SNX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the sorting nexin family whose members contain the phosphoinositide-binding phox (PX) domain. The encoded protein is a component of the retromer complex which plays a role in protein sorting in the endocytic pathway. This protein may form oligomeric complexes with other family members. Alternate splicing results in multiple transcript variants of this gene. Pseudogenes associated with this gene are located on chromosomes 1 and 7. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosome assembly (GO:0042255)4.01764807
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.95909957
3Arp2/3 complex-mediated actin nucleation (GO:0034314)3.93562839
4positive regulation of interferon-alpha production (GO:0032727)3.92925637
5immunoglobulin mediated immune response (GO:0016064)3.85498555
6antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.75187632
7regulation of interferon-alpha production (GO:0032647)3.72382195
8cullin deneddylation (GO:0010388)3.71133798
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.65018784
10neutrophil activation involved in immune response (GO:0002283)3.60012973
11respiratory chain complex IV assembly (GO:0008535)3.58154224
12platelet dense granule organization (GO:0060155)3.53201745
13regulation of interferon-beta biosynthetic process (GO:0045357)3.47224929
14protein deneddylation (GO:0000338)3.46548854
15B cell mediated immunity (GO:0019724)3.44628083
16negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.41659675
17interferon-gamma secretion (GO:0072643)3.38641818
18positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.36172833
19DNA double-strand break processing (GO:0000729)3.33830537
20formation of translation preinitiation complex (GO:0001731)3.28944128
21regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.26402633
22CENP-A containing nucleosome assembly (GO:0034080)3.25998484
23positive regulation by organism of defense response of other organism involved in symbiotic interact3.24541011
24modulation by symbiont of host immune response (GO:0052553)3.24541011
25positive regulation by symbiont of host defense response (GO:0052509)3.24541011
26modulation by symbiont of host defense response (GO:0052031)3.24541011
27modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.24541011
28modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.24541011
29proteasome assembly (GO:0043248)3.24262172
30anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.23086500
31antigen processing and presentation of endogenous antigen (GO:0019883)3.21687184
32amino sugar catabolic process (GO:0046348)3.21178205
33regulation of B cell receptor signaling pathway (GO:0050855)3.19238149
34protein neddylation (GO:0045116)3.15570812
35DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.14427583
36chromatin remodeling at centromere (GO:0031055)3.12410992
37positive regulation of interferon-beta production (GO:0032728)3.09630602
38signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.09109413
39intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.09109413
40signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.08593670
41signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.08593670
42signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.08593670
43RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.07837446
44antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.06525220
45DNA ligation (GO:0006266)3.06283217
46pinocytosis (GO:0006907)3.06047971
47lactate metabolic process (GO:0006089)3.05334265
48signal transduction involved in DNA integrity checkpoint (GO:0072401)3.04028128
49signal transduction involved in DNA damage checkpoint (GO:0072422)3.04028128
50DNA catabolic process, exonucleolytic (GO:0000738)3.03973910
51cytochrome complex assembly (GO:0017004)3.03930188
52exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.03048859
53natural killer cell mediated immunity (GO:0002228)3.02640954
54natural killer cell mediated cytotoxicity (GO:0042267)3.02640954
55negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.02038495
56negative regulation of ligase activity (GO:0051352)3.02038495
57regulation of cellular amino acid metabolic process (GO:0006521)2.99976119
58signal transduction involved in cell cycle checkpoint (GO:0072395)2.96846279
59B cell receptor signaling pathway (GO:0050853)2.94504682
60nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.93831785
61negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.93078141
62rRNA modification (GO:0000154)2.90636020
63positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.89928801
64purine nucleobase biosynthetic process (GO:0009113)2.87073733
65actin nucleation (GO:0045010)2.83764548
66mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.83340586
67respiratory burst (GO:0045730)2.83010662
68negative regulation of protein ubiquitination (GO:0031397)2.82997326
69regulation of ligase activity (GO:0051340)2.81264139
70negative regulation of DNA-dependent DNA replication (GO:2000104)2.80992823
71positive regulation of B cell differentiation (GO:0045579)2.79992590
72hepatocyte apoptotic process (GO:0097284)2.79788253
73cellular response to interferon-alpha (GO:0035457)2.78998965
74antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.78599249
75antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.78599249
76histone mRNA metabolic process (GO:0008334)2.76605632
77transcription from mitochondrial promoter (GO:0006390)2.75426742
78somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.75413715
79somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.75413715
