ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of cell cycle arrest (GO:0071157)	5.83305984
2	melanin biosynthetic process (GO:0042438)	5.57889085
3	cellular response to vitamin (GO:0071295)	5.55281383
4	very-low-density lipoprotein particle assembly (GO:0034379)	5.10823115
5	response to vitamin A (GO:0033189)	5.09323794
6	response to UV-C (GO:0010225)	5.03856116
7	melanin metabolic process (GO:0006582)	4.97399331
8	negative regulation of norepinephrine secretion (GO:0010700)	4.89298203
9	positive regulation of protein export from nucleus (GO:0046827)	4.56215067
10	embryonic camera-type eye development (GO:0031076)	4.48530319
11	response to magnesium ion (GO:0032026)	4.39217090
12	plasma lipoprotein particle assembly (GO:0034377)	4.39173467
13	mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)	4.30035172
14	cellular response to toxic substance (GO:0097237)	4.26952712
15	cell migration involved in heart development (GO:0060973)	4.25614060
16	response to muscle activity (GO:0014850)	4.24051496
17	secondary metabolite biosynthetic process (GO:0044550)	4.22902714
18	cellular response to antibiotic (GO:0071236)	4.09527571
19	negative regulation of fibrinolysis (GO:0051918)	4.00340824
20	protein-lipid complex assembly (GO:0065005)	3.95520633
21	venous blood vessel morphogenesis (GO:0048845)	3.84820522
22	diacylglycerol metabolic process (GO:0046339)	3.81522158
23	mRNA cleavage (GO:0006379)	3.79830722
24	peptidyl-glutamic acid carboxylation (GO:0017187)	3.78124149
25	protein carboxylation (GO:0018214)	3.78124149
26	spliceosomal tri-snRNP complex assembly (GO:0000244)	3.76709761
27	intestinal absorption (GO:0050892)	3.56640570
28	Golgi transport vesicle coating (GO:0048200)	3.51359372
29	COPI coating of Golgi vesicle (GO:0048205)	3.51359372
30	cellular zinc ion homeostasis (GO:0006882)	3.47740283
31	ventricular cardiac muscle cell development (GO:0055015)	3.47677655
32	intestinal cholesterol absorption (GO:0030299)	3.47196626
33	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	3.46747894
34	COPII vesicle coating (GO:0048208)	3.43862841
35	negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)	3.41032507
36	protein retention in ER lumen (GO:0006621)	3.38727084
37	positive regulation of catecholamine secretion (GO:0033605)	3.34552261
38	activation of protein kinase B activity (GO:0032148)	3.32896540
39	positive regulation of DNA-dependent DNA replication (GO:2000105)	3.30128661
40	negative regulation of hydrogen peroxide-induced cell death (GO:1903206)	3.29749522
41	regulation of fibrinolysis (GO:0051917)	3.23610765
42	regulation of hydrogen peroxide-induced cell death (GO:1903205)	3.22991203
43	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	3.21093207
44	receptor recycling (GO:0001881)	3.20088577
45	pinocytosis (GO:0006907)	3.16764207
46	regulation of apoptotic cell clearance (GO:2000425)	3.13573075
47	dicarboxylic acid biosynthetic process (GO:0043650)	3.12915232
48	lung epithelium development (GO:0060428)	3.05985905
49	regulation of oxidative stress-induced neuron death (GO:1903203)	3.05327998
50	negative regulation of response to reactive oxygen species (GO:1901032)	3.02504940
51	paraxial mesoderm development (GO:0048339)	3.01078840
52	regulation of cholesterol homeostasis (GO:2000188)	3.00935948
53	plasma lipoprotein particle organization (GO:0071827)	2.99677020
54	retinal metabolic process (GO:0042574)	2.94601429
55	regulation of norepinephrine secretion (GO:0014061)	2.93774365
56	alpha-linolenic acid metabolic process (GO:0036109)	2.93308860
57	regulation of protein activation cascade (GO:2000257)	2.93127615
58	regulation of complement activation (GO:0030449)	2.90216470
59	hair cell differentiation (GO:0035315)	2.90195262
60	lung morphogenesis (GO:0060425)	2.88976771
61	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	2.88916941
