SNX22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a sorting nexin that is found in the cytoplasm, where it interacts with membrane-bound phosphatidylinositol 3-phosphate. The encoded protein may play a role in intracellular trafficking. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)8.79101637
2translational termination (GO:0006415)8.55427606
3SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.61926571
4ribosomal large subunit biogenesis (GO:0042273)7.61189642
5cotranslational protein targeting to membrane (GO:0006613)7.54447168
6protein targeting to ER (GO:0045047)7.53460941
7establishment of protein localization to endoplasmic reticulum (GO:0072599)7.17082207
8protein localization to endoplasmic reticulum (GO:0070972)7.04824606
9ribosomal small subunit biogenesis (GO:0042274)7.01539002
10translational elongation (GO:0006414)6.95264930
11cellular protein complex disassembly (GO:0043624)6.69164797
12viral life cycle (GO:0019058)6.61179127
13nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.22261472
14ribosomal small subunit assembly (GO:0000028)6.05856374
15mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.04836089
16translational initiation (GO:0006413)5.97623459
17maturation of SSU-rRNA (GO:0030490)5.69778134
18protein complex disassembly (GO:0043241)5.66680568
19water-soluble vitamin biosynthetic process (GO:0042364)5.63142597
20energy coupled proton transport, down electrochemical gradient (GO:0015985)5.53231939
21ATP synthesis coupled proton transport (GO:0015986)5.53231939
22macromolecular complex disassembly (GO:0032984)5.39902496
23protein targeting to membrane (GO:0006612)5.05838641
24short-term memory (GO:0007614)4.93465081
25mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.85893369
26glucosamine-containing compound catabolic process (GO:1901072)4.70232636
27translation (GO:0006412)4.68705410
28ncRNA 3-end processing (GO:0043628)4.59297789
29mitotic nuclear envelope reassembly (GO:0007084)4.57770236
30nuclear envelope reassembly (GO:0031468)4.57770236
31mitochondrial respiratory chain complex I assembly (GO:0032981)4.54689392
32NADH dehydrogenase complex assembly (GO:0010257)4.54689392
33mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.54689392
34pattern specification involved in kidney development (GO:0061004)4.38572824
35transcription elongation from RNA polymerase III promoter (GO:0006385)4.37128323
36termination of RNA polymerase III transcription (GO:0006386)4.37128323
37electron transport chain (GO:0022900)4.33530551
38respiratory electron transport chain (GO:0022904)4.33163225
39chaperone-mediated protein transport (GO:0072321)4.28133611
40nuclear-transcribed mRNA catabolic process (GO:0000956)4.19043080
41DNA replication checkpoint (GO:0000076)4.16590220
42rRNA modification (GO:0000154)4.08509405
43DNA ligation (GO:0006266)4.08209153
44mRNA catabolic process (GO:0006402)3.97390682
45protoporphyrinogen IX metabolic process (GO:0046501)3.95706428
46ribonucleoprotein complex biogenesis (GO:0022613)3.94950834
47behavioral response to nicotine (GO:0035095)3.92314306
48establishment of protein localization to mitochondrial membrane (GO:0090151)3.91431576
49rRNA methylation (GO:0031167)3.83514918
50cullin deneddylation (GO:0010388)3.81826938
51DNA damage response, detection of DNA damage (GO:0042769)3.80246806
52proteasome assembly (GO:0043248)3.77529488
53signal peptide processing (GO:0006465)3.77260809
54skin morphogenesis (GO:0043589)3.69244585
55endothelium development (GO:0003158)3.68095620
56RNA catabolic process (GO:0006401)3.64909053
57spliceosomal complex assembly (GO:0000245)3.64162202
58protein-cofactor linkage (GO:0018065)3.63401632
59spliceosomal snRNP assembly (GO:0000387)3.58403022
60regulation of protein kinase C signaling (GO:0090036)3.56146028
61positive regulation of chemokine secretion (GO:0090197)3.48076727
62protein deneddylation (GO:0000338)3.46516620
63L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.43877884
64cellular component biogenesis (GO:0044085)3.36370688
65heme biosynthetic process (GO:0006783)3.35590076
66establishment of protein localization to membrane (GO:0090150)3.34186689
67hydrogen ion transmembrane transport (GO:1902600)3.32673967
68DNA deamination (GO:0045006)3.31843445
69intra-S DNA damage checkpoint (GO:0031573)3.30989693
70response to lead ion (GO:0010288)3.29457889
71protein targeting (GO:0006605)3.29415137
72rRNA processing (GO:0006364)3.28025619
73GTP biosynthetic process (GO:0006183)3.25749425
74exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.23730909
75ATP biosynthetic process (GO:0006754)3.21936930
76sulfation (GO:0051923)3.20068009
77nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.19836457
78RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.18864010
79tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.18864010
80cellular ketone body metabolic process (GO:0046950)3.15591208
81CENP-A containing nucleosome assembly (GO:0034080)3.13151156
82rRNA metabolic process (GO:0016072)3.12383399
83respiratory chain complex IV assembly (GO:0008535)3.09949709
84pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.09855613
85protein neddylation (GO:0045116)3.09155307
86proton transport (GO:0015992)3.08845317
87protein complex biogenesis (GO:0070271)3.08174811
88protein K11-linked ubiquitination (GO:0070979)3.05810644
89chromatin remodeling at centromere (GO:0031055)3.05420571
90pseudouridine synthesis (GO:0001522)3.04828304
91positive regulation of DNA repair (GO:0045739)3.04466481
92hydrogen transport (GO:0006818)3.02972903
93cytochrome complex assembly (GO:0017004)3.02677710
94establishment of protein localization to organelle (GO:0072594)3.02351114
95intracellular protein transmembrane import (GO:0044743)3.02281970
96telomere maintenance via semi-conservative replication (GO:0032201)3.01266239
97cellular response to ATP (GO:0071318)3.00444786
98histone deubiquitination (GO:0016578)2.99143194
99regulation of mitotic spindle organization (GO:0060236)2.98747182
100negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.97209509
101purine nucleoside triphosphate biosynthetic process (GO:0009145)2.97083887
102preassembly of GPI anchor in ER membrane (GO:0016254)2.96461352
103cellular response to zinc ion (GO:0071294)2.95593312
104tRNA processing (GO:0008033)2.95195879
105tryptophan catabolic process (GO:0006569)2.95185516
106indole-containing compound catabolic process (GO:0042436)2.95185516
107indolalkylamine catabolic process (GO:0046218)2.95185516
108sphingoid metabolic process (GO:0046519)2.92667904
109DNA catabolic process, exonucleolytic (GO:0000738)2.89842678
110purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.89634002
111pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.88515434
112regulation of metalloenzyme activity (GO:0048552)2.87157576
113tRNA modification (GO:0006400)2.84577511
114mannosylation (GO:0097502)2.81735583
115negative regulation of DNA-dependent DNA replication (GO:2000104)2.81205313
116response to folic acid (GO:0051593)2.81161186
117cellular response to exogenous dsRNA (GO:0071360)2.80978021
118regulation of cell aging (GO:0090342)2.80772209
119embryonic body morphogenesis (GO:0010172)2.80532050
120ketone body metabolic process (GO:1902224)2.79299735
121iron-sulfur cluster assembly (GO:0016226)2.78837508
122metallo-sulfur cluster assembly (GO:0031163)2.78837508
123vitamin biosynthetic process (GO:0009110)2.74506372
124kynurenine metabolic process (GO:0070189)2.74413230
125indolalkylamine metabolic process (GO:0006586)2.74384524
126positive regulation of defense response to virus by host (GO:0002230)2.74034143
127kinetochore assembly (GO:0051382)2.73897374
128mammary gland epithelial cell differentiation (GO:0060644)2.72418361
129transcription elongation from RNA polymerase I promoter (GO:0006362)2.72397912
130mitochondrial respiratory chain complex assembly (GO:0033108)2.72333170
131pteridine-containing compound biosynthetic process (GO:0042559)2.71812897
132kinetochore organization (GO:0051383)2.69828126
133regulation of DNA repair (GO:0006282)2.69200486
134DNA strand elongation involved in DNA replication (GO:0006271)2.67171397
135regulation of chemokine secretion (GO:0090196)2.66676757
136regulation of mitochondrial translation (GO:0070129)2.66374178
137mitochondrion morphogenesis (GO:0070584)2.64745835
138protein localization to membrane (GO:0072657)2.64447198
139maturation of 5.8S rRNA (GO:0000460)2.64273357
140Arp2/3 complex-mediated actin nucleation (GO:0034314)2.63998519
141UTP biosynthetic process (GO:0006228)2.61832516
142telomere maintenance via recombination (GO:0000722)2.61453139
143cellular protein complex localization (GO:0034629)2.60881082
144protein targeting to mitochondrion (GO:0006626)2.60501452
145diol metabolic process (GO:0034311)2.60155590
146cytidine deamination (GO:0009972)2.60015022
147cytidine metabolic process (GO:0046087)2.60015022
148cytidine catabolic process (GO:0006216)2.60015022
149recombinational repair (GO:0000725)2.59531088
150double-strand break repair via homologous recombination (GO:0000724)2.59420727
151peptidyl-arginine omega-N-methylation (GO:0035247)2.59413476
152positive regulation of protein autophosphorylation (GO:0031954)2.58426214
153deoxyribonucleotide catabolic process (GO:0009264)2.58396560
154negative regulation of telomere maintenance (GO:0032205)2.58245414
155L-methionine biosynthetic process (GO:0071265)2.57675828
156tryptophan metabolic process (GO:0006568)2.56527524
157protein K6-linked ubiquitination (GO:0085020)2.55531089
158positive regulation of protein homodimerization activity (GO:0090073)2.53129068
159parturition (GO:0007567)2.51106138
160establishment of protein localization to mitochondrion (GO:0072655)2.49436287
161L-fucose catabolic process (GO:0042355)2.45743694
162fucose catabolic process (GO:0019317)2.45743694
163L-fucose metabolic process (GO:0042354)2.45743694
164negative regulation of mast cell activation (GO:0033004)2.44827112
165regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.43916561
166ncRNA processing (GO:0034470)2.42873907
167platelet dense granule organization (GO:0060155)2.42862254
1683-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.42159270
169purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.42159270

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.76031871
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.65571643
3E2F7_22180533_ChIP-Seq_HELA_Human4.64650280
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.42294449
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.09778275
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.70972681
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.46477617
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.37621590
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.34640275
10GABP_17652178_ChIP-ChIP_JURKAT_Human3.29898998
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.21361554
12E2F4_17652178_ChIP-ChIP_JURKAT_Human3.19238003
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.13004578
14* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.10707507
15ETS1_20019798_ChIP-Seq_JURKAT_Human3.09852494
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.95419494
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.91946737
18XRN2_22483619_ChIP-Seq_HELA_Human2.90942329
19DCP1A_22483619_ChIP-Seq_HELA_Human2.82721438
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.80760014
21TTF2_22483619_ChIP-Seq_HELA_Human2.70873007
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.67424914
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.65970751
24TRIM28_21343339_ChIP-Seq_HEK293_Human2.55324623
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.43959989
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.38066637
27VDR_23849224_ChIP-Seq_CD4+_Human2.35315926
28FOXP3_21729870_ChIP-Seq_TREG_Human2.23479213
29CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.23106041
30VDR_22108803_ChIP-Seq_LS180_Human2.21450674
31ZNF274_21170338_ChIP-Seq_K562_Hela2.20278932
