ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	notochord development (GO:0030903)	8.03416294
2	peristalsis (GO:0030432)	6.19199586
3	regulation of somitogenesis (GO:0014807)	5.95231030
4	vitamin transmembrane transport (GO:0035461)	5.42168390
5	regulation of gene silencing by RNA (GO:0060966)	5.20493886
6	regulation of posttranscriptional gene silencing (GO:0060147)	5.20493886
7	regulation of gene silencing by miRNA (GO:0060964)	5.20493886
8	urinary tract smooth muscle contraction (GO:0014848)	5.00435751
9	import into cell (GO:0098657)	4.86736084
10	inner cell mass cell proliferation (GO:0001833)	4.79435643
11	flavonoid metabolic process (GO:0009812)	4.40659105
12	iron ion import (GO:0097286)	4.38052299
13	negative regulation of fibrinolysis (GO:0051918)	4.22986075
14	regulation of establishment of cell polarity (GO:2000114)	4.18210097
15	regulation of hydrogen peroxide metabolic process (GO:0010310)	4.14012514
16	cell morphogenesis involved in neuron differentiation (GO:0048667)	4.13672921
17	dorsal/ventral axis specification (GO:0009950)	4.05596292
18	very-low-density lipoprotein particle assembly (GO:0034379)	4.04319253
19	sulfation (GO:0051923)	3.96079015
20	positive regulation of fatty acid beta-oxidation (GO:0032000)	3.93551427
21	regulation of fatty acid beta-oxidation (GO:0031998)	3.92873711
22	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.92061320
23	regulation of chromatin binding (GO:0035561)	3.87170164
24	regulation of hippo signaling (GO:0035330)	3.83211245
25	neurotransmitter catabolic process (GO:0042135)	3.72644062
26	inner ear receptor cell development (GO:0060119)	3.67766619
27	endocardial cushion development (GO:0003197)	3.63106852
28	alanine transport (GO:0032328)	3.60822160
29	cytoplasmic mRNA processing body assembly (GO:0033962)	3.59989157
30	positive regulation of DNA-dependent DNA replication (GO:2000105)	3.57264941
31	intestinal cholesterol absorption (GO:0030299)	3.50822431
32	post-embryonic morphogenesis (GO:0009886)	3.50723685
33	regulation of DNA endoreduplication (GO:0032875)	3.43844358
34	regulation of establishment or maintenance of cell polarity (GO:0032878)	3.40796468
35	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	3.40457267
36	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	3.40457267
37	nuclear pore complex assembly (GO:0051292)	3.37055105
38	L-amino acid import (GO:0043092)	3.35506895
39	pyrimidine-containing compound transmembrane transport (GO:0072531)	3.33577587
40	regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)	3.27923843
41	positive regulation of cell cycle G2/M phase transition (GO:1902751)	3.23782321
42	positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)	3.23782321
43	regulation of fibrinolysis (GO:0051917)	3.21659686
44	negative regulation of sodium ion transport (GO:0010766)	3.17380499
45	regulation of G2/M transition of mitotic cell cycle (GO:0010389)	3.13634835
46	protein targeting to vacuole (GO:0006623)	3.12769808
47	protein targeting to lysosome (GO:0006622)	3.12769808
48	establishment of protein localization to vacuole (GO:0072666)	3.12769808
49	regulation of glucose import in response to insulin stimulus (GO:2001273)	3.12206588
50	mannose metabolic process (GO:0006013)	3.11917229
51	biotin metabolic process (GO:0006768)	3.11307428
52	phasic smooth muscle contraction (GO:0014821)	3.09329487
53	cellular response to ethanol (GO:0071361)	3.07224388
54	maintenance of protein location in nucleus (GO:0051457)	3.07190002
55	positive regulation of interleukin-8 biosynthetic process (GO:0045416)	3.04747997
56	peptidyl-threonine dephosphorylation (GO:0035970)	3.03793064
57	regulation of cholesterol biosynthetic process (GO:0045540)	3.01682473
58	positive regulation of fatty acid oxidation (GO:0046321)	2.99428232
59	coenzyme A biosynthetic process (GO:0015937)	2.98750113
