ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	peptidyl-tyrosine autophosphorylation (GO:0038083)	7.58511834
2	protein heterotetramerization (GO:0051290)	5.81815117
3	positive regulation of respiratory burst (GO:0060267)	5.41492423
4	histone H2A acetylation (GO:0043968)	5.23474531
5	exocrine pancreas development (GO:0031017)	5.02159687
6	righting reflex (GO:0060013)	4.86986776
7	respiratory chain complex IV assembly (GO:0008535)	4.79564125
8	negative regulation of protein localization to cell surface (GO:2000009)	4.78259307
9	positive regulation of glycolytic process (GO:0045821)	4.54799357
10	heparin biosynthetic process (GO:0030210)	4.52978029
11	heparin metabolic process (GO:0030202)	4.52978029
12	acrosome reaction (GO:0007340)	4.44807652
13	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	4.39801487
14	regulation of mitotic spindle checkpoint (GO:1903504)	4.39801487
15	histone H3-K9 demethylation (GO:0033169)	4.37142056
16	rRNA methylation (GO:0031167)	4.21459181
17	multicellular organism reproduction (GO:0032504)	4.11145369
18	cytochrome complex assembly (GO:0017004)	4.01140403
19	microtubule severing (GO:0051013)	3.89228394
20	urate metabolic process (GO:0046415)	3.80481752
21	endothelium development (GO:0003158)	3.78312449
22	male sex determination (GO:0030238)	3.75795615
23	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.75041079
24	adenosine metabolic process (GO:0046085)	3.73673523
25	positive regulation of meiosis (GO:0045836)	3.59339332
26	rRNA modification (GO:0000154)	3.49861688
27	reflex (GO:0060004)	3.43135800
28	positive regulation of endothelial cell differentiation (GO:0045603)	3.39447540
29	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.36397598
30	protein complex biogenesis (GO:0070271)	3.36363966
31	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	3.33981846
32	sleep (GO:0030431)	3.32147815
33	positive regulation of meiotic cell cycle (GO:0051446)	3.30546108
34	mitochondrial respiratory chain complex assembly (GO:0033108)	3.30500616
35	RNA destabilization (GO:0050779)	3.27614846
36	positive regulation of histone H3-K4 methylation (GO:0051571)	3.23982722
37	sperm-egg recognition (GO:0035036)	3.22531230
38	protein K63-linked deubiquitination (GO:0070536)	3.22344951
39	purine-containing compound salvage (GO:0043101)	3.16595247
40	transcription from mitochondrial promoter (GO:0006390)	3.15519278
41	glycosphingolipid biosynthetic process (GO:0006688)	3.14797578
42	negative regulation of Notch signaling pathway (GO:0045746)	3.14298915
43	glycine transport (GO:0015816)	3.14212193
44	negative regulation of neurological system process (GO:0031645)	3.14025902
45	retinal cone cell development (GO:0046549)	3.07773441
46	preassembly of GPI anchor in ER membrane (GO:0016254)	3.07412196
47	gamma-aminobutyric acid transport (GO:0015812)	3.04354500
48	base-excision repair, AP site formation (GO:0006285)	3.01458513
49	response to gravity (GO:0009629)	3.00404635
50	negative regulation of heart rate (GO:0010459)	2.99078437
51	binding of sperm to zona pellucida (GO:0007339)	2.96595623
52	phosphate ion transport (GO:0006817)	2.94783308
53	regulation of spindle checkpoint (GO:0090231)	2.94423236
54	detection of light stimulus involved in sensory perception (GO:0050962)	2.94306217
55	detection of light stimulus involved in visual perception (GO:0050908)	2.94306217
56	single fertilization (GO:0007338)	2.92544106
57	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.90647659
58	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.90603719
59	replication fork processing (GO:0031297)	2.89589543
60	regulation of endothelial cell differentiation (GO:0045601)	2.89324843
61	mitochondrial RNA metabolic process (GO:0000959)	2.87714138
62	positive regulation of action potential (GO:0045760)	2.86093923
63	piRNA metabolic process (GO:0034587)	2.84876713
