ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	post-embryonic morphogenesis (GO:0009886)	9.36712248
2	response to pheromone (GO:0019236)	8.62868399
3	intestinal cholesterol absorption (GO:0030299)	6.61771206
4	regulation of rhodopsin mediated signaling pathway (GO:0022400)	6.46692641
5	very-low-density lipoprotein particle assembly (GO:0034379)	6.46049864
6	oogenesis (GO:0048477)	6.37934437
7	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	6.18267510
8	rhodopsin mediated signaling pathway (GO:0016056)	5.92934876
9	mitochondrial DNA replication (GO:0006264)	5.76944081
10	regulation of gene silencing by RNA (GO:0060966)	5.47517013
11	regulation of posttranscriptional gene silencing (GO:0060147)	5.47517013
12	regulation of gene silencing by miRNA (GO:0060964)	5.47517013
13	cellular response to zinc ion (GO:0071294)	5.31324566
14	folic acid metabolic process (GO:0046655)	5.24263313
15	short-chain fatty acid metabolic process (GO:0046459)	5.04181937
16	energy homeostasis (GO:0097009)	5.03242566
17	long term synaptic depression (GO:0060292)	4.94017009
18	chaperone mediated protein folding requiring cofactor (GO:0051085)	4.86909684
19	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.82834767
20	positive thymic T cell selection (GO:0045059)	4.82081841
21	positive regulation of endothelial cell differentiation (GO:0045603)	4.77492613
22	folic acid-containing compound biosynthetic process (GO:0009396)	4.69346810
23	synapsis (GO:0007129)	4.51670875
24	base-excision repair, AP site formation (GO:0006285)	4.28108879
25	cell wall macromolecule catabolic process (GO:0016998)	4.26340646
26	negative regulation of gene silencing (GO:0060969)	4.24230775
27	pyrimidine nucleotide catabolic process (GO:0006244)	4.15243900
28	estrogen biosynthetic process (GO:0006703)	4.14332208
29	C4-dicarboxylate transport (GO:0015740)	4.11730816
30	mitochondrial DNA metabolic process (GO:0032042)	4.10028253
31	cholesterol efflux (GO:0033344)	4.08398778
32	female gamete generation (GO:0007292)	4.00313851
33	histone H3-K9 modification (GO:0061647)	3.99553308
34	positive regulation of CREB transcription factor activity (GO:0032793)	3.98985446
35	motile cilium assembly (GO:0044458)	3.95184523
36	positive T cell selection (GO:0043368)	3.84535726
37	regulation of endothelial cell differentiation (GO:0045601)	3.71325730
38	S-adenosylmethionine metabolic process (GO:0046500)	3.69270324
39	negative regulation of cAMP-mediated signaling (GO:0043951)	3.68919532
40	antigen processing and presentation of endogenous antigen (GO:0019883)	3.56622937
41	cell wall macromolecule metabolic process (GO:0044036)	3.50485759
42	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	3.44953141
43	negative regulation of calcium ion transport into cytosol (GO:0010523)	3.44339164
44	mitochondrial genome maintenance (GO:0000002)	3.33033299
45	plasma lipoprotein particle assembly (GO:0034377)	3.29011488
46	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.25821071
47	vitamin transmembrane transport (GO:0035461)	3.20598484
48	alpha-linolenic acid metabolic process (GO:0036109)	3.16986558
49	intestinal absorption (GO:0050892)	3.15587138
50	mechanosensory behavior (GO:0007638)	3.15359667
51	collecting duct development (GO:0072044)	3.13979728
52	nephron tubule morphogenesis (GO:0072078)	3.12941648
53	nephron epithelium morphogenesis (GO:0072088)	3.12941648
54	regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)	3.11344752
55	histone H3-K9 methylation (GO:0051567)	3.10187395
56	protein-lipid complex assembly (GO:0065005)	3.08434517
57	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	3.07284631
58	termination of G-protein coupled receptor signaling pathway (GO:0038032)	3.05757933
59	regulation of G0 to G1 transition (GO:0070316)	3.00765337
60	protein prenylation (GO:0018342)	2.99668022
