ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of glycogen biosynthetic process (GO:0045719)	5.43618767
2	chondroitin sulfate catabolic process (GO:0030207)	5.31097360
3	COPII vesicle coating (GO:0048208)	5.01319363
4	protein K11-linked deubiquitination (GO:0035871)	4.73079352
5	C4-dicarboxylate transport (GO:0015740)	4.69769428
6	regulation of glycogen (starch) synthase activity (GO:2000465)	4.60068569
7	iron ion import (GO:0097286)	4.42136714
8	mannose metabolic process (GO:0006013)	4.37048621
9	cellular response to zinc ion (GO:0071294)	4.28621431
10	seminiferous tubule development (GO:0072520)	4.28037425
11	vitamin transmembrane transport (GO:0035461)	4.16441592
12	vitamin A metabolic process (GO:0006776)	4.14299762
13	positive regulation of transcription from RNA polymerase III promoter (GO:0045945)	4.01253024
14	regulation of energy homeostasis (GO:2000505)	3.98384797
15	response to dietary excess (GO:0002021)	3.97116373
16	negative regulation of erythrocyte differentiation (GO:0045647)	3.95634128
17	negative regulation of glycogen metabolic process (GO:0070874)	3.90393728
18	snRNA transcription (GO:0009301)	3.84195797
19	positive regulation of peptidyl-threonine phosphorylation (GO:0010800)	3.76812839
20	regulation of chromatin binding (GO:0035561)	3.75492494
21	positive regulation of cAMP-mediated signaling (GO:0043950)	3.72522976
22	monoubiquitinated protein deubiquitination (GO:0035520)	3.71509844
23	regulation of integrin activation (GO:0033623)	3.70799528
24	regulation of RNA export from nucleus (GO:0046831)	3.66176774
25	very-low-density lipoprotein particle assembly (GO:0034379)	3.61724643
26	melanin biosynthetic process (GO:0042438)	3.58853151
27	protein targeting to Golgi (GO:0000042)	3.52759252
28	melanin metabolic process (GO:0006582)	3.48816051
29	negative regulation of fibrinolysis (GO:0051918)	3.47829367
30	motile cilium assembly (GO:0044458)	3.45961879
31	establishment of protein localization to Golgi (GO:0072600)	3.44530369
32	negative regulation of cardiac muscle hypertrophy (GO:0010614)	3.43428092
33	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.42086292
34	regulation of cholesterol homeostasis (GO:2000188)	3.33786737
35	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.30866241
36	regulation of gene expression by genetic imprinting (GO:0006349)	3.30731103
37	negative regulation of amino acid transport (GO:0051956)	3.28931599
38	NLS-bearing protein import into nucleus (GO:0006607)	3.27197333
39	genetic imprinting (GO:0071514)	3.26573950
40	inner ear receptor cell differentiation (GO:0060113)	3.23944189
41	negative regulation of catenin import into nucleus (GO:0035414)	3.19382108
42	poly(A)+ mRNA export from nucleus (GO:0016973)	3.18461990
43	tyrosine metabolic process (GO:0006570)	3.11390734
44	negative regulation of glucose import (GO:0046325)	3.11015241
45	blood coagulation, intrinsic pathway (GO:0007597)	3.10878953
46	positive regulation of endothelial cell differentiation (GO:0045603)	3.10242049
47	negative regulation of execution phase of apoptosis (GO:1900118)	3.08857323
48	regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)	3.07798255
49	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)	3.07798255
50	regulation of nucleobase-containing compound transport (GO:0032239)	3.07349835
51	coenzyme A biosynthetic process (GO:0015937)	3.06941794
52	nuclear pore complex assembly (GO:0051292)	3.04780507
53	membrane tubulation (GO:0097320)	3.01568663
54	positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)	2.99991805
55	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	2.99525382
56	activation of Rac GTPase activity (GO:0032863)	2.96849178
57	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.96255974
58	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.96255974
59	regulation of translation, ncRNA-mediated (GO:0045974)	2.96255974
