ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	post-embryonic morphogenesis (GO:0009886)	9.56784119
2	very-low-density lipoprotein particle assembly (GO:0034379)	8.52724503
3	intestinal cholesterol absorption (GO:0030299)	7.67845119
4	response to pheromone (GO:0019236)	7.16799323
5	mitochondrial DNA replication (GO:0006264)	6.72465385
6	folic acid-containing compound biosynthetic process (GO:0009396)	6.38710972
7	folic acid metabolic process (GO:0046655)	6.33305125
8	oogenesis (GO:0048477)	6.03238939
9	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	5.79602034
10	mitochondrial DNA metabolic process (GO:0032042)	5.52573050
11	C4-dicarboxylate transport (GO:0015740)	5.39388977
12	short-chain fatty acid metabolic process (GO:0046459)	5.08925720
13	chaperone mediated protein folding requiring cofactor (GO:0051085)	5.06083804
14	regulation of gene silencing by RNA (GO:0060966)	4.96456730
15	regulation of posttranscriptional gene silencing (GO:0060147)	4.96456730
16	regulation of gene silencing by miRNA (GO:0060964)	4.96456730
17	plasma lipoprotein particle assembly (GO:0034377)	4.94753854
18	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	4.91830055
19	cell wall macromolecule catabolic process (GO:0016998)	4.73710743
20	folic acid-containing compound metabolic process (GO:0006760)	4.72646224
21	alpha-linolenic acid metabolic process (GO:0036109)	4.65099979
22	cholesterol efflux (GO:0033344)	4.61896313
23	protein-lipid complex assembly (GO:0065005)	4.52029206
24	mannose metabolic process (GO:0006013)	4.51244282
25	regulation of translational fidelity (GO:0006450)	4.48576110
26	long term synaptic depression (GO:0060292)	4.41988072
27	energy homeostasis (GO:0097009)	4.40570347
28	peptidyl-lysine dimethylation (GO:0018027)	4.25166144
29	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)	4.23756622
30	regulation of rhodopsin mediated signaling pathway (GO:0022400)	4.12290902
31	regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)	4.04081389
32	cell wall macromolecule metabolic process (GO:0044036)	4.00889847
33	pteridine-containing compound biosynthetic process (GO:0042559)	4.00556975
34	positive regulation of CREB transcription factor activity (GO:0032793)	3.95753574
35	plasma lipoprotein particle organization (GO:0071827)	3.93500211
36	synapsis (GO:0007129)	3.89191970
37	mitochondrial genome maintenance (GO:0000002)	3.87215223
38	histone H3-K9 modification (GO:0061647)	3.84494458
39	rhodopsin mediated signaling pathway (GO:0016056)	3.83626551
40	protein-lipid complex subunit organization (GO:0071825)	3.76332441
41	seminiferous tubule development (GO:0072520)	3.74850814
42	pteridine-containing compound metabolic process (GO:0042558)	3.69511349
43	regulation of response to tumor cell (GO:0002834)	3.68678258
44	positive regulation of response to tumor cell (GO:0002836)	3.68678258
45	positive regulation of immune response to tumor cell (GO:0002839)	3.68678258
46	regulation of immune response to tumor cell (GO:0002837)	3.68678258
47	tetrahydrofolate metabolic process (GO:0046653)	3.65670440
48	mechanosensory behavior (GO:0007638)	3.65257913
49	estrogen biosynthetic process (GO:0006703)	3.64567025
50	female gamete generation (GO:0007292)	3.61819184
51	negative regulation of gene silencing (GO:0060969)	3.56283531
52	regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	3.46550735
53	histone H3-K9 methylation (GO:0051567)	3.43868011
54	male meiosis I (GO:0007141)	3.43476648
55	cell-substrate adherens junction assembly (GO:0007045)	3.40414742
56	focal adhesion assembly (GO:0048041)	3.40414742
57	high-density lipoprotein particle remodeling (GO:0034375)	3.27054695
58	intestinal absorption (GO:0050892)	3.24162359
59	progesterone metabolic process (GO:0042448)	3.23925566
60	ethanol oxidation (GO:0006069)	3.22930570
