ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	nuclear pore complex assembly (GO:0051292)	4.72489386
2	monoubiquitinated protein deubiquitination (GO:0035520)	4.70119882
3	regulation of hippo signaling (GO:0035330)	4.68065799
4	regulation of posttranscriptional gene silencing (GO:0060147)	4.32434909
5	regulation of gene silencing by miRNA (GO:0060964)	4.32434909
6	regulation of gene silencing by RNA (GO:0060966)	4.32434909
7	nuclear pore organization (GO:0006999)	4.11513379
8	pre-miRNA processing (GO:0031054)	3.81274362
9	mRNA cleavage (GO:0006379)	3.65899641
10	very-low-density lipoprotein particle assembly (GO:0034379)	3.64445121
11	sex differentiation (GO:0007548)	3.56754786
12	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.49370974
13	regulation of translation, ncRNA-mediated (GO:0045974)	3.49370974
14	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.49370974
15	cilium or flagellum-dependent cell motility (GO:0001539)	3.44069799
16	negative regulation of protein activation cascade (GO:2000258)	3.43233040
17	protein K48-linked deubiquitination (GO:0071108)	3.38513386
18	regulation of centrosome duplication (GO:0010824)	3.31711359
19	positive regulation of developmental pigmentation (GO:0048087)	3.24868452
20	cytoplasmic mRNA processing body assembly (GO:0033962)	3.24713598
21	interkinetic nuclear migration (GO:0022027)	3.23205563
22	pore complex assembly (GO:0046931)	3.22483186
23	UDP-N-acetylglucosamine metabolic process (GO:0006047)	3.22269698
24	tryptophan catabolic process (GO:0006569)	3.21276721
25	indole-containing compound catabolic process (GO:0042436)	3.21276721
26	indolalkylamine catabolic process (GO:0046218)	3.21276721
27	regulation of centriole replication (GO:0046599)	3.19295507
28	intestinal cholesterol absorption (GO:0030299)	3.17406165
29	plasma lipoprotein particle assembly (GO:0034377)	3.17142568
30	negative regulation of complement activation (GO:0045916)	3.15699970
31	low-density lipoprotein particle remodeling (GO:0034374)	3.08090667
32	dicarboxylic acid biosynthetic process (GO:0043650)	3.07509282
33	negative regulation of sodium ion transport (GO:0010766)	3.07010716
34	mitotic sister chromatid cohesion (GO:0007064)	3.06148160
35	regulation of establishment of cell polarity (GO:2000114)	3.04330348
36	regulation of protein activation cascade (GO:2000257)	3.03486658
37	regulation of complement activation (GO:0030449)	3.03393536
38	motile cilium assembly (GO:0044458)	2.98792799
39	receptor recycling (GO:0001881)	2.94876655
40	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	2.94422609
41	gene silencing by RNA (GO:0031047)	2.92293683
42	regulation of centrosome cycle (GO:0046605)	2.91461509
43	protein prenylation (GO:0018342)	2.91346909
44	prenylation (GO:0097354)	2.91346909
45	indolalkylamine metabolic process (GO:0006586)	2.85470228
46	acrosome assembly (GO:0001675)	2.81665391
47	inner cell mass cell proliferation (GO:0001833)	2.79542799
48	negative regulation of fibrinolysis (GO:0051918)	2.75452978
49	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.75388414
50	kynurenine metabolic process (GO:0070189)	2.73668444
51	regulation of DNA endoreduplication (GO:0032875)	2.70111506
52	positive regulation of cell cycle checkpoint (GO:1901978)	2.70034270
53	centrosome duplication (GO:0051298)	2.69365529
54	sister chromatid segregation (GO:0000819)	2.66957764
55	regulation of RNA export from nucleus (GO:0046831)	2.66023345
56	histone H3-K9 methylation (GO:0051567)	2.64329154
57	protein-lipid complex assembly (GO:0065005)	2.63485734
58	one-carbon compound transport (GO:0019755)	2.63171667
59	regulation of establishment or maintenance of cell polarity (GO:0032878)	2.63036038
60	TOR signaling (GO:0031929)	2.62946347
61	DNA synthesis involved in DNA repair (GO:0000731)	2.61726694
62	DNA replication initiation (GO:0006270)	2.61598929