60	negative regulation of muscle hypertrophy (GO:0014741)	2.95673503
61	positive regulation of action potential (GO:0045760)	2.92425068
62	regulation of peptidyl-threonine phosphorylation (GO:0010799)	2.86266332
63	drinking behavior (GO:0042756)	2.83217137
64	cellular response to glucagon stimulus (GO:0071377)	2.83088224
65	preassembly of GPI anchor in ER membrane (GO:0016254)	2.82520123
66	viral mRNA export from host cell nucleus (GO:0046784)	2.81693403
67	dicarboxylic acid biosynthetic process (GO:0043650)	2.81436313
68	nitric oxide biosynthetic process (GO:0006809)	2.81223385
69	protein localization to Golgi apparatus (GO:0034067)	2.79664451
70	arginine catabolic process (GO:0006527)	2.78284428
71	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	2.77334417
72	auditory behavior (GO:0031223)	2.77068863
73	negative regulation of cardiac muscle tissue growth (GO:0055022)	2.76442675
74	negative regulation of heart growth (GO:0061117)	2.76442675
75	vesicle coating (GO:0006901)	2.76226275
76	negative regulation of glucose transport (GO:0010829)	2.73118409
77	positive regulation of gluconeogenesis (GO:0045722)	2.72377788
78	intra-Golgi vesicle-mediated transport (GO:0006891)	2.71065443
79	intestinal cholesterol absorption (GO:0030299)	2.70433042
80	plasma lipoprotein particle assembly (GO:0034377)	2.68604446
81	biotin metabolic process (GO:0006768)	2.66618517
82	fusion of sperm to egg plasma membrane (GO:0007342)	2.65996286
83	oligosaccharide catabolic process (GO:0009313)	2.64818272
84	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)	2.64586287
85	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO	2.64586287
86	regulation of protein activation cascade (GO:2000257)	2.60176562
87	regulation of fibrinolysis (GO:0051917)	2.59419708
88	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.59127682
89	L-phenylalanine catabolic process (GO:0006559)	2.59127682
90	acetyl-CoA metabolic process (GO:0006084)	2.59057630
91	regulation of complement activation (GO:0030449)	2.57650087
92	low-density lipoprotein particle remodeling (GO:0034374)	2.55888372
93	L-glutamate transport (GO:0015813)	2.55888064
94	COPI coating of Golgi vesicle (GO:0048205)	2.55403862
95	Golgi transport vesicle coating (GO:0048200)	2.55403862
96	positive regulation of mRNA 3-end processing (GO:0031442)	2.54594005
97	secondary metabolite biosynthetic process (GO:0044550)	2.54067260
98	regulation of norepinephrine secretion (GO:0014061)	2.52606991
99	regulation of glutamate secretion (GO:0014048)	2.52378891
100	imidazole-containing compound metabolic process (GO:0052803)	2.51117549

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	6.41316431
2	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	4.03666364
3	AR_21572438_ChIP-Seq_LNCaP_Human	3.56766294
4	VDR_22108803_ChIP-Seq_LS180_Human	3.29522254
5	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	3.11762530
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.83784550
7	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.76538797
8	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	2.70527891
9	HIF1A_21447827_ChIP-Seq_MCF-7_Human	2.61388683
10	GATA1_19941826_ChIP-Seq_K562_Human	2.60655486
11	FOXA2_19822575_ChIP-Seq_HepG2_Human	2.55958315
12	RXR_22158963_ChIP-Seq_LIVER_Mouse	2.45356664
13	LXR_22158963_ChIP-Seq_LIVER_Mouse	2.31498904
14	NCOR1_26117541_ChIP-Seq_K562_Human	2.31481510
15	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.24246514
16	GATA2_19941826_ChIP-Seq_K562_Human	2.11428576
17	PPARA_22158963_ChIP-Seq_LIVER_Mouse	2.07902722
18	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.97768323
19	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.97572240
20	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.96109385
21	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.94271906
