SNX24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)4.02552189
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.02552189
3platelet dense granule organization (GO:0060155)3.81638242
4central nervous system myelination (GO:0022010)3.69148271
5axon ensheathment in central nervous system (GO:0032291)3.69148271
6regulation of meiosis I (GO:0060631)3.66320898
7L-phenylalanine metabolic process (GO:0006558)3.61165104
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.61165104
9proteasome assembly (GO:0043248)3.54313831
10negative regulation of complement activation (GO:0045916)3.35462301
11fatty acid elongation (GO:0030497)3.32342978
12negative regulation of protein activation cascade (GO:2000258)3.26235695
13coenzyme catabolic process (GO:0009109)3.15541313
14limb bud formation (GO:0060174)3.12326087
15high-density lipoprotein particle remodeling (GO:0034375)3.11191293
16water-soluble vitamin biosynthetic process (GO:0042364)3.03363787
17negative regulation of fibrinolysis (GO:0051918)3.03134958
18homocysteine metabolic process (GO:0050667)3.01012651
19negative regulation of axon extension involved in axon guidance (GO:0048843)2.99819325
20aldehyde catabolic process (GO:0046185)2.98243296
21keratinocyte development (GO:0003334)2.90593526
22negative regulation of axon guidance (GO:1902668)2.90223851
23respiratory chain complex IV assembly (GO:0008535)2.89586641
24ganglion development (GO:0061548)2.87593979
25regulation of fibrinolysis (GO:0051917)2.87186564
26peptidyl-cysteine modification (GO:0018198)2.82195162
27axonal fasciculation (GO:0007413)2.80276747
28reverse cholesterol transport (GO:0043691)2.79555801
29positive regulation of meiosis (GO:0045836)2.77354209
30aromatic amino acid family catabolic process (GO:0009074)2.76238941
31response to pheromone (GO:0019236)2.73762780
32glutamine family amino acid biosynthetic process (GO:0009084)2.72922538
33regulation of mitochondrial translation (GO:0070129)2.72765804
34glycerophospholipid catabolic process (GO:0046475)2.72755044
35regulation of hexokinase activity (GO:1903299)2.69512082
36regulation of glucokinase activity (GO:0033131)2.69512082
37dicarboxylic acid catabolic process (GO:0043649)2.68200685
38prenylation (GO:0097354)2.65765402
39protein prenylation (GO:0018342)2.65765402
40response to redox state (GO:0051775)2.65475899
41midgut development (GO:0007494)2.65165227
42cerebral cortex radially oriented cell migration (GO:0021799)2.61704769
43mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.60746888
44epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.60368838
45positive regulation of meiotic cell cycle (GO:0051446)2.60095642
46lactate metabolic process (GO:0006089)2.60082501
47regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.59435343
48intraciliary transport (GO:0042073)2.57088946
49somite development (GO:0061053)2.54507023
50protein neddylation (GO:0045116)2.54417560
51positive regulation of protein autophosphorylation (GO:0031954)2.53391497
52regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.53072604
53regulation of neuron projection regeneration (GO:0070570)2.52161243
54regulation of axon regeneration (GO:0048679)2.52161243
55protein heterotetramerization (GO:0051290)2.51320918
56phospholipid homeostasis (GO:0055091)2.50969531
57cytochrome complex assembly (GO:0017004)2.50064915
58positive regulation of actin filament depolymerization (GO:0030836)2.49850649
59presynaptic membrane assembly (GO:0097105)2.49005382
60establishment of protein localization to mitochondrial membrane (GO:0090151)2.48253034
61tyrosine metabolic process (GO:0006570)2.47919987
62righting reflex (GO:0060013)2.46938384
63cofactor catabolic process (GO:0051187)2.46834485
64cholesterol efflux (GO:0033344)2.46479433
65regulation of male gonad development (GO:2000018)2.46284510
66presynaptic membrane organization (GO:0097090)2.45223972
67regulation of lipoprotein metabolic process (GO:0050746)2.44728727
68piRNA metabolic process (GO:0034587)2.43408784
69negative regulation of neurotransmitter secretion (GO:0046929)2.43315722
70positive regulation of oligodendrocyte differentiation (GO:0048714)2.42768861
71negative regulation of stem cell proliferation (GO:2000647)2.42429870
72nonmotile primary cilium assembly (GO:0035058)2.40366914
73regulation of protein activation cascade (GO:2000257)2.40149443
74regulation of pigment cell differentiation (GO:0050932)2.39682507
75COPII vesicle coating (GO:0048208)2.39354565
76female gonad development (GO:0008585)2.36997336
77cellular ketone body metabolic process (GO:0046950)2.36454443
78protein complex biogenesis (GO:0070271)2.36330547
79neuron recognition (GO:0008038)2.35648791
80very-low-density lipoprotein particle assembly (GO:0034379)2.35158510
81myelination (GO:0042552)2.35008006
82C-terminal protein lipidation (GO:0006501)2.34177803
83epithelial cilium movement (GO:0003351)2.34087151
84chromatin remodeling at centromere (GO:0031055)2.33035250
85regulation of complement activation (GO:0030449)2.32980827
86axon ensheathment (GO:0008366)2.31692732
87ensheathment of neurons (GO:0007272)2.31692732
88CENP-A containing nucleosome assembly (GO:0034080)2.30679091
89Golgi transport vesicle coating (GO:0048200)2.29757004
90COPI coating of Golgi vesicle (GO:0048205)2.29757004
91response to gravity (GO:0009629)2.29189116
92cardiac right ventricle morphogenesis (GO:0003215)2.28524961
93protein-lipid complex remodeling (GO:0034368)2.28151987
94macromolecular complex remodeling (GO:0034367)2.28151987
95plasma lipoprotein particle remodeling (GO:0034369)2.28151987
96negative regulation of protein localization to cell surface (GO:2000009)2.28038065
97ATP hydrolysis coupled proton transport (GO:0015991)2.27246622
98energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.27246622
99regulation of sulfur metabolic process (GO:0042762)2.26005443
100embryonic foregut morphogenesis (GO:0048617)2.25282580
101protein K11-linked ubiquitination (GO:0070979)2.24799398
102plasma lipoprotein particle clearance (GO:0034381)2.24075229
103branched-chain amino acid catabolic process (GO:0009083)2.23583852
