ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	nuclear pore complex assembly (GO:0051292)	6.12961309
2	iron ion import (GO:0097286)	5.49895187
3	nuclear pore organization (GO:0006999)	5.10843791
4	potassium ion export (GO:0071435)	5.06141152
5	diterpenoid biosynthetic process (GO:0016102)	4.97419952
6	regulation of histone H3-K27 methylation (GO:0061085)	4.94793671
7	histone H3-K9 demethylation (GO:0033169)	4.87833035
8	acrosome reaction (GO:0007340)	4.86632611
9	nucleosome disassembly (GO:0006337)	4.85811179
10	protein-DNA complex disassembly (GO:0032986)	4.85811179
11	motile cilium assembly (GO:0044458)	4.63796197
12	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	4.52897425
13	binding of sperm to zona pellucida (GO:0007339)	4.50530834
14	regulation of phosphoprotein phosphatase activity (GO:0043666)	4.42985830
15	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	4.39813231
16	pore complex assembly (GO:0046931)	4.32591022
17	synapsis (GO:0007129)	4.31093050
18	male meiosis (GO:0007140)	4.23104918
19	chromosome condensation (GO:0030261)	4.20874509
20	membrane repolarization during action potential (GO:0086011)	4.13345368
21	sperm motility (GO:0030317)	4.12493219
22	regulation of RNA export from nucleus (GO:0046831)	4.11632083
23	positive regulation of catecholamine secretion (GO:0033605)	4.08806463
24	regulation of histone H3-K4 methylation (GO:0051569)	4.05026043
25	retinal metabolic process (GO:0042574)	3.98772597
26	homocysteine metabolic process (GO:0050667)	3.91038542
27	DNA packaging (GO:0006323)	3.89234799
28	cilium or flagellum-dependent cell motility (GO:0001539)	3.86737261
29	spermatid development (GO:0007286)	3.84896267
30	positive regulation of glycolytic process (GO:0045821)	3.84838792
31	definitive hemopoiesis (GO:0060216)	3.82624485
32	terpenoid biosynthetic process (GO:0016114)	3.80237874
33	negative regulation of potassium ion transmembrane transport (GO:1901380)	3.77992651
34	mRNA cleavage (GO:0006379)	3.76523844
35	organic cation transport (GO:0015695)	3.65625938
36	monoubiquitinated protein deubiquitination (GO:0035520)	3.64561665
37	cytoplasmic mRNA processing body assembly (GO:0033962)	3.63385312
38	TOR signaling (GO:0031929)	3.58731905
39	sperm-egg recognition (GO:0035036)	3.57475948
40	regulation of translational fidelity (GO:0006450)	3.52548172
41	negative regulation of fatty acid biosynthetic process (GO:0045717)	3.51979420
42	polyamine biosynthetic process (GO:0006596)	3.50653809
43	regulation of nucleobase-containing compound transport (GO:0032239)	3.48224682
44	histone lysine demethylation (GO:0070076)	3.47758746
45	pre-miRNA processing (GO:0031054)	3.47366113
46	coenzyme catabolic process (GO:0009109)	3.38303584
47	misfolded or incompletely synthesized protein catabolic process (GO:0006515)	3.36329997
48	DNA replication initiation (GO:0006270)	3.35806542
49	dicarboxylic acid biosynthetic process (GO:0043650)	3.35778219
50	face development (GO:0060324)	3.30906649
51	poly(A)+ mRNA export from nucleus (GO:0016973)	3.27904060
52	histone demethylation (GO:0016577)	3.27841585
53	mitotic chromosome condensation (GO:0007076)	3.26640721
54	multicellular organism reproduction (GO:0032504)	3.25949665
55	negative regulation of histone methylation (GO:0031061)	3.24644020
56	import into cell (GO:0098657)	3.22664123
57	mannose metabolic process (GO:0006013)	3.20638226
58	regulation of histone methylation (GO:0031060)	3.18411162
59	positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr	3.11717011
60	regulation of oxidative stress-induced neuron death (GO:1903203)	3.06197325
61	response to vitamin A (GO:0033189)	3.04260054
62	androgen biosynthetic process (GO:0006702)	3.03850508
63	UDP-N-acetylglucosamine metabolic process (GO:0006047)	3.01922121