64	tachykinin receptor signaling pathway (GO:0007217)	2.84553406
65	regulation of respiratory burst (GO:0060263)	2.83700218
66	hypothalamus development (GO:0021854)	2.81019530
67	regulation of defense response to virus by host (GO:0050691)	2.80553100
68	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	2.80455645
69	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.78542140
70	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.77129159
71	oocyte development (GO:0048599)	2.74663357
72	positive regulation of glycogen biosynthetic process (GO:0045725)	2.73943646
73	regulation of acrosome reaction (GO:0060046)	2.73000499
74	regulation of RIG-I signaling pathway (GO:0039535)	2.72522367
75	reproduction (GO:0000003)	2.68908765
76	proteasome assembly (GO:0043248)	2.66527563
77	regulation of meiosis I (GO:0060631)	2.66047379
78	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.65887886
79	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.65887886
80	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.65727014
81	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.65727014
82	NADH dehydrogenase complex assembly (GO:0010257)	2.65727014
83	glycerophospholipid catabolic process (GO:0046475)	2.64747033
84	cell-cell recognition (GO:0009988)	2.61317777
85	protein K6-linked ubiquitination (GO:0085020)	2.61207709
86	negative regulation of Rho protein signal transduction (GO:0035024)	2.61029552
87	adaptation of signaling pathway (GO:0023058)	2.60674593
88	translesion synthesis (GO:0019985)	2.60120272
89	proline transport (GO:0015824)	2.59748269
90	histone H4-K12 acetylation (GO:0043983)	2.58821029
91	protein K48-linked deubiquitination (GO:0071108)	2.58626650
92	protein K11-linked deubiquitination (GO:0035871)	2.58353250
93	leukotriene biosynthetic process (GO:0019370)	2.56233332
94	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.56038611
95	positive regulation of T cell chemotaxis (GO:0010820)	2.55929746
96	regulation of T cell chemotaxis (GO:0010819)	2.55929746
97	regulation of centriole replication (GO:0046599)	2.55807560
98	calcium ion-dependent exocytosis (GO:0017156)	2.54597036
99	positive regulation of actin filament depolymerization (GO:0030836)	2.54356160
100	DNA methylation involved in gamete generation (GO:0043046)	2.54223646

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FLI1_27457419_Chip-Seq_LIVER_Mouse	3.79746161
2	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.54679830
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.17348373
4	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.16601698
5	PCGF2_27294783_Chip-Seq_ESCs_Mouse	3.08994926
6	GATA1_22025678_ChIP-Seq_K562_Human	2.94257359
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.88751541
8	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.84649930
9	VDR_22108803_ChIP-Seq_LS180_Human	2.71698312
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.58562772
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.57676665
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.36211778
13	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.33235986
14	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.31528671
15	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.26471988
16	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.26103038
17	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.23099127
18	GBX2_23144817_ChIP-Seq_PC3_Human	2.20591484
19	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.14905690
20	P300_19829295_ChIP-Seq_ESCs_Human	2.08060596
21	FUS_26573619_Chip-Seq_HEK293_Human	2.06120996
22	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.91444814
23	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.88679465
24	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.88122116
25	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.83567243
