SNX25P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)8.76116219
2NIK/NF-kappaB signaling (GO:0038061)7.41655854
3ribosomal small subunit assembly (GO:0000028)5.97635539
4DNA methylation involved in gamete generation (GO:0043046)5.76441632
5positive regulation of interleukin-8 biosynthetic process (GO:0045416)5.18153795
6RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)5.01918586
7tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)5.01918586
8gonadal mesoderm development (GO:0007506)5.00580459
9centriole assembly (GO:0098534)4.91935803
10poly(A)+ mRNA export from nucleus (GO:0016973)4.80861778
11centriole replication (GO:0007099)4.70769161
12viral transcription (GO:0019083)4.70661700
13ribosomal small subunit biogenesis (GO:0042274)4.65149546
14ribosomal large subunit biogenesis (GO:0042273)4.63061657
15pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.54869865
16translational termination (GO:0006415)4.54555348
17establishment of protein localization to mitochondrial membrane (GO:0090151)4.48656157
18SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.47132069
19meiotic chromosome segregation (GO:0045132)4.46944868
20cotranslational protein targeting to membrane (GO:0006613)4.40108103
21protein targeting to ER (GO:0045047)4.38881450
22I-kappaB phosphorylation (GO:0007252)4.28604689
23establishment of protein localization to endoplasmic reticulum (GO:0072599)4.22631452
24regulation of mitochondrial translation (GO:0070129)4.21760660
25protein localization to endoplasmic reticulum (GO:0070972)4.14486520
26regulation of double-strand break repair via homologous recombination (GO:0010569)4.07092949
27prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.91635084
28translational initiation (GO:0006413)3.83794619
29pyrimidine nucleotide catabolic process (GO:0006244)3.81807587
30coenzyme A biosynthetic process (GO:0015937)3.80888640
31translational elongation (GO:0006414)3.78054985
32regulation of interferon-beta biosynthetic process (GO:0045357)3.64171056
33pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.63041035
34daunorubicin metabolic process (GO:0044597)3.60654412
35polyketide metabolic process (GO:0030638)3.60654412
36doxorubicin metabolic process (GO:0044598)3.60654412
37nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.55167456
38viral life cycle (GO:0019058)3.50255572
39positive regulation by symbiont of host defense response (GO:0052509)3.48274675
40modulation by symbiont of host defense response (GO:0052031)3.48274675
41modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.48274675
42modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.48274675
43positive regulation by organism of defense response of other organism involved in symbiotic interact3.48274675
44modulation by symbiont of host immune response (GO:0052553)3.48274675
45maturation of 5.8S rRNA (GO:0000460)3.45196309
46B cell proliferation (GO:0042100)3.37618017
47cellular protein complex disassembly (GO:0043624)3.34191590
48mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.28608973
49gene silencing by RNA (GO:0031047)3.27738627
50mitochondrion morphogenesis (GO:0070584)3.23043365
51pyrimidine dimer repair (GO:0006290)3.21620890
52negative regulation of DNA repair (GO:0045738)3.19935194
53formation of translation preinitiation complex (GO:0001731)3.17702914
54ribonucleoprotein complex biogenesis (GO:0022613)3.17286346
55aminoglycoside antibiotic metabolic process (GO:0030647)3.17222798
56resolution of meiotic recombination intermediates (GO:0000712)3.14785801
57cranial suture morphogenesis (GO:0060363)3.13260941
58pantothenate metabolic process (GO:0015939)3.13242417
59segment specification (GO:0007379)3.11211661
60positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.09414179
61embryonic viscerocranium morphogenesis (GO:0048703)3.09252169
62establishment of integrated proviral latency (GO:0075713)3.05515067
63lipopolysaccharide biosynthetic process (GO:0009103)3.01290122
64protein neddylation (GO:0045116)2.97992092
65respiratory chain complex IV assembly (GO:0008535)2.96544301
66purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.96272111
67ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.96272111