61	prenylation (GO:0097354)	2.99668022
62	folic acid-containing compound metabolic process (GO:0006760)	2.97617187
63	negative regulation of execution phase of apoptosis (GO:1900118)	2.95561392
64	phototransduction, visible light (GO:0007603)	2.94929659
65	thymic T cell selection (GO:0045061)	2.89815830
66	male meiosis I (GO:0007141)	2.88953826
67	negative T cell selection (GO:0043383)	2.88843938
68	mannose metabolic process (GO:0006013)	2.88078815
69	positive regulation of protein kinase C signaling (GO:0090037)	2.88050447
70	plasma lipoprotein particle organization (GO:0071827)	2.87593685
71	B cell receptor signaling pathway (GO:0050853)	2.86999700
72	negative regulation of activin receptor signaling pathway (GO:0032926)	2.83772451
73	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.82563324
74	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)	2.81830039
75	peptidyl-lysine dimethylation (GO:0018027)	2.81211027
76	regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)	2.81139441
77	outer ear morphogenesis (GO:0042473)	2.79781577
78	protein-lipid complex subunit organization (GO:0071825)	2.78880053
79	negative regulation of macroautophagy (GO:0016242)	2.78804153
80	high-density lipoprotein particle remodeling (GO:0034375)	2.77318582
81	positive regulation of guanylate cyclase activity (GO:0031284)	2.76916372
82	cytokine biosynthetic process (GO:0042089)	2.73199112
83	protein ADP-ribosylation (GO:0006471)	2.72887531
84	acetyl-CoA metabolic process (GO:0006084)	2.71267642
85	negative regulation of B cell apoptotic process (GO:0002903)	2.70080162
86	pteridine-containing compound biosynthetic process (GO:0042559)	2.69208511
87	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.68959044
88	seminiferous tubule development (GO:0072520)	2.67734592
89	phosphatidylcholine biosynthetic process (GO:0006656)	2.67712896
90	resolution of meiotic recombination intermediates (GO:0000712)	2.67222743
91	imidazole-containing compound metabolic process (GO:0052803)	2.65150294
92	negative regulation of lipid catabolic process (GO:0050995)	2.64635825
93	progesterone metabolic process (GO:0042448)	2.64427769
94	meiosis I (GO:0007127)	2.63103796
95	erythrocyte maturation (GO:0043249)	2.63050441
96	negative regulation of fatty acid metabolic process (GO:0045922)	2.62315384
97	glycerophospholipid catabolic process (GO:0046475)	2.61206529
98	detection of visible light (GO:0009584)	2.59391592
99	GPI anchor metabolic process (GO:0006505)	2.57990447
100	cell morphogenesis involved in neuron differentiation (GO:0048667)	11.0656194

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	7.83734959
2	EZH2_22144423_ChIP-Seq_EOC_Human	5.25741511
3	VDR_22108803_ChIP-Seq_LS180_Human	4.75483994
4	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	3.00227807
5	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.96043272
6	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.52881090
7	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	2.43680932
8	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.28203629
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.09736645
10	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.02368910
11	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.96768910
12	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.93408656
13	ER_23166858_ChIP-Seq_MCF-7_Human	1.92481648
14	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.89671585
15	BCAT_22108803_ChIP-Seq_LS180_Human	1.88712067
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.86791798
17	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.86089936
18	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.82817336
19	EWS_26573619_Chip-Seq_HEK293_Human	1.74914692
20	OCT4_20526341_ChIP-Seq_ESCs_Human	1.73726871
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.71169146