26	ELK1_19687146_ChIP-ChIP_HELA_Human	1.76923797
27	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.76568789
28	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.75842392
29	BCAT_22108803_ChIP-Seq_LS180_Human	1.71284968
30	TAF15_26573619_Chip-Seq_HEK293_Human	1.69329405
31	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.65882933
32	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.57689130
33	STAT3_23295773_ChIP-Seq_U87_Human	1.57518796
34	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.56065446
35	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.55099915
36	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.53435570
37	EWS_26573619_Chip-Seq_HEK293_Human	1.53396280
38	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.53141873
39	ER_23166858_ChIP-Seq_MCF-7_Human	1.49480648
40	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.48868011
41	AR_25329375_ChIP-Seq_VCAP_Human	1.47179155
42	VDR_23849224_ChIP-Seq_CD4+_Human	1.42252659
43	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.41870787
44	NCOR_22424771_ChIP-Seq_293T_Human	1.41460924
45	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.40691855
46	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.39265338
47	SMAD4_21799915_ChIP-Seq_A2780_Human	1.37761606
48	MYC_18940864_ChIP-ChIP_HL60_Human	1.37392977
49	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.37276377
50	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.34469949
51	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.34175841
52	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.33826897
53	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.33505302
54	CBP_20019798_ChIP-Seq_JUKART_Human	1.33505302
55	TP53_22573176_ChIP-Seq_HFKS_Human	1.31417096
56	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.31340062
57	RUNX2_22187159_ChIP-Seq_PCA_Human	1.31264740
58	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.31206399
59	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.30930984
60	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.30374379
61	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.29668849
62	TCF4_22108803_ChIP-Seq_LS180_Human	1.27340914
63	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.27096361
64	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.24535449
65	GATA3_26560356_Chip-Seq_TH2_Human	1.23181822
66	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.21443073
67	CDX2_22108803_ChIP-Seq_LS180_Human	1.21164713
68	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.19548100
69	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.18576798
70	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.16521972
71	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.16521924
72	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.16419945
73	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.15578328
74	TCF4_23295773_ChIP-Seq_U87_Human	1.13469903
75	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.13156974
76	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.12068812
77	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.12068812
78	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.11478687
79	CJUN_26792858_Chip-Seq_BT549_Human	1.10505007
80	AR_20517297_ChIP-Seq_VCAP_Human	1.10209926
81	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.10162047
82	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.09548599
83	P53_22387025_ChIP-Seq_ESCs_Mouse	1.09228936
84	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.08671326
85	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.08010013
86	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.07126872
87	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.06998633
88	KDM2B_26808549_Chip-Seq_REH_Human	1.05400284
89	SOX2_19829295_ChIP-Seq_ESCs_Human	1.04931591