64	peptidyl-lysine dimethylation (GO:0018027)	3.01069471
65	mitotic nuclear envelope disassembly (GO:0007077)	3.00220145
66	heterochromatin organization (GO:0070828)	2.98459360
67	membrane repolarization (GO:0086009)	2.98421877
68	DNA methylation involved in gamete generation (GO:0043046)	2.98261913
69	chromosome organization involved in meiosis (GO:0070192)	2.98184825
70	glutamine family amino acid catabolic process (GO:0009065)	2.94008317
71	cell-cell recognition (GO:0009988)	2.93619552
72	vitamin A metabolic process (GO:0006776)	2.92827272
73	positive regulation of protein kinase C signaling (GO:0090037)	2.91120069
74	regulation of DNA damage checkpoint (GO:2000001)	2.91074141
75	COPII vesicle coating (GO:0048208)	2.90966054
76	nuclear envelope disassembly (GO:0051081)	2.89734772
77	membrane disassembly (GO:0030397)	2.89734772
78	protein dealkylation (GO:0008214)	2.89364900
79	protein demethylation (GO:0006482)	2.89364900
80	regulation of oxidative phosphorylation (GO:0002082)	2.87554639
81	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	2.85741565
82	histone H3-K36 demethylation (GO:0070544)	2.84278368
83	intra-S DNA damage checkpoint (GO:0031573)	2.79801122
84	reproduction (GO:0000003)	2.77511064
85	microtubule depolymerization (GO:0007019)	2.76502511
86	detection of chemical stimulus involved in sensory perception (GO:0050907)	2.75557803
87	male sex determination (GO:0030238)	2.74806697
88	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	2.74771150
89	coronary vasculature morphogenesis (GO:0060977)	2.73382943
90	DNA conformation change (GO:0071103)	2.72150939
91	DNA unwinding involved in DNA replication (GO:0006268)	2.72009523
92	regulation of ARF GTPase activity (GO:0032312)	2.71151904
93	protein export from nucleus (GO:0006611)	2.70377611
94	DNA replication checkpoint (GO:0000076)	2.68915358
95	regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition	2.66744834
96	DNA synthesis involved in DNA repair (GO:0000731)	2.63169816
97	mitotic sister chromatid segregation (GO:0000070)	2.63110248
98	sister chromatid segregation (GO:0000819)	2.61880629
99	positive regulation of protein import into nucleus, translocation (GO:0033160)	2.61097423
100	carnitine transmembrane transport (GO:1902603)	2.58301489

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	6.07422567
2	AR_21909140_ChIP-Seq_LNCAP_Human	3.97964381
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.83805933
4	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	3.35542133
5	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.31537451
6	ESR1_20079471_ChIP-ChIP_T-47D_Human	3.16171993
7	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.98841052
8	GATA1_19941826_ChIP-Seq_K562_Human	2.89285804
9	AR_21572438_ChIP-Seq_LNCaP_Human	2.88855906
10	GATA1_22025678_ChIP-Seq_K562_Human	2.79931975
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.33699120
12	NCOR1_26117541_ChIP-Seq_K562_Human	2.32828062
13	GATA2_19941826_ChIP-Seq_K562_Human	2.29155704
14	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.11981018
15	VDR_22108803_ChIP-Seq_LS180_Human	2.11570768
16	ZNF263_19887448_ChIP-Seq_K562_Human	2.09869677
17	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.08788014
18	SPI1_23127762_ChIP-Seq_K562_Human	2.01709395
19	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.96735511
20	CHD1_26751641_Chip-Seq_LNCaP_Human	1.95201433
21	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.93400020
22	EZH2_22144423_ChIP-Seq_EOC_Human	1.84218779
23	KDM5A_27292631_Chip-Seq_BREAST_Human	1.83379457
24	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.80931878
25	SCL_19346495_ChIP-Seq_HPC-7_Human	1.78850286
26	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.68287371
27	TBL1_22424771_ChIP-Seq_293T_Human	1.67404110