62	negative regulation of lipase activity (GO:0060192)	2.86664222
63	barbed-end actin filament capping (GO:0051016)	2.86335145
64	protein-lipid complex subunit organization (GO:0071825)	2.84320713
65	regulation of phospholipase A2 activity (GO:0032429)	2.83703006
66	genitalia morphogenesis (GO:0035112)	2.81843606
67	low-density lipoprotein particle remodeling (GO:0034374)	2.80657946
68	artery smooth muscle contraction (GO:0014824)	2.80505704
69	tonic smooth muscle contraction (GO:0014820)	2.78499365
70	coenzyme catabolic process (GO:0009109)	2.78293153
71	plasma lipoprotein particle remodeling (GO:0034369)	2.77580866
72	protein-lipid complex remodeling (GO:0034368)	2.77580866
73	macromolecular complex remodeling (GO:0034367)	2.77580866
74	proline biosynthetic process (GO:0006561)	2.76396087
75	positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)	2.73282840
76	smooth muscle cell differentiation (GO:0051145)	2.69345321
77	cholesterol efflux (GO:0033344)	2.68618811
78	cellular response to nutrient (GO:0031670)	2.67793088
79	regulation of cholesterol esterification (GO:0010872)	2.66616994
80	heterochromatin organization (GO:0070828)	2.65670813
81	protein localization to cell surface (GO:0034394)	2.65270261
82	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	2.62414201
83	plasma lipoprotein particle clearance (GO:0034381)	2.59335200
84	regulation of plasminogen activation (GO:0010755)	2.57978614
85	response to follicle-stimulating hormone (GO:0032354)	2.56586829
86	snRNA processing (GO:0016180)	2.55818315
87	proline metabolic process (GO:0006560)	2.54825824
88	regulation of autophagic vacuole assembly (GO:2000785)	2.53139221
89	negative regulation of catecholamine secretion (GO:0033604)	2.51365619
90	TOR signaling (GO:0031929)	2.49916223
91	muscle cell cellular homeostasis (GO:0046716)	2.47755451
92	glutamine family amino acid biosynthetic process (GO:0009084)	2.47631705
93	mitotic G1 DNA damage checkpoint (GO:0031571)	2.47535332
94	blood coagulation, intrinsic pathway (GO:0007597)	2.46448626
95	positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)	2.45634643
96	regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)	2.45378014
97	snRNA metabolic process (GO:0016073)	2.44482722
98	regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)	2.43568247
99	regulation of bile acid biosynthetic process (GO:0070857)	2.39937388
100	glutamate metabolic process (GO:0006536)	2.39631985

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TP63_17297297_ChIP-ChIP_HaCaT_Human	7.45469060
2	ESR1_20079471_ChIP-ChIP_T-47D_Human	4.38999072
3	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	4.36222634
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.22197798
5	ESR1_15608294_ChIP-ChIP_MCF-7_Human	3.79027710
6	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	3.65937636
7	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	3.62248800
8	ZNF263_19887448_ChIP-Seq_K562_Human	3.42536771
9	AR_21909140_ChIP-Seq_LNCAP_Human	2.82172825
10	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	2.70203218
11	CLOCK_20551151_ChIP-Seq_293T_Human	2.65255427
12	RXR_22158963_ChIP-Seq_LIVER_Mouse	2.50345384
13	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.49107635
14	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.42284763
15	AR_21572438_ChIP-Seq_LNCaP_Human	2.40282119
16	FOXA2_19822575_ChIP-Seq_HepG2_Human	2.18604228
17	LXR_22158963_ChIP-Seq_LIVER_Mouse	2.14719733
18	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.11315104
19	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.09328832
20	TP53_22127205_ChIP-Seq_IMR90_Human	1.97179873
21	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.88651160
22	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.87678469
23	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.85876846
24	IGF1R_20145208_ChIP-Seq_DFB_Human	1.81314841