104mitotic metaphase plate congression (GO:0007080)2.21769628
105regulation of acyl-CoA biosynthetic process (GO:0050812)2.21679212
106C-terminal protein amino acid modification (GO:0018410)2.21453373
107neuron projection extension involved in neuron projection guidance (GO:1902284)2.20791270
108axon extension involved in axon guidance (GO:0048846)2.20791270
109protein K6-linked ubiquitination (GO:0085020)2.20367244
110neuron remodeling (GO:0016322)2.20091974
111negative regulation of neurotransmitter transport (GO:0051589)2.20087218
112protein maturation by protein folding (GO:0022417)2.20048307
113cerebral cortex cell migration (GO:0021795)2.19861213
114cilium morphogenesis (GO:0060271)2.19685184
115cerebellar granule cell differentiation (GO:0021707)2.18762220
116negative regulation of DNA-dependent DNA replication (GO:2000104)2.17401133
117maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.17331180
1187-methylguanosine mRNA capping (GO:0006370)2.16474226
119gamma-aminobutyric acid transport (GO:0015812)2.15726745
120prostate gland growth (GO:0060736)2.14985211
121regulation of coenzyme metabolic process (GO:0051196)2.13868163
122regulation of cofactor metabolic process (GO:0051193)2.13868163
123ER overload response (GO:0006983)2.13179554
124peptidyl-glutamic acid carboxylation (GO:0017187)2.13007930
125protein carboxylation (GO:0018214)2.13007930
126cholesterol biosynthetic process (GO:0006695)2.12873490
127positive regulation of glycoprotein metabolic process (GO:1903020)2.12335555
128purine nucleotide transport (GO:0015865)2.12268321
129positive regulation of glycoprotein biosynthetic process (GO:0010560)2.12008355
130neuronal action potential propagation (GO:0019227)2.11997829
131mitochondrial respiratory chain complex assembly (GO:0033108)2.11417089
132long-chain fatty acid biosynthetic process (GO:0042759)2.10735935
133photoreceptor cell differentiation (GO:0046530)2.10483037
134eye photoreceptor cell differentiation (GO:0001754)2.10483037
1357-methylguanosine RNA capping (GO:0009452)2.09591647
136RNA capping (GO:0036260)2.09591647
137establishment of integrated proviral latency (GO:0075713)2.09576101
138chaperone-mediated protein transport (GO:0072321)2.09062023
139metaphase plate congression (GO:0051310)2.08712792
140L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.08580538
141regulation of non-canonical Wnt signaling pathway (GO:2000050)2.08553692
142dendrite morphogenesis (GO:0048813)2.08552488
143mitotic sister chromatid cohesion (GO:0007064)2.08044982
144kinetochore organization (GO:0051383)2.07965250
145forebrain neuron development (GO:0021884)2.07856713
146zinc ion transport (GO:0006829)2.07835688
147somite rostral/caudal axis specification (GO:0032525)2.07805069
148histone exchange (GO:0043486)2.07663425
149cilium assembly (GO:0042384)2.06892289
150photoreceptor cell maintenance (GO:0045494)2.06763457
151purine ribonucleotide transport (GO:0015868)2.06679509
152oligodendrocyte differentiation (GO:0048709)2.06587251
153positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.05894277
154negative regulation of activin receptor signaling pathway (GO:0032926)2.04775265
155opsonization (GO:0008228)2.04339893
156glutathione derivative metabolic process (GO:1901685)2.04280004
157glutathione derivative biosynthetic process (GO:1901687)2.04280004
158transferrin transport (GO:0033572)2.04106907
159nucleotide transmembrane transport (GO:1901679)2.03606478
160replication fork processing (GO:0031297)2.02939041
161regulation of energy homeostasis (GO:2000505)2.02587105
162ketone body metabolic process (GO:1902224)2.02583583
163regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.01988406
164regulation of acrosome reaction (GO:0060046)2.01915484
165anterograde synaptic vesicle transport (GO:0048490)2.01756395
166cilium organization (GO:0044782)2.01645833
167vitamin biosynthetic process (GO:0009110)2.01396779
168regulation of integrin-mediated signaling pathway (GO:2001044)2.01331066
169nodal signaling pathway (GO:0038092)2.00680562
170synapsis (GO:0007129)2.00564142
171triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.00443106
172sphingomyelin metabolic process (GO:0006684)2.00415032
173transcription elongation from RNA polymerase III promoter (GO:0006385)1.99786385
174termination of RNA polymerase III transcription (GO:0006386)1.99786385
175ventricular cardiac muscle cell development (GO:0055015)1.99559701
176peptidyl-histidine modification (GO:0018202)1.99538816
177negative regulation of phosphoprotein phosphatase activity (GO:0032515)1.99527230
178positive regulation of smooth muscle cell migration (GO:0014911)1.99232938
179gamma-aminobutyric acid signaling pathway (GO:0007214)1.99201064
180negative regulation of axon extension (GO:0030517)1.98660500
181urinary tract smooth muscle contraction (GO:0014848)1.98550816
182ferric iron transport (GO:0015682)1.98333034
183trivalent inorganic cation transport (GO:0072512)1.98333034
184negative regulation of keratinocyte proliferation (GO:0010839)1.97921751
185pyrimidine nucleobase catabolic process (GO:0006208)1.97878576
186male meiosis I (GO:0007141)1.97825570
187regulation of cardioblast differentiation (GO:0051890)1.96418772
188spindle assembly involved in mitosis (GO:0090307)1.95071708
189anterior/posterior axis specification, embryo (GO:0008595)1.94570082
190histone H2A acetylation (GO:0043968)1.94523864

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.52639485
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.06287998
3EZH2_22144423_ChIP-Seq_EOC_Human2.79600052
4GABP_17652178_ChIP-ChIP_JURKAT_Human2.39154191
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.36356899
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.17866937
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.15369472
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.10985095
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.09519526
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.08524930
11ELK1_19687146_ChIP-ChIP_HELA_Human2.03684415