90	NANOG_19829295_ChIP-Seq_ESCs_Human	1.04931591
91	JUN_21703547_ChIP-Seq_K562_Human	1.04652620
92	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.04575316
93	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.04306475
94	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.04208751
95	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.03881847
96	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.03181196
97	BRD4_25478319_ChIP-Seq_HGPS_Human	1.02828064
98	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.02463602
99	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.02452144
100	IRF1_19129219_ChIP-ChIP_H3396_Human	1.01661397

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005645_abnormal_hypothalamus_physiol	6.09097122
2	MP0002102_abnormal_ear_morphology	4.28528596
3	MP0000465_gastrointestinal_hemorrhage	3.93165323
4	MP0005646_abnormal_pituitary_gland	3.32777015
5	MP0002138_abnormal_hepatobiliary_system	3.28879798
6	MP0005084_abnormal_gallbladder_morpholo	2.99729174
7	MP0005410_abnormal_fertilization	2.94243224
8	MP0005220_abnormal_exocrine_pancreas	2.52669782
9	MP0006072_abnormal_retinal_apoptosis	2.40487199
10	MP0008877_abnormal_DNA_methylation	2.29520735
11	MP0006035_abnormal_mitochondrial_morpho	2.28267520
12	MP0002332_abnormal_exercise_endurance	2.26132806
13	MP0003724_increased_susceptibility_to	2.14669229
14	MP0003011_delayed_dark_adaptation	2.06439202
15	MP0004043_abnormal_pH_regulation	2.04153891
16	MP0009764_decreased_sensitivity_to	2.01877310
17	MP0009765_abnormal_xenobiotic_induced	1.93646828
18	MP0002837_dystrophic_cardiac_calcinosis	1.93404977
19	MP0003183_abnormal_peptide_metabolism	1.90775632
20	MP0005551_abnormal_eye_electrophysiolog	1.89545176
21	MP0000427_abnormal_hair_cycle	1.84471092
22	MP0005647_abnormal_sex_gland	1.77570519
23	MP0005253_abnormal_eye_physiology	1.67976341
24	MP0002822_catalepsy	1.64541826
25	MP0002693_abnormal_pancreas_physiology	1.64487502
26	MP0010368_abnormal_lymphatic_system	1.58123053
27	MP0001929_abnormal_gametogenesis	1.56254890
28	MP0000013_abnormal_adipose_tissue	1.54283787
29	MP0004019_abnormal_vitamin_homeostasis	1.39897957
30	MP0003950_abnormal_plasma_membrane	1.39560662
31	MP0008875_abnormal_xenobiotic_pharmacok	1.38170241
32	MP0010094_abnormal_chromosome_stability	1.38161617
33	MP0001905_abnormal_dopamine_level	1.38042558
34	MP0006036_abnormal_mitochondrial_physio	1.37037639
35	MP0008058_abnormal_DNA_repair	1.36218816
36	MP0001984_abnormal_olfaction	1.32089502
37	MP0001501_abnormal_sleep_pattern	1.27837284
38	MP0003693_abnormal_embryo_hatching	1.27721452
39	MP0003698_abnormal_male_reproductive	1.27676079
40	MP0002166_altered_tumor_susceptibility	1.26599044
41	MP0005365_abnormal_bile_salt	1.25141259
42	MP0002733_abnormal_thermal_nociception	1.21748048
43	MP0001879_abnormal_lymphatic_vessel	1.17038570
44	MP0002009_preneoplasia	1.10980473
45	MP0010386_abnormal_urinary_bladder	1.10923258
46	MP0000230_abnormal_systemic_arterial	1.08743072
47	MP0001529_abnormal_vocalization	1.06913326
48	MP0001756_abnormal_urination	1.05532589
49	MP0003646_muscle_fatigue	1.03952642
50	MP0004142_abnormal_muscle_tone	1.03909031
51	MP0003786_premature_aging	1.03701582
52	MP0002006_tumorigenesis	0.98167646
53	MP0009785_altered_susceptibility_to	0.97224102
54	MP0002736_abnormal_nociception_after	0.95201442
55	MP0001944_abnormal_pancreas_morphology	0.94707900
56	MP0009046_muscle_twitch	0.93297225
57	MP0009697_abnormal_copulation	0.93239046
58	MP0009333_abnormal_splenocyte_physiolog	0.91353405
59	MP0001486_abnormal_startle_reflex	0.89590339
60	MP0005165_increased_susceptibility_to	0.89197119
61	MP0001764_abnormal_homeostasis	0.89055666
62	MP0001542_abnormal_bone_strength	0.88900816
63	MP0003283_abnormal_digestive_organ	0.88424311
64	MP0004085_abnormal_heartbeat	0.88343563
65	MP0000653_abnormal_sex_gland	0.87595254
