ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	nuclear pore complex assembly (GO:0051292)	6.72508908
2	nuclear pore organization (GO:0006999)	5.78117328
3	DNA unwinding involved in DNA replication (GO:0006268)	5.15271523
4	pore complex assembly (GO:0046931)	4.98770709
5	mitotic chromosome condensation (GO:0007076)	4.81645356
6	mitotic sister chromatid segregation (GO:0000070)	4.62850586
7	sister chromatid segregation (GO:0000819)	4.30599267
8	protein localization to chromosome, centromeric region (GO:0071459)	4.30398069
9	mitotic sister chromatid cohesion (GO:0007064)	4.28914567
10	regulation of translational fidelity (GO:0006450)	4.23226840
11	DNA replication checkpoint (GO:0000076)	4.20883187
12	DNA strand elongation involved in DNA replication (GO:0006271)	4.14398671
13	DNA strand elongation (GO:0022616)	4.11611054
14	protein localization to kinetochore (GO:0034501)	4.04559445
15	DNA replication initiation (GO:0006270)	3.96567226
16	protoporphyrinogen IX metabolic process (GO:0046501)	3.96470430
17	regulation of RNA export from nucleus (GO:0046831)	3.93885874
18	mitotic nuclear envelope disassembly (GO:0007077)	3.90444120
19	spliceosomal tri-snRNP complex assembly (GO:0000244)	3.89938751
20	chromosome condensation (GO:0030261)	3.72617527
21	nuclear envelope disassembly (GO:0051081)	3.71868205
22	membrane disassembly (GO:0030397)	3.71868205
23	mitotic metaphase plate congression (GO:0007080)	3.64856437
24	regulation of centriole replication (GO:0046599)	3.62018204
25	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	3.57742638
26	cellular protein complex localization (GO:0034629)	3.55970337
27	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.55062649
28	DNA duplex unwinding (GO:0032508)	3.54635183
29	telomere maintenance via semi-conservative replication (GO:0032201)	3.51638868
30	protein complex localization (GO:0031503)	3.49199517
31	DNA geometric change (GO:0032392)	3.40300234
32	heterochromatin organization (GO:0070828)	3.37787376
33	regulation of nucleobase-containing compound transport (GO:0032239)	3.28418995
34	DNA conformation change (GO:0071103)	3.27416056
35	DNA packaging (GO:0006323)	3.23233039
36	protein export from nucleus (GO:0006611)	3.23012205
37	DNA topological change (GO:0006265)	3.21523353
38	ribosome assembly (GO:0042255)	3.19430243
39	L-serine metabolic process (GO:0006563)	3.16578868
40	porphyrin-containing compound biosynthetic process (GO:0006779)	3.15193127
41	DNA synthesis involved in DNA repair (GO:0000731)	3.14425657
42	maturation of SSU-rRNA (GO:0030490)	3.13310417
43	nuclear envelope organization (GO:0006998)	3.11972852
44	regulation of mammary gland epithelial cell proliferation (GO:0033599)	3.11043907
45	non-recombinational repair (GO:0000726)	3.10310562
46	double-strand break repair via nonhomologous end joining (GO:0006303)	3.10310562
47	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.06644742
48	regulation of mitotic spindle organization (GO:0060236)	3.05782876
49	mitochondrial DNA metabolic process (GO:0032042)	3.05596443
50	negative regulation of mRNA processing (GO:0050686)	3.03090395
51	rRNA transcription (GO:0009303)	3.02398498
52	DNA replication-dependent nucleosome organization (GO:0034723)	3.01588085
53	DNA replication-dependent nucleosome assembly (GO:0006335)	3.01588085
54	metaphase plate congression (GO:0051310)	3.00494510
55	chromatin assembly (GO:0031497)	3.00388121
56	peptidyl-arginine omega-N-methylation (GO:0035247)	3.00254731
57	telomere maintenance via recombination (GO:0000722)	2.99878718
58	regulation of centrosome cycle (GO:0046605)	2.99536060
59	negative regulation of mRNA metabolic process (GO:1903312)	2.97506192
60	formation of translation preinitiation complex (GO:0001731)	2.97393593
61	regulation of centrosome duplication (GO:0010824)	2.96996066
