SNX27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mouse is responsible for the specific recruitment of an isoform of serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane organization (GO:0097090)7.62559894
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.82347466
3presynaptic membrane assembly (GO:0097105)6.14901953
4synaptic vesicle maturation (GO:0016188)5.39483849
5ionotropic glutamate receptor signaling pathway (GO:0035235)5.27315973
6locomotory exploration behavior (GO:0035641)5.13117179
7layer formation in cerebral cortex (GO:0021819)5.03168552
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.01262633
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.81932790
10pyrimidine nucleobase catabolic process (GO:0006208)4.72285834
11vocalization behavior (GO:0071625)4.67091897
12glutamate secretion (GO:0014047)4.65952661
13synaptic vesicle exocytosis (GO:0016079)4.61624369
14negative regulation of translation, ncRNA-mediated (GO:0040033)4.52914620
15regulation of translation, ncRNA-mediated (GO:0045974)4.52914620
16negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.52914620
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.49865232
18synaptic transmission, glutamatergic (GO:0035249)4.41441018
19neuron cell-cell adhesion (GO:0007158)4.33345350
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.31619080
21regulation of synaptic vesicle exocytosis (GO:2000300)4.29788460
22glutamate receptor signaling pathway (GO:0007215)4.28008164
23regulation of glutamate receptor signaling pathway (GO:1900449)4.21146353
24regulation of neuronal synaptic plasticity (GO:0048168)4.07624498
25neuron-neuron synaptic transmission (GO:0007270)4.06224445
26regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.02445888
27exploration behavior (GO:0035640)4.00796556
28neurotransmitter secretion (GO:0007269)4.00315807
29water-soluble vitamin biosynthetic process (GO:0042364)3.97799719
30regulation of synapse structural plasticity (GO:0051823)3.94904709
31protein localization to synapse (GO:0035418)3.94801449
32neuron recognition (GO:0008038)3.93323634
33prepulse inhibition (GO:0060134)3.86261599
34dendritic spine morphogenesis (GO:0060997)3.86175022
35negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.84226884
36protein K6-linked ubiquitination (GO:0085020)3.83548244
37neuronal action potential propagation (GO:0019227)3.78854173
38nucleobase catabolic process (GO:0046113)3.77705891
39regulation of synaptic vesicle transport (GO:1902803)3.77279499
40gamma-aminobutyric acid transport (GO:0015812)3.76545988
41negative regulation of synaptic transmission, GABAergic (GO:0032229)3.72867691
42L-amino acid import (GO:0043092)3.72056296
43transmission of nerve impulse (GO:0019226)3.69012890
44postsynaptic membrane organization (GO:0001941)3.68143510
45cellular potassium ion homeostasis (GO:0030007)3.65346333
46regulation of excitatory postsynaptic membrane potential (GO:0060079)3.58935251
47synaptic vesicle docking involved in exocytosis (GO:0016081)3.56386086
48dendrite morphogenesis (GO:0048813)3.55009269
49neuromuscular process controlling balance (GO:0050885)3.52465094
50neurotransmitter-gated ion channel clustering (GO:0072578)3.51667217
51cerebellar granule cell differentiation (GO:0021707)3.44600377
52monoubiquitinated protein deubiquitination (GO:0035520)3.43612210
53sodium ion export (GO:0071436)3.42147813
54proline transport (GO:0015824)3.41885762
55regulation of postsynaptic membrane potential (GO:0060078)3.41113722
56positive regulation of synapse assembly (GO:0051965)3.37342552
57regulation of dendritic spine morphogenesis (GO:0061001)3.37174100
58positive regulation of synapse maturation (GO:0090129)3.36030189
59axonal fasciculation (GO:0007413)3.34376013
60neurotransmitter transport (GO:0006836)3.33174477
61membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.32069860
62cell migration in hindbrain (GO:0021535)3.29346845
63behavioral fear response (GO:0001662)3.28441797
64behavioral defense response (GO:0002209)3.28441797
65neuronal ion channel clustering (GO:0045161)3.26887295
66gamma-aminobutyric acid signaling pathway (GO:0007214)3.25176201
67olfactory bulb development (GO:0021772)3.24792924
68amino acid import (GO:0043090)3.24457134
69long-term memory (GO:0007616)3.22209977
70regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.19881906