60	proline biosynthetic process (GO:0006561)	2.98140704
61	nuclear pore organization (GO:0006999)	2.96359046
62	plasma lipoprotein particle assembly (GO:0034377)	2.95407292
63	multicellular organismal movement (GO:0050879)	2.95104390
64	musculoskeletal movement (GO:0050881)	2.95104390
65	regulation of protein activation cascade (GO:2000257)	2.95030775
66	regulation of complement activation (GO:0030449)	2.94357957
67	ribonucleoside bisphosphate metabolic process (GO:0033875)	2.93787822
68	nucleoside bisphosphate metabolic process (GO:0033865)	2.93787822
69	purine nucleoside bisphosphate metabolic process (GO:0034032)	2.93787822
70	macroautophagy (GO:0016236)	2.93430047
71	snRNA metabolic process (GO:0016073)	2.93134899
72	regulation of cell cycle G2/M phase transition (GO:1902749)	2.92971395
73	negative regulation of macroautophagy (GO:0016242)	2.87896012
74	kynurenine metabolic process (GO:0070189)	2.86573558
75	lytic vacuole organization (GO:0080171)	2.86547097
76	lysosome organization (GO:0007040)	2.86547097
77	regulation of fatty acid oxidation (GO:0046320)	2.84963678
78	nephron epithelium morphogenesis (GO:0072088)	2.81305667
79	nephron tubule morphogenesis (GO:0072078)	2.81305667
80	regulation of apoptotic cell clearance (GO:2000425)	2.81047955
81	snRNA processing (GO:0016180)	2.77921896
82	receptor catabolic process (GO:0032801)	2.72631324
83	COPII vesicle coating (GO:0048208)	2.69050588
84	amino acid import (GO:0043090)	2.68478812
85	negative regulation of fatty acid transport (GO:2000192)	2.68472208
86	serine family amino acid catabolic process (GO:0009071)	2.67569495
87	positive regulation of transcription from RNA polymerase III promoter (GO:0045945)	2.66914965
88	histone-serine phosphorylation (GO:0035404)	2.66114936
89	synapsis (GO:0007129)	2.65922048
90	regulation of cholesterol metabolic process (GO:0090181)	2.64609789
91	labyrinthine layer development (GO:0060711)	2.63617859
92	tyrosine metabolic process (GO:0006570)	2.63048053
93	phenol-containing compound catabolic process (GO:0019336)	2.62594327
94	regulation of translational fidelity (GO:0006450)	2.62153122
95	low-density lipoprotein particle remodeling (GO:0034374)	2.61759530
96	positive regulation of protein import into nucleus, translocation (GO:0033160)	2.61206935
97	response to UV-C (GO:0010225)	2.61166736
98	regulation of phospholipid biosynthetic process (GO:0071071)	2.59466779
99	regulation of DNA damage checkpoint (GO:2000001)	2.59222271
100	plasma lipoprotein particle organization (GO:0071827)	2.58159632

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	STAT6_21828071_ChIP-Seq_BEAS2B_Human	5.77206944
2	FOXM1_23109430_ChIP-Seq_U2OS_Human	4.31373214
3	ESR1_20079471_ChIP-ChIP_T-47D_Human	3.84696647
4	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	3.31713253
5	E2F7_22180533_ChIP-Seq_HELA_Human	3.09942658
6	ESR1_15608294_ChIP-ChIP_MCF-7_Human	2.83345857
7	AR_21572438_ChIP-Seq_LNCaP_Human	2.61214662
8	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.53822658
9	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.45069450
10	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.44684623
11	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	2.44145485
12	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	2.29937960
13	FOXA2_19822575_ChIP-Seq_HepG2_Human	2.29104660
14	PPARA_22158963_ChIP-Seq_LIVER_Mouse	2.27591851
15	KDM5A_27292631_Chip-Seq_BREAST_Human	2.16105207
16	LXR_22158963_ChIP-Seq_LIVER_Mouse	2.15122799
17	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.12809419
18	IGF1R_20145208_ChIP-Seq_DFB_Human	2.09213744
19	RXR_22158963_ChIP-Seq_LIVER_Mouse	2.08776835
20	ZNF263_19887448_ChIP-Seq_K562_Human	2.02110026
21	HIF1A_21447827_ChIP-Seq_MCF-7_Human	2.01930664
22	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.94700797
23	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.93066160