61	biotin metabolic process (GO:0006768)	3.21373415
62	COPII vesicle coating (GO:0048208)	3.15527848
63	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class	3.15320364
64	regulation of RNA export from nucleus (GO:0046831)	3.15200102
65	meiosis I (GO:0007127)	3.12214526
66	positive regulation of cell size (GO:0045793)	3.09856884
67	regulation of translational elongation (GO:0006448)	3.08195294
68	termination of G-protein coupled receptor signaling pathway (GO:0038032)	3.07743918
69	reverse cholesterol transport (GO:0043691)	3.06594137
70	vitamin transmembrane transport (GO:0035461)	3.06353064
71	collecting duct development (GO:0072044)	3.04679443
72	cellular response to zinc ion (GO:0071294)	3.04174158
73	acyl-CoA biosynthetic process (GO:0071616)	3.00304838
74	thioester biosynthetic process (GO:0035384)	3.00304838
75	hemidesmosome assembly (GO:0031581)	2.98058384
76	cell-substrate junction assembly (GO:0007044)	2.96030361
77	glycerophospholipid catabolic process (GO:0046475)	2.93671844
78	regulation of cholesterol biosynthetic process (GO:0045540)	2.91335868
79	alanine transport (GO:0032328)	2.88573635
80	acetyl-CoA metabolic process (GO:0006084)	2.86848325
81	negative regulation of osteoblast proliferation (GO:0033689)	2.86151349
82	antigen processing and presentation of endogenous antigen (GO:0019883)	2.83434292
83	regulation of G0 to G1 transition (GO:0070316)	2.82988919
84	outer ear morphogenesis (GO:0042473)	2.80947614
85	termination of signal transduction (GO:0023021)	2.76449861
86	sterol transport (GO:0015918)	2.75523324
87	cholesterol transport (GO:0030301)	2.75523324
88	DNA integration (GO:0015074)	2.73564154
89	negative regulation of fatty acid metabolic process (GO:0045922)	2.73034121
90	succinate metabolic process (GO:0006105)	2.71399594
91	negative regulation of activin receptor signaling pathway (GO:0032926)	2.70111923
92	negative regulation of meiosis (GO:0045835)	2.69286471
93	regulation of meiosis I (GO:0060631)	2.69025958
94	protein-lipid complex remodeling (GO:0034368)	2.67460815
95	macromolecular complex remodeling (GO:0034367)	2.67460815
96	plasma lipoprotein particle remodeling (GO:0034369)	2.67460815
97	positive thymic T cell selection (GO:0045059)	2.67061624
98	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	2.66373026
99	C21-steroid hormone biosynthetic process (GO:0006700)	2.65565763
100	cell morphogenesis involved in neuron differentiation (GO:0048667)	12.3828405

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	7.86794375
2	VDR_22108803_ChIP-Seq_LS180_Human	4.67482326
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.24159159
4	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.92093330
5	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.89730575
6	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.86668863
7	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.80393299
8	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.31792390
9	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.29250092
10	HIF1A_21447827_ChIP-Seq_MCF-7_Human	2.28265575
11	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.23014577
12	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.17723826
13	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.13596786
14	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.10007198
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.07281214
16	EWS_26573619_Chip-Seq_HEK293_Human	2.06205631
17	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.01553414
18	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.01348492
19	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.94980310
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.92603129
21	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.87444315
22	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.86440589