80isotype switching (GO:0045190)2.75413715
81positive regulation of ligase activity (GO:0051351)2.73395227
82histone exchange (GO:0043486)2.73219214
83branched-chain amino acid catabolic process (GO:0009083)2.71675802
84regulation of RIG-I signaling pathway (GO:0039535)2.71074837
85negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.69842127
86metaphase plate congression (GO:0051310)2.69445507
87establishment of protein localization to mitochondrial membrane (GO:0090151)2.68535301
88regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.68125564
89regulation of mitotic spindle checkpoint (GO:1903504)2.68125564
90regulation of translation in response to stress (GO:0043555)2.68071025
91nucleobase biosynthetic process (GO:0046112)2.67731190
92cellular response to interferon-beta (GO:0035458)2.67399221
93folic acid transport (GO:0015884)2.67149277
94type I interferon signaling pathway (GO:0060337)2.67098015
95cellular response to type I interferon (GO:0071357)2.67098015
96mitochondrial DNA replication (GO:0006264)2.66127623
97RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.65751074
98tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.65751074
99cell wall macromolecule catabolic process (GO:0016998)2.65052854
100regulation of interferon-beta production (GO:0032648)2.63932075
101response to type I interferon (GO:0034340)2.63468998
102rRNA methylation (GO:0031167)2.63023321
103positive regulation of cell cycle arrest (GO:0071158)2.62787721
104telomere maintenance via recombination (GO:0000722)2.62644588
105regulation of B cell differentiation (GO:0045577)2.62014116
106negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.61812416
107response to hydroperoxide (GO:0033194)2.58713271
108response to peptidoglycan (GO:0032494)2.58100662
109mitochondrial RNA metabolic process (GO:0000959)2.58055129
110IMP biosynthetic process (GO:0006188)2.58013121
111regulation of cellular amine metabolic process (GO:0033238)2.57467638
112response to interferon-alpha (GO:0035455)2.56901352
113regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.55114069
114DNA strand elongation involved in DNA replication (GO:0006271)2.54812652
115lymphocyte mediated immunity (GO:0002449)2.54434570
116positive regulation of gamma-delta T cell activation (GO:0046645)2.53786465
117tricarboxylic acid cycle (GO:0006099)2.53596498
118purine-containing compound salvage (GO:0043101)2.53066930
119telomere maintenance via semi-conservative replication (GO:0032201)2.52637749
120regulation of helicase activity (GO:0051095)2.52104278
121response to protozoan (GO:0001562)2.51427634
122interferon-gamma-mediated signaling pathway (GO:0060333)2.51140514
123protein complex biogenesis (GO:0070271)2.49589248
124L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.49207330
125establishment of integrated proviral latency (GO:0075713)2.49194406
126macrophage activation involved in immune response (GO:0002281)2.48746140
127establishment of chromosome localization (GO:0051303)2.44655453
128mitochondrial respiratory chain complex assembly (GO:0033108)2.44139292
129regulation of meiosis I (GO:0060631)2.43992254
130defense response to protozoan (GO:0042832)2.42868909
131regulation of ubiquitin-protein transferase activity (GO:0051438)2.42841680
132negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.42794447
133mitotic recombination (GO:0006312)2.42651618
134cyclooxygenase pathway (GO:0019371)2.42284587
135cellular response to zinc ion (GO:0071294)2.42042197
136folic acid metabolic process (GO:0046655)2.41937695
137protein K11-linked ubiquitination (GO:0070979)2.41848753
138mitotic metaphase plate congression (GO:0007080)2.41304194
139response to interferon-beta (GO:0035456)2.41266026
140positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.40870353
141DNA strand elongation (GO:0022616)2.40857301
142mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.40216592
143mitotic spindle checkpoint (GO:0071174)2.40050940
144chaperone mediated protein folding requiring cofactor (GO:0051085)2.39573423
145signal transduction in response to DNA damage (GO:0042770)2.39011394
146DNA deamination (GO:0045006)2.39010842
147neutrophil activation (GO:0042119)2.38994644
148DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.38691834
149spindle checkpoint (GO:0031577)2.38457891
150mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.38142355
151mitochondrial respiratory chain complex I assembly (GO:0032981)2.38142355
152NADH dehydrogenase complex assembly (GO:0010257)2.38142355
153production of molecular mediator involved in inflammatory response (GO:0002532)2.38095599
154N-acetylneuraminate metabolic process (GO:0006054)2.37497923
155positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.37483523
156positive regulation of mast cell activation involved in immune response (GO:0033008)2.36113979
157positive regulation of mast cell degranulation (GO:0043306)2.36113979
158positive regulation of antigen processing and presentation (GO:0002579)2.35755296
159G1/S transition of mitotic cell cycle (GO:0000082)2.35307755
160cell cycle G1/S phase transition (GO:0044843)2.35307755
161oxidative phosphorylation (GO:0006119)2.33655755
162positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.33515805
163protein localization to kinetochore (GO:0034501)2.33000593
164histone-serine phosphorylation (GO:0035404)2.32838047
165leukocyte mediated cytotoxicity (GO:0001909)2.32557739
166DNA replication checkpoint (GO:0000076)2.32146012
167regulation of histone H3-K27 methylation (GO:0061085)2.31414569
168histamine secretion (GO:0001821)2.31359261
169regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.31199403

