SNX25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cornea development in camera-type eye (GO:0061303)5.78347876
2gland morphogenesis (GO:0022612)5.47921921
3embryonic camera-type eye morphogenesis (GO:0048596)5.47046150
4locomotory exploration behavior (GO:0035641)5.24306293
5nuclear pore complex assembly (GO:0051292)5.23976385
6dorsal/ventral axis specification (GO:0009950)5.18151815
7regulation of short-term neuronal synaptic plasticity (GO:0048172)4.90255132
8vocalization behavior (GO:0071625)4.62660999
9positive regulation of DNA-templated transcription, initiation (GO:2000144)4.61924428
10surfactant homeostasis (GO:0043129)4.59939424
11astrocyte differentiation (GO:0048708)4.45960944
12nuclear pore organization (GO:0006999)4.36407358
13chemical homeostasis within a tissue (GO:0048875)4.23880128
14regulation of RNA export from nucleus (GO:0046831)4.17549658
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.13364402
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.11565244
17synaptic vesicle maturation (GO:0016188)4.07917985
18embryonic eye morphogenesis (GO:0048048)4.05994596
19layer formation in cerebral cortex (GO:0021819)4.02273923
20pre-miRNA processing (GO:0031054)4.00913973
21regulation of timing of cell differentiation (GO:0048505)3.94137634
22embryonic foregut morphogenesis (GO:0048617)3.93343691
23regulation of synaptic vesicle exocytosis (GO:2000300)3.92630265
24positive regulation of neuroblast proliferation (GO:0002052)3.92157489
25synaptic vesicle exocytosis (GO:0016079)3.90037888
26regulation of cell fate specification (GO:0042659)3.88917484
27mitotic sister chromatid cohesion (GO:0007064)3.81427480
28cellular potassium ion homeostasis (GO:0030007)3.79667647
29regulation of anoikis (GO:2000209)3.79394063
30sodium ion export (GO:0071436)3.75488985
31exploration behavior (GO:0035640)3.68494968
32artery development (GO:0060840)3.64827952
33activation of protein kinase A activity (GO:0034199)3.61904747
34glandular epithelial cell development (GO:0002068)3.57132330
35regulation of glutamate receptor signaling pathway (GO:1900449)3.52137015
36mitotic chromosome condensation (GO:0007076)3.50579342
37prepulse inhibition (GO:0060134)3.48915209
38negative regulation of anoikis (GO:2000811)3.44837179
39neurotransmitter secretion (GO:0007269)3.44762470
40CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.44595818
41regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.43658474
42regulation of nucleobase-containing compound transport (GO:0032239)3.42765216
43hindbrain development (GO:0030902)3.42185984
44gastrulation with mouth forming second (GO:0001702)3.40838239
45pore complex assembly (GO:0046931)3.40098195
46columnar/cuboidal epithelial cell development (GO:0002066)3.36390420
47proline transport (GO:0015824)3.36118550
48glutamate secretion (GO:0014047)3.35851001
49regulation of development, heterochronic (GO:0040034)3.32557210
50regulation of synaptic vesicle transport (GO:1902803)3.31588695
51regulation of synapse structural plasticity (GO:0051823)3.28953787
52regulation of long-term neuronal synaptic plasticity (GO:0048169)3.25762726
53regulation of NFAT protein import into nucleus (GO:0051532)3.25193398
54mating behavior (GO:0007617)3.22334440
55positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.20987396
56regulation of ARF protein signal transduction (GO:0032012)3.20750090
57synaptic vesicle docking involved in exocytosis (GO:0016081)3.20634926
58negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.18241632
59positive regulation of cell fate commitment (GO:0010455)3.14968788
60protein localization to synapse (GO:0035418)3.14655268
61neuron cell-cell adhesion (GO:0007158)3.13910153
62oocyte development (GO:0048599)3.13686490
63regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.10113912
64peptidyl-lysine methylation (GO:0018022)3.09763809
65protein localization to chromosome, centromeric region (GO:0071459)3.09190912
66ionotropic glutamate receptor signaling pathway (GO:0035235)3.06861334
67regulation of histone H3-K27 methylation (GO:0061085)3.06819609
68protein localization to endosome (GO:0036010)3.04446910
69cellular response to reactive nitrogen species (GO:1902170)3.03492664
70cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.02425503
71G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.02166047
72regulation of neuronal synaptic plasticity (GO:0048168)3.01558753
73regulation of neuroblast proliferation (GO:1902692)3.00427514
74response to histamine (GO:0034776)2.98280326
75vesicle transport along microtubule (GO:0047496)2.97609699
76peptidyl-lysine trimethylation (GO:0018023)2.95236503
77regulation of dendritic spine morphogenesis (GO:0061001)2.94668317
78T cell lineage commitment (GO:0002360)2.92893775
79mitotic sister chromatid segregation (GO:0000070)2.92290428
80lymphangiogenesis (GO:0001946)2.92105954
81negative regulation of dendrite morphogenesis (GO:0050774)2.91357408
82dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.90896719
83COPII vesicle coating (GO:0048208)2.90520122
84regulation of excitatory postsynaptic membrane potential (GO:0060079)2.90225341
85neurotransmitter-gated ion channel clustering (GO:0072578)2.89292430
86potassium ion import (GO:0010107)2.88906184
87negative regulation of histone methylation (GO:0031061)2.87984441
88membrane repolarization (GO:0086009)2.87931342
89regulation of DNA-templated transcription, initiation (GO:2000142)2.87807001
90regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.86563618
91protein localization to microtubule (GO:0035372)2.85046438
92sister chromatid segregation (GO:0000819)2.85018447
93positive regulation of catenin import into nucleus (GO:0035413)2.84703021
94cellular sodium ion homeostasis (GO:0006883)2.83592385
95dendritic spine morphogenesis (GO:0060997)2.83281352
96negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.80452174
97innervation (GO:0060384)2.80359548
98positive regulation of synapse maturation (GO:0090129)2.79731648
99membrane repolarization during action potential (GO:0086011)2.78981612
100negative regulation of DNA repair (GO:0045738)2.78928815
101regulation of sister chromatid cohesion (GO:0007063)2.78611692
102regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.77615560
103long-term synaptic potentiation (GO:0060291)2.77047361
104neuromuscular process controlling balance (GO:0050885)2.76248273
105clathrin coat assembly (GO:0048268)2.76015276
106glutamate receptor signaling pathway (GO:0007215)2.75899701
107regulation of postsynaptic membrane potential (GO:0060078)2.75557243
108regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.74753726
109regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.74753726
110histone H3-K9 methylation (GO:0051567)2.74510117
111neurotransmitter transport (GO:0006836)2.74027999
112interkinetic nuclear migration (GO:0022027)2.73678396
113adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.73538548
114cellular response to virus (GO:0098586)2.73102906
115signal transduction involved in regulation of gene expression (GO:0023019)2.72928332
116regulation of histone H3-K9 methylation (GO:0051570)2.72828340
117behavioral response to cocaine (GO:0048148)2.72777088
118striatum development (GO:0021756)2.72463418
119cytoskeletal anchoring at plasma membrane (GO:0007016)2.71472863
120dopamine receptor signaling pathway (GO:0007212)2.71406448
121gamma-aminobutyric acid transport (GO:0015812)2.71329411
122mannose metabolic process (GO:0006013)2.70695873
123negative regulation of sodium ion transport (GO:0010766)2.70068724
124regulation of clathrin-mediated endocytosis (GO:2000369)2.69698595
125dendrite morphogenesis (GO:0048813)2.67918038
126neuron-neuron synaptic transmission (GO:0007270)2.66489028
127membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.66337849
128pericardium development (GO:0060039)2.65731286
129nerve growth factor signaling pathway (GO:0038180)2.65217589
130positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.64098220
131cAMP biosynthetic process (GO:0006171)2.64097963
132protein targeting to Golgi (GO:0000042)2.62781765
133positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.62564490
134positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.62564490
135positive regulation of mitotic sister chromatid separation (GO:1901970)2.62564490
136long-term memory (GO:0007616)2.61752979
137peptidyl-lysine dimethylation (GO:0018027)2.61472331
138cell communication by electrical coupling (GO:0010644)2.61440360
139mammary gland epithelial cell proliferation (GO:0033598)2.61017446
140regulation of synaptic transmission, glutamatergic (GO:0051966)2.60631948
141neuron recognition (GO:0008038)2.60182103
142positive regulation of membrane potential (GO:0045838)2.57908521
143protein retention in ER lumen (GO:0006621)2.56316442
144eye morphogenesis (GO:0048592)2.55813169
145positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.55690045
146establishment of protein localization to Golgi (GO:0072600)2.54385205
147positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.54328926
148maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.53918178
149ERK1 and ERK2 cascade (GO:0070371)2.52134845
150synaptic transmission, glutamatergic (GO:0035249)2.51969054
151regulation of synaptic plasticity (GO:0048167)2.51782386
152cerebellar Purkinje cell differentiation (GO:0021702)2.51050426
153regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.50989377
154intestinal epithelial cell development (GO:0060576)2.50402610
155peptidyl-threonine phosphorylation (GO:0018107)2.50165222
156establishment of spindle orientation (GO:0051294)2.49950680
157synaptic transmission, dopaminergic (GO:0001963)2.49220507
158cellular response to nitric oxide (GO:0071732)2.48385264
159membrane depolarization during action potential (GO:0086010)2.48235599
160regulation of protein kinase A signaling (GO:0010738)2.47054325
161regulation of neurotransmitter levels (GO:0001505)2.46879746
162paraxial mesoderm development (GO:0048339)2.46782617
163behavioral response to ethanol (GO:0048149)2.46345191
164B cell receptor signaling pathway (GO:0050853)2.45729120
165establishment of nucleus localization (GO:0040023)2.45549787
166gamma-aminobutyric acid signaling pathway (GO:0007214)2.45295943
167membrane disassembly (GO:0030397)2.45295023
168nuclear envelope disassembly (GO:0051081)2.45295023
169mitotic nuclear envelope disassembly (GO:0007077)2.44886110
170regulation of neurotransmitter uptake (GO:0051580)2.44346234
171intraspecies interaction between organisms (GO:0051703)2.44064440
172social behavior (GO:0035176)2.44064440
173notochord development (GO:0030903)2.43839075
174synaptic vesicle endocytosis (GO:0048488)2.43714081
175peptidyl-threonine modification (GO:0018210)2.43138065
176NLS-bearing protein import into nucleus (GO:0006607)2.43090045
177regulation of hippo signaling (GO:0035330)2.42948879
178synapse assembly (GO:0007416)2.38885586
179synapsis (GO:0007129)2.38549934
180focal adhesion assembly (GO:0048041)2.37806015
181cell-substrate adherens junction assembly (GO:0007045)2.37806015
182membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.37057386
183negative regulation of osteoblast proliferation (GO:0033689)2.36865739
184retrograde transport, vesicle recycling within Golgi (GO:0000301)2.36185415
185regulation of Rap GTPase activity (GO:0032317)2.36163537
186transmission of nerve impulse (GO:0019226)2.36120808
187membrane depolarization (GO:0051899)2.35762172
188histone H2A monoubiquitination (GO:0035518)2.34603256
189cell adhesion mediated by integrin (GO:0033627)2.33474318
190nucleus localization (GO:0051647)2.33472567
191histone H3-K9 demethylation (GO:0033169)2.32678106
192adherens junction assembly (GO:0034333)2.31364601
193regulation of steroid hormone biosynthetic process (GO:0090030)2.30874942
194microtubule anchoring (GO:0034453)2.30669145
195establishment of spindle localization (GO:0051293)2.29595462
196regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.29376957
197glandular epithelial cell differentiation (GO:0002067)2.29196618

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.55566394
2EZH2_22144423_ChIP-Seq_EOC_Human4.15020964
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.73635527
4HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse3.38476901
5AR_21909140_ChIP-Seq_LNCAP_Human3.38015114
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.20213358
7KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.49140937
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.45937046
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.43773297
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.38607745
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.32263389
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.29279672
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.28811103
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.26182694
15DROSHA_22980978_ChIP-Seq_HELA_Human2.25759634
16GBX2_23144817_ChIP-Seq_PC3_Human2.24703746
17SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.24237536
