SNX20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SNX20 interacts with the cytoplasmic domain of PSGL1 (SELPLG; MIM 600738) and cycles PSGL1 into endosomes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by symbiont of host defense response (GO:0052031)5.05951942
2modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.05951942
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.05951942
4positive regulation by organism of defense response of other organism involved in symbiotic interact5.05951942
5modulation by symbiont of host immune response (GO:0052553)5.05951942
6positive regulation by symbiont of host defense response (GO:0052509)5.05951942
7positive regulation of gamma-delta T cell activation (GO:0046645)5.02820303
8antigen processing and presentation of endogenous antigen (GO:0019883)4.99638943
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.97469274
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.95681097
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.95681097
12response to peptidoglycan (GO:0032494)4.70530996
13regulation of interferon-beta biosynthetic process (GO:0045357)4.58840218
14neutrophil activation involved in immune response (GO:0002283)4.47674386
15regulation of B cell receptor signaling pathway (GO:0050855)4.46692026
16immunoglobulin mediated immune response (GO:0016064)4.31836745
17detection of other organism (GO:0098543)4.24907450
18positive regulation of interferon-alpha production (GO:0032727)4.24219470
19response to interleukin-15 (GO:0070672)4.21613737
20response to muramyl dipeptide (GO:0032495)4.20478593
21NIK/NF-kappaB signaling (GO:0038061)4.17665834
22detection of bacterium (GO:0016045)4.16854642
23respiratory burst (GO:0045730)4.15877651
24regulation of interferon-alpha production (GO:0032647)4.10401459
25activated T cell proliferation (GO:0050798)4.05700132
26cellular response to interleukin-15 (GO:0071350)4.03622369
27positive regulation of antigen processing and presentation (GO:0002579)4.00450160
28negative regulation of lymphocyte mediated immunity (GO:0002707)3.99811585
29leukocyte aggregation (GO:0070486)3.94668546
30negative regulation of T cell mediated immunity (GO:0002710)3.85656674
31positive regulation of B cell differentiation (GO:0045579)3.82979678
32neutrophil activation (GO:0042119)3.79701508
33macrophage activation involved in immune response (GO:0002281)3.79165807
34regulation of interleukin-12 biosynthetic process (GO:0045075)3.77141342
35positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.67812004
36granulocyte activation (GO:0036230)3.67433839
37regulation of B cell differentiation (GO:0045577)3.64297927
38B cell receptor signaling pathway (GO:0050853)3.59801442
39negative regulation of leukocyte mediated immunity (GO:0002704)3.59408295
40response to type I interferon (GO:0034340)3.58485336
41defense response to protozoan (GO:0042832)3.58295637
42interferon-gamma-mediated signaling pathway (GO:0060333)3.56913615
43type I interferon signaling pathway (GO:0060337)3.56106031
44cellular response to type I interferon (GO:0071357)3.56106031
45regulation of T cell tolerance induction (GO:0002664)3.54904293
46regulation of dendritic cell antigen processing and presentation (GO:0002604)3.54229671
47regulation of antigen processing and presentation (GO:0002577)3.50492242
48detection of external biotic stimulus (GO:0098581)3.50464213
49response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.50342019
50response to host immune response (GO:0052572)3.50342019
51myeloid dendritic cell activation (GO:0001773)3.47212874
52regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.45259842
53lipopolysaccharide-mediated signaling pathway (GO:0031663)3.44911286
54T cell migration (GO:0072678)3.44587205
55regulation of regulatory T cell differentiation (GO:0045589)3.41961550
56regulation of T cell mediated cytotoxicity (GO:0001914)3.40433362
57negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.37359935
58negative regulation of cell killing (GO:0031342)3.37359935
59regulation of gamma-delta T cell activation (GO:0046643)3.37354916
60negative regulation of interleukin-12 production (GO:0032695)3.37022661
61germinal center formation (GO:0002467)3.35939751
62regulation of tolerance induction (GO:0002643)3.35931921
63cellular extravasation (GO:0045123)3.35331928
64myeloid dendritic cell differentiation (GO:0043011)3.33543717
65mature B cell differentiation (GO:0002335)3.33435926