12RBPJ_22232070_ChIP-Seq_NCS_Mouse1.98940978
13* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.97443391
14EED_16625203_ChIP-ChIP_MESCs_Mouse1.93305698
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.91180090
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.89499213
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.88150114
18PIAS1_25552417_ChIP-Seq_VCAP_Human1.87931465
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.87921092
20EST1_17652178_ChIP-ChIP_JURKAT_Human1.86011609
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.84961600
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.84384223
23HTT_18923047_ChIP-ChIP_STHdh_Human1.81792750
24RNF2_18974828_ChIP-Seq_MESCs_Mouse1.80171929
25EZH2_18974828_ChIP-Seq_MESCs_Mouse1.80171929
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.79532244
27TAF15_26573619_Chip-Seq_HEK293_Human1.78280515
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77405517
29NRF2_20460467_ChIP-Seq_MEFs_Mouse1.77002279
30NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.77002279
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.76523090
32WT1_19549856_ChIP-ChIP_CCG9911_Human1.76016238
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75628290
34JARID2_20064375_ChIP-Seq_MESCs_Mouse1.75510713
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.71672445
36OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.69415766
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.68186632
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.67335551
39* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.66842304
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.66824404
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.66794890
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64568084
43* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.62891327
44IGF1R_20145208_ChIP-Seq_DFB_Human1.62067519
45SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.61698493
46P300_19829295_ChIP-Seq_ESCs_Human1.61150127
47SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.59941649
48PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.56976514
49RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.55248853
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55083676
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54382353
52DROSHA_22980978_ChIP-Seq_HELA_Human1.52609457
53TP53_18474530_ChIP-ChIP_U2OS_Human1.50768327
54ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49819711
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.49768084
56EZH2_27294783_Chip-Seq_ESCs_Mouse1.48547406
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48111019
58AR_21909140_ChIP-Seq_LNCAP_Human1.48091658
59RNF2_27304074_Chip-Seq_ESCs_Mouse1.47711421
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.46623301
61VDR_22108803_ChIP-Seq_LS180_Human1.45674313
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45632008
63LXR_22158963_ChIP-Seq_LIVER_Mouse1.44185120
64SMAD4_21799915_ChIP-Seq_A2780_Human1.41272966
65* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41242892
66ER_23166858_ChIP-Seq_MCF-7_Human1.40400256
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39727000
68ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39325099
69* RXR_22158963_ChIP-Seq_LIVER_Mouse1.39263144
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38276252
71* STAT3_23295773_ChIP-Seq_U87_Human1.37385175
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36391804
73PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.35995335
74FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.35325200
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35104907
76EP300_21415370_ChIP-Seq_HL-1_Mouse1.35001830
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34351012
78CREB1_15753290_ChIP-ChIP_HEK293T_Human1.34020917
79NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.33863516
80RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33596637
81NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32969969
82SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32410850
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32192787
84FUS_26573619_Chip-Seq_HEK293_Human1.28105226
85MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26224135
86BCAT_22108803_ChIP-Seq_LS180_Human1.25777543
87PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25675179
88ZNF274_21170338_ChIP-Seq_K562_Hela1.25446691
89PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25061790
90SOX2_21211035_ChIP-Seq_LN229_Gbm1.24152546
91FOXM1_26456572_ChIP-Seq_MCF-7_Human1.23923995
92CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.21143497
93* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19799194
94FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18405236
95* SOX2_19829295_ChIP-Seq_ESCs_Human1.16739130
96HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16302157
97EZH2_27294783_Chip-Seq_NPCs_Mouse1.15500635
98JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.14806033
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14048795
100TCF4_22108803_ChIP-Seq_LS180_Human1.13943546
101NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13890609
102ETS1_20019798_ChIP-Seq_JURKAT_Human1.12828613
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12773936
104SRF_21415370_ChIP-Seq_HL-1_Mouse1.12386538
105HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11978756
106MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11553123
107REST_21632747_ChIP-Seq_MESCs_Mouse1.10404677
108RUNX2_22187159_ChIP-Seq_PCA_Human1.09510494
109* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.08921629
110CJUN_26792858_Chip-Seq_BT549_Human1.08718163
111SMAD4_21741376_ChIP-Seq_EPCs_Human1.07935931
112EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07607875
113EWS_26573619_Chip-Seq_HEK293_Human1.07208543
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06579910
115CDX2_22108803_ChIP-Seq_LS180_Human1.06262008
116NANOG_18555785_Chip-Seq_ESCs_Mouse1.05586941
117* TCF4_23295773_ChIP-Seq_U87_Human1.05344213
118CBP_20019798_ChIP-Seq_JUKART_Human1.04985408
119IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04985408
120KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04503333
121NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04167284
122* BRD4_25478319_ChIP-Seq_HGPS_Human1.04015750
123AR_25329375_ChIP-Seq_VCAP_Human1.03710247
124NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.03465835
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03280425
126WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02566859
127TP53_22573176_ChIP-Seq_HFKS_Human1.01147326
128HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00907705
129FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00743375
130CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.99833123
131P53_22387025_ChIP-Seq_ESCs_Mouse0.99183622
132ESR1_20079471_ChIP-ChIP_T-47D_Human0.98896512
133TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97126688
134* JUN_21703547_ChIP-Seq_K562_Human0.96926818
135TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96899073
136E2F1_18555785_Chip-Seq_ESCs_Mouse0.96703489
137SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96298444
138AHR_22903824_ChIP-Seq_MCF-7_Human0.96030016
139MYC_18940864_ChIP-ChIP_HL60_Human0.95765855
140CMYC_18555785_Chip-Seq_ESCs_Mouse0.95673531
141CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95596789
142CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.94514667
143EGR1_23403033_ChIP-Seq_LIVER_Mouse0.94471972
144AR_21572438_ChIP-Seq_LNCaP_Human0.94258447
145* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94212498
146KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94106100
147DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94096023
148STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93199345
149* NANOG_19829295_ChIP-Seq_ESCs_Human0.93041614
150DCP1A_22483619_ChIP-Seq_HELA_Human0.92716519

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.38302295
2MP0002254_reproductive_system_inflammat2.98389016
3MP0002139_abnormal_hepatobiliary_system2.75993336
4MP0005257_abnormal_intraocular_pressure2.56080774
5MP0003195_calcinosis2.47522197
6MP0003941_abnormal_skin_development2.33427393
7MP0000566_synostosis2.26794267
8MP0005365_abnormal_bile_salt2.23209009
9MP0008877_abnormal_DNA_methylation2.22504992
10MP0003718_maternal_effect2.17716739
11MP0003283_abnormal_digestive_organ2.16988226
12MP0010386_abnormal_urinary_bladder2.13970374
13MP0005503_abnormal_tendon_morphology1.98392793
14MP0005171_absent_coat_pigmentation1.96323996
15MP0009697_abnormal_copulation1.94067038
16MP0005085_abnormal_gallbladder_physiolo1.94006983
17MP0003950_abnormal_plasma_membrane1.93570744
18MP0005360_urolithiasis1.93318958
19MP0003880_abnormal_central_pattern1.92544395
20MP0010234_abnormal_vibrissa_follicle1.91549585
21MP0010678_abnormal_skin_adnexa1.86046490
22MP0009384_cardiac_valve_regurgitation1.84444764
23MP0000647_abnormal_sebaceous_gland1.81963576
24MP0002876_abnormal_thyroid_physiology1.80364671
25MP0003186_abnormal_redox_activity1.75722518
26MP0000427_abnormal_hair_cycle1.72281738
27MP0004133_heterotaxia1.70517218
28MP0003122_maternal_imprinting1.68769500
29MP0003252_abnormal_bile_duct1.67908225
30MP0002837_dystrophic_cardiac_calcinosis1.67598039
31MP0005058_abnormal_lysosome_morphology1.65033697
32MP0004859_abnormal_synaptic_plasticity1.64424189
33MP0000920_abnormal_myelination1.64205064
34MP0000383_abnormal_hair_follicle1.64168611
35MP0004233_abnormal_muscle_weight1.62010270
36MP0008058_abnormal_DNA_repair1.55515036
37MP0005083_abnormal_biliary_tract1.51011988
38MP0001188_hyperpigmentation1.50910395
39MP0002735_abnormal_chemical_nociception1.46329807
40MP0002909_abnormal_adrenal_gland1.46295678
41MP0003806_abnormal_nucleotide_metabolis1.44137625
42MP0001984_abnormal_olfaction1.42282768
43MP0003136_yellow_coat_color1.42177341
44MP0010030_abnormal_orbit_morphology1.41566964
45MP0004147_increased_porphyrin_level1.41089315
46MP0000778_abnormal_nervous_system1.40255764
47MP0003890_abnormal_embryonic-extraembry1.38322189
48MP0006072_abnormal_retinal_apoptosis1.36453658
49MP0003634_abnormal_glial_cell1.35800334
50MP0000372_irregular_coat_pigmentation1.34479176
51MP0002163_abnormal_gland_morphology1.32207011
52MP0002064_seizures1.29470344
53MP0000569_abnormal_digit_pigmentation1.28060459
54MP0002734_abnormal_mechanical_nocicepti1.27850603
55MP0003937_abnormal_limbs/digits/tail_de1.26745111
56MP0003868_abnormal_feces_composition1.25819383
57MP0004742_abnormal_vestibular_system1.25642961
58MP0004043_abnormal_pH_regulation1.24828471
59MP0000358_abnormal_cell_content/1.24215168
60MP0005187_abnormal_penis_morphology1.23317963
61MP0009840_abnormal_foam_cell1.22897081
62MP0005367_renal/urinary_system_phenotyp1.19523888
63MP0000516_abnormal_urinary_system1.19523888
64MP0003172_abnormal_lysosome_physiology1.19206043
65MP0000639_abnormal_adrenal_gland1.18612636
66MP0001958_emphysema1.18350047
67MP0001299_abnormal_eye_distance/1.17644690
68MP0008875_abnormal_xenobiotic_pharmacok1.16758042
69MP0004134_abnormal_chest_morphology1.13317627
70MP0000462_abnormal_digestive_system1.13255701
71MP0002233_abnormal_nose_morphology1.12400350
72MP0005379_endocrine/exocrine_gland_phen1.12026073
73MP0003690_abnormal_glial_cell1.11808225
74MP0005248_abnormal_Harderian_gland1.11350480
75MP0008057_abnormal_DNA_replication1.10976313
76MP0004019_abnormal_vitamin_homeostasis1.10841620
77MP0004270_analgesia1.10212272
78MP0002736_abnormal_nociception_after1.07833801
79MP0008775_abnormal_heart_ventricle1.07435244
80MP0002067_abnormal_sensory_capabilities1.06990786
81MP0002272_abnormal_nervous_system1.06680442
82MP0003635_abnormal_synaptic_transmissio1.06474199
83MP0001177_atelectasis1.06443206
84MP0009379_abnormal_foot_pigmentation1.04986137
85MP0009046_muscle_twitch1.04724377
86MP0003693_abnormal_embryo_hatching1.04417327
87MP0005395_other_phenotype1.04232757
88MP0002751_abnormal_autonomic_nervous1.03507341
89MP0004957_abnormal_blastocyst_morpholog1.03202615
90MP0002638_abnormal_pupillary_reflex1.02598908
91MP0005332_abnormal_amino_acid1.02071880