28	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.65921157
29	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.65267247
30	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.64839985
31	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.62867465
32	SMC4_20622854_ChIP-Seq_HELA_Human	1.58119767
33	CREB1_26743006_Chip-Seq_LNCaP_Human	1.56594517
34	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.56247123
35	ER_23166858_ChIP-Seq_MCF-7_Human	1.54476421
36	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.53085233
37	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.52969858
38	NFYB_21822215_ChIP-Seq_K562_Human	1.52904511
39	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.49545267
40	PHF8_20622853_ChIP-Seq_HELA_Human	1.48254808
41	AHR_22903824_ChIP-Seq_MCF-7_Human	1.47868148
42	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.46222822
43	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.46121009
44	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.46121009
45	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.44814971
46	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.44618102
47	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.41558196
48	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.40762820
49	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.37292959
50	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.36317218
51	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.34470066
52	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.33351260
53	KDM2B_26808549_Chip-Seq_K562_Human	1.32084586
54	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.32076145
55	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.31722804
56	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.31470825
57	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.31416447
58	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.31196795
59	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	1.30562241
60	NFYA_21822215_ChIP-Seq_K562_Human	1.30372495
61	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.30102038
62	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.29939566
63	ETV1_20927104_ChIP-Seq_GIST48_Human	1.29508137
64	ERA_21632823_ChIP-Seq_H3396_Human	1.28510010
65	RAC3_21632823_ChIP-Seq_H3396_Human	1.23945914
66	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.23683885
67	KDM2B_26808549_Chip-Seq_DND41_Human	1.23022155
68	LXR_22292898_ChIP-Seq_THP-1_Human	1.22763542
69	MYC_22102868_ChIP-Seq_BL_Human	1.21193423
70	MAF_26560356_Chip-Seq_TH2_Human	1.20269821
71	RACK7_27058665_Chip-Seq_MCF-7_Human	1.19211525
72	RBPJ_21746931_ChIP-Seq_IB4_Human	1.18054676
73	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.17071616
74	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.16341360
75	GATA6_25053715_ChIP-Seq_YYC3_Human	1.15410072
76	CTCF_27219007_Chip-Seq_Bcells_Human	1.13695499
77	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.12756558
78	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.11107889
79	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.10940512
80	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.07857633
81	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.07769573
82	RXR_22108803_ChIP-Seq_LS180_Human	1.06457811
83	OCT4_20526341_ChIP-Seq_ESCs_Human	1.05635924
84	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.04040725
85	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.03779447
86	P68_20966046_ChIP-Seq_HELA_Human	1.02910113
87	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.02033464
88	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	1.01080646
89	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.97732728
90	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.97574208