66regulation of natural killer cell mediated immunity (GO:0002715)3.31300202
67regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.31300202
68positive regulation of T cell mediated cytotoxicity (GO:0001916)3.30984802
69negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.30681194
70positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.28554276
71myeloid cell activation involved in immune response (GO:0002275)3.26701758
72response to protozoan (GO:0001562)3.26429430
73B cell mediated immunity (GO:0019724)3.25688116
74regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.24699232
75positive regulation of interferon-beta production (GO:0032728)3.23799447
76T cell selection (GO:0045058)3.23209545
77positive T cell selection (GO:0043368)3.20703160
78detection of biotic stimulus (GO:0009595)3.18227682
79detection of molecule of bacterial origin (GO:0032490)3.16902373
80response to host (GO:0075136)3.15434317
81response to host defenses (GO:0052200)3.15434317
82response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.15434317
83cellular response to zinc ion (GO:0071294)3.14693680
84superoxide anion generation (GO:0042554)3.14645600
85leukocyte degranulation (GO:0043299)3.11023205
86positive regulation of chemokine biosynthetic process (GO:0045080)3.10137368
87mast cell activation (GO:0045576)3.09725617
88regulation of gamma-delta T cell differentiation (GO:0045586)3.08939239
89B cell homeostasis (GO:0001782)3.07250968
90tolerance induction (GO:0002507)3.05170407
91negative regulation of innate immune response (GO:0045824)3.04025150
92regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.03918705
93natural killer cell mediated immunity (GO:0002228)3.03383729
94natural killer cell mediated cytotoxicity (GO:0042267)3.03383729
95thymic T cell selection (GO:0045061)2.99752951
96regulation of leukocyte mediated cytotoxicity (GO:0001910)2.99575831
97positive regulation of interleukin-12 production (GO:0032735)2.98995268
98dendritic cell chemotaxis (GO:0002407)2.98133682
99regulation of mast cell degranulation (GO:0043304)2.97777524
100Arp2/3 complex-mediated actin nucleation (GO:0034314)2.97469437
101positive regulation of tolerance induction (GO:0002645)2.97302880
102negative regulation of T-helper cell differentiation (GO:0045623)2.95720342
103negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.95720342
104negative regulation of cytokine production involved in immune response (GO:0002719)2.94319399
105negative thymic T cell selection (GO:0045060)2.93021218
106leukocyte migration involved in inflammatory response (GO:0002523)2.91979481
107positive thymic T cell selection (GO:0045059)2.90997784
108negative T cell selection (GO:0043383)2.87675996
109leukocyte cell-cell adhesion (GO:0007159)2.87477728
110negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.87443988
111neutrophil mediated immunity (GO:0002446)2.87182206
112antigen receptor-mediated signaling pathway (GO:0050851)2.86336504
113regulation of mast cell activation (GO:0033003)2.85694829
114regulation of alpha-beta T cell proliferation (GO:0046640)2.84736482
115regulation of interleukin-12 production (GO:0032655)2.83086643
116I-kappaB phosphorylation (GO:0007252)2.82659674
117myeloid leukocyte activation (GO:0002274)2.81673161
118interferon-gamma production (GO:0032609)2.79530340
119positive regulation of mast cell activation (GO:0033005)2.78333251
120positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.77682864
121microglial cell activation (GO:0001774)2.77351736
122cellular response to virus (GO:0098586)2.77060956
123positive regulation of cytokine biosynthetic process (GO:0042108)2.76501205
124antigen processing and presentation via MHC class Ib (GO:0002475)2.76325162
125cellular response to interferon-beta (GO:0035458)2.75490721
126positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.74942001
127regulation of mast cell activation involved in immune response (GO:0033006)2.74707480
128positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.73499749
129regulation of type I interferon-mediated signaling pathway (GO:0060338)2.71262126
130dendritic cell differentiation (GO:0097028)2.70651222
131macrophage activation (GO:0042116)2.70594724
132positive regulation of mast cell degranulation (GO:0043306)2.70574356
133positive regulation of mast cell activation involved in immune response (GO:0033008)2.70574356
134negative regulation of phagocytosis (GO:0050765)2.70344121

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.54961359