92MP0001440_abnormal_grooming_behavior1.01568212
93MP0001968_abnormal_touch/_nociception1.00619522
94MP0004215_abnormal_myocardial_fiber1.00585506
95MP0003755_abnormal_palate_morphology1.00457569
96MP0002295_abnormal_pulmonary_circulatio1.00369493
97MP0002184_abnormal_innervation0.99960047
98MP0003786_premature_aging0.99104357
99MP0000015_abnormal_ear_pigmentation0.98782879
100MP0002160_abnormal_reproductive_system0.98465279
101MP0002234_abnormal_pharynx_morphology0.97103752
102MP0002090_abnormal_vision0.97045307
103MP0001529_abnormal_vocalization0.97020130
104MP0009780_abnormal_chondrocyte_physiolo0.96009860
105MP0005551_abnormal_eye_electrophysiolog0.95500814
106MP0005408_hypopigmentation0.94465049
107MP0008932_abnormal_embryonic_tissue0.92558529
108MP0002210_abnormal_sex_determination0.92499369
109MP0005253_abnormal_eye_physiology0.92404368
110MP0005174_abnormal_tail_pigmentation0.91931752
111MP0001661_extended_life_span0.91676893
112MP0005646_abnormal_pituitary_gland0.90841684
113MP0009745_abnormal_behavioral_response0.90329880
114MP0006035_abnormal_mitochondrial_morpho0.90107807
115MP0000631_abnormal_neuroendocrine_gland0.89976930
116MP0004036_abnormal_muscle_relaxation0.87917978
117MP0003123_paternal_imprinting0.86525566
118MP0003119_abnormal_digestive_system0.86022010
119MP0005275_abnormal_skin_tensile0.85577836
120MP0003183_abnormal_peptide_metabolism0.85420730
121MP0004272_abnormal_basement_membrane0.85276186
122MP0004484_altered_response_of0.84376962
123MP0000749_muscle_degeneration0.82824858
124MP0002063_abnormal_learning/memory/cond0.82564277
125MP0005410_abnormal_fertilization0.82533548
126MP0000747_muscle_weakness0.82444383
127MP0002572_abnormal_emotion/affect_behav0.82218339
128MP0000955_abnormal_spinal_cord0.81434682
129MP0000653_abnormal_sex_gland0.81243655
130MP0006054_spinal_hemorrhage0.81016796
131MP0010329_abnormal_lipoprotein_level0.80847373
132MP0002084_abnormal_developmental_patter0.80840873
133MP0001929_abnormal_gametogenesis0.80653033
134MP0005508_abnormal_skeleton_morphology0.80551871
135MP0005409_darkened_coat_color0.80468438
136MP0001486_abnormal_startle_reflex0.80417629
137MP0008789_abnormal_olfactory_epithelium0.79947789
138MP0003632_abnormal_nervous_system0.78837249
139MP0004085_abnormal_heartbeat0.78122383
140MP0005389_reproductive_system_phenotype0.77687595
141MP0002882_abnormal_neuron_morphology0.77491152
142MP0003942_abnormal_urinary_system0.76946093
143MP0004145_abnormal_muscle_electrophysio0.76733998
144MP0001145_abnormal_male_reproductive0.75672356
145MP0001293_anophthalmia0.75294005
146MP0002229_neurodegeneration0.74328535
147MP0000681_abnormal_thyroid_gland0.74319314
148MP0001502_abnormal_circadian_rhythm0.74280969
149MP0002118_abnormal_lipid_homeostasis0.73989109
150MP0000013_abnormal_adipose_tissue0.73760959
151MP0002938_white_spotting0.72754507
152MP0002697_abnormal_eye_size0.72352288
153MP0002733_abnormal_thermal_nociception0.72345560
154MP0005595_abnormal_vascular_smooth0.72235707
155MP0005084_abnormal_gallbladder_morpholo0.72131167
156MP0000678_abnormal_parathyroid_gland0.72110710
157MP0003935_abnormal_craniofacial_develop0.71310067
158MP0010352_gastrointestinal_tract_polyps0.69749363
159MP0006036_abnormal_mitochondrial_physio0.69591872
160MP0003121_genomic_imprinting0.68639412
161MP0000538_abnormal_urinary_bladder0.67603448
162MP0002102_abnormal_ear_morphology0.65483181
163MP0005195_abnormal_posterior_eye0.65122796
164MP0001944_abnormal_pancreas_morphology0.64643076

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)3.56739198
2Systemic lupus erythematosus (HP:0002725)3.30587207
3Hypobetalipoproteinemia (HP:0003563)3.24533455
4Intrahepatic cholestasis (HP:0001406)3.23476652
5Neurofibrillary tangles (HP:0002185)3.11557047
6Hypoglycemic seizures (HP:0002173)2.99671546
7Focal motor seizures (HP:0011153)2.97189584
8Pancreatic cysts (HP:0001737)2.88025453
9Pancreatic fibrosis (HP:0100732)2.86933322
10Premature rupture of membranes (HP:0001788)2.80913435
11Hyperinsulinemic hypoglycemia (HP:0000825)2.80144358
12Conjugated hyperbilirubinemia (HP:0002908)2.79560214
13True hermaphroditism (HP:0010459)2.79374120
14Acute necrotizing encephalopathy (HP:0006965)2.77199928
15Arterial tortuosity (HP:0005116)2.61882331
16Progressive macrocephaly (HP:0004481)2.57859150
17Bell-shaped thorax (HP:0001591)2.57180299
18Medial flaring of the eyebrow (HP:0010747)2.56285985
19Acute encephalopathy (HP:0006846)2.55919181
20Increased CSF lactate (HP:0002490)2.54946161
21Deep venous thrombosis (HP:0002625)2.51022733
22Vascular tortuosity (HP:0004948)2.50198941
23Abnormality of midbrain morphology (HP:0002418)2.49033342
24Molar tooth sign on MRI (HP:0002419)2.49033342
25Increased hepatocellular lipid droplets (HP:0006565)2.46562421
26Skin nodule (HP:0200036)2.46082005
27Aplasia/Hypoplasia of the tongue (HP:0010295)2.45696006
28Akinesia (HP:0002304)2.44006320
29Vacuolated lymphocytes (HP:0001922)2.42153564
30Symptomatic seizures (HP:0011145)2.41796168
31Abnormal gallbladder physiology (HP:0012438)2.39777917
32Cholecystitis (HP:0001082)2.39777917
33Agitation (HP:0000713)2.38867222
34Methylmalonic acidemia (HP:0002912)2.36165640
35Complement deficiency (HP:0004431)2.32523055
36Hypoglycemic coma (HP:0001325)2.31778781
37Pancreatic islet-cell hyperplasia (HP:0004510)2.31548294
38Degeneration of the lateral corticospinal tracts (HP:0002314)2.30822629
39Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.30822629
40Intestinal atresia (HP:0011100)2.29854971
41Glomerulonephritis (HP:0000099)2.29035140
42Hypolipoproteinemia (HP:0010981)2.27999602
43Hyperglycemia (HP:0003074)2.25842276
44Mitochondrial inheritance (HP:0001427)2.25229442
45Cerebral inclusion bodies (HP:0100314)2.24922166
46Abnormal mitochondria in muscle tissue (HP:0008316)2.22114551
47Lipid accumulation in hepatocytes (HP:0006561)2.20888709
48Supernumerary spleens (HP:0009799)2.20414464
49Scanning speech (HP:0002168)2.19090944
50Coronal craniosynostosis (HP:0004440)2.18478279
51Glycosuria (HP:0003076)2.18351778
52Abnormality of urine glucose concentration (HP:0011016)2.18351778