25	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.80053396
26	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.78138307
27	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.76287655
28	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.63034827
29	GATA6_25053715_ChIP-Seq_YYC3_Human	1.61355608
30	CHD1_26751641_Chip-Seq_LNCaP_Human	1.56380140
31	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.50014558
32	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.46032143
33	SALL4_18804426_ChIP-ChIP_XEN_Mouse	1.41323523
34	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.39994368
35	DCP1A_22483619_ChIP-Seq_HELA_Human	1.38796436
36	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.38309783
37	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.36716424
38	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	1.35030037
39	KDM5A_27292631_Chip-Seq_BREAST_Human	1.34374628
40	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.33646152
41	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.32224302
42	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.30610825
43	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.30062539
44	RACK7_27058665_Chip-Seq_MCF-7_Human	1.28663022
45	NKX2-5_21415370_ChIP-Seq_HL-1_Mouse	1.26532473
46	RXR_22108803_ChIP-Seq_LS180_Human	1.26001275
47	TP53_18474530_ChIP-ChIP_U2OS_Human	1.24024814
48	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.23989739
49	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.22353502
50	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.19229343
51	GABP_19822575_ChIP-Seq_HepG2_Human	1.17036180
52	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.16775869
53	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	1.16695723
54	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.16311305
55	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.15110999
56	ATF3_27146783_Chip-Seq_COLON_Human	1.15004674
57	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.14903108
58	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.12628602
59	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.09751261
60	TFEB_21752829_ChIP-Seq_HELA_Human	1.09060798
61	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.09058833
62	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.08846891
63	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	1.08324330
64	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	1.08232316
65	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.07663610
66	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.06084514
67	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.05946289
68	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.03580068
69	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.01829916
70	SMC4_20622854_ChIP-Seq_HELA_Human	1.00436348
71	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.99319678
72	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.98586076
73	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.98062452
74	GATA4_25053715_ChIP-Seq_YYC3_Human	0.97653318
75	P300_27058665_Chip-Seq_ZR-75-30cells_Human	0.97058367
76	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.93911840
77	GATA4_21415370_ChIP-Seq_HL-1_Mouse	0.93220545
78	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.92652860
79	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.90805305
80	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.90577634
81	TP53_16413492_ChIP-PET_HCT116_Human	0.89148439
82	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.88644698
83	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.85842920
84	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.85835360
85	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.85686918
86	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.85619090