66	MP0005397_hematopoietic_system_phenotyp	0.87267099
67	MP0001545_abnormal_hematopoietic_system	0.87267099
68	MP0009780_abnormal_chondrocyte_physiolo	0.84788873
69	MP0003718_maternal_effect	0.82931452
70	MP0001119_abnormal_female_reproductive	0.82568045
71	MP0003137_abnormal_impulse_conducting	0.81762641
72	MP0003186_abnormal_redox_activity	0.81721413
73	MP0005389_reproductive_system_phenotype	0.81307966
74	MP0004147_increased_porphyrin_level	0.81040593
75	MP0000358_abnormal_cell_content/	0.79274112
76	MP0001145_abnormal_male_reproductive	0.78858662
77	MP0008775_abnormal_heart_ventricle	0.77483153
78	MP0001270_distended_abdomen	0.77178841
79	MP0002229_neurodegeneration	0.77005868
80	MP0005319_abnormal_enzyme/_coenzyme	0.75506884
81	MP0005636_abnormal_mineral_homeostasis	0.74818636
82	MP0002210_abnormal_sex_determination	0.71430983
83	MP0002295_abnormal_pulmonary_circulatio	0.70442509
84	MP0002160_abnormal_reproductive_system	0.69757690
85	MP0005334_abnormal_fat_pad	0.68901790
86	MP0005367_renal/urinary_system_phenotyp	0.68349297
87	MP0000516_abnormal_urinary_system	0.68349297
88	MP0010307_abnormal_tumor_latency	0.66831484
89	MP0002161_abnormal_fertility/fecundity	0.66499653
90	MP0001664_abnormal_digestion	0.66297264
91	MP0001243_abnormal_dermal_layer	0.65447321
92	MP0002254_reproductive_system_inflammat	0.65240673
93	MP0009763_increased_sensitivity_to	0.64946496
94	MP0004215_abnormal_myocardial_fiber	0.64147502
95	MP0000383_abnormal_hair_follicle	0.63464829
96	MP0001765_abnormal_ion_homeostasis	0.62673762
97	MP0005595_abnormal_vascular_smooth	0.62057528
98	MP0009672_abnormal_birth_weight	0.60945493
99	MP0002069_abnormal_eating/drinking_beha	0.60028076
100	MP0003828_pulmonary_edema	0.59640600

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypoglycemic seizures (HP:0002173)	6.13666019
2	Hypoglycemic coma (HP:0001325)	6.09035272
3	Pancreatic islet-cell hyperplasia (HP:0004510)	5.01355031
4	Enlarged penis (HP:0000040)	4.94809743
5	Congenital, generalized hypertrichosis (HP:0004540)	4.93773288
6	Hyperinsulinemic hypoglycemia (HP:0000825)	4.87547892
7	Long foot (HP:0001833)	4.65331155
8	Thick nail (HP:0001805)	4.34718050
9	Reduced subcutaneous adipose tissue (HP:0003758)	4.25422372
10	Ketoacidosis (HP:0001993)	4.03383627
11	Symptomatic seizures (HP:0011145)	4.00927808
12	Abnormality of endocrine pancreas physiology (HP:0012093)	3.90935104
13	Abnormality of the pancreatic islet cells (HP:0006476)	3.90935104
14	Tubulointerstitial nephritis (HP:0001970)	3.67805502
15	Generalized aminoaciduria (HP:0002909)	3.58630361
16	Tongue fasciculations (HP:0001308)	3.44474010
17	Hyperglycemia (HP:0003074)	3.42526349
18	Attenuation of retinal blood vessels (HP:0007843)	3.30130884
19	Growth hormone excess (HP:0000845)	3.20589402
20	Progressive inability to walk (HP:0002505)	3.07352892
21	Insulin-resistant diabetes mellitus (HP:0000831)	3.01686180
22	Renal cortical cysts (HP:0000803)	2.94759435
23	Degeneration of anterior horn cells (HP:0002398)	2.93957751
24	Abnormality of the anterior horn cell (HP:0006802)	2.93957751
25	Muscle fibrillation (HP:0010546)	2.90015716
26	Abolished electroretinogram (ERG) (HP:0000550)	2.82415387
27	Methylmalonic acidemia (HP:0002912)	2.75572709
28	Congenital sensorineural hearing impairment (HP:0008527)	2.75251058
29	Hypokinesia (HP:0002375)	2.66484825
30	Inability to walk (HP:0002540)	2.65934234
31	Pendular nystagmus (HP:0012043)	2.62660705
32	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.53103597
33	Congenital stationary night blindness (HP:0007642)	2.42051085
34	Keratoconus (HP:0000563)	2.39893045
35	Increased corneal curvature (HP:0100692)	2.39893045
36	Proximal tubulopathy (HP:0000114)	2.37146020
37	Facial diplegia (HP:0001349)	2.36029994
38	Abnormality of vitamin B metabolism (HP:0004340)	2.34974087