53Congenital primary aphakia (HP:0007707)2.14493101
54Genital tract atresia (HP:0001827)2.14231646
55Turricephaly (HP:0000262)2.13792969
56Abnormality of methionine metabolism (HP:0010901)2.11308486
57Abnormality of the labia minora (HP:0012880)2.10546723
58Hypophosphatemic rickets (HP:0004912)2.10242040
59Xanthomatosis (HP:0000991)2.09439357
60Fat malabsorption (HP:0002630)2.09264830
61Prolonged partial thromboplastin time (HP:0003645)2.08660250
62Gait imbalance (HP:0002141)2.06909821
63Bifid tongue (HP:0010297)2.06295955
64Aplasia/Hypoplasia of the tibia (HP:0005772)2.06227984
65Short tibia (HP:0005736)2.05726131
66Thickened helices (HP:0000391)2.05453565
67Ketoacidosis (HP:0001993)2.05411636
68Vaginal atresia (HP:0000148)2.05206609
69Aplasia/hypoplasia of the uterus (HP:0008684)2.04057521
70Delayed gross motor development (HP:0002194)2.03721144
71Abnormality of aspartate family amino acid metabolism (HP:0010899)2.02975929
72Hypoplasia of the fovea (HP:0007750)2.02444112
73Aplasia/Hypoplasia of the fovea (HP:0008060)2.02444112
74Soft skin (HP:0000977)2.01403140
75Nephronophthisis (HP:0000090)2.00933724
76Occipital encephalocele (HP:0002085)1.99937624
77Abnormality of the renal cortex (HP:0011035)1.98411218
78Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.98233737
79Renal cortical cysts (HP:0000803)1.96072222
80Hepatic necrosis (HP:0002605)1.96071114
81Cerebral edema (HP:0002181)1.95303330
82Proximal tubulopathy (HP:0000114)1.94039964
83Popliteal pterygium (HP:0009756)1.92939310
84Volvulus (HP:0002580)1.92847989
85Epidermoid cyst (HP:0200040)1.90857238
86Hepatoblastoma (HP:0002884)1.90273746
87Congenital sensorineural hearing impairment (HP:0008527)1.89145854
88Methylmalonic aciduria (HP:0012120)1.88487991
89Large for gestational age (HP:0001520)1.88094686
90Infantile muscular hypotonia (HP:0008947)1.88074747
91Abnormality of vitamin B metabolism (HP:0004340)1.86463596
92Hepatocellular necrosis (HP:0001404)1.86264166
93Type II lissencephaly (HP:0007260)1.85815932
94Oculomotor apraxia (HP:0000657)1.84788225
95Pheochromocytoma (HP:0002666)1.83969385
96EEG with generalized epileptiform discharges (HP:0011198)1.83856133
97Abnormal lung lobation (HP:0002101)1.83838397
98Hyperlipoproteinemia (HP:0010980)1.83603947
99Steatorrhea (HP:0002570)1.83220266
100Abnormality of the pancreatic islet cells (HP:0006476)1.83179741
101Abnormality of endocrine pancreas physiology (HP:0012093)1.83179741
102Epileptiform EEG discharges (HP:0011182)1.82744721
103Abnormality of dentin (HP:0010299)1.82635817
104Hypokinesia (HP:0002375)1.81912831
105Supranuclear gaze palsy (HP:0000605)1.81384983
106Abnormality of the fovea (HP:0000493)1.81259375
107Myelomeningocele (HP:0002475)1.80445782
108Dysostosis multiplex (HP:0000943)1.80351347
109Abnormality of the renal medulla (HP:0100957)1.79615773
110Patchy hypopigmentation of hair (HP:0011365)1.79473049
111Aqueductal stenosis (HP:0002410)1.79254840
112Sensory axonal neuropathy (HP:0003390)1.79156397
113Nephrogenic diabetes insipidus (HP:0009806)1.78700934
114Male pseudohermaphroditism (HP:0000037)1.78469453
115Preaxial hand polydactyly (HP:0001177)1.76248894
116Sclerocornea (HP:0000647)1.74352372
117Central scotoma (HP:0000603)1.74103719
118Exercise-induced myalgia (HP:0003738)1.73064603
119Exotropia (HP:0000577)1.72879825
120Abnormality of glycolysis (HP:0004366)1.72677018
121Double outlet right ventricle (HP:0001719)1.72496678
122Congenital malformation of the right heart (HP:0011723)1.72496678
123Spastic gait (HP:0002064)1.71145345
124Drooling (HP:0002307)1.70539393
125Excessive salivation (HP:0003781)1.70539393
126Opisthotonus (HP:0002179)1.69982041
127Generalized tonic-clonic seizures (HP:0002069)1.68642812
128Abnormality of polysaccharide metabolism (HP:0011012)1.68251970
129Abnormality of glycosaminoglycan metabolism (HP:0004371)1.68251970
130Abnormality of mucopolysaccharide metabolism (HP:0011020)1.68251970
131Ketosis (HP:0001946)1.68140777
132Retinal dysplasia (HP:0007973)1.68089097
133Blue sclerae (HP:0000592)1.67808189
134Abnormality of monocarboxylic acid metabolism (HP:0010996)1.67504915
135Protuberant abdomen (HP:0001538)1.67052085
136Hypoplasia of the uterus (HP:0000013)1.66889000
137Hypomagnesemia (HP:0002917)1.64840752
138Severe muscular hypotonia (HP:0006829)1.64713751
139Postaxial hand polydactyly (HP:0001162)1.64578372
140Hypsarrhythmia (HP:0002521)1.63931278
141Axonal loss (HP:0003447)1.62492736
142Bile duct proliferation (HP:0001408)1.62468711
143Abnormal biliary tract physiology (HP:0012439)1.62468711
144Hypothermia (HP:0002045)1.62282108
145Median cleft lip (HP:0000161)1.61241928
146Hyperventilation (HP:0002883)1.60857490
147Hyperglycinuria (HP:0003108)1.60436816
148Neoplasm of the adrenal cortex (HP:0100641)1.60387494
149Anencephaly (HP:0002323)1.60247125
150Respiratory failure (HP:0002878)1.59355775
151Autoamputation (HP:0001218)1.59328810
152Hypoalphalipoproteinemia (HP:0003233)1.59276571
153Poor suck (HP:0002033)1.59165101
154Ankle clonus (HP:0011448)1.59085230
155Cystic liver disease (HP:0006706)1.58647336
156Osteomalacia (HP:0002749)1.58321282
157Disproportionate short-trunk short stature (HP:0003521)1.58135164
158Hyperglycinemia (HP:0002154)1.58043724
159Mesomelia (HP:0003027)1.57636344
160Dialeptic seizures (HP:0011146)1.56978168
161Anophthalmia (HP:0000528)1.56813556
162Abnormality of renal resorption (HP:0011038)1.56108968
163Lethargy (HP:0001254)1.55531642
164Oligodactyly (hands) (HP:0001180)1.54849704
165Postaxial foot polydactyly (HP:0001830)1.53052753
166Abnormality of serine family amino acid metabolism (HP:0010894)1.52925899
167Abnormality of glycine metabolism (HP:0010895)1.52925899
168Abnormal gallbladder morphology (HP:0012437)1.52781428
169Abnormality of complement system (HP:0005339)1.52220142
170Enlarged kidneys (HP:0000105)1.52209333
171Retinal atrophy (HP:0001105)1.52192679
172Aplasia/Hypoplasia of the lens (HP:0008063)1.50467651
173Diminished movement (HP:0002374)1.50017945
174Mucopolysacchariduria (HP:0008155)1.49410353
175Urinary glycosaminoglycan excretion (HP:0003541)1.49410353
