SNX21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. The specific function of this protein has not been determined. Multiple transcript variants encoding distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1barbed-end actin filament capping (GO:0051016)4.49307007
2protein heterotrimerization (GO:0070208)4.35512494
3cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.32176699
4positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.20688955
5regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.03578164
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.01257380
7regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.98490948
8cell communication by electrical coupling (GO:0010644)3.94458132
9extracellular fibril organization (GO:0043206)3.90003821
10synaptic vesicle exocytosis (GO:0016079)3.81277152
11regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.73969317
12regulation of short-term neuronal synaptic plasticity (GO:0048172)3.73492806
13positive regulation of potassium ion transmembrane transport (GO:1901381)3.65756371
14sodium ion export (GO:0071436)3.60027242
15actin-myosin filament sliding (GO:0033275)3.59964657
16muscle filament sliding (GO:0030049)3.59964657
17regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.57785429
18regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.53188738
19negative regulation of cytosolic calcium ion concentration (GO:0051481)3.51760947
20membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.50813458
21cellular potassium ion homeostasis (GO:0030007)3.48994706
22cell communication involved in cardiac conduction (GO:0086065)3.47732504
23synaptic vesicle maturation (GO:0016188)3.44159674
24regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.43910122
25extracellular matrix assembly (GO:0085029)3.41679531
26regulation of skeletal muscle contraction (GO:0014819)3.37844283
27regulation of synapse structural plasticity (GO:0051823)3.37654273
28cell migration involved in heart development (GO:0060973)3.33572495
29fibril organization (GO:0097435)3.22090670
30regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.21291319
31negative regulation of synaptic transmission, GABAergic (GO:0032229)3.18789947
32type B pancreatic cell proliferation (GO:0044342)3.16669365
33low-density lipoprotein particle clearance (GO:0034383)3.16623139
34actin-mediated cell contraction (GO:0070252)3.15770522
35neuronal action potential propagation (GO:0019227)3.13493940
36protein localization to synapse (GO:0035418)3.13284739
37kidney mesenchyme development (GO:0072074)3.10861144
38membrane depolarization during action potential (GO:0086010)3.07036253
39metanephric mesenchyme development (GO:0072075)3.05309557
40endothelial cell chemotaxis (GO:0035767)3.04464626
41peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.04244288
42regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.02153796
43regulation of membrane repolarization (GO:0060306)3.00728953
44vocalization behavior (GO:0071625)2.97087621
45positive regulation of potassium ion transport (GO:0043268)2.97043262
46cGMP-mediated signaling (GO:0019934)2.95123334
47glutamate secretion (GO:0014047)2.94907819
48neurotransmitter secretion (GO:0007269)2.92833156
49cellular sodium ion homeostasis (GO:0006883)2.92297894
50vascular endothelial growth factor signaling pathway (GO:0038084)2.91027664
51negative regulation of protein localization to cell surface (GO:2000009)2.88954032
52regulation of synaptic vesicle exocytosis (GO:2000300)2.86783812
53potassium ion homeostasis (GO:0055075)2.84994701
54regulation of cell communication by electrical coupling (GO:0010649)2.84160331
55urinary tract smooth muscle contraction (GO:0014848)2.83573845
56plasma membrane repair (GO:0001778)2.83028530
57cardiac myofibril assembly (GO:0055003)2.82708871
58positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.82359718
59cellular response to epinephrine stimulus (GO:0071872)2.82297694
60collagen fibril organization (GO:0030199)2.81131727
61positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.80041603
62planar cell polarity pathway involved in neural tube closure (GO:0090179)2.78854885
63skin morphogenesis (GO:0043589)2.78531496
64regulation of vesicle fusion (GO:0031338)2.78459498
65activation of protein kinase A activity (GO:0034199)2.77282964
66response to pheromone (GO:0019236)2.75610764
67proline transport (GO:0015824)2.75566293
68potassium ion export (GO:0071435)2.74504978
69regulation of sequestering of triglyceride (GO:0010889)2.74435907
70regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.74316788
71cell migration in hindbrain (GO:0021535)2.73460505
72detection of calcium ion (GO:0005513)2.73409849
73myofibril assembly (GO:0030239)2.72426628
74neuromuscular process controlling posture (GO:0050884)2.70776220
75locomotory exploration behavior (GO:0035641)2.70678838
76positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.70322729
77regulation of synaptic vesicle transport (GO:1902803)2.69446677
78detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.68051193
79detection of temperature stimulus involved in sensory perception (GO:0050961)2.68051193
80cerebellar Purkinje cell differentiation (GO:0021702)2.67390199
81sequestering of extracellular ligand from receptor (GO:0035581)2.65963926
82calcium-mediated signaling using intracellular calcium source (GO:0035584)2.64490187
83membrane repolarization (GO:0086009)2.64442842
84response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.62356956
85neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.61024924
86positive regulation of synaptic transmission, GABAergic (GO:0032230)2.58613809
87cardiac muscle contraction (GO:0060048)2.58432956
88basement membrane organization (GO:0071711)2.57261872
89regulation of calcium ion transmembrane transport (GO:1903169)2.56899880
90regulation of calcium ion transmembrane transporter activity (GO:1901019)2.56899880
91regulation of potassium ion transmembrane transport (GO:1901379)2.55824085