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.82250227
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.51765862
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.50733215
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.29072167
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.10588519
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.93175940
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.89386882
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.83023683
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.72034823
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.38178881
12* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.15764574
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.08023047
14EGR1_19374776_ChIP-ChIP_THP-1_Human3.03686885
15MYB_21317192_ChIP-Seq_ERMYB_Mouse3.00343781
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.94524051
17SCL_19346495_ChIP-Seq_HPC-7_Human2.67803138
18SPI1_23547873_ChIP-Seq_NB4_Human2.58095699
19E2F7_22180533_ChIP-Seq_HELA_Human2.49863527
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.48186463
21VDR_21846776_ChIP-Seq_THP-1_Human2.42923903
22* MYB_26560356_Chip-Seq_TH2_Human2.40393865
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.38364629
24RUNX_20019798_ChIP-Seq_JUKART_Human2.38085215
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.32503682
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.31673228
27VDR_24763502_ChIP-Seq_THP-1_Human2.23399478
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.21788364
29* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.19122163
30MAF_26560356_Chip-Seq_TH1_Human2.15350099
31* MYB_26560356_Chip-Seq_TH1_Human2.09798177
32RUNX1_22412390_ChIP-Seq_EML_Mouse2.08094110
33MYC_22102868_ChIP-Seq_BL_Human2.02372616
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.96542745
35* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.92708686
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.87622360
37SPI1_23127762_ChIP-Seq_K562_Human1.85565814
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.83189466
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.79995451
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.78952003
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.77288571
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.75679420
43* UTX_26944678_Chip-Seq_JUKART_Human1.72662376
44PU_27001747_Chip-Seq_BMDM_Mouse1.70580871
45PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.64639275
46LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.57411471
47* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.56366536
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.53093386
49TCF7_22412390_ChIP-Seq_EML_Mouse1.49145904
50GATA2_22383799_ChIP-Seq_G1ME_Mouse1.47838219
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.44099734
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.41318072
53VDR_24787735_ChIP-Seq_THP-1_Human1.39444277
54GATA3_27048872_Chip-Seq_THYMUS_Human1.38936810
55* MAF_26560356_Chip-Seq_TH2_Human1.35318833
56* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35196372
57LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.34272860
58PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31120863
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29559005
60SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21653004
61STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17852481
62GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.16552914
63* GATA3_26560356_Chip-Seq_TH2_Human1.16515324
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16239333
65CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15048185
66BCL6_27268052_Chip-Seq_Bcells_Human1.14911636
67CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14608978
68GATA1_22025678_ChIP-Seq_K562_Human1.14263591
69NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11961294
70SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.10009158
71PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09499493
72GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08549220
73STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08430236
74VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07744731
75SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06422853
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.04741624
77PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02949166