68nucleoside bisphosphate biosynthetic process (GO:0033866)2.96272111
69negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.94223395
70protein targeting to membrane (GO:0006612)2.91646477
71regulation of interleukin-8 biosynthetic process (GO:0045414)2.91645060
72translation (GO:0006412)2.91521918
73inner mitochondrial membrane organization (GO:0007007)2.90622870
74regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.84237915
75regulation of acrosome reaction (GO:0060046)2.84091655
76establishment of viral latency (GO:0019043)2.81742408
77synaptonemal complex assembly (GO:0007130)2.80651464
78protein complex disassembly (GO:0043241)2.80051436
79aerobic respiration (GO:0009060)2.77124943
80exocrine pancreas development (GO:0031017)2.76270602
81regulation of Golgi to plasma membrane protein transport (GO:0042996)2.72426588
82electron transport chain (GO:0022900)2.72055216
83respiratory electron transport chain (GO:0022904)2.70921988
84macromolecular complex disassembly (GO:0032984)2.70831527
85mannosylation (GO:0097502)2.69561887
86motile cilium assembly (GO:0044458)2.69067174
87cytochrome complex assembly (GO:0017004)2.62864440
88craniofacial suture morphogenesis (GO:0097094)2.61575826
89lung-associated mesenchyme development (GO:0060484)2.61087656
90regulation of helicase activity (GO:0051095)2.59414322
91cellular component biogenesis (GO:0044085)2.57757493
92fusion of sperm to egg plasma membrane (GO:0007342)2.56976456
93GDP-mannose metabolic process (GO:0019673)2.55689822
94DNA synthesis involved in DNA repair (GO:0000731)2.55178442
95galactose metabolic process (GO:0006012)2.54942907
96CENP-A containing nucleosome assembly (GO:0034080)2.54817954
97anterior/posterior axis specification, embryo (GO:0008595)2.53381780
98nuclear-transcribed mRNA catabolic process (GO:0000956)2.52944375
99mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.52625570
100proteasome assembly (GO:0043248)2.51213174

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.42861539
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.37093887
3ZNF263_19887448_ChIP-Seq_K562_Human4.33773407
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.76566520
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.23515087
6IGF1R_20145208_ChIP-Seq_DFB_Human3.20091861
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.07958235
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.06648129
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.96431057
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.90687832
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.86736645
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.62151811
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.60380235
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.53457614
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.52198852
16ZNF274_21170338_ChIP-Seq_K562_Hela2.51879674
17PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.47156298
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.42709627
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.39005279
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.36126465
21DCP1A_22483619_ChIP-Seq_HELA_Human2.27114584
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.26118721
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.25088967
24E2F1_21310950_ChIP-Seq_MCF-7_Human2.24200653
25POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.19277107
26FOXP3_21729870_ChIP-Seq_TREG_Human2.15759068
27XRN2_22483619_ChIP-Seq_HELA_Human2.11135814
28GABP_19822575_ChIP-Seq_HepG2_Human2.07483389
29NELFA_20434984_ChIP-Seq_ESCs_Mouse2.05529625
30HIF1A_21447827_ChIP-Seq_MCF-7_Human1.97992381
31YY1_21170310_ChIP-Seq_MESCs_Mouse1.88432008
32E2F4_17652178_ChIP-ChIP_JURKAT_Human1.83895941
33TP63_19390658_ChIP-ChIP_HaCaT_Human1.79795164
34MYC_18940864_ChIP-ChIP_HL60_Human1.78585723
35TTF2_22483619_ChIP-Seq_HELA_Human1.76328813
36POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.71447116
37ELK1_19687146_ChIP-ChIP_HELA_Human1.67892421
38AR_21909140_ChIP-Seq_LNCAP_Human1.63764798
39ZFX_18555785_ChIP-Seq_MESCs_Mouse1.63490317
40VDR_23849224_ChIP-Seq_CD4+_Human1.59599448
41HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.59591010