92drinking behavior (GO:0042756)2.55032547
93endothelial cell morphogenesis (GO:0001886)2.53823476
94regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.53676578
95negative regulation of potassium ion transmembrane transport (GO:1901380)2.52630435
96neurotransmitter transport (GO:0006836)2.51855859
97stress fiber assembly (GO:0043149)2.51396334
98gamma-aminobutyric acid transport (GO:0015812)2.51102803
99regulation of integrin-mediated signaling pathway (GO:2001044)2.50432528
100adhesion of symbiont to host cell (GO:0044650)2.50161262
101virion attachment to host cell (GO:0019062)2.50161262
102regulation of neuronal synaptic plasticity (GO:0048168)2.49936343
103sarcoplasmic reticulum calcium ion transport (GO:0070296)2.48930397
104cell-substrate junction assembly (GO:0007044)2.48489037
105neuromuscular synaptic transmission (GO:0007274)2.48047565
106endodermal cell differentiation (GO:0035987)2.47877282
107desmosome organization (GO:0002934)2.47823072
108neuronal action potential (GO:0019228)2.47229922
109regulation of actin filament-based movement (GO:1903115)2.47206581
110regulation of voltage-gated calcium channel activity (GO:1901385)2.47045937
111G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.46672596
112regulation of glutamate receptor signaling pathway (GO:1900449)2.46082813
113regulation of long-term neuronal synaptic plasticity (GO:0048169)2.45665871
114potassium ion import (GO:0010107)2.44963993
115protein localization to cell surface (GO:0034394)2.44080796
116cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.42008839
117ventricular cardiac muscle cell action potential (GO:0086005)2.41859922
118regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.41735382
119regulation of heart rate by cardiac conduction (GO:0086091)2.41577542
120mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.41500237
121regulation of extracellular matrix disassembly (GO:0010715)2.40483171
122negative regulation of fatty acid transport (GO:2000192)2.40087201
123adhesion of symbiont to host (GO:0044406)2.39931908
124metanephric tubule development (GO:0072170)2.39679400
125metanephric nephron tubule development (GO:0072234)2.39679400
126metanephric nephron epithelium development (GO:0072243)2.39076110
127response to epinephrine (GO:0071871)2.38951382
128layer formation in cerebral cortex (GO:0021819)2.38852538
129mating behavior (GO:0007617)2.38539814
130regulation of cardiac muscle contraction (GO:0055117)2.38350102
131regulation of potassium ion transmembrane transporter activity (GO:1901016)2.37079143
132regulation of the force of heart contraction (GO:0002026)2.36969670
133membrane depolarization (GO:0051899)2.34831741
134negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.34662535
135skeletal muscle fiber development (GO:0048741)2.34613530
136detection of temperature stimulus (GO:0016048)2.34338752
137regulation of excitatory postsynaptic membrane potential (GO:0060079)2.34163870
138sarcomere organization (GO:0045214)2.34108177
139semaphorin-plexin signaling pathway (GO:0071526)2.33907079
140actin filament-based movement (GO:0030048)2.33708290
141negative regulation of smooth muscle cell migration (GO:0014912)2.33692064
142positive regulation of protein targeting to membrane (GO:0090314)2.33373107
143positive regulation of fatty acid beta-oxidation (GO:0032000)2.33173885
144neuron cell-cell adhesion (GO:0007158)2.33118822
145skeletal muscle contraction (GO:0003009)2.32929645
146retina vasculature morphogenesis in camera-type eye (GO:0061299)2.32558830
147regulation of relaxation of muscle (GO:1901077)2.32122819
148peptidyl-proline hydroxylation (GO:0019511)2.32094857
149glycogen catabolic process (GO:0005980)2.31756726
150regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.31273490
151action potential (GO:0001508)2.30832824
152regulation of cation channel activity (GO:2001257)2.30653940
153regulation of striated muscle contraction (GO:0006942)2.30280526
154muscle contraction (GO:0006936)2.30266410
155regulation of cardiac muscle cell contraction (GO:0086004)2.30160628
156glutamate receptor signaling pathway (GO:0007215)2.29565865
157hemidesmosome assembly (GO:0031581)2.29391577
158synaptic vesicle docking involved in exocytosis (GO:0016081)2.29039057
159negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.28878425
160cardiac conduction (GO:0061337)2.28496455
161adherens junction assembly (GO:0034333)2.28357042
162keratan sulfate catabolic process (GO:0042340)2.28090171
163positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.27979521
164cardiac muscle cell action potential involved in contraction (GO:0086002)2.27715828
165muscle cell migration (GO:0014812)2.27660128
166blood vessel maturation (GO:0001955)2.27511346
167regulation of postsynaptic membrane potential (GO:0060078)2.27356594
168regulation of neurotransmitter levels (GO:0001505)2.27310728
169cytoskeletal anchoring at plasma membrane (GO:0007016)2.26827664
170dermatan sulfate metabolic process (GO:0030205)2.25060501
171dermatan sulfate biosynthetic process (GO:0030208)2.23537850
172protein targeting to plasma membrane (GO:0072661)2.23368310
173epithelial cell-cell adhesion (GO:0090136)2.23144504
174cochlea morphogenesis (GO:0090103)2.22568436
175cell-substrate adherens junction assembly (GO:0007045)2.22073441
176focal adhesion assembly (GO:0048041)2.22073441
177response to dietary excess (GO:0002021)2.21991375
178regulation of early endosome to late endosome transport (GO:2000641)2.21626846
179NADH metabolic process (GO:0006734)2.21064290
180protein hydroxylation (GO:0018126)2.18484521
181apoptotic cell clearance (GO:0043277)2.18046264
182regulation of tight junction assembly (GO:2000810)2.17765545
183positive regulation of fatty acid oxidation (GO:0046321)2.16856458
184response to muscle activity (GO:0014850)2.16554617
185negative regulation of protein autophosphorylation (GO:0031953)2.16154175
186positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.16142570