71vesicle transport along microtubule (GO:0047496)3.19627587
72synaptic vesicle endocytosis (GO:0048488)3.17872441
73positive regulation of dendrite morphogenesis (GO:0050775)3.17177918
74DNA double-strand break processing (GO:0000729)3.16734899
75regulation of synaptic transmission, glutamatergic (GO:0051966)3.15367841
76membrane hyperpolarization (GO:0060081)3.14003810
77activation of protein kinase A activity (GO:0034199)3.13532358
78regulation of synaptic plasticity (GO:0048167)3.12416656
79mating behavior (GO:0007617)3.12325966
80G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.11833051
81positive regulation of membrane potential (GO:0045838)3.10867498
82serotonin metabolic process (GO:0042428)3.08346137
83membrane assembly (GO:0071709)3.07533312
84response to auditory stimulus (GO:0010996)3.06261870
85auditory behavior (GO:0031223)3.04907537
86regulation of neurotransmitter levels (GO:0001505)3.03698794
87positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.03565976
88glycine transport (GO:0015816)3.02958104
89positive regulation of synaptic transmission, GABAergic (GO:0032230)3.01440186
90regulation of telomere maintenance via telomerase (GO:0032210)3.01370235
91central nervous system projection neuron axonogenesis (GO:0021952)3.00217098
92positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.99848355
93cerebellar Purkinje cell differentiation (GO:0021702)2.99406688
94G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.98591149
95adult walking behavior (GO:0007628)2.98546219
96C4-dicarboxylate transport (GO:0015740)2.98383917
97striatum development (GO:0021756)2.97280402
98fear response (GO:0042596)2.97104204
99organelle transport along microtubule (GO:0072384)2.96756553
100positive regulation of dendrite development (GO:1900006)2.94961053
101adaptation of signaling pathway (GO:0023058)2.94826268
102replication fork processing (GO:0031297)2.92956137
103dopamine receptor signaling pathway (GO:0007212)2.92754779
104histone H3-K9 demethylation (GO:0033169)2.92271611
105histone H3-K36 demethylation (GO:0070544)2.90118582
106clathrin coat assembly (GO:0048268)2.89589490
107mechanosensory behavior (GO:0007638)2.89395269
108positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.89069291
109nonmotile primary cilium assembly (GO:0035058)2.88400588
110regulation of dendritic spine development (GO:0060998)2.85333309
111neuromuscular process (GO:0050905)2.85006156
112regulation of synaptic transmission, GABAergic (GO:0032228)2.84577496
113behavioral response to nicotine (GO:0035095)2.83790404
114synapse assembly (GO:0007416)2.81594453
115membrane depolarization (GO:0051899)2.81575617
116regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.80705090
117regulation of dendrite morphogenesis (GO:0048814)2.79248248
118synapse organization (GO:0050808)2.79147295
119protein K11-linked deubiquitination (GO:0035871)2.79051682
120regulation of neurotransmitter secretion (GO:0046928)2.78544202
121regulation of collateral sprouting (GO:0048670)2.78413483
122adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.78255959
123retinal cone cell development (GO:0046549)2.76305358
124negative regulation of DNA-dependent DNA replication (GO:2000104)2.74779627
125prenylation (GO:0097354)2.72826515
126protein prenylation (GO:0018342)2.72826515
127startle response (GO:0001964)2.70255652
128protein polyglutamylation (GO:0018095)2.69991584
129regulation of neurotransmitter uptake (GO:0051580)2.69388476
130neural tube formation (GO:0001841)2.68273740
131positive regulation of oligodendrocyte differentiation (GO:0048714)2.67173843
132negative regulation of DNA recombination (GO:0045910)2.65486574
133negative regulation of membrane potential (GO:0045837)2.63125758
134negative regulation of dendrite development (GO:2000171)2.62821828
135primary amino compound metabolic process (GO:1901160)2.62271998
136inositol phosphate catabolic process (GO:0071545)2.61359194
137negative regulation of systemic arterial blood pressure (GO:0003085)2.61310768
138limb bud formation (GO:0060174)2.59578701
139prostate gland growth (GO:0060736)2.56004971
140reflex (GO:0060004)2.54369442
141L-fucose catabolic process (GO:0042355)2.53349554
142fucose catabolic process (GO:0019317)2.53349554
143L-fucose metabolic process (GO:0042354)2.53349554
144glycosphingolipid biosynthetic process (GO:0006688)2.51798482