176Abnormality of the intrinsic pathway (HP:0010989)1.49166292
177Abnormality of the corticospinal tract (HP:0002492)1.48211935
178Abnormality of the gallbladder (HP:0005264)1.47776342
179Lower limb hyperreflexia (HP:0002395)1.47536735
180Neuroendocrine neoplasm (HP:0100634)1.47164328
181Adrenal hypoplasia (HP:0000835)1.44950110
182Aplasia of the musculature (HP:0100854)1.44934727
183Renal Fanconi syndrome (HP:0001994)1.42539680
184Disproportionate tall stature (HP:0001519)1.42073761
185Pathologic fracture (HP:0002756)1.42065978

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.80790170
2EPHA43.41551432
3TRIM283.34370085
4PBK2.94628107
5ACVR1B2.78847704
6MST42.76612951
7TNIK2.70706884
8EPHA32.48510100
9INSRR2.36306477
10CAMKK22.24870311
11PAK32.22190298
12MAP2K72.15809654
13MAP3K42.13652432
14MET2.09274894
15BCR2.07421028
16AKT32.07337496
17STK392.04568476
18NTRK31.99027210
19PDK21.97889778
20OXSR11.84768317
21MAP3K121.84518702
22DDR21.80767163
23STK241.78650806
24MUSK1.70909637
25LIMK11.69661769
26ERBB31.69646326
27STK31.69326604
28MKNK21.68903341
29EIF2AK31.67071654
30NEK11.66002886
31PLK21.65611788
32FER1.64268132
33BMPR1B1.61337354
34PLK31.60506879
35MAPK151.59535520
36MAP2K41.53628006
37GRK11.52034434
38PIK3CA1.49823568
39VRK21.49035768
40PNCK1.48692234
41BUB11.45820670
42ICK1.42228532
43CASK1.40054358
44CAMK2D1.36092909
45CAMK2B1.35995499
46SIK31.31283183
47SGK2231.28461158
48SGK4941.28461158
49ERBB41.24568855
50PIK3CG1.17430474
51EIF2AK11.16015574
52PAK61.15533116
53NEK61.14642481
54WNK41.12734164
55KSR11.12117179
56BRSK21.12087392
57PDGFRA1.11176815
58ZAK1.10466681
59PHKG11.09407818
60PHKG21.09407818
61CAMKK11.07472981
62MAP3K61.07009028
63OBSCN1.06234667
64MKNK11.05641483
65TTK1.03092344
66TAOK21.02679302
67PRPF4B1.02659133
68LATS11.01612217
69FGR0.98907390
70PLK10.98674851
71FRK0.98652244
72WNK30.98524350
73CAMK2G0.97017110
74UHMK10.96256793
75NUAK10.96116825
76YES10.95671809
77CAMK1G0.94720780
78CAMK2A0.94239904
79CSNK1G10.92651414
80PRKD30.92249864
81NTRK10.91723575
82PKN10.91444413
83PINK10.91430747
84PRKCE0.90605913
85PLK40.89546010
86BRAF0.89202950
87MARK10.89146256
88CSNK1A1L0.87981222
89TGFBR10.81430063
90WEE10.81382890
91DAPK20.80979493
92CAMK1D0.79320256
93PRKCI0.79118905
94VRK10.76598727
95PTK20.74528243
96EPHB10.74483747
97IRAK20.74069783
98CSNK1G30.72953268
99GRK70.71900917
100CDK50.68782866
101TTN0.67415742
102FGFR10.67273242
103ROCK20.66027926
104BCKDK0.65619836
105SGK20.65345875
106MINK10.64525078
107STK38L0.64086770
108CDK80.63983404
109STK160.63112092
110CDK140.61670699
111PTK2B0.61266491
112CSNK1G20.60917283
113BRSK10.60246523
114ADRBK20.59999575
115MAPK130.59270800
116PTK60.58463859
117TAF10.57784387
118CDK180.56630182
119PRKCG0.56486524
120LMTK20.56032037
121MAPK70.55342846
122CDK150.55138268
123CDC42BPA0.54931833
124MYLK0.52582140
125STK40.51919586
126MAP2K10.51629294
127DYRK20.50988578
128SRPK10.50792549
129TESK10.50687830
130PRKD10.49930604
131PAK40.49853519
132CDK190.49767930
133MST1R0.48520863
134WNK10.48514297
135TAOK30.47323053
136RET0.47176157
137PDGFRB0.46841741
138ABL20.46651485
139EPHB20.46544366
140EIF2AK20.45845352
141MAP3K90.44687732
142PRKG10.44634574
143DYRK1A0.44425667
144FGFR20.43774873
145MELK0.43471081
146BMPR20.41429314
147EPHA20.39879036
148MAP3K20.38374424
149ILK0.36354874
150CSNK1A10.36181627
151ROCK10.34330655
152ATM0.31695134
153FLT30.30669190

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007502.53187601
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.35740398
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.25088362
4Vibrio cholerae infection_Homo sapiens_hsa051102.22493593
5Steroid biosynthesis_Homo sapiens_hsa001002.19383632
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.14428652
7Sulfur metabolism_Homo sapiens_hsa009202.14202113
8Nitrogen metabolism_Homo sapiens_hsa009102.13065124
9Basal transcription factors_Homo sapiens_hsa030222.12731630
10Protein export_Homo sapiens_hsa030602.04017351
11Proteasome_Homo sapiens_hsa030502.02216516
12Collecting duct acid secretion_Homo sapiens_hsa049662.00046408
13Fatty acid elongation_Homo sapiens_hsa000621.84210569
14Complement and coagulation cascades_Homo sapiens_hsa046101.80820599
15Primary bile acid biosynthesis_Homo sapiens_hsa001201.71343916
16Butanoate metabolism_Homo sapiens_hsa006501.69725868
17Folate biosynthesis_Homo sapiens_hsa007901.68248902
18Non-homologous end-joining_Homo sapiens_hsa034501.64395784
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.64287180
20Synaptic vesicle cycle_Homo sapiens_hsa047211.64116381
21RNA polymerase_Homo sapiens_hsa030201.58055681
22Homologous recombination_Homo sapiens_hsa034401.56576877
23Histidine metabolism_Homo sapiens_hsa003401.53338093
24Parkinsons disease_Homo sapiens_hsa050121.50559442
25Mismatch repair_Homo sapiens_hsa034301.48857580
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.46138374
27Lysosome_Homo sapiens_hsa041421.45479163
28Nucleotide excision repair_Homo sapiens_hsa034201.44019577
29Selenocompound metabolism_Homo sapiens_hsa004501.41288621
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.39419268
31GABAergic synapse_Homo sapiens_hsa047271.37486433
32Glutathione metabolism_Homo sapiens_hsa004801.35857597
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.35556480
34Tryptophan metabolism_Homo sapiens_hsa003801.33846567
35Arginine and proline metabolism_Homo sapiens_hsa003301.29062870
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.28336942
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.26503712
38Insulin secretion_Homo sapiens_hsa049111.26204972
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.24886165
40Nicotine addiction_Homo sapiens_hsa050331.24731732
41Huntingtons disease_Homo sapiens_hsa050161.21626932
42Phagosome_Homo sapiens_hsa041451.21332885
43Arginine biosynthesis_Homo sapiens_hsa002201.17442145
44Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.16314299
45Oxidative phosphorylation_Homo sapiens_hsa001901.15944309
46Propanoate metabolism_Homo sapiens_hsa006401.15327040
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.12997840