24	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.91734567
25	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.82941513
26	GATA1_19941826_ChIP-Seq_K562_Human	1.81475102
27	GATA6_25053715_ChIP-Seq_YYC3_Human	1.79958845
28	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.77050880
29	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.75127361
30	E2F1_20622854_ChIP-Seq_HELA_Human	1.71653088
31	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.67560295
32	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.58366336
33	NCOR1_26117541_ChIP-Seq_K562_Human	1.57691323
34	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.56226655
35	RAC3_21632823_ChIP-Seq_H3396_Human	1.52707677
36	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.50583493
37	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.49854965
38	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.45480171
39	GATA2_19941826_ChIP-Seq_K562_Human	1.44823461
40	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	1.39124572
41	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.38349606
42	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.37795217
43	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.37460015
44	TP53_22127205_ChIP-Seq_IMR90_Human	1.32410707
45	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.32126884
46	GATA4_25053715_ChIP-Seq_YYC3_Human	1.30125602
47	P68_20966046_ChIP-Seq_HELA_Human	1.29974742
48	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.29550980
49	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.23461610
50	TCF7_22412390_ChIP-Seq_EML_Mouse	1.23244936
51	ZNF274_21170338_ChIP-Seq_K562_Hela	1.22814055
52	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.21387395
53	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.21184642
54	AHR_22903824_ChIP-Seq_MCF-7_Human	1.20230526
55	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.20048655
56	SMC4_20622854_ChIP-Seq_HELA_Human	1.19172744
57	ATF3_27146783_Chip-Seq_COLON_Human	1.19039722
58	CREB1_26743006_Chip-Seq_LNCaP_Human	1.18727383
59	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.17849246
60	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.17180746
61	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.15638772
62	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.14030337
63	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.13128426
64	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.12612477
65	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.11166630
66	RACK7_27058665_Chip-Seq_MCF-7_Human	1.10750937
67	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.10354190
68	PHF8_20622854_ChIP-Seq_HELA_Human	1.10092656
69	MYC_22102868_ChIP-Seq_BL_Human	1.08319680
70	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.06511182
71	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	1.04892262
72	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.04688875
73	FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human	1.04404815
74	CHD1_26751641_Chip-Seq_LNCaP_Human	1.04113138
75	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.03273894
76	VDR_22108803_ChIP-Seq_LS180_Human	1.02825540
77	ERA_21632823_ChIP-Seq_H3396_Human	1.02791171
78	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	1.00755034
79	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.99738928
80	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.99425943
81	XRN2_22483619_ChIP-Seq_HELA_Human	0.98461478
82	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	0.97930009
83	LXR_22292898_ChIP-Seq_THP-1_Human	0.96086190
84	AR_21909140_ChIP-Seq_LNCAP_Human	0.95081556
85	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	0.94908123
86	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.94525869
87	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.93372663