91	MYB_26560356_Chip-Seq_TH1_Human	0.97221239
92	PHF8_20622854_ChIP-Seq_HELA_Human	0.96790635
93	WT1_19549856_ChIP-ChIP_CCG9911_Human	0.96712205
94	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	0.96438059
95	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.95270916
96	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.95151376
97	CBP_20019798_ChIP-Seq_JUKART_Human	0.95151376
98	HNF4A_19822575_ChIP-Seq_HepG2_Human	0.94164861
99	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.93401467
100	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.92381174

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	5.56721637
2	MP0003315_abnormal_perineum_morphology	3.41323141
3	MP0005451_abnormal_body_composition	3.03559905
4	MP0009697_abnormal_copulation	3.01468621
5	MP0008057_abnormal_DNA_replication	2.93032528
6	MP0000678_abnormal_parathyroid_gland	2.81989381
7	MP0008995_early_reproductive_senescence	2.77074414
8	MP0003698_abnormal_male_reproductive	2.42794881
9	MP0001929_abnormal_gametogenesis	2.33920430
10	MP0005167_abnormal_blood-brain_barrier	2.22262395
11	MP0002132_abnormal_respiratory_system	2.19270901
12	MP0004233_abnormal_muscle_weight	2.12957823
13	MP0005360_urolithiasis	2.11369359
14	MP0003136_yellow_coat_color	2.08476118
15	MP0002160_abnormal_reproductive_system	2.06634777
16	MP0003718_maternal_effect	1.89245846
17	MP0010094_abnormal_chromosome_stability	1.83196812
18	MP0001661_extended_life_span	1.83130885
19	MP0003656_abnormal_erythrocyte_physiolo	1.77105963
20	MP0003045_fibrosis	1.76158871
21	MP0004084_abnormal_cardiac_muscle	1.74225565
22	MP0004957_abnormal_blastocyst_morpholog	1.72041692
23	MP0003111_abnormal_nucleus_morphology	1.68808649
24	MP0004147_increased_porphyrin_level	1.53092178
25	MP0003077_abnormal_cell_cycle	1.52670660
26	MP0005647_abnormal_sex_gland	1.52389080
27	MP0002249_abnormal_larynx_morphology	1.51616991
28	MP0003806_abnormal_nucleotide_metabolis	1.51485460
29	MP0008058_abnormal_DNA_repair	1.50650298
30	MP0003705_abnormal_hypodermis_morpholog	1.49957580
31	MP0005058_abnormal_lysosome_morphology	1.45773438
32	MP0002161_abnormal_fertility/fecundity	1.45701147
33	MP0008004_abnormal_stomach_pH	1.45417365
34	MP0004036_abnormal_muscle_relaxation	1.44731238
35	MP0002210_abnormal_sex_determination	1.42264823
36	MP0005409_darkened_coat_color	1.41317309
37	MP0005408_hypopigmentation	1.40637245
38	MP0004043_abnormal_pH_regulation	1.31079194
39	MP0003693_abnormal_embryo_hatching	1.30841092
40	MP0005187_abnormal_penis_morphology	1.26120651
41	MP0001145_abnormal_male_reproductive	1.24081723
42	MP0002877_abnormal_melanocyte_morpholog	1.21937264
43	MP0005076_abnormal_cell_differentiation	1.21414040
44	MP0008932_abnormal_embryonic_tissue	1.19029275
45	MP0000537_abnormal_urethra_morphology	1.18994070
46	MP0003385_abnormal_body_wall	1.18895674
47	MP0000653_abnormal_sex_gland	1.14364058
48	MP0008007_abnormal_cellular_replicative	1.08565654
49	MP0004264_abnormal_extraembryonic_tissu	1.07490249
50	MP0001672_abnormal_embryogenesis/_devel	1.06742016
51	MP0005380_embryogenesis_phenotype	1.06742016
52	MP0005083_abnormal_biliary_tract	1.05992537
53	MP0002269_muscular_atrophy	1.05013773
54	MP0002086_abnormal_extraembryonic_tissu	1.03878495
55	MP0004134_abnormal_chest_morphology	1.02748541
56	MP0003984_embryonic_growth_retardation	1.01179734
57	MP0003942_abnormal_urinary_system	1.00928644
58	MP0002735_abnormal_chemical_nociception	1.00660095
59	MP0002088_abnormal_embryonic_growth/wei	0.98182428
60	MP0004145_abnormal_muscle_electrophysio	0.97802466
61	MP0001188_hyperpigmentation	0.96195611
62	MP0002080_prenatal_lethality	0.95992417
63	MP0000749_muscle_degeneration	0.95759646
64	MP0010307_abnormal_tumor_latency	0.95187693