63	tryptophan metabolic process (GO:0006568)	2.60191253
64	cellular response to sterol (GO:0036315)	2.60003872
65	DNA geometric change (GO:0032392)	2.59738128
66	notochord development (GO:0030903)	2.58288767
67	heterochromatin organization (GO:0070828)	2.56830492
68	positive regulation of transcription from RNA polymerase III promoter (GO:0045945)	2.54566248
69	DNA duplex unwinding (GO:0032508)	2.53185958
70	mitotic G2/M transition checkpoint (GO:0044818)	2.52446490
71	embryonic retina morphogenesis in camera-type eye (GO:0060059)	2.51420195
72	aromatic amino acid family catabolic process (GO:0009074)	2.50784693
73	nephron epithelium morphogenesis (GO:0072088)	2.50072267
74	nephron tubule morphogenesis (GO:0072078)	2.50072267
75	peptidyl-threonine dephosphorylation (GO:0035970)	2.48975948
76	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.47653060
77	double-strand break repair via nonhomologous end joining (GO:0006303)	2.44000631
78	non-recombinational repair (GO:0000726)	2.44000631
79	protein K11-linked deubiquitination (GO:0035871)	2.42573881
80	positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)	2.42259928
81	positive regulation of cell cycle G2/M phase transition (GO:1902751)	2.42259928
82	sister chromatid cohesion (GO:0007062)	2.42083450
83	centriole assembly (GO:0098534)	2.37911891
84	regulation of pigment cell differentiation (GO:0050932)	2.37307388
85	regulation of gene silencing (GO:0060968)	2.35900625
86	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.34261210
87	protein-lipid complex remodeling (GO:0034368)	2.34144325
88	macromolecular complex remodeling (GO:0034367)	2.34144325
89	plasma lipoprotein particle remodeling (GO:0034369)	2.34144325
90	plasma lipoprotein particle organization (GO:0071827)	2.33939724
91	regulation of apoptotic cell clearance (GO:2000425)	2.33696021
92	microtubule anchoring (GO:0034453)	2.31907972
93	amino-acid betaine transport (GO:0015838)	2.31432272
94	carnitine transport (GO:0015879)	2.31432272
95	microtubule organizing center organization (GO:0031023)	2.30666937
96	carnitine transmembrane transport (GO:1902603)	2.27522379
97	aromatic amino acid family metabolic process (GO:0009072)	2.26775701
98	double-strand break repair via homologous recombination (GO:0000724)	2.25930258
99	mitotic sister chromatid segregation (GO:0000070)	2.25674010
100	quaternary ammonium group transport (GO:0015697)	2.25307963

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	5.89441662
2	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	3.80634161
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.40417245
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.15266023
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.98137326
6	VDR_22108803_ChIP-Seq_LS180_Human	2.90926757
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.61101542
8	AR_21572438_ChIP-Seq_LNCaP_Human	2.59822380
9	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.53920251
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.44259174
11	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.39753506
12	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.34691886
13	AR_21909140_ChIP-Seq_LNCAP_Human	2.34557432
14	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.27008876
15	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.26848571
16	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.24668473
17	FOXA2_19822575_ChIP-Seq_HepG2_Human	2.13228397
18	TAF15_26573619_Chip-Seq_HEK293_Human	2.09049857
19	TP53_16413492_ChIP-PET_HCT116_Human	2.08071065
20	STAT3_23295773_ChIP-Seq_U87_Human	2.07900908
21	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.07339379
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.07278031
23	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.03331409