88	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.91372231
89	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	0.90117427
90	MITF_21258399_ChIP-Seq_MELANOMA_Human	0.90109847
91	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.89430115
92	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.88606093
93	DROSHA_22980978_ChIP-Seq_HELA_Human	0.88242412
94	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.87692939
95	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	0.87367878
96	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.86587063
97	ELK4_26923725_Chip-Seq_MESODERM_Mouse	0.86384437
98	TP53_23651856_ChIP-Seq_MEFs_Mouse	0.85858957
99	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	0.84356313
100	HOXB7_26014856_ChIP-Seq_BT474_Human	0.82850322

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003183_abnormal_peptide_metabolism	3.29744890
2	MP0008875_abnormal_xenobiotic_pharmacok	2.88937007
3	MP0002163_abnormal_gland_morphology	2.83070239
4	MP0005171_absent_coat_pigmentation	2.76652225
5	MP0005360_urolithiasis	2.58354397
6	MP0003950_abnormal_plasma_membrane	2.57365424
7	MP0002139_abnormal_hepatobiliary_system	2.55183043
8	MP0004134_abnormal_chest_morphology	2.52347704
9	MP0004130_abnormal_muscle_cell	2.48944845
10	MP0001661_extended_life_span	2.31204279
11	MP0003959_abnormal_lean_body	2.30306551
12	MP0005379_endocrine/exocrine_gland_phen	2.30062606
13	MP0005451_abnormal_body_composition	2.26856496
14	MP0005408_hypopigmentation	2.25094329
15	MP0003195_calcinosis	2.23311125
16	MP0004233_abnormal_muscle_weight	2.18408616
17	MP0002102_abnormal_ear_morphology	2.14272224
18	MP0005058_abnormal_lysosome_morphology	2.08332766
19	MP0002089_abnormal_postnatal_growth/wei	2.04300114
20	MP0003136_yellow_coat_color	2.02571198
21	MP0003172_abnormal_lysosome_physiology	1.94135491
22	MP0005085_abnormal_gallbladder_physiolo	1.90444405
23	MP0001986_abnormal_taste_sensitivity	1.83399730
24	MP0004185_abnormal_adipocyte_glucose	1.82786419
25	MP0010329_abnormal_lipoprotein_level	1.82049070
26	MP0005551_abnormal_eye_electrophysiolog	1.77642228
27	MP0010094_abnormal_chromosome_stability	1.66747373
28	MP0004043_abnormal_pH_regulation	1.65962888
29	MP0005365_abnormal_bile_salt	1.65305937
30	MP0003111_abnormal_nucleus_morphology	1.60244227
31	MP0005257_abnormal_intraocular_pressure	1.54840199
32	MP0003656_abnormal_erythrocyte_physiolo	1.53552257
33	MP0003123_paternal_imprinting	1.45878263
34	MP0002160_abnormal_reproductive_system	1.45494152
35	MP0004858_abnormal_nervous_system	1.44887716
36	MP0000371_diluted_coat_color	1.42926285
37	MP0000733_abnormal_muscle_development	1.42884761
38	MP0001324_abnormal_eye_pigmentation	1.42183480
39	MP0008961_abnormal_basal_metabolism	1.37924334
40	MP0005332_abnormal_amino_acid	1.37364629
41	MP0001666_abnormal_nutrient_absorption	1.36646978
42	MP0005076_abnormal_cell_differentiation	1.36403681
43	MP0005647_abnormal_sex_gland	1.35879797
44	MP0004145_abnormal_muscle_electrophysio	1.23899678
45	MP0002932_abnormal_joint_morphology	1.21037115
46	MP0009115_abnormal_fat_cell	1.19338379
47	MP0002111_abnormal_tail_morphology	1.16597989
48	MP0005220_abnormal_exocrine_pancreas	1.16120808
49	MP0002269_muscular_atrophy	1.14683449
50	MP0002118_abnormal_lipid_homeostasis	1.14067863
51	MP0000613_abnormal_salivary_gland	1.13129253
52	MP0005448_abnormal_energy_balance	1.13128061
53	MP0000609_abnormal_liver_physiology	1.08701599
54	MP0002075_abnormal_coat/hair_pigmentati	1.08131115
55	MP0003632_abnormal_nervous_system	1.05982627
56	MP0005334_abnormal_fat_pad	1.04324473
57	MP0005266_abnormal_metabolism	1.04234915
58	MP0008057_abnormal_DNA_replication	1.02673030
59	MP0009384_cardiac_valve_regurgitation	1.02556937
60	MP0005670_abnormal_white_adipose	1.01285009
61	MP0010368_abnormal_lymphatic_system	0.98039796
62	MP0003252_abnormal_bile_duct	0.97624368
63	MP0006138_congestive_heart_failure	0.97492446