62	ribosome biogenesis (GO:0042254)	2.90602765
63	mitotic recombination (GO:0006312)	2.87750241
64	positive regulation of DNA-dependent DNA replication (GO:2000105)	2.86663294
65	tRNA methylation (GO:0030488)	2.84218201
66	establishment of integrated proviral latency (GO:0075713)	2.80701205
67	positive regulation of chromosome segregation (GO:0051984)	2.80461250
68	COPI coating of Golgi vesicle (GO:0048205)	2.77947501
69	Golgi transport vesicle coating (GO:0048200)	2.77947501
70	erythrocyte maturation (GO:0043249)	2.75728854
71	regulation of translational termination (GO:0006449)	2.75580703
72	chromosome segregation (GO:0007059)	2.75099155
73	regulation of spindle checkpoint (GO:0090231)	2.74903901
74	pre-miRNA processing (GO:0031054)	2.74245211
75	tRNA aminoacylation for protein translation (GO:0006418)	2.73913436
76	folic acid metabolic process (GO:0046655)	2.72980399
77	folic acid-containing compound biosynthetic process (GO:0009396)	2.72421408
78	protoporphyrinogen IX biosynthetic process (GO:0006782)	2.67011598
79	histone arginine methylation (GO:0034969)	2.66157668
80	chromatin assembly or disassembly (GO:0006333)	2.66093193
81	microtubule depolymerization (GO:0007019)	2.65525987
82	hemidesmosome assembly (GO:0031581)	2.64725755
83	amino acid activation (GO:0043038)	2.64539031
84	tRNA aminoacylation (GO:0043039)	2.64539031
85	regulation of spindle organization (GO:0090224)	2.63473418
86	protein localization to chromosome (GO:0034502)	2.62504765
87	tetrapyrrole biosynthetic process (GO:0033014)	2.62190079
88	proline biosynthetic process (GO:0006561)	2.60355058
89	mRNA transport (GO:0051028)	2.55993317
90	telomere maintenance via telomere lengthening (GO:0010833)	2.53796872
91	RNA stabilization (GO:0043489)	2.53208835
92	mRNA stabilization (GO:0048255)	2.53208835
93	negative regulation of RNA splicing (GO:0033119)	2.53157822
94	establishment of chromosome localization (GO:0051303)	2.53104635
95	regulation of chromosome segregation (GO:0051983)	2.51928046
96	spindle organization (GO:0007051)	2.51669768
97	meiotic chromosome segregation (GO:0045132)	2.51603009
98	histone H2B ubiquitination (GO:0033523)	2.51322733
99	establishment of apical/basal cell polarity (GO:0035089)	2.48873763
100	regulation of translational elongation (GO:0006448)	2.48556982

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	9.57825953
2	FOXM1_23109430_ChIP-Seq_U2OS_Human	4.99039648
3	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.52726518
4	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.41604171
5	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.29022546
6	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.23430740
7	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	3.17562057
8	AR_21909140_ChIP-Seq_LNCAP_Human	2.94039163
9	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.40678687
10	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.38489568
11	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.25820772
12	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.22596159
13	XRN2_22483619_ChIP-Seq_HELA_Human	2.21351303
14	ZNF263_19887448_ChIP-Seq_K562_Human	2.18274826
15	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.18199784
16	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.15815685
17	E2F1_21310950_ChIP-Seq_MCF-7_Human	2.09944666
18	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	2.06575578
19	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.04567089
20	MYCN_18555785_ChIP-Seq_MESCs_Mouse	2.03259313
21	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.97044357
22	MYC_22102868_ChIP-Seq_BL_Human	1.96898098
23	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.88144381
24	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.80601323
25	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.80479132