145kidney morphogenesis (GO:0060993)2.51648470
146resolution of meiotic recombination intermediates (GO:0000712)2.50669986
147negative regulation of transcription regulatory region DNA binding (GO:2000678)2.49188207
148regulation of timing of cell differentiation (GO:0048505)2.47966334
149protein complex biogenesis (GO:0070271)2.47838241
150cytochrome complex assembly (GO:0017004)2.47461002
151neurotransmitter uptake (GO:0001504)2.46199219
152cell wall macromolecule catabolic process (GO:0016998)2.42367387
153platelet dense granule organization (GO:0060155)2.41608381
154response to pheromone (GO:0019236)2.39977992
155cell wall macromolecule metabolic process (GO:0044036)2.39896327
156protein localization to cilium (GO:0061512)2.38999099
157respiratory chain complex IV assembly (GO:0008535)2.36629515
158glial cell proliferation (GO:0014009)2.34707262
159sympathetic nervous system development (GO:0048485)2.33201643
160brain morphogenesis (GO:0048854)2.32987346
161positive regulation of mRNA processing (GO:0050685)2.32871010
162mitochondrial respiratory chain complex assembly (GO:0033108)2.32770545
163RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.30460808
164anterograde axon cargo transport (GO:0008089)2.30450351
165somatic diversification of immune receptors via somatic mutation (GO:0002566)2.29743779
166somatic hypermutation of immunoglobulin genes (GO:0016446)2.29743779
167detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.29107627
168negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.27518529
169regulation of development, heterochronic (GO:0040034)2.26212898
170limb development (GO:0060173)2.26009756
171appendage development (GO:0048736)2.26009756
172anterograde synaptic vesicle transport (GO:0048490)2.25977128
173central nervous system neuron axonogenesis (GO:0021955)2.23914542
174righting reflex (GO:0060013)2.23483774
175sulfation (GO:0051923)2.23044219

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.78881283
2GBX2_23144817_ChIP-Seq_PC3_Human3.61436116
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.88522359
4RARB_27405468_Chip-Seq_BRAIN_Mouse2.77628477
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.74354160
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.73234947
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.67939093
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.65733371
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.61298723
10REST_21632747_ChIP-Seq_MESCs_Mouse2.60196285
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.50581479
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.50581479
13DROSHA_22980978_ChIP-Seq_HELA_Human2.43805805
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.26835954
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25293562
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.25008036
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.20709745
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.18250673
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.17173788
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.16630252
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.15279695
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.15154526
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.13806462
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.07757836
25EWS_26573619_Chip-Seq_HEK293_Human2.04877608
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.04195958
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.99028812
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.98386762
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95589510
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.93754468
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.93424468
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.88396502
33ER_23166858_ChIP-Seq_MCF-7_Human1.86403567
34VDR_22108803_ChIP-Seq_LS180_Human1.84497488
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79129541
36* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74510358
37AR_21572438_ChIP-Seq_LNCaP_Human1.69863572
38TAF15_26573619_Chip-Seq_HEK293_Human1.68823859
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68348130
40MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.67140427
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.66930480