22	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.68930451
23	E2F1_20622854_ChIP-Seq_HELA_Human	1.62019406
24	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.61834844
25	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.60081054
26	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.57931049
27	NANOG_19829295_ChIP-Seq_ESCs_Human	1.53157090
28	SOX2_19829295_ChIP-Seq_ESCs_Human	1.53157090
29	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.47418286
30	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.47200514
31	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.46198721
32	TAF15_26573619_Chip-Seq_HEK293_Human	1.40792295
33	RAC3_21632823_ChIP-Seq_H3396_Human	1.38539938
34	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.35700949
35	RXR_22108803_ChIP-Seq_LS180_Human	1.33615673
36	DROSHA_22980978_ChIP-Seq_HELA_Human	1.30693673
37	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.29804065
38	SMAD1_18555785_Chip-Seq_ESCs_Mouse	1.28688115
39	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.28066202
40	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.27118346
41	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.27113891
42	SPI1_26923725_Chip-Seq_HPCs_Mouse	1.23963348
43	RNF2_27304074_Chip-Seq_NSC_Mouse	1.22798976
44	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.22374216
45	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.21808657
46	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.20856110
47	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.20592592
48	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.20304299
49	AR_21572438_ChIP-Seq_LNCaP_Human	1.19206256
50	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.19107524
51	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.18767441
52	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.17981028
53	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.15294195
54	STAT3_23295773_ChIP-Seq_U87_Human	1.14176320
55	RUNX2_22187159_ChIP-Seq_PCA_Human	1.12069718
56	P300_19829295_ChIP-Seq_ESCs_Human	1.12062542
57	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.11660511
58	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.10838458
59	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.09697376
60	AR_25329375_ChIP-Seq_VCAP_Human	1.09674350
61	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.08824499
62	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.08792170
63	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.06057669
64	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.04983108
65	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.04018032
66	NANOG_20526341_ChIP-Seq_ESCs_Human	1.03836754
67	IGF1R_20145208_ChIP-Seq_DFB_Human	1.03244938
68	TCF4_23295773_ChIP-Seq_U87_Human	1.02449319
69	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.02302813
70	RUNX1_27457419_Chip-Seq_LIVER_Mouse	1.00271551
71	RUNX_20019798_ChIP-Seq_JUKART_Human	0.99230228
72	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.99159579
73	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.98850987
74	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.98850987
75	HOXB7_26014856_ChIP-Seq_BT474_Human	0.97399126
76	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.97396387
77	P53_21459846_ChIP-Seq_SAOS-2_Human	0.96950937
78	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.95730811
79	PU1_27457419_Chip-Seq_LIVER_Mouse	0.95424718
80	CDX2_22108803_ChIP-Seq_LS180_Human	0.95395319
81	MYC_18940864_ChIP-ChIP_HL60_Human	0.94766628
82	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.94047913
83	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.92089297
84	TP53_22573176_ChIP-Seq_HFKS_Human	0.90716928
85	NCOR_22424771_ChIP-Seq_293T_Human	0.90148210
86	LXR_22158963_ChIP-Seq_LIVER_Mouse	0.89215060
87	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.88153018