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.12798666
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.11736697
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.11040793
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.08041948
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07464958
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.05673475
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04353511
55Phenylalanine metabolism_Homo sapiens_hsa003601.04277165
56Peroxisome_Homo sapiens_hsa041461.03891545
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03596687
58Axon guidance_Homo sapiens_hsa043601.03239977
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02010801
60RNA degradation_Homo sapiens_hsa030181.00977368
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99635436
62Prion diseases_Homo sapiens_hsa050200.99132845
63Tyrosine metabolism_Homo sapiens_hsa003500.99002188
64Regulation of autophagy_Homo sapiens_hsa041400.97943948
65Glycosaminoglycan degradation_Homo sapiens_hsa005310.97134463
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96461770
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95666308
68Fanconi anemia pathway_Homo sapiens_hsa034600.95173064
69Fatty acid degradation_Homo sapiens_hsa000710.94777619
70Serotonergic synapse_Homo sapiens_hsa047260.94641475
71Hippo signaling pathway_Homo sapiens_hsa043900.91676947
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.91057122
73Morphine addiction_Homo sapiens_hsa050320.90451148
74Fatty acid metabolism_Homo sapiens_hsa012120.89237976
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88541765
76Cocaine addiction_Homo sapiens_hsa050300.88267062
77Glutamatergic synapse_Homo sapiens_hsa047240.87952062
78Taste transduction_Homo sapiens_hsa047420.87823551
79Phototransduction_Homo sapiens_hsa047440.86819922
80Oocyte meiosis_Homo sapiens_hsa041140.86471244
81Staphylococcus aureus infection_Homo sapiens_hsa051500.86432968
82Ether lipid metabolism_Homo sapiens_hsa005650.85370937
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83755194
84Circadian rhythm_Homo sapiens_hsa047100.82028291
85One carbon pool by folate_Homo sapiens_hsa006700.81610509
86RNA transport_Homo sapiens_hsa030130.81552991
87Dilated cardiomyopathy_Homo sapiens_hsa054140.80956276
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.80791687
89Metabolic pathways_Homo sapiens_hsa011000.80466168
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80157424
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79897802
92Long-term depression_Homo sapiens_hsa047300.79640987
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79620886
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77529627
95TGF-beta signaling pathway_Homo sapiens_hsa043500.77319224
96Caffeine metabolism_Homo sapiens_hsa002320.76899613
97Pyrimidine metabolism_Homo sapiens_hsa002400.76407086
98Sphingolipid metabolism_Homo sapiens_hsa006000.75247860
99Circadian entrainment_Homo sapiens_hsa047130.75111943
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74925553
101Amphetamine addiction_Homo sapiens_hsa050310.72917863
102Dopaminergic synapse_Homo sapiens_hsa047280.72712429
103Purine metabolism_Homo sapiens_hsa002300.71564318
104ECM-receptor interaction_Homo sapiens_hsa045120.70687429
105Bile secretion_Homo sapiens_hsa049760.70369507
106Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68115878
107Pyruvate metabolism_Homo sapiens_hsa006200.67708538
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67684793
109Alzheimers disease_Homo sapiens_hsa050100.66932481
110Basal cell carcinoma_Homo sapiens_hsa052170.66467148
111ABC transporters_Homo sapiens_hsa020100.63207043
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63158538
113DNA replication_Homo sapiens_hsa030300.63053985
114beta-Alanine metabolism_Homo sapiens_hsa004100.62948323
115Chemical carcinogenesis_Homo sapiens_hsa052040.62582261
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61629746
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61408717
118Type II diabetes mellitus_Homo sapiens_hsa049300.60528471
119Carbon metabolism_Homo sapiens_hsa012000.60102535
120Cardiac muscle contraction_Homo sapiens_hsa042600.58382264
121Cholinergic synapse_Homo sapiens_hsa047250.58008609
122Base excision repair_Homo sapiens_hsa034100.57759224
123Gap junction_Homo sapiens_hsa045400.57375869
124Cell cycle_Homo sapiens_hsa041100.56292396
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56077487
126Thyroid hormone synthesis_Homo sapiens_hsa049180.53907762
127Wnt signaling pathway_Homo sapiens_hsa043100.51578331
128Retinol metabolism_Homo sapiens_hsa008300.51440158
129p53 signaling pathway_Homo sapiens_hsa041150.51436858
130Starch and sucrose metabolism_Homo sapiens_hsa005000.51190766
131ErbB signaling pathway_Homo sapiens_hsa040120.50568234
132Drug metabolism - other enzymes_Homo sapiens_hsa009830.50239100
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.49830441
134Mineral absorption_Homo sapiens_hsa049780.48871590
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47530618
136Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46366238
1372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46335272
138Rheumatoid arthritis_Homo sapiens_hsa053230.45198473
139GnRH signaling pathway_Homo sapiens_hsa049120.44222117
140Other glycan degradation_Homo sapiens_hsa005110.42040713
141Focal adhesion_Homo sapiens_hsa045100.42020622
142Fat digestion and absorption_Homo sapiens_hsa049750.42018454
143Amoebiasis_Homo sapiens_hsa051460.41761178
144Tight junction_Homo sapiens_hsa045300.41455371
145PPAR signaling pathway_Homo sapiens_hsa033200.41137096
146Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40759270
147Long-term potentiation_Homo sapiens_hsa047200.39342130
148Renal cell carcinoma_Homo sapiens_hsa052110.39341233
149Renin secretion_Homo sapiens_hsa049240.38676104
150alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37788787
151Hedgehog signaling pathway_Homo sapiens_hsa043400.37060169

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