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.13132864
33E2F1_18555785_ChIP-Seq_MESCs_Mouse2.05002140
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.99963520
35IRF8_22096565_ChIP-ChIP_GC-B_Human1.96717107
36ELK1_22589737_ChIP-Seq_MCF10A_Human1.95802372
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94582592
38MYC_18940864_ChIP-ChIP_HL60_Human1.93720378
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.93562789
40EWS_26573619_Chip-Seq_HEK293_Human1.87701373
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.82886976
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.82095037
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.81270032
44KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.78619147
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.73817049
46RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69359125
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.68663097
48KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.65073391
49KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.65073391
50KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.65073391
51GABP_19822575_ChIP-Seq_HepG2_Human1.64055080
52ELK1_19687146_ChIP-ChIP_HELA_Human1.63025848
53IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.62437822
54TP53_22573176_ChIP-Seq_HFKS_Human1.61210588
55FUS_26573619_Chip-Seq_HEK293_Human1.60221837
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.59486930
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58971678
58IRF1_19129219_ChIP-ChIP_H3396_Human1.54111972
59TP63_17297297_ChIP-ChIP_HaCaT_Human1.53768906
60BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.51468868
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.50578724
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.48236307
63EZH2_22144423_ChIP-Seq_EOC_Human1.48166487
64TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.47719684
65NELFA_20434984_ChIP-Seq_ESCs_Mouse1.46225943
66TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.46218331
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42569094
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40105306
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.37564781
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37442222
71FOXA1_27270436_Chip-Seq_PROSTATE_Human1.35007720
72FOXA1_25329375_ChIP-Seq_VCAP_Human1.35007720
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33720056
74FLI1_27457419_Chip-Seq_LIVER_Mouse1.32852764
75ER_23166858_ChIP-Seq_MCF-7_Human1.32130333
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30962780
77ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30336797
78TAF15_26573619_Chip-Seq_HEK293_Human1.30069209
79MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26954692
80KDM5A_27292631_Chip-Seq_BREAST_Human1.23482457
81CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.23331523
82IRF8_21731497_ChIP-ChIP_J774_Mouse1.23214167
83POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22575190
84MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21697985
85GBX2_23144817_ChIP-Seq_PC3_Human1.20384939
86GATA3_21878914_ChIP-Seq_MCF-7_Human1.20356479
87PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18777091
88EGR1_23403033_ChIP-Seq_LIVER_Mouse1.18485309
89SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18056970
90NANOG_19829295_ChIP-Seq_ESCs_Human1.17672664
91SOX2_19829295_ChIP-Seq_ESCs_Human1.17672664
92AR_20517297_ChIP-Seq_VCAP_Human1.17249804
93NCOR_22424771_ChIP-Seq_293T_Human1.16339785
94CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.16183215
95SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15943603
96ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15628895
97* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15008151
98CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13269552
99SRF_21415370_ChIP-Seq_HL-1_Mouse1.12551085
100PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12383625
101CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12097101
102IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11960212
103DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09420782
104ERA_21632823_ChIP-Seq_H3396_Human1.09178468
105EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08251110
106SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06929261
107CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04536752
108P300_19829295_ChIP-Seq_ESCs_Human1.03892697
109MYC_19829295_ChIP-Seq_ESCs_Human1.03514465
110GATA3_26560356_Chip-Seq_TH2_Human1.03464385
111TAF2_19829295_ChIP-Seq_ESCs_Human1.03136428
112ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02294040
113BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01765144
114PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.00809356
115CTCF_18555785_ChIP-Seq_MESCs_Mouse1.00338522
116AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99829482
117CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99820862
118NANOG_20526341_ChIP-Seq_ESCs_Human0.99638486
119VDR_21846776_ChIP-Seq_THP-1_Human0.98747868
120* VDR_24763502_ChIP-Seq_THP-1_Human0.97614368
121AR_21909140_ChIP-Seq_LNCAP_Human0.95093320
122GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94444805
123FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93893789
124* ERG_20517297_ChIP-Seq_VCAP_Human0.93328755
125P53_21459846_ChIP-Seq_SAOS-2_Human0.92988465
126ETV2_25802403_ChIP-Seq_MESCs_Mouse0.92742178
127MAF_26560356_Chip-Seq_TH2_Human0.92237627
128PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91072701
129IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90916968
130CBP_20019798_ChIP-Seq_JUKART_Human0.90916968
131MYCN_18555785_ChIP-Seq_MESCs_Mouse0.90707488
132TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90565031
133* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90200411
134HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90104923
135BCAT_22108803_ChIP-Seq_LS180_Human0.90046941
136TDRD3_21172665_ChIP-Seq_MCF-7_Human0.89858896