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.66450962
43* SMAD4_21799915_ChIP-Seq_A2780_Human1.65354646
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63273049
45TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.56415208
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.55233139
47CBP_20019798_ChIP-Seq_JUKART_Human1.52671720
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52671720
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52160814
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.52152728
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.48691574
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43233154
53BCAT_22108803_ChIP-Seq_LS180_Human1.42723927
54TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41412963
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.41368523
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40212542
57NANOG_18555785_Chip-Seq_ESCs_Mouse1.39756098
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.38926784
59HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38693011
60SOX2_21211035_ChIP-Seq_LN229_Gbm1.38588066
61ZNF274_21170338_ChIP-Seq_K562_Hela1.38242987
62ARNT_22903824_ChIP-Seq_MCF-7_Human1.38049273
63STAT3_23295773_ChIP-Seq_U87_Human1.37763884
64IRF1_19129219_ChIP-ChIP_H3396_Human1.37454533
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36447660
66ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36355464
67* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36213612
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36155658
69POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35770566
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34010870
71WT1_25993318_ChIP-Seq_PODOCYTE_Human1.32875311
72AR_19668381_ChIP-Seq_PC3_Human1.32858923
73RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.32323483
74RING1B_27294783_Chip-Seq_ESCs_Mouse1.29949627
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28851966
76KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.28467938
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.28386967
78YAP1_20516196_ChIP-Seq_MESCs_Mouse1.27859292
79P300_19829295_ChIP-Seq_ESCs_Human1.27599276
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26861845
81P53_22387025_ChIP-Seq_ESCs_Mouse1.24200106
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.23596043
83ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22890676
84RING1B_27294783_Chip-Seq_NPCs_Mouse1.22586893
85KDM2B_26808549_Chip-Seq_K562_Human1.21948294
86ZFP281_27345836_Chip-Seq_ESCs_Mouse1.21177790
87TCF4_23295773_ChIP-Seq_U87_Human1.21008270
88RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20262287
89ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19721530
90FLI1_21867929_ChIP-Seq_TH2_Mouse1.19510243
91TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18678632
92E2F1_18555785_Chip-Seq_ESCs_Mouse1.18629354
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18405793
94BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.18398511
95AHR_22903824_ChIP-Seq_MCF-7_Human1.17950745
96TCF4_22108803_ChIP-Seq_LS180_Human1.17812769
97FUS_26573619_Chip-Seq_HEK293_Human1.17332397
98CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17082092
99SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.16750192
100NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16637249
101E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.16096297
102TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15900549
103CMYC_18555785_Chip-Seq_ESCs_Mouse1.15777039
104IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14853733
105AR_25329375_ChIP-Seq_VCAP_Human1.13606301
106TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12936848
107KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12829631
108PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.11803241
109NANOG_19829295_ChIP-Seq_ESCs_Human1.11498998
110SOX2_19829295_ChIP-Seq_ESCs_Human1.11498998
111* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10288118
112P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10049607
113SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09593433
114DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09131906
115KDM2B_26808549_Chip-Seq_REH_Human1.08731736
116SMAD3_21741376_ChIP-Seq_ESCs_Human1.08337597
117SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07963937
118TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07419198
119P300_18555785_Chip-Seq_ESCs_Mouse1.07282576
120TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06520178
121SMAD4_21741376_ChIP-Seq_EPCs_Human1.05983248
122CRX_20693478_ChIP-Seq_RETINA_Mouse1.05813272
123KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05281468
124JUN_21703547_ChIP-Seq_K562_Human1.05107726
125EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04989794
126ELK1_19687146_ChIP-ChIP_HELA_Human1.04508463
127TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03953064
128IGF1R_20145208_ChIP-Seq_DFB_Human1.03586811
129GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03406581
130SALL1_21062744_ChIP-ChIP_HESCs_Human1.03231062
131TAL1_26923725_Chip-Seq_HPCs_Mouse1.01934172
132RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01243093
133RNF2_27304074_Chip-Seq_NSC_Mouse1.01076856
134GABP_17652178_ChIP-ChIP_JURKAT_Human1.00920918
135STAT3_18555785_Chip-Seq_ESCs_Mouse1.00624368
136CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00528672
137DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.00345365
138RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99229902
139GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99092812
140TP53_16413492_ChIP-PET_HCT116_Human0.98872825
141NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97888925
142NOTCH1_21737748_ChIP-Seq_TLL_Human0.97694249
143CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96787075
144UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96441044
145* TBX3_20139965_ChIP-Seq_MESCs_Mouse0.96267262
146RUNX2_22187159_ChIP-Seq_PCA_Human0.96214738
147CBX2_27304074_Chip-Seq_ESCs_Mouse0.94899636
148MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94067963
149POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93727196
150TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93727196
151CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93593094
152ISL1_27105846_Chip-Seq_CPCs_Mouse0.93491539
153SMAD_19615063_ChIP-ChIP_OVARY_Human0.93370836
154SMAD4_21741376_ChIP-Seq_HESCs_Human0.92617455
155PRDM14_20953172_ChIP-Seq_ESCs_Human0.92047974

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.14552276
2MP0003880_abnormal_central_pattern4.32236258
3MP0003635_abnormal_synaptic_transmissio4.03402387
4MP0004270_analgesia3.43513231
5MP0009745_abnormal_behavioral_response3.24708144
6MP0002063_abnormal_learning/memory/cond3.18993874
7MP0002064_seizures3.10521740
8MP0009046_muscle_twitch3.06223720
9MP0003646_muscle_fatigue2.94307110
10MP0002572_abnormal_emotion/affect_behav2.60506141
11MP0002102_abnormal_ear_morphology2.46394272
12MP0005423_abnormal_somatic_nervous2.43912403
13MP0001486_abnormal_startle_reflex2.40898580
14MP0001440_abnormal_grooming_behavior2.34532824
15MP0002272_abnormal_nervous_system2.27699779
16MP0000778_abnormal_nervous_system2.21321468
17MP0003303_peritoneal_inflammation2.20730661
18MP0002822_catalepsy2.17473771
19MP0002734_abnormal_mechanical_nocicepti2.15307375
20MP0001968_abnormal_touch/_nociception2.13614088
21MP0000569_abnormal_digit_pigmentation2.12393418
22MP0002733_abnormal_thermal_nociception2.04987748
23MP0003329_amyloid_beta_deposits2.02835875
24MP0000372_irregular_coat_pigmentation1.96601440
25MP0003195_calcinosis1.90966211
26MP0002837_dystrophic_cardiac_calcinosis1.89749944
27MP0002067_abnormal_sensory_capabilities1.89709810
28MP0004885_abnormal_endolymph1.88971042
29MP0008569_lethality_at_weaning1.85783323
30MP0005174_abnormal_tail_pigmentation1.83550073
31MP0004811_abnormal_neuron_physiology1.83395490
32MP0002735_abnormal_chemical_nociception1.82416233
33MP0001970_abnormal_pain_threshold1.77228197
34MP0005171_absent_coat_pigmentation1.76561467
35MP0000955_abnormal_spinal_cord1.76542134
36MP0001501_abnormal_sleep_pattern1.76300609
37MP0005248_abnormal_Harderian_gland1.73774219
38MP0002184_abnormal_innervation1.71507398
39MP0001188_hyperpigmentation1.69933467
40MP0002557_abnormal_social/conspecific_i1.67977030
41MP0005386_behavior/neurological_phenoty1.67405481
42MP0004924_abnormal_behavior1.67405481
43MP0003136_yellow_coat_color1.65795962
44MP0008058_abnormal_DNA_repair1.62292731
45MP0004858_abnormal_nervous_system1.60828721
46MP0002909_abnormal_adrenal_gland1.53372883
47MP0005253_abnormal_eye_physiology1.52973825