22	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.91361174
23	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.79855459
24	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.77773069
25	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.76668118
26	GATA1_22025678_ChIP-Seq_K562_Human	1.73611039
27	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.69339452
28	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.66242735
29	FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human	1.55814019
30	SPI1_23127762_ChIP-Seq_K562_Human	1.52914908
31	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.51327473
32	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.50823101
33	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.43697471
34	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	1.43109860
35	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.40338214
36	NKX2-5_21415370_ChIP-Seq_HL-1_Mouse	1.39546059
37	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.37691418
38	LXR_22292898_ChIP-Seq_THP-1_Human	1.34653020
39	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.34468105
40	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.34061533
41	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.32475915
42	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.31461146
43	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.28997572
44	RACK7_27058665_Chip-Seq_MCF-7_Human	1.28920828
45	JUN_21703547_ChIP-Seq_K562_Human	1.27839836
46	P68_20966046_ChIP-Seq_HELA_Human	1.27725361
47	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.26597422
48	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.23658472
49	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.23388690
50	BCOR_27268052_Chip-Seq_Bcells_Human	1.23263943
51	KDM2B_26808549_Chip-Seq_K562_Human	1.21745525
52	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.21500725
53	MAF_26560356_Chip-Seq_TH1_Human	1.21477761
54	MYC_22102868_ChIP-Seq_BL_Human	1.19950471
55	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.19746424
56	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.19349125
57	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.18989195
58	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.17862221
59	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	1.17804651
60	POU5F1_16518401_ChIP-PET_MESCs_Mouse	1.17171760
61	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.15689428
62	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.14959491
63	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.14528498
64	MITF_21258399_ChIP-Seq_MELANOMA_Human	1.14172241
65	SMC4_20622854_ChIP-Seq_HELA_Human	1.13806870
66	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.11732427
67	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	1.11091403
68	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.10697330
69	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.09974347
70	P300_27268052_Chip-Seq_Bcells_Human	1.09837016
71	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.08853595
72	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.08127366
73	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	1.08111480
74	DROSHA_22980978_ChIP-Seq_HELA_Human	1.07580967
75	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.05699397
76	TP53_16413492_ChIP-PET_HCT116_Human	1.05116548
77	CIITA_25753668_ChIP-Seq_RAJI_Human	1.04969818
78	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.02554754
79	TP53_23651856_ChIP-Seq_MEFs_Mouse	1.02307728
80	KDM5A_27292631_Chip-Seq_BREAST_Human	1.01805610
81	CHD1_26751641_Chip-Seq_LNCaP_Human	1.01096067
82	E2F1_20622854_ChIP-Seq_HELA_Human	1.01031553
83	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.00581552
84	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.00035112
85	OCT4_20526341_ChIP-Seq_ESCs_Human	0.99682190
86	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.98425675