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.16828452
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.14316454
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.13967029
21WT1_19549856_ChIP-ChIP_CCG9911_Human2.04534191
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.02478341
23JARID2_20064375_ChIP-Seq_MESCs_Mouse2.00852868
24RNF2_18974828_ChIP-Seq_MESCs_Mouse1.98279692
25EZH2_18974828_ChIP-Seq_MESCs_Mouse1.98279692
26REST_21632747_ChIP-Seq_MESCs_Mouse1.92430033
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.91840432
28MYC_22102868_ChIP-Seq_BL_Human1.86757371
29JARID2_20075857_ChIP-Seq_MESCs_Mouse1.86553942
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.83525967
31E2F1_21310950_ChIP-Seq_MCF-7_Human1.79520970
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75657650
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.70955914
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69641478
35CLOCK_20551151_ChIP-Seq_293T_Human1.68714860
36PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.68641447
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.68506935
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.64576063
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.64372112
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.61565638
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.60755111
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.60411896
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.54437301
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.53931813
45SMAD4_21799915_ChIP-Seq_A2780_Human1.52327316
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52173020
47ZNF274_21170338_ChIP-Seq_K562_Hela1.48938345
48BRD4_25478319_ChIP-Seq_HGPS_Human1.47942152
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.47322089
50SALL4_18804426_ChIP-ChIP_XEN_Mouse1.46777184
51SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.44492818
52REST_18959480_ChIP-ChIP_MESCs_Mouse1.43555178
53NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.41032655
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.37707774
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36831335
56SOX9_24532713_ChIP-Seq_HFSC_Mouse1.36714793
57BCAT_22108803_ChIP-Seq_LS180_Human1.36204943
58TCF4_18268006_ChIP-ChIP_LS174T_Human1.35865095
59* AHR_22903824_ChIP-Seq_MCF-7_Human1.35228600
60* SOX2_21211035_ChIP-Seq_LN229_Gbm1.34629846
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34415826
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.34148049
63* ARNT_22903824_ChIP-Seq_MCF-7_Human1.33902378
64KDM2B_26808549_Chip-Seq_K562_Human1.32745305
65SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.31967005
66EED_16625203_ChIP-ChIP_MESCs_Mouse1.31660518
67EZH2_27304074_Chip-Seq_ESCs_Mouse1.31375162
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28460453
69PPAR_26484153_Chip-Seq_NCI-H1993_Human1.28124948
70TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.27481931
71HIF1A_21447827_ChIP-Seq_MCF-7_Human1.26756992
72* FOXO3_23340844_ChIP-Seq_DLD1_Human1.26659949
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26614592
74AR_21572438_ChIP-Seq_LNCaP_Human1.25913214
75FOXM1_26456572_ChIP-Seq_MCF-7_Human1.25116242
76FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.23783362
77SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.23757554
78SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.23757554
79ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.23587047
80WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23363078
81TAF15_26573619_Chip-Seq_HEK293_Human1.22754805
82NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.22736771
83CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.22688769
84AR_19668381_ChIP-Seq_PC3_Human1.22021781
85PIAS1_25552417_ChIP-Seq_VCAP_Human1.20666492
86TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20458252
87STAT3_23295773_ChIP-Seq_U87_Human1.20349511
88BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17851504
89* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16971363
90FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.16871670
91NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.15496505
92CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15454023
93MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.15418094
94* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14827180
95KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13086832
96AR_25329375_ChIP-Seq_VCAP_Human1.12410067
97GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12361796
98SALL1_21062744_ChIP-ChIP_HESCs_Human1.11710081
99TP53_16413492_ChIP-PET_HCT116_Human1.10075955
100WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09498385
101TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08639900
102NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.08309937
103UBF1/2_26484160_Chip-Seq_HMECs_Human1.08244263
104ESR1_20079471_ChIP-ChIP_T-47D_Human1.07909247
105TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07665335
106KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07224828
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07217317
108CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.06286521
109OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06144124
110STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.06095096
111CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05730301
112FLI1_27457419_Chip-Seq_LIVER_Mouse1.05325510
113DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.05157592
114TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.05063901
115SMAD3_21741376_ChIP-Seq_EPCs_Human1.04543982
116EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.04523435
117TRIM28_21343339_ChIP-Seq_HEK293_Human1.03233139
118GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02376274
119CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02156391
120SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01839450
121RING1B_27294783_Chip-Seq_ESCs_Mouse1.00956787
122* TCF4_23295773_ChIP-Seq_U87_Human1.00088674
123ERG_21242973_ChIP-ChIP_JURKAT_Human1.00027042
124NOTCH1_21737748_ChIP-Seq_TLL_Human0.99683308
125* P300_19829295_ChIP-Seq_ESCs_Human0.99428787
126SOX9_26525672_Chip-Seq_HEART_Mouse0.98259827
127PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97154396
128TP63_23658742_ChIP-Seq_EP156T_Human0.96893003
129NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96714365
130SMAD3_21741376_ChIP-Seq_ESCs_Human0.96658647
131* FOXA2_19822575_ChIP-Seq_HepG2_Human0.95524441
132SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94628348
133TP53_18474530_ChIP-ChIP_U2OS_Human0.94556226
134CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93968770
135ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93362442
136SMAD4_21741376_ChIP-Seq_HESCs_Human0.93219660
137YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93194575
138DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92666388
139GATA1_22025678_ChIP-Seq_K562_Human0.91738422
140MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91710748
141POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91343356
142EP300_21415370_ChIP-Seq_HL-1_Mouse0.91310743
143SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91221979
144* RUNX2_22187159_ChIP-Seq_PCA_Human0.90173195
145CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90091766
146ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.89371421
147SMAD3_21741376_ChIP-Seq_HESCs_Human0.89134061
148RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.88520183
149GF1B_26923725_Chip-Seq_HPCs_Mouse0.88128529
150TBX3_20139965_ChIP-Seq_ESCs_Mouse0.86699320
151CBP_20019798_ChIP-Seq_JUKART_Human0.85908413
152IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.85908413
153VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.85645297
154TBX3_20139965_ChIP-Seq_MESCs_Mouse0.85550918
155KDM2B_26808549_Chip-Seq_DND41_Human0.84469287
156STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.84048026
157TCF3_18692474_ChIP-Seq_MESCs_Mouse0.83844819
158PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.83427352
159P300_27058665_Chip-Seq_ZR-75-30cells_Human0.81704979
160MYCN_18555785_ChIP-Seq_MESCs_Mouse0.80193108
161DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80061929
162Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.79185407
163MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.79133935
164ESR1_15608294_ChIP-ChIP_MCF-7_Human0.78592657
165POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.76989312
166ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.76721087
167NRF2_20460467_ChIP-Seq_MEFs_Mouse0.76399582

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005257_abnormal_intraocular_pressure8.00805728
2MP0004859_abnormal_synaptic_plasticity5.16754661
3MP0006292_abnormal_olfactory_placode4.52781810
4MP0008057_abnormal_DNA_replication4.50382225
5MP0002822_catalepsy3.92083846
6MP0003635_abnormal_synaptic_transmissio3.45658789
7MP0002638_abnormal_pupillary_reflex3.25351744
8MP0004782_abnormal_surfactant_physiolog3.00462022
9MP0010234_abnormal_vibrissa_follicle2.94530281
10MP0003880_abnormal_central_pattern2.93273216
11MP0002909_abnormal_adrenal_gland2.87749774
12MP0009745_abnormal_behavioral_response2.87102737
13MP0005394_taste/olfaction_phenotype2.85852766
14MP0005499_abnormal_olfactory_system2.85852766
15MP0002063_abnormal_learning/memory/cond2.80393710
16MP0008789_abnormal_olfactory_epithelium2.76151241
17MP0004270_analgesia2.65796536
18MP0003941_abnormal_skin_development2.60023681
19MP0008438_abnormal_cutaneous_collagen2.55599431
20MP0009780_abnormal_chondrocyte_physiolo2.48487810
21MP0002064_seizures2.43798278
22MP0001440_abnormal_grooming_behavior2.35894248
23MP0001968_abnormal_touch/_nociception2.27797280
24MP0002572_abnormal_emotion/affect_behav2.25401194
25MP0004858_abnormal_nervous_system2.20945409
26MP0008877_abnormal_DNA_methylation2.16478846
27MP0001958_emphysema2.14093035
28MP0009046_muscle_twitch2.13271526
29MP0001501_abnormal_sleep_pattern2.12709655
30MP0002938_white_spotting2.09890540
31MP0001177_atelectasis2.09640094
32MP0010352_gastrointestinal_tract_polyps2.03961482
33MP0003329_amyloid_beta_deposits2.02932733
34MP0008961_abnormal_basal_metabolism1.99508202
35MP0000569_abnormal_digit_pigmentation1.99402507
36MP0000428_abnormal_craniofacial_morphol1.96916941
37MP0003787_abnormal_imprinting1.79904577
38MP0002272_abnormal_nervous_system1.78651356
39MP0002736_abnormal_nociception_after1.77533394
40MP0002735_abnormal_chemical_nociception1.75322952
41MP0003890_abnormal_embryonic-extraembry1.74839218
42MP0001486_abnormal_startle_reflex1.74449923
43MP0003566_abnormal_cell_adhesion1.72105084
44MP0002734_abnormal_mechanical_nocicepti1.71532808
45MP0005167_abnormal_blood-brain_barrier1.70135605
46MP0002733_abnormal_thermal_nociception1.69162230
47MP0003283_abnormal_digestive_organ1.67517115
48MP0000613_abnormal_salivary_gland1.66175628
49MP0001348_abnormal_lacrimal_gland1.65634700
50MP0004272_abnormal_basement_membrane1.63564698
51MP0002089_abnormal_postnatal_growth/wei1.57356520
52MP0005623_abnormal_meninges_morphology1.56518783
53MP0003950_abnormal_plasma_membrane1.55822145
54MP0010678_abnormal_skin_adnexa1.54302870
55MP0004811_abnormal_neuron_physiology1.52453028
56MP0003300_gastrointestinal_ulcer1.47687950
57MP0002166_altered_tumor_susceptibility1.47323694
58MP0002557_abnormal_social/conspecific_i1.47125880
59MP0001984_abnormal_olfaction1.46041146
60MP0001970_abnormal_pain_threshold1.42697676
61MP0003077_abnormal_cell_cycle1.42611391
62MP0002009_preneoplasia1.41933842
63MP0005275_abnormal_skin_tensile1.41407106
64MP0003045_fibrosis1.40118996
65MP0005423_abnormal_somatic_nervous1.39927384
66MP0002160_abnormal_reproductive_system1.39754175
67MP0008004_abnormal_stomach_pH1.38100025
68MP0002184_abnormal_innervation1.37986244
69MP0005551_abnormal_eye_electrophysiolog1.37484940
70MP0002067_abnormal_sensory_capabilities1.35634244
71MP0003868_abnormal_feces_composition1.33927796
72MP0000003_abnormal_adipose_tissue1.32897155
73MP0005076_abnormal_cell_differentiation1.32617022
74MP0004924_abnormal_behavior1.30625630
75MP0005386_behavior/neurological_phenoty1.30625630
76MP0002697_abnormal_eye_size1.30525105
77MP0000767_abnormal_smooth_muscle1.30250724
78MP0000604_amyloidosis1.28569131
79MP0010094_abnormal_chromosome_stability1.27861136
80MP0002177_abnormal_outer_ear1.27548115
81MP0002090_abnormal_vision1.27372130
82MP0003879_abnormal_hair_cell1.25116936
83MP0000013_abnormal_adipose_tissue1.24262956
84MP0005410_abnormal_fertilization1.23568828
85MP0003705_abnormal_hypodermis_morpholog1.23559611
86MP0010307_abnormal_tumor_latency1.22963974
87MP0003111_abnormal_nucleus_morphology1.21106407
88MP0008569_lethality_at_weaning1.19665213
89MP0001730_embryonic_growth_arrest1.18332663
90MP0005360_urolithiasis1.16931376
91MP0003183_abnormal_peptide_metabolism1.16032947
92MP0004957_abnormal_blastocyst_morpholog1.14954442
93MP0005083_abnormal_biliary_tract1.13507095
94MP0002092_abnormal_eye_morphology1.12926773
95MP0000350_abnormal_cell_proliferation1.12305908