64	MP0003011_delayed_dark_adaptation	0.95120903
65	MP0003890_abnormal_embryonic-extraembry	0.92569542
66	MP0005666_abnormal_adipose_tissue	0.91058641
67	MP0004147_increased_porphyrin_level	0.89858638
68	MP0003705_abnormal_hypodermis_morpholog	0.88421093
69	MP0005410_abnormal_fertilization	0.87933410
70	MP0000747_muscle_weakness	0.87697296
71	MP0002971_abnormal_brown_adipose	0.86594465
72	MP0002249_abnormal_larynx_morphology	0.86246486
73	MP0009840_abnormal_foam_cell	0.85585312
74	MP0002009_preneoplasia	0.85394367
75	MP0003868_abnormal_feces_composition	0.84293314
76	MP0000750_abnormal_muscle_regeneration	0.84111788
77	MP0008770_decreased_survivor_rate	0.83725668
78	MP0001873_stomach_inflammation	0.82940886
79	MP0001145_abnormal_male_reproductive	0.79790176
80	MP0002876_abnormal_thyroid_physiology	0.78729579
81	MP0002086_abnormal_extraembryonic_tissu	0.77784123
82	MP0005195_abnormal_posterior_eye	0.77258599
83	MP0001186_pigmentation_phenotype	0.76055727
84	MP0009697_abnormal_copulation	0.75324710
85	MP0004197_abnormal_fetal_growth/weight/	0.73941251
86	MP0004957_abnormal_blastocyst_morpholog	0.73807053
87	MP0000372_irregular_coat_pigmentation	0.72371971
88	MP0003942_abnormal_urinary_system	0.71487252
89	MP0003936_abnormal_reproductive_system	0.71025181
90	MP0008775_abnormal_heart_ventricle	0.70840221
91	MP0003698_abnormal_male_reproductive	0.70527122
92	MP0005167_abnormal_blood-brain_barrier	0.70003740
93	MP0002085_abnormal_embryonic_tissue	0.67694175
94	MP0004272_abnormal_basement_membrane	0.67099349
95	MP0005083_abnormal_biliary_tract	0.66495275
96	MP0003699_abnormal_female_reproductive	0.64921659
97	MP0003646_muscle_fatigue	0.64307250
98	MP0001544_abnormal_cardiovascular_syste	0.64184710
99	MP0005385_cardiovascular_system_phenoty	0.64184710
100	MP0003566_abnormal_cell_adhesion	0.64031804

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	5.60712336
2	Flat acetabular roof (HP:0003180)	5.47535625
3	J-shaped sella turcica (HP:0002680)	5.12177832
4	Increased neuronal autofluorescent lipopigment (HP:0002074)	4.96944329
5	Genetic anticipation (HP:0003743)	4.48388782
6	Clumsiness (HP:0002312)	4.38314143
7	Dysmetric saccades (HP:0000641)	4.32179404
8	Increased cerebral lipofuscin (HP:0011813)	4.17165472
9	Diastasis recti (HP:0001540)	4.14075213
10	Hypobetalipoproteinemia (HP:0003563)	3.75715230
11	Abnormality of the odontoid process (HP:0003310)	3.71243504
12	Tinnitus (HP:0000360)	3.66585027
13	Deformed sella turcica (HP:0002681)	3.59212406
14	Flared iliac wings (HP:0002869)	3.58927189
15	Abnormality of the lumbar spine (HP:0100712)	3.24160169
16	Abnormality of the sella turcica (HP:0002679)	3.21141341
17	Deep venous thrombosis (HP:0002625)	3.12170068
18	Urinary bladder sphincter dysfunction (HP:0002839)	3.08931045
19	Broad alveolar ridges (HP:0000187)	3.08744666
20	Spontaneous abortion (HP:0005268)	2.82993802
21	Hypoplasia of the odontoid process (HP:0003311)	2.82304657
22	Bowel incontinence (HP:0002607)	2.76511702
23	Concave nail (HP:0001598)	2.67865858
24	Thoracic kyphosis (HP:0002942)	2.63514889
25	Vertebral arch anomaly (HP:0008438)	2.62217551
26	Abnormality of the wing of the ilium (HP:0011867)	2.50655244
27	Abnormal large intestine physiology (HP:0012700)	2.49078406
28	Abnormality of the thoracic spine (HP:0100711)	2.48553450
29	Ovoid vertebral bodies (HP:0003300)	2.45448151
30	Urethral obstruction (HP:0000796)	2.45191452
31	Persistence of primary teeth (HP:0006335)	2.43691379
32	Urinary glycosaminoglycan excretion (HP:0003541)	2.41552526
33	Mucopolysacchariduria (HP:0008155)	2.41552526
34	Carpal bone hypoplasia (HP:0001498)	2.39828550
35	Confusion (HP:0001289)	2.37908426
36	Impaired smooth pursuit (HP:0007772)	2.37357234
37	Prolonged partial thromboplastin time (HP:0003645)	2.37272580
38	Protruding tongue (HP:0010808)	2.36381409
39	Proximal tubulopathy (HP:0000114)	2.35916521