87	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.98374101
88	UTX_26944678_Chip-Seq_JUKART_Human	0.98143818
89	CREB1_26743006_Chip-Seq_LNCaP_Human	0.98097331
90	PHF8_20622854_ChIP-Seq_HELA_Human	0.97409172
91	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.94480171
92	GATA6_25053715_ChIP-Seq_YYC3_Human	0.94257223
93	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.93305373
94	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.93094653
95	STAT3_23295773_ChIP-Seq_U87_Human	0.92565929
96	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.92103480
97	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.91791515
98	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.91681782
99	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	0.90231129
100	TFEB_21752829_ChIP-Seq_HELA_Human	0.89202894

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005171_absent_coat_pigmentation	3.90487486
2	MP0004233_abnormal_muscle_weight	3.74031753
3	MP0005408_hypopigmentation	3.60361094
4	MP0003136_yellow_coat_color	3.48803813
5	MP0005083_abnormal_biliary_tract	3.11273250
6	MP0002909_abnormal_adrenal_gland	2.77359702
7	MP0003950_abnormal_plasma_membrane	2.66848721
8	MP0005451_abnormal_body_composition	2.65309062
9	MP0005360_urolithiasis	2.52106281
10	MP0005257_abnormal_intraocular_pressure	2.50741725
11	MP0002139_abnormal_hepatobiliary_system	2.48266621
12	MP0003172_abnormal_lysosome_physiology	2.28272082
13	MP0004264_abnormal_extraembryonic_tissu	2.25483120
14	MP0000372_irregular_coat_pigmentation	2.21061899
15	MP0004185_abnormal_adipocyte_glucose	1.98388023
16	MP0000678_abnormal_parathyroid_gland	1.96156058
17	MP0005167_abnormal_blood-brain_barrier	1.94278045
18	MP0010329_abnormal_lipoprotein_level	1.91532375
19	MP0003011_delayed_dark_adaptation	1.88355858
20	MP0003656_abnormal_erythrocyte_physiolo	1.86007123
21	MP0003959_abnormal_lean_body	1.84802912
22	MP0003045_fibrosis	1.83212792
23	MP0003123_paternal_imprinting	1.76452442
24	MP0004510_myositis	1.74786871
25	MP0005058_abnormal_lysosome_morphology	1.71337000
26	MP0004381_abnormal_hair_follicle	1.68882534
27	MP0000609_abnormal_liver_physiology	1.66533489
28	MP0002009_preneoplasia	1.65868133
29	MP0003646_muscle_fatigue	1.55065582
30	MP0005409_darkened_coat_color	1.54486256
31	MP0003252_abnormal_bile_duct	1.52756366
32	MP0005464_abnormal_platelet_physiology	1.52187811
33	MP0000371_diluted_coat_color	1.49506879
34	MP0003868_abnormal_feces_composition	1.45333956
35	MP0005365_abnormal_bile_salt	1.42465309
36	MP0004019_abnormal_vitamin_homeostasis	1.39292874
37	MP0009697_abnormal_copulation	1.35607689
38	MP0008875_abnormal_xenobiotic_pharmacok	1.34538582
39	MP0003942_abnormal_urinary_system	1.34412510
40	MP0002089_abnormal_postnatal_growth/wei	1.34336584
41	MP0005551_abnormal_eye_electrophysiolog	1.29290460
42	MP0001919_abnormal_reproductive_system	1.28048126
43	MP0009046_muscle_twitch	1.22386088
44	MP0002075_abnormal_coat/hair_pigmentati	1.16933321
45	MP0004742_abnormal_vestibular_system	1.14676104
46	MP0003698_abnormal_male_reproductive	1.08180844
47	MP0002078_abnormal_glucose_homeostasis	1.07438730
48	MP0002166_altered_tumor_susceptibility	1.05642756
49	MP0005085_abnormal_gallbladder_physiolo	1.02240085
50	MP0008961_abnormal_basal_metabolism	1.00954632
51	MP0003953_abnormal_hormone_level	1.00782285
52	MP0001727_abnormal_embryo_implantation	1.00270187
53	MP0001765_abnormal_ion_homeostasis	0.98894818
54	MP0005187_abnormal_penis_morphology	0.98549298
55	MP0003111_abnormal_nucleus_morphology	0.97999184
56	MP0001661_extended_life_span	0.96964765
57	MP0001186_pigmentation_phenotype	0.96633582
58	MP0003879_abnormal_hair_cell	0.94879522
59	MP0004130_abnormal_muscle_cell	0.94744464
60	MP0003638_abnormal_response/metabolism_	0.94426795
61	MP0003122_maternal_imprinting	0.92360568
62	MP0002118_abnormal_lipid_homeostasis	0.91204884