96MP0003633_abnormal_nervous_system1.11344590
97MP0005388_respiratory_system_phenotype1.10363575
98MP0002133_abnormal_respiratory_system1.10363575
99MP0000685_abnormal_immune_system1.09111280
100MP0003303_peritoneal_inflammation1.07529835
101MP0003172_abnormal_lysosome_physiology1.06373084
102MP0000955_abnormal_spinal_cord1.06319899
103MP0000383_abnormal_hair_follicle1.05545276
104MP0003935_abnormal_craniofacial_develop1.05072054
105MP0002066_abnormal_motor_capabilities/c1.03721342
106MP0002006_tumorigenesis1.03544135
107MP0003075_altered_response_to1.03015606
108MP0001502_abnormal_circadian_rhythm1.02990256
109MP0005380_embryogenesis_phenotype1.02106896
110MP0001672_abnormal_embryogenesis/_devel1.02106896
111MP0008995_early_reproductive_senescence1.01883554
112MP0001299_abnormal_eye_distance/1.01757131
113MP0003937_abnormal_limbs/digits/tail_de1.00916886
114MP0003984_embryonic_growth_retardation1.00568280
115MP0005503_abnormal_tendon_morphology1.00436391
116MP0000537_abnormal_urethra_morphology0.99797994
117MP0002882_abnormal_neuron_morphology0.99703333
118MP0008874_decreased_physiological_sensi0.99386435
119MP0004885_abnormal_endolymph0.98624975
120MP0002084_abnormal_developmental_patter0.98613775
121MP0002088_abnormal_embryonic_growth/wei0.98383696
122MP0005166_decreased_susceptibility_to0.97878744
123MP0002139_abnormal_hepatobiliary_system0.96560217
124MP0001697_abnormal_embryo_size0.96388387
125MP0001664_abnormal_digestion0.96353079
126MP0000733_abnormal_muscle_development0.94114558
127MP0005197_abnormal_uvea_morphology0.92620154
128MP0001915_intracranial_hemorrhage0.91841145
129MP0002877_abnormal_melanocyte_morpholog0.91216485
130MP0002295_abnormal_pulmonary_circulatio0.91207598
131MP0003631_nervous_system_phenotype0.91063532
132MP0000778_abnormal_nervous_system0.90475851
133MP0002229_neurodegeneration0.89100879
134MP0005621_abnormal_cell_physiology0.87091055
135MP0001944_abnormal_pancreas_morphology0.86783498
136MP0004484_altered_response_of0.85729542
137MP0002086_abnormal_extraembryonic_tissu0.85605570
138MP0001943_abnormal_respiration0.85533890
139MP0003091_abnormal_cell_migration0.85510125
140MP0004130_abnormal_muscle_cell0.85506851
141MP0005645_abnormal_hypothalamus_physiol0.84704807
142MP0009250_abnormal_appendicular_skeleto0.84429683
143MP0003634_abnormal_glial_cell0.84196579
144MP0003115_abnormal_respiratory_system0.83894411
145MP0009703_decreased_birth_body0.83252059
146MP0001346_abnormal_lacrimal_gland0.82700879
147MP0005220_abnormal_exocrine_pancreas0.82252990
148MP0004510_myositis0.82159178
149MP0000534_abnormal_ureter_morphology0.80023803
150MP0003755_abnormal_palate_morphology0.79759491
151MP0004134_abnormal_chest_morphology0.78941878
152MP0006276_abnormal_autonomic_nervous0.78838744
153MP0005535_abnormal_body_temperature0.78256600
154MP0001765_abnormal_ion_homeostasis0.77199223
155MP0010386_abnormal_urinary_bladder0.77175856
156MP0005187_abnormal_penis_morphology0.76373068
157MP0001666_abnormal_nutrient_absorption0.75429394
158MP0000432_abnormal_head_morphology0.75166159
159MP0004233_abnormal_muscle_weight0.74832397
160MP0002152_abnormal_brain_morphology0.74669231
161MP0003252_abnormal_bile_duct0.74557141
162MP0008872_abnormal_physiological_respon0.74468510
163MP0002925_abnormal_cardiovascular_devel0.74397680
164MP0002069_abnormal_eating/drinking_beha0.73089383
165MP0001286_abnormal_eye_development0.72347720
166MP0003385_abnormal_body_wall0.71619316
167MP0004085_abnormal_heartbeat0.71332656
168MP0002085_abnormal_embryonic_tissue0.69876281
169MP0005248_abnormal_Harderian_gland0.69241746
170MP0010329_abnormal_lipoprotein_level0.68822184
171MP0001340_abnormal_eyelid_morphology0.68470673
172MP0005408_hypopigmentation0.67835048
173MP0002080_prenatal_lethality0.67433706
174MP0002138_abnormal_hepatobiliary_system0.67369049
175MP0004197_abnormal_fetal_growth/weight/0.67320524
176MP0003632_abnormal_nervous_system0.67218208
177MP0003693_abnormal_embryo_hatching0.65749191
178MP0003699_abnormal_female_reproductive0.65051559
179MP0010368_abnormal_lymphatic_system0.64091854
180MP0004808_abnormal_hematopoietic_stem0.63137540
181MP0001879_abnormal_lymphatic_vessel0.62959537
182MP0010030_abnormal_orbit_morphology0.60893177
183MP0002233_abnormal_nose_morphology0.60823074
184MP0005384_cellular_phenotype0.59907521
185MP0001186_pigmentation_phenotype0.57947358

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the fovea (HP:0008060)5.73008203
2Hypoplasia of the fovea (HP:0007750)5.73008203
3Interstitial pulmonary disease (HP:0006530)4.87739633
4Abnormality of the fovea (HP:0000493)4.78490982
5Focal motor seizures (HP:0011153)4.36823283
6Visual hallucinations (HP:0002367)4.26004581
7Focal seizures (HP:0007359)4.16235095
8Myokymia (HP:0002411)4.13620176
9Aplasia/Hypoplasia of the macula (HP:0008059)3.91659597
10Aplasia/Hypoplasia affecting the retina (HP:0008061)3.54248986
11Gastrointestinal stroma tumor (HP:0100723)3.48476085
12Cerebral inclusion bodies (HP:0100314)3.47390278
13Supranuclear gaze palsy (HP:0000605)3.46205466
14Action tremor (HP:0002345)3.42458788
15Resting tremor (HP:0002322)3.40857015
16Papillary thyroid carcinoma (HP:0002895)3.37561033
17Difficulty running (HP:0009046)3.34242968
18Absence seizures (HP:0002121)3.22732250
19Atonic seizures (HP:0010819)3.21374439
20IgA deficiency (HP:0002720)3.07125129
21Achilles tendon contracture (HP:0001771)3.06780338
22Abnormality of the lower motor neuron (HP:0002366)3.02728575
23Mask-like facies (HP:0000298)3.00610076
24Neurofibrillary tangles (HP:0002185)3.00317189
25Papilledema (HP:0001085)2.96560770
26Progressive cerebellar ataxia (HP:0002073)2.86499625
27Dialeptic seizures (HP:0011146)2.81519456
28Abnormality of the Achilles tendon (HP:0005109)2.77995922
29Neonatal short-limb short stature (HP:0008921)2.73903730
30Febrile seizures (HP:0002373)2.73356231
31Truncal ataxia (HP:0002078)2.72963722
32Abnormality of the fingertips (HP:0001211)2.72072926
33Medulloblastoma (HP:0002885)2.69647214
34Congenital glaucoma (HP:0001087)2.68924991
35Generalized tonic-clonic seizures (HP:0002069)2.66603474
36Premature rupture of membranes (HP:0001788)2.60042539
37Knee flexion contracture (HP:0006380)2.56203461
38Uterine leiomyosarcoma (HP:0002891)2.52803368
39Leiomyosarcoma (HP:0100243)2.52803368
40Depression (HP:0000716)2.51960025
41Epileptic encephalopathy (HP:0200134)2.51438237
42Chronic bronchitis (HP:0004469)2.50784445
43Tachypnea (HP:0002789)2.50090555
44Hyperactive renin-angiotensin system (HP:0000841)2.48615608
45Overlapping toe (HP:0001845)2.43140254