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.33713193
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.13315322
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.87938591
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.81573262
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.76373486
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.56863065
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.53256967
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.50338606
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.49476645
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.46290673
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.43338171
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.41299659
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.39734069
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.27515830
15SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.25108724
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.24898227
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.19617511
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.18368336
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.15919247
20IRF8_27001747_Chip-Seq_BMDM_Mouse2.10009060
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.05641583
22VDR_23849224_ChIP-Seq_CD4+_Human1.98961170
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.95364476
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.93645250
25* SPI1_23547873_ChIP-Seq_NB4_Human1.88911501
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.84704640
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.84692681
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.84194228
29MYC_19030024_ChIP-ChIP_MESCs_Mouse1.84151704
30CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.83912652
31NELFA_20434984_ChIP-Seq_ESCs_Mouse1.81775797
32* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.80748684
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.78202330
34* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74802795
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.74023078
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.73547170
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.70327134
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.69526039
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.69467304
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.67846378
41ELK1_19687146_ChIP-ChIP_HELA_Human1.66859146
42* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65073005
43* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.62857909
44STAT4_19710469_ChIP-ChIP_TH1__Mouse1.60416097
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60093203
46AR_21909140_ChIP-Seq_LNCAP_Human1.59404559
47EWS_26573619_Chip-Seq_HEK293_Human1.55476123
48VDR_22108803_ChIP-Seq_LS180_Human1.55422796
49DCP1A_22483619_ChIP-Seq_HELA_Human1.54306761
50FOXP3_21729870_ChIP-Seq_TREG_Human1.53487260
51* TFEB_21752829_ChIP-Seq_HELA_Human1.50610025
52SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.49774538
53HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.47131915
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.46109310
55BP1_19119308_ChIP-ChIP_Hs578T_Human1.45332400
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42819761
57MYC_22102868_ChIP-Seq_BL_Human1.42805368
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39816975
59FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.39762066
60XRN2_22483619_ChIP-Seq_HELA_Human1.39601060
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38652770
62MYB_26560356_Chip-Seq_TH2_Human1.37779562
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37366400
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.36717339
65* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35121009
66GABP_19822575_ChIP-Seq_HepG2_Human1.34953368
67* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.34549920
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.34147020
69STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.33909941
70POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.32474558
71MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.29898594
72TAF15_26573619_Chip-Seq_HEK293_Human1.28954240
73STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.26573274
74MYB_26560356_Chip-Seq_TH1_Human1.25469055
75STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25391096
76ZNF274_21170338_ChIP-Seq_K562_Hela1.25374592
77CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24778493
78KDM5A_27292631_Chip-Seq_BREAST_Human1.23529182
79FUS_26573619_Chip-Seq_HEK293_Human1.23386673
80STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.23144240
81* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.22635536
82E2F1_21310950_ChIP-Seq_MCF-7_Human1.21837653
83CIITA_25753668_ChIP-Seq_RAJI_Human1.20932260
84BRD4_27068464_Chip-Seq_AML-cells_Mouse1.19877259
85NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.18599153
86SALL4_22934838_ChIP-ChIP_CD34+_Human1.18443520
87PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.18225938
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.18115961
89RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.18018791
90HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15981462
91MAF_26560356_Chip-Seq_TH1_Human1.13408188
92VDR_21846776_ChIP-Seq_THP-1_Human1.12994609
93RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.12653177
94HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.11948193
95MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10940574
96TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.10768536
97PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07100572
98Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06463879
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05202727
100* P300_19829295_ChIP-Seq_ESCs_Human1.04442053
101MYC_18940864_ChIP-ChIP_HL60_Human1.04000511
102TTF2_22483619_ChIP-Seq_HELA_Human1.03736301
103RUNX1_22412390_ChIP-Seq_EML_Mouse1.03501074
104ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03428420
105EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02573144
106EZH2_27294783_Chip-Seq_NPCs_Mouse1.01067891
107SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.00683717
108GATA3_26560356_Chip-Seq_TH2_Human1.00276373
109YY1_21170310_ChIP-Seq_MESCs_Mouse1.00034456
110PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99045032
111ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98802558
112GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98702593
113CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98163341
114NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.97854835
115CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97643908
116NANOG_19829295_ChIP-Seq_ESCs_Human0.97352615
117SOX2_19829295_ChIP-Seq_ESCs_Human0.97352615
118IGF1R_20145208_ChIP-Seq_DFB_Human0.96680790
119SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95372250
120RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94932385
121CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94883968
122THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94778668
123GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93887064
124PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92725749
125ELK1_22589737_ChIP-Seq_MCF10A_Human0.92557522
126* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92548586
127YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92246408
128NFE2_27457419_Chip-Seq_LIVER_Mouse0.88025472
129* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.84163079
130SUZ12_27294783_Chip-Seq_NPCs_Mouse0.83914302
131ELF5_23300383_ChIP-Seq_T47D_Human0.83760284
132* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.83224660
133HTT_18923047_ChIP-ChIP_STHdh_Human0.83011202
134AR_20517297_ChIP-Seq_VCAP_Human0.82459602
135CRX_20693478_ChIP-Seq_RETINA_Mouse0.81621241
136RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.81413546

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.05553663
2MP0003693_abnormal_embryo_hatching3.47669903
3MP0009785_altered_susceptibility_to2.80290302
4MP0005058_abnormal_lysosome_morphology2.77811354
5MP0001800_abnormal_humoral_immune2.62964366
6MP0002148_abnormal_hypersensitivity_rea2.57762818
7MP0005671_abnormal_response_to2.52229381
8MP0002452_abnormal_antigen_presenting2.49022847
9MP0005000_abnormal_immune_tolerance2.48194088
10MP0004957_abnormal_blastocyst_morpholog2.46322083
11MP0001790_abnormal_immune_system2.45267160
12MP0005387_immune_system_phenotype2.45267160
13MP0003436_decreased_susceptibility_to2.42359539
14MP0000685_abnormal_immune_system2.37755811
15MP0009840_abnormal_foam_cell2.31362037
16MP0002419_abnormal_innate_immunity2.25322627
17MP0005025_abnormal_response_to2.20348505
18MP0002723_abnormal_immune_serum2.19729789
19MP0003111_abnormal_nucleus_morphology2.17860417
20MP0001819_abnormal_immune_cell2.11753519
21MP0002420_abnormal_adaptive_immunity2.11427211
22MP0009697_abnormal_copulation1.99370617
23MP0006082_CNS_inflammation1.98509306
24MP0003077_abnormal_cell_cycle1.97951719
25MP0002396_abnormal_hematopoietic_system1.97042980
26MP0005075_abnormal_melanosome_morpholog1.93637499
27MP0010094_abnormal_chromosome_stability1.93635378
28MP0000516_abnormal_urinary_system1.90920481
29MP0005367_renal/urinary_system_phenotyp1.90920481
30MP0010352_gastrointestinal_tract_polyps1.89606558
31MP0009333_abnormal_splenocyte_physiolog1.88024260
32MP0002398_abnormal_bone_marrow1.84410591
33MP0008877_abnormal_DNA_methylation1.83376396
34MP0000372_irregular_coat_pigmentation1.75224308
35MP0006036_abnormal_mitochondrial_physio1.74862175
36MP0000716_abnormal_immune_system1.74315881
37MP0000689_abnormal_spleen_morphology1.72045100
38MP0003303_peritoneal_inflammation1.68813155
39MP0003724_increased_susceptibility_to1.62965793
40MP0002722_abnormal_immune_system1.61100023
41MP0002405_respiratory_system_inflammati1.59002769
42MP0001764_abnormal_homeostasis1.58747104
43MP0002138_abnormal_hepatobiliary_system1.57489159
44MP0001853_heart_inflammation1.56292440
45MP0005464_abnormal_platelet_physiology1.55123200
46MP0002429_abnormal_blood_cell1.54565579
47MP0001845_abnormal_inflammatory_respons1.54456489
48MP0000569_abnormal_digit_pigmentation1.52290477
49MP0004947_skin_inflammation1.46864565
50MP0001533_abnormal_skeleton_physiology1.46241037
51MP0005084_abnormal_gallbladder_morpholo1.44853338
52MP0003172_abnormal_lysosome_physiology1.44680122
53MP0008057_abnormal_DNA_replication1.44041412
54MP0010307_abnormal_tumor_latency1.43032331
55MP0008007_abnormal_cellular_replicative1.41989218
56MP0008058_abnormal_DNA_repair1.41594392
57MP0003191_abnormal_cellular_cholesterol1.40780812
58MP0003448_altered_tumor_morphology1.39820133
59MP0003763_abnormal_thymus_physiology1.39746869
60MP0002102_abnormal_ear_morphology1.39128762
61MP0010155_abnormal_intestine_physiology1.38687193
62MP0004147_increased_porphyrin_level1.37479030
63MP0006035_abnormal_mitochondrial_morpho1.34933144
64MP0004808_abnormal_hematopoietic_stem1.33470885
65MP0008260_abnormal_autophagy1.32762483
66MP0003566_abnormal_cell_adhesion1.32590330
67MP0003186_abnormal_redox_activity1.29778274
68MP0008004_abnormal_stomach_pH1.29015081
69MP0006072_abnormal_retinal_apoptosis1.28671730
70MP0008469_abnormal_protein_level1.28154479