63	MP0010094_abnormal_chromosome_stability	0.88530454
64	MP0002210_abnormal_sex_determination	0.88244544
65	MP0003699_abnormal_female_reproductive	0.87910917
66	MP0005253_abnormal_eye_physiology	0.87516648
67	MP0005636_abnormal_mineral_homeostasis	0.86766669
68	MP0002138_abnormal_hepatobiliary_system	0.86378959
69	MP0005448_abnormal_energy_balance	0.85735561
70	MP0005645_abnormal_hypothalamus_physiol	0.85548294
71	MP0000639_abnormal_adrenal_gland	0.84093611
72	MP0002229_neurodegeneration	0.83978182
73	MP0002095_abnormal_skin_pigmentation	0.83784871
74	MP0002168_other_aberrant_phenotype	0.83042763
75	MP0005220_abnormal_exocrine_pancreas	0.82271677
76	MP0005647_abnormal_sex_gland	0.81687689
77	MP0008569_lethality_at_weaning	0.81631580
78	MP0005389_reproductive_system_phenotype	0.81433234
79	MP0008770_decreased_survivor_rate	0.80579873
80	MP0000598_abnormal_liver_morphology	0.80320857
81	MP0001666_abnormal_nutrient_absorption	0.79713867
82	MP0002269_muscular_atrophy	0.78916013
83	MP0005075_abnormal_melanosome_morpholog	0.78555878
84	MP0001929_abnormal_gametogenesis	0.77813770
85	MP0004134_abnormal_chest_morphology	0.77730596
86	MP0002970_abnormal_white_adipose	0.76431128
87	MP0000653_abnormal_sex_gland	0.75987691
88	MP0001915_intracranial_hemorrhage	0.73666702
89	MP0004142_abnormal_muscle_tone	0.73161236
90	MP0002396_abnormal_hematopoietic_system	0.72994639
91	MP0008007_abnormal_cellular_replicative	0.72893718
92	MP0008775_abnormal_heart_ventricle	0.70488601
93	MP0000015_abnormal_ear_pigmentation	0.70393980
94	MP0005310_abnormal_salivary_gland	0.69809010
95	MP0001145_abnormal_male_reproductive	0.69009580
96	MP0009642_abnormal_blood_homeostasis	0.69008825
97	MP0002877_abnormal_melanocyte_morpholog	0.66807061
98	MP0004085_abnormal_heartbeat	0.64539562
99	MP0002557_abnormal_social/conspecific_i	0.62974325
100	MP0002653_abnormal_ependyma_morphology	0.61418493

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Macroorchidism (HP:0000053)	5.42553004
2	Deep venous thrombosis (HP:0002625)	4.90743609
3	Abnormal gallbladder physiology (HP:0012438)	4.67559143
4	Cholecystitis (HP:0001082)	4.67559143
5	Dysmetric saccades (HP:0000641)	4.40829650
6	Hypobetalipoproteinemia (HP:0003563)	3.94433006
7	Menorrhagia (HP:0000132)	3.76357311
8	Abnormality of glycolysis (HP:0004366)	3.66274650
9	Increased serum pyruvate (HP:0003542)	3.61833671
10	Spontaneous abortion (HP:0005268)	3.57484840
11	Polycythemia (HP:0001901)	3.52709424
12	Hyperthyroidism (HP:0000836)	3.41432545
13	Abnormality of the common coagulation pathway (HP:0010990)	3.39451765
14	Hyperacusis (HP:0010780)	3.12205682
15	Absent/shortened dynein arms (HP:0200106)	3.11778476
16	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.11778476
17	Prolonged partial thromboplastin time (HP:0003645)	3.11576941
18	Reticulocytosis (HP:0001923)	3.05583508
19	Truncus arteriosus (HP:0001660)	3.04541863
20	Urethral obstruction (HP:0000796)	3.03971432
21	Prolonged bleeding time (HP:0003010)	2.94691287
22	Tubulointerstitial nephritis (HP:0001970)	2.89359773
23	Nonimmune hydrops fetalis (HP:0001790)	2.89355255
24	Abnormality of DNA repair (HP:0003254)	2.84256033
25	Peritonitis (HP:0002586)	2.71304743
26	Bowel incontinence (HP:0002607)	2.65949254
27	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.65738374
28	Acanthocytosis (HP:0001927)	2.65517243
29	Heterotopia (HP:0002282)	2.62936466
30	Submucous cleft hard palate (HP:0000176)	2.60003520
31	Impaired pain sensation (HP:0007328)	2.57421737
32	Abnormality of pain sensation (HP:0010832)	2.57421737
33	Abnormal large intestine physiology (HP:0012700)	2.48161425
34	Morphological abnormality of the middle ear (HP:0008609)	2.43836404
35	Genetic anticipation (HP:0003743)	2.42348445
36	Dyschromatopsia (HP:0007641)	2.40866892
37	Sparse lateral eyebrow (HP:0005338)	2.39845546