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.55673523
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.55575048
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.53969421
45PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.53117330
46DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.50107558
47E2F7_22180533_ChIP-Seq_HELA_Human1.48434995
48ELK1_22589737_ChIP-Seq_MCF10A_Human1.45244323
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42165385
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39278210
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38707597
52FUS_26573619_Chip-Seq_HEK293_Human1.38427124
53ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.37659817
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36220925
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35601134
56KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.35140176
57HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.31416782
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29262699
59ELF5_23300383_ChIP-Seq_T47D_Human1.28264198
60SRF_21415370_ChIP-Seq_HL-1_Mouse1.26787732
61EOMES_21245162_ChIP-Seq_HESCs_Human1.26565818
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24801935
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21861160
64CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.21209280
65GATA1_26923725_Chip-Seq_HPCs_Mouse1.20965977
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19399496
67CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.17847327
68TP53_22573176_ChIP-Seq_HFKS_Human1.17727202
69EWS_26573619_Chip-Seq_HEK293_Human1.14694305
70SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.13097078
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11044545
72EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.09876364
73NANOG_16153702_ChIP-ChIP_HESCs_Human1.07349011
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07339982
75SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06521578
76ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05156440
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01797144
78HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99639430
79IRF8_22096565_ChIP-ChIP_GC-B_Human0.99386072
80FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97840082
81FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97144313
82FOXA1_25329375_ChIP-Seq_VCAP_Human0.97144313
83PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.95017574
84SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93615401
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93378743
86ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92303801
87SOX17_20123909_ChIP-Seq_XEN_Mouse0.89282713
88TCF3_18692474_ChIP-Seq_MEFs_Mouse0.87481452
89CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.86410375
90KDM5A_27292631_Chip-Seq_BREAST_Human0.85846329
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85275901
92CIITA_25753668_ChIP-Seq_RAJI_Human0.83502433
93POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.83132334
94CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.82495319
95ESR1_21235772_ChIP-Seq_MCF-7_Human0.82339149
96REST_19997604_ChIP-ChIP_NEURONS_Mouse0.82150797
97NANOG_18555785_ChIP-Seq_MESCs_Mouse0.81057258
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.80516379
99FOXM1_26456572_ChIP-Seq_MCF-7_Human0.80472003
100PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.79485894

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation5.40999269
2MP0002102_abnormal_ear_morphology5.05644974
3MP0002138_abnormal_hepatobiliary_system4.25673470
4MP0001348_abnormal_lacrimal_gland4.02607404
5MP0005379_endocrine/exocrine_gland_phen3.32430682
6MP0003890_abnormal_embryonic-extraembry3.05811111
7MP0008995_early_reproductive_senescence2.96664525
8MP0010030_abnormal_orbit_morphology2.83991516
9MP0001661_extended_life_span2.65647193
10MP0003183_abnormal_peptide_metabolism2.65211543
11MP0002638_abnormal_pupillary_reflex2.34709556
12MP0003786_premature_aging2.12300256
13MP0002163_abnormal_gland_morphology2.03345536
14MP0004133_heterotaxia1.91171420
15MP0004957_abnormal_blastocyst_morpholog1.89791409
16MP0003950_abnormal_plasma_membrane1.79193035