88	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.87683049
89	P53_22387025_ChIP-Seq_ESCs_Mouse	0.87066446
90	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.86600294
91	CBP_20019798_ChIP-Seq_JUKART_Human	0.86600294
92	HTT_18923047_ChIP-ChIP_STHdh_Human	0.85909085
93	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.85873622
94	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.85481898
95	P300_27268052_Chip-Seq_Bcells_Human	0.85284407
96	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.84867552
97	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.84730710
98	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.83337322
99	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.83316005
100	BCOR_27268052_Chip-Seq_Bcells_Human	0.83120624

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	5.81285618
2	MP0006072_abnormal_retinal_apoptosis	5.30047957
3	MP0003646_muscle_fatigue	4.69262703
4	MP0004043_abnormal_pH_regulation	3.38425014
5	MP0005083_abnormal_biliary_tract	3.33225783
6	MP0003011_delayed_dark_adaptation	3.32528285
7	MP0005253_abnormal_eye_physiology	3.19285829
8	MP0003806_abnormal_nucleotide_metabolis	2.94967582
9	MP0006292_abnormal_olfactory_placode	2.84493215
10	MP0005671_abnormal_response_to	2.83758358
11	MP0005257_abnormal_intraocular_pressure	2.83039873
12	MP0005551_abnormal_eye_electrophysiolog	2.79403419
13	MP0003172_abnormal_lysosome_physiology	2.77439348
14	MP0003950_abnormal_plasma_membrane	2.49921493
15	MP0005360_urolithiasis	2.35317850
16	MP0005085_abnormal_gallbladder_physiolo	2.23106935
17	MP0001790_abnormal_immune_system	2.21393240
18	MP0005387_immune_system_phenotype	2.21393240
19	MP0010329_abnormal_lipoprotein_level	1.98756892
20	MP0005365_abnormal_bile_salt	1.88290304
21	MP0001666_abnormal_nutrient_absorption	1.87220360
22	MP0003252_abnormal_bile_duct	1.84180301
23	MP0002332_abnormal_exercise_endurance	1.75548508
24	MP0004264_abnormal_extraembryonic_tissu	1.73246930
25	MP0003638_abnormal_response/metabolism_	1.72825159
26	MP0005391_vision/eye_phenotype	1.70546360
27	MP0002095_abnormal_skin_pigmentation	1.62483979
28	MP0003195_calcinosis	1.55151808
29	MP0002139_abnormal_hepatobiliary_system	1.52539562
30	MP0008775_abnormal_heart_ventricle	1.44150646
31	MP0000372_irregular_coat_pigmentation	1.43518177
32	MP0004036_abnormal_muscle_relaxation	1.43429601
33	MP0001293_anophthalmia	1.42964027
34	MP0005670_abnormal_white_adipose	1.42131886
35	MP0003656_abnormal_erythrocyte_physiolo	1.40843614
36	MP0000685_abnormal_immune_system	1.40573378
37	MP0001873_stomach_inflammation	1.36095230
38	MP0002876_abnormal_thyroid_physiology	1.32018996
39	MP0005171_absent_coat_pigmentation	1.28025387
40	MP0004381_abnormal_hair_follicle	1.20243631
41	MP0002210_abnormal_sex_determination	1.16210271
42	MP0008995_early_reproductive_senescence	1.15639131
43	MP0008875_abnormal_xenobiotic_pharmacok	1.09899942
44	MP0005195_abnormal_posterior_eye	1.07152181
45	MP0001929_abnormal_gametogenesis	1.05379947
46	MP0002009_preneoplasia	1.04373567
47	MP0003890_abnormal_embryonic-extraembry	1.04096755
48	MP0001986_abnormal_taste_sensitivity	1.02599691
49	MP0001919_abnormal_reproductive_system	1.01460123
50	MP0002837_dystrophic_cardiac_calcinosis	1.00202036
51	MP0004147_increased_porphyrin_level	0.98451453
52	MP0000613_abnormal_salivary_gland	0.97491789
53	MP0005187_abnormal_penis_morphology	0.95572216
54	MP0000653_abnormal_sex_gland	0.94248596
55	MP0003698_abnormal_male_reproductive	0.93808102
56	MP0010386_abnormal_urinary_bladder	0.93394140
57	MP0005408_hypopigmentation	0.91590679
58	MP0001835_abnormal_antigen_presentation	0.89975288
59	MP0000639_abnormal_adrenal_gland	0.89570216
60	MP0001145_abnormal_male_reproductive	0.86928012
61	MP0002138_abnormal_hepatobiliary_system	0.86124809
62	MP0002229_neurodegeneration	0.85788765