78GATA1_19941826_ChIP-Seq_K562_Human1.02230063
79ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00516731
80GATA1_19941827_ChIP-Seq_MEL_Mouse1.00054158
81CIITA_25753668_ChIP-Seq_RAJI_Human0.99647630
82KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98192183
83HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97819350
84GATA2_21666600_ChIP-Seq_HMVEC_Human0.96647926
85GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96448945
86KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95389564
87KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95040392
88BCOR_27268052_Chip-Seq_Bcells_Human0.94786224
89TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93595551
90PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93062914
91* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85308619
92ELK3_25401928_ChIP-Seq_HUVEC_Human0.83325751
93RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.83229568
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.82628127
95KDM2B_26808549_Chip-Seq_DND41_Human0.82569762
96ELF1_20517297_ChIP-Seq_JURKAT_Human0.81614981
97KDM2B_26808549_Chip-Seq_JURKAT_Human0.78480649
98RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.78326385
99P300_27268052_Chip-Seq_Bcells_Human0.75808577
100TFEB_21752829_ChIP-Seq_HELA_Human0.73324378
101TP63_19390658_ChIP-ChIP_HaCaT_Human0.66029854
102GATA2_19941826_ChIP-Seq_K562_Human0.65761102
103SPI1_20517297_ChIP-Seq_HL60_Human0.65084510
104IKZF1_21737484_ChIP-ChIP_HCT116_Human0.63939426
105FOXM1_23109430_ChIP-Seq_U2OS_Human0.62989381
106E2F4_17652178_ChIP-ChIP_JURKAT_Human0.60919217
107ETS1_22383799_ChIP-Seq_G1ME_Mouse0.59766524
108NCOR1_26117541_ChIP-Seq_K562_Human0.58988344
109BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.58459965
110EGR1_19032775_ChIP-ChIP_M12_Human0.58023980
111* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.57559418
112GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.57443091
113SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.57428972

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.69424378
2MP0003436_decreased_susceptibility_to3.48166339
3MP0003303_peritoneal_inflammation3.45781961
4MP0009785_altered_susceptibility_to3.40630172
5MP0001790_abnormal_immune_system3.39785052
6MP0005387_immune_system_phenotype3.39785052
7MP0001800_abnormal_humoral_immune3.25090775
8MP0000685_abnormal_immune_system3.23812154
9MP0005671_abnormal_response_to3.20580972
10MP0005000_abnormal_immune_tolerance3.19848043
11MP0002452_abnormal_antigen_presenting3.04649338
12MP0002148_abnormal_hypersensitivity_rea3.01736589
13MP0002419_abnormal_innate_immunity2.99161118
14MP0005025_abnormal_response_to2.94675235
15MP0002723_abnormal_immune_serum2.83056690
16MP0004510_myositis2.69922732
17MP0002420_abnormal_adaptive_immunity2.69542144
18MP0001819_abnormal_immune_cell2.68949368
19MP0006082_CNS_inflammation2.29838629
20MP0003724_increased_susceptibility_to2.21628677
21MP0002405_respiratory_system_inflammati2.19587445
22MP0002398_abnormal_bone_marrow2.17088567
23MP0005464_abnormal_platelet_physiology2.12046100
24MP0000716_abnormal_immune_system2.11816667
25MP0003763_abnormal_thymus_physiology2.05230896
26MP0010155_abnormal_intestine_physiology2.01303845
27MP0002166_altered_tumor_susceptibility1.99498149
28MP0001853_heart_inflammation1.98367327
29MP0005174_abnormal_tail_pigmentation1.97684498
30MP0009333_abnormal_splenocyte_physiolog1.94334822
31MP0004947_skin_inflammation1.94250184
32MP0001845_abnormal_inflammatory_respons1.87475003
33MP0000689_abnormal_spleen_morphology1.84744639
34MP0002006_tumorigenesis1.84620874
35MP0002396_abnormal_hematopoietic_system1.82393168
36MP0001873_stomach_inflammation1.81917916
37MP0009278_abnormal_bone_marrow1.78724437
38MP0002429_abnormal_blood_cell1.72634830
39MP0002722_abnormal_immune_system1.71455643
40MP0001533_abnormal_skeleton_physiology1.68957864
41MP0005058_abnormal_lysosome_morphology1.67163672
42MP0003172_abnormal_lysosome_physiology1.61828516
43MP0003183_abnormal_peptide_metabolism1.61497559
44MP0003300_gastrointestinal_ulcer1.58763812
45MP0005310_abnormal_salivary_gland1.58742426
46MP0000569_abnormal_digit_pigmentation1.56980261
47MP0001545_abnormal_hematopoietic_system1.56237923
48MP0005397_hematopoietic_system_phenotyp1.56237923
49MP0000015_abnormal_ear_pigmentation1.48288870
50MP0003448_altered_tumor_morphology1.46591212
51MP0008469_abnormal_protein_level1.44668581
52MP0009764_decreased_sensitivity_to1.37024577
53MP0002933_joint_inflammation1.31276121