38	Poikilocytosis (HP:0004447)	2.29149046
39	Hyperphosphatemia (HP:0002905)	2.25996877
40	Abnormality of the fingertips (HP:0001211)	2.24600830
41	Abnormality of the tricuspid valve (HP:0001702)	2.23542852
42	Entropion (HP:0000621)	2.22328096
43	Wide intermamillary distance (HP:0006610)	2.14832494
44	Joint hemorrhage (HP:0005261)	2.14806175
45	Subacute progressive viral hepatitis (HP:0006572)	2.14337134
46	Spinal cord lesions (HP:0100561)	2.10461246
47	Syringomyelia (HP:0003396)	2.10461246
48	Concave nail (HP:0001598)	2.09047110
49	Microvesicular hepatic steatosis (HP:0001414)	2.07945478
50	Abnormality of the aortic arch (HP:0012303)	2.07019027
51	Increased number of teeth (HP:0011069)	2.07008024
52	Cholelithiasis (HP:0001081)	2.06925527
53	Broad palm (HP:0001169)	2.06718928
54	Blue irides (HP:0000635)	2.04964300
55	Abnormal ciliary motility (HP:0012262)	2.02284728
56	Broad face (HP:0000283)	2.01056502
57	Enlarged penis (HP:0000040)	1.99288043
58	Fat malabsorption (HP:0002630)	1.99249693
59	Myocardial infarction (HP:0001658)	1.98942949
60	Seborrheic dermatitis (HP:0001051)	1.96336868
61	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	1.95858363
62	Hypolipoproteinemia (HP:0010981)	1.95026597
63	Xanthomatosis (HP:0000991)	1.94331140
64	Generalized aminoaciduria (HP:0002909)	1.94282193
65	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	1.91857138
66	Menstrual irregularities (HP:0000858)	1.90952559
67	Hyperkalemia (HP:0002153)	1.90037697
68	Attention deficit hyperactivity disorder (HP:0007018)	1.89365763
69	Severe visual impairment (HP:0001141)	1.87521603
70	Spastic paraparesis (HP:0002313)	1.85316999
71	Sensorimotor neuropathy (HP:0007141)	1.84628721
72	Midline defect of the nose (HP:0004122)	1.83691838
73	Disproportionate tall stature (HP:0001519)	1.83577842
74	Renovascular hypertension (HP:0100817)	1.81705591
75	Poikiloderma (HP:0001029)	1.81612963
76	Termporal pattern (HP:0011008)	1.81076127
77	Insidious onset (HP:0003587)	1.81076127
78	Hypercholesterolemia (HP:0003124)	1.78880072
79	Portal hypertension (HP:0001409)	1.76179180
80	Abnormality of reticulocytes (HP:0004312)	1.75870934
81	Underdeveloped nasal alae (HP:0000430)	1.75518202
82	Esophageal varix (HP:0002040)	1.73906225
83	Hypopigmentation of the fundus (HP:0007894)	1.73577971
84	Coarse hair (HP:0002208)	1.73465153
85	Hypergonadotropic hypogonadism (HP:0000815)	1.72751141
86	Hepatocellular carcinoma (HP:0001402)	1.72156041
87	Abnormality of the columella (HP:0009929)	1.70940973
88	Short chin (HP:0000331)	1.70196574
89	Abnormal respiratory motile cilium morphology (HP:0005938)	1.69071795
90	Abnormal respiratory epithelium morphology (HP:0012253)	1.69071795
91	Flat cornea (HP:0007720)	1.68781898
92	Vascular calcification (HP:0004934)	1.68154039
93	Thin bony cortex (HP:0002753)	1.67717410
94	Impaired platelet aggregation (HP:0003540)	1.67668079
95	Abnormal platelet function (HP:0011869)	1.67668079
96	Amelogenesis imperfecta (HP:0000705)	1.67665333
97	Narrow palate (HP:0000189)	1.67330908
98	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	1.66286531
99	Gingival bleeding (HP:0000225)	1.66025458
100	Abnormality of the diencephalon (HP:0010662)	1.65518385

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	3.82627671
2	CDK12	3.79313499
3	ICK	3.12518234
4	SGK3	3.05261370
5	TRIB3	2.88753029
6	IRAK2	2.86198770
7	EEF2K	2.85169654
8	BMPR2	2.57268271
9	SCYL2	2.52287497
10	CAMK1D	2.52257533
11	AKT3	2.40365443
12	CAMK1G	2.38866135
13	PRKCH	2.18105972
14	EIF2AK1	2.00266674
15	CLK1	1.93531109
16	RIPK4	1.81567661
17	FGFR4	1.65931172
18	PDK2	1.63222913
19	NEK9	1.47715576
20	FGFR3	1.45306330
21	SMG1	1.41085792
22	SGK494	1.34461428
23	SGK223	1.34461428
24	CAMKK2	1.32837378
25	WNK4	1.31850334
26	TYRO3	1.29253794
27	MKNK2	1.29071010
28	PRKAA2	1.27393329
29	SGK1	1.23243312
30	MAP3K4	1.22534163
31	MAP2K7	1.22362152
32	NEK1	1.21924524
33	PKN2	1.20105505