26	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.80338024
27	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.78911645
28	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.74672383
29	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.72904406
30	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.72631391
31	DCP1A_22483619_ChIP-Seq_HELA_Human	1.72395368
32	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.71577200
33	KDM5A_27292631_Chip-Seq_BREAST_Human	1.65043706
34	TTF2_22483619_ChIP-Seq_HELA_Human	1.59405764
35	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.58139804
36	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.57462598
37	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.56050030
38	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.52757178
39	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.52428399
40	VDR_21846776_ChIP-Seq_THP-1_Human	1.49660037
41	TFEB_21752829_ChIP-Seq_HELA_Human	1.49231521
42	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.47670679
43	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.43903037
44	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.43783048
45	GABP_19822575_ChIP-Seq_HepG2_Human	1.40930602
46	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.40768405
47	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.40322064
48	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.40218130
49	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.38448653
50	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.34681891
51	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.30767459
52	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.29413591
53	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.27852071
54	CHD1_26751641_Chip-Seq_LNCaP_Human	1.26930955
55	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.23253341
56	NANOG_21062744_ChIP-ChIP_HESCs_Human	1.22965450
57	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.22256007
58	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.22082315
59	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.21602396
60	ATF3_27146783_Chip-Seq_COLON_Human	1.20069624
61	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.16430872
62	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.15970074
63	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.14949985
64	CIITA_25753668_ChIP-Seq_RAJI_Human	1.14170931
65	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.13717406
66	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.11967234
67	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.11142159
68	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.10315091
69	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.06912394
70	CLOCK_20551151_ChIP-Seq_293T_Human	1.06366225
71	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.05080938
72	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.04992070
73	FOXP3_21729870_ChIP-Seq_TREG_Human	1.04567169
74	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.04017141
75	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.03490157
76	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.02567814
77	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.00748599
78	GATA1_19941826_ChIP-Seq_K562_Human	0.98401597
79	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.97414612
80	RACK7_27058665_Chip-Seq_MCF-7_Human	0.97054691
81	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.95325609
82	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.95179610
83	NCOR1_26117541_ChIP-Seq_K562_Human	0.94105132
84	NKX2-5_21415370_ChIP-Seq_HL-1_Mouse	0.93857271
85	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.92947702
86	GATA1_22025678_ChIP-Seq_K562_Human	0.90836618
87	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.90621122