17MP0006292_abnormal_olfactory_placode1.77778666
18MP0008058_abnormal_DNA_repair1.72641744
19MP0001529_abnormal_vocalization1.65719140
20MP0005084_abnormal_gallbladder_morpholo1.65013552
21MP0009384_cardiac_valve_regurgitation1.63983487
22MP0000537_abnormal_urethra_morphology1.61547471
23MP0002210_abnormal_sex_determination1.61492165
24MP0001764_abnormal_homeostasis1.60870851
25MP0003077_abnormal_cell_cycle1.57783109
26MP0000015_abnormal_ear_pigmentation1.54572761
27MP0000383_abnormal_hair_follicle1.52388428
28MP0003252_abnormal_bile_duct1.51429312
29MP0005257_abnormal_intraocular_pressure1.50618546
30MP0001727_abnormal_embryo_implantation1.49224672
31MP0002928_abnormal_bile_duct1.47748356
32MP0003119_abnormal_digestive_system1.42469561
33MP0005187_abnormal_penis_morphology1.40376464
34MP0001145_abnormal_male_reproductive1.32975249
35MP0004264_abnormal_extraembryonic_tissu1.28437392
36MP0003718_maternal_effect1.27980435
37MP0000653_abnormal_sex_gland1.20935079
38MP0000428_abnormal_craniofacial_morphol1.18449322
39MP0003195_calcinosis1.11275968
40MP0000762_abnormal_tongue_morphology1.09422651
41MP0005380_embryogenesis_phenotype1.08796577
42MP0001672_abnormal_embryogenesis/_devel1.08796577
43MP0001929_abnormal_gametogenesis1.08578785
44MP0010678_abnormal_skin_adnexa1.06911422
45MP0003984_embryonic_growth_retardation1.06894063
46MP0010094_abnormal_chromosome_stability1.06319458
47MP0002088_abnormal_embryonic_growth/wei1.06051730
48MP0002254_reproductive_system_inflammat1.04193572
49MP0010368_abnormal_lymphatic_system1.03367090
50MP0002233_abnormal_nose_morphology1.01610677
51MP0003698_abnormal_male_reproductive1.00322657
52MP0003315_abnormal_perineum_morphology0.98125839
53MP0000647_abnormal_sebaceous_gland0.97630074
54MP0000490_abnormal_crypts_of0.97123775
55MP0001915_intracranial_hemorrhage0.96863347
56MP0004233_abnormal_muscle_weight0.95937683
57MP0001286_abnormal_eye_development0.94048899
58MP0002160_abnormal_reproductive_system0.92941759
59MP0000462_abnormal_digestive_system0.92680525
60MP0001697_abnormal_embryo_size0.91451985
61MP0009379_abnormal_foot_pigmentation0.90219787
62MP0005501_abnormal_skin_physiology0.89777412
63MP0002653_abnormal_ependyma_morphology0.88733967
64MP0002837_dystrophic_cardiac_calcinosis0.87191035
65MP0001270_distended_abdomen0.86785304
66MP0002139_abnormal_hepatobiliary_system0.85140688
67MP0010329_abnormal_lipoprotein_level0.84854239
68MP0003123_paternal_imprinting0.84482879
69MP0006035_abnormal_mitochondrial_morpho0.84223494
70MP0002132_abnormal_respiratory_system0.83621155
71MP0002127_abnormal_cardiovascular_syste0.83495010
72MP0005394_taste/olfaction_phenotype0.82694801
73MP0005499_abnormal_olfactory_system0.82694801
74MP0005083_abnormal_biliary_tract0.80603300
75MP0010386_abnormal_urinary_bladder0.78689884
76MP0001324_abnormal_eye_pigmentation0.78167927
77MP0008875_abnormal_xenobiotic_pharmacok0.76656162
78MP0005551_abnormal_eye_electrophysiolog0.76565905
79MP0002085_abnormal_embryonic_tissue0.73562909
80MP0001968_abnormal_touch/_nociception0.71776711
81MP0006036_abnormal_mitochondrial_physio0.71160447
82MP0005408_hypopigmentation0.70842249
83MP0004147_increased_porphyrin_level0.70588278
84MP0002084_abnormal_developmental_patter0.70093168
85MP0005389_reproductive_system_phenotype0.69559086
86MP0001299_abnormal_eye_distance/0.69367883
87MP0004808_abnormal_hematopoietic_stem0.67156657
88MP0003755_abnormal_palate_morphology0.66965558
89MP0003136_yellow_coat_color0.66856834
90MP0002086_abnormal_extraembryonic_tissu0.65510523
91MP0001346_abnormal_lacrimal_gland0.65349628
92MP0002736_abnormal_nociception_after0.63553005
93MP0002796_impaired_skin_barrier0.63313161
94MP0002090_abnormal_vision0.62411960
95MP0003045_fibrosis0.60150721
96MP0003638_abnormal_response/metabolism_0.59981227
97MP0002295_abnormal_pulmonary_circulatio0.59822290
98MP0001919_abnormal_reproductive_system0.58906306
99MP0004197_abnormal_fetal_growth/weight/0.58818079
100MP0003938_abnormal_ear_development0.58478281

Predicted human phenotypes

RankGene SetZ-score
13-Methylglutaconic aciduria (HP:0003535)5.13245417
2Hypobetalipoproteinemia (HP:0003563)5.05354359
3Microvesicular hepatic steatosis (HP:0001414)4.49317979