24	FUS_26573619_Chip-Seq_HEK293_Human	2.00407509
25	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.87956345
26	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.87914747
27	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.87640433
28	EWS_26573619_Chip-Seq_HEK293_Human	1.86342320
29	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.83685983
30	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.76972755
31	SMAD4_21799915_ChIP-Seq_A2780_Human	1.72800875
32	ER_23166858_ChIP-Seq_MCF-7_Human	1.70064743
33	TCF4_23295773_ChIP-Seq_U87_Human	1.69695948
34	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.69382173
35	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.68152651
36	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.67571160
37	P300_19829295_ChIP-Seq_ESCs_Human	1.63571102
38	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.61820680
39	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.58208087
40	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.54472599
41	FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human	1.51169734
42	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.46952104
43	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.46717543
44	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.46717543
45	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.44385857
46	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.43729579
47	AHR_22903824_ChIP-Seq_MCF-7_Human	1.42145983
48	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.39188792
49	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.37266734
50	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.36816670
51	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.35584581
52	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.34596650
53	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.33581375
54	GATA1_22025678_ChIP-Seq_K562_Human	1.33237662
55	CBP_20019798_ChIP-Seq_JUKART_Human	1.31828295
56	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.31828295
57	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.30555520
58	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.28696958
59	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.27897814
60	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.27152706
61	BCAT_22108803_ChIP-Seq_LS180_Human	1.25315365
62	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.22667499
63	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.22576974
64	RUNX2_22187159_ChIP-Seq_PCA_Human	1.21980495
65	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.21815244
66	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.19780749
67	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.19494214
68	TCF4_22108803_ChIP-Seq_LS180_Human	1.19264572
69	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.19036390
70	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.16406239
71	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.14932579
72	CDX2_22108803_ChIP-Seq_LS180_Human	1.14432893
73	RXR_22108803_ChIP-Seq_LS180_Human	1.11840482
74	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.11656027
75	SALL4_18804426_ChIP-ChIP_XEN_Mouse	1.08341958
76	GATA4_25053715_ChIP-Seq_YYC3_Human	1.07774330
77	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.07539035
78	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.07324627
79	TP53_18474530_ChIP-ChIP_U2OS_Human	1.06960845
80	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.06330090
81	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.05190872
82	SOX9_26525672_Chip-Seq_HEART_Mouse	1.05081103
83	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.03350585
84	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.03011050
85	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.02546905
86	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.02461115