187myotube cell development (GO:0014904)2.15002118
188striated muscle contraction (GO:0006941)2.14942508
189axon extension involved in axon guidance (GO:0048846)2.13169600
190neuron projection extension involved in neuron projection guidance (GO:1902284)2.13169600
191positive regulation of receptor recycling (GO:0001921)2.12896725
192skeletal muscle tissue development (GO:0007519)2.12835563
193middle ear morphogenesis (GO:0042474)2.12712056

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.13505529
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.45839584
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.07030131
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.95987844
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.73125097
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.72505303
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.72505303
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.71082518
9SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.57821851
10MTF2_20144788_ChIP-Seq_MESCs_Mouse2.56050921
11GBX2_23144817_ChIP-Seq_PC3_Human2.56027740
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50644996
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49095431
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.48414637
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.46038536
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.45932427
17EZH2_27294783_Chip-Seq_ESCs_Mouse2.38047276
18TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.33359440
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24593565
20TP63_17297297_ChIP-ChIP_HaCaT_Human2.11505320
21RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.09638066
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.03600808
23ZNF274_21170338_ChIP-Seq_K562_Hela2.03284964
24AR_21572438_ChIP-Seq_LNCaP_Human2.01733610
25ESR1_21235772_ChIP-Seq_MCF-7_Human1.98427838
26ELK3_25401928_ChIP-Seq_HUVEC_Human1.95678358
27RACK7_27058665_Chip-Seq_MCF-7_Human1.93024038
28TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92888834
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92765836
30CLOCK_20551151_ChIP-Seq_293T_Human1.90869892
31DROSHA_22980978_ChIP-Seq_HELA_Human1.86945938
32REST_21632747_ChIP-Seq_MESCs_Mouse1.84559842
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.77942227
34* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71974431
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64826531
36RARB_27405468_Chip-Seq_BRAIN_Mouse1.62239950
37REST_18959480_ChIP-ChIP_MESCs_Mouse1.61442417
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.60204340
39* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.60094795
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.59556880
41UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.57755780
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53742380
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.52792205
44TBX20_22328084_ChIP-Seq_HEART_Mouse1.50444958
45TBX20_22080862_ChIP-Seq_HEART_Mouse1.50444958
46ZNF263_19887448_ChIP-Seq_K562_Human1.47579953
47SMC3_22415368_ChIP-Seq_MEFs_Mouse1.47200595
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45562665
49ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.45005027
50HIF1A_21447827_ChIP-Seq_MCF-7_Human1.42000495
51TP53_23651856_ChIP-Seq_MEFs_Mouse1.41458498
52SMC1_22415368_ChIP-Seq_MEFs_Mouse1.39787416
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39134959
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.35873496
55EP300_21415370_ChIP-Seq_HL-1_Mouse1.35640308
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34780328
57TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.33354914
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32597106
59SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.31406716
60EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30656706
61SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30379121
62DNAJC2_21179169_ChIP-ChIP_NT2_Human1.29820545
63* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.29817958
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29261017
65RING1B_27294783_Chip-Seq_ESCs_Mouse1.28704139
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28304891
67RARG_19884340_ChIP-ChIP_MEFs_Mouse1.28241627
68TET1_21451524_ChIP-Seq_MESCs_Mouse1.27961225
69TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27774283
70KDM2B_26808549_Chip-Seq_K562_Human1.27041899
71CTCF_27219007_Chip-Seq_Bcells_Human1.26292385
72TP53_22127205_ChIP-Seq_IMR90_Human1.26285926
73PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.25897194
74NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.24023701
75P68_20966046_ChIP-Seq_HELA_Human1.23475012
76P63_26484246_Chip-Seq_KERATINOCYTES_Human1.23241976
77NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23137294
78TP53_20018659_ChIP-ChIP_R1E_Mouse1.21707199
79P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21266757
80MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17502017
81* RXR_22158963_ChIP-Seq_LIVER_Mouse1.16685203
82CJUN_26792858_Chip-Seq_BT549_Human1.15943117
83SMC4_20622854_ChIP-Seq_HELA_Human1.15823081
84SOX9_24532713_ChIP-Seq_HFSC_Mouse1.15624147
85CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15517728
86FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.15187470
87THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14661579
88RAD21_21589869_ChIP-Seq_MESCs_Mouse1.14313798
89CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14041724
90ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13514391
91PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13327875
92* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13308687
93CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10435953
94CBX2_27304074_Chip-Seq_ESCs_Mouse1.09863657
95SA1_27219007_Chip-Seq_ERYTHROID_Human1.09104025
96ATF3_27146783_Chip-Seq_COLON_Human1.08938332
97ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08751390
98* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.08170005
99TP63_22573176_ChIP-Seq_HFKS_Human1.07788796
100KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07685794
101SMAD4_21799915_ChIP-Seq_A2780_Human1.07639709
102MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.06614538
103SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06483263
104ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06171728
105WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03926038
106SOX2_21211035_ChIP-Seq_LN229_Gbm1.03317124
107RING1B_27294783_Chip-Seq_NPCs_Mouse1.02905489
108PIAS1_25552417_ChIP-Seq_VCAP_Human1.02723454
109KDM2B_26808549_Chip-Seq_DND41_Human1.01731685
110UBF1/2_26484160_Chip-Seq_HMECs_Human1.01693119
111CREB1_26743006_Chip-Seq_LNCaP_Human1.00580875
112SA1_22415368_ChIP-Seq_MEFs_Mouse1.00297068
113CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99849536
114NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99841132
115SMAD4_21741376_ChIP-Seq_HESCs_Human0.99209430
116STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.98715706
117ESR1_20079471_ChIP-ChIP_T-47D_Human0.98183084
118OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98167125
119AR_25329375_ChIP-Seq_VCAP_Human0.98004454
120SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97718093
121ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97640265
122* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97421037
123* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.96151167
124ESR2_21235772_ChIP-Seq_MCF-7_Human0.95587286
125ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95162679
126TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94502462
127AR_19668381_ChIP-Seq_PC3_Human0.94478913
128TAF15_26573619_Chip-Seq_HEK293_Human0.93694057
129SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.91296955
130VDR_22108803_ChIP-Seq_LS180_Human0.90085588
131TET1_21490601_ChIP-Seq_MESCs_Mouse0.90061394
132ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89718913
133RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.89676210
134CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.88799578
135P53_22127205_ChIP-Seq_FIBROBLAST_Human0.87680912
136SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85962419
137EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.85214952
138TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.84361058
139SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81578124
140LXR_22292898_ChIP-Seq_THP-1_Human0.80236744
141MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.80208461
142PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.79377941
143AHR_22903824_ChIP-Seq_MCF-7_Human0.79231379
144MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.79193941
145P300_19829295_ChIP-Seq_ESCs_Human0.79181282
146BCAT_22108803_ChIP-Seq_LS180_Human0.78535229
147CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.73589617
148UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.73575485
149SMAD3_21741376_ChIP-Seq_HESCs_Human0.73380813
150* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.73355001
151KLF4_19829295_ChIP-Seq_ESCs_Human0.72483894
152RNF2_27304074_Chip-Seq_NSC_Mouse0.72356125
153TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.72251412
154SMAD3_21741376_ChIP-Seq_EPCs_Human0.71922496

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.63606011
2MP0003705_abnormal_hypodermis_morpholog3.51887165
3MP0004270_analgesia3.29427776
4MP0002735_abnormal_chemical_nociception3.06779974
5MP0001968_abnormal_touch/_nociception3.04550444
6MP0000751_myopathy2.98932839
7MP0002837_dystrophic_cardiac_calcinosis2.90079865
8MP0001958_emphysema2.86788141
9MP0004272_abnormal_basement_membrane2.78937187
10MP0003635_abnormal_synaptic_transmissio2.63039898
11MP0002736_abnormal_nociception_after2.56084888
12MP0004858_abnormal_nervous_system2.46293273
13MP0003279_aneurysm2.44842521
14MP0002734_abnormal_mechanical_nocicepti2.27211091
15MP0005257_abnormal_intraocular_pressure2.25697438
16MP0004215_abnormal_myocardial_fiber2.18842390
17MP0009745_abnormal_behavioral_response2.16647445
18MP0006276_abnormal_autonomic_nervous2.13627250
19MP0010030_abnormal_orbit_morphology2.10714161
20MP0004145_abnormal_muscle_electrophysio2.08052838
21MP0003950_abnormal_plasma_membrane2.07978012
22MP0002272_abnormal_nervous_system2.05446236
23MP0000749_muscle_degeneration2.03551923
24MP0002108_abnormal_muscle_morphology2.00932979
25MP0002064_seizures1.98948568
26MP0003880_abnormal_central_pattern1.98296174
27MP0004036_abnormal_muscle_relaxation1.94369993
28MP0009046_muscle_twitch1.90787946
29MP0002733_abnormal_thermal_nociception1.89400716
30MP0002822_catalepsy1.88588208
31MP0004084_abnormal_cardiac_muscle1.87144984
32MP0010386_abnormal_urinary_bladder1.84522122
33MP0002909_abnormal_adrenal_gland1.77848169
34MP0002063_abnormal_learning/memory/cond1.76041072
35MP0001970_abnormal_pain_threshold1.75879117
36MP0009384_cardiac_valve_regurgitation1.75814533
37MP0001986_abnormal_taste_sensitivity1.74377974
38MP0004510_myositis1.72300269
39MP0001542_abnormal_bone_strength1.65597869
40MP0003329_amyloid_beta_deposits1.63523549
41MP0000013_abnormal_adipose_tissue1.61156552
42MP0002572_abnormal_emotion/affect_behav1.60219646
43MP0002067_abnormal_sensory_capabilities1.60036784
44MP0008569_lethality_at_weaning1.57409690
45MP0002060_abnormal_skin_morphology1.57357258
46MP0002184_abnormal_innervation1.54671983
47MP0001486_abnormal_startle_reflex1.54538709
48MP0001440_abnormal_grooming_behavior1.52120090
49MP0004085_abnormal_heartbeat1.51426716
50MP0001188_hyperpigmentation1.50189754
51MP0002295_abnormal_pulmonary_circulatio1.46041359
52MP0003195_calcinosis1.45636335
53MP0005508_abnormal_skeleton_morphology1.44692310
54MP0001299_abnormal_eye_distance/1.42748364
55MP0003137_abnormal_impulse_conducting1.41111236
56MP0002638_abnormal_pupillary_reflex1.40849895
57MP0003566_abnormal_cell_adhesion1.40007484
58MP0005375_adipose_tissue_phenotype1.39317617
59MP0002971_abnormal_brown_adipose1.36815432