63	MP0001800_abnormal_humoral_immune	0.85700981
64	MP0005410_abnormal_fertilization	0.85027243
65	MP0001968_abnormal_touch/_nociception	0.84975487
66	MP0005332_abnormal_amino_acid	0.83895201
67	MP0000609_abnormal_liver_physiology	0.83837884
68	MP0004084_abnormal_cardiac_muscle	0.82674693
69	MP0005645_abnormal_hypothalamus_physiol	0.79608389
70	MP0003045_fibrosis	0.77592324
71	MP0002736_abnormal_nociception_after	0.77363082
72	MP0004272_abnormal_basement_membrane	0.75709031
73	MP0002733_abnormal_thermal_nociception	0.74781012
74	MP0001119_abnormal_female_reproductive	0.74398640
75	MP0005389_reproductive_system_phenotype	0.73311840
76	MP0000681_abnormal_thyroid_gland	0.73288677
77	MP0005266_abnormal_metabolism	0.70779320
78	MP0005646_abnormal_pituitary_gland	0.69848006
79	MP0008872_abnormal_physiological_respon	0.69830817
80	MP0002254_reproductive_system_inflammat	0.68024091
81	MP0005084_abnormal_gallbladder_morpholo	0.67809313
82	MP0002118_abnormal_lipid_homeostasis	0.66238468
83	MP0002653_abnormal_ependyma_morphology	0.65616807
84	MP0000598_abnormal_liver_morphology	0.65406531
85	MP0002557_abnormal_social/conspecific_i	0.64768874
86	MP0001764_abnormal_homeostasis	0.62098544
87	MP0003959_abnormal_lean_body	0.61804332
88	MP0001270_distended_abdomen	0.61773044
89	MP0000689_abnormal_spleen_morphology	0.60587250
90	MP0009643_abnormal_urine_homeostasis	0.60197290
91	MP0002723_abnormal_immune_serum	0.59484881
92	MP0010094_abnormal_chromosome_stability	0.59460171
93	MP0005636_abnormal_mineral_homeostasis	0.58636474
94	MP0010368_abnormal_lymphatic_system	0.57752011
95	MP0001879_abnormal_lymphatic_vessel	0.57283761
96	MP0003941_abnormal_skin_development	0.56144926
97	MP0004885_abnormal_endolymph	0.55694898
98	MP0000371_diluted_coat_color	0.53415895
99	MP0000465_gastrointestinal_hemorrhage	0.52374100
100	MP0002452_abnormal_antigen_presenting	0.51329283

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Agammaglobulinemia (HP:0004432)	7.02851063
2	Progressive external ophthalmoplegia (HP:0000590)	6.17558539
3	Persistence of primary teeth (HP:0006335)	6.16760812
4	Chronic sinusitis (HP:0011109)	4.88425907
5	Supernumerary spleens (HP:0009799)	4.79345285
6	Recurrent bronchitis (HP:0002837)	4.77104231
7	Prostate neoplasm (HP:0100787)	4.08942112
8	Proximal tubulopathy (HP:0000114)	3.83903861
9	Abnormality of the proximal phalanges of the hand (HP:0009834)	3.70239962
10	Azoospermia (HP:0000027)	3.57220551
11	Pulmonary artery stenosis (HP:0004415)	3.49425194
12	Tubulointerstitial nephritis (HP:0001970)	3.40205657
13	Recurrent otitis media (HP:0000403)	3.33112125
14	Nonimmune hydrops fetalis (HP:0001790)	3.31545988
15	Protruding tongue (HP:0010808)	3.27043764
16	Prolonged partial thromboplastin time (HP:0003645)	3.10662670
17	Abnormal spermatogenesis (HP:0008669)	3.07473638
18	Recurrent pneumonia (HP:0006532)	3.06820460
19	Chronic hepatic failure (HP:0100626)	3.03962178
20	Tongue fasciculations (HP:0001308)	2.95815278
21	Hydroureter (HP:0000072)	2.89241895
22	Clumsiness (HP:0002312)	2.89174671
23	Dysphonia (HP:0001618)	2.83034722
24	Coronal craniosynostosis (HP:0004440)	2.81323213
25	Microvesicular hepatic steatosis (HP:0001414)	2.80731383
26	Glucose intolerance (HP:0000833)	2.77163536
27	Cellulitis (HP:0100658)	2.75895783
28	Muscle fibrillation (HP:0010546)	2.72830982
29	Duplication of thumb phalanx (HP:0009942)	2.69845561
30	Arthropathy (HP:0003040)	2.69381048
31	Papilloma (HP:0012740)	2.68399978
32	Verrucae (HP:0200043)	2.68399978
33	Hypergonadotropic hypogonadism (HP:0000815)	2.62304603
34	Bronchitis (HP:0012387)	2.53563695
35	Hepatocellular necrosis (HP:0001404)	2.53018396
36	Preauricular pit (HP:0004467)	2.51518870
37	Periauricular skin pits (HP:0100277)	2.51518870
38	External ophthalmoplegia (HP:0000544)	2.50128054
39	Abnormality of the renal collecting system (HP:0004742)	2.48758949