23	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.83797013
24	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.79662905
25	TAF15_26573619_Chip-Seq_HEK293_Human	1.69947844
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.69911499
27	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.65721400
28	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.65519033
29	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.62453171
30	BCAT_22108803_ChIP-Seq_LS180_Human	1.62033303
31	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.61152519
32	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.60870142
33	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.58330100
34	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.53229442
35	GATA4_25053715_ChIP-Seq_YYC3_Human	1.46690732
36	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.40061761
37	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.38688605
38	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.37956306
39	SMAD1_18555785_Chip-Seq_ESCs_Mouse	1.37785443
40	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.37518633
41	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.36405681
42	SPI1_26923725_Chip-Seq_HPCs_Mouse	1.36213516
43	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.35871842
44	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.30388323
45	RUNX2_22187159_ChIP-Seq_PCA_Human	1.28670985
46	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.28536693
47	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.27670597
48	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.25017992
49	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.24388916
50	OCT4_20526341_ChIP-Seq_ESCs_Human	1.24115604
51	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.21920265
52	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.20072656
53	E2F1_20622854_ChIP-Seq_HELA_Human	1.19344681
54	CIITA_25753668_ChIP-Seq_RAJI_Human	1.18895173
55	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.18052564
56	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.17981611
57	MYC_18940864_ChIP-ChIP_HL60_Human	1.17561971
58	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.16600617
59	CDX2_22108803_ChIP-Seq_LS180_Human	1.15058815
60	RAC3_21632823_ChIP-Seq_H3396_Human	1.14659743
61	VDR_23849224_ChIP-Seq_CD4+_Human	1.11548151
62	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.10108243
63	NANOG_19829295_ChIP-Seq_ESCs_Human	1.08566716
64	SOX2_19829295_ChIP-Seq_ESCs_Human	1.08566716
65	TCF4_23295773_ChIP-Seq_U87_Human	1.06912958
66	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.06323333
67	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.05009461
68	RUNX1_27457419_Chip-Seq_LIVER_Mouse	1.03191807
69	STAT3_23295773_ChIP-Seq_U87_Human	1.02568615
70	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.02410101
71	CBP_20019798_ChIP-Seq_JUKART_Human	1.02410101
72	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.01455381
73	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	1.01008853
74	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.00873678
75	PU1_27457419_Chip-Seq_LIVER_Mouse	1.00780313
76	SPI1_23127762_ChIP-Seq_K562_Human	0.99083126
77	ZFX_18555785_Chip-Seq_ESCs_Mouse	0.98430820
78	AR_21572438_ChIP-Seq_LNCaP_Human	0.97259085
79	P53_22387025_ChIP-Seq_ESCs_Mouse	0.96202865
80	SMAD4_21799915_ChIP-Seq_A2780_Human	0.95797594
81	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.95092806
82	JUN_21703547_ChIP-Seq_K562_Human	0.94701439
83	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.93739753
84	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.92061165
85	RXR_22108803_ChIP-Seq_LS180_Human	0.91722792
86	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.91588293
87	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.91479422