137HOXB7_26014856_ChIP-Seq_BT474_Human0.89765397
138FOXH1_21741376_ChIP-Seq_EPCs_Human0.89244346
139RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.88523575
140PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88439653
141UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88064568
142PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86196987
143CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.85996220
144KLF4_18555785_ChIP-Seq_MESCs_Mouse0.84923225
145STAT1_20625510_ChIP-Seq_HELA_Human0.84905537
146TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84698580
147PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.83917094
148* SPI1_23547873_ChIP-Seq_NB4_Human0.82507348
149YY1_21170310_ChIP-Seq_MESCs_Mouse0.81558404
150SOX17_20123909_ChIP-Seq_XEN_Mouse0.81312072
151GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79078344
152POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.77573455
153RBPJ_22232070_ChIP-Seq_NCS_Mouse0.77096308
154STAT4_19710469_ChIP-ChIP_TH1__Mouse0.74222675
155FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73961936
156ESR1_15608294_ChIP-ChIP_MCF-7_Human0.73210105
157SMC3_22415368_ChIP-Seq_MEFs_Mouse0.72589700
158EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.72557850
159SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.71710530
160CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.71301844
161BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.71023327
162POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.70430870

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation9.28759587
2MP0003303_peritoneal_inflammation3.54095719
3MP0003724_increased_susceptibility_to3.48788894
4MP0003941_abnormal_skin_development3.16390633
5MP0003806_abnormal_nucleotide_metabolis2.91115290
6MP0008438_abnormal_cutaneous_collagen2.74076163
7MP0002837_dystrophic_cardiac_calcinosis2.57729691
8MP0010030_abnormal_orbit_morphology2.52866587
9MP0008932_abnormal_embryonic_tissue2.47143462
10MP0001188_hyperpigmentation2.37246268
11MP0001968_abnormal_touch/_nociception2.36708652
12MP0002876_abnormal_thyroid_physiology2.34777974
13MP0008875_abnormal_xenobiotic_pharmacok2.31545048
14MP0001542_abnormal_bone_strength2.30614060
15MP0003011_delayed_dark_adaptation2.22823423
16MP0008007_abnormal_cellular_replicative2.17058036
17MP0003136_yellow_coat_color2.16112987
18MP0003195_calcinosis2.15613523
19MP0005646_abnormal_pituitary_gland2.07802493
20MP0002736_abnormal_nociception_after2.07352116
21MP0005671_abnormal_response_to1.97044122
22MP0009250_abnormal_appendicular_skeleto1.94055570
23MP0009053_abnormal_anal_canal1.92038310
24MP0008872_abnormal_physiological_respon1.91232929
25MP0006072_abnormal_retinal_apoptosis1.88689100
26MP0005551_abnormal_eye_electrophysiolog1.84421361
27MP0004957_abnormal_blastocyst_morpholog1.81629004
28MP0005257_abnormal_intraocular_pressure1.77853883
29MP0004381_abnormal_hair_follicle1.77276931
30MP0008877_abnormal_DNA_methylation1.76830832
31MP0000685_abnormal_immune_system1.76335010
32MP0006036_abnormal_mitochondrial_physio1.74513742
33MP0005084_abnormal_gallbladder_morpholo1.71006692
34MP0002102_abnormal_ear_morphology1.69722952
35MP0004885_abnormal_endolymph1.66169189
36MP0002163_abnormal_gland_morphology1.66009107
37MP0000569_abnormal_digit_pigmentation1.64493564
38MP0010386_abnormal_urinary_bladder1.63292051
39MP0002132_abnormal_respiratory_system1.62524483
40MP0000049_abnormal_middle_ear1.60771809
41MP0001905_abnormal_dopamine_level1.59566822
42MP0005645_abnormal_hypothalamus_physiol1.58751099
43MP0003111_abnormal_nucleus_morphology1.57315084
44MP0001346_abnormal_lacrimal_gland1.56595331
45MP0003828_pulmonary_edema1.55971541
46MP0009745_abnormal_behavioral_response1.55349562
47MP0003693_abnormal_embryo_hatching1.52553383
48MP0002277_abnormal_respiratory_mucosa1.51958141
49MP0005389_reproductive_system_phenotype1.50745205
50MP0000681_abnormal_thyroid_gland1.46891224
51MP0009046_muscle_twitch1.46699823
52MP0002272_abnormal_nervous_system1.46072417
53MP0003656_abnormal_erythrocyte_physiolo1.44496034
54MP0010094_abnormal_chromosome_stability1.44014339
55MP0001790_abnormal_immune_system1.43293176
56MP0005387_immune_system_phenotype1.43293176
57MP0004185_abnormal_adipocyte_glucose1.42997683
58MP0001800_abnormal_humoral_immune1.42994163
59MP0001764_abnormal_homeostasis1.39987535
60MP0003718_maternal_effect1.39352987
61MP0005253_abnormal_eye_physiology1.38895505
62MP0002177_abnormal_outer_ear1.37780314
63MP0003385_abnormal_body_wall1.36991007
64MP0002148_abnormal_hypersensitivity_rea1.34670548
65MP0003786_premature_aging1.33256907
66MP0001835_abnormal_antigen_presentation1.32924746
67MP0002095_abnormal_skin_pigmentation1.29365250
68MP0000613_abnormal_salivary_gland1.28378790
69MP0005174_abnormal_tail_pigmentation1.27727981
70MP0000566_synostosis1.27281404
71MP0002928_abnormal_bile_duct1.26417435
72MP0005332_abnormal_amino_acid1.26393641
73MP0001919_abnormal_reproductive_system1.24936656
74MP0006292_abnormal_olfactory_placode1.24024442
75MP0005508_abnormal_skeleton_morphology1.23336185
76MP0005410_abnormal_fertilization1.21191497
77MP0009333_abnormal_splenocyte_physiolog1.20350704
78MP0003646_muscle_fatigue1.19667077
79MP0002933_joint_inflammation1.18710617
80MP0005423_abnormal_somatic_nervous1.17242595
81MP0009785_altered_susceptibility_to1.16856992
82MP0003938_abnormal_ear_development1.16093859
83MP0002064_seizures1.14779317
84MP0000678_abnormal_parathyroid_gland1.13980832
85MP0003186_abnormal_redox_activity1.12364563
86MP0008789_abnormal_olfactory_epithelium1.11355817
87MP0001663_abnormal_digestive_system1.10081527
88MP0005075_abnormal_melanosome_morpholog1.08966178
89MP0002693_abnormal_pancreas_physiology1.07029455
90MP0001756_abnormal_urination1.05206195
91MP0005248_abnormal_Harderian_gland1.04943490
92MP0002735_abnormal_chemical_nociception1.03296438
93MP0002452_abnormal_antigen_presenting1.03160768
94MP0008004_abnormal_stomach_pH1.03117320
95MP0002249_abnormal_larynx_morphology1.02671268
96MP0002638_abnormal_pupillary_reflex1.02006814