54MP0000490_abnormal_crypts_of1.29361373
55MP0003866_abnormal_defecation1.28069967
56MP0000703_abnormal_thymus_morphology1.26546787
57MP0004808_abnormal_hematopoietic_stem1.25007689
58MP0002277_abnormal_respiratory_mucosa1.22104329
59MP0002138_abnormal_hepatobiliary_system1.20890304
60MP0000858_altered_metastatic_potential1.19908900
61MP0002998_abnormal_bone_remodeling1.15350776
62MP0000465_gastrointestinal_hemorrhage1.15279606
63MP0000343_altered_response_to1.12579991
64MP0005451_abnormal_body_composition1.11911582
65MP0003191_abnormal_cellular_cholesterol0.99197879
66MP0005075_abnormal_melanosome_morpholog0.92620945
67MP0004883_abnormal_blood_vessel0.92020879
68MP0003828_pulmonary_edema0.91605007
69MP0001851_eye_inflammation0.91310552
70MP0005076_abnormal_cell_differentiation0.91271376
71MP0009840_abnormal_foam_cell0.86715414
72MP0003806_abnormal_nucleotide_metabolis0.83611942
73MP0001663_abnormal_digestive_system0.83236985
74MP0000371_diluted_coat_color0.82482850
75MP0003690_abnormal_glial_cell0.82109102
76MP0003075_altered_response_to0.81932185
77MP0010307_abnormal_tumor_latency0.80299887
78MP0005166_decreased_susceptibility_to0.79355638
79MP0005390_skeleton_phenotype0.78873564
80MP0002095_abnormal_skin_pigmentation0.78427672
81MP0008260_abnormal_autophagy0.74838191
82MP0002019_abnormal_tumor_incidence0.74470752
83MP0009763_increased_sensitivity_to0.74231501
84MP0003656_abnormal_erythrocyte_physiolo0.72036357
85MP0008004_abnormal_stomach_pH0.70880376
86MP0008057_abnormal_DNA_replication0.70437923
87MP0010352_gastrointestinal_tract_polyps0.69935952
88MP0003453_abnormal_keratinocyte_physiol0.66711311
89MP0002132_abnormal_respiratory_system0.65353394
90MP0002254_reproductive_system_inflammat0.65056855
91MP0002136_abnormal_kidney_physiology0.60411258
92MP0000249_abnormal_blood_vessel0.59435419
93MP0001986_abnormal_taste_sensitivity0.59390244
94MP0004782_abnormal_surfactant_physiolog0.58380521
95MP0004381_abnormal_hair_follicle0.57260675
96MP0003646_muscle_fatigue0.56076956
97MP0003795_abnormal_bone_structure0.55674417
98MP0008874_decreased_physiological_sensi0.54515360
99MP0008873_increased_physiological_sensi0.52503025
100MP0008058_abnormal_DNA_repair0.51904968
101MP0000313_abnormal_cell_death0.48417166
102MP0009765_abnormal_xenobiotic_induced0.47327714
103MP0002009_preneoplasia0.46699923
104MP0005319_abnormal_enzyme/_coenzyme0.46655052
105MP0000604_amyloidosis0.45538047
106MP0005164_abnormal_response_to0.45324197
107MP0001191_abnormal_skin_condition0.45034666
108MP0003091_abnormal_cell_migration0.44720771
109MP0000920_abnormal_myelination0.43754606
110MP0002693_abnormal_pancreas_physiology0.43679492
111MP0005167_abnormal_blood-brain_barrier0.43020151
112MP0005381_digestive/alimentary_phenotyp0.42941275
113MP0003045_fibrosis0.42313172
114MP0000609_abnormal_liver_physiology0.41923336
115MP0004130_abnormal_muscle_cell0.41589843
116MP0005535_abnormal_body_temperature0.40388472

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.63409398
2Eczematoid dermatitis (HP:0000976)6.04442606
3Recurrent bacterial skin infections (HP:0005406)5.97516526
4Elevated erythrocyte sedimentation rate (HP:0003565)4.90058196
5Recurrent fungal infections (HP:0002841)4.67471045
6Myositis (HP:0100614)4.67132218
7Mediastinal lymphadenopathy (HP:0100721)4.53946288
8Recurrent gram-negative bacterial infections (HP:0005420)4.51877106
9Abnormality of macrophages (HP:0004311)4.36030434
10Recurrent viral infections (HP:0004429)4.29262552
11Chronic otitis media (HP:0000389)4.24453248
12Stomatitis (HP:0010280)4.20615866
13Recurrent skin infections (HP:0001581)4.18716067
14Retrobulbar optic neuritis (HP:0100654)4.13405997
15Optic neuritis (HP:0100653)4.13405997
16Orchitis (HP:0100796)4.03469775
17Chronic mucocutaneous candidiasis (HP:0002728)3.94944571
18Recurrent cutaneous fungal infections (HP:0011370)3.94944571
19Chronic obstructive pulmonary disease (HP:0006510)3.94245557
20Obstructive lung disease (HP:0006536)3.94245557
21Vasculitis (HP:0002633)3.80372847
22Meningitis (HP:0001287)3.78363476
23Cellulitis (HP:0100658)3.64864399
24Autoimmune thrombocytopenia (HP:0001973)3.63363344
25Agammaglobulinemia (HP:0004432)3.52751946
26Gingivitis (HP:0000230)3.52611040
27Recurrent bronchitis (HP:0002837)3.46313166
28IgM deficiency (HP:0002850)3.43105225
29Abnormal delayed hypersensitivity skin test (HP:0002963)3.30548410
30Inflammation of the large intestine (HP:0002037)3.26396899
31Colitis (HP:0002583)3.17501993