34	RIPK1	1.19885843
35	MTOR	1.16798501
36	MAP3K7	1.09324330
37	WNK1	1.06007090
38	SGK2	1.04086348
39	MAPK11	1.02506091
40	SIK1	0.94285959
41	ZAP70	0.93824620
42	MAP3K2	0.91414146
43	GSK3A	0.89397509
44	MAPK15	0.89085622
45	PRKD3	0.86304626
46	BRD4	0.86026037
47	PRKAA1	0.82481989
48	MAP2K4	0.79904083
49	RET	0.73986257
50	MAPKAPK3	0.73772686
51	MAP3K13	0.70415897
52	BTK	0.67329389
53	STK38	0.67294021
54	PDGFRA	0.66917520
55	DDR2	0.65890803
56	MAPKAPK5	0.64200040
57	MAP4K1	0.62458492
58	EPHA3	0.62406229
59	CDK9	0.59395058
60	RPS6KA2	0.57446433
61	RPS6KL1	0.56784569
62	RPS6KC1	0.56784569
63	PRKCB	0.54166366
64	MAPKAPK2	0.52241066
65	ERBB2	0.50616733
66	ERBB4	0.50069055
67	TESK2	0.49876576
68	PDGFRB	0.49610584
69	IRAK3	0.49067720
70	FGFR1	0.48051248
71	MAPK12	0.47631380
72	RPS6KA6	0.47556854
73	TRPM7	0.47067895
74	CDK1	0.45750572
75	BMX	0.45465824
76	NME2	0.44862760
77	RPS6KA3	0.44051684
78	MAPK3	0.42012970
79	EPHB1	0.41278196
80	CDK8	0.41191030
81	CDK7	0.41036550
82	KSR2	0.40880183
83	TNIK	0.40018181
84	LATS2	0.39767723
85	AKT1	0.39707119
86	MAP3K3	0.39333339
87	ATM	0.39329418
88	PDPK1	0.38886615
89	CSNK1E	0.38849440
90	MKNK1	0.38044896
91	CHUK	0.37224185
92	PDK1	0.35355018
93	CSNK1A1	0.35342323
94	NEK6	0.34656463
95	CAMKK1	0.34498939
96	TESK1	0.34339202
97	PRKCG	0.34169248
98	CHEK2	0.33794402
99	SIK2	0.33442223
100	MAPK8	0.33296370

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosaminoglycan degradation_Homo sapiens_hsa00531	5.51915408
2	Steroid biosynthesis_Homo sapiens_hsa00100	2.88900886
3	Other glycan degradation_Homo sapiens_hsa00511	2.78691658
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.75446606
5	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.64017068
6	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.55280605
7	One carbon pool by folate_Homo sapiens_hsa00670	2.54702112
8	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.47025249
9	Butanoate metabolism_Homo sapiens_hsa00650	2.14375292
10	N-Glycan biosynthesis_Homo sapiens_hsa00510	2.05267751
11	Complement and coagulation cascades_Homo sapiens_hsa04610	2.03261647
12	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.82509642
13	Propanoate metabolism_Homo sapiens_hsa00640	1.80951283
14	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.67571968
15	Lysine degradation_Homo sapiens_hsa00310	1.62805957
16	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.59133346
17	ABC transporters_Homo sapiens_hsa02010	1.53335664
18	GABAergic synapse_Homo sapiens_hsa04727	1.50453471
19	Fatty acid metabolism_Homo sapiens_hsa01212	1.49350501
20	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.34331302
21	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.34287082
22	Morphine addiction_Homo sapiens_hsa05032	1.28047615
23	Serotonergic synapse_Homo sapiens_hsa04726	1.22787958
24	Pyruvate metabolism_Homo sapiens_hsa00620	1.22754600
25	Mineral absorption_Homo sapiens_hsa04978	1.15342278
26	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.08185530
27	mTOR signaling pathway_Homo sapiens_hsa04150	1.06111038
28	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.01726100
29	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.00272742
30	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.00093421
31	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.95701562
32	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.95640940
33	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.95620316
34	Bile secretion_Homo sapiens_hsa04976	0.94666837
35	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.93647451
36	Glutamatergic synapse_Homo sapiens_hsa04724	0.93490154
37	Taste transduction_Homo sapiens_hsa04742	0.92159895
38	Nitrogen metabolism_Homo sapiens_hsa00910	0.89650882
39	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.88870534
40	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.88617424