40	Azoospermia (HP:0000027)	2.34078483
41	Pseudobulbar signs (HP:0002200)	2.32665151
42	Thoracolumbar scoliosis (HP:0002944)	2.32189961
43	Hydroxyprolinuria (HP:0003080)	2.29435188
44	Abnormality of proline metabolism (HP:0010907)	2.29435188
45	Acanthocytosis (HP:0001927)	2.28065835
46	Morphological abnormality of the pyramidal tract (HP:0002062)	2.27322451
47	Beaking of vertebral bodies (HP:0004568)	2.26396649
48	Hemorrhage of the eye (HP:0011885)	2.26196249
49	Progressive cerebellar ataxia (HP:0002073)	2.23900870
50	Protuberant abdomen (HP:0001538)	2.20201322
51	Hypoplastic pelvis (HP:0008839)	2.19473636
52	Anomalous pulmonary venous return (HP:0010772)	2.14748754
53	Progressive external ophthalmoplegia (HP:0000590)	2.12635619
54	Cystic liver disease (HP:0006706)	2.10776185
55	Macroorchidism (HP:0000053)	2.10461601
56	Aortic regurgitation (HP:0001659)	2.07784384
57	Abnormality of the acetabulum (HP:0003170)	2.07412807
58	Tented upper lip vermilion (HP:0010804)	2.05371369
59	Abnormality of ocular smooth pursuit (HP:0000617)	2.04694126
60	Macroglossia (HP:0000158)	2.04290166
61	Abnormality of polysaccharide metabolism (HP:0011012)	2.02285109
62	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.02285109
63	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.02285109
64	Impaired vibratory sensation (HP:0002495)	2.00286735
65	Neonatal hypoglycemia (HP:0001998)	1.99788967
66	Blue irides (HP:0000635)	1.98870636
67	Abolished electroretinogram (ERG) (HP:0000550)	1.96378502
68	Hypolipoproteinemia (HP:0010981)	1.95093969
69	Large for gestational age (HP:0001520)	1.92968393
70	Dysostosis multiplex (HP:0000943)	1.91517158
71	Self-mutilation (HP:0000742)	1.91075706
72	Homocystinuria (HP:0002156)	1.90711848
73	Abnormality of homocysteine metabolism (HP:0010919)	1.90711848
74	Short chin (HP:0000331)	1.90440330
75	True hermaphroditism (HP:0010459)	1.88236786
76	Sparse lateral eyebrow (HP:0005338)	1.87283068
77	Abnormality of glycolipid metabolism (HP:0010969)	1.86185861
78	Abnormality of liposaccharide metabolism (HP:0010968)	1.86185861
79	Abnormality of glycosphingolipid metabolism (HP:0004343)	1.86185861
80	Pancreatic cysts (HP:0001737)	1.85985651
81	Furrowed tongue (HP:0000221)	1.80760701
82	Pathologic fracture (HP:0002756)	1.78340664
83	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.76882504
84	Abnormality of the common coagulation pathway (HP:0010990)	1.75086298
85	Congenital stationary night blindness (HP:0007642)	1.74802411
86	Aplasia/Hypoplasia involving the pelvis (HP:0009103)	1.74748658
87	Heterotopia (HP:0002282)	1.73869607
88	Postural tremor (HP:0002174)	1.73232368
89	Abnormality of the pulmonary veins (HP:0011718)	1.72144432
90	External ophthalmoplegia (HP:0000544)	1.71916013
91	Hyperglycinuria (HP:0003108)	1.71265731
92	Slow saccadic eye movements (HP:0000514)	1.70228746
93	Prominent occiput (HP:0000269)	1.69462324
94	Smooth philtrum (HP:0000319)	1.69384798
95	Hypopigmentation of the fundus (HP:0007894)	1.65633469
96	Reticulocytosis (HP:0001923)	1.65627591
97	Hypoplastic scapulae (HP:0000882)	1.65615638
98	Aplasia/Hypoplasia of the scapulae (HP:0006713)	1.65615638
99	Hemiplegia (HP:0002301)	1.64261370
100	Broad palm (HP:0001169)	1.63165619

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIB3	6.34974422
2	ADRBK2	4.36327639
3	WNK4	3.80129425
4	GRK1	3.45240767
5	TESK2	3.44106458
6	CDK12	3.12996445
7	EEF2K	2.99394208
8	ICK	2.74178676
9	BRSK2	2.72401837
10	NEK2	2.71080337
11	AKT3	2.56674705
12	BLK	2.18542490
13	FGFR4	2.06106680
14	MAPKAPK3	2.03138013
15	CLK1	1.94732791
16	PRKD3	1.62543920
17	PDGFRA	1.52828404
18	EIF2AK1	1.51970774
19	FRK	1.40443069
20	WNK1	1.40437611
21	FLT3	1.31290474
22	MTOR	1.29072665
23	RIPK1	1.27086081
24	PKN2	1.26080778
25	CAMKK2	1.23189446
26	SIK1	1.19593339
27	SIK2	1.18749199
28	NME1	1.13443399
29	NEK9	1.12456651