87	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.01277559
88	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.98921913
89	YAP1_20516196_ChIP-Seq_MESCs_Mouse	0.98436469
90	AR_25329375_ChIP-Seq_VCAP_Human	0.98025535
91	DROSHA_22980978_ChIP-Seq_HELA_Human	0.97963418
92	AR_19668381_ChIP-Seq_PC3_Human	0.96422811
93	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.95957150
94	GATA6_25053715_ChIP-Seq_YYC3_Human	0.94388014
95	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.94292223
96	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.94101105
97	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.93226244
98	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.92886975
99	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.92340446
100	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.92151557

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008057_abnormal_DNA_replication	5.04026667
2	MP0003136_yellow_coat_color	3.04011422
3	MP0009697_abnormal_copulation	2.91464698
4	MP0010094_abnormal_chromosome_stability	2.44679849
5	MP0003950_abnormal_plasma_membrane	2.44548505
6	MP0000569_abnormal_digit_pigmentation	2.42903971
7	MP0005408_hypopigmentation	2.42893901
8	MP0003195_calcinosis	2.29388615
9	MP0002938_white_spotting	1.96641319
10	MP0008058_abnormal_DNA_repair	1.86027002
11	MP0003111_abnormal_nucleus_morphology	1.83866634
12	MP0001661_extended_life_span	1.77678322
13	MP0001666_abnormal_nutrient_absorption	1.70201873
14	MP0003941_abnormal_skin_development	1.69776946
15	MP0003890_abnormal_embryonic-extraembry	1.66143336
16	MP0003868_abnormal_feces_composition	1.64075996
17	MP0004233_abnormal_muscle_weight	1.62340579
18	MP0003123_paternal_imprinting	1.60957281
19	MP0003646_muscle_fatigue	1.51599518
20	MP0003718_maternal_effect	1.51433199
21	MP0003122_maternal_imprinting	1.50948066
22	MP0000383_abnormal_hair_follicle	1.46088728
23	MP0003943_abnormal_hepatobiliary_system	1.45183509
24	MP0005360_urolithiasis	1.43844697
25	MP0003252_abnormal_bile_duct	1.43545278
26	MP0003937_abnormal_limbs/digits/tail_de	1.39655690
27	MP0000371_diluted_coat_color	1.36694922
28	MP0003077_abnormal_cell_cycle	1.35886584
29	MP0005083_abnormal_biliary_tract	1.35548769
30	MP0008007_abnormal_cellular_replicative	1.35075263
31	MP0004957_abnormal_blastocyst_morpholog	1.28817905
32	MP0000372_irregular_coat_pigmentation	1.27977762
33	MP0005410_abnormal_fertilization	1.24621205
34	MP0010329_abnormal_lipoprotein_level	1.19462813
35	MP0003656_abnormal_erythrocyte_physiolo	1.18715997
36	MP0005076_abnormal_cell_differentiation	1.18333827
37	MP0003984_embryonic_growth_retardation	1.17852602
38	MP0002088_abnormal_embryonic_growth/wei	1.17398289
39	MP0005380_embryogenesis_phenotype	1.17117407
40	MP0001672_abnormal_embryogenesis/_devel	1.17117407
41	MP0009046_muscle_twitch	1.16918250
42	MP0002139_abnormal_hepatobiliary_system	1.16899006
43	MP0005171_absent_coat_pigmentation	1.16036483
44	MP0003698_abnormal_male_reproductive	1.13971363
45	MP0005085_abnormal_gallbladder_physiolo	1.13527632
46	MP0005551_abnormal_eye_electrophysiolog	1.12655491
47	MP0001324_abnormal_eye_pigmentation	1.09909493
48	MP0002697_abnormal_eye_size	1.09670757
49	MP0010307_abnormal_tumor_latency	1.09252318
50	MP0003385_abnormal_body_wall	1.09030016
51	MP0004272_abnormal_basement_membrane	1.07814984
52	MP0009672_abnormal_birth_weight	1.06449665
53	MP0009703_decreased_birth_body	1.05745986
54	MP0001915_intracranial_hemorrhage	1.05718534
55	MP0003693_abnormal_embryo_hatching	1.05601136
56	MP0005395_other_phenotype	1.03937145
57	MP0001929_abnormal_gametogenesis	1.03285513
58	MP0001697_abnormal_embryo_size	1.03017074
59	MP0004264_abnormal_extraembryonic_tissu	1.02946877
60	MP0005647_abnormal_sex_gland	1.02620904
61	MP0005365_abnormal_bile_salt	1.02579500
62	MP0005670_abnormal_white_adipose	1.02358596