97MP0005501_abnormal_skin_physiology1.01468633
98MP0008058_abnormal_DNA_repair1.00692152
99MP0001970_abnormal_pain_threshold0.99772294
100MP0001873_stomach_inflammation0.99463072
101MP0005381_digestive/alimentary_phenotyp0.98693175
102MP0009764_decreased_sensitivity_to0.98354075
103MP0000490_abnormal_crypts_of0.97552269
104MP0009697_abnormal_copulation0.96733808
105MP0002723_abnormal_immune_serum0.96657539
106MP0004133_heterotaxia0.96059812
107MP0003315_abnormal_perineum_morphology0.95946571
108MP0003880_abnormal_central_pattern0.95945085
109MP0006276_abnormal_autonomic_nervous0.94884646
110MP0003077_abnormal_cell_cycle0.94653380
111MP0000372_irregular_coat_pigmentation0.91381576
112MP0001502_abnormal_circadian_rhythm0.90838054
113MP0004742_abnormal_vestibular_system0.89968001
114MP0005636_abnormal_mineral_homeostasis0.89448642
115MP0001501_abnormal_sleep_pattern0.89175222
116MP0002060_abnormal_skin_morphology0.89046442
117MP0001944_abnormal_pancreas_morphology0.88897614
118MP0003252_abnormal_bile_duct0.87891491
119MP0005595_abnormal_vascular_smooth0.87335158
120MP0001986_abnormal_taste_sensitivity0.86042151
121MP0005390_skeleton_phenotype0.85311210
122MP0005409_darkened_coat_color0.85268799
123MP0001486_abnormal_startle_reflex0.85099733
124MP0000538_abnormal_urinary_bladder0.84734500
125MP0000516_abnormal_urinary_system0.84030064
126MP0005367_renal/urinary_system_phenotyp0.84030064
127MP0002653_abnormal_ependyma_morphology0.83886161
128MP0002938_white_spotting0.83750179
129MP0003755_abnormal_palate_morphology0.83707194
130MP0002420_abnormal_adaptive_immunity0.83578460
131MP0010771_integument_phenotype0.83277645
132MP0000427_abnormal_hair_cycle0.83235206
133MP0002733_abnormal_thermal_nociception0.83189699
134MP0005220_abnormal_exocrine_pancreas0.82306133
135MP0001819_abnormal_immune_cell0.81630421
136MP0000762_abnormal_tongue_morphology0.81205539
137MP0005503_abnormal_tendon_morphology0.81143569
138MP0000467_abnormal_esophagus_morphology0.80562809
139MP0005000_abnormal_immune_tolerance0.80479242
140MP0003868_abnormal_feces_composition0.79912167
141MP0002796_impaired_skin_barrier0.79652414
142MP0004019_abnormal_vitamin_homeostasis0.77825703
143MP0002572_abnormal_emotion/affect_behav0.76987367
144MP0004147_increased_porphyrin_level0.74709107
145MP0002138_abnormal_hepatobiliary_system0.74563988
146MP0005394_taste/olfaction_phenotype0.74542222
147MP0005499_abnormal_olfactory_system0.74542222
148MP0005379_endocrine/exocrine_gland_phen0.74440698
149MP0001485_abnormal_pinna_reflex0.73512018
150MP0000631_abnormal_neuroendocrine_gland0.73322717
151MP0003436_decreased_susceptibility_to0.72746210
152MP0002098_abnormal_vibrissa_morphology0.72554428
153MP0000858_altered_metastatic_potential0.71265374
154MP0001286_abnormal_eye_development0.71183827
155MP0008961_abnormal_basal_metabolism0.70705289
156MP0004145_abnormal_muscle_electrophysio0.70364062
157MP0002067_abnormal_sensory_capabilities0.70277232
158MP0005310_abnormal_salivary_gland0.70242175
159MP0001765_abnormal_ion_homeostasis0.69777452
160MP0001963_abnormal_hearing_physiology0.68688543
161MP0004043_abnormal_pH_regulation0.68658385
162MP0004142_abnormal_muscle_tone0.67834691
163MP0000350_abnormal_cell_proliferation0.67522363
164MP0002210_abnormal_sex_determination0.67494031
165MP0000015_abnormal_ear_pigmentation0.66000478
166MP0003763_abnormal_thymus_physiology0.64882616
167MP0003448_altered_tumor_morphology0.64686225
168MP0001243_abnormal_dermal_layer0.64665953
169MP0002160_abnormal_reproductive_system0.64560213
170MP0000026_abnormal_inner_ear0.64437118
171MP0002932_abnormal_joint_morphology0.63954533
172MP0002877_abnormal_melanocyte_morpholog0.61504705
173MP0003300_gastrointestinal_ulcer0.58801982

Predicted human phenotypes

RankGene SetZ-score
1Abnormal hemoglobin (HP:0011902)6.21987091
2Premature rupture of membranes (HP:0001788)5.90746119
3Reticulocytopenia (HP:0001896)5.15124263
4Macrocytic anemia (HP:0001972)5.00596207
5Concave nail (HP:0001598)4.91725027
6Aplasia/Hypoplasia of the sacrum (HP:0008517)4.87847970
7Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.93682593
8Pallor (HP:0000980)3.87550714
9Congenital sensorineural hearing impairment (HP:0008527)3.82380496
10Obstructive sleep apnea (HP:0002870)3.80778485
11Methylmalonic acidemia (HP:0002912)3.57678456
12Protrusio acetabuli (HP:0003179)3.55263629
13Congenital, generalized hypertrichosis (HP:0004540)3.52802097
14Increased hepatocellular lipid droplets (HP:0006565)3.51899829
15Abnormal number of erythroid precursors (HP:0012131)3.48979577
16Progressive macrocephaly (HP:0004481)3.47392218
17Abnormality of dental color (HP:0011073)3.40611026
18Pancreatic cysts (HP:0001737)3.37175112
19Exertional dyspnea (HP:0002875)3.34640510
20Soft skin (HP:0000977)3.32899323
21Hepatocellular necrosis (HP:0001404)3.31545295
22Congenital stationary night blindness (HP:0007642)3.29551086
23Molar tooth sign on MRI (HP:0002419)3.27645848
24Abnormality of midbrain morphology (HP:0002418)3.27645848
25Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.22669380
26Abnormality of cells of the erythroid lineage (HP:0012130)3.19772235
27Acute encephalopathy (HP:0006846)3.16967742
28Sparse lateral eyebrow (HP:0005338)3.16885449
29Triphalangeal thumb (HP:0001199)3.15550954
30Methylmalonic aciduria (HP:0012120)3.15393770
31Redundant skin (HP:0001582)3.08126962
32Nephronophthisis (HP:0000090)3.06468013
33Mitochondrial inheritance (HP:0001427)3.00753878
34Lipid accumulation in hepatocytes (HP:0006561)2.97391418
35Renal Fanconi syndrome (HP:0001994)2.91704625
36Biconcave vertebral bodies (HP:0004586)2.86153228
37Seborrheic dermatitis (HP:0001051)2.78323361
38Attenuation of retinal blood vessels (HP:0007843)2.74358466
39Achilles tendon contracture (HP:0001771)2.73533357
40Pancreatic fibrosis (HP:0100732)2.70422647
41Abnormal pupillary function (HP:0007686)2.68430643
42Progressive external ophthalmoplegia (HP:0000590)2.66744593
43Decreased activity of mitochondrial respiratory chain (HP:0008972)2.63017559
44Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.63017559
45Pendular nystagmus (HP:0012043)2.62437948
46Breast hypoplasia (HP:0003187)2.62026328
47True hermaphroditism (HP:0010459)2.61215339
48Secondary amenorrhea (HP:0000869)2.59790958
49Hepatic necrosis (HP:0002605)2.51620765
50Abnormality of the renal cortex (HP:0011035)2.51336659
51Down-sloping shoulders (HP:0200021)2.50323953
52Increased intramyocellular lipid droplets (HP:0012240)2.49637020
53Testicular atrophy (HP:0000029)2.48776272
54Trismus (HP:0000211)2.48055478
55Abnormality of the renal medulla (HP:0100957)2.46500279
56Hyperphosphaturia (HP:0003109)2.43539987
57Depressed nasal ridge (HP:0000457)2.43471034
58Horseshoe kidney (HP:0000085)2.42642268
59Hypoparathyroidism (HP:0000829)2.41784283
60Fragile nails (HP:0001808)2.39009320
61Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.38547453
62Abnormality of alanine metabolism (HP:0010916)2.38547453
63Hyperalaninemia (HP:0003348)2.38547453
64IgG deficiency (HP:0004315)2.37329995
65Optic disc pallor (HP:0000543)2.36325190
66Abnormality of the Achilles tendon (HP:0005109)2.35414530
67Abnormality of homocysteine metabolism (HP:0010919)2.31902433
68Homocystinuria (HP:0002156)2.31902433
69Renal cortical cysts (HP:0000803)2.31840292
70Sleep apnea (HP:0010535)2.30516177
71Glycosuria (HP:0003076)2.28175808
72Abnormality of urine glucose concentration (HP:0011016)2.28175808
73Woolly hair (HP:0002224)2.26169962
74Chronic hepatic failure (HP:0100626)2.25530591
75Obstructive lung disease (HP:0006536)2.25469310
76Chronic obstructive pulmonary disease (HP:0006510)2.25469310
77Increased CSF lactate (HP:0002490)2.25262461
78Polydipsia (HP:0001959)2.22095620
79Abnormal drinking behavior (HP:0030082)2.22095620
80Unilateral renal agenesis (HP:0000122)2.20796551
81Cerebral edema (HP:0002181)2.20293459
82Rib fusion (HP:0000902)2.19834552
83Decreased electroretinogram (ERG) amplitude (HP:0000654)2.19773244
84Lactic acidosis (HP:0003128)2.18871234
85Abnormality of vitamin B metabolism (HP:0004340)2.18649547
86Vertebral compression fractures (HP:0002953)2.16198067
87Aplasia/hypoplasia of the uterus (HP:0008684)2.15410393
88Confusion (HP:0001289)2.14966032
89Type I transferrin isoform profile (HP:0003642)2.14730400
90Sparse eyelashes (HP:0000653)2.12008886
91Rough bone trabeculation (HP:0100670)2.11272180
92Hypoplasia of the pons (HP:0012110)2.10420931
93Abnormal albumin level (HP:0012116)2.10348188
94Hypoalbuminemia (HP:0003073)2.10348188
95Increased serum lactate (HP:0002151)2.10049766
96Hypertensive crisis (HP:0100735)2.09395521
97Abnormal rod and cone electroretinograms (HP:0008323)2.09014395
98Abnormality of aspartate family amino acid metabolism (HP:0010899)2.08431444
99Microglossia (HP:0000171)2.06302242
100Amniotic constriction ring (HP:0009775)2.05762559
101Abnormality of placental membranes (HP:0011409)2.05762559
102Decreased central vision (HP:0007663)2.04858549
103Hypothermia (HP:0002045)2.04842164
104Abnormality of the vitamin B12 metabolism (HP:0004341)2.04350416
105Microvesicular hepatic steatosis (HP:0001414)2.03137478
106Absent thumb (HP:0009777)2.01334173
107Abnormality of the pons (HP:0007361)2.01151455
108Flat occiput (HP:0005469)2.00453649
109Submucous cleft hard palate (HP:0000176)2.00305101
110Hyperthyroidism (HP:0000836)1.98125541
111Abnormality of methionine metabolism (HP:0010901)1.96743469
112Respiratory failure (HP:0002878)1.95780287
113Hypophosphatemic rickets (HP:0004912)1.95436589
114Chin dimple (HP:0010751)1.94955339
115Abolished electroretinogram (ERG) (HP:0000550)1.94682942
116Neonatal short-limb short stature (HP:0008921)1.93971985
117Increased muscle lipid content (HP:0009058)1.93803767
118Abnormal delivery (HP:0001787)1.93314432
119Furrowed tongue (HP:0000221)1.92364617
120Generalized aminoaciduria (HP:0002909)1.91747441
121Lethargy (HP:0001254)1.91481256
122Tracheomalacia (HP:0002779)1.91431178
123Adrenal hypoplasia (HP:0000835)1.91415914
124Acute necrotizing encephalopathy (HP:0006965)1.91311150
125Entropion (HP:0000621)1.90717117
126Overgrowth (HP:0001548)1.89973029
127Large for gestational age (HP:0001520)1.89590575
128Fragile skin (HP:0001030)1.89293173
129Nuclear cataract (HP:0100018)1.87644043
130Leukodystrophy (HP:0002415)1.86565645
131Aplasia involving bones of the upper limbs (HP:0009823)1.86464056
132Aplasia of the phalanges of the hand (HP:0009802)1.86464056
133Aplasia involving bones of the extremities (HP:0009825)1.86464056
134Ridged nail (HP:0001807)1.85701380
135Abnormal protein glycosylation (HP:0012346)1.85232853
136Abnormal glycosylation (HP:0012345)1.85232853
137Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.85232853
138Abnormal protein N-linked glycosylation (HP:0012347)1.85232853
139Deep palmar crease (HP:0006191)1.84814505
140Medial flaring of the eyebrow (HP:0010747)1.83498621
141Type II lissencephaly (HP:0007260)1.82493877
142Oligodactyly (HP:0012165)1.81941190
143Upper limb muscle weakness (HP:0003484)1.81102519
144Curly hair (HP:0002212)1.80289463
145Tubular atrophy (HP:0000092)1.80223680
146Abnormality of serum amino acid levels (HP:0003112)1.79485834
1473-Methylglutaconic aciduria (HP:0003535)1.79007587
148Abnormal urine phosphate concentration (HP:0012599)1.78813978
149Hypoplasia of the radius (HP:0002984)1.77500776
150Abnormality of renal resorption (HP:0011038)1.76506019
151Polyuria (HP:0000103)1.75409358
152Morphological abnormality of the middle ear (HP:0008609)1.75166469
153Cleft eyelid (HP:0000625)1.74379350
154Dicarboxylic aciduria (HP:0003215)1.73974079
155Abnormality of dicarboxylic acid metabolism (HP:0010995)1.73974079
156Chorioretinal atrophy (HP:0000533)1.73453349
157Abnormal mitochondria in muscle tissue (HP:0008316)1.72283341
158Bony spicule pigmentary retinopathy (HP:0007737)1.72179462
159Absent rod-and cone-mediated responses on ERG (HP:0007688)1.72141528
160Thick lower lip vermilion (HP:0000179)1.72086822
161Tinnitus (HP:0000360)1.71603300
162Conjunctival hamartoma (HP:0100780)1.71588006
163Male pseudohermaphroditism (HP:0000037)1.70875948