4Acanthocytosis (HP:0001927)4.44309315
5Visual hallucinations (HP:0002367)4.37288215
6Type I transferrin isoform profile (HP:0003642)3.72930158
7Nonimmune hydrops fetalis (HP:0001790)3.72706918
8Hypoplasia of the pons (HP:0012110)3.66206724
9Agammaglobulinemia (HP:0004432)3.50349099
10Atonic seizures (HP:0010819)3.50324920
11Dyschromatopsia (HP:0007641)3.31164477
12Testicular atrophy (HP:0000029)3.29673371
13Hypolipoproteinemia (HP:0010981)3.28492702
14Abnormal protein glycosylation (HP:0012346)3.27646831
15Abnormal glycosylation (HP:0012345)3.27646831
16Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.27646831
17Abnormal protein N-linked glycosylation (HP:0012347)3.27646831
18Sensory axonal neuropathy (HP:0003390)3.25313630
19Absence seizures (HP:0002121)3.24796904
20Mixed hearing impairment (HP:0000410)3.16234036
21Focal motor seizures (HP:0011153)3.14072756
22Decreased muscle mass (HP:0003199)3.12953760
23Reduced antithrombin III activity (HP:0001976)3.10811117
24Abnormality of the pons (HP:0007361)3.06373295
25Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.05937278
26Abnormality of alanine metabolism (HP:0010916)3.05937278
27Hyperalaninemia (HP:0003348)3.05937278
28Dysphonia (HP:0001618)2.96340148
29Esophageal atresia (HP:0002032)2.90037736
30Poikiloderma (HP:0001029)2.70526284
31Global brain atrophy (HP:0002283)2.68987819
32Central scotoma (HP:0000603)2.66348449
33Recurrent bronchitis (HP:0002837)2.65391269
34Dyskinesia (HP:0100660)2.61239699
35Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.59602402
36Prolonged partial thromboplastin time (HP:0003645)2.54600363
37Methylmalonic acidemia (HP:0002912)2.53650267
38Progressive external ophthalmoplegia (HP:0000590)2.42889757
39Reticulocytopenia (HP:0001896)2.40329144
40Abnormality of the intrinsic pathway (HP:0010989)2.35880560
41Irregular epiphyses (HP:0010582)2.32937652
42Acute necrotizing encephalopathy (HP:0006965)2.29690835
43Scotoma (HP:0000575)2.26987410
44Mitochondrial inheritance (HP:0001427)2.26784317
45Hepatocellular necrosis (HP:0001404)2.26451815
46Abnormal auditory evoked potentials (HP:0006958)2.26447570
47Chromsome breakage (HP:0040012)2.24951152
48Decreased activity of mitochondrial respiratory chain (HP:0008972)2.24659439
49Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.24659439
50Concave nail (HP:0001598)2.21705733
51Broad distal phalanx of finger (HP:0009836)2.21508768
52Increased CSF lactate (HP:0002490)2.21105217
53Dialeptic seizures (HP:0011146)2.20274745
54Opisthotonus (HP:0002179)2.19795986
55Resting tremor (HP:0002322)2.11460212
56Chromosomal breakage induced by crosslinking agents (HP:0003221)2.11292236
57Freckling (HP:0001480)2.06996578
58Acute encephalopathy (HP:0006846)2.05327244
59Meckel diverticulum (HP:0002245)2.05187591
60Akinesia (HP:0002304)2.04651101
61Bronchitis (HP:0012387)2.01251769
62Hypergonadotropic hypogonadism (HP:0000815)1.98628605
63Nasolacrimal duct obstruction (HP:0000579)1.98168997
64Abnormality of methionine metabolism (HP:0010901)1.97751452
65Hepatic necrosis (HP:0002605)1.97591720
66Papillary thyroid carcinoma (HP:0002895)1.96942548
67Anteriorly placed anus (HP:0001545)1.95285980
68Abnormal mitochondria in muscle tissue (HP:0008316)1.95161369
69Abnormality of the ileum (HP:0001549)1.94584437
70Thrombocytosis (HP:0001894)1.90821018
71Increased hepatocellular lipid droplets (HP:0006565)1.90546939
72Abnormal ventriculo-arterial connection (HP:0011563)1.90455049
73Transposition of the great arteries (HP:0001669)1.90455049
74Abnormal connection of the cardiac segments (HP:0011545)1.90455049
75Broad nasal tip (HP:0000455)1.89802841
76Premature ovarian failure (HP:0008209)1.89349343
77Stenosis of the external auditory canal (HP:0000402)1.88701771
78Cerebral edema (HP:0002181)1.87217404
79Gliosis (HP:0002171)1.87047060
80Abnormality of the middle phalanges of the toes (HP:0010183)1.86491227
81Macrocytic anemia (HP:0001972)1.84984835
82Absent radius (HP:0003974)1.83866936
83Abnormality of the vitamin B12 metabolism (HP:0004341)1.83545432
84Hyperglycinemia (HP:0002154)1.78569618
85Gastrointestinal atresia (HP:0002589)1.78516043
86Menstrual irregularities (HP:0000858)1.77218853