88	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	0.89941505
89	TP53_22127205_ChIP-Seq_IMR90_Human	0.88921696
90	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.88588174
91	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.88180296
92	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.87482184
93	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.86268983
94	UBF1/2_26484160_Chip-Seq_HMECs_Human	0.85830575
95	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.84954159
96	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.84619836
97	ELK1_19687146_ChIP-ChIP_HELA_Human	0.82874656
98	TCF7_22412390_ChIP-Seq_EML_Mouse	0.82397109
99	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.82041232
100	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.81953038

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003111_abnormal_nucleus_morphology	3.87328171
2	MP0008057_abnormal_DNA_replication	3.85800120
3	MP0010094_abnormal_chromosome_stability	3.48433752
4	MP0004957_abnormal_blastocyst_morpholog	3.03708267
5	MP0003705_abnormal_hypodermis_morpholog	2.94801072
6	MP0003077_abnormal_cell_cycle	2.87537866
7	MP0008058_abnormal_DNA_repair	2.86020790
8	MP0003693_abnormal_embryo_hatching	2.80558634
9	MP0003656_abnormal_erythrocyte_physiolo	2.75290351
10	MP0010352_gastrointestinal_tract_polyps	2.64747929
11	MP0004233_abnormal_muscle_weight	2.50119043
12	MP0004147_increased_porphyrin_level	2.49906148
13	MP0008007_abnormal_cellular_replicative	2.44246722
14	MP0005623_abnormal_meninges_morphology	2.44067031
15	MP0005076_abnormal_cell_differentiation	2.43058963
16	MP0005451_abnormal_body_composition	2.29632566
17	MP0008932_abnormal_embryonic_tissue	2.09599928
18	MP0001730_embryonic_growth_arrest	2.07518964
19	MP0005645_abnormal_hypothalamus_physiol	2.03567597
20	MP0005083_abnormal_biliary_tract	1.98811405
21	MP0000537_abnormal_urethra_morphology	1.98404181
22	MP0010307_abnormal_tumor_latency	1.79898660
23	MP0000350_abnormal_cell_proliferation	1.79127314
24	MP0003941_abnormal_skin_development	1.71648357
25	MP0003566_abnormal_cell_adhesion	1.71354597
26	MP0004185_abnormal_adipocyte_glucose	1.71087254
27	MP0002396_abnormal_hematopoietic_system	1.71042052
28	MP0001672_abnormal_embryogenesis/_devel	1.59083896
29	MP0005380_embryogenesis_phenotype	1.59083896
30	MP0002877_abnormal_melanocyte_morpholog	1.58456754
31	MP0002080_prenatal_lethality	1.53033562
32	MP0005501_abnormal_skin_physiology	1.52830162
33	MP0009697_abnormal_copulation	1.50682368
34	MP0003984_embryonic_growth_retardation	1.49788128
35	MP0000579_abnormal_nail_morphology	1.48005659
36	MP0001697_abnormal_embryo_size	1.41002861
37	MP0003786_premature_aging	1.40212443
38	MP0002088_abnormal_embryonic_growth/wei	1.40058343
39	MP0002084_abnormal_developmental_patter	1.39604837
40	MP0009672_abnormal_birth_weight	1.39508393
41	MP0002085_abnormal_embryonic_tissue	1.38430379
42	MP0002086_abnormal_extraembryonic_tissu	1.29240498
43	MP0004808_abnormal_hematopoietic_stem	1.29121239
44	MP0001661_extended_life_span	1.28438430
45	MP0010234_abnormal_vibrissa_follicle	1.28331689
46	MP0010030_abnormal_orbit_morphology	1.27415761
47	MP0001849_ear_inflammation	1.26157602
48	MP0002009_preneoplasia	1.24548176
49	MP0002697_abnormal_eye_size	1.23096211
50	MP0004197_abnormal_fetal_growth/weight/	1.16182033
51	MP0000313_abnormal_cell_death	1.14874658
52	MP0005397_hematopoietic_system_phenotyp	1.13479618
53	MP0001545_abnormal_hematopoietic_system	1.13479618
54	MP0009278_abnormal_bone_marrow	1.07166169
55	MP0002060_abnormal_skin_morphology	1.06558051
56	MP0004782_abnormal_surfactant_physiolog	1.04492573
57	MP0003453_abnormal_keratinocyte_physiol	1.04397718
58	MP0005621_abnormal_cell_physiology	1.03088183
59	MP0001529_abnormal_vocalization	1.02991612
60	MP0001915_intracranial_hemorrhage	1.01236101