46Postural instability (HP:0002172)2.42831068
47Tubulointerstitial fibrosis (HP:0005576)2.42322023
48Protrusio acetabuli (HP:0003179)2.40900239
49Amblyopia (HP:0000646)2.39841863
50Relative macrocephaly (HP:0004482)2.39657223
51Optic nerve coloboma (HP:0000588)2.37958874
52Hypoventilation (HP:0002791)2.37185743
53Limited hip movement (HP:0008800)2.37049244
54Long toe (HP:0010511)2.36294806
55Impaired vibration sensation in the lower limbs (HP:0002166)2.35451599
56Emphysema (HP:0002097)2.35408345
57Viral hepatitis (HP:0006562)2.34869871
58Cerebral aneurysm (HP:0004944)2.34182574
59Recurrent sinusitis (HP:0011108)2.33266179
60Rapidly progressive (HP:0003678)2.32437986
61Termporal pattern (HP:0011008)2.31944823
62Insidious onset (HP:0003587)2.31944823
63Agammaglobulinemia (HP:0004432)2.29328712
64Colitis (HP:0002583)2.29187457
65Dysdiadochokinesis (HP:0002075)2.29092349
66Overgrowth (HP:0001548)2.28825761
67Abnormal social behavior (HP:0012433)2.27418565
68Impaired social interactions (HP:0000735)2.27418565
69Subacute progressive viral hepatitis (HP:0006572)2.26994032
70Dysmetric saccades (HP:0000641)2.26743821
71Heterotopia (HP:0002282)2.26652562
72Anxiety (HP:0000739)2.26126805
73Thoracolumbar scoliosis (HP:0002944)2.25591119
74Urinary bladder sphincter dysfunction (HP:0002839)2.22891483
75Megalencephaly (HP:0001355)2.22692365
76Hip contracture (HP:0003273)2.22544634
77Persistence of primary teeth (HP:0006335)2.21533018
78Amyotrophic lateral sclerosis (HP:0007354)2.21246710
79Urinary urgency (HP:0000012)2.20786705
80Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.19926784
81Gout (HP:0001997)2.17851958
82Macroorchidism (HP:0000053)2.16816356
83Mutism (HP:0002300)2.16685437
84Osteolytic defects of the phalanges of the hand (HP:0009771)2.13041179
85Osteolytic defects of the hand bones (HP:0009699)2.13041179
86Ankyloglossia (HP:0010296)2.12201545
87Ventricular fibrillation (HP:0001663)2.09737495
88Excessive salivation (HP:0003781)2.09024766
89Drooling (HP:0002307)2.09024766
90Down-sloping shoulders (HP:0200021)2.07547183
91Poor eye contact (HP:0000817)2.07215511
92Bradykinesia (HP:0002067)2.03190467
93Aortic dissection (HP:0002647)2.02828598
94Central scotoma (HP:0000603)2.02711574
95Annular pancreas (HP:0001734)2.02605020
96Hemiplegia (HP:0002301)2.01876620
97Biliary tract neoplasm (HP:0100574)2.01827444
98Buphthalmos (HP:0000557)2.01806043
99Hematochezia (HP:0002573)1.99445035
100Chin dimple (HP:0010751)1.99347544
101Renal duplication (HP:0000075)1.96822145
102Chromsome breakage (HP:0040012)1.96421139
103Hypercortisolism (HP:0001578)1.95992366
104Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.95390525
105IgM deficiency (HP:0002850)1.93638622
106Missing ribs (HP:0000921)1.92807308
107Generalized hyperpigmentation (HP:0007440)1.90750579
108Aortic aneurysm (HP:0004942)1.90664241
109Gaze-evoked nystagmus (HP:0000640)1.89737722
110Status epilepticus (HP:0002133)1.89097703
111Dysmetria (HP:0001310)1.88907902
112Abnormality of ocular smooth pursuit (HP:0000617)1.88640217
113Elfin facies (HP:0004428)1.88553998
114Impaired smooth pursuit (HP:0007772)1.88243949
115Decreased lacrimation (HP:0000633)1.88036796
116Polycythemia (HP:0001901)1.87909638
117Hyperkalemia (HP:0002153)1.87859263
118Renovascular hypertension (HP:0100817)1.87737469
119Abnormal pancreas size (HP:0012094)1.87334168
120Abnormality of oral frenula (HP:0000190)1.86469791
121Menstrual irregularities (HP:0000858)1.86421768
122Increased nuchal translucency (HP:0010880)1.86132064
123Hyperacusis (HP:0010780)1.85048841
124Lower limb asymmetry (HP:0100559)1.84510394
125Hand muscle atrophy (HP:0009130)1.84452214
126Torticollis (HP:0000473)1.83974011
127Upper limb amyotrophy (HP:0009129)1.83414362
128Distal upper limb amyotrophy (HP:0007149)1.83414362
129Gastrointestinal carcinoma (HP:0002672)1.83043205
130Malignant gastrointestinal tract tumors (HP:0006749)1.83043205
131Abnormality of the intrinsic pathway (HP:0010989)1.82558079
132Thyroid carcinoma (HP:0002890)1.81856708
133Hyperventilation (HP:0002883)1.81607667
134Bladder diverticulum (HP:0000015)1.81474373
135Limb dystonia (HP:0002451)1.81298263
136Neuronal loss in central nervous system (HP:0002529)1.80794121
137Ankle clonus (HP:0011448)1.80657797
138Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.80456538
139Aqueductal stenosis (HP:0002410)1.80453874
140Intention tremor (HP:0002080)1.79425945
141Mild short stature (HP:0003502)1.79292517
142Deep philtrum (HP:0002002)1.79101881
143Hemiparesis (HP:0001269)1.79048814
144Stereotypic behavior (HP:0000733)1.78593593
145Sandal gap (HP:0001852)1.78226930
146Global brain atrophy (HP:0002283)1.77724543
147Broad-based gait (HP:0002136)1.77003754
148Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.76974614
149Aplasia involving bones of the extremities (HP:0009825)1.76854182
150Aplasia involving bones of the upper limbs (HP:0009823)1.76854182
151Aplasia of the phalanges of the hand (HP:0009802)1.76854182
152Gait ataxia (HP:0002066)1.74481484
153Genetic anticipation (HP:0003743)1.74385730
154Wormian bones (HP:0002645)1.73547258
155Arterial tortuosity (HP:0005116)1.73526063
156Uterine neoplasm (HP:0010784)1.71737325
157Overriding aorta (HP:0002623)1.71619301
158Epileptiform EEG discharges (HP:0011182)1.71389896
159Narrow palate (HP:0000189)1.71356189
160Recurrent bronchitis (HP:0002837)1.70880484
161Increased CSF protein (HP:0002922)1.70478783
162Inappropriate behavior (HP:0000719)1.69568317
163EEG with generalized epileptiform discharges (HP:0011198)1.68641476
164Abnormality of the distal phalanx of the thumb (HP:0009617)1.68636078
165Abnormality of the epiphyses of the hand (HP:0005924)1.68242311
166Visceral angiomatosis (HP:0100761)1.67775737
167Transitional cell carcinoma of the bladder (HP:0006740)1.67720296
168Abnormal eating behavior (HP:0100738)1.66838264
169Hepatoblastoma (HP:0002884)1.66154579
170Progressive inability to walk (HP:0002505)1.65353462
171Vascular tortuosity (HP:0004948)1.65101371
172Scanning speech (HP:0002168)1.63895707
173Hypotension (HP:0002615)1.63796892
174Scapular winging (HP:0003691)1.63548657
175Neoplasm of striated muscle (HP:0009728)1.63444806
176Dental malocclusion (HP:0000689)1.63299786
177Postural tremor (HP:0002174)1.63213629
178Cerebral hemorrhage (HP:0001342)1.63164707
179Small epiphyses (HP:0010585)1.63119816
180Advanced eruption of teeth (HP:0006288)1.62860408
181Rhabdomyosarcoma (HP:0002859)1.62799524
182Chromosomal breakage induced by crosslinking agents (HP:0003221)1.62704890