30	PDPK1	1.08823797
31	FGFR3	1.08356239
32	MAP3K13	1.04089891
33	TRPM7	0.97494979
34	MAPK11	0.97443166
35	PRKAA2	0.94748239
36	NTRK1	0.94228197
37	RIPK4	0.93288288
38	RPS6KB2	0.91917830
39	ACVR1B	0.91219687
40	RET	0.89865250
41	BRSK1	0.88162498
42	CDK7	0.87387033
43	CAMKK1	0.85191288
44	TTN	0.85095060
45	STK3	0.84801604
46	PIK3CA	0.84289310
47	PTK6	0.83361492
48	RPS6KB1	0.82242094
49	PDK1	0.76480676
50	INSRR	0.75770735
51	LATS1	0.74616168
52	CAMK1D	0.73681423
53	MAP3K2	0.72502039
54	MET	0.71093414
55	ADRBK1	0.63447332
56	KSR2	0.57455808
57	PRKD2	0.56884980
58	CHEK1	0.56597399
59	PRKAA1	0.55932632
60	CHEK2	0.53864953
61	PTK2	0.52053255
62	ATR	0.51346344
63	MAPKAPK5	0.50633993
64	YES1	0.49997087
65	TLK1	0.49236350
66	MAP3K9	0.48625998
67	MAP3K7	0.47353109
68	CDK1	0.45268201
69	TYRO3	0.45081723
70	NEK6	0.44708443
71	BMX	0.43973104
72	BRD4	0.43429205
73	PAK2	0.43148959
74	MAP2K4	0.42593609
75	CDK2	0.41568467
76	ERBB4	0.38088856
77	AURKB	0.37881969
78	ERBB2	0.37707195
79	FGFR1	0.37395261
80	WEE1	0.37064289
81	IRAK3	0.37056365
82	HIPK2	0.36210553
83	TTK	0.36172747
84	PDGFRB	0.35933430
85	EPHA2	0.35748498
86	PTK2B	0.35253994
87	CDC42BPA	0.33447653
88	EPHA3	0.33103066
89	CCNB1	0.32475238
90	MAP2K1	0.31855703
91	SGK1	0.28733257
92	MAP2K6	0.28268623
93	FER	0.28078824
94	PRKCH	0.27522706
95	MAPK10	0.27023959
96	MAPK14	0.25724227
97	CDK4	0.25019769
98	CDK9	0.23726234
99	ATM	0.22522569
100	SYK	0.22371034

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.13401560
2	Vitamin digestion and absorption_Homo sapiens_hsa04977	2.72247976
3	One carbon pool by folate_Homo sapiens_hsa00670	2.53104486
4	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.47356386
5	Complement and coagulation cascades_Homo sapiens_hsa04610	2.34560063
6	Selenocompound metabolism_Homo sapiens_hsa00450	2.03446509
7	Nitrogen metabolism_Homo sapiens_hsa00910	1.99751561
8	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.91882280
9	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.88554767
10	Other glycan degradation_Homo sapiens_hsa00511	1.84994371
11	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.77986132
12	ABC transporters_Homo sapiens_hsa02010	1.72041925
13	Homologous recombination_Homo sapiens_hsa03440	1.65394562
14	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.58567447
15	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.52255049
16	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.52205838
17	Lysine degradation_Homo sapiens_hsa00310	1.50930654
18	Histidine metabolism_Homo sapiens_hsa00340	1.50862511
19	PPAR signaling pathway_Homo sapiens_hsa03320	1.43619745
20	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.42981875
21	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.41130163
22	Steroid biosynthesis_Homo sapiens_hsa00100	1.40670844
23	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.38262254
24	Basal transcription factors_Homo sapiens_hsa03022	1.33033720
25	Bile secretion_Homo sapiens_hsa04976	1.31396666
26	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.24090180
27	Non-small cell lung cancer_Homo sapiens_hsa05223	1.23275039
28	Melanoma_Homo sapiens_hsa05218	1.18734980
29	Phototransduction_Homo sapiens_hsa04744	1.17430233
30	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.17362848
31	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.16426266
32	Fatty acid metabolism_Homo sapiens_hsa01212	1.14110406
33	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.13826398
34	mTOR signaling pathway_Homo sapiens_hsa04150	1.13017148
35	Taste transduction_Homo sapiens_hsa04742	1.08310884
36	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.06812281
37	Pyruvate metabolism_Homo sapiens_hsa00620	1.06670271
38	Glioma_Homo sapiens_hsa05214	1.04775935
39	Insulin resistance_Homo sapiens_hsa04931	1.03550823
40	Ether lipid metabolism_Homo sapiens_hsa00565	1.01823504