87	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.85008545
88	LXR_22292898_ChIP-Seq_THP-1_Human	0.83667720
89	MITF_21258399_ChIP-Seq_MELANOMA_Human	0.83558202
90	FOXM1_23109430_ChIP-Seq_U2OS_Human	0.83502817
91	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.83311464
92	EOMES_21245162_ChIP-Seq_HESCs_Human	0.83069216
93	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.82835428
94	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	0.82199465
95	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.81879840
96	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.81205377
97	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.80980493
98	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	0.80966200
99	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.80355362
100	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	0.79894955

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005451_abnormal_body_composition	5.33987628
2	MP0010030_abnormal_orbit_morphology	3.55651230
3	MP0002102_abnormal_ear_morphology	3.49852385
4	MP0003136_yellow_coat_color	3.22784632
5	MP0003806_abnormal_nucleotide_metabolis	3.19102264
6	MP0009697_abnormal_copulation	2.96085065
7	MP0005360_urolithiasis	2.79610732
8	MP0002089_abnormal_postnatal_growth/wei	2.62961327
9	MP0003172_abnormal_lysosome_physiology	2.53557817
10	MP0005408_hypopigmentation	2.46607813
11	MP0005058_abnormal_lysosome_morphology	2.29135719
12	MP0004272_abnormal_basement_membrane	2.25711043
13	MP0002139_abnormal_hepatobiliary_system	2.18853106
14	MP0009840_abnormal_foam_cell	2.17091897
15	MP0002132_abnormal_respiratory_system	2.16434421
16	MP0001849_ear_inflammation	2.07870534
17	MP0004233_abnormal_muscle_weight	2.03840208
18	MP0000372_irregular_coat_pigmentation	1.99531025
19	MP0005171_absent_coat_pigmentation	1.90687841
20	MP0003878_abnormal_ear_physiology	1.90228935
21	MP0005377_hearing/vestibular/ear_phenot	1.90228935
22	MP0003315_abnormal_perineum_morphology	1.89992171
23	MP0003385_abnormal_body_wall	1.83447051
24	MP0005409_darkened_coat_color	1.81055780
25	MP0001299_abnormal_eye_distance/	1.80472401
26	MP0002269_muscular_atrophy	1.77595205
27	MP0000371_diluted_coat_color	1.74665313
28	MP0003221_abnormal_cardiomyocyte_apopto	1.71573059
29	MP0001661_extended_life_span	1.64087756
30	MP0001666_abnormal_nutrient_absorption	1.61609605
31	MP0000749_muscle_degeneration	1.55015715
32	MP0010368_abnormal_lymphatic_system	1.51837371
33	MP0005248_abnormal_Harderian_gland	1.47445397
34	MP0005257_abnormal_intraocular_pressure	1.45219137
35	MP0003122_maternal_imprinting	1.41427384
36	MP0010329_abnormal_lipoprotein_level	1.34639734
37	MP0003868_abnormal_feces_composition	1.34438051
38	MP0002092_abnormal_eye_morphology	1.32588361
39	MP0003091_abnormal_cell_migration	1.32199684
40	MP0000534_abnormal_ureter_morphology	1.31963610
41	MP0004084_abnormal_cardiac_muscle	1.31432455
42	MP0005075_abnormal_melanosome_morpholog	1.23818087
43	MP0005330_cardiomyopathy	1.23728782
44	MP0001270_distended_abdomen	1.22100916
45	MP0005365_abnormal_bile_salt	1.21617984
46	MP0004381_abnormal_hair_follicle	1.16883894
47	MP0001915_intracranial_hemorrhage	1.15456598
48	MP0000015_abnormal_ear_pigmentation	1.15010703
49	MP0005397_hematopoietic_system_phenotyp	1.14618420
50	MP0001545_abnormal_hematopoietic_system	1.14618420
51	MP0003942_abnormal_urinary_system	1.14271868
52	MP0005197_abnormal_uvea_morphology	1.12740670
53	MP0010234_abnormal_vibrissa_follicle	1.12684473
54	MP0000537_abnormal_urethra_morphology	1.11800292
55	MP0001324_abnormal_eye_pigmentation	1.04059908
56	MP0003755_abnormal_palate_morphology	1.03097735
57	MP0002938_white_spotting	1.00602799
58	MP0002160_abnormal_reproductive_system	0.98827646
59	MP0003656_abnormal_erythrocyte_physiolo	0.98255824
60	MP0006138_congestive_heart_failure	0.95672793
61	MP0004087_abnormal_muscle_fiber	0.91102135