32Vacuolated lymphocytes (HP:0001922)3.09970236
33Pustule (HP:0200039)3.07738844
34Gastrointestinal inflammation (HP:0004386)3.03422972
35Panhypogammaglobulinemia (HP:0003139)3.00692336
36Pulmonary infiltrates (HP:0002113)2.96957392
37Recurrent pneumonia (HP:0006532)2.96777940
38Osteomyelitis (HP:0002754)2.89259917
39Pulmonary embolism (HP:0002204)2.85284571
40Gastrointestinal stroma tumor (HP:0100723)2.81835027
41Leukocytosis (HP:0001974)2.80598080
42Lymphopenia (HP:0001888)2.79159391
43Hypochromic anemia (HP:0001931)2.78688222
44Nasal polyposis (HP:0100582)2.78567694
45Increased IgM level (HP:0003496)2.75538563
46Recurrent sinusitis (HP:0011108)2.74545036
47Abnormality of cells of the lymphoid lineage (HP:0012140)2.73922335
48Hemoptysis (HP:0002105)2.70528607
49Periodontitis (HP:0000704)2.69901438
50Abnormality of T cell number (HP:0011839)2.69788126
51Thyroiditis (HP:0100646)2.68935343
52Urticaria (HP:0001025)2.67712523
53Gangrene (HP:0100758)2.66564594
54Abnormality of T cells (HP:0002843)2.65709941
55Recurrent lower respiratory tract infections (HP:0002783)2.65209250
56Chronic sinusitis (HP:0011109)2.63690723
57Chronic diarrhea (HP:0002028)2.63456778
58Anorexia (HP:0002039)2.62899631
59Eosinophilia (HP:0001880)2.62153416
60T lymphocytopenia (HP:0005403)2.60678428
61Cheilitis (HP:0100825)2.58799478
62Arterial thrombosis (HP:0004420)2.57353896
63Abnormality of T cell physiology (HP:0011840)2.55817235
64Prostate neoplasm (HP:0100787)2.55671607
65Hypochromic microcytic anemia (HP:0004840)2.55439028
66Keratoconjunctivitis sicca (HP:0001097)2.53979950
67Interstitial pulmonary disease (HP:0006530)2.52604144
68Encephalitis (HP:0002383)2.52307045
69Spontaneous hematomas (HP:0007420)2.50909199
70Thrombocytosis (HP:0001894)2.49360351
71Abnormality of the pleura (HP:0002103)2.48127055
72Abnormality of B cell number (HP:0010975)2.47074044
73B lymphocytopenia (HP:0010976)2.47074044
74Basal ganglia calcification (HP:0002135)2.44003627
75Increased IgE level (HP:0003212)2.43317478
76Petechiae (HP:0000967)2.41590037
77Abnormality of the nasal mucosa (HP:0000433)2.40903179
78Episodic fever (HP:0001954)2.40613891
79Hypergammaglobulinemia (HP:0010702)2.38043581
80Granulocytopenia (HP:0001913)2.36413256
81Abnormality of eosinophils (HP:0001879)2.34476183
82Keratoconjunctivitis (HP:0001096)2.31847355
83Abnormality of the prostate (HP:0008775)2.30360201
84IgG deficiency (HP:0004315)2.30036286
85Sepsis (HP:0100806)2.28044617
86Increased cerebral lipofuscin (HP:0011813)2.27878182
87Gingival bleeding (HP:0000225)2.26774751
88Emphysema (HP:0002097)2.25040556
89Microcytic anemia (HP:0001935)2.22136876
90Skin ulcer (HP:0200042)2.19589032
91Systemic lupus erythematosus (HP:0002725)2.19344059
92Abnormality of glycolipid metabolism (HP:0010969)2.16926031
93Abnormality of liposaccharide metabolism (HP:0010968)2.16926031
94Abnormality of glycosphingolipid metabolism (HP:0004343)2.16926031
95Severe combined immunodeficiency (HP:0004430)2.16422448
96IgA deficiency (HP:0002720)2.15918033
97Glomerulopathy (HP:0100820)2.15384597
98Prolonged bleeding time (HP:0003010)2.15331175
99Abnormality of the fingertips (HP:0001211)2.14591707
100Increased neuronal autofluorescent lipopigment (HP:0002074)2.13603250
101Polyneuropathy (HP:0001271)2.11749387
102Joint swelling (HP:0001386)2.11736818
103Keratitis (HP:0000491)2.10813929
104Combined immunodeficiency (HP:0005387)2.09108276
105Hematochezia (HP:0002573)2.08856635
106Purpura (HP:0000979)2.08199846
107Epistaxis (HP:0000421)2.07410005
108Gastrointestinal infarctions (HP:0005244)2.06444168
109Albinism (HP:0001022)2.06238967
110Lymphoma (HP:0002665)2.05989633
111Chest pain (HP:0100749)2.05376617
112Skin rash (HP:0000988)2.04066897
113Leukopenia (HP:0001882)2.02855497
114Restrictive lung disease (HP:0002091)2.01530256
115Vertigo (HP:0002321)2.00551595
116Premature loss of primary teeth (HP:0006323)1.96548126
117Increased serum ferritin (HP:0003281)1.95634287
118Amyloidosis (HP:0011034)1.94772566
119Dysostosis multiplex (HP:0000943)1.94503890
120Arthralgia (HP:0002829)1.93366223
121Papilloma (HP:0012740)1.93153563
122Verrucae (HP:0200043)1.93153563
123Autoimmune hemolytic anemia (HP:0001890)1.90131215

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.43185530
2MAP3K143.93411665
3TBK13.55698288
4IRAK43.34244300
5BLK3.11049161
6IKBKE3.05936554
7IRAK33.04565542
8RIPK42.87566911
9TYK22.77709408
10TXK2.75765283
11KIT2.59350141
12IKBKB2.57153943
13JAK32.34185331
14CSF1R1.89395534