63	MP0010678_abnormal_skin_adnexa	1.02075863
64	MP0001730_embryonic_growth_arrest	1.00660103
65	MP0002132_abnormal_respiratory_system	1.00461426
66	MP0002084_abnormal_developmental_patter	0.98634326
67	MP0006054_spinal_hemorrhage	0.97855626
68	MP0002086_abnormal_extraembryonic_tissu	0.97773406
69	MP0003942_abnormal_urinary_system	0.97387009
70	MP0005377_hearing/vestibular/ear_phenot	0.97007158
71	MP0003878_abnormal_ear_physiology	0.97007158
72	MP0001299_abnormal_eye_distance/	0.96854720
73	MP0004197_abnormal_fetal_growth/weight/	0.95390773
74	MP0004043_abnormal_pH_regulation	0.93290758
75	MP0002085_abnormal_embryonic_tissue	0.92769998
76	MP0002075_abnormal_coat/hair_pigmentati	0.91951286
77	MP0001270_distended_abdomen	0.91457184
78	MP0002168_other_aberrant_phenotype	0.90363473
79	MP0010368_abnormal_lymphatic_system	0.89552768
80	MP0002160_abnormal_reproductive_system	0.89372319
81	MP0008932_abnormal_embryonic_tissue	0.89091274
82	MP0002396_abnormal_hematopoietic_system	0.88884470
83	MP0005409_darkened_coat_color	0.88088740
84	MP0003935_abnormal_craniofacial_develop	0.86417447
85	MP0003121_genomic_imprinting	0.85684549
86	MP0003115_abnormal_respiratory_system	0.84359904
87	MP0005174_abnormal_tail_pigmentation	0.83976544
88	MP0005646_abnormal_pituitary_gland	0.83435315
89	MP0003315_abnormal_perineum_morphology	0.81544864
90	MP0002089_abnormal_postnatal_growth/wei	0.79307263
91	MP0004134_abnormal_chest_morphology	0.78555720
92	MP0004084_abnormal_cardiac_muscle	0.78138906
93	MP0000653_abnormal_sex_gland	0.75814512
94	MP0009115_abnormal_fat_cell	0.75523483
95	MP0000678_abnormal_parathyroid_gland	0.74830145
96	MP0000428_abnormal_craniofacial_morphol	0.74782819
97	MP0006138_congestive_heart_failure	0.74649485
98	MP0001145_abnormal_male_reproductive	0.74342919
99	MP0008770_decreased_survivor_rate	0.74327229
100	MP0002210_abnormal_sex_determination	0.73505949

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chromosomal breakage induced by crosslinking agents (HP:0003221)	4.25626008
2	Chromsome breakage (HP:0040012)	4.19286721
3	Deep venous thrombosis (HP:0002625)	3.70586359
4	Prolonged partial thromboplastin time (HP:0003645)	3.47695592
5	Dysmetric saccades (HP:0000641)	3.20355001
6	Poikiloderma (HP:0001029)	3.15575780
7	Genetic anticipation (HP:0003743)	3.13857082
8	Hypobetalipoproteinemia (HP:0003563)	3.00707159
9	Acanthocytosis (HP:0001927)	2.99544113
10	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.89592625
11	Clumsiness (HP:0002312)	2.73453552
12	Gaze-evoked nystagmus (HP:0000640)	2.72762085
13	Abnormality of the nasal septum (HP:0000419)	2.71844316
14	Papillary thyroid carcinoma (HP:0002895)	2.68564605
15	Nephroblastoma (Wilms tumor) (HP:0002667)	2.67296083
16	Pancreatic islet-cell hyperplasia (HP:0004510)	2.65303139
17	Cerebellar dysplasia (HP:0007033)	2.56823536
18	Hepatoblastoma (HP:0002884)	2.56662626
19	Tubulointerstitial nephritis (HP:0001970)	2.53386082
20	Embryonal renal neoplasm (HP:0011794)	2.52875780
21	Enlarged kidneys (HP:0000105)	2.50868916
22	Abnormality of the pubic bones (HP:0003172)	2.46318592
23	Abnormality of DNA repair (HP:0003254)	2.45058799
24	Capillary hemangiomas (HP:0005306)	2.44078444
25	Abnormality of the ileum (HP:0001549)	2.37676470
26	Proximal tubulopathy (HP:0000114)	2.34114141
27	Heterotopia (HP:0002282)	2.34063488
28	Abnormality of the common coagulation pathway (HP:0010990)	2.31732829
29	Meckel diverticulum (HP:0002245)	2.30746714
30	Abnormality of the intrinsic pathway (HP:0010989)	2.28328765
31	Abnormality of cochlea (HP:0000375)	2.27232600
32	Urethral obstruction (HP:0000796)	2.26361441
33	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.17696238
34	Anal stenosis (HP:0002025)	2.17187662
35	Volvulus (HP:0002580)	2.16950723
36	Fair hair (HP:0002286)	2.16101435