71MP0000490_abnormal_crypts_of1.27346029
72MP0006054_spinal_hemorrhage1.25991353
73MP0001545_abnormal_hematopoietic_system1.25208591
74MP0005397_hematopoietic_system_phenotyp1.25208591
75MP0000858_altered_metastatic_potential1.23679297
76MP0002166_altered_tumor_susceptibility1.21138794
77MP0003567_abnormal_fetal_cardiomyocyte1.20707672
78MP0002006_tumorigenesis1.18991190
79MP0002019_abnormal_tumor_incidence1.15609107
80MP0002837_dystrophic_cardiac_calcinosis1.15233123
81MP0005310_abnormal_salivary_gland1.13397621
82MP0005023_abnormal_wound_healing1.12042947
83MP0004782_abnormal_surfactant_physiolog1.11581241
84MP0008932_abnormal_embryonic_tissue1.09452067
85MP0000343_altered_response_to1.08433847
86MP0005253_abnormal_eye_physiology1.07949211
87MP0000703_abnormal_thymus_morphology1.07269656
88MP0005174_abnormal_tail_pigmentation1.07196041
89MP0001542_abnormal_bone_strength1.05517161
90MP0000647_abnormal_sebaceous_gland1.03772496
91MP0003718_maternal_effect1.03350111
92MP0002090_abnormal_vision1.02045262
93MP0001730_embryonic_growth_arrest1.00658811
94MP0000350_abnormal_cell_proliferation0.98150070
95MP0003866_abnormal_defecation0.96513797
96MP0004510_myositis0.96457467
97MP0003075_altered_response_to0.95195758
98MP0003806_abnormal_nucleotide_metabolis0.94687334
99MP0002139_abnormal_hepatobiliary_system0.92329130
100MP0002132_abnormal_respiratory_system0.88990842
101MP0003705_abnormal_hypodermis_morpholog0.88128014
102MP0000313_abnormal_cell_death0.85941920
103MP0002136_abnormal_kidney_physiology0.85558795
104MP0003195_calcinosis0.84367506
105MP0004215_abnormal_myocardial_fiber0.82966560
106MP0009278_abnormal_bone_marrow0.82351140
107MP0000465_gastrointestinal_hemorrhage0.82189868
108MP0000427_abnormal_hair_cycle0.81496354
109MP0002095_abnormal_skin_pigmentation0.80723741
110MP0005332_abnormal_amino_acid0.79944624
111MP0002933_joint_inflammation0.78829223
112MP0001727_abnormal_embryo_implantation0.78008718
113MP0000358_abnormal_cell_content/0.77099582
114MP0003828_pulmonary_edema0.76867449
115MP0005076_abnormal_cell_differentiation0.76728535
116MP0001324_abnormal_eye_pigmentation0.76611060
117MP0001756_abnormal_urination0.76563791
118MP0010234_abnormal_vibrissa_follicle0.75892932
119MP0008873_increased_physiological_sensi0.75306235
120MP0008438_abnormal_cutaneous_collagen0.75143174
121MP0009764_decreased_sensitivity_to0.74747738
122MP0003011_delayed_dark_adaptation0.74515493
123MP0005636_abnormal_mineral_homeostasis0.72260472
124MP0005085_abnormal_gallbladder_physiolo0.71982439
125MP0002998_abnormal_bone_remodeling0.71865838
126MP0000015_abnormal_ear_pigmentation0.71182822
127MP0003300_gastrointestinal_ulcer0.69826427
128MP0002277_abnormal_respiratory_mucosa0.68837373
129MP0009763_increased_sensitivity_to0.68147422
130MP0005621_abnormal_cell_physiology0.67947341
131MP0003786_premature_aging0.67905172
132MP0005390_skeleton_phenotype0.67588203
133MP0005166_decreased_susceptibility_to0.65226584
134MP0009643_abnormal_urine_homeostasis0.65062437
135MP0000598_abnormal_liver_morphology0.63578622
136MP0005395_other_phenotype0.63547771

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.32184928
2Eczematoid dermatitis (HP:0000976)4.95822612
3Recurrent bacterial skin infections (HP:0005406)4.73027970
4Vacuolated lymphocytes (HP:0001922)4.11868264
5Abnormality of macrophages (HP:0004311)3.78588804
6Systemic lupus erythematosus (HP:0002725)3.75509263
7Cellulitis (HP:0100658)3.66221237
8Increased cerebral lipofuscin (HP:0011813)3.58141574
9Agammaglobulinemia (HP:0004432)3.45882829
10Abnormality of liposaccharide metabolism (HP:0010968)3.45355624
11Abnormality of glycosphingolipid metabolism (HP:0004343)3.45355624
12Abnormality of glycolipid metabolism (HP:0010969)3.45355624
13Poor head control (HP:0002421)3.43806153
14Increased neuronal autofluorescent lipopigment (HP:0002074)3.42032626
15Acute necrotizing encephalopathy (HP:0006965)3.40940135
16Recurrent gram-negative bacterial infections (HP:0005420)3.37059038
17IgM deficiency (HP:0002850)3.27314182
18Autoimmune thrombocytopenia (HP:0001973)3.26258252
19Increased CSF lactate (HP:0002490)3.25075273
20Progressive macrocephaly (HP:0004481)3.22110093
21Agnosia (HP:0010524)3.14110350
22Pustule (HP:0200039)3.12260368
23Recurrent bronchitis (HP:0002837)3.07912248
24Recurrent pneumonia (HP:0006532)3.06579997
25Recurrent viral infections (HP:0004429)3.05896010
26Mitochondrial inheritance (HP:0001427)3.05441165
27Acute encephalopathy (HP:0006846)3.04813676
28Osteomyelitis (HP:0002754)3.02710971
293-Methylglutaconic aciduria (HP:0003535)2.99830931
30Abnormal mitochondria in muscle tissue (HP:0008316)2.98405783
31Recurrent fungal infections (HP:0002841)2.92767903
32Elevated erythrocyte sedimentation rate (HP:0003565)2.92408259
33Petechiae (HP:0000967)2.88007423
34Hepatocellular necrosis (HP:0001404)2.84655595
35Type I transferrin isoform profile (HP:0003642)2.84317021
36Abnormality of the anterior horn cell (HP:0006802)2.82667653
37Degeneration of anterior horn cells (HP:0002398)2.82667653
38Hepatic necrosis (HP:0002605)2.82077336
39Prolonged neonatal jaundice (HP:0006579)2.81167360
40Microvesicular hepatic steatosis (HP:0001414)2.78654713
41Interstitial pulmonary disease (HP:0006530)2.78146845
42Chronic obstructive pulmonary disease (HP:0006510)2.77079442
43Obstructive lung disease (HP:0006536)2.77079442
44Recurrent lower respiratory tract infections (HP:0002783)2.75287321
45Mediastinal lymphadenopathy (HP:0100721)2.74684961
46Recurrent skin infections (HP:0001581)2.70083512
47Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.65038607
48Abnormality of alanine metabolism (HP:0010916)2.65038607