40	Abnormality of the middle phalanges of the toes (HP:0010183)	2.46163297
41	Hyperglycinemia (HP:0002154)	2.42911932
42	Annular pancreas (HP:0001734)	2.42092828
43	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.41667684
44	Bronchomalacia (HP:0002780)	2.41654030
45	Abnormal glucose tolerance (HP:0001952)	2.41186582
46	Hepatic necrosis (HP:0002605)	2.38611705
47	Deep venous thrombosis (HP:0002625)	2.30067697
48	Duplicated collecting system (HP:0000081)	2.27436604
49	Amelogenesis imperfecta (HP:0000705)	2.25712442
50	Abnormal ciliary motility (HP:0012262)	2.19459492
51	Tracheomalacia (HP:0002779)	2.19302693
52	Delayed CNS myelination (HP:0002188)	2.16689033
53	Generalized aminoaciduria (HP:0002909)	2.14652309
54	Nausea (HP:0002018)	2.14279225
55	3-Methylglutaconic aciduria (HP:0003535)	2.10439854
56	Concave nail (HP:0001598)	2.09404309
57	Abnormality of the phalanges of the hallux (HP:0010057)	2.09377570
58	Cellular immunodeficiency (HP:0005374)	2.06668607
59	Menorrhagia (HP:0000132)	2.06006881
60	Sepsis (HP:0100806)	2.05016262
61	Cerebral palsy (HP:0100021)	2.00542595
62	Natal tooth (HP:0000695)	2.00462253
63	Torticollis (HP:0000473)	2.00286086
64	Flared iliac wings (HP:0002869)	2.00061495
65	Congenital stationary night blindness (HP:0007642)	10.4812673
66	Abnormality of the prostate (HP:0008775)	1.97758348
67	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.95312854
68	Absent/shortened dynein arms (HP:0200106)	1.95312854
69	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	1.94927140
70	Pancreatic cysts (HP:0001737)	1.90745960
71	Type I transferrin isoform profile (HP:0003642)	1.89888447
72	Nonprogressive disorder (HP:0003680)	1.86008796
73	Increased corneal curvature (HP:0100692)	1.86006756
74	Keratoconus (HP:0000563)	1.86006756
75	Genetic anticipation (HP:0003743)	1.83737686
76	Portal hypertension (HP:0001409)	1.81371027
77	Recurrent lower respiratory tract infections (HP:0002783)	1.81154192
78	Abnormality of saccadic eye movements (HP:0000570)	1.77523147
79	Skin pits (HP:0100276)	1.77028024
80	Premature ovarian failure (HP:0008209)	1.75108614
81	Abnormality of the diencephalon (HP:0010662)	1.75022665
82	Hypokinesia (HP:0002375)	1.74626926
83	Abnormality of the columella (HP:0009929)	1.73842780
84	Prolonged bleeding time (HP:0003010)	1.73115133
85	Abolished electroretinogram (ERG) (HP:0000550)	1.72714352
86	Transposition of the great arteries (HP:0001669)	1.71164290
87	Abnormal connection of the cardiac segments (HP:0011545)	1.71164290
88	Abnormal ventriculo-arterial connection (HP:0011563)	1.71164290
89	IgG deficiency (HP:0004315)	1.70690990
90	Toxemia of pregnancy (HP:0100603)	1.69994366
91	Abnormality of DNA repair (HP:0003254)	1.69915951
92	Central scotoma (HP:0000603)	1.69752006
93	Type 2 muscle fiber atrophy (HP:0003554)	1.69552103
94	Dehydration (HP:0001944)	1.66690233
95	Abnormality of the hepatic vasculature (HP:0006707)	1.65969361
96	Osteomyelitis (HP:0002754)	1.65453064
97	Enlarged kidneys (HP:0000105)	1.65046133
98	Abnormality of male internal genitalia (HP:0000022)	1.64348090
99	Gonadotropin excess (HP:0000837)	1.64337929
100	Hyperkalemia (HP:0002153)	1.64305917

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	GRK1	5.76411825
2	MAP3K13	2.75440935
3	TESK2	14.3648517
4	EIF2AK1	1.93425159
5	TAOK3	1.90364768
6	MAPKAPK3	1.87004666
7	ICK	1.67992376
8	SIK3	1.54483770
9	ZAK	1.52265128
10	WNK4	1.33123759
11	KDR	1.24978899
12	ACVR1B	1.18311301
13	SIK2	1.15127275
14	SIK1	1.12569260
15	MARK3	1.01970722
16	EIF2AK3	0.99339623
17	TAF1	0.98429671
18	TYK2	0.97650178
19	MAPK15	0.93587904
20	MAP3K11	0.89285759
21	CAMK1D	0.87001692
22	TYRO3	0.78575577
23	ITK	0.78029481
24	CCNB1	0.76576518
25	MAP4K1	0.74343728
26	MAP4K2	0.70256778
27	SYK	0.62904406
28	STK16	0.62469795
29	BMPR2	0.59783248
30	ADRBK2	0.59620526