65	MP0005171_absent_coat_pigmentation	0.95017417
66	MP0001730_embryonic_growth_arrest	0.93612711
67	MP0005395_other_phenotype	0.93597639
68	MP0003879_abnormal_hair_cell	0.93095451
69	MP0004197_abnormal_fetal_growth/weight/	0.90145536
70	MP0003646_muscle_fatigue	0.89674244
71	MP0010630_abnormal_cardiac_muscle	0.89289533
72	MP0003890_abnormal_embryonic-extraembry	0.88793152
73	MP0003936_abnormal_reproductive_system	0.88018520
74	MP0001348_abnormal_lacrimal_gland	0.87531365
75	MP0003935_abnormal_craniofacial_develop	0.87320796
76	MP0005397_hematopoietic_system_phenotyp	0.86582464
77	MP0001545_abnormal_hematopoietic_system	0.86582464
78	MP0001664_abnormal_digestion	0.84387910
79	MP0009115_abnormal_fat_cell	0.83715897
80	MP0005636_abnormal_mineral_homeostasis	0.82664091
81	MP0004272_abnormal_basement_membrane	0.82613911
82	MP0003699_abnormal_female_reproductive	0.82025555
83	MP0001697_abnormal_embryo_size	0.81497518
84	MP0005389_reproductive_system_phenotype	0.80165192
85	MP0004085_abnormal_heartbeat	0.78990726
86	MP0010368_abnormal_lymphatic_system	0.78641780
87	MP0003937_abnormal_limbs/digits/tail_de	0.75606189
88	MP0005670_abnormal_white_adipose	0.75216618
89	MP0000747_muscle_weakness	0.74115707
90	MP0008770_decreased_survivor_rate	0.74028301
91	MP0000350_abnormal_cell_proliferation	0.73792692
92	MP0002138_abnormal_hepatobiliary_system	0.72625937
93	MP0008775_abnormal_heart_ventricle	0.72460836
94	MP0005646_abnormal_pituitary_gland	0.71539622
95	MP0003868_abnormal_feces_composition	0.71366426
96	MP0002127_abnormal_cardiovascular_syste	0.66505636
97	MP0003959_abnormal_lean_body	0.65884450
98	MP0002085_abnormal_embryonic_tissue	0.65289890
99	MP0000631_abnormal_neuroendocrine_gland	0.64397552
100	MP0001666_abnormal_nutrient_absorption	0.63569852

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal gallbladder physiology (HP:0012438)	4.66459223
2	Cholecystitis (HP:0001082)	4.66459223
3	Ankyloglossia (HP:0010296)	4.23810407
4	Truncus arteriosus (HP:0001660)	4.19237143
5	Dysmetric saccades (HP:0000641)	4.12590111
6	Reticulocytosis (HP:0001923)	4.01258485
7	Colitis (HP:0002583)	3.65726166
8	Bowel incontinence (HP:0002607)	3.50874601
9	Ileus (HP:0002595)	3.50361986
10	Abnormality of the columella (HP:0009929)	3.47178514
11	Abnormality of cochlea (HP:0000375)	3.41493552
12	Self-mutilation (HP:0000742)	3.28389681
13	Hyperthyroidism (HP:0000836)	3.22690375
14	Abnormal large intestine physiology (HP:0012700)	3.21672874
15	Postural instability (HP:0002172)	3.09842869
16	Abnormality of the fingertips (HP:0001211)	3.05675017
17	Resting tremor (HP:0002322)	3.03996038
18	Hypoplasia of the uterus (HP:0000013)	2.98574745
19	Polycythemia (HP:0001901)	2.97681368
20	Abnormality of the intrinsic pathway (HP:0010989)	2.94785766
21	Nonimmune hydrops fetalis (HP:0001790)	2.85323069
22	Ventricular fibrillation (HP:0001663)	2.84955908
23	Homocystinuria (HP:0002156)	2.84371228
24	Abnormality of homocysteine metabolism (HP:0010919)	2.84371228
25	Chromsome breakage (HP:0040012)	2.83600628
26	Acute myeloid leukemia (HP:0004808)	2.81342581
27	Seborrheic dermatitis (HP:0001051)	2.78810531
28	Abnormality of oral frenula (HP:0000190)	2.76800774
29	Abnormality of reticulocytes (HP:0004312)	2.73920590
30	Gonadal dysgenesis (HP:0000133)	2.68680099
31	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.63132845
32	Clumsiness (HP:0002312)	2.62318442
33	Morphological abnormality of the inner ear (HP:0011390)	2.58464729
34	Cerebellar dysplasia (HP:0007033)	2.56118725
35	Germ cell neoplasia (HP:0100728)	2.52301656
36	Reduced antithrombin III activity (HP:0001976)	2.48299841
37	Abnormal sex determination (HP:0012244)	2.47507046
38	Sex reversal (HP:0012245)	2.47507046
39	Flat cornea (HP:0007720)	2.47018734
40	Atelectasis (HP:0100750)	2.45336642