60MP0005620_abnormal_muscle_contractility1.36142671
61MP0003646_muscle_fatigue1.35542415
62MP0005595_abnormal_vascular_smooth1.35462144
63MP0000767_abnormal_smooth_muscle1.34077819
64MP0010368_abnormal_lymphatic_system1.33798912
65MP0002972_abnormal_cardiac_muscle1.33708670
66MP0005330_cardiomyopathy1.32658698
67MP0005423_abnormal_somatic_nervous1.31377114
68MP0000733_abnormal_muscle_development1.30897206
69MP0002796_impaired_skin_barrier1.27648215
70MP0000747_muscle_weakness1.26619100
71MP0008872_abnormal_physiological_respon1.25779174
72MP0005551_abnormal_eye_electrophysiolog1.25223257
73MP0009840_abnormal_foam_cell1.24870470
74MP0008438_abnormal_cutaneous_collagen1.24421223
75MP0008775_abnormal_heart_ventricle1.23985683
76MP0001501_abnormal_sleep_pattern1.21523931
77MP0002254_reproductive_system_inflammat1.20664671
78MP0005666_abnormal_adipose_tissue1.20515429
79MP0002557_abnormal_social/conspecific_i1.20304382
80MP0005023_abnormal_wound_healing1.18391902
81MP0005171_absent_coat_pigmentation1.17783597
82MP0005058_abnormal_lysosome_morphology1.16711958
83MP0002896_abnormal_bone_mineralization1.16305956
84MP0005646_abnormal_pituitary_gland1.13959167
85MP0005275_abnormal_skin_tensile1.13179701
86MP0002234_abnormal_pharynx_morphology1.12791255
87MP0004130_abnormal_muscle_cell1.09167338
88MP0005503_abnormal_tendon_morphology1.08719277
89MP0001661_extended_life_span1.08506744
90MP0001984_abnormal_olfaction1.07917981
91MP0006072_abnormal_retinal_apoptosis1.07679762
92MP0000003_abnormal_adipose_tissue1.07386942
93MP0004087_abnormal_muscle_fiber1.06909404
94MP0004924_abnormal_behavior1.05731840
95MP0005386_behavior/neurological_phenoty1.05731840
96MP0002882_abnormal_neuron_morphology1.04428120
97MP0004484_altered_response_of1.04363506
98MP0000955_abnormal_spinal_cord1.02705529
99MP0009780_abnormal_chondrocyte_physiolo1.01963883
100MP0000759_abnormal_skeletal_muscle1.01792662
101MP0005409_darkened_coat_color1.01145516
102MP0001502_abnormal_circadian_rhythm0.99063953
103MP0006138_congestive_heart_failure0.95601999
104MP0002106_abnormal_muscle_physiology0.95043798
105MP0000230_abnormal_systemic_arterial0.94641793
106MP0001270_distended_abdomen0.94232779
107MP0004185_abnormal_adipocyte_glucose0.93168704
108MP0004233_abnormal_muscle_weight0.92922465
109MP0002066_abnormal_motor_capabilities/c0.92753203
110MP0004811_abnormal_neuron_physiology0.92671275
111MP0009379_abnormal_foot_pigmentation0.92578269
112MP0001905_abnormal_dopamine_level0.92423252
113MP0000534_abnormal_ureter_morphology0.91641948
114MP0004142_abnormal_muscle_tone0.91444771
115MP0001243_abnormal_dermal_layer0.91067686
116MP0005369_muscle_phenotype0.90194718
117MP0005623_abnormal_meninges_morphology0.88478509
118MP0005501_abnormal_skin_physiology0.87989045
119MP0004043_abnormal_pH_regulation0.87779952
120MP0009250_abnormal_appendicular_skeleto0.87189133
121MP0002229_neurodegeneration0.86535594
122MP0000750_abnormal_muscle_regeneration0.86337639
123MP0003122_maternal_imprinting0.86024375
124MP0003091_abnormal_cell_migration0.85583029
125MP0002090_abnormal_vision0.85425979
126MP0004742_abnormal_vestibular_system0.84987880
127MP0002269_muscular_atrophy0.84712813
128MP0002249_abnormal_larynx_morphology0.84269548
129MP0005645_abnormal_hypothalamus_physiol0.82734205
130MP0003879_abnormal_hair_cell0.82252208
131MP0000778_abnormal_nervous_system0.81386586
132MP0005535_abnormal_body_temperature0.81322097
133MP0004885_abnormal_endolymph0.80402793
134MP0000762_abnormal_tongue_morphology0.79983188
135MP0003191_abnormal_cellular_cholesterol0.78678688
136MP0005165_increased_susceptibility_to0.78588473
137MP0005385_cardiovascular_system_phenoty0.78480181
138MP0001544_abnormal_cardiovascular_syste0.78480181
139MP0002332_abnormal_exercise_endurance0.77955607
140MP0005670_abnormal_white_adipose0.77279350
141MP0000163_abnormal_cartilage_morphology0.76321905
142MP0005253_abnormal_eye_physiology0.76086561
143MP0001849_ear_inflammation0.75334911
144MP0000462_abnormal_digestive_system0.75254901
145MP0003453_abnormal_keratinocyte_physiol0.71676852
146MP0010771_integument_phenotype0.71302397
147MP0003959_abnormal_lean_body0.66175013
148MP0003942_abnormal_urinary_system0.65175546
149MP0010630_abnormal_cardiac_muscle0.63889949
150MP0002128_abnormal_blood_circulation0.62325958
151MP0002970_abnormal_white_adipose0.61841166
152MP0001756_abnormal_urination0.61765120
153MP0002933_joint_inflammation0.59415485
154MP0000049_abnormal_middle_ear0.59057049
155MP0001879_abnormal_lymphatic_vessel0.59041460
156MP0003011_delayed_dark_adaptation0.58905316
157MP0002877_abnormal_melanocyte_morpholog0.58850321
158MP0005390_skeleton_phenotype0.58480615

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.93172485
2Premature rupture of membranes (HP:0001788)4.91643473
3Myokymia (HP:0002411)4.44509478
4Nemaline bodies (HP:0003798)4.36515937
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.21283265
6Muscle fiber inclusion bodies (HP:0100299)4.20706850
7Sudden death (HP:0001699)4.14141334
8Focal motor seizures (HP:0011153)3.58955745
9Aortic aneurysm (HP:0004942)3.55527463
10Exercise-induced myalgia (HP:0003738)3.55101296
11Vertebral compression fractures (HP:0002953)3.50195675
12Round ear (HP:0100830)3.44214632
13Ankle contracture (HP:0006466)3.40396360
14Visual hallucinations (HP:0002367)3.34575157
15Prolonged QT interval (HP:0001657)3.33155983
16Mildly elevated creatine phosphokinase (HP:0008180)3.32009158
17Action tremor (HP:0002345)3.27750446
18Atrial fibrillation (HP:0005110)3.23739691
19Slender build (HP:0001533)3.23633285
20Calf muscle hypertrophy (HP:0008981)3.21043021
21Vascular tortuosity (HP:0004948)3.19178461
22Muscle hypertrophy of the lower extremities (HP:0008968)3.17554485
23Primary atrial arrhythmia (HP:0001692)3.13337574
24Shallow orbits (HP:0000586)3.11019811
25Progressive cerebellar ataxia (HP:0002073)3.08848616
26Ventricular fibrillation (HP:0001663)3.01964538
27Supraventricular tachycardia (HP:0004755)3.00338103
28Hyporeflexia of lower limbs (HP:0002600)2.96989325