61	MP0001346_abnormal_lacrimal_gland	0.99498595
62	MP0003937_abnormal_limbs/digits/tail_de	0.97588662
63	MP0002796_impaired_skin_barrier	0.97037962
64	MP0000490_abnormal_crypts_of	0.95057366
65	MP0000003_abnormal_adipose_tissue	0.93481116
66	MP0002092_abnormal_eye_morphology	0.93162142
67	MP0003221_abnormal_cardiomyocyte_apopto	0.90924946
68	MP0003115_abnormal_respiratory_system	0.90692698
69	MP0000762_abnormal_tongue_morphology	0.90453622
70	MP0005384_cellular_phenotype	0.90300266
71	MP0003123_paternal_imprinting	0.90172038
72	MP0009703_decreased_birth_body	0.86172241
73	MP0000733_abnormal_muscle_development	0.85119528
74	MP0000467_abnormal_esophagus_morphology	0.84102179
75	MP0004272_abnormal_basement_membrane	0.83421978
76	MP0003718_maternal_effect	0.81839161
77	MP0000358_abnormal_cell_content/	0.79550349
78	MP0008438_abnormal_cutaneous_collagen	0.79433732
79	MP0002098_abnormal_vibrissa_morphology	0.79143937
80	MP0000428_abnormal_craniofacial_morphol	0.78803045
81	MP0005197_abnormal_uvea_morphology	0.77648464
82	MP0003755_abnormal_palate_morphology	0.76500659
83	MP0003315_abnormal_perineum_morphology	0.73412683
84	MP0002019_abnormal_tumor_incidence	0.72477703
85	MP0003861_abnormal_nervous_system	0.72174728
86	MP0000627_abnormal_mammary_gland	0.71494219
87	MP0003942_abnormal_urinary_system	0.70176014
88	MP0000566_synostosis	0.69911818
89	MP0003935_abnormal_craniofacial_develop	0.69124411
90	MP0000534_abnormal_ureter_morphology	0.68070710
91	MP0010771_integument_phenotype	0.66785580
92	MP0002111_abnormal_tail_morphology	0.63463551
93	MP0009053_abnormal_anal_canal	0.63391646
94	MP0002249_abnormal_larynx_morphology	0.62092923
95	MP0005187_abnormal_penis_morphology	0.62054663
96	MP0001216_abnormal_epidermal_layer	0.61295466
97	MP0001299_abnormal_eye_distance/	0.60768619
98	MP0003943_abnormal_hepatobiliary_system	0.60517804
99	MP0000432_abnormal_head_morphology	0.59351385
100	MP0006035_abnormal_mitochondrial_morpho	0.59294894

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Unilateral renal agenesis (HP:0000122)	4.99814048
2	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.67387658
3	Chromsome breakage (HP:0040012)	3.51458956
4	Reticulocytosis (HP:0001923)	3.44361440
5	Ulnar bowing (HP:0003031)	3.15754947
6	Abnormality of the heme biosynthetic pathway (HP:0010472)	3.04182558
7	Poikilocytosis (HP:0004447)	2.92003030
8	Abnormality of reticulocytes (HP:0004312)	2.78317220
9	Septate vagina (HP:0001153)	2.64005125
10	Progressive muscle weakness (HP:0003323)	2.55085863
11	Hyperacusis (HP:0010780)	2.47879246
12	Abnormality of the distal phalanx of the thumb (HP:0009617)	2.45809461
13	Acute myeloid leukemia (HP:0004808)	2.38754445
14	Deviation of the thumb (HP:0009603)	2.32346386
15	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.28647620
16	Acute lymphatic leukemia (HP:0006721)	2.28027843
17	Ectopic kidney (HP:0000086)	2.27960917
18	Duplication of thumb phalanx (HP:0009942)	2.25969290
19	Long eyelashes (HP:0000527)	2.25689113
20	Sparse lateral eyebrow (HP:0005338)	2.23407327
21	Abnormality of the phalanges of the hallux (HP:0010057)	2.23353925
22	Cholelithiasis (HP:0001081)	2.19704245
23	Insomnia (HP:0100785)	2.18303141
24	Increased nuchal translucency (HP:0010880)	2.18032898
25	Proximal placement of thumb (HP:0009623)	2.16867636
26	Trismus (HP:0000211)	2.12016592
27	Long palpebral fissure (HP:0000637)	2.11829384
28	Birth length less than 3rd percentile (HP:0003561)	2.11435322
29	Squamous cell carcinoma (HP:0002860)	2.11407589
30	Spastic diplegia (HP:0001264)	2.10187202
31	Urethral obstruction (HP:0000796)	2.04073138
32	11 pairs of ribs (HP:0000878)	2.02994972
33	High anterior hairline (HP:0009890)	2.01742091
34	Septo-optic dysplasia (HP:0100842)	2.00535709
35	Abnormality of the preputium (HP:0100587)	2.00042867