41	Protruding tongue (HP:0010808)	2.37962598
42	Acanthocytosis (HP:0001927)	2.34695614
43	Hypoparathyroidism (HP:0000829)	2.32416320
44	Poikilocytosis (HP:0004447)	2.30964452
45	Duplicated collecting system (HP:0000081)	2.28216592
46	Abnormally folded helix (HP:0008544)	2.27520061
47	Long eyelashes (HP:0000527)	2.25005402
48	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.23597081
49	Absent/shortened dynein arms (HP:0200106)	2.23597081
50	Centrally nucleated skeletal muscle fibers (HP:0003687)	2.22458679
51	Abnormality of DNA repair (HP:0003254)	2.19765556
52	Birth length less than 3rd percentile (HP:0003561)	2.18991558
53	Capillary hemangiomas (HP:0005306)	2.10749861
54	Progressive cerebellar ataxia (HP:0002073)	2.10577498
55	Infertility (HP:0000789)	2.08811897
56	Gaze-evoked nystagmus (HP:0000640)	2.06445560
57	Cholelithiasis (HP:0001081)	2.04579788
58	Hypoplasia of the pons (HP:0012110)	2.03673005
59	Facial hemangioma (HP:0000329)	2.02672540
60	Sandal gap (HP:0001852)	2.01924461
61	Exercise-induced myalgia (HP:0003738)	2.01781812
62	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	1.96304006
63	Abnormality of the tricuspid valve (HP:0001702)	1.94862153
64	Upper limb muscle weakness (HP:0003484)	1.93571681
65	Peripheral hypomyelination (HP:0007182)	1.92204267
66	Enlarged kidneys (HP:0000105)	1.91767801
67	Hyperbilirubinemia (HP:0002904)	1.91024854
68	Meningioma (HP:0002858)	1.89561906
69	Obsessive-compulsive behavior (HP:0000722)	1.89169197
70	Disproportionate tall stature (HP:0001519)	1.89072777
71	Genetic anticipation (HP:0003743)	1.89014755
72	Abnormality of the renal collecting system (HP:0004742)	1.88715995
73	Abnormal ciliary motility (HP:0012262)	1.86943972
74	Sparse lateral eyebrow (HP:0005338)	1.86639748
75	Acute lymphatic leukemia (HP:0006721)	1.85957071
76	Urethral obstruction (HP:0000796)	1.85948023
77	Submucous cleft hard palate (HP:0000176)	1.83841080
78	Abnormality of the pons (HP:0007361)	1.83388415
79	Deep venous thrombosis (HP:0002625)	1.80138514
80	Thoracic kyphosis (HP:0002942)	1.79523840
81	Cafe-au-lait spot (HP:0000957)	1.79456953
82	Abnormality of the lumbar spine (HP:0100712)	1.78706353
83	Slender long bone (HP:0003100)	1.78439424
84	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.78271376
85	Overfolded helix (HP:0000396)	1.77470155
86	Diaphragmatic weakness (HP:0009113)	1.76469515
87	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.74727846
88	Abnormality of the nasal septum (HP:0000419)	1.73554311
89	Adenoma sebaceum (HP:0009720)	1.72570914
90	Angiofibromas (HP:0010615)	1.72570914
91	Lip pit (HP:0100267)	1.72302349
92	Relative macrocephaly (HP:0004482)	1.70840032
93	Conjunctival hamartoma (HP:0100780)	1.69529355
94	Abnormal gallbladder morphology (HP:0012437)	1.68901333
95	Ureteral duplication (HP:0000073)	1.68318721
96	Stereotypic behavior (HP:0000733)	1.66907333
97	Ectopic kidney (HP:0000086)	1.65866641
98	Hypertensive crisis (HP:0100735)	1.65665967
99	Attention deficit hyperactivity disorder (HP:0007018)	1.65364979
100	Inflammation of the large intestine (HP:0002037)	1.64647123

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	5.87938585
2	EEF2K	4.26761503
3	MARK3	3.61633848
4	CDK12	3.27373082
5	AKT3	3.16357999
6	TRIB3	3.07807583
7	LATS1	2.71402002
8	NEK2	2.53117524
9	ICK	2.35177027
10	KSR2	2.29327792
11	PKN2	2.03693960
12	MAP3K2	1.71805889
13	BRSK2	1.59411001
14	NTRK3	1.58377019
15	MTOR	1.57792822
16	RIPK4	1.57423460
17	LATS2	1.52633417
18	EIF2AK1	1.48300339
19	CLK1	1.46473132
20	CAMK1D	1.42424895
21	WNK1	1.40849900
22	SGK223	1.32514642
23	SGK494	1.32514642
24	TTK	1.32077529
25	FRK	1.31887539
26	PLK4	1.27051709
27	STK38	1.26715384
28	SGK2	1.24855296
29	CAMK1G	1.23007529
30	RAF1	1.20620590
31	ZAK	1.20322894
32	NME2	1.20059585