37	Progressive cerebellar ataxia (HP:0002073)	2.15224582
38	Ectopic kidney (HP:0000086)	2.14576061
39	Poikilocytosis (HP:0004447)	2.11821707
40	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.09709751
41	Absent radius (HP:0003974)	2.06269511
42	Central scotoma (HP:0000603)	2.05666664
43	Decreased lacrimation (HP:0000633)	2.02638035
44	Abnormality of chromosome stability (HP:0003220)	2.02231617
45	Hypopigmentation of the fundus (HP:0007894)	2.02183197
46	Epidermoid cyst (HP:0200040)	2.00912108
47	Hypothermia (HP:0002045)	1.97996842
48	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.96812731
49	Absent forearm bone (HP:0003953)	1.96709693
50	Aplasia involving forearm bones (HP:0009822)	1.96709693
51	Acute lymphatic leukemia (HP:0006721)	1.96566332
52	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.95480652
53	Absent epiphyses (HP:0010577)	1.95480652
54	Sloping forehead (HP:0000340)	1.93773546
55	Abnormal auditory evoked potentials (HP:0006958)	1.93458398
56	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.91831823
57	Flat acetabular roof (HP:0003180)	1.91069297
58	Protruding tongue (HP:0010808)	1.89889647
59	Birth length less than 3rd percentile (HP:0003561)	1.88676120
60	Menorrhagia (HP:0000132)	1.87133403
61	Abnormality of the preputium (HP:0100587)	1.86051157
62	Blue irides (HP:0000635)	1.86045291
63	Gastroesophageal reflux (HP:0002020)	1.84206263
64	Hypolipoproteinemia (HP:0010981)	1.81321716
65	Small epiphyses (HP:0010585)	1.80597100
66	Absence seizures (HP:0002121)	1.80286463
67	Abnormality of the ischium (HP:0003174)	1.79031297
68	Abnormal tarsal ossification (HP:0008369)	1.78939325
69	Chronic hepatic failure (HP:0100626)	1.77492519
70	Hypercholesterolemia (HP:0003124)	1.76481820
71	Alacrima (HP:0000522)	1.76265441
72	Cupped ear (HP:0000378)	1.76112626
73	Tubular atrophy (HP:0000092)	1.74866258
74	Intestinal fistula (HP:0100819)	1.73465287
75	Ileus (HP:0002595)	1.72222001
76	Abnormality of the wing of the ilium (HP:0011867)	1.70654035
77	Facial hemangioma (HP:0000329)	1.69296982
78	True hermaphroditism (HP:0010459)	1.69220590
79	Cystic liver disease (HP:0006706)	1.69177424
80	Scotoma (HP:0000575)	1.68586581
81	Abnormality of the renal cortex (HP:0011035)	1.68579901
82	Neoplasm of the oral cavity (HP:0100649)	1.68388171
83	Broad alveolar ridges (HP:0000187)	1.68130509
84	Limited elbow extension (HP:0001377)	1.66827174
85	Pancreatic cysts (HP:0001737)	1.66686635
86	Embryonal neoplasm (HP:0002898)	1.66664029
87	Acute myeloid leukemia (HP:0004808)	1.65026899
88	Submucous cleft hard palate (HP:0000176)	1.63963859
89	Hypoplastic ischia (HP:0003175)	1.62912876
90	Abnormal ciliary motility (HP:0012262)	1.62660185
91	Generalized hypopigmentation of hair (HP:0011358)	1.61773874
92	Spontaneous abortion (HP:0005268)	1.60684761
93	Broad palm (HP:0001169)	1.60030858
94	Smooth philtrum (HP:0000319)	1.59552390
95	Bony spicule pigmentary retinopathy (HP:0007737)	1.59063906
96	Thyroid carcinoma (HP:0002890)	1.59025893
97	Entropion (HP:0000621)	1.58133299
98	Hypophosphatemic rickets (HP:0004912)	1.56455580
99	Midline defect of the nose (HP:0004122)	1.56174650
100	Joint hemorrhage (HP:0005261)	1.55628448

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.77719448
2	LATS1	4.37840303
3	INSRR	3.13262791
4	CDK12	3.01590191
5	ICK	2.93901972
6	EEF2K	2.27096516
7	NEK2	2.12038023
8	WNK4	2.06247749
9	STK38L	1.96660282
10	NUAK1	1.91968823
11	AKT3	1.90582207
12	BMPR1B	1.83469264
13	BRSK2	1.68263273
14	CAMK1G	1.65355392
15	PLK4	1.65254225
16	STK3	1.56184285
17	CAMK1D	1.53126661
18	STK39	1.52220868
19	MKNK2	1.51940046
20	CDC7	1.50701915
21	PBK	1.49355721
22	EIF2AK1	1.45681809
23	BRD4	1.42816726
24	FGFR4	1.40929655
25	FGFR3	1.40853494
26	NEK1	1.40728239
27	ACVR1B	1.38707377
28	WNK1	1.32563836
29	WEE1	1.32008611
30	FGFR2	1.29932938
31	TTK	1.25558890
32	MELK	1.21891295