88	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.90946239
89	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.90156644
90	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.90021951
91	DCP1A_22483619_ChIP-Seq_HELA_Human	0.88556861
92	AHR_22903824_ChIP-Seq_MCF-7_Human	0.88390156
93	TP53_16413492_ChIP-PET_HCT116_Human	0.88183639
94	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.87614229
95	AR_25329375_ChIP-Seq_VCAP_Human	0.87548808
96	KDM5A_27292631_Chip-Seq_BREAST_Human	0.86978761
97	ZNF274_21170338_ChIP-Seq_K562_Hela	0.86354409
98	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.84601132
99	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.84508462
100	GF1B_26923725_Chip-Seq_HPCs_Mouse	0.84137100

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006072_abnormal_retinal_apoptosis	5.03756483
2	MP0003806_abnormal_nucleotide_metabolis	5.02209241
3	MP0003136_yellow_coat_color	4.65066577
4	MP0005257_abnormal_intraocular_pressure	4.07059124
5	MP0003011_delayed_dark_adaptation	3.96519510
6	MP0003172_abnormal_lysosome_physiology	3.79624224
7	MP0003646_muscle_fatigue	3.15645580
8	MP0005253_abnormal_eye_physiology	3.05642842
9	MP0002332_abnormal_exercise_endurance	2.91746009
10	MP0002139_abnormal_hepatobiliary_system	2.87864399
11	MP0005171_absent_coat_pigmentation	2.67069773
12	MP0006292_abnormal_olfactory_placode	2.53452704
13	MP0005085_abnormal_gallbladder_physiolo	2.52095403
14	MP0010329_abnormal_lipoprotein_level	2.46441481
15	MP0005551_abnormal_eye_electrophysiolog	2.32780908
16	MP0005365_abnormal_bile_salt	2.27359108
17	MP0002095_abnormal_skin_pigmentation	2.27156125
18	MP0005408_hypopigmentation	2.24010901
19	MP0001666_abnormal_nutrient_absorption	2.21977041
20	MP0001293_anophthalmia	2.04353164
21	MP0003252_abnormal_bile_duct	1.99670658
22	MP0005391_vision/eye_phenotype	1.89392316
23	MP0005360_urolithiasis	1.85561132
24	MP0004043_abnormal_pH_regulation	1.74135465
25	MP0000372_irregular_coat_pigmentation	1.71837893
26	MP0001873_stomach_inflammation	1.71358110
27	MP0003656_abnormal_erythrocyte_physiolo	1.69634938
28	MP0004272_abnormal_basement_membrane	1.64869191
29	MP0004264_abnormal_extraembryonic_tissu	1.62366304
30	MP0002269_muscular_atrophy	1.59224344
31	MP0010094_abnormal_chromosome_stability	1.57184620
32	MP0005266_abnormal_metabolism	1.56310265
33	MP0003950_abnormal_plasma_membrane	1.54150651
34	MP0001790_abnormal_immune_system	1.50969818
35	MP0005387_immune_system_phenotype	1.50969818
36	MP0008995_early_reproductive_senescence	1.42685005
37	MP0000685_abnormal_immune_system	1.29543639
38	MP0001661_extended_life_span	1.27413197
39	MP0002877_abnormal_melanocyte_morpholog	1.21538793
40	MP0002138_abnormal_hepatobiliary_system	1.21366773
41	MP0003890_abnormal_embryonic-extraembry	1.18772773
42	MP0002254_reproductive_system_inflammat	1.16118688
43	MP0002210_abnormal_sex_determination	1.14934594
44	MP0005076_abnormal_cell_differentiation	1.06785093
45	MP0005332_abnormal_amino_acid	1.04615662
46	MP0003195_calcinosis	1.04460028
47	MP0003638_abnormal_response/metabolism_	1.01080201
48	MP0000609_abnormal_liver_physiology	0.98265921
49	MP0005058_abnormal_lysosome_morphology	0.97748036
50	MP0008057_abnormal_DNA_replication	0.96709772
51	MP0002229_neurodegeneration	0.96528798
52	MP0002092_abnormal_eye_morphology	0.93563720
53	MP0000613_abnormal_salivary_gland	0.93026073
54	MP0008875_abnormal_xenobiotic_pharmacok	0.92857094
55	MP0002909_abnormal_adrenal_gland	0.91415527
56	MP0000639_abnormal_adrenal_gland	0.90629269
57	MP0001270_distended_abdomen	0.89217557
58	MP0004036_abnormal_muscle_relaxation	0.88617985
59	MP0000371_diluted_coat_color	0.88368491
60	MP0005671_abnormal_response_to	0.87516906
61	MP0000598_abnormal_liver_morphology	0.86509497
62	MP0006036_abnormal_mitochondrial_physio	0.85605878