183Progressive sensorineural hearing impairment (HP:0000408)1.62151324
184Hip dysplasia (HP:0001385)1.62060062
185Hemangiomatosis (HP:0007461)1.61918605
186Congenital stationary night blindness (HP:0007642)1.61654491
187Impaired vibratory sensation (HP:0002495)1.61240313
188Wide anterior fontanel (HP:0000260)1.60480227
189Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.60348445
190Germ cell neoplasia (HP:0100728)1.58590017
191Bladder carcinoma (HP:0002862)1.57473172
192Bladder neoplasm (HP:0009725)1.57473172
193Abnormality of chromosome segregation (HP:0002916)1.55527742
194Insomnia (HP:0100785)1.53563630

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK94.32478612
2MAP3K93.70665061
3NTRK33.28620329
4EIF2AK33.16319557
5EPHA42.91359085
6MAP3K42.51172885
7CDK122.50846417
8KSR22.48255098
9PRPF4B2.32038435
10TRIB32.22903648
11NTRK12.17104948
12DAPK22.16420812
13PRKD32.15743527
14RIPK12.12746460
15STK38L2.09408431
16RIPK42.01606185
17CAMKK12.00989434
18LATS11.93422354
19MINK11.90086498
20WEE11.89595771
21MAP3K21.83516792
22MAPK131.75483739
23PKN21.74177579
24LATS21.68679553
25STK31.66240499
26MAP2K41.64214532
27CAMK1G1.60492010
28SIK21.58066638
29MARK11.57682078
30RET1.56911508
31SCYL21.56210184
32MELK1.56158957
33FGFR21.54148234
34AKT31.52738404
35RPS6KB21.47196325
36NTRK21.44441280
37TYRO31.43803195
38KSR11.41372090
39FRK1.39483780
40TTK1.36482999
41MET1.32226336
42BRSK21.32092497
43PRKCH1.29803107
44PAK61.27915487
45LMTK21.26978542
46PNCK1.26350647
47PDGFRB1.26274031
48FES1.25680611
49PDGFRA1.24738204
50BRD41.24713336
51CAMKK21.21592364
52PTK2B1.20542694
53IRAK21.19635553
54TRPM71.19241136
55CDC71.17699578
56STK381.15164057
57MAP2K71.09872368
58PDK31.09499818
59PDK41.09499818
60CDK51.09137114
61GRK61.08191749
62SGK31.06984070
63MAP3K131.03054952
64BRAF1.02785858
65MAP3K121.02635641
66SMG10.99485364
67GRK50.99066019
68PDK10.96702745
69PLK20.95387355
70LRRK20.94643349
71DAPK10.93295678
72TAOK10.90402838
73CAMK1D0.90180148
74MAP3K10.89715158
75MAP3K140.89701249
76CDK30.89680678
77MAPK70.89607498
78PDPK10.87237218
79NEK20.85595403
80ARAF0.85179201
81PTK60.83991996
82ALK0.79904641
83MTOR0.77381744
84BMX0.76941735
85MST40.76184831
86BMPR20.75137753
87YES10.72867318
88RPS6KB10.72559258
89STK110.72379952
90ICK0.72025427
91FGFR30.71544036
92WNK10.70479156
93MAPK110.68805573
94STK240.68367895
95MAP3K100.68240736
96SGK20.68090571
97CHEK10.67868193
98MAP2K10.67838712
99FER0.67137013
100PRKCQ0.66594970
101BUB10.65872571
102PRKCG0.63776714
103EEF2K0.63355208
104TNIK0.62664226
105MAP3K80.62357878
106FGR0.61487464
107MARK20.60711403
108MST1R0.60118545
109CSNK1G20.58981469
110PAK20.57661894
111MAP3K70.57416681
112JAK10.57163208
113FYN0.56494352
114SGK10.56139917
115SGK4940.56001103
116SGK2230.56001103
117TESK10.54375212
118PAK30.54177082
119PTK20.52367849
120AKT20.51692998
121PRKCZ0.51588160
122DDR20.50746576
123PLK40.49892701
124CAMK2A0.48886339
125RAF10.48393615
126FGFR10.48005480
127CDC42BPA0.47851838
128BCR0.46031505
129PASK0.45466310
130WNK40.44719067
131EGFR0.44595142
132NEK60.44121420
133RPS6KA30.43806062
134TTN0.43448825
135ZAP700.43331070
136HIPK20.42179706
137CHEK20.40917008
138DMPK0.40573722
139RPS6KA20.40430059
140NEK10.40343463
141MOS0.38187267
142CDK70.37992841
143CDK150.37897317
144CDK180.37555510
145MAPK120.37495871
146STK100.37063265
147PDK20.36734528
148CDK140.36547074
149FGFR40.36380989
150BRSK10.35821161
151CDK20.35433597
152MAPK100.35260945
153PRKCB0.35076264
154ATM0.34720977
155CDK60.33941458
156CDK10.28893393
157GSK3B0.28446698
158PRKCI0.27741678
159SRPK10.26809219

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053222.34824259
2Olfactory transduction_Homo sapiens_hsa047402.34744884
3Nicotine addiction_Homo sapiens_hsa050332.31354403
4Synaptic vesicle cycle_Homo sapiens_hsa047212.30218536
5Long-term potentiation_Homo sapiens_hsa047202.20819527
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.07689514
7Small cell lung cancer_Homo sapiens_hsa052222.04680894
8Cell cycle_Homo sapiens_hsa041102.00895117
9Amphetamine addiction_Homo sapiens_hsa050311.96037131
10Circadian entrainment_Homo sapiens_hsa047131.93621920
11GABAergic synapse_Homo sapiens_hsa047271.90013831
12Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.86237439
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.85800126
14Morphine addiction_Homo sapiens_hsa050321.85712710
15Salivary secretion_Homo sapiens_hsa049701.84332053
16Adherens junction_Homo sapiens_hsa045201.81053465
17Dopaminergic synapse_Homo sapiens_hsa047281.80798961
18ECM-receptor interaction_Homo sapiens_hsa045121.77545174
19Renin secretion_Homo sapiens_hsa049241.77299922
20Glutamatergic synapse_Homo sapiens_hsa047241.76848676
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.74082633
22Gastric acid secretion_Homo sapiens_hsa049711.74074742
23Insulin secretion_Homo sapiens_hsa049111.66342800
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.65205362
25Cholinergic synapse_Homo sapiens_hsa047251.64730922
26MicroRNAs in cancer_Homo sapiens_hsa052061.62827796
27Prostate cancer_Homo sapiens_hsa052151.60152130
28Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.56294485
29Cocaine addiction_Homo sapiens_hsa050301.46364377
30Proteoglycans in cancer_Homo sapiens_hsa052051.46045326
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.44252432
32Taste transduction_Homo sapiens_hsa047421.39495863
33TGF-beta signaling pathway_Homo sapiens_hsa043501.37360529
34Nitrogen metabolism_Homo sapiens_hsa009101.36283050
35Dorso-ventral axis formation_Homo sapiens_hsa043201.34845690
36Viral carcinogenesis_Homo sapiens_hsa052031.34255221
37Oxytocin signaling pathway_Homo sapiens_hsa049211.33666466
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.33098423
39GnRH signaling pathway_Homo sapiens_hsa049121.32914120
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.32474306
41p53 signaling pathway_Homo sapiens_hsa041151.30691687
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.30575019
43Colorectal cancer_Homo sapiens_hsa052101.29841112
44Type II diabetes mellitus_Homo sapiens_hsa049301.29177434
45Glioma_Homo sapiens_hsa052141.28618999
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.27584372
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.25852256
48Estrogen signaling pathway_Homo sapiens_hsa049151.24364019
49Long-term depression_Homo sapiens_hsa047301.22963118
50Carbohydrate digestion and absorption_Homo sapiens_hsa049731.22447077
51Phototransduction_Homo sapiens_hsa047441.19234824
52mRNA surveillance pathway_Homo sapiens_hsa030151.17274965
53Gap junction_Homo sapiens_hsa045401.15381682