62	MP0002075_abnormal_coat/hair_pigmentati	0.87227662
63	MP0000733_abnormal_muscle_development	0.86463607
64	MP0004264_abnormal_extraembryonic_tissu	0.86222852
65	MP0002127_abnormal_cardiovascular_syste	0.85420103
66	MP0001697_abnormal_embryo_size	0.84798898
67	MP0003123_paternal_imprinting	0.84643053
68	MP0005187_abnormal_penis_morphology	0.83407689
69	MP0003077_abnormal_cell_cycle	0.82962349
70	MP0000759_abnormal_skeletal_muscle	0.81815684
71	MP0003566_abnormal_cell_adhesion	0.81375597
72	MP0010630_abnormal_cardiac_muscle	0.80440669
73	MP0005385_cardiovascular_system_phenoty	0.78297904
74	MP0001544_abnormal_cardiovascular_syste	0.78297904
75	MP0004197_abnormal_fetal_growth/weight/	0.77557963
76	MP0000762_abnormal_tongue_morphology	0.76946463
77	MP0003935_abnormal_craniofacial_develop	0.76238769
78	MP0004036_abnormal_muscle_relaxation	0.76237689
79	MP0001672_abnormal_embryogenesis/_devel	0.75108796
80	MP0005380_embryogenesis_phenotype	0.75108796
81	MP0003567_abnormal_fetal_cardiomyocyte	0.73373981
82	MP0002233_abnormal_nose_morphology	0.73286045
83	MP0004134_abnormal_chest_morphology	0.72029267
84	MP0004133_heterotaxia	0.71690467
85	MP0005076_abnormal_cell_differentiation	0.71247928
86	MP0000678_abnormal_parathyroid_gland	0.70116175
87	MP0002088_abnormal_embryonic_growth/wei	0.69355222
88	MP0003984_embryonic_growth_retardation	0.68886371
89	MP0000566_synostosis	0.66753778
90	MP0002086_abnormal_extraembryonic_tissu	0.66721458
91	MP0005621_abnormal_cell_physiology	0.66700901
92	MP0008438_abnormal_cutaneous_collagen	0.66522563
93	MP0003941_abnormal_skin_development	0.65855933
94	MP0000003_abnormal_adipose_tissue	0.63830581
95	MP0003011_delayed_dark_adaptation	0.62547802
96	MP0005410_abnormal_fertilization	0.61682797
97	MP0005391_vision/eye_phenotype	0.60443305
98	MP0002118_abnormal_lipid_homeostasis	0.59831970
99	MP0000747_muscle_weakness	0.59661503
100	MP0001529_abnormal_vocalization	0.59453865

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Neoplasm of the adrenal cortex (HP:0100641)	6.82824218
2	Deep venous thrombosis (HP:0002625)	5.96617567
3	Hypoplasia of the iris (HP:0007676)	4.42190689
4	Anal stenosis (HP:0002025)	4.09956791
5	Anterior segment dysgenesis (HP:0007700)	4.00816732
6	Neoplasm of the adrenal gland (HP:0100631)	3.94413941
7	Asymmetry of the thorax (HP:0001555)	3.87177044
8	Prolonged partial thromboplastin time (HP:0003645)	3.68363753
9	Iris hypopigmentation (HP:0007730)	3.60863022
10	Small epiphyses (HP:0010585)	3.36574852
11	Flat acetabular roof (HP:0003180)	3.29091808
12	Abnormal tarsal ossification (HP:0008369)	3.20738550
13	Vaginal fistula (HP:0004320)	3.11815837
14	Exercise-induced myalgia (HP:0003738)	3.08007639
15	Melanoma (HP:0002861)	2.99816079
16	Joint hemorrhage (HP:0005261)	2.90408588
17	Spinal cord lesions (HP:0100561)	2.88644567
18	Syringomyelia (HP:0003396)	2.88644567
19	Congenital glaucoma (HP:0001087)	2.88177894
20	Hypobetalipoproteinemia (HP:0003563)	2.75049851
21	Abnormality of carpal bone ossification (HP:0006257)	2.73634413
22	Ocular albinism (HP:0001107)	2.72775581
23	Alacrima (HP:0000522)	2.70878315
24	Thoracic kyphosis (HP:0002942)	2.70856585
25	Hemorrhage of the eye (HP:0011885)	2.70159907
26	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.67762397
27	Abnormality of the anterior chamber (HP:0000593)	2.66780743
28	Abnormality of the lumbar spine (HP:0100712)	2.55070992
29	Scapular winging (HP:0003691)	2.53154976
30	Aortic aneurysm (HP:0004942)	2.50559009
31	Decreased lacrimation (HP:0000633)	2.49386265
32	Abnormality of the columella (HP:0009929)	2.47495251
33	Hyporeflexia of lower limbs (HP:0002600)	2.47419392
34	Megalocornea (HP:0000485)	2.46485558
35	Abnormality of the intrinsic pathway (HP:0010989)	2.45171325
36	Reduced antithrombin III activity (HP:0001976)	2.41169721
37	Capillary hemangiomas (HP:0005306)	2.40050761