15MAP3K131.83896125
16BTK1.79082803
17ZAP701.78143529
18SYK1.77123940
19TEC1.75850319
20PRPF4B1.75703486
21JAK11.71474749
22CLK11.58471440
23CSK1.58279507
24ERN11.58238267
25GRK61.53197207
26CHUK1.51677066
27FES1.50583962
28STK101.44811234
29PIM21.43162887
30HCK1.42658933
31TESK21.38120329
32LCK1.36500065
33PIM11.32313311
34TAOK31.30139773
35LYN1.29281580
36MAP3K101.28487051
37TGFBR21.20603664
38ITK1.17043358
39TAOK11.15861864
40NME21.14093868
41MAP3K11.12623144
42RPS6KA41.10926310
43SIK21.06478141
44SIK31.03407237
45MARK31.00899887
46PRKCH1.00098412
47MAP2K30.98945848
48MST40.98829498
49FGR0.87480853
50MATK0.87018775
51EPHB10.83741857
52STK40.83260723
53PIK3CG0.81660548
54NLK0.81090510
55EIF2AK20.79714333
56YES10.78326096
57RPS6KA60.75764041
58FGFR30.74911819
59CAMKK20.74100682
60FGFR40.73558428
61CDK120.72756680
62JAK20.70416035
63PBK0.69079449
64RPS6KL10.64834327
65RPS6KC10.64834327
66MAPK70.63322337
67TAOK20.60889122
68MAPK120.60300482
69LRRK20.58586405
70KSR20.56807878
71CDK190.56337766
72PRKCQ0.55621081
73ABL10.54940576
74TLK10.53362307
75MAP2K60.49542924
76MAP3K110.48714123
77MARK20.47369312
78BMPR20.46717153
79NEK90.46595871
80PRKCD0.46038031
81PDPK10.45893067
82FLT30.45008972
83EPHA30.44949138
84NUAK10.43968644
85IRAK10.43304960
86CDC42BPA0.42708189
87RPS6KA50.41680133
88CAMKK10.39149039
89IRAK20.38998849
90MAPK40.38977526
91ADRBK20.38751110
92EGFR0.36998122
93MAPKAPK20.36975475
94PRKD20.36956863
95MAPK110.36849609
96EIF2AK30.36021767
97TRPM70.34024518
98MAP2K20.33515675
99GRK70.32899901
100MAP3K50.32846280
101MAP3K60.32259329
102PTK2B0.31861172
103CDK40.31729456
104STK110.31710951
105BRD40.31513342
106RAF10.31481813
107MAP3K70.31078589
108TNK20.30994971
109PKN10.30922390
110HIPK20.30268506
111RET0.30261719
112KDR0.27650000
113PDK10.25675178
114MAP3K20.24706207
115DYRK1B0.23949401
116PRKG20.23668394
117DAPK10.23668095
118SMG10.23471213
119CDK60.23218931
120STK240.23154367
121MAPK30.22415428
122BMX0.22239204
123PTK60.22028946
124MAP3K30.21977650
125FYN0.21632943
126GRK10.18976018
127CAMK1D0.18119065
128EEF2K0.17606480
129CDK90.17553186

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.18334523
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.98084260
3Primary immunodeficiency_Homo sapiens_hsa053402.80097051
4Osteoclast differentiation_Homo sapiens_hsa043802.48915182
5B cell receptor signaling pathway_Homo sapiens_hsa046622.47287602
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.46125490
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.45174769
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.33369215
9Measles_Homo sapiens_hsa051622.32721681
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.32347406
11Allograft rejection_Homo sapiens_hsa053302.29361919
12NOD-like receptor signaling pathway_Homo sapiens_hsa046212.20769293
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.20329090
14Graft-versus-host disease_Homo sapiens_hsa053322.17793921
15Hematopoietic cell lineage_Homo sapiens_hsa046401.96995008
16Legionellosis_Homo sapiens_hsa051341.89610070
17Pertussis_Homo sapiens_hsa051331.88351667
18Malaria_Homo sapiens_hsa051441.85590064
19Tuberculosis_Homo sapiens_hsa051521.85066256
20Antigen processing and presentation_Homo sapiens_hsa046121.82497173
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.79568897
22Staphylococcus aureus infection_Homo sapiens_hsa051501.79099428
23Herpes simplex infection_Homo sapiens_hsa051681.75702680
24TNF signaling pathway_Homo sapiens_hsa046681.75450733
25Influenza A_Homo sapiens_hsa051641.74459913
26Asthma_Homo sapiens_hsa053101.72107972
27Toxoplasmosis_Homo sapiens_hsa051451.56863729
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.54420246
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.50649507
30T cell receptor signaling pathway_Homo sapiens_hsa046601.50580672
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.45545843
32Other glycan degradation_Homo sapiens_hsa005111.44550356
33Apoptosis_Homo sapiens_hsa042101.43072781
34Chemokine signaling pathway_Homo sapiens_hsa040621.41532182
35Shigellosis_Homo sapiens_hsa051311.39935604
36Rheumatoid arthritis_Homo sapiens_hsa053231.36574713
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.35590527
38Hepatitis B_Homo sapiens_hsa051611.34129819
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.27635300
40African trypanosomiasis_Homo sapiens_hsa051431.24575410
41Salmonella infection_Homo sapiens_hsa051321.22779080
42Acute myeloid leukemia_Homo sapiens_hsa052211.14381424