39	Methylmalonic aciduria (HP:0012120)	2.30955594
40	J-shaped sella turcica (HP:0002680)	2.27531503
41	3-Methylglutaconic aciduria (HP:0003535)	2.23204644
42	Failure to thrive in infancy (HP:0001531)	2.19616323
43	Abnormality of the renal cortex (HP:0011035)	2.18388285
44	Ketosis (HP:0001946)	2.14756260
45	Abnormality of macular pigmentation (HP:0008002)	2.12999912
46	Chorioretinal atrophy (HP:0000533)	2.12649085
47	Severe visual impairment (HP:0001141)	2.12293057
48	Median cleft lip (HP:0000161)	2.11666778
49	Hepatic necrosis (HP:0002605)	2.11435655
50	Adactyly (HP:0009776)	2.09703509
51	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.07505627
52	Pancreatic fibrosis (HP:0100732)	2.03573464
53	Hyperpituitarism (HP:0010514)	1.97121173
54	Short tibia (HP:0005736)	1.97102030
55	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.95706899
56	Abnormality of alanine metabolism (HP:0010916)	1.95706899
57	Hyperalaninemia (HP:0003348)	1.95706899
58	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.95412783
59	Hyperglycinemia (HP:0002154)	1.94765747
60	Neonatal respiratory distress (HP:0002643)	1.94499495
61	Hepatocellular necrosis (HP:0001404)	1.93966583
62	Large hands (HP:0001176)	1.93113743
63	Tubulointerstitial abnormality (HP:0001969)	1.90130771
64	Type I transferrin isoform profile (HP:0003642)	1.88225935
65	Abnormal protein glycosylation (HP:0012346)	1.87094394
66	Abnormal glycosylation (HP:0012345)	1.87094394
67	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.87094394
68	Abnormal protein N-linked glycosylation (HP:0012347)	1.87094394
69	Amyotrophic lateral sclerosis (HP:0007354)	1.84904282
70	Abnormality of dental color (HP:0011073)	1.84227468
71	Elfin facies (HP:0004428)	1.82713390
72	Increased intramyocellular lipid droplets (HP:0012240)	1.82124841
73	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.81963930
74	Insulin resistance (HP:0000855)	1.79713652
75	Pancreatic cysts (HP:0001737)	1.79607036
76	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.76924150
77	Constricted visual fields (HP:0001133)	1.73728751
78	Clubbing of toes (HP:0100760)	1.73711896
79	Hypothermia (HP:0002045)	1.70536494
80	Delayed CNS myelination (HP:0002188)	1.69359281
81	Medial flaring of the eyebrow (HP:0010747)	1.69030857
82	Glycosuria (HP:0003076)	1.66401113
83	Abnormality of urine glucose concentration (HP:0011016)	1.66401113
84	Submucous cleft hard palate (HP:0000176)	1.65113703
85	Decreased central vision (HP:0007663)	1.65081111
86	Meckel diverticulum (HP:0002245)	1.64879570
87	True hermaphroditism (HP:0010459)	1.64213191
88	Increased muscle lipid content (HP:0009058)	1.63793670
89	Increased CSF lactate (HP:0002490)	1.62394924
90	Chronic bronchitis (HP:0004469)	1.62295093
91	Accelerated skeletal maturation (HP:0005616)	1.62010347
92	Mitochondrial inheritance (HP:0001427)	1.61698677
93	Type 2 muscle fiber atrophy (HP:0003554)	1.61289384
94	Optic nerve hypoplasia (HP:0000609)	1.60711767
95	Hematochezia (HP:0002573)	1.60361908
96	Abnormality of the ileum (HP:0001549)	1.58736147
97	Small for gestational age (HP:0001518)	1.58671744
98	Zonular cataract (HP:0010920)	1.58447602
99	Bony spicule pigmentary retinopathy (HP:0007737)	1.56463115
100	Congenital hepatic fibrosis (HP:0002612)	1.55979457

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.09602741
2	MAP4K2	2.72921607
3	TSSK6	2.07675677
4	ADRBK2	2.07174326
5	INSRR	11.2968616
6	MST4	1.97482029
7	EIF2AK3	1.89074923
8	GRK7	1.70522633
9	TXK	1.64829264
10	STK16	1.63842779
11	FER	1.52764113
12	BMPR1B	1.51642637
13	GRK1	1.47233315
14	TRIM28	1.45198195
15	SRPK1	1.43539839
16	MAP2K7	1.39029910
17	PIK3CG	1.37492504
18	ZAK	1.37448301
19	BUB1	1.27492375
20	IKBKE	1.26205985
21	STK38L	1.25508268
22	WNK3	1.24679059
23	TAOK3	1.09644267
24	FES	1.08069064
25	STK24	1.07744076
26	TIE1	1.06959444
27	TBK1	1.04106516
28	PLK4	1.02164333