36	Selective tooth agenesis (HP:0001592)	1.97701793
37	Abnormality of the calcaneus (HP:0008364)	1.96539463
38	Insidious onset (HP:0003587)	1.95466572
39	Termporal pattern (HP:0011008)	1.95466572
40	Abnormal gallbladder morphology (HP:0012437)	1.94875940
41	Missing ribs (HP:0000921)	1.93306571
42	Abnormality of the umbilical cord (HP:0010881)	1.89406963
43	Breast hypoplasia (HP:0003187)	1.88062222
44	Dysmetric saccades (HP:0000641)	1.87810394
45	Abnormality of the distal phalanges of the toes (HP:0010182)	1.87483827
46	Volvulus (HP:0002580)	1.86930114
47	Progressive hearing impairment (HP:0001730)	1.86227389
48	Abnormality of the gallbladder (HP:0005264)	1.85931398
49	Astrocytoma (HP:0009592)	1.85403415
50	Abnormality of the astrocytes (HP:0100707)	1.85403415
51	Hypoplastic pelvis (HP:0008839)	1.84273945
52	Broad face (HP:0000283)	1.84078487
53	Pterygium (HP:0001059)	1.82018881
54	Asymmetry of the thorax (HP:0001555)	1.81164473
55	Short nail (HP:0001799)	1.78801321
56	Premature rupture of membranes (HP:0001788)	1.77984111
57	Multiple enchondromatosis (HP:0005701)	1.77479829
58	Abnormality of nail color (HP:0100643)	1.75292954
59	Short thumb (HP:0009778)	1.75257846
60	Sensory axonal neuropathy (HP:0003390)	1.74641905
61	Cortical dysplasia (HP:0002539)	1.74106083
62	Duodenal stenosis (HP:0100867)	1.73492344
63	Small intestinal stenosis (HP:0012848)	1.73492344
64	Poikiloderma (HP:0001029)	1.72671336
65	Entropion (HP:0000621)	1.69344320
66	Abnormality of the salivary glands (HP:0010286)	1.68466739
67	Elbow flexion contracture (HP:0002987)	1.67642618
68	Back pain (HP:0003418)	1.65586335
69	Microvesicular hepatic steatosis (HP:0001414)	1.65563206
70	Lip pit (HP:0100267)	1.65341430
71	Abnormalities of placenta or umbilical cord (HP:0001194)	1.64847460
72	Onycholysis (HP:0001806)	1.64242518
73	Protrusio acetabuli (HP:0003179)	1.63660657
74	Cafe-au-lait spot (HP:0000957)	1.63656481
75	Facial hemangioma (HP:0000329)	1.62938189
76	Hyperbilirubinemia (HP:0002904)	1.62608102
77	Absent radius (HP:0003974)	1.61725413
78	Abnormality of the thoracic spine (HP:0100711)	1.61302908
79	Abnormality of the fetal cardiovascular system (HP:0010948)	1.60704867
80	Abnormal umbilical cord blood vessels (HP:0011403)	1.60704867
81	Single umbilical artery (HP:0001195)	1.60704867
82	Shoulder girdle muscle weakness (HP:0003547)	1.60031895
83	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.59325526
84	Overlapping toe (HP:0001845)	1.58924479
85	Papillary thyroid carcinoma (HP:0002895)	1.58861898
86	Osteolytic defects of the hand bones (HP:0009699)	1.58023494
87	Osteolytic defects of the phalanges of the hand (HP:0009771)	1.58023494
88	Abnormality of dentin (HP:0010299)	1.56379314
89	Deep philtrum (HP:0002002)	1.56253491
90	Abnormal hemoglobin (HP:0011902)	1.55937760
91	Natal tooth (HP:0000695)	1.55762805
92	Abnormality of the ileum (HP:0001549)	1.55689130
93	Meckel diverticulum (HP:0002245)	1.55201165
94	Choanal atresia (HP:0000453)	1.54864230
95	Convex nasal ridge (HP:0000444)	1.53713501
96	Breech presentation (HP:0001623)	1.53686748
97	Subcapsular cataract (HP:0000523)	1.53425619
98	Abnormality of chromosome stability (HP:0003220)	1.52686565
99	Abnormality of cochlea (HP:0000375)	1.52403506
100	Disproportionate tall stature (HP:0001519)	1.51819156

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EEF2K	4.07997462
2	EIF2AK1	3.89795957
3	CDK12	3.64767597
4	FLT3	3.25606075
5	CDC7	3.19644302
6	SMG1	2.82880625
7	TRIB3	2.50891228
8	TSSK6	2.43268300
9	ICK	2.41252212
10	TTK	2.32330840
11	BUB1	2.23533457
12	IRAK3	2.20331852
13	BRD4	2.11062040
14	MAP3K10	1.96989326
15	MST1R	1.91068301
16	SRPK1	1.76106900
17	SCYL2	1.60653148
18	CHEK2	1.60222198
19	PLK4	1.50019071
20	NME2	1.47860571
21	MTOR	1.36461143
22	PLK1	1.36085318
23	MET	1.32628268
24	CHEK1	1.31134350
25	LATS2	1.30296390