31	MST4	0.51962500
32	CAMK1G	0.50276132
33	FRK	0.48399120
34	DAPK1	0.42954921
35	RIPK1	0.42555048
36	IRAK1	0.42497329
37	TRPM7	0.41794257
38	SCYL2	0.41392330
39	CDK7	0.38951358
40	MAP3K7	0.37878721
41	CAMK2B	0.37241335
42	PKN2	0.37082313
43	MAPK11	0.35190915
44	PRKCI	0.34591437
45	CAMK2D	0.33258364
46	INSRR	0.33189824
47	CLK1	0.31968326
48	TNK2	0.30981236
49	RIPK4	0.29860335
50	FGFR2	0.28730445
51	LYN	0.28497047
52	MKNK1	0.27767202
53	PRKAA2	0.27524936
54	MAP3K14	0.26668783
55	PRKCQ	0.25775752
56	CAMKK1	0.23037444
57	RPS6KA5	0.22533734
58	TNIK	0.21144606
59	CDK12	0.20531531
60	OBSCN	0.20379601
61	FGFR4	0.19134432
62	PRKACG	0.19003245
63	LCK	0.18985836
64	ZAP70	0.17843905
65	MKNK2	0.17359821
66	CAMK2G	0.17291771
67	PRKD1	0.16498304
68	TEC	0.15989648
69	PRKCB	0.15690279
70	AKT3	0.15411305
71	PDGFRB	0.13820426
72	BRD4	0.13723710
73	MAP3K8	0.13015147
74	MAP3K1	0.12735248
75	MAPKAPK2	0.12288289
76	PRKAA1	0.12062145
77	PRKACA	0.11922659
78	TBK1	0.11749346
79	GSK3A	0.11250077
80	ATM	0.10680458
81	WNK1	0.10646600
82	HIPK2	0.10251098
83	HCK	0.09954596
84	CSNK1A1	0.09791706
85	KSR1	0.09044246
86	FYN	0.08666003
87	IGF1R	0.08378630
88	CAMK2A	0.08282830
89	FGFR3	0.07867394
90	CSK	0.07556977
91	PIK3CG	0.07547085
92	SRPK1	0.07015251
93	PDPK1	0.06616883
94	IRAK4	0.06241202
95	IKBKE	0.05656830
96	BMX	0.05223272
97	SGK1	0.05134702
98	INSR	0.04790140
99	KSR2	0.04128850
100	CHEK2	0.03494988

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	7.46625623
2	Steroid biosynthesis_Homo sapiens_hsa00100	3.69213905
3	One carbon pool by folate_Homo sapiens_hsa00670	3.28689988
4	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.24184540
5	Propanoate metabolism_Homo sapiens_hsa00640	2.70546529
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.49626270
7	Primary immunodeficiency_Homo sapiens_hsa05340	2.48673504
8	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.41124956
9	Nitrogen metabolism_Homo sapiens_hsa00910	2.33883681
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.20598944
11	Linoleic acid metabolism_Homo sapiens_hsa00591	2.20340709
12	Ovarian steroidogenesis_Homo sapiens_hsa04913	2.02516737
13	ABC transporters_Homo sapiens_hsa02010	1.95613514
14	Other glycan degradation_Homo sapiens_hsa00511	1.93733943
15	Mineral absorption_Homo sapiens_hsa04978	1.86884363
16	Complement and coagulation cascades_Homo sapiens_hsa04610	1.68229800
17	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.67792159
18	Retinol metabolism_Homo sapiens_hsa00830	1.49494407
19	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.48799896
20	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.41404884
21	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.41192483
22	Ether lipid metabolism_Homo sapiens_hsa00565	1.38950168
23	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.37981820
24	Antigen processing and presentation_Homo sapiens_hsa04612	1.25472211
25	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.25229442
26	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.19531027
27	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.14537696
28	Olfactory transduction_Homo sapiens_hsa04740	1.12474034
29	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.10171817
30	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.10006698
31	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.07317781
32	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.06050807
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.04909125
34	Chemical carcinogenesis_Homo sapiens_hsa05204	1.01618306
35	Bile secretion_Homo sapiens_hsa04976	1.01368265
36	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.01207077
37	PPAR signaling pathway_Homo sapiens_hsa03320	1.00062991
38	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.98453764
39	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.93156129