29	PLK2	0.96445585
30	JAK3	0.93769091
31	CSNK1G1	0.93144394
32	DAPK1	0.92841908
33	EIF2AK1	0.89339335
34	EPHB1	0.88389257
35	CSNK1G2	0.86249924
36	NUAK1	0.85500090
37	PTK2B	0.84194792
38	MAP3K3	0.83846046
39	IKBKB	0.82543457
40	MKNK1	0.82083088
41	CSNK1G3	0.81441844
42	MET	0.81304668
43	AURKA	0.78424263
44	MYLK	0.77909000
45	EIF2AK2	0.75393478
46	TESK1	0.73025815
47	CSNK1A1L	0.72254380
48	PAK3	0.69968181
49	LIMK1	0.69930631
50	PIM2	0.69082975
51	KDR	0.68427294
52	TEC	0.66552241
53	ADRBK1	0.64218059
54	NEK9	0.62763458
55	MAPKAPK5	0.60472884
56	IRAK1	0.58945849
57	IGF1R	0.58553656
58	PHKG1	0.58480350
59	PHKG2	0.58480350
60	BCKDK	0.58302068
61	STK39	0.58152613
62	TRPM7	0.57857704
63	DAPK2	0.52836807
64	CDK8	0.51806809
65	MAP2K3	0.51132061
66	GRK6	0.49888683
67	TGFBR2	0.49274596
68	TNK2	0.48000710
69	MAP3K4	0.47248214
70	ACVR1B	0.47041079
71	LYN	0.46808077
72	ERBB4	0.46173363
73	KIT	0.45609405
74	PRKCE	0.45385497
75	PLK3	0.44452968
76	PBK	0.43516444
77	PINK1	0.43492324
78	MAP2K6	0.42901548
79	FLT3	0.42418529
80	GRK5	0.41434484
81	PLK1	0.40988453
82	CSF1R	0.40255839
83	INSR	0.39407380
84	PAK4	0.37746381
85	MAP3K14	0.36127987
86	MAP4K1	0.36021724
87	RPS6KA5	0.35537864
88	ABL2	0.33516686
89	ABL1	0.33216778
90	OXSR1	0.30070047
91	CAMK2A	0.27995657
92	STK10	0.26422546
93	ERBB3	0.24589102
94	LCK	0.23723016
95	IRAK3	0.23491456
96	TLK1	0.23479389
97	TGFBR1	0.22920257
98	TESK2	0.22863937
99	GSK3A	0.22701629
100	CHEK2	0.22328215

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	4.46705945
2	Phototransduction_Homo sapiens_hsa04744	3.10796338
3	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.09445078
4	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.02308471
5	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.78197929
6	Sulfur metabolism_Homo sapiens_hsa00920	2.49701362
7	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.33028576
8	Fanconi anemia pathway_Homo sapiens_hsa03460	2.27948979
9	Proteasome_Homo sapiens_hsa03050	2.17434330
10	Homologous recombination_Homo sapiens_hsa03440	2.14256531
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.99041135
12	Protein export_Homo sapiens_hsa03060	1.93850154
13	Selenocompound metabolism_Homo sapiens_hsa00450	1.81810951
14	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.67769325
15	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.66526598
16	Basal transcription factors_Homo sapiens_hsa03022	1.64374282
17	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.54182757
18	Legionellosis_Homo sapiens_hsa05134	1.51299372
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.49324141
20	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.48159322
21	Type I diabetes mellitus_Homo sapiens_hsa04940	1.47112321
22	Glutathione metabolism_Homo sapiens_hsa00480	1.46699383
23	RNA polymerase_Homo sapiens_hsa03020	1.41987717
24	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.41727631
25	Retinol metabolism_Homo sapiens_hsa00830	1.39662652
26	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.31871159
27	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.31308722
28	Butanoate metabolism_Homo sapiens_hsa00650	1.31041866
29	Steroid biosynthesis_Homo sapiens_hsa00100	1.29116589
30	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.25577957
31	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.23084499
32	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.23079036
33	Taste transduction_Homo sapiens_hsa04742	1.22002162
34	Cocaine addiction_Homo sapiens_hsa05030	1.21959600
35	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.19880459
36	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.16327215
37	Chemical carcinogenesis_Homo sapiens_hsa05204	1.16037875
38	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.11270606
39	Caffeine metabolism_Homo sapiens_hsa00232	1.10627620