33	CHEK2	1.19940038
34	MKNK1	1.12326001
35	MTOR	1.10906766
36	ZAK	1.07484694
37	CDK7	1.06872301
38	FGFR1	1.03398792
39	MARK3	1.02746018
40	PRKAA2	0.99435586
41	ATM	0.97964964
42	PINK1	0.95411345
43	STK38	0.94105966
44	RPS6KB2	0.92816823
45	MST1R	0.92600845
46	ATR	0.92428437
47	TNIK	0.92026688
48	PIK3CA	0.89891250
49	EIF2AK3	0.86562120
50	CHEK1	0.86257961
51	BRSK1	0.80888813
52	MAPK11	0.80397793
53	PDGFRA	0.79520596
54	PLK1	0.79368591
55	NTRK3	0.78659994
56	FLT3	0.78435311
57	TYRO3	0.76528525
58	TRPM7	0.74880487
59	RPS6KB1	0.72019584
60	PNCK	0.71037652
61	MET	0.71007873
62	SGK2	0.70758926
63	MAPKAPK5	0.70097902
64	RET	0.68409016
65	FER	0.65931351
66	CDK1	0.64274198
67	PKN2	0.61528080
68	MAP3K4	0.61212930
69	MAP3K7	0.60989553
70	PLK3	0.59785347
71	PRKAA1	0.58392658
72	CDK8	0.58285381
73	CDK3	0.56824247
74	SGK494	0.51865458
75	SGK223	0.51865458
76	CSNK1E	0.51383050
77	CDK2	0.51080517
78	SGK3	0.49859051
79	AURKB	0.49104104
80	MAPKAPK3	0.47825806
81	MAP4K2	0.47470434
82	GSK3B	0.46676062
83	CSNK1D	0.46635573
84	MAP3K10	0.46158133
85	SGK1	0.45451251
86	YES1	0.43867845
87	CDK4	0.43457365
88	ERBB4	0.41856030
89	MAPK13	0.39383366
90	PIK3CG	0.38898960
91	IRAK1	0.37395956
92	ADRBK2	0.37377240
93	PRKDC	0.37366337
94	PRKACB	0.37355279
95	MAPK14	0.36111372
96	PLK2	0.34526952
97	ERBB2	0.32996560
98	AKT1	0.32099406
99	WNK3	0.32067617
100	RPS6KA3	0.31298196

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Lysine degradation_Homo sapiens_hsa00310	2.57678829
2	Complement and coagulation cascades_Homo sapiens_hsa04610	2.33532594
3	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.29491543
4	Non-homologous end-joining_Homo sapiens_hsa03450	2.17896871
5	ABC transporters_Homo sapiens_hsa02010	2.12357333
6	Butanoate metabolism_Homo sapiens_hsa00650	2.10757768
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.03583609
8	One carbon pool by folate_Homo sapiens_hsa00670	1.98052551
9	Homologous recombination_Homo sapiens_hsa03440	1.93961284
10	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.62888972
11	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.54262728
12	Propanoate metabolism_Homo sapiens_hsa00640	1.49504930
13	Fat digestion and absorption_Homo sapiens_hsa04975	1.46793723
14	Fatty acid metabolism_Homo sapiens_hsa01212	1.42483200
15	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.42116399
16	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.41487443
17	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.36167804
18	Steroid biosynthesis_Homo sapiens_hsa00100	1.35062716
19	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.33882100
20	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.32962781
21	mRNA surveillance pathway_Homo sapiens_hsa03015	1.31041690
22	Tryptophan metabolism_Homo sapiens_hsa00380	1.30325675
23	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.29162869
24	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.28696738
25	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.25791966
26	Retinol metabolism_Homo sapiens_hsa00830	1.24427248
27	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.23295427
28	Selenocompound metabolism_Homo sapiens_hsa00450	1.23137496
29	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.23033952
30	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.22080269
31	DNA replication_Homo sapiens_hsa03030	1.21638573
32	Fatty acid degradation_Homo sapiens_hsa00071	1.20149150
33	Cell cycle_Homo sapiens_hsa04110	1.15537155
34	Sphingolipid metabolism_Homo sapiens_hsa00600	1.15403692
35	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.13475668
36	Nitrogen metabolism_Homo sapiens_hsa00910	1.11093797
37	Taste transduction_Homo sapiens_hsa04742	1.06931825
38	Histidine metabolism_Homo sapiens_hsa00340	1.06502138
39	Nucleotide excision repair_Homo sapiens_hsa03420	1.06250594