41	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.85264053
42	Non-small cell lung cancer_Homo sapiens_hsa05223	0.85197271
43	Cholinergic synapse_Homo sapiens_hsa04725	0.85193129
44	Pancreatic cancer_Homo sapiens_hsa05212	0.84781220
45	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.84603211
46	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.84413581
47	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.83108749
48	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.82673586
49	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.81933440
50	Choline metabolism in cancer_Homo sapiens_hsa05231	0.80921884
51	Type II diabetes mellitus_Homo sapiens_hsa04930	0.79750553
52	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.76721649
53	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.74554869
54	PPAR signaling pathway_Homo sapiens_hsa03320	0.73511099
55	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.68660819
56	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.68496709
57	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.68407324
58	Nucleotide excision repair_Homo sapiens_hsa03420	0.67705843
59	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.67349921
60	Circadian entrainment_Homo sapiens_hsa04713	0.65428915
61	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.61475174
62	Fatty acid elongation_Homo sapiens_hsa00062	0.60400988
63	VEGF signaling pathway_Homo sapiens_hsa04370	0.59950373
64	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.58851514
65	ErbB signaling pathway_Homo sapiens_hsa04012	0.58615877
66	Linoleic acid metabolism_Homo sapiens_hsa00591	0.57421688
67	Prolactin signaling pathway_Homo sapiens_hsa04917	0.57137719
68	Fat digestion and absorption_Homo sapiens_hsa04975	0.56875824
69	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.56383195
70	Sphingolipid metabolism_Homo sapiens_hsa00600	0.56011514
71	Chemical carcinogenesis_Homo sapiens_hsa05204	0.55371716
72	Insulin signaling pathway_Homo sapiens_hsa04910	0.54857887
73	Endometrial cancer_Homo sapiens_hsa05213	0.49696958
74	Carbon metabolism_Homo sapiens_hsa01200	0.47668992
75	Insulin resistance_Homo sapiens_hsa04931	0.47408384
76	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.47292385
77	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.47193677
78	Platelet activation_Homo sapiens_hsa04611	0.46670136
79	Glutathione metabolism_Homo sapiens_hsa00480	0.44316905
80	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.44125253
81	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.44004723
82	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.43976116
83	Tyrosine metabolism_Homo sapiens_hsa00350	0.43405490
84	Phototransduction_Homo sapiens_hsa04744	0.43354191
85	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.40430569
86	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.39553925
87	Glioma_Homo sapiens_hsa05214	0.39292651
88	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.39217592
89	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.39185223
90	beta-Alanine metabolism_Homo sapiens_hsa00410	0.38803263
91	Ras signaling pathway_Homo sapiens_hsa04014	0.38795439
92	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.38638439
93	Glycerolipid metabolism_Homo sapiens_hsa00561	0.37752803
94	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.37333498
95	Chemokine signaling pathway_Homo sapiens_hsa04062	0.36930700
96	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.36761212
97	Small cell lung cancer_Homo sapiens_hsa05222	0.36753197
98	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.35291088
99	Alcoholism_Homo sapiens_hsa05034	0.33715834
100	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.32847740

SNX18P1Y

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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