40	Graft-versus-host disease_Homo sapiens_hsa05332	0.88161395
41	Pyruvate metabolism_Homo sapiens_hsa00620	0.86468521
42	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.84299714
43	Salivary secretion_Homo sapiens_hsa04970	0.80995972
44	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.80951303
45	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.78494141
46	Asthma_Homo sapiens_hsa05310	0.76994309
47	Type I diabetes mellitus_Homo sapiens_hsa04940	0.74780299
48	Glutamatergic synapse_Homo sapiens_hsa04724	0.72520554
49	Fanconi anemia pathway_Homo sapiens_hsa03460	0.71759295
50	Allograft rejection_Homo sapiens_hsa05330	0.71373236
51	Lysine degradation_Homo sapiens_hsa00310	0.71266905
52	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.69701580
53	Fatty acid elongation_Homo sapiens_hsa00062	0.69108388
54	Butanoate metabolism_Homo sapiens_hsa00650	0.68943836
55	Glutathione metabolism_Homo sapiens_hsa00480	0.65813825
56	Calcium signaling pathway_Homo sapiens_hsa04020	0.64877880
57	Fatty acid metabolism_Homo sapiens_hsa01212	0.61271529
58	Taste transduction_Homo sapiens_hsa04742	0.61110880
59	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.60256215
60	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.59882874
61	Serotonergic synapse_Homo sapiens_hsa04726	0.57124918
62	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.56384599
63	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.52140010
64	Morphine addiction_Homo sapiens_hsa05032	0.51202966
65	Sphingolipid metabolism_Homo sapiens_hsa00600	0.50231797
66	Circadian rhythm_Homo sapiens_hsa04710	0.45375967
67	Histidine metabolism_Homo sapiens_hsa00340	0.44966043
68	Protein export_Homo sapiens_hsa03060	0.44474023
69	Metabolic pathways_Homo sapiens_hsa01100	0.43672609
70	Renin secretion_Homo sapiens_hsa04924	0.42547936
71	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.42380562
72	Glycerolipid metabolism_Homo sapiens_hsa00561	0.42263821
73	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.39978077
74	Basal transcription factors_Homo sapiens_hsa03022	0.39889237
75	Fat digestion and absorption_Homo sapiens_hsa04975	0.39874820
76	Prion diseases_Homo sapiens_hsa05020	0.39003154
77	Choline metabolism in cancer_Homo sapiens_hsa05231	0.36835328
78	Homologous recombination_Homo sapiens_hsa03440	0.36456747
79	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.34702164
80	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.34327995
81	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.33338784
82	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.30899596
83	Chemokine signaling pathway_Homo sapiens_hsa04062	0.30544214
84	Purine metabolism_Homo sapiens_hsa00230	0.30148635
85	GABAergic synapse_Homo sapiens_hsa04727	0.29214162
86	VEGF signaling pathway_Homo sapiens_hsa04370	0.29172340
87	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.28304455
88	Circadian entrainment_Homo sapiens_hsa04713	0.27228423
89	Sulfur metabolism_Homo sapiens_hsa00920	0.26996977
90	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.26622736
91	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.26257657
92	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.25319976
93	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.25122465
94	Nucleotide excision repair_Homo sapiens_hsa03420	0.24918386
95	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.24162588
96	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.22854403
97	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.21897799
98	Peroxisome_Homo sapiens_hsa04146	0.21760663
99	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.21584727
100	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.17667164

SNX18P10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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