26	ATR	1.28745594
27	NEK1	1.28118298
28	EPHA2	1.25724431
29	AURKB	1.24528132
30	PLK3	1.24385165
31	CAMK1G	1.22728922
32	STK4	1.20582413
33	TTN	1.20386010
34	PBK	1.17494494
35	MAP3K8	1.16663337
36	CDK7	1.16646051
37	PRPF4B	1.14858684
38	AURKA	1.13469226
39	CDK6	1.12355576
40	CDK8	1.11972785
41	CAMK1D	1.10400371
42	MKNK1	1.06644223
43	NEK2	1.06044146
44	PAK2	1.03016982
45	PNCK	1.02625961
46	CDK4	1.02582675
47	RPS6KB2	1.02539578
48	PAK4	0.96918153
49	SIK1	0.92922926
50	TAOK2	0.84700680
51	PIM2	0.83094570
52	CDK2	0.82938537
53	IRAK2	0.82516142
54	PTK2	0.82355920
55	BRSK2	0.81465953
56	BRAF	0.81418888
57	CDK1	0.80936993
58	WEE1	0.80028622
59	PKN2	0.77777489
60	ATM	0.77395157
61	DYRK3	0.74948117
62	NTRK1	0.72701861
63	MAP2K3	0.72598818
64	CLK1	0.72330384
65	BRSK1	0.71513312
66	NEK9	0.70461165
67	LATS1	0.70316276
68	STK10	0.69210894
69	VRK2	0.68730642
70	PIM1	0.68475732
71	CDK9	0.66108509
72	RPS6KA4	0.65766636
73	ERBB4	0.61801755
74	TAOK1	0.61634917
75	AKT2	0.58363797
76	RPS6KA2	0.54998989
77	RPS6KL1	0.51330540
78	RPS6KC1	0.51330540
79	BMX	0.50519904
80	CCNB1	0.46006630
81	MAPK14	0.45598103
82	MAPK11	0.44953182
83	PRKDC	0.44686480
84	PDGFRA	0.43562794
85	STK38	0.42833964
86	GSK3B	0.42395171
87	TRPM7	0.42271596
88	TAF1	0.40166102
89	SIK2	0.40150369
90	RPS6KA5	0.38604024
91	CSNK1E	0.36430130
92	RPS6KA6	0.35684842
93	MAPKAPK5	0.34996587
94	MAP2K2	0.34558689
95	PDK2	0.33979125
96	RPS6KA1	0.33735138
97	MAPK10	0.33516934
98	YES1	0.32723656
99	RPS6KB1	0.31662376
100	MAPK9	0.31637755

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	3.98958756
2	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	3.43847306
3	Non-homologous end-joining_Homo sapiens_hsa03450	3.10066064
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.92880586
5	Cell cycle_Homo sapiens_hsa04110	2.74424573
6	RNA transport_Homo sapiens_hsa03013	2.50855457
7	Mismatch repair_Homo sapiens_hsa03430	2.47633641
8	Base excision repair_Homo sapiens_hsa03410	2.16842245
9	Nucleotide excision repair_Homo sapiens_hsa03420	2.13939557
10	Spliceosome_Homo sapiens_hsa03040	2.10700847
11	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.03841569
12	One carbon pool by folate_Homo sapiens_hsa00670	1.95027921
13	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.84620383
14	mRNA surveillance pathway_Homo sapiens_hsa03015	1.75842921
15	Central carbon metabolism in cancer_Homo sapiens_hsa05230	1.62525951
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.61919606
17	Thyroid cancer_Homo sapiens_hsa05216	1.61023195
18	Lysine degradation_Homo sapiens_hsa00310	1.58073176
19	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.54061072
20	Bladder cancer_Homo sapiens_hsa05219	1.49986740
21	Small cell lung cancer_Homo sapiens_hsa05222	1.45221712
22	Selenocompound metabolism_Homo sapiens_hsa00450	1.41661987
23	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.38484120
24	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.37265819
25	Homologous recombination_Homo sapiens_hsa03440	1.30676671
26	Pyrimidine metabolism_Homo sapiens_hsa00240	1.24770342
27	p53 signaling pathway_Homo sapiens_hsa04115	1.23860898
28	MicroRNAs in cancer_Homo sapiens_hsa05206	1.23410216
29	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.18343888
30	Non-small cell lung cancer_Homo sapiens_hsa05223	1.13463830
31	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.11418418
32	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.08335983
33	Oocyte meiosis_Homo sapiens_hsa04114	1.05704396
34	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.01509656
35	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.00512178
36	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.99927559
37	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.97859883
38	Carbon metabolism_Homo sapiens_hsa01200	0.97127242