87Abnormality of vitamin B metabolism (HP:0004340)1.76306101
88CNS demyelination (HP:0007305)1.74514402
89Abnormality of the fetal cardiovascular system (HP:0010948)1.71738844
90Abnormal umbilical cord blood vessels (HP:0011403)1.71738844
91Single umbilical artery (HP:0001195)1.71738844
92Rhabdomyolysis (HP:0003201)1.71441735
93Abnormality of the labia minora (HP:0012880)1.70530403
94Lipid accumulation in hepatocytes (HP:0006561)1.69836780
95Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.69824195
96Poor suck (HP:0002033)1.69652923
97Triphalangeal thumb (HP:0001199)1.67283859
98Abnormality of vitamin metabolism (HP:0100508)1.67175277
99Abnormality of the preputium (HP:0100587)1.66643549
100Carpal bone hypoplasia (HP:0001498)1.66532890

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK4.01623591
2MUSK3.50826660
3CDC73.48646003
4VRK23.34789443
5LATS13.34366676
6BRD43.22678260
7SCYL23.03612186
8MAP3K122.52745983
9NUAK12.46475123
10NME22.44972041
11MKNK12.15967922
12NEK22.15089857
13SMG12.11485202
14KDR1.94783731
15WNK31.91280777
16TAF11.84656007
17SRPK11.68254512
18STK31.64686154
19PRKD31.64195732
20MAP2K11.63168233
21BLK1.56111277
22ACVR1B1.52455759
23PNCK1.39268849
24TRIM281.37973174
25MST1R1.33883907
26MYLK1.32785527
27CASK1.30917770
28PKN21.30892655
29MAP2K31.30022799
30NEK11.29947324
31MAP3K41.28814885
32MST41.27708758
33CDK71.24577161
34ERBB31.20647773
35PLK41.20146519
36RPS6KB11.17757447
37FGFR11.13469888
38PASK1.05555725
39MAP3K80.97216614
40MKNK20.92785939
41CDK120.92215733
42MELK0.92017191
43FLT30.89656851
44MAP3K100.89501578
45CDK190.88629076
46MATK0.81699791
47LYN0.81566646
48ICK0.80291898
49BRSK20.75143572
50ALK0.75017282
51PIK3CA0.74975807
52MAP3K50.74661108
53SIK30.74458084
54CSNK2A10.72952328
55PRKG20.69466442
56MAP3K90.67913758
57AURKA0.67198490
58IKBKE0.65673987
59CSNK2A20.64978403
60EGFR0.64323645
61DYRK1B0.62845303
62DYRK20.62367381
63RPS6KA40.61727008
64CHEK10.60676137
65ADRBK10.58885721
66STK240.58026902
67STK160.57632933
68ERBB40.55217808
69MAP3K30.54056472
70BRSK10.53162520
71MAP2K70.52974181
72MAP2K40.52317515
73BMPR1B0.52219371
74PINK10.51591570
75PLK10.50031873
76CHEK20.49103915
77SYK0.46808892
78STK40.44931231
79RPS6KB20.43947358
80PAK20.43346206
81PRKG10.42978884
82ABL20.40285349
83DAPK30.39721176
84PDPK10.39532925
85VRK10.37444818
86PAK40.36707877
87NEK60.36594640
88FGFR20.35998281
89FYN0.35913654
90PRKCQ0.34106342
91AURKB0.33899535
92CSNK1D0.31174288
93ATR0.30671589
94MAPKAPK50.30631030
95PRPF4B0.30094966
96TGFBR10.28321719
97EPHA20.28079538
98TRPM70.26809823
99CDK20.24598594
100MAPK30.23446246

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.14546970
2Proteasome_Homo sapiens_hsa030504.34413201
3Pantothenate and CoA biosynthesis_Homo sapiens_hsa007703.64535800
4Oxidative phosphorylation_Homo sapiens_hsa001902.97575599
5Protein export_Homo sapiens_hsa030602.89380124
6Parkinsons disease_Homo sapiens_hsa050122.64534074
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.38509528
8Huntingtons disease_Homo sapiens_hsa050162.32991402
9Mismatch repair_Homo sapiens_hsa034302.07666266
10One carbon pool by folate_Homo sapiens_hsa006702.02918312
11RNA transport_Homo sapiens_hsa030132.00427398
12Fanconi anemia pathway_Homo sapiens_hsa034601.89856936
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.70981624
14Alzheimers disease_Homo sapiens_hsa050101.69505183
15Cysteine and methionine metabolism_Homo sapiens_hsa002701.64850495
16Selenocompound metabolism_Homo sapiens_hsa004501.61727070
17RNA polymerase_Homo sapiens_hsa030201.61324507
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.60040858
19Homologous recombination_Homo sapiens_hsa034401.58831800
20Sulfur relay system_Homo sapiens_hsa041221.54136087
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.48717848
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.47542935
23DNA replication_Homo sapiens_hsa030301.46038865
24Nitrogen metabolism_Homo sapiens_hsa009101.45558240
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43212448
26Dorso-ventral axis formation_Homo sapiens_hsa043201.40947548
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39194269
28TGF-beta signaling pathway_Homo sapiens_hsa043501.38232842
29Non-homologous end-joining_Homo sapiens_hsa034501.34103702