164Megalencephaly (HP:0001355)1.69929257
165Progressive muscle weakness (HP:0003323)1.69185062
166Cerebral hypomyelination (HP:0006808)1.68883481
167Microcytic anemia (HP:0001935)1.68295922
168Sclerocornea (HP:0000647)1.68012537
169Respiratory difficulties (HP:0002880)1.67590509
170Gaze-evoked nystagmus (HP:0000640)1.65635912
171Cystic liver disease (HP:0006706)1.65609070

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK18.05006222
2EIF2AK15.79010086
3FRK3.89990445
4NME23.43725976
5CDK193.39422687
6BUB12.86393536
7ZAK2.80509170
8MKNK22.73717383
9FES2.72778985
10NEK92.72564679
11CASK2.65874176
12ADRBK22.61639339
13GRK12.49005416
14TESK22.44723907
15VRK22.40527980
16TAOK32.26045693
17SRPK12.17376029
18MAP4K22.12058424
19PBK1.88894980
20INSRR1.88507527
21OXSR11.77360980
22WNK41.75781929
23PIM21.69953462
24STK161.64286063
25ACVR1B1.60911289
26PHKG11.55459973
27PHKG21.55459973
28FER1.53399054
29MKNK11.52988929
30IRAK11.50776234
31WNK31.42372944
32IRAK41.41216460
33CDK81.40987838
34DMPK1.40252924
35CLK11.37865814
36PRKD21.34186756
37PINK11.32133614
38DYRK1B1.30356120
39MAP3K121.29641786
40BLK1.28961983
41IRAK31.28658087
42NUAK11.27725016
43WEE11.25393165
44NME11.24725005
45IRAK21.18387449
46GRK61.16183169
47DAPK21.14857419
48VRK11.05392891
49TAF11.04869032
50MAP3K111.01202882
51CDK91.00063289
52MAPK130.95933703
53CAMKK20.95739767
54TNK20.95132980
55NLK0.93343781
56SYK0.92842069
57MAP2K70.92743626
58DYRK30.92356317
59TEC0.89214493
60DAPK30.87233081
61STK380.85706764
62PLK40.85656625
63AURKA0.84749948
64BCKDK0.84643500
65PKN10.82799169
66CSK0.82077282
67EPHB20.80932335
68PLK10.80897032
69KIT0.80181285
70LIMK10.78070866
71CDK70.76631558
72MAP2K60.74923502
73EIF2AK30.72035655
74PAK30.68446396
75MAP4K10.65392343
76HIPK20.64662461
77BRSK20.64658470
78PRKCQ0.61900865
79TNIK0.61594900
80TIE10.60920096
81PRKCI0.60863470
82EIF2AK20.60773897
83YES10.60360645
84DYRK20.60056192
85PRPF4B0.58067881
86STK40.57910271
87UHMK10.57366421
88AURKB0.56808014
89RPS6KA60.55502838
90PRKCE0.54945291
91PLK20.54333977
92ADRBK10.53952333
93ERBB20.53788776
94CHUK0.53221504
95ABL20.52350516
96RPS6KB20.52039195
97TTK0.51733567
98CSNK1G10.51650358
99PRKCG0.51437208
100GRK50.51020890
101CSNK1G30.50950899
102BRAF0.49035159
103PAK40.48760383
104CDK140.47688971
105TGFBR10.47578335
106ITK0.46689500
107STK390.46504448
108PRKACA0.45622545
109CSNK1G20.45318460
110CSNK2A10.44676764
111IKBKE0.44638291
112MINK10.43399800
113MYLK0.42798517
114PRKG10.41877532
115CCNB10.41782029
116MST40.41651794
117LYN0.40401168
118RPS6KA50.40310921
119DDR20.40180101
120STK110.39805796
121LCK0.39032897
122BTK0.38638211
123PLK30.37747870
124CSNK2A20.37589873
125EPHA30.37231928
126PRKCA0.36880613
127CAMK2B0.35267933
128MUSK0.34282566
129STK38L0.33280140
130CDK11A0.32811806
131PASK0.32638309
132GRK70.32457610
133PTK2B0.32087433
134FLT30.31781736
135TBK10.31262874
136CHEK20.29030738
137MAPK40.28781246
138TXK0.28059621
139TESK10.27704570
140MAPK110.27633846
141BMPR1B0.25304462
142MAPKAPK50.24831380
143NEK20.24119353
144CAMK2D0.23965213
145DYRK1A0.23761510
146RPS6KA40.23758708
147CDC70.23631973
148MAPK150.21030443
149MAP3K80.20997724
150IKBKB0.19413791
151ATM0.18756941
152CSNK1A10.18459706
153ILK0.18008652
154PRKDC0.17242232
155PIM10.17207639
156TSSK60.17160347
157CDK60.17110486

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.01422529
2Protein export_Homo sapiens_hsa030604.25201483
3RNA polymerase_Homo sapiens_hsa030203.52702172
4Sulfur relay system_Homo sapiens_hsa041223.29695196
5Homologous recombination_Homo sapiens_hsa034403.12800493
6DNA replication_Homo sapiens_hsa030302.96854620
7Spliceosome_Homo sapiens_hsa030402.41216819
8One carbon pool by folate_Homo sapiens_hsa006702.27059589
9Basal transcription factors_Homo sapiens_hsa030222.24475608
10Cyanoamino acid metabolism_Homo sapiens_hsa004602.12319207
11Asthma_Homo sapiens_hsa053102.03047185
12Mismatch repair_Homo sapiens_hsa034302.01298594
13Pyrimidine metabolism_Homo sapiens_hsa002401.99802339
14Fanconi anemia pathway_Homo sapiens_hsa034601.95247373
15Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.94109776
16Vitamin B6 metabolism_Homo sapiens_hsa007501.91144118
17Oxidative phosphorylation_Homo sapiens_hsa001901.84985024
18Nucleotide excision repair_Homo sapiens_hsa034201.83739002
19Base excision repair_Homo sapiens_hsa034101.83458699
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.80602529
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.75418043
22Parkinsons disease_Homo sapiens_hsa050121.74920575
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.63919464
24Allograft rejection_Homo sapiens_hsa053301.58392081
25Proteasome_Homo sapiens_hsa030501.57168908
26Collecting duct acid secretion_Homo sapiens_hsa049661.53205711
27Folate biosynthesis_Homo sapiens_hsa007901.48367609
28Type I diabetes mellitus_Homo sapiens_hsa049401.47290751
29Cell cycle_Homo sapiens_hsa041101.44894465
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.43793137
31Graft-versus-host disease_Homo sapiens_hsa053321.40718534
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.40647287
33Huntingtons disease_Homo sapiens_hsa050161.37691485
34mRNA surveillance pathway_Homo sapiens_hsa030151.35079633
35RNA transport_Homo sapiens_hsa030131.34621793
36Bladder cancer_Homo sapiens_hsa052191.32516494
37Sulfur metabolism_Homo sapiens_hsa009201.28767223
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.26176627
39Chemical carcinogenesis_Homo sapiens_hsa052041.25975738
40Linoleic acid metabolism_Homo sapiens_hsa005911.17807941
41Caffeine metabolism_Homo sapiens_hsa002321.14458837
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.14375835
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.14060941
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13237273
45Systemic lupus erythematosus_Homo sapiens_hsa053221.12747711
46Thyroid cancer_Homo sapiens_hsa052161.11722607
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.07349320
48Rheumatoid arthritis_Homo sapiens_hsa053231.04355794