63	MP0001929_abnormal_gametogenesis	0.85281075
64	MP0001919_abnormal_reproductive_system	0.83079479
65	MP0005195_abnormal_posterior_eye	0.82751482
66	MP0005670_abnormal_white_adipose	0.82155743
67	MP0001986_abnormal_taste_sensitivity	0.82072428
68	MP0003959_abnormal_lean_body	0.80720154
69	MP0005410_abnormal_fertilization	0.80710268
70	MP0005023_abnormal_wound_healing	0.80131554
71	MP0005379_endocrine/exocrine_gland_phen	0.79328099
72	MP0001299_abnormal_eye_distance/	0.76761934
73	MP0002098_abnormal_vibrissa_morphology	0.75258104
74	MP0000534_abnormal_ureter_morphology	0.74820508
75	MP0005174_abnormal_tail_pigmentation	0.73279007
76	MP0001145_abnormal_male_reproductive	0.73147336
77	MP0003077_abnormal_cell_cycle	0.73027584
78	MP0002796_impaired_skin_barrier	0.72926710
79	MP0003718_maternal_effect	0.68872940
80	MP0000653_abnormal_sex_gland	0.68682365
81	MP0003111_abnormal_nucleus_morphology	0.68484939
82	MP0005389_reproductive_system_phenotype	0.68148713
83	MP0002118_abnormal_lipid_homeostasis	0.68040971
84	MP0004147_increased_porphyrin_level	0.67475441
85	MP0005083_abnormal_biliary_tract	0.67373929
86	MP0005636_abnormal_mineral_homeostasis	0.67184082
87	MP0001835_abnormal_antigen_presentation	0.66958014
88	MP0003698_abnormal_male_reproductive	0.66473668
89	MP0004381_abnormal_hair_follicle	0.63672353
90	MP0001324_abnormal_eye_pigmentation	0.63392795
91	MP0005647_abnormal_sex_gland	0.62765010
92	MP0000427_abnormal_hair_cycle	0.61990512
93	MP0003868_abnormal_feces_composition	0.60936129
94	MP0002876_abnormal_thyroid_physiology	0.57029523
95	MP0005376_homeostasis/metabolism_phenot	0.56880597
96	MP0008004_abnormal_stomach_pH	0.56279433
97	MP0001119_abnormal_female_reproductive	0.55508784
98	MP0004233_abnormal_muscle_weight	0.54148859
99	MP0009046_muscle_twitch	0.51732889
100	MP0009642_abnormal_blood_homeostasis	0.51710278

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	9.29286036
2	Progressive external ophthalmoplegia (HP:0000590)	7.51249958
3	Agammaglobulinemia (HP:0004432)	7.43796658
4	Persistence of primary teeth (HP:0006335)	7.20511248
5	Proximal tubulopathy (HP:0000114)	5.19324719
6	Supernumerary spleens (HP:0009799)	5.12731933
7	Chronic sinusitis (HP:0011109)	4.84529385
8	Tubulointerstitial nephritis (HP:0001970)	4.53448757
9	Recurrent bronchitis (HP:0002837)	4.15005904
10	Prostate neoplasm (HP:0100787)	4.08690627
11	Urethral obstruction (HP:0000796)	3.98586352
12	Glucose intolerance (HP:0000833)	3.78908685
13	Abnormality of the phalanges of the hallux (HP:0010057)	3.62000556
14	Abnormality of the proximal phalanges of the hand (HP:0009834)	3.59304488
15	Tongue fasciculations (HP:0001308)	3.41954420
16	Duplication of thumb phalanx (HP:0009942)	3.36572898
17	Hydroureter (HP:0000072)	3.35296875
18	Increased connective tissue (HP:0009025)	3.22220972
19	Cellulitis (HP:0100658)	3.21060430
20	Hypobetalipoproteinemia (HP:0003563)	3.18877078
21	Muscle fibrillation (HP:0010546)	3.14637737
22	Prolonged partial thromboplastin time (HP:0003645)	3.13596196
23	Recurrent otitis media (HP:0000403)	3.08809105
24	Coronal craniosynostosis (HP:0004440)	3.02547537
25	Abnormal glucose tolerance (HP:0001952)	3.00700337
26	Microvesicular hepatic steatosis (HP:0001414)	2.94157958
27	Recurrent pneumonia (HP:0006532)	2.91954735
28	Protruding tongue (HP:0010808)	2.91260056
29	Bronchomalacia (HP:0002780)	2.89324620
30	Short nail (HP:0001799)	2.85134659
31	Dysphonia (HP:0001618)	2.83683926
32	Pulmonary artery stenosis (HP:0004415)	2.83042132
33	Hypergonadotropic hypogonadism (HP:0000815)	2.81936504
34	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.80905978
35	Oligomenorrhea (HP:0000876)	2.75391905
36	Delayed CNS myelination (HP:0002188)	2.71825603
37	Nausea (HP:0002018)	2.68457381
38	Preauricular pit (HP:0004467)	2.67972404