30SNARE interactions in vesicular transport_Homo sapiens_hsa041301.33646104
31Pyrimidine metabolism_Homo sapiens_hsa002401.32269118
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.31264251
33Spliceosome_Homo sapiens_hsa030401.25843316
34N-Glycan biosynthesis_Homo sapiens_hsa005101.19193496
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.15831604
36Pyruvate metabolism_Homo sapiens_hsa006201.15533417
37Sphingolipid metabolism_Homo sapiens_hsa006001.14313302
38Basal transcription factors_Homo sapiens_hsa030221.14195805
39Retinol metabolism_Homo sapiens_hsa008301.11322100
40Base excision repair_Homo sapiens_hsa034101.09717037
41Glutathione metabolism_Homo sapiens_hsa004801.03038257
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.98963497
43Nucleotide excision repair_Homo sapiens_hsa034200.97835285
44RNA degradation_Homo sapiens_hsa030180.96585545
45Phototransduction_Homo sapiens_hsa047440.95206500
46Chemical carcinogenesis_Homo sapiens_hsa052040.92514792
47Vitamin B6 metabolism_Homo sapiens_hsa007500.90964939
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89991479
49Sulfur metabolism_Homo sapiens_hsa009200.88663590
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88317694
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.87221608
52Cardiac muscle contraction_Homo sapiens_hsa042600.86290617
53mRNA surveillance pathway_Homo sapiens_hsa030150.82270100
54Folate biosynthesis_Homo sapiens_hsa007900.78642498
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78353824
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78315144
57beta-Alanine metabolism_Homo sapiens_hsa004100.78225180
58Fat digestion and absorption_Homo sapiens_hsa049750.77657710
59Nicotine addiction_Homo sapiens_hsa050330.75864056
60B cell receptor signaling pathway_Homo sapiens_hsa046620.75159045
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.72157414
62Primary immunodeficiency_Homo sapiens_hsa053400.68513554
63Purine metabolism_Homo sapiens_hsa002300.68353770
64Metabolic pathways_Homo sapiens_hsa011000.66967176
65Serotonergic synapse_Homo sapiens_hsa047260.66142694
66Tryptophan metabolism_Homo sapiens_hsa003800.65902288
67Intestinal immune network for IgA production_Homo sapiens_hsa046720.65620267
68Propanoate metabolism_Homo sapiens_hsa006400.64421240
69Cell cycle_Homo sapiens_hsa041100.62498555
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61187476
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58584193
72Wnt signaling pathway_Homo sapiens_hsa043100.54754837
73Galactose metabolism_Homo sapiens_hsa000520.54222948
74Phenylalanine metabolism_Homo sapiens_hsa003600.54213467
75Hematopoietic cell lineage_Homo sapiens_hsa046400.53779039
76Hippo signaling pathway_Homo sapiens_hsa043900.53718334
77Biosynthesis of amino acids_Homo sapiens_hsa012300.52059856
78Vitamin digestion and absorption_Homo sapiens_hsa049770.50762190
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50195571
80p53 signaling pathway_Homo sapiens_hsa041150.48043364
81Peroxisome_Homo sapiens_hsa041460.45463339
82Asthma_Homo sapiens_hsa053100.44154953
83Caffeine metabolism_Homo sapiens_hsa002320.40509798
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.39808841
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36295218
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.35489717
87Colorectal cancer_Homo sapiens_hsa052100.34135762
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33192741
89Thyroid cancer_Homo sapiens_hsa052160.30818770
90Adherens junction_Homo sapiens_hsa045200.28957421
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28544545
92Fatty acid elongation_Homo sapiens_hsa000620.28022356
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.27076318
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26478437
95Tyrosine metabolism_Homo sapiens_hsa003500.25972052
96Taste transduction_Homo sapiens_hsa047420.25462756
97Basal cell carcinoma_Homo sapiens_hsa052170.24517268
98Other glycan degradation_Homo sapiens_hsa005110.23159398
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22182516
100Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.20305800

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