33	BRD4	1.14021786
34	MAP3K13	1.06817169
35	WEE1	1.05917601
36	PBK	1.03830238
37	RPS6KA5	1.03717723
38	TRPM7	1.03399804
39	CDC42BPA	1.01970469
40	RET	1.00449912
41	MYLK	1.00421252
42	MAP3K1	1.00090729
43	TLK1	0.95859960
44	STK3	0.91046881
45	PRKAA2	0.90960221
46	FGFR3	0.89556714
47	SGK3	0.85972779
48	STK38L	0.85859605
49	RPS6KB2	0.83350832
50	KSR1	0.82231182
51	CDK3	0.82186670
52	MAPKAPK3	0.79826969
53	OBSCN	0.78340040
54	MAPKAPK5	0.76007673
55	CDC7	0.72933691
56	PAK2	0.72211469
57	MAP3K7	0.71870717
58	WNK4	0.70605736
59	FGFR4	0.67898235
60	NME1	0.66660466
61	MAP3K8	0.65541506
62	PRKAA1	0.64921893
63	CHEK1	0.63249521
64	RPS6KB1	0.62712291
65	ATM	0.61358849
66	SGK1	0.61257337
67	MARK2	0.60035632
68	EIF2AK3	0.59307858
69	CDK1	0.57805537
70	PDPK1	0.56158537
71	MAPK15	0.54453006
72	CCNB1	0.54156249
73	ATR	0.52771129
74	CHEK2	0.52411316
75	BTK	0.51573828
76	MAP3K10	0.50269592
77	MAP2K6	0.48272415
78	CDK2	0.47298673
79	BRAF	0.47162632
80	MAP2K1	0.46851019
81	PDK1	0.46410811
82	BMPR2	0.46316730
83	BMX	0.44562728
84	AKT1	0.43595733
85	CDK7	0.42546687
86	GSK3B	0.42479523
87	YES1	0.42412082
88	MAPK10	0.42062841
89	MAPK11	0.41937807
90	TYRO3	0.41210266
91	SIK2	0.40604347
92	SRPK1	0.39159229
93	PRKG2	0.38100624
94	PIK3CG	0.37249895
95	MAP3K9	0.35282307
96	MAPK1	0.35193670
97	NEK6	0.33942464
98	PAK1	0.33923652
99	RPS6KA3	0.33384581
100	CSNK1E	0.32825767

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	3.02295643
2	Olfactory transduction_Homo sapiens_hsa04740	2.79341517
3	Arginine biosynthesis_Homo sapiens_hsa00220	2.39343841
4	One carbon pool by folate_Homo sapiens_hsa00670	2.28643728
5	Butanoate metabolism_Homo sapiens_hsa00650	2.27753746
6	Gap junction_Homo sapiens_hsa04540	2.08891069
7	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.93203925
8	mTOR signaling pathway_Homo sapiens_hsa04150	1.90706144
9	ABC transporters_Homo sapiens_hsa02010	1.88066902
10	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.81815129
11	mRNA surveillance pathway_Homo sapiens_hsa03015	1.77897831
12	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.75963905
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.74041226
14	Pyruvate metabolism_Homo sapiens_hsa00620	1.65282740
15	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.65107944
16	Type II diabetes mellitus_Homo sapiens_hsa04930	1.59587858
17	Nitrogen metabolism_Homo sapiens_hsa00910	1.59164080
18	Propanoate metabolism_Homo sapiens_hsa00640	1.50794598
19	Lysine degradation_Homo sapiens_hsa00310	1.48820016
20	RNA transport_Homo sapiens_hsa03013	1.42674495
21	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.37243345
22	Acute myeloid leukemia_Homo sapiens_hsa05221	1.35642581
23	DNA replication_Homo sapiens_hsa03030	1.26212153
24	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.25583874
25	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.23776379
26	Prostate cancer_Homo sapiens_hsa05215	1.22282153
27	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.17860512
28	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.16716481
29	Non-small cell lung cancer_Homo sapiens_hsa05223	1.16554182
30	VEGF signaling pathway_Homo sapiens_hsa04370	1.14380879
31	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.14043189
32	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.09049874
33	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.08950837
34	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.08172950
35	Apoptosis_Homo sapiens_hsa04210	1.07823996
36	Fanconi anemia pathway_Homo sapiens_hsa03460	1.07266670
37	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.05864344
38	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.05849976
39	Homologous recombination_Homo sapiens_hsa03440	1.05628270
40	ErbB signaling pathway_Homo sapiens_hsa04012	1.04295669