40	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.08734947
41	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.05859397
42	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.00474965
43	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.98268326
44	Mismatch repair_Homo sapiens_hsa03430	0.97536523
45	Glycerolipid metabolism_Homo sapiens_hsa00561	0.97490158
46	Tryptophan metabolism_Homo sapiens_hsa00380	0.96436719
47	Pyrimidine metabolism_Homo sapiens_hsa00240	0.94990987
48	Purine metabolism_Homo sapiens_hsa00230	0.94673103
49	RNA degradation_Homo sapiens_hsa03018	0.91947264
50	Olfactory transduction_Homo sapiens_hsa04740	0.91539980
51	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.91208280
52	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.86647779
53	Renin-angiotensin system_Homo sapiens_hsa04614	0.84683528
54	One carbon pool by folate_Homo sapiens_hsa00670	0.82448612
55	Sphingolipid metabolism_Homo sapiens_hsa00600	0.82407558
56	Linoleic acid metabolism_Homo sapiens_hsa00591	0.81523342
57	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.81177192
58	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.80523445
59	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.78739831
60	Nitrogen metabolism_Homo sapiens_hsa00910	0.77007939
61	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.75393199
62	Base excision repair_Homo sapiens_hsa03410	0.74624026
63	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.72502828
64	Fatty acid metabolism_Homo sapiens_hsa01212	0.71218711
65	Propanoate metabolism_Homo sapiens_hsa00640	0.69563304
66	GABAergic synapse_Homo sapiens_hsa04727	0.67981526
67	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.66935401
68	RNA transport_Homo sapiens_hsa03013	0.66657476
69	Fatty acid elongation_Homo sapiens_hsa00062	0.65892697
70	Morphine addiction_Homo sapiens_hsa05032	0.65264942
71	Nucleotide excision repair_Homo sapiens_hsa03420	0.65003704
72	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.64152730
73	Vibrio cholerae infection_Homo sapiens_hsa05110	0.60613016
74	Antigen processing and presentation_Homo sapiens_hsa04612	0.59279311
75	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.57860189
76	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.56411014
77	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.56138601
78	Folate biosynthesis_Homo sapiens_hsa00790	0.55966541
79	Primary immunodeficiency_Homo sapiens_hsa05340	0.54901115
80	Renin secretion_Homo sapiens_hsa04924	0.54758737
81	Serotonergic synapse_Homo sapiens_hsa04726	0.51656016
82	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.50217609
83	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.50214766
84	Salivary secretion_Homo sapiens_hsa04970	0.50057489
85	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.49615039
86	Collecting duct acid secretion_Homo sapiens_hsa04966	0.49120250
87	Regulation of autophagy_Homo sapiens_hsa04140	0.48502832
88	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.47804724
89	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.46568045
90	Non-homologous end-joining_Homo sapiens_hsa03450	0.46399271
91	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.42510083
92	Metabolic pathways_Homo sapiens_hsa01100	0.42220745
93	Rheumatoid arthritis_Homo sapiens_hsa05323	0.41911315
94	Lysosome_Homo sapiens_hsa04142	0.41882605
95	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.40938559
96	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.40202341
97	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.39574027
98	p53 signaling pathway_Homo sapiens_hsa04115	0.36551552
99	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.34201933
100	Nicotine addiction_Homo sapiens_hsa05033	0.31781185

SNX19P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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