29Supraventricular arrhythmia (HP:0005115)2.95139994
30Aortic dissection (HP:0002647)2.94995228
31Bladder diverticulum (HP:0000015)2.93989207
32Soft skin (HP:0000977)2.92495335
33Wormian bones (HP:0002645)2.88656928
34Increased variability in muscle fiber diameter (HP:0003557)2.87781093
35Cervical subluxation (HP:0003308)2.86976836
36Abnormality of the calf musculature (HP:0001430)2.86031668
37Abnormal EKG (HP:0003115)2.83831060
38Syncope (HP:0001279)2.79323720
39Myotonia (HP:0002486)2.77541973
40Pheochromocytoma (HP:0002666)2.74024435
41Focal seizures (HP:0007359)2.71370844
42Hypoventilation (HP:0002791)2.70067422
43Arterial tortuosity (HP:0005116)2.69697895
44Neck muscle weakness (HP:0000467)2.66830019
45Ulnar deviation of the wrist (HP:0003049)2.62775096
46Myopathic facies (HP:0002058)2.58137477
47Distal lower limb amyotrophy (HP:0008944)2.54093848
48Anxiety (HP:0000739)2.53296847
49Wrist flexion contracture (HP:0001239)2.52561824
50Fragile skin (HP:0001030)2.50841630
51Depression (HP:0000716)2.50474862
52Follicular hyperkeratosis (HP:0007502)2.49713976
53Muscle fiber splitting (HP:0003555)2.47653623
54Bundle branch block (HP:0011710)2.45843800
55Cerebral aneurysm (HP:0004944)2.45479908
56Coronal craniosynostosis (HP:0004440)2.44216537
57Neuroendocrine neoplasm (HP:0100634)2.43839736
58Atrophic scars (HP:0001075)2.43826079
59Hypothermia (HP:0002045)2.43624215
60Ulnar bowing (HP:0003031)2.39829854
61Exercise-induced muscle cramps (HP:0003710)2.39675428
62Ventricular arrhythmia (HP:0004308)2.38049205
63Ventricular tachycardia (HP:0004756)2.36207085
64Myoglobinuria (HP:0002913)2.36014804
65Palpitations (HP:0001962)2.34772277
66Distal arthrogryposis (HP:0005684)2.32934210
67Epileptic encephalopathy (HP:0200134)2.32663834
68Ankle clonus (HP:0011448)2.31947583
69Abnormality of skeletal muscle fiber size (HP:0012084)2.31235614
70Cardiovascular calcification (HP:0011915)2.30947689
71Blue sclerae (HP:0000592)2.30496943
72Centrally nucleated skeletal muscle fibers (HP:0003687)2.29966321
73Hyperacusis (HP:0010780)2.29141101
74Neonatal hypoglycemia (HP:0001998)2.28909110
75Dysdiadochokinesis (HP:0002075)2.28064388
76Atonic seizures (HP:0010819)2.24927652
77Febrile seizures (HP:0002373)2.24066196
78Difficulty climbing stairs (HP:0003551)2.23827975
79Generalized amyotrophy (HP:0003700)2.22754821
80Hip contracture (HP:0003273)2.22132153
81Overgrowth (HP:0001548)2.21962600
82Ulnar claw (HP:0001178)2.21718312
83Infantile muscular hypotonia (HP:0008947)2.19642921
84Acanthosis nigricans (HP:0000956)2.17998346
85Joint stiffness (HP:0001387)2.16956611
86Bradycardia (HP:0001662)2.15143434
87Hyperextensible skin (HP:0000974)2.13637374
88Distal lower limb muscle weakness (HP:0009053)2.12561666
89Scapular winging (HP:0003691)2.11870754
90Osteolytic defects of the hand bones (HP:0009699)2.11245492
91Osteolytic defects of the phalanges of the hand (HP:0009771)2.11245492
92Bell-shaped thorax (HP:0001591)2.11205020
93Generalized tonic-clonic seizures (HP:0002069)2.10675688
94Aplasia involving bones of the upper limbs (HP:0009823)2.10342563
95Aplasia of the phalanges of the hand (HP:0009802)2.10342563
96Aplasia involving bones of the extremities (HP:0009825)2.10342563
97Nonprogressive disorder (HP:0003680)2.08720312
98Oligomenorrhea (HP:0000876)2.07870905
99Type 1 muscle fiber predominance (HP:0003803)2.07690902
100Mitral regurgitation (HP:0001653)2.07418518
101EMG: myopathic abnormalities (HP:0003458)2.05785556
102Upper limb amyotrophy (HP:0009129)2.05527669
103Distal upper limb amyotrophy (HP:0007149)2.05527669
104Mitral stenosis (HP:0001718)2.04055036
105Lower limb amyotrophy (HP:0007210)2.03868146
106Hypoplastic left heart (HP:0004383)2.03684882
107Genu recurvatum (HP:0002816)2.02629949
108Hepatoblastoma (HP:0002884)2.01093987
109Limb dystonia (HP:0002451)2.01081272
110Absence seizures (HP:0002121)2.00789688
111Hemiparesis (HP:0001269)2.00042104
112Torticollis (HP:0000473)1.99790674
113Agitation (HP:0000713)1.99335866
114Muscle stiffness (HP:0003552)1.98485430
115Obstructive sleep apnea (HP:0002870)1.97690700
116Limited hip movement (HP:0008800)1.96559304
117Supranuclear gaze palsy (HP:0000605)1.96096709
118Dilatation of the ascending aorta (HP:0005111)1.95999955
119Asymmetric septal hypertrophy (HP:0001670)1.95835180
120Aneurysm (HP:0002617)1.95632772
121Elbow flexion contracture (HP:0002987)1.95263513
122Biconcave vertebral bodies (HP:0004586)1.94266460
123Hypercortisolism (HP:0001578)1.93990842
124Rhabdomyolysis (HP:0003201)1.92587926
125Acute necrotizing encephalopathy (HP:0006965)1.92348969
126Foot dorsiflexor weakness (HP:0009027)1.91626065
127Mask-like facies (HP:0000298)1.91607387
128Difficulty running (HP:0009046)1.91493542
129Truncal ataxia (HP:0002078)1.90554006
130Heart block (HP:0012722)1.89947624
131Aplasia of the musculature (HP:0100854)1.89817270
132Broad face (HP:0000283)1.89752525
133Aortic regurgitation (HP:0001659)1.89453235
134Abnormal atrioventricular conduction (HP:0005150)1.88557794
135Dilated cardiomyopathy (HP:0001644)1.88082898
136Broad metatarsal (HP:0001783)1.87922276
137Left ventricular hypertrophy (HP:0001712)1.87809230
138Limb-girdle muscle weakness (HP:0003325)1.87593085
139Neoplasm of the adrenal gland (HP:0100631)1.87533120
140Genetic anticipation (HP:0003743)1.87077638
141Turricephaly (HP:0000262)1.87035285
142Hemiplegia (HP:0002301)1.86784984
143Bowel diverticulosis (HP:0005222)1.86608571
144Popliteal pterygium (HP:0009756)1.86223424
145Gowers sign (HP:0003391)1.85823482
146Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.84901073
147Vascular calcification (HP:0004934)1.84713529
148Abnormal mitochondria in muscle tissue (HP:0008316)1.84128817
149Megalencephaly (HP:0001355)1.80435347
150Retinal dysplasia (HP:0007973)1.80319638
151Ketoacidosis (HP:0001993)1.79981241
152Lipoatrophy (HP:0100578)1.79420306
153Abnormality of the foot musculature (HP:0001436)1.78506631
154Reduced subcutaneous adipose tissue (HP:0003758)1.78333637
155Focal dystonia (HP:0004373)1.78084918