39	Periauricular skin pits (HP:0100277)	2.67972404
40	Hypokinesia (HP:0002375)	2.57684190
41	Natal tooth (HP:0000695)	2.55067928
42	Flared iliac wings (HP:0002869)	2.52292487
43	Papilloma (HP:0012740)	2.50684922
44	Verrucae (HP:0200043)	2.50684922
45	External ophthalmoplegia (HP:0000544)	2.50089792
46	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.46011990
47	Azoospermia (HP:0000027)	2.45318134
48	Torticollis (HP:0000473)	2.38863540
49	Abnormal sex determination (HP:0012244)	2.31624956
50	Sex reversal (HP:0012245)	2.31624956
51	Renal cortical cysts (HP:0000803)	2.31537148
52	Hyperglycinemia (HP:0002154)	2.29005615
53	Apathy (HP:0000741)	2.27722626
54	Abnormality of saccadic eye movements (HP:0000570)	2.26749221
55	Abnormality of the middle phalanges of the toes (HP:0010183)	2.26236845
56	Premature ovarian failure (HP:0008209)	2.22855825
57	Flat acetabular roof (HP:0003180)	2.22842647
58	Abnormal tarsal ossification (HP:0008369)	2.22592555
59	Sepsis (HP:0100806)	2.20520545
60	Bronchitis (HP:0012387)	2.18242779
61	Thick nail (HP:0001805)	2.18134771
62	Abnormal spermatogenesis (HP:0008669)	2.14336062
63	Deep venous thrombosis (HP:0002625)	2.12840453
64	Short chin (HP:0000331)	2.06800272
65	Osteomyelitis (HP:0002754)	2.06699396
66	Menorrhagia (HP:0000132)	2.04738173
67	Clumsiness (HP:0002312)	2.04111073
68	Abnormal auditory evoked potentials (HP:0006958)	2.00351160
69	Alopecia of scalp (HP:0002293)	1.99768639
70	Diminished motivation (HP:0000745)	1.98776647
71	Arthropathy (HP:0003040)	1.98719644
72	Abnormality of the intrinsic pathway (HP:0010989)	1.98009566
73	Increased intramyocellular lipid droplets (HP:0012240)	1.93036172
74	Dehydration (HP:0001944)	1.90042307
75	Spontaneous abortion (HP:0005268)	1.88382574
76	Nonimmune hydrops fetalis (HP:0001790)	1.86939654
77	Transposition of the great arteries (HP:0001669)	1.86762707
78	Abnormal connection of the cardiac segments (HP:0011545)	1.86762707
79	Abnormal ventriculo-arterial connection (HP:0011563)	1.86762707
80	Abnormality of the prostate (HP:0008775)	1.84742157
81	Abnormality of the diencephalon (HP:0010662)	1.84150389
82	Chronic hepatic failure (HP:0100626)	1.83931908
83	Mask-like facies (HP:0000298)	1.83691751
84	Skin pits (HP:0100276)	1.81694850
85	Abnormality of the epiphyses of the hand (HP:0005924)	1.81371332
86	Postural tremor (HP:0002174)	1.80452075
87	Progressive muscle weakness (HP:0003323)	1.79887574
88	Depressed nasal tip (HP:0000437)	1.79677535
89	Abnormality of carpal bone ossification (HP:0006257)	1.77685255
90	Abnormality involving the epiphyses of the upper limbs (HP:0003839)	1.75160646
91	Skin rash (HP:0000988)	1.74536133
92	Hepatic necrosis (HP:0002605)	1.72375778
93	Back pain (HP:0003418)	1.71341022
94	Cellular immunodeficiency (HP:0005374)	1.70955819
95	Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)	1.70901362
96	Ragged-red muscle fibers (HP:0003200)	1.70242959
97	Abnormal foot bone ossification (HP:0010675)	1.69466716
98	Nonprogressive disorder (HP:0003680)	1.68495564
99	Recurrent lower respiratory tract infections (HP:0002783)	1.64808122
100	Advanced eruption of teeth (HP:0006288)	1.64522032

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	GRK1	5.35305774
2	EIF2AK1	3.14576611
3	ICK	2.25622849
4	MAPKAPK3	2.20514354
5	TESK2	14.2895345
6	MAP3K13	1.98820798
7	SIK3	1.58190591
8	SIK2	1.57545587
9	SIK1	1.53030171
10	EIF2AK3	1.28123143
11	ZAK	1.07986352
12	CCNB1	1.07897431
13	MARK3	1.02344728
14	PDK2	0.85106904
15	WNK4	0.84247572
16	TRPM7	0.83532960
17	FGFR4	0.83231279
18	MST4	0.81453002
19	AKT3	0.80915014
20	ACVR1B	0.80090529
21	TYK2	0.75610389
22	CAMK1D	0.70783377
23	CDK7	0.68681532
24	CLK1	0.66650741
25	ITK	0.64270596
26	MKNK2	0.64162718
27	BMPR2	0.56161359
28	MAPK11	0.55257674
29	RPS6KA4	0.54469442
30	FGFR3	0.52623802
31	CDK8	0.52216620
32	CDK12	0.50971430