49Nitrogen metabolism_Homo sapiens_hsa009101.03875829
50Herpes simplex infection_Homo sapiens_hsa051681.03034459
51Alzheimers disease_Homo sapiens_hsa050101.01109751
52Regulation of autophagy_Homo sapiens_hsa041401.00987111
53Tryptophan metabolism_Homo sapiens_hsa003800.98859648
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98237419
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.97976200
56Purine metabolism_Homo sapiens_hsa002300.96172454
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91362660
58Nicotine addiction_Homo sapiens_hsa050330.91020112
59Other glycan degradation_Homo sapiens_hsa005110.89543767
60p53 signaling pathway_Homo sapiens_hsa041150.89192760
61Butanoate metabolism_Homo sapiens_hsa006500.88567137
62Vitamin digestion and absorption_Homo sapiens_hsa049770.86256724
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.85417069
64Non-homologous end-joining_Homo sapiens_hsa034500.84177592
65Epstein-Barr virus infection_Homo sapiens_hsa051690.81180531
66Sphingolipid metabolism_Homo sapiens_hsa006000.80965432
67Mineral absorption_Homo sapiens_hsa049780.80925876
68Selenocompound metabolism_Homo sapiens_hsa004500.78934123
69RNA degradation_Homo sapiens_hsa030180.74721579
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.74369608
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73436022
72Melanoma_Homo sapiens_hsa052180.69895501
73Oocyte meiosis_Homo sapiens_hsa041140.65524951
74Alcoholism_Homo sapiens_hsa050340.65454573
75Peroxisome_Homo sapiens_hsa041460.65258832
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63892668
77Malaria_Homo sapiens_hsa051440.63738443
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.63642391
79Arachidonic acid metabolism_Homo sapiens_hsa005900.63522979
80Antigen processing and presentation_Homo sapiens_hsa046120.63386214
81Hematopoietic cell lineage_Homo sapiens_hsa046400.62472612
82Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61627326
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60920323
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60188319
85Taste transduction_Homo sapiens_hsa047420.59054268
86Wnt signaling pathway_Homo sapiens_hsa043100.54439167
87Morphine addiction_Homo sapiens_hsa050320.53591901
88Phototransduction_Homo sapiens_hsa047440.50433614
89Primary immunodeficiency_Homo sapiens_hsa053400.49730674
90Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49241989
91HTLV-I infection_Homo sapiens_hsa051660.48878448
92Basal cell carcinoma_Homo sapiens_hsa052170.45865565
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45102672
94Olfactory transduction_Homo sapiens_hsa047400.44031438
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43955912
96Long-term depression_Homo sapiens_hsa047300.43843908
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42950072
98Prostate cancer_Homo sapiens_hsa052150.42930252
99Hepatitis B_Homo sapiens_hsa051610.40739643
100Acute myeloid leukemia_Homo sapiens_hsa052210.40593878
101Propanoate metabolism_Homo sapiens_hsa006400.38841978
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38339522
103Glioma_Homo sapiens_hsa052140.37323049
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37312524
105Staphylococcus aureus infection_Homo sapiens_hsa051500.37286313
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36559300
107NF-kappa B signaling pathway_Homo sapiens_hsa040640.35937862
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.34470986
109Cardiac muscle contraction_Homo sapiens_hsa042600.32965926
110Melanogenesis_Homo sapiens_hsa049160.32612972
111Shigellosis_Homo sapiens_hsa051310.32211879
112Insulin secretion_Homo sapiens_hsa049110.31897648
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31276868
114Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29246009
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.28405234
116Measles_Homo sapiens_hsa051620.27889680
117TGF-beta signaling pathway_Homo sapiens_hsa043500.27312203
118Hippo signaling pathway_Homo sapiens_hsa043900.26992013
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26567379
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26434268
121Hepatitis C_Homo sapiens_hsa051600.26268706
122Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25248303
123Glycerolipid metabolism_Homo sapiens_hsa005610.25028096
124Serotonergic synapse_Homo sapiens_hsa047260.24812247
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.24782031
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24408876
127Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.24013479
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.23830852
129Intestinal immune network for IgA production_Homo sapiens_hsa046720.23782838
130Glutathione metabolism_Homo sapiens_hsa004800.23714902
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23310012
132Retinol metabolism_Homo sapiens_hsa008300.22169441
133MicroRNAs in cancer_Homo sapiens_hsa052060.21409895
134Fatty acid degradation_Homo sapiens_hsa000710.21371764
135African trypanosomiasis_Homo sapiens_hsa051430.21328257
136Metabolic pathways_Homo sapiens_hsa011000.21290986
137Maturity onset diabetes of the young_Homo sapiens_hsa049500.21209451
138Tight junction_Homo sapiens_hsa045300.19202946
139Autoimmune thyroid disease_Homo sapiens_hsa053200.19028533
140Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.18263475
141Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17608141
142Vibrio cholerae infection_Homo sapiens_hsa051100.16862961
143beta-Alanine metabolism_Homo sapiens_hsa004100.16734527
144Circadian entrainment_Homo sapiens_hsa047130.16647204
145Calcium signaling pathway_Homo sapiens_hsa040200.16211593
146Leukocyte transendothelial migration_Homo sapiens_hsa046700.16147086
147Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15579713
148Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.13911831
149Ether lipid metabolism_Homo sapiens_hsa005650.13291083
150Chronic myeloid leukemia_Homo sapiens_hsa052200.12880884

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