48MP0009780_abnormal_chondrocyte_physiolo1.47611125
49MP0002751_abnormal_autonomic_nervous1.45216715
50MP0002066_abnormal_motor_capabilities/c1.44398181
51MP0002882_abnormal_neuron_morphology1.43803167
52MP0002736_abnormal_nociception_after1.42852059
53MP0002938_white_spotting1.42232410
54MP0000516_abnormal_urinary_system1.41147245
55MP0005367_renal/urinary_system_phenotyp1.41147245
56MP0002638_abnormal_pupillary_reflex1.38601119
57MP0002152_abnormal_brain_morphology1.38239275
58MP0004133_heterotaxia1.37493092
59MP0003633_abnormal_nervous_system1.36865294
60MP0000920_abnormal_myelination1.33678084
61MP0004130_abnormal_muscle_cell1.33473961
62MP0003690_abnormal_glial_cell1.31262028
63MP0003122_maternal_imprinting1.29489017
64MP0003787_abnormal_imprinting1.23000062
65MP0003631_nervous_system_phenotype1.22151442
66MP0003634_abnormal_glial_cell1.18074580
67MP0005187_abnormal_penis_morphology1.15838991
68MP0003632_abnormal_nervous_system1.14503490
69MP0008057_abnormal_DNA_replication1.10986089
70MP0004142_abnormal_muscle_tone1.10830644
71MP0003011_delayed_dark_adaptation1.09563386
72MP0005075_abnormal_melanosome_morpholog1.07039363
73MP0001529_abnormal_vocalization1.06708716
74MP0006276_abnormal_autonomic_nervous1.05406710
75MP0000427_abnormal_hair_cycle1.05392247
76MP0002095_abnormal_skin_pigmentation1.05074635
77MP0001986_abnormal_taste_sensitivity1.04974362
78MP0004742_abnormal_vestibular_system1.04829506
79MP0002229_neurodegeneration0.99968977
80MP0000747_muscle_weakness0.98891952
81MP0002277_abnormal_respiratory_mucosa0.98651888
82MP0003861_abnormal_nervous_system0.98366326
83MP0003172_abnormal_lysosome_physiology0.97989397
84MP0003937_abnormal_limbs/digits/tail_de0.96832496
85MP0004233_abnormal_muscle_weight0.96029440
86MP0000604_amyloidosis0.95979743
87MP0006072_abnormal_retinal_apoptosis0.93219761
88MP0005646_abnormal_pituitary_gland0.93001800
89MP0004145_abnormal_muscle_electrophysio0.91759232
90MP0001324_abnormal_eye_pigmentation0.91465804
91MP0001177_atelectasis0.91173930
92MP0003567_abnormal_fetal_cardiomyocyte0.90670257
93MP0005623_abnormal_meninges_morphology0.89540873
94MP0001299_abnormal_eye_distance/0.89272586
95MP0005408_hypopigmentation0.89136639
96MP0001502_abnormal_circadian_rhythm0.88385997
97MP0000647_abnormal_sebaceous_gland0.88182128
98MP0005394_taste/olfaction_phenotype0.87760076
99MP0005499_abnormal_olfactory_system0.87760076
100MP0002069_abnormal_eating/drinking_beha0.87589856
101MP0006292_abnormal_olfactory_placode0.86779377
102MP0002928_abnormal_bile_duct0.86189472
103MP0004381_abnormal_hair_follicle0.83366125
104MP0001984_abnormal_olfaction0.83237029
105MP0003718_maternal_effect0.82282688
106MP0010094_abnormal_chromosome_stability0.81434768
107MP0008789_abnormal_olfactory_epithelium0.80852616
108MP0008872_abnormal_physiological_respon0.78409456
109MP0000631_abnormal_neuroendocrine_gland0.77723981
110MP0003724_increased_susceptibility_to0.77291865
111MP0003119_abnormal_digestive_system0.77078728
112MP0003123_paternal_imprinting0.76784491
113MP0000026_abnormal_inner_ear0.76359120
114MP0000015_abnormal_ear_pigmentation0.74342347
115MP0008961_abnormal_basal_metabolism0.73884303
116MP0002752_abnormal_somatic_nervous0.73871017
117MP0002653_abnormal_ependyma_morphology0.73639507
118MP0001905_abnormal_dopamine_level0.71024311
119MP0003879_abnormal_hair_cell0.70982542
120MP0003121_genomic_imprinting0.70089438
121MP0010769_abnormal_survival0.68381395
122MP0010770_preweaning_lethality0.67978998
123MP0002082_postnatal_lethality0.67978998
124MP0005551_abnormal_eye_electrophysiolog0.67173044
125MP0003385_abnormal_body_wall0.66930610
126MP0008877_abnormal_DNA_methylation0.65850239
127MP0001485_abnormal_pinna_reflex0.65021868
128MP0005409_darkened_coat_color0.64846617
129MP0010768_mortality/aging0.64716592
130MP0008874_decreased_physiological_sensi0.64256386
131MP0002090_abnormal_vision0.63735270
132MP0003890_abnormal_embryonic-extraembry0.61622174
133MP0005535_abnormal_body_temperature0.61543577
134MP0001943_abnormal_respiration0.60584471
135MP0009379_abnormal_foot_pigmentation0.60262252
136MP0001963_abnormal_hearing_physiology0.59169027
137MP0004043_abnormal_pH_regulation0.58658386

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.78216786
2Myokymia (HP:0002411)4.73799751
3Focal seizures (HP:0007359)4.44349667
4Ankle clonus (HP:0011448)3.90535033