49Hyperalaninemia (HP:0003348)2.65038607
50Methylmalonic acidemia (HP:0002912)2.62890679
51Myositis (HP:0100614)2.62306601
52Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.60867520
53Abnormal protein N-linked glycosylation (HP:0012347)2.60867520
54Abnormal protein glycosylation (HP:0012346)2.60867520
55Abnormal glycosylation (HP:0012345)2.60867520
56Meningitis (HP:0001287)2.59381200
57Basal ganglia calcification (HP:0002135)2.58762978
58Cerebral edema (HP:0002181)2.58535848
59Vasculitis (HP:0002633)2.55699728
60Abnormality of methionine metabolism (HP:0010901)2.46005097
61Neoplasm of the adrenal gland (HP:0100631)2.45814559
62Eosinophilia (HP:0001880)2.45444209
63Lactic acidosis (HP:0003128)2.44596165
64Increased serum lactate (HP:0002151)2.44090814
65IgG deficiency (HP:0004315)2.43611810
66Reduced antithrombin III activity (HP:0001976)2.43257709
67Increased serum pyruvate (HP:0003542)2.42430423
68Abnormality of T cell physiology (HP:0011840)2.41551569
69Abnormality of the prostate (HP:0008775)2.40765121
70IgA deficiency (HP:0002720)2.40297409
71B lymphocytopenia (HP:0010976)2.40193681
72Abnormality of B cell number (HP:0010975)2.40193681
73Abolished electroretinogram (ERG) (HP:0000550)2.38285455
74Lymphopenia (HP:0001888)2.37262051
75Abnormality of aspartate family amino acid metabolism (HP:0010899)2.37148712
76Abnormality of T cells (HP:0002843)2.36787006
77Granulocytopenia (HP:0001913)2.35892861
78Chronic otitis media (HP:0000389)2.34487583
79Increased hepatocellular lipid droplets (HP:0006565)2.34220934
80Abnormality of cells of the lymphoid lineage (HP:0012140)2.34143299
81Combined immunodeficiency (HP:0005387)2.33848998
82Anorexia (HP:0002039)2.33490054
83Gastrointestinal stroma tumor (HP:0100723)2.32156850
84Respiratory failure (HP:0002878)2.27912600
85Gingivitis (HP:0000230)2.27716009
86Abnormality of eosinophils (HP:0001879)2.26586031
87Lipid accumulation in hepatocytes (HP:0006561)2.24855886
88Panhypogammaglobulinemia (HP:0003139)2.24781181
89Gonadotropin excess (HP:0000837)2.23401224
90Leukocytosis (HP:0001974)2.23016987
91Nausea (HP:0002018)2.22478925
92Osteolytic defects of the hand bones (HP:0009699)2.21681415
93Osteolytic defects of the phalanges of the hand (HP:0009771)2.21681415
94Birth length less than 3rd percentile (HP:0003561)2.21259978
95Lymphoma (HP:0002665)2.20473095
96CNS demyelination (HP:0007305)2.20299794
97Carpal bone hypoplasia (HP:0001498)2.19565163
98Thrombocytosis (HP:0001894)2.17520906
99Hepatosplenomegaly (HP:0001433)2.16822115
100Methylmalonic aciduria (HP:0012120)2.16350282
101Leukopenia (HP:0001882)2.16279404
102Colitis (HP:0002583)2.14975288
103Dysostosis multiplex (HP:0000943)2.14646825
104Decreased activity of mitochondrial respiratory chain (HP:0008972)2.13562367
105Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.13562367
106Abnormality of T cell number (HP:0011839)2.12772895
107Skin ulcer (HP:0200042)2.11406635
108Abnormality of the vasculature of the conjunctiva (HP:0008054)2.08485337
109Prostate neoplasm (HP:0100787)2.07596447
110Periodontitis (HP:0000704)2.07369780
111Orchitis (HP:0100796)2.06023143
112Personality changes (HP:0000751)2.04603438
113T lymphocytopenia (HP:0005403)2.03638192
114Mutism (HP:0002300)2.01520627
115Thyroiditis (HP:0100646)2.01277961
116Exertional dyspnea (HP:0002875)1.99417897
117Abnormality of glycolysis (HP:0004366)1.99260914
118Loss of speech (HP:0002371)1.98691086
119Lethargy (HP:0001254)1.96722976
120Aplastic anemia (HP:0001915)1.96689923
121Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.96656219
122Papilloma (HP:0012740)1.96215678
123Verrucae (HP:0200043)1.96215678
124Glomerulonephritis (HP:0000099)1.96050289
125Small epiphyses (HP:0010585)1.95913973
126Abnormality of serum amino acid levels (HP:0003112)1.95853755
127Posterior subcapsular cataract (HP:0007787)1.95408014
128Spontaneous hematomas (HP:0007420)1.95086800
129Abnormality of the basal ganglia (HP:0002134)1.94921200
130Abnormality of chromosome stability (HP:0003220)1.93533919
131Hypoglycemic coma (HP:0001325)1.93392555
132Renal cortical cysts (HP:0000803)1.93288929
133Severe combined immunodeficiency (HP:0004430)1.92352014
134Sepsis (HP:0100806)1.92011005
135Inflammation of the large intestine (HP:0002037)1.91976822
136Chronic mucocutaneous candidiasis (HP:0002728)1.91772366
137Recurrent cutaneous fungal infections (HP:0011370)1.91772366
138Disinhibition (HP:0000734)1.91659976
139Increased IgM level (HP:0003496)1.91372894
140Decreased electroretinogram (ERG) amplitude (HP:0000654)1.91314070
141Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.91023239
142Neutropenia (HP:0001875)1.90879782
143Mucosal telangiectasiae (HP:0100579)1.90640061
144Breast hypoplasia (HP:0003187)1.90592784
145Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.90455497
146Retrobulbar optic neuritis (HP:0100654)1.89066735
147Optic neuritis (HP:0100653)1.89066735
148Abnormal spermatogenesis (HP:0008669)1.89046305
149Tongue fasciculations (HP:0001308)1.88945792
150Respiratory difficulties (HP:0002880)1.86690716
151Hyperinsulinemic hypoglycemia (HP:0000825)1.86392182
152Amaurosis fugax (HP:0100576)1.86122794
153Nonimmune hydrops fetalis (HP:0001790)1.85991076
154Multiple enchondromatosis (HP:0005701)1.85142388
155Vertebral compression fractures (HP:0002953)1.84844539
156Stomatitis (HP:0010280)1.83868791
157Colon cancer (HP:0003003)1.80774240
158Hematochezia (HP:0002573)1.80666315
159Facial diplegia (HP:0001349)1.80315607
160Volvulus (HP:0002580)1.79673946
161Albinism (HP:0001022)1.78011048
162Constricted visual fields (HP:0001133)1.75886040
163Rhabdomyosarcoma (HP:0002859)1.75765160
164Abnormality of vitamin B metabolism (HP:0004340)1.74797665