156Joint laxity (HP:0001388)1.77693953
157Neonatal short-limb short stature (HP:0008921)1.77600799
158Bulbar palsy (HP:0001283)1.76675328
159Hypophosphatemic rickets (HP:0004912)1.76577276
160Dialeptic seizures (HP:0011146)1.75217723
161Steppage gait (HP:0003376)1.75134341
162Abnormality of the Achilles tendon (HP:0005109)1.74675171
163Spinal rigidity (HP:0003306)1.74571531
164Abnormal gallbladder physiology (HP:0012438)1.74064156
165Cholecystitis (HP:0001082)1.74064156
166Abnormality of dentin (HP:0010299)1.73794444
167Craniofacial dystonia (HP:0012179)1.73182935
168Increased connective tissue (HP:0009025)1.72560778
169Mitochondrial inheritance (HP:0001427)1.71968130
170Right ventricular cardiomyopathy (HP:0011663)1.71441829
171Facial shape deformation (HP:0011334)1.68934527
172Potter facies (HP:0002009)1.68934527
173EEG with generalized epileptiform discharges (HP:0011198)1.68705672
174Broad-based gait (HP:0002136)1.67572793
175Achilles tendon contracture (HP:0001771)1.67341976

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K43.90217114
2LMTK23.74800234
3MAP2K73.40187931
4TRIB32.94051524
5NTRK32.80233640
6PHKG22.68544392
7PHKG12.68544392
8DDR22.55376408
9CAMKK22.40653830
10MAP2K42.26183570
11ABL22.16097154
12MYLK2.16081961
13EPHB21.99991962
14NTRK11.91137618
15RIPK11.89356083
16LATS21.87102599
17MAP3K61.86859485
18SIK11.79482892
19MINK11.79205449
20MARK11.71432719
21PRKG21.62148794
22MAP3K91.61990412
23MUSK1.61598126
24EPHA21.58855301
25MOS1.58737310
26PINK11.57113027
27EPHB11.51081554
28DAPK21.49721621
29PRPF4B1.48171963
30EPHA41.47001926
31EPHA31.45382134
32TGFBR21.40409315
33ICK1.36533275
34CAMKK11.35424094
35OBSCN1.35346573
36MAP3K21.35159723
37MAP2K31.33798718
38KSR21.31900096
39LIMK11.29465859
40GRK51.29095830
41PAK21.28857700
42PAK61.27858108
43ERN11.26537766
44INSRR1.24799169
45STK381.22641458
46TNIK1.21466698
47NEK91.20416325
48CAMK2D1.17930052
49MAP3K121.14785691
50FER1.14362326
51MAP3K71.13009921
52CASK1.11826506
53RET1.11022192
54MAP3K31.10847327
55PRKD31.10564315
56PRKD21.03914972
57TTN1.02262272
58MAPK151.01819247
59CDC42BPA1.00799391
60SGK2231.00635142
61SGK4941.00635142
62PAK30.99029836
63CAMK2G0.98337252
64EEF2K0.96917909
65CDK30.95024229
66NTRK20.94525751
67CAMK2A0.94477487
68PAK40.93918242
69MAPK130.91491258
70PIK3CG0.89568746
71MAP2K10.89339269
72CDK50.88460544
73CAMK1G0.87091861
74MAPK70.85362354
75PDGFRA0.84645262
76MET0.84251214
77SGK20.84069801
78CAMK2B0.83961045
79CAMK10.83315766
80PRKCG0.83121657
81WNK40.82579297
82MTOR0.81922912
83PKN20.81509231
84STK38L0.80260756
85PDGFRB0.78406841
86DAPK30.76051345
87WNK10.74890675
88PTK2B0.72667119
89LATS10.72307108
90PRKCE0.71901108
91UHMK10.71505585
92PRKD10.71298355
93TAOK20.70765233
94IRAK30.68925142
95ROCK10.67410209
96PIM20.66816564
97TNK20.65948316
98MARK20.65891479
99GSK3A0.65245267
100MAPKAPK30.65148138
101ARAF0.65126418
102NME10.63338817
103TIE10.63128374
104MAP3K10.61871018
105ERBB40.61185238
106SMG10.61122634
107GRK70.60903505
108PKN10.57825741
109AKT20.57628917
110PRKAA20.55967518
111TRPM70.55914244
112BCKDK0.54047628
113MAPKAPK50.53135956
114MAPK120.53059405
115PDK40.52891621
116PDK30.52891621
117PRKAA10.52081184
118ROCK20.51016923
119CAMK1D0.50804874
120RPS6KC10.50680057
121RPS6KL10.50680057
122DMPK0.49847639
123PAK10.49139966
124PRKCH0.48638826
125SGK30.48344170
126TLK10.47675706
127PRKACA0.47611293
128PTK20.47346993
129RPS6KA20.46970722
130TESK10.46562721
131CDK140.46159140
132MAP2K60.45957456
133MAPK40.45822167
134DYRK1A0.45192879
135ILK0.44019953
136AKT30.44000994
137RPS6KA60.43081988
138TYRO30.42520137
139STK390.40062692
140ADRBK10.40034598
141DAPK10.39380368
142PDPK10.39051287
143CDK80.38479358
144NEK20.38386579
145CAMK40.37080511
146MAPK110.36891473

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.63950575
2Synaptic vesicle cycle_Homo sapiens_hsa047212.51387389
3Cardiac muscle contraction_Homo sapiens_hsa042602.47810474
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.26497279
5Olfactory transduction_Homo sapiens_hsa047402.17464667
6Nicotine addiction_Homo sapiens_hsa050332.16583196
7Insulin secretion_Homo sapiens_hsa049112.09055723
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.03101947
9Focal adhesion_Homo sapiens_hsa045102.02602028
10Sulfur relay system_Homo sapiens_hsa041221.98319408
11Circadian entrainment_Homo sapiens_hsa047131.97163661
12Oxidative phosphorylation_Homo sapiens_hsa001901.96517358
13GABAergic synapse_Homo sapiens_hsa047271.92049764
14Glutamatergic synapse_Homo sapiens_hsa047241.89731546
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.83498726
16Parkinsons disease_Homo sapiens_hsa050121.80080033
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.75684487
18Dopaminergic synapse_Homo sapiens_hsa047281.72517425
19Morphine addiction_Homo sapiens_hsa050321.72343300
20Taste transduction_Homo sapiens_hsa047421.71735781
21Salivary secretion_Homo sapiens_hsa049701.69527280
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.66516154
23Long-term potentiation_Homo sapiens_hsa047201.66055211
24Renin secretion_Homo sapiens_hsa049241.64944454
25Alzheimers disease_Homo sapiens_hsa050101.63819660
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.62746198
27Gastric acid secretion_Homo sapiens_hsa049711.60696479
28Cholinergic synapse_Homo sapiens_hsa047251.59228924
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.58473914
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.56944214
31Amphetamine addiction_Homo sapiens_hsa050311.56345084
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.55605736
33Dilated cardiomyopathy_Homo sapiens_hsa054141.54211788
34Serotonergic synapse_Homo sapiens_hsa047261.51175088
35Oxytocin signaling pathway_Homo sapiens_hsa049211.35507161
36Calcium signaling pathway_Homo sapiens_hsa040201.34654690
37Collecting duct acid secretion_Homo sapiens_hsa049661.32251426
38Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.32189982
39Long-term depression_Homo sapiens_hsa047301.28875008