54Pentose phosphate pathway_Homo sapiens_hsa000301.15010457
55Hippo signaling pathway_Homo sapiens_hsa043901.14494664
56Measles_Homo sapiens_hsa051621.13594914
57NF-kappa B signaling pathway_Homo sapiens_hsa040641.13538851
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.12989539
59Basal cell carcinoma_Homo sapiens_hsa052171.12879354
60Bile secretion_Homo sapiens_hsa049761.11771447
61HTLV-I infection_Homo sapiens_hsa051661.11181307
62Hepatitis B_Homo sapiens_hsa051611.11167708
63Intestinal immune network for IgA production_Homo sapiens_hsa046721.10702346
64Influenza A_Homo sapiens_hsa051641.09427526
65Calcium signaling pathway_Homo sapiens_hsa040201.08834580
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.07781412
67Thyroid cancer_Homo sapiens_hsa052161.06967515
68cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06178662
69Thyroid hormone synthesis_Homo sapiens_hsa049181.05886521
70Vitamin B6 metabolism_Homo sapiens_hsa007501.04795308
71Herpes simplex infection_Homo sapiens_hsa051681.04322191
72Autoimmune thyroid disease_Homo sapiens_hsa053201.03918073
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00223395
74cAMP signaling pathway_Homo sapiens_hsa040240.99484771
75Serotonergic synapse_Homo sapiens_hsa047260.99407586
76Mineral absorption_Homo sapiens_hsa049780.98220868
77Collecting duct acid secretion_Homo sapiens_hsa049660.97640674
78VEGF signaling pathway_Homo sapiens_hsa043700.95051919
79RNA transport_Homo sapiens_hsa030130.93490345
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91200950
81Viral myocarditis_Homo sapiens_hsa054160.90936102
82Circadian rhythm_Homo sapiens_hsa047100.88528040
83Apoptosis_Homo sapiens_hsa042100.88435211
84ErbB signaling pathway_Homo sapiens_hsa040120.86584572
85Nucleotide excision repair_Homo sapiens_hsa034200.86203974
86Hedgehog signaling pathway_Homo sapiens_hsa043400.85996971
87DNA replication_Homo sapiens_hsa030300.84980997
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.84244049
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84097094
90Glucagon signaling pathway_Homo sapiens_hsa049220.83931484
91FoxO signaling pathway_Homo sapiens_hsa040680.83454577
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81982776
93Lysine degradation_Homo sapiens_hsa003100.81557329
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.80543759
95Melanogenesis_Homo sapiens_hsa049160.80363790
96Pathways in cancer_Homo sapiens_hsa052000.79855885
97Vibrio cholerae infection_Homo sapiens_hsa051100.79693423
98Bladder cancer_Homo sapiens_hsa052190.79334454
99Pancreatic secretion_Homo sapiens_hsa049720.79278926
100Hepatitis C_Homo sapiens_hsa051600.76962845
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.76421830
102Non-small cell lung cancer_Homo sapiens_hsa052230.76271887
103Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76027365
104Inositol phosphate metabolism_Homo sapiens_hsa005620.75869145
105Allograft rejection_Homo sapiens_hsa053300.75719277
106Mismatch repair_Homo sapiens_hsa034300.75107155
107mTOR signaling pathway_Homo sapiens_hsa041500.74760068
108Fatty acid biosynthesis_Homo sapiens_hsa000610.74416078
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73623979
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72314873
111Toxoplasmosis_Homo sapiens_hsa051450.71680673
112PI3K-Akt signaling pathway_Homo sapiens_hsa041510.71328496
113Choline metabolism in cancer_Homo sapiens_hsa052310.67878883
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67447110
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66974101
116Epstein-Barr virus infection_Homo sapiens_hsa051690.66584140
117HIF-1 signaling pathway_Homo sapiens_hsa040660.65649522
118Melanoma_Homo sapiens_hsa052180.64968560
119Tight junction_Homo sapiens_hsa045300.64652812
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.64589530
121Endometrial cancer_Homo sapiens_hsa052130.64529945
122Wnt signaling pathway_Homo sapiens_hsa043100.63962196
123Protein digestion and absorption_Homo sapiens_hsa049740.63889199
124Renal cell carcinoma_Homo sapiens_hsa052110.63513605
125Axon guidance_Homo sapiens_hsa043600.63511267
126B cell receptor signaling pathway_Homo sapiens_hsa046620.63444367
127Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63372468
128Rap1 signaling pathway_Homo sapiens_hsa040150.63365905
129Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61936516
130Other glycan degradation_Homo sapiens_hsa005110.61701372
131Endocytosis_Homo sapiens_hsa041440.61335432
132Platelet activation_Homo sapiens_hsa046110.58634285
133MAPK signaling pathway_Homo sapiens_hsa040100.58241773
134Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58083264
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58032185
136Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.57507133
137N-Glycan biosynthesis_Homo sapiens_hsa005100.57278774
138Dilated cardiomyopathy_Homo sapiens_hsa054140.56484898
139Insulin signaling pathway_Homo sapiens_hsa049100.56450953
140Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55053092
141Steroid biosynthesis_Homo sapiens_hsa001000.55009477
142Sphingolipid signaling pathway_Homo sapiens_hsa040710.53008103
143Prion diseases_Homo sapiens_hsa050200.52744926
144Graft-versus-host disease_Homo sapiens_hsa053320.52659252
145Non-homologous end-joining_Homo sapiens_hsa034500.51789398
146Arginine biosynthesis_Homo sapiens_hsa002200.51611772
147AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51136299
148Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50959952
149Prolactin signaling pathway_Homo sapiens_hsa049170.50748399
150Oocyte meiosis_Homo sapiens_hsa041140.49206864
151Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48202120
152Pancreatic cancer_Homo sapiens_hsa052120.45352044
153Insulin resistance_Homo sapiens_hsa049310.44996716
154Adipocytokine signaling pathway_Homo sapiens_hsa049200.44930962
155Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44825796
156Alcoholism_Homo sapiens_hsa050340.44567452
157Chemokine signaling pathway_Homo sapiens_hsa040620.43728554
158Chronic myeloid leukemia_Homo sapiens_hsa052200.42538549
159Focal adhesion_Homo sapiens_hsa045100.41251629
160Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40184886
161Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40105456
162Amoebiasis_Homo sapiens_hsa051460.39835195
163Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39652348
164T cell receptor signaling pathway_Homo sapiens_hsa046600.39431328

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