165Abnormality of the vitamin B12 metabolism (HP:0004341)1.73215536
166Renal Fanconi syndrome (HP:0001994)1.72833308
167Tubulointerstitial nephritis (HP:0001970)1.72382535
168Palpitations (HP:0001962)1.71216772
169Proximal tubulopathy (HP:0000114)1.70139318
170Dicarboxylic aciduria (HP:0003215)1.69151097
171Abnormality of dicarboxylic acid metabolism (HP:0010995)1.69151097
172Optic disc pallor (HP:0000543)1.68871893
173Symptomatic seizures (HP:0011145)1.68756751
174Congenital, generalized hypertrichosis (HP:0004540)1.66426567
175Breast carcinoma (HP:0003002)1.65625623
176Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.64408229
177Generalized aminoaciduria (HP:0002909)1.64111878
178Leukodystrophy (HP:0002415)1.63409990

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK3.44527392
2BUB13.44296176
3EIF2AK12.96981738
4MAP4K12.84666255
5EPHA22.81538435
6WEE12.76500074
7TRIM282.70091939
8EIF2AK32.45323238
9TYK22.12118785
10NUAK12.08845609
11MAP3K142.03361762
12PIM21.99000558
13VRK21.98975228
14BMPR1B1.95037809
15TESK21.88738590
16TBK11.88047820
17MKNK11.85092646
18ZAP701.84253449
19MST41.79268689
20SIK31.78569346
21NEK91.74876500
22FRK1.74356439
23NME21.72164188
24STK101.69453815
25NEK21.64072950
26IRAK41.63129224
27KDR1.60170092
28STK161.57674183
29IRAK31.56902088
30ARAF1.54227562
31CSF1R1.53777259
32BRSK21.52586590
33PLK21.51133807
34MKNK21.50949208
35GRK11.49496501
36TSSK61.47813821
37CDK191.47272411
38PBK1.45597212
39IKBKB1.43779558
40RPS6KA41.40272520
41ERN11.39998713
42WNK31.36784757
43ACVR1B1.36704485
44SYK1.31268545
45SCYL21.30920987
46KIT1.29122288
47TNIK1.27386533
48TESK11.26707071
49JAK31.26543688
50BTK1.26191386
51NEK11.25885866
52OXSR11.22967416
53TXK1.13783420
54IKBKE1.12537411
55JAK11.11178047
56TGFBR21.11113380
57PIM11.06276542
58ADRBK21.06134206
59LRRK21.03812842
60STK41.03136992
61RIPK41.02826910
62LYN0.99953534
63CDC70.99417616
64TAF10.98905806
65TTK0.97972274
66TEC0.96944352
67RPS6KB20.96268372
68BCR0.93130868
69DAPK10.92501086
70PLK40.91770837
71GRK60.90849499
72MAP3K30.90127405
73MAP3K80.89224113
74MAP4K20.88131771
75NLK0.87524640
76ZAK0.86264789
77MAP3K120.85998994
78EIF2AK20.85889858
79CDK40.83320491
80PASK0.82390341
81PLK10.81709015
82SRPK10.81189473
83HCK0.79089889
84MAP3K110.77767256
85FGFR40.76728400
86AURKB0.76021942
87PAK40.73979378
88MARK30.71983117
89FGR0.71674536
90LCK0.70398465
91TGFBR10.70029252
92CSNK1G10.69747019
93FER0.69684067
94FES0.69280984
95PDK20.68338386
96CSK0.65931165
97MAP2K30.65696323
98CSNK1G30.64475451
99GRK70.64137831
100CHUK0.63611787
101ATR0.63436816
102PRKCD0.62236502
103MAP3K130.62032607
104PLK30.60113560
105BRAF0.58068691
106STK38L0.57683454
107STK390.57020297
108BMPR20.56693697
109TLK10.53103045
110PRKCI0.52665257
111AURKA0.52401319
112BRSK10.51069870
113CCNB10.49622260
114PRKCE0.49471209
115CSNK1G20.49200501
116STK240.48674241
117CDK60.48015847
118MAP3K100.47789335
119YES10.47641276
120MAPKAPK20.46318887
121CAMKK20.46313485
122EGFR0.45982028
123CSNK2A10.45436587
124PAK10.44564635
125VRK10.43878156
126FLT30.43401343
127ITK0.42936670
128EPHA30.42589992
129ATM0.42020528
130BCKDK0.40892064
131STK30.40233960
132ABL10.40222947
133ERBB30.39592225
134IGF1R0.38953699
135MAPKAPK30.37851636
136MATK0.37201842
137CSNK2A20.36256775
138CDK90.35396548
139ALK0.34782895
140CLK10.34758018
141CSNK1A1L0.34273848
142CHEK20.30499059

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.40906001
2DNA replication_Homo sapiens_hsa030302.66884132
3Primary immunodeficiency_Homo sapiens_hsa053402.41933412
4Mismatch repair_Homo sapiens_hsa034302.29618776
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.22088758
6Oxidative phosphorylation_Homo sapiens_hsa001902.18779811
7Antigen processing and presentation_Homo sapiens_hsa046122.17781861
8Legionellosis_Homo sapiens_hsa051342.09587940
9Propanoate metabolism_Homo sapiens_hsa006402.03228456
10Base excision repair_Homo sapiens_hsa034101.96156380
11Lysosome_Homo sapiens_hsa041421.94678341
12Leishmaniasis_Homo sapiens_hsa051401.86085186
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.81847032
14RNA polymerase_Homo sapiens_hsa030201.81598174
15Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.78958375
16Fatty acid elongation_Homo sapiens_hsa000621.76351463
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.75175549
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.71358305
19Other glycan degradation_Homo sapiens_hsa005111.71075046
20Homologous recombination_Homo sapiens_hsa034401.70809257
21Ribosome_Homo sapiens_hsa030101.69704319
22RNA transport_Homo sapiens_hsa030131.69167737
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.66783281
24B cell receptor signaling pathway_Homo sapiens_hsa046621.64501655
25Parkinsons disease_Homo sapiens_hsa050121.61563345
26Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.60252488
27Staphylococcus aureus infection_Homo sapiens_hsa051501.56658220
28Measles_Homo sapiens_hsa051621.54506402
29Nucleotide excision repair_Homo sapiens_hsa034201.53714232
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.51537520
31Pyrimidine metabolism_Homo sapiens_hsa002401.46986035
32Spliceosome_Homo sapiens_hsa030401.44604275
33Epstein-Barr virus infection_Homo sapiens_hsa051691.44033705
34Herpes simplex infection_Homo sapiens_hsa051681.43020315
35Allograft rejection_Homo sapiens_hsa053301.43018651
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.40245651
37Pentose phosphate pathway_Homo sapiens_hsa000301.35611069
38Cell cycle_Homo sapiens_hsa041101.33219390
39Graft-versus-host disease_Homo sapiens_hsa053321.30892621
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29544517