5Visual hallucinations (HP:0002367)3.85077807
6Supranuclear gaze palsy (HP:0000605)3.57726653
7Cutaneous melanoma (HP:0012056)3.49130039
8Scanning speech (HP:0002168)3.46223399
9Absent speech (HP:0001344)3.42515826
10Progressive cerebellar ataxia (HP:0002073)3.32565714
11Epileptic encephalopathy (HP:0200134)3.27705666
12Retinal atrophy (HP:0001105)3.27132991
13Urinary bladder sphincter dysfunction (HP:0002839)3.19481859
14Buphthalmos (HP:0000557)3.14555812
15Type II lissencephaly (HP:0007260)3.13413908
16Methylmalonic acidemia (HP:0002912)3.06042987
17Neoplasm of the adrenal cortex (HP:0100641)3.04513602
18Methylmalonic aciduria (HP:0012120)3.04133111
19Termporal pattern (HP:0011008)3.02521214
20Insidious onset (HP:0003587)3.02521214
21Retinal dysplasia (HP:0007973)3.02018282
22Cerebral inclusion bodies (HP:0100314)2.98038844
23Hepatoblastoma (HP:0002884)2.97714313
24Abnormality of the labia minora (HP:0012880)2.93649439
25Impaired vibration sensation in the lower limbs (HP:0002166)2.93241491
26Neurofibrillary tangles (HP:0002185)2.92199929
27Urinary urgency (HP:0000012)2.91756923
28Action tremor (HP:0002345)2.91508311
29Abnormality of the astrocytes (HP:0100707)2.90047970
30Astrocytoma (HP:0009592)2.90047970
31Spastic gait (HP:0002064)2.89561478
32Postural instability (HP:0002172)2.84963286
33Dialeptic seizures (HP:0011146)2.84876233
34Pancreatic cysts (HP:0001737)2.80952717
35Neoplasm of the adrenal gland (HP:0100631)2.80411348
36Absence seizures (HP:0002121)2.73990567
37Genetic anticipation (HP:0003743)2.72856294
38Meningioma (HP:0002858)2.71966372
39Cerebellar dysplasia (HP:0007033)2.71593394
40Generalized tonic-clonic seizures (HP:0002069)2.71328669
41Inability to walk (HP:0002540)2.70120996
42Abnormality of the corticospinal tract (HP:0002492)2.66263829
43Spastic tetraparesis (HP:0001285)2.64917269
44Atonic seizures (HP:0010819)2.63760657
45Hypothermia (HP:0002045)2.63132406
46Drooling (HP:0002307)2.62907784
47Excessive salivation (HP:0003781)2.62907784
48Febrile seizures (HP:0002373)2.62764861
49Broad-based gait (HP:0002136)2.62168529
50Mutism (HP:0002300)2.62144236
51Truncal ataxia (HP:0002078)2.60026835
52Abnormal eating behavior (HP:0100738)2.59564936
53Dysdiadochokinesis (HP:0002075)2.57476526
54Medial flaring of the eyebrow (HP:0010747)2.56761809
55Ependymoma (HP:0002888)2.55241656
56Megalencephaly (HP:0001355)2.53938725
57Dysmetria (HP:0001310)2.52621813
58Gaze-evoked nystagmus (HP:0000640)2.51059267
59Subacute progressive viral hepatitis (HP:0006572)2.50952224
60Depression (HP:0000716)2.50539032
61Pancreatic fibrosis (HP:0100732)2.49808322
62True hermaphroditism (HP:0010459)2.49272313
63Intention tremor (HP:0002080)2.47561309
64Tented upper lip vermilion (HP:0010804)2.47102503
65Anterior segment dysgenesis (HP:0007700)2.46234945
66Gait imbalance (HP:0002141)2.45885770
67Neuronal loss in central nervous system (HP:0002529)2.44887964
68Papilledema (HP:0001085)2.43811426
69Stomach cancer (HP:0012126)2.42710599
70Dysmetric saccades (HP:0000641)2.41037475
71Amyotrophic lateral sclerosis (HP:0007354)2.40919544
72Poor eye contact (HP:0000817)2.40604796
73Abnormal social behavior (HP:0012433)2.39566741
74Impaired social interactions (HP:0000735)2.39566741
75Lower limb muscle weakness (HP:0007340)2.39055266
76Abnormality of the lower motor neuron (HP:0002366)2.38595168
77Agnosia (HP:0010524)2.38484113
78Bradykinesia (HP:0002067)2.34008437
79Genital tract atresia (HP:0001827)2.33374700
80Abolished electroretinogram (ERG) (HP:0000550)2.29956173
81Congenital primary aphakia (HP:0007707)2.27468286
82Insomnia (HP:0100785)2.25841446
83Vaginal atresia (HP:0000148)2.25012633
84Clonus (HP:0002169)2.22640228
85Volvulus (HP:0002580)2.21939861
86Glioma (HP:0009733)2.20486994
87Impaired smooth pursuit (HP:0007772)2.20079031
88Hyperglycinemia (HP:0002154)2.19683919
89Hemiparesis (HP:0001269)2.19387652
90Nephrogenic diabetes insipidus (HP:0009806)2.18353919
91Abnormality of binocular vision (HP:0011514)2.17172427
92Diplopia (HP:0000651)2.17172427
93Molar tooth sign on MRI (HP:0002419)2.13834925
94Abnormality of midbrain morphology (HP:0002418)2.13834925
95Aplasia/Hypoplasia of the brainstem (HP:0007362)2.12944813
96Hypoplasia of the brainstem (HP:0002365)2.12944813
97Pointed chin (HP:0000307)2.12374894
98Progressive inability to walk (HP:0002505)2.10555601