38	Abnormality of the thoracic spine (HP:0100711)	2.39102480
39	Hypercholesterolemia (HP:0003124)	2.38956979
40	Rectovaginal fistula (HP:0000143)	2.38544275
41	Rectal fistula (HP:0100590)	2.38544275
42	Cutaneous melanoma (HP:0012056)	2.36904467
43	Centrally nucleated skeletal muscle fibers (HP:0003687)	2.31343466
44	Broad alveolar ridges (HP:0000187)	2.31221111
45	Intestinal fistula (HP:0100819)	2.28173936
46	Partial duplication of thumb phalanx (HP:0009944)	2.24764365
47	Abnormality of the shoulder girdle musculature (HP:0001435)	2.24649908
48	Posterior embryotoxon (HP:0000627)	2.24266404
49	Xanthomatosis (HP:0000991)	2.22902206
50	Abnormality of the line of Schwalbe (HP:0008048)	2.22883970
51	Menorrhagia (HP:0000132)	2.22647616
52	White forelock (HP:0002211)	2.21369937
53	Mitral stenosis (HP:0001718)	2.17980695
54	Abnormality of the common coagulation pathway (HP:0010990)	2.17186635
55	Acanthocytosis (HP:0001927)	2.16260287
56	Abnormal ossification of hand bones (HP:0005921)	2.11862992
57	Abnormality of the pupil (HP:0000615)	2.11415383
58	Fat malabsorption (HP:0002630)	2.11104007
59	Cupped ribs (HP:0000887)	2.10879400
60	Bifid scrotum (HP:0000048)	2.08518941
61	Spinal rigidity (HP:0003306)	2.08118020
62	Patchy hypopigmentation of hair (HP:0011365)	2.07728318
63	Pancreatic islet-cell hyperplasia (HP:0004510)	2.07623933
64	Ulnar bowing (HP:0003031)	2.04510561
65	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.04031766
66	Protrusio acetabuli (HP:0003179)	2.03450169
67	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	2.01726064
68	Back pain (HP:0003418)	2.00950139
69	Abnormal foot bone ossification (HP:0010675)	1.98781535
70	Epidermoid cyst (HP:0200040)	1.96552103
71	Recurrent corneal erosions (HP:0000495)	1.96328363
72	Neck muscle weakness (HP:0000467)	1.95762230
73	Clumsiness (HP:0002312)	1.95005801
74	Abnormality of the acetabulum (HP:0003170)	1.94924444
75	Freckling (HP:0001480)	1.94422288
76	Hypothermia (HP:0002045)	1.91462262
77	Self-mutilation (HP:0000742)	1.91046653
78	Proximal amyotrophy (HP:0007126)	1.89775419
79	Partial duplication of the phalanx of hand (HP:0009999)	1.89774402
80	Intrahepatic cholestasis (HP:0001406)	1.89298917
81	Complement deficiency (HP:0004431)	1.88040046
82	Prominent supraorbital ridges (HP:0000336)	1.86103951
83	Abnormal hand bone ossification (HP:0010660)	1.82843925
84	Reticulocytosis (HP:0001923)	1.81052427
85	Resting tremor (HP:0002322)	1.80316467
86	Epiphyseal dysplasia (HP:0002656)	1.79817408
87	Facial hemangioma (HP:0000329)	1.76768824
88	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.76581530
89	Rimmed vacuoles (HP:0003805)	1.75591147
90	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.72719332
91	Absent epiphyses (HP:0010577)	1.72719332
92	Hypophosphatemic rickets (HP:0004912)	1.71879267
93	Steatorrhea (HP:0002570)	1.69703596
94	Gonadal dysgenesis (HP:0000133)	1.69673647
95	Skin nodule (HP:0200036)	1.67784193
96	Ankyloglossia (HP:0010296)	1.67643997
97	Abnormality of the pancreatic islet cells (HP:0006476)	1.66997292
98	Abnormality of endocrine pancreas physiology (HP:0012093)	1.66997292
99	Hepatocellular carcinoma (HP:0001402)	1.66165938
100	Poikiloderma (HP:0001029)	1.64828811

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	5.48223083
2	LATS1	4.53216886
3	FGFR4	3.34074956
4	ICK	3.19293035
5	LATS2	2.78100982
6	EEF2K	2.67058746
7	MARK3	2.62366950
8	DAPK3	2.57519828
9	TYRO3	2.50107096
10	TRIB3	2.34462649
11	NEK2	2.32984704
12	RPS6KB1	2.20740995
13	WEE1	2.06015316
14	FGFR3	2.01422349
15	OBSCN	1.88495140
16	CDK12	1.84974480
17	STK38L	1.73355008
18	FGFR2	1.70062283
19	WNK4	1.68828966
20	PDGFRA	1.60295195
21	NME2	1.39652773
22	BMPR2	1.38825201
23	PIM1	1.38047373
24	EIF2AK3	1.33900585
25	EIF2AK1	1.32550200
26	MOS	1.28185734
27	STK38	1.26505772
28	AKT2	1.25022990
29	MYLK	1.21824547
30	CSNK1A1L	1.20741856