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.29108555
42Tuberculosis_Homo sapiens_hsa051521.29012645
43Shigellosis_Homo sapiens_hsa051311.27499638
44Osteoclast differentiation_Homo sapiens_hsa043801.26211862
45Pertussis_Homo sapiens_hsa051331.24932015
46Non-homologous end-joining_Homo sapiens_hsa034501.24829370
47NOD-like receptor signaling pathway_Homo sapiens_hsa046211.23488759
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20355252
49Influenza A_Homo sapiens_hsa051641.20284834
50Hematopoietic cell lineage_Homo sapiens_hsa046401.18965963
51Glycosaminoglycan degradation_Homo sapiens_hsa005311.18517134
52Regulation of autophagy_Homo sapiens_hsa041401.18172159
53Rheumatoid arthritis_Homo sapiens_hsa053231.17816662
54Cysteine and methionine metabolism_Homo sapiens_hsa002701.16513846
55Sulfur metabolism_Homo sapiens_hsa009201.16232362
56Pyruvate metabolism_Homo sapiens_hsa006201.14418949
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.14127593
58Apoptosis_Homo sapiens_hsa042101.13845193
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.12408779
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11637330
61p53 signaling pathway_Homo sapiens_hsa041151.10797795
62Peroxisome_Homo sapiens_hsa041461.09780409
63Phagosome_Homo sapiens_hsa041451.09169787
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.05233542
65Selenocompound metabolism_Homo sapiens_hsa004501.04436958
66One carbon pool by folate_Homo sapiens_hsa006701.01117230
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00948282
68Malaria_Homo sapiens_hsa051440.97642748
69Huntingtons disease_Homo sapiens_hsa050160.96087671
70Fructose and mannose metabolism_Homo sapiens_hsa000510.95837232
71Steroid biosynthesis_Homo sapiens_hsa001000.88584282
72Toxoplasmosis_Homo sapiens_hsa051450.88178417
73Carbon metabolism_Homo sapiens_hsa012000.85391673
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.85169423
75Asthma_Homo sapiens_hsa053100.85018424
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84288214
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83924196
78Viral carcinogenesis_Homo sapiens_hsa052030.82449403
79Salmonella infection_Homo sapiens_hsa051320.82325296
80Alzheimers disease_Homo sapiens_hsa050100.82254267
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81303879
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81035502
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.80230199
84Viral myocarditis_Homo sapiens_hsa054160.78158353
85Type I diabetes mellitus_Homo sapiens_hsa049400.74943876
86Fanconi anemia pathway_Homo sapiens_hsa034600.74761210
87Hepatitis B_Homo sapiens_hsa051610.72824901
88Protein export_Homo sapiens_hsa030600.72274755
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70089681
90Basal transcription factors_Homo sapiens_hsa030220.69009538
91Folate biosynthesis_Homo sapiens_hsa007900.68302317
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.68039590
93Galactose metabolism_Homo sapiens_hsa000520.67623806
94RNA degradation_Homo sapiens_hsa030180.66673621
95Nitrogen metabolism_Homo sapiens_hsa009100.66124327
96Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65618489
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65417956
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.64503362
99Autoimmune thyroid disease_Homo sapiens_hsa053200.64449214
100Renin-angiotensin system_Homo sapiens_hsa046140.64352951
101beta-Alanine metabolism_Homo sapiens_hsa004100.63384256
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63371286
103TNF signaling pathway_Homo sapiens_hsa046680.62091207
104Tryptophan metabolism_Homo sapiens_hsa003800.62073019
105Hepatitis C_Homo sapiens_hsa051600.60789689
106Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59722955
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59532023
1082-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58390576
109Butanoate metabolism_Homo sapiens_hsa006500.57196230
110Purine metabolism_Homo sapiens_hsa002300.57018265
111HTLV-I infection_Homo sapiens_hsa051660.56900286
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56833293
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54608266
114Systemic lupus erythematosus_Homo sapiens_hsa053220.51831837
115Collecting duct acid secretion_Homo sapiens_hsa049660.51514947
116Fatty acid degradation_Homo sapiens_hsa000710.51430865
117Chemokine signaling pathway_Homo sapiens_hsa040620.49376447
118Vibrio cholerae infection_Homo sapiens_hsa051100.48868218
119Glutathione metabolism_Homo sapiens_hsa004800.48779354
120Metabolic pathways_Homo sapiens_hsa011000.48747130
121Caffeine metabolism_Homo sapiens_hsa002320.46649597
122Sphingolipid metabolism_Homo sapiens_hsa006000.46250758
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46194656
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44995899
125T cell receptor signaling pathway_Homo sapiens_hsa046600.43945439
126Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43944953
127Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42279172
128Oocyte meiosis_Homo sapiens_hsa041140.41390349
129* Endocytosis_Homo sapiens_hsa041440.40849481
130Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40748974
131Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39446096
132Fatty acid metabolism_Homo sapiens_hsa012120.38758699
133Arachidonic acid metabolism_Homo sapiens_hsa005900.37246141
134N-Glycan biosynthesis_Homo sapiens_hsa005100.37069024
135Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35814392
136Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34589367
137Phototransduction_Homo sapiens_hsa047440.28349781

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