33	TYRO3	0.48545132
34	NEK6	0.47385312
35	NEK1	0.46298459
36	SYK	0.45433915
37	PRKD3	0.44802128
38	CAMK2G	0.44100316
39	BRD4	0.42552826
40	CAMK1G	0.42131281
41	SRPK1	0.41703770
42	CAMK2B	0.41280351
43	CAMK2D	0.40929772
44	DAPK1	0.40650053
45	STK16	0.38594542
46	PRKAA2	0.36210890
47	AURKB	0.34667788
48	MKNK1	0.33563386
49	PDGFRA	0.33452624
50	SGK1	0.29229846
51	PLK1	0.28388449
52	TAF1	0.27055927
53	ATM	0.26939527
54	MARK2	0.26889094
55	ERBB4	0.26816041
56	WNK1	0.24675849
57	FGFR2	0.23863670
58	MTOR	0.23484946
59	MAP3K9	0.23034356
60	MAPK7	0.22255853
61	STK10	0.22237683
62	MAP3K8	0.21831360
63	CDK3	0.21297877
64	YES1	0.21026388
65	STK3	0.20506237
66	FGFR1	0.20260111
67	NEK9	0.19638598
68	PRKACG	0.18924539
69	PRKCI	0.18820778
70	RPS6KB2	0.18093856
71	IGF1R	0.18021478
72	PBK	0.18001109
73	PDPK1	0.16980125
74	PDGFRB	0.16687739
75	RPS6KA5	0.16432898
76	SGK223	0.16412899
77	SGK494	0.16412899
78	CSNK2A2	0.16361344
79	EPHA3	0.16117095
80	BRSK2	0.15940419
81	PAK2	0.15758346
82	FYN	0.15045438
83	ARAF	0.14690876
84	PRKCB	0.14155425
85	TTN	0.13280092
86	CDK1	0.12601291
87	PRKDC	0.12455268
88	MAPKAPK2	0.12450528
89	CSNK1E	0.12169536
90	PRKACA	0.11780688
91	PRKACB	0.11739729
92	GSK3A	0.11483220
93	LYN	0.10923746
94	PRKAA1	0.10499048
95	TTK	0.09933184
96	CSNK2A1	0.09403665
97	BMPR1B	0.09313087
98	EPHA2	0.08793713
99	ATR	0.08744535
100	HCK	0.08541757

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	6.00987006
2	One carbon pool by folate_Homo sapiens_hsa00670	4.87379650
3	Steroid biosynthesis_Homo sapiens_hsa00100	3.98030212
4	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.61324477
5	Propanoate metabolism_Homo sapiens_hsa00640	3.50501370
6	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.59523924
7	Other glycan degradation_Homo sapiens_hsa00511	2.42616063
8	ABC transporters_Homo sapiens_hsa02010	2.33066405
9	Complement and coagulation cascades_Homo sapiens_hsa04610	2.10791905
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.06277651
11	Fatty acid elongation_Homo sapiens_hsa00062	2.00089339
12	Nitrogen metabolism_Homo sapiens_hsa00910	1.89200980
13	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.78619434
14	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.67078909
15	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.66416000
16	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.57315104
17	Glutathione metabolism_Homo sapiens_hsa00480	1.53177234
18	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.52043935
19	PPAR signaling pathway_Homo sapiens_hsa03320	1.48358002
20	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.46257922
21	Folate biosynthesis_Homo sapiens_hsa00790	1.45644138
22	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.39476994
23	Retinol metabolism_Homo sapiens_hsa00830	1.37824052
24	Lysine degradation_Homo sapiens_hsa00310	1.37600813
25	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.35891311
26	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.32204716
27	Butanoate metabolism_Homo sapiens_hsa00650	1.27710551
28	Mineral absorption_Homo sapiens_hsa04978	1.27144586
29	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.24550782
30	Chemical carcinogenesis_Homo sapiens_hsa05204	1.21820344
31	Carbon metabolism_Homo sapiens_hsa01200	1.21113347
32	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.20449400
33	Circadian rhythm_Homo sapiens_hsa04710	1.16332245
34	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.15660964
35	Pyruvate metabolism_Homo sapiens_hsa00620	1.13738438
36	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.12084731
37	Primary immunodeficiency_Homo sapiens_hsa05340	1.03049996
38	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.02423235
39	Nucleotide excision repair_Homo sapiens_hsa03420	0.97007286
40	beta-Alanine metabolism_Homo sapiens_hsa00410	0.95534145