31	ERBB4	1.16655183
32	CDK3	1.15239406
33	CDK7	1.12016343
34	MAPKAPK2	1.10647966
35	PKN2	1.10466740
36	AKT3	1.07580703
37	CSNK1G1	1.06284444
38	TGFBR2	1.03735742
39	MAP2K7	1.02989486
40	MAP3K1	1.02611787
41	RET	1.01991932
42	MST1R	0.99139341
43	MAPKAPK3	0.95927544
44	NEK9	0.90752268
45	IRAK3	0.88434710
46	CSNK1G3	0.87516588
47	ERN1	0.87455719
48	MTOR	0.82542929
49	MAP3K2	0.80315198
50	PAK2	0.80165249
51	SGK223	0.80137508
52	SGK494	0.80137508
53	KSR2	0.78296018
54	ERBB3	0.72798036
55	PLK1	0.70795161
56	MAP3K10	0.68789932
57	CSNK1D	0.67456131
58	EPHA2	0.66073647
59	CDC42BPA	0.65256758
60	EPHB1	0.63787126
61	STK39	0.63238329
62	MAP3K13	0.62981987
63	CDK8	0.62756206
64	MET	0.61015224
65	ATM	0.58787284
66	NTRK1	0.57733991
67	PRKG2	0.57472238
68	EPHA3	0.57172549
69	PRKD3	0.56210978
70	FGFR1	0.49789325
71	PTK6	0.48384766
72	SIK1	0.47294439
73	BCR	0.46406298
74	PAK4	0.46389237
75	CSNK1G2	0.45891644
76	PTK2	0.44837240
77	CCNB1	0.44400932
78	RPS6KB2	0.44105694
79	PDPK1	0.42680081
80	ATR	0.41761456
81	ARAF	0.40418592
82	DDR2	0.40249261
83	SGK3	0.39434882
84	CLK1	0.38413623
85	MAPK11	0.36488977
86	MELK	0.36178124
87	PRKAA1	0.34047420
88	KSR1	0.32938401
89	PDGFRB	0.32512494
90	CDK14	0.31992306
91	WNK1	0.31294883
92	RIPK1	0.30486890
93	MAP3K5	0.30162560
94	PIK3CA	0.30044259
95	AKT1	0.29718995
96	SGK2	0.28709312
97	PRKAA2	0.27037636
98	BMPR1B	0.26058145
99	CSNK1A1	0.25975731
100	CDK1	0.25813713

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Complement and coagulation cascades_Homo sapiens_hsa04610	2.52476309
2	Steroid biosynthesis_Homo sapiens_hsa00100	2.41984424
3	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.18765144
4	Bladder cancer_Homo sapiens_hsa05219	2.16447213
5	Tyrosine metabolism_Homo sapiens_hsa00350	2.13346278
6	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.05458896
7	Other glycan degradation_Homo sapiens_hsa00511	1.92116025
8	Arginine biosynthesis_Homo sapiens_hsa00220	1.78992576
9	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.73092061
10	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.72754582
11	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.69771893
12	PPAR signaling pathway_Homo sapiens_hsa03320	1.67482423
13	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.60207659
14	Pyruvate metabolism_Homo sapiens_hsa00620	1.58891401
15	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.58665834
16	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.54898903
17	p53 signaling pathway_Homo sapiens_hsa04115	1.51755604
18	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.49164345
19	Prostate cancer_Homo sapiens_hsa05215	1.48512625
20	Glioma_Homo sapiens_hsa05214	1.44747789
21	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.43800135
22	Phenylalanine metabolism_Homo sapiens_hsa00360	1.43527844
23	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.37834382
24	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.34412798
25	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.33917609
26	Arginine and proline metabolism_Homo sapiens_hsa00330	1.33600143
27	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.32076610
28	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.31261060
29	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.26881460
30	Melanoma_Homo sapiens_hsa05218	1.23190951
31	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.23118534
32	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.20558672
33	Fatty acid metabolism_Homo sapiens_hsa01212	1.19979447
34	Butanoate metabolism_Homo sapiens_hsa00650	1.18917603
35	Fatty acid degradation_Homo sapiens_hsa00071	1.16358062
36	Histidine metabolism_Homo sapiens_hsa00340	1.16124806
37	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.15925862
38	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.15791852
39	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.12816327