41	Fatty acid degradation_Homo sapiens_hsa00071	0.98994989
42	Butanoate metabolism_Homo sapiens_hsa00650	0.98823723
43	Chemical carcinogenesis_Homo sapiens_hsa05204	0.97027061
44	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.95321330
45	VEGF signaling pathway_Homo sapiens_hsa04370	0.93135997
46	Linoleic acid metabolism_Homo sapiens_hsa00591	0.87980808
47	Small cell lung cancer_Homo sapiens_hsa05222	0.87235427
48	Choline metabolism in cancer_Homo sapiens_hsa05231	0.87108287
49	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.85941933
50	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.84167696
51	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.81995544
52	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.80633054
53	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.77750566
54	Retinol metabolism_Homo sapiens_hsa00830	0.76855868
55	Mineral absorption_Homo sapiens_hsa04978	0.74984540
56	Tyrosine metabolism_Homo sapiens_hsa00350	0.72989278
57	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.72565119
58	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.72484234
59	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.71921410
60	Calcium signaling pathway_Homo sapiens_hsa04020	0.71334979
61	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.70992687
62	AMPK signaling pathway_Homo sapiens_hsa04152	0.70898020
63	Platelet activation_Homo sapiens_hsa04611	0.70322554
64	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.70071647
65	Bladder cancer_Homo sapiens_hsa05219	0.69430236
66	ECM-receptor interaction_Homo sapiens_hsa04512	0.69399654
67	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.69286932
68	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.68822766
69	Insulin signaling pathway_Homo sapiens_hsa04910	0.67842008
70	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.67576403
71	Lysosome_Homo sapiens_hsa04142	0.65296695
72	Fanconi anemia pathway_Homo sapiens_hsa03460	0.64730416
73	Prion diseases_Homo sapiens_hsa05020	0.64633168
74	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.62468051
75	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.61741382
76	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.61584415
77	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.58218526
78	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.56709227
79	Type II diabetes mellitus_Homo sapiens_hsa04930	0.54844707
80	ErbB signaling pathway_Homo sapiens_hsa04012	0.54506024
81	MicroRNAs in cancer_Homo sapiens_hsa05206	0.50836346
82	Fat digestion and absorption_Homo sapiens_hsa04975	0.49435131
83	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.49340113
84	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.49018734
85	Nucleotide excision repair_Homo sapiens_hsa03420	0.48633140
86	Prostate cancer_Homo sapiens_hsa05215	0.47924436
87	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.47903191
88	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.45005989
89	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.44597593
90	Arginine and proline metabolism_Homo sapiens_hsa00330	0.43781898
91	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.43468444
92	Tryptophan metabolism_Homo sapiens_hsa00380	0.43426797
93	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.41903030
94	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.38909263
95	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.38296235
96	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.38202846
97	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.37832865
98	Prolactin signaling pathway_Homo sapiens_hsa04917	0.36758097
99	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.34735203
100	Thyroid cancer_Homo sapiens_hsa05216	0.34497977

SNX18P12

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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