40Cocaine addiction_Homo sapiens_hsa050301.26253760
41Adipocytokine signaling pathway_Homo sapiens_hsa049201.23570958
42GnRH signaling pathway_Homo sapiens_hsa049121.22737221
43Tight junction_Homo sapiens_hsa045301.22403733
44Protein digestion and absorption_Homo sapiens_hsa049741.21223118
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19738032
46Gap junction_Homo sapiens_hsa045401.19241396
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16984695
48Ovarian steroidogenesis_Homo sapiens_hsa049131.15818099
49Proteoglycans in cancer_Homo sapiens_hsa052051.11646887
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09955120
51Huntingtons disease_Homo sapiens_hsa050161.09505596
52Vibrio cholerae infection_Homo sapiens_hsa051101.08974991
53Type II diabetes mellitus_Homo sapiens_hsa049301.07612247
54Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.06606899
55Vascular smooth muscle contraction_Homo sapiens_hsa042701.04309979
56Melanogenesis_Homo sapiens_hsa049161.02317202
57cAMP signaling pathway_Homo sapiens_hsa040241.01042008
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00112877
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.98623105
60Pancreatic secretion_Homo sapiens_hsa049720.97419406
61Regulation of actin cytoskeleton_Homo sapiens_hsa048100.96467313
62Histidine metabolism_Homo sapiens_hsa003400.96090172
63Amoebiasis_Homo sapiens_hsa051460.91497585
64Tyrosine metabolism_Homo sapiens_hsa003500.90162281
65Glucagon signaling pathway_Homo sapiens_hsa049220.88202477
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87008748
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86216579
68Other glycan degradation_Homo sapiens_hsa005110.84004078
69Arginine and proline metabolism_Homo sapiens_hsa003300.83721426
70Lysosome_Homo sapiens_hsa041420.83525465
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83183933
72Circadian rhythm_Homo sapiens_hsa047100.82096806
73Axon guidance_Homo sapiens_hsa043600.80690126
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80597599
75beta-Alanine metabolism_Homo sapiens_hsa004100.80278127
76Phototransduction_Homo sapiens_hsa047440.79098997
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78888416
78Bile secretion_Homo sapiens_hsa049760.77894311
79Vitamin B6 metabolism_Homo sapiens_hsa007500.76894933
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76557039
81Fatty acid degradation_Homo sapiens_hsa000710.75204874
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74999428
83Propanoate metabolism_Homo sapiens_hsa006400.73743710
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73694489
85Estrogen signaling pathway_Homo sapiens_hsa049150.73347374
86Thyroid hormone synthesis_Homo sapiens_hsa049180.72872454
87Insulin signaling pathway_Homo sapiens_hsa049100.72430775
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70946452
89Butanoate metabolism_Homo sapiens_hsa006500.70789664
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69903738
91PI3K-Akt signaling pathway_Homo sapiens_hsa041510.69143474
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.68988816
93ErbB signaling pathway_Homo sapiens_hsa040120.68709956
94Arginine biosynthesis_Homo sapiens_hsa002200.68674965
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68212305
96Endocytosis_Homo sapiens_hsa041440.67679374
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.67557057
98Adherens junction_Homo sapiens_hsa045200.67149234
99Pyruvate metabolism_Homo sapiens_hsa006200.67032682
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66833601
101Fatty acid metabolism_Homo sapiens_hsa012120.66446374
102Bladder cancer_Homo sapiens_hsa052190.66339323
103Hippo signaling pathway_Homo sapiens_hsa043900.66116915
104Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63579599
105Galactose metabolism_Homo sapiens_hsa000520.62115993
106Basal cell carcinoma_Homo sapiens_hsa052170.62066457
107Prion diseases_Homo sapiens_hsa050200.62021500
108Folate biosynthesis_Homo sapiens_hsa007900.58714181
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54311490
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.53924365
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.52812783
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.52275891
113Glioma_Homo sapiens_hsa052140.51883121
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51148346
115Mineral absorption_Homo sapiens_hsa049780.51003627
116Choline metabolism in cancer_Homo sapiens_hsa052310.50741874
117Phenylalanine metabolism_Homo sapiens_hsa003600.49370884
118Wnt signaling pathway_Homo sapiens_hsa043100.49094789
119Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48851644
120Sulfur metabolism_Homo sapiens_hsa009200.45620444
121Fatty acid elongation_Homo sapiens_hsa000620.45546110
122Glycerolipid metabolism_Homo sapiens_hsa005610.44811521
123Fructose and mannose metabolism_Homo sapiens_hsa000510.43123658
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.42835412
125AMPK signaling pathway_Homo sapiens_hsa041520.41327761
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41038053
127Insulin resistance_Homo sapiens_hsa049310.40985441
128Ras signaling pathway_Homo sapiens_hsa040140.40227344
129VEGF signaling pathway_Homo sapiens_hsa043700.39284318
130MAPK signaling pathway_Homo sapiens_hsa040100.37918115
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.37610877
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37563965
133Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37141917
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36478522
135PPAR signaling pathway_Homo sapiens_hsa033200.36327418
136Melanoma_Homo sapiens_hsa052180.36304413
137Carbon metabolism_Homo sapiens_hsa012000.35758907
138Rap1 signaling pathway_Homo sapiens_hsa040150.34402186
139Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34354760
140Hedgehog signaling pathway_Homo sapiens_hsa043400.33003194
141Starch and sucrose metabolism_Homo sapiens_hsa005000.31983825

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