40	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.04302207
41	Ether lipid metabolism_Homo sapiens_hsa00565	1.03277456
42	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.00523074
43	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.99253622
44	Olfactory transduction_Homo sapiens_hsa04740	0.95472819
45	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.95225473
46	Basal transcription factors_Homo sapiens_hsa03022	0.94563815
47	RNA transport_Homo sapiens_hsa03013	0.92553181
48	Adherens junction_Homo sapiens_hsa04520	0.92174272
49	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.92019771
50	Glycerolipid metabolism_Homo sapiens_hsa00561	0.90524888
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.90309513
52	Arginine biosynthesis_Homo sapiens_hsa00220	0.89001061
53	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.88928086
54	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.88505978
55	Mismatch repair_Homo sapiens_hsa03430	0.85536362
56	MicroRNAs in cancer_Homo sapiens_hsa05206	0.81666835
57	p53 signaling pathway_Homo sapiens_hsa04115	0.80347638
58	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.78872995
59	PPAR signaling pathway_Homo sapiens_hsa03320	0.78423737
60	Arginine and proline metabolism_Homo sapiens_hsa00330	0.78340500
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.77700165
62	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.77566305
63	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.76650786
64	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.75704003
65	ECM-receptor interaction_Homo sapiens_hsa04512	0.71183377
66	Choline metabolism in cancer_Homo sapiens_hsa05231	0.70934779
67	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.69430203
68	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.68949994
69	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.68152727
70	Linoleic acid metabolism_Homo sapiens_hsa00591	0.67874555
71	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.67566647
72	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.66642617
73	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.66142077
74	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.63023685
75	beta-Alanine metabolism_Homo sapiens_hsa00410	0.62958547
76	Prostate cancer_Homo sapiens_hsa05215	0.62175453
77	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.60806140
78	mTOR signaling pathway_Homo sapiens_hsa04150	0.59741025
79	Hippo signaling pathway_Homo sapiens_hsa04390	0.58792987
80	Bile secretion_Homo sapiens_hsa04976	0.58563968
81	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.57404044
82	Melanoma_Homo sapiens_hsa05218	0.57323548
83	Peroxisome_Homo sapiens_hsa04146	0.55269887
84	Glioma_Homo sapiens_hsa05214	0.54641384
85	Tight junction_Homo sapiens_hsa04530	0.53408174
86	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.52365085
87	AMPK signaling pathway_Homo sapiens_hsa04152	0.50348891
88	Non-small cell lung cancer_Homo sapiens_hsa05223	0.48899351
89	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.48629083
90	Nicotine addiction_Homo sapiens_hsa05033	0.48422717
91	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.47989199
92	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.47886035
93	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.47834530
94	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.47544021
95	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.47516325
96	Small cell lung cancer_Homo sapiens_hsa05222	0.47470619
97	Pyruvate metabolism_Homo sapiens_hsa00620	0.45354628
98	Purine metabolism_Homo sapiens_hsa00230	0.45217793
99	Base excision repair_Homo sapiens_hsa03410	0.44701526
100	Glutathione metabolism_Homo sapiens_hsa00480	0.44409376

SNX18P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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