40	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.11966987
41	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.11925974
42	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.11364963
43	Lysine degradation_Homo sapiens_hsa00310	1.08151587
44	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.06997228
45	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.01580120
46	Fat digestion and absorption_Homo sapiens_hsa04975	1.00876401
47	mTOR signaling pathway_Homo sapiens_hsa04150	0.99906626
48	Sulfur relay system_Homo sapiens_hsa04122	0.96684968
49	Prion diseases_Homo sapiens_hsa05020	0.92729769
50	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.92545112
51	FoxO signaling pathway_Homo sapiens_hsa04068	0.92321256
52	Endometrial cancer_Homo sapiens_hsa05213	0.90206273
53	Carbon metabolism_Homo sapiens_hsa01200	0.89914040
54	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.89234103
55	Peroxisome_Homo sapiens_hsa04146	0.89030800
56	Thyroid cancer_Homo sapiens_hsa05216	0.88653664
57	Galactose metabolism_Homo sapiens_hsa00052	0.85753565
58	AMPK signaling pathway_Homo sapiens_hsa04152	0.84844550
59	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.84397436
60	beta-Alanine metabolism_Homo sapiens_hsa00410	0.83330160
61	Non-small cell lung cancer_Homo sapiens_hsa05223	0.82486937
62	Insulin signaling pathway_Homo sapiens_hsa04910	0.82318251
63	Propanoate metabolism_Homo sapiens_hsa00640	0.82301905
64	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.79617483
65	Nitrogen metabolism_Homo sapiens_hsa00910	0.79604216
66	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.79276206
67	One carbon pool by folate_Homo sapiens_hsa00670	0.78891971
68	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.78731234
69	Glutathione metabolism_Homo sapiens_hsa00480	0.77321108
70	Adherens junction_Homo sapiens_hsa04520	0.77175706
71	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.76685938
72	MicroRNAs in cancer_Homo sapiens_hsa05206	0.76031882
73	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.73936598
74	ECM-receptor interaction_Homo sapiens_hsa04512	0.71823473
75	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.70217886
76	Small cell lung cancer_Homo sapiens_hsa05222	0.68883636
77	Chemical carcinogenesis_Homo sapiens_hsa05204	0.68280753
78	Focal adhesion_Homo sapiens_hsa04510	0.65924019
79	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.63758650
80	ABC transporters_Homo sapiens_hsa02010	0.63751258
81	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.63129867
82	Bile secretion_Homo sapiens_hsa04976	0.62685976
83	Proteoglycans in cancer_Homo sapiens_hsa05205	0.62077792
84	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.59927882
85	Vibrio cholerae infection_Homo sapiens_hsa05110	0.58175413
86	Glucagon signaling pathway_Homo sapiens_hsa04922	0.56203270
87	Cell cycle_Homo sapiens_hsa04110	0.55229571
88	Insulin resistance_Homo sapiens_hsa04931	0.55053498
89	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.54624076
90	mRNA surveillance pathway_Homo sapiens_hsa03015	0.54391453
91	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.53312455
92	Circadian rhythm_Homo sapiens_hsa04710	0.52972829
93	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.52069063
94	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.49849163
95	Sphingolipid metabolism_Homo sapiens_hsa00600	0.49800311
96	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.49579118
97	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.49392904
98	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.48774721
99	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.48083439
100	Gap junction_Homo sapiens_hsa04540	0.47089795

SNX18P26

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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