39	RNA polymerase_Homo sapiens_hsa03020	0.95959829
40	Pentose phosphate pathway_Homo sapiens_hsa00030	0.94171668
41	Basal transcription factors_Homo sapiens_hsa03022	0.93468935
42	Hippo signaling pathway_Homo sapiens_hsa04390	0.92851064
43	Pancreatic cancer_Homo sapiens_hsa05212	0.90972113
44	mTOR signaling pathway_Homo sapiens_hsa04150	0.89983425
45	Pyruvate metabolism_Homo sapiens_hsa00620	0.89963545
46	Sulfur relay system_Homo sapiens_hsa04122	0.86234586
47	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.85673125
48	Prostate cancer_Homo sapiens_hsa05215	0.83171512
49	AMPK signaling pathway_Homo sapiens_hsa04152	0.82778153
50	Purine metabolism_Homo sapiens_hsa00230	0.82327605
51	Endometrial cancer_Homo sapiens_hsa05213	0.80411379
52	Adherens junction_Homo sapiens_hsa04520	0.78965049
53	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.76602068
54	Viral carcinogenesis_Homo sapiens_hsa05203	0.75541034
55	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.75289440
56	Glioma_Homo sapiens_hsa05214	0.73727582
57	Acute myeloid leukemia_Homo sapiens_hsa05221	0.71754547
58	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.71400738
59	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.71275186
60	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.70831706
61	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.70645378
62	Steroid biosynthesis_Homo sapiens_hsa00100	0.68104401
63	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.65152584
64	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.64669908
65	ECM-receptor interaction_Homo sapiens_hsa04512	0.63956626
66	Arginine biosynthesis_Homo sapiens_hsa00220	0.63847994
67	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.61347913
68	Proteoglycans in cancer_Homo sapiens_hsa05205	0.58935188
69	Renal cell carcinoma_Homo sapiens_hsa05211	0.57833939
70	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.56651364
71	Alcoholism_Homo sapiens_hsa05034	0.56362235
72	Melanoma_Homo sapiens_hsa05218	0.56230376
73	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.56015458
74	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.54685905
75	Notch signaling pathway_Homo sapiens_hsa04330	0.54517463
76	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.54186459
77	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.54168021
78	Colorectal cancer_Homo sapiens_hsa05210	0.52671541
79	RNA degradation_Homo sapiens_hsa03018	0.52497772
80	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.51014941
81	HTLV-I infection_Homo sapiens_hsa05166	0.50722059
82	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.49407654
83	Wnt signaling pathway_Homo sapiens_hsa04310	0.47865355
84	Focal adhesion_Homo sapiens_hsa04510	0.46922684
85	Basal cell carcinoma_Homo sapiens_hsa05217	0.46204934
86	Apoptosis_Homo sapiens_hsa04210	0.43799152
87	Pathways in cancer_Homo sapiens_hsa05200	0.42047747
88	Galactose metabolism_Homo sapiens_hsa00052	0.41915142
89	ErbB signaling pathway_Homo sapiens_hsa04012	0.40498857
90	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.40325521
91	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.40314550
92	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.40180711
93	Insulin signaling pathway_Homo sapiens_hsa04910	0.37602155
94	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.36120788
95	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.35891870
96	Glucagon signaling pathway_Homo sapiens_hsa04922	0.33305067
97	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.32066560
98	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.32038855
99	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.31184500
100	Hepatitis B_Homo sapiens_hsa05161	0.31130320

SNX18P7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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