43Autoimmune thyroid disease_Homo sapiens_hsa053201.13593271
44Hepatitis C_Homo sapiens_hsa051601.06428490
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.06071543
46Lysosome_Homo sapiens_hsa041421.05151447
47Type I diabetes mellitus_Homo sapiens_hsa049401.05016271
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03776892
49Leukocyte transendothelial migration_Homo sapiens_hsa046701.02059118
50Epstein-Barr virus infection_Homo sapiens_hsa051690.96719187
51Phagosome_Homo sapiens_hsa041450.94341746
52Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91886978
53Viral myocarditis_Homo sapiens_hsa054160.90555510
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84594829
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82984887
56Chronic myeloid leukemia_Homo sapiens_hsa052200.81860656
57Pancreatic cancer_Homo sapiens_hsa052120.80731486
58Non-homologous end-joining_Homo sapiens_hsa034500.80179437
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77315042
60Platelet activation_Homo sapiens_hsa046110.72170945
61Viral carcinogenesis_Homo sapiens_hsa052030.70204383
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66708603
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.66635712
64HTLV-I infection_Homo sapiens_hsa051660.64334939
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63842475
66Base excision repair_Homo sapiens_hsa034100.63827448
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63465523
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60944447
69Prolactin signaling pathway_Homo sapiens_hsa049170.58614600
70p53 signaling pathway_Homo sapiens_hsa041150.54206812
71Homologous recombination_Homo sapiens_hsa034400.53978759
72Small cell lung cancer_Homo sapiens_hsa052220.52667058
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51961703
74DNA replication_Homo sapiens_hsa030300.44320535
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43557623
76Ribosome_Homo sapiens_hsa030100.42920088
77Endocytosis_Homo sapiens_hsa041440.41533141
78VEGF signaling pathway_Homo sapiens_hsa043700.40000059
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39958865
80Caffeine metabolism_Homo sapiens_hsa002320.38267457
81Amoebiasis_Homo sapiens_hsa051460.37926128
82Systemic lupus erythematosus_Homo sapiens_hsa053220.37530404
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.36852117
84Fanconi anemia pathway_Homo sapiens_hsa034600.36688806
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.34985959
86HIF-1 signaling pathway_Homo sapiens_hsa040660.34414394
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.34162542
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33735704
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33181076
90FoxO signaling pathway_Homo sapiens_hsa040680.33000272
91Dorso-ventral axis formation_Homo sapiens_hsa043200.32904388
92Non-small cell lung cancer_Homo sapiens_hsa052230.32264610
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.32039492
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30626222
95Inositol phosphate metabolism_Homo sapiens_hsa005620.29310230
96Colorectal cancer_Homo sapiens_hsa052100.29126360
97Renal cell carcinoma_Homo sapiens_hsa052110.29114755
98MAPK signaling pathway_Homo sapiens_hsa040100.29017087
99Choline metabolism in cancer_Homo sapiens_hsa052310.28977060
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28635488
101Insulin resistance_Homo sapiens_hsa049310.28276676
102Notch signaling pathway_Homo sapiens_hsa043300.28133449
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27783432
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26951215
105Regulation of autophagy_Homo sapiens_hsa041400.25490956
106Sphingolipid metabolism_Homo sapiens_hsa006000.24328901
107Type II diabetes mellitus_Homo sapiens_hsa049300.24278449
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.23623098
109MicroRNAs in cancer_Homo sapiens_hsa052060.22352321
110Arachidonic acid metabolism_Homo sapiens_hsa005900.22265385
111Mismatch repair_Homo sapiens_hsa034300.22227543
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.17447989
113mTOR signaling pathway_Homo sapiens_hsa041500.16831488
114Endometrial cancer_Homo sapiens_hsa052130.16130684
115Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.16088981
116Collecting duct acid secretion_Homo sapiens_hsa049660.13282944
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.13114695

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