorso-ventral axis formation_Homo sapiens_hsa043200.73162854
84ErbB signaling pathway_Homo sapiens_hsa040120.72126678
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71616809
86Estrogen signaling pathway_Homo sapiens_hsa049150.71179991
87Epstein-Barr virus infection_Homo sapiens_hsa051690.70448805
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66469749
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65936443
90Lysine degradation_Homo sapiens_hsa003100.65509188
91FoxO signaling pathway_Homo sapiens_hsa040680.65498010
92Hepatitis C_Homo sapiens_hsa051600.65288984
93Complement and coagulation cascades_Homo sapiens_hsa046100.64302665
94mTOR signaling pathway_Homo sapiens_hsa041500.64227550
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.62023919
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.61475946
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61165369
98MAPK signaling pathway_Homo sapiens_hsa040100.59736295
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.59729045
100Endometrial cancer_Homo sapiens_hsa052130.59585552
101Intestinal immune network for IgA production_Homo sapiens_hsa046720.59547981
102VEGF signaling pathway_Homo sapiens_hsa043700.59377763
103Allograft rejection_Homo sapiens_hsa053300.58941752
104Insulin signaling pathway_Homo sapiens_hsa049100.58710684
105Rheumatoid arthritis_Homo sapiens_hsa053230.58577336
106Melanoma_Homo sapiens_hsa052180.57892807
107Systemic lupus erythematosus_Homo sapiens_hsa053220.57215379
108Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56270809
109Endocytosis_Homo sapiens_hsa041440.54057575
110Glioma_Homo sapiens_hsa052140.50604831
111Non-small cell lung cancer_Homo sapiens_hsa052230.50464829
112African trypanosomiasis_Homo sapiens_hsa051430.50168259
113Rap1 signaling pathway_Homo sapiens_hsa040150.48652193
114HIF-1 signaling pathway_Homo sapiens_hsa040660.48024475
115Prolactin signaling pathway_Homo sapiens_hsa049170.47593651
116Insulin resistance_Homo sapiens_hsa049310.46879790
117Cell cycle_Homo sapiens_hsa041100.44950998
118Basal cell carcinoma_Homo sapiens_hsa052170.43393608

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