41	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.92158633
42	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.84730927
43	Fatty acid metabolism_Homo sapiens_hsa01212	0.83156443
44	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.82636530
45	Olfactory transduction_Homo sapiens_hsa04740	0.81437273
46	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.80144939
47	Linoleic acid metabolism_Homo sapiens_hsa00591	0.80108910
48	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.78051485
49	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.76097710
50	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.69046077
51	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.67302701
52	Bile secretion_Homo sapiens_hsa04976	0.67152015
53	Peroxisome_Homo sapiens_hsa04146	0.64211970
54	Metabolic pathways_Homo sapiens_hsa01100	0.61752221
55	Histidine metabolism_Homo sapiens_hsa00340	0.61470010
56	Protein export_Homo sapiens_hsa03060	0.61390330
57	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.58196243
58	Type I diabetes mellitus_Homo sapiens_hsa04940	0.58193045
59	Antigen processing and presentation_Homo sapiens_hsa04612	0.56806812
60	Tyrosine metabolism_Homo sapiens_hsa00350	0.56385470
61	Purine metabolism_Homo sapiens_hsa00230	0.55957234
62	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.55377778
63	ECM-receptor interaction_Homo sapiens_hsa04512	0.54134788
64	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.52524672
65	African trypanosomiasis_Homo sapiens_hsa05143	0.52419344
66	Glycerolipid metabolism_Homo sapiens_hsa00561	0.51306012
67	Pyrimidine metabolism_Homo sapiens_hsa00240	0.51272002
68	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.49569473
69	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.49064668
70	RNA degradation_Homo sapiens_hsa03018	0.48053878
71	Allograft rejection_Homo sapiens_hsa05330	0.43955794
72	Taste transduction_Homo sapiens_hsa04742	0.41864654
73	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.41568184
74	Glucagon signaling pathway_Homo sapiens_hsa04922	0.41188429
75	p53 signaling pathway_Homo sapiens_hsa04115	0.40783791
76	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.40762082
77	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.40487174
78	Sphingolipid metabolism_Homo sapiens_hsa00600	0.38924615
79	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.38108021
80	Salivary secretion_Homo sapiens_hsa04970	0.30464962
81	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.29811097
82	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.29266978
83	Renin-angiotensin system_Homo sapiens_hsa04614	0.28736461
84	Glutamatergic synapse_Homo sapiens_hsa04724	0.26969547
85	Asthma_Homo sapiens_hsa05310	0.26853011
86	Base excision repair_Homo sapiens_hsa03410	0.26579419
87	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.24949058
88	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.24760684
89	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.23801125
90	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.23794194
91	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.22665238
92	Phenylalanine metabolism_Homo sapiens_hsa00360	0.22621636
93	Lysosome_Homo sapiens_hsa04142	0.22232459
94	Fat digestion and absorption_Homo sapiens_hsa04975	0.22187878
95	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.20951164
96	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.20905657
97	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.18394854
98	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.16816898
99	Basal transcription factors_Homo sapiens_hsa03022	0.16355571
100	Ether lipid metabolism_Homo sapiens_hsa00565	0.15522218

SNX18P25

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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