41	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.03988654
42	Cell cycle_Homo sapiens_hsa04110	1.00823537
43	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.00130628
44	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.99789767
45	Insulin signaling pathway_Homo sapiens_hsa04910	0.99687098
46	Oocyte meiosis_Homo sapiens_hsa04114	0.98353689
47	Insulin resistance_Homo sapiens_hsa04931	0.98171525
48	AMPK signaling pathway_Homo sapiens_hsa04152	0.97227721
49	Choline metabolism in cancer_Homo sapiens_hsa05231	0.96673529
50	Fatty acid metabolism_Homo sapiens_hsa01212	0.96066428
51	MicroRNAs in cancer_Homo sapiens_hsa05206	0.94278435
52	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.91805775
53	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.88192523
54	Thyroid cancer_Homo sapiens_hsa05216	0.87043628
55	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.83889418
56	Endometrial cancer_Homo sapiens_hsa05213	0.83651884
57	Glioma_Homo sapiens_hsa05214	0.79448856
58	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.76488446
59	Carbon metabolism_Homo sapiens_hsa01200	0.74549796
60	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.73760527
61	Alcoholism_Homo sapiens_hsa05034	0.72026443
62	Bile secretion_Homo sapiens_hsa04976	0.69932401
63	Phenylalanine metabolism_Homo sapiens_hsa00360	0.69271905
64	Estrogen signaling pathway_Homo sapiens_hsa04915	0.69252400
65	Circadian rhythm_Homo sapiens_hsa04710	0.69125639
66	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.68246826
67	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.67716146
68	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.67312506
69	Adherens junction_Homo sapiens_hsa04520	0.65809641
70	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.65273778
71	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.64576829
72	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.64429974
73	Mismatch repair_Homo sapiens_hsa03430	0.63464911
74	Basal transcription factors_Homo sapiens_hsa03022	0.63353834
75	Retinol metabolism_Homo sapiens_hsa00830	0.62472398
76	Prolactin signaling pathway_Homo sapiens_hsa04917	0.61256677
77	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.59216308
78	Purine metabolism_Homo sapiens_hsa00230	0.58847892
79	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.58623147
80	Arginine and proline metabolism_Homo sapiens_hsa00330	0.58157868
81	Nucleotide excision repair_Homo sapiens_hsa03420	0.58150929
82	Taste transduction_Homo sapiens_hsa04742	0.57340630
83	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.57282054
84	Glucagon signaling pathway_Homo sapiens_hsa04922	0.56997586
85	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.56185044
86	FoxO signaling pathway_Homo sapiens_hsa04068	0.55686399
87	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.55129096
88	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.54883690
89	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.54176352
90	Viral carcinogenesis_Homo sapiens_hsa05203	0.52500163
91	Melanoma_Homo sapiens_hsa05218	0.52223613
92	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.51522757
93	Glutathione metabolism_Homo sapiens_hsa00480	0.49928910
94	beta-Alanine metabolism_Homo sapiens_hsa00410	0.48229177
95	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.46707614
96	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.46576309
97	Tyrosine metabolism_Homo sapiens_hsa00350	0.46193906
98	Long-term potentiation_Homo sapiens_hsa04720	0.45930811
99	Pancreatic cancer_Homo sapiens_hsa05212	0.45748212
100	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.42354889

SNX18P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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