99Colon cancer (HP:0003003)2.10549991
100Intellectual disability, profound (HP:0002187)2.07890104
101Intellectual disability, moderate (HP:0002342)2.07264837
102Congenital sensorineural hearing impairment (HP:0008527)2.06616599
103Impaired vibratory sensation (HP:0002495)2.03543329
104Nephronophthisis (HP:0000090)2.02660282
105Abnormality of ocular smooth pursuit (HP:0000617)2.02611944
106Megalocornea (HP:0000485)2.02365868
107Attenuation of retinal blood vessels (HP:0007843)2.01596064
108Polyphagia (HP:0002591)2.00031332
109Pheochromocytoma (HP:0002666)1.99664572
110Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.98819129
111Degeneration of the lateral corticospinal tracts (HP:0002314)1.98819129
112Pendular nystagmus (HP:0012043)1.98552375
113Ankyloglossia (HP:0010296)1.98270735
114Intestinal atresia (HP:0011100)1.94081785
115Poor coordination (HP:0002370)1.91996626
116Difficulty climbing stairs (HP:0003551)1.91953801
117Chronic hepatic failure (HP:0100626)1.91674662
118Amblyopia (HP:0000646)1.91417055
119Epileptiform EEG discharges (HP:0011182)1.90918038
120EEG with generalized epileptiform discharges (HP:0011198)1.90831664
121Hypoplasia of the fovea (HP:0007750)1.90786403
122Aplasia/Hypoplasia of the fovea (HP:0008060)1.90786403
123Papillary thyroid carcinoma (HP:0002895)1.90464291
124Abnormality of the renal cortex (HP:0011035)1.89983100
125Open mouth (HP:0000194)1.89702674
126Hyperventilation (HP:0002883)1.89491335
127Inappropriate behavior (HP:0000719)1.88824570
128Specific learning disability (HP:0001328)1.88399015
129Abnormality of the parathyroid morphology (HP:0011766)1.88006341
130Hamartoma of the eye (HP:0010568)1.87978104
131Overriding aorta (HP:0002623)1.87651374
132Agitation (HP:0000713)1.87542294
133Pachygyria (HP:0001302)1.87362625
134Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.87333839
135Short 1st metacarpal (HP:0010034)1.87333839
136Hypsarrhythmia (HP:0002521)1.87058637
137Limb dystonia (HP:0002451)1.85939894
138Lissencephaly (HP:0001339)1.84270885
139Apathy (HP:0000741)1.83996355
140Spinal rigidity (HP:0003306)1.83662276
141Abnormality of chromosome stability (HP:0003220)1.83026324
142Stereotypic behavior (HP:0000733)1.82734765
143Aqueductal stenosis (HP:0002410)1.81693915
144Decreased central vision (HP:0007663)1.81609740
145Hemiplegia (HP:0002301)1.81424478
146Abnormality of the renal medulla (HP:0100957)1.80984591
147Abnormality of vitamin B metabolism (HP:0004340)1.79216279
148Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79164942
149Abnormality of the vitamin B12 metabolism (HP:0004341)1.78560271
150Renal hypoplasia (HP:0000089)1.77687591
151Congenital stationary night blindness (HP:0007642)1.76006027
152Protruding tongue (HP:0010808)1.75794564
153Neuroendocrine neoplasm (HP:0100634)1.75067989
154Aplasia/Hypoplasia of the uvula (HP:0010293)1.74019570
155Neoplasm of the oral cavity (HP:0100649)1.73873182
156Astigmatism (HP:0000483)1.73803154
157Medulloblastoma (HP:0002885)1.70995889
158Bony spicule pigmentary retinopathy (HP:0007737)1.70550986
159Progressive macrocephaly (HP:0004481)1.69051196
160Decreased electroretinogram (ERG) amplitude (HP:0000654)1.68654151
161Benign neoplasm of the central nervous system (HP:0100835)1.68554990
162Optic nerve hypoplasia (HP:0000609)1.67350406
163Abnormality of the fovea (HP:0000493)1.66897674
164Thyroid carcinoma (HP:0002890)1.66055632
165Aplasia/Hypoplasia of the sternum (HP:0006714)1.65591625
166Abnormal hair whorl (HP:0010721)1.65397277
167Ketoacidosis (HP:0001993)1.61959904
168Ectopic kidney (HP:0000086)1.61853909
169Goiter (HP:0000853)1.61348953

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.34294196
2MARK14.24708806
3PNCK3.63177443
4NTRK33.39415609
5EPHA43.29800798
6MAP3K93.26789523
7MINK12.66141681
8NTRK22.51296581
9TRIM282.47063197
10MAP3K42.43220155
11PAK62.41097583
12MAP4K22.13344727
13BMPR1B2.06570329
14KSR22.02478312
15KSR12.00870396
16FES1.99121861
17CAMK1G1.96839940
18NUAK11.86418201
19NTRK11.80283115
20CSNK1G21.72962168
21DAPK21.68232368
22CAMKK11.66129670
23TYRO31.60254936
24SIK21.58878624
25ACVR1B1.58363203
26CSNK1A1L1.58054410
27MKNK21.56371608
28PRKD31.51062397
29CSNK1G31.48982099
30PINK11.48506876
31ZAK1.45095175
32UHMK11.44373248
33ALK1.42678314
34CDK51.42217252
35TSSK61.41364215
36PLK31.41241155
37MAP2K41.40241417
38MAP2K71.34153357
39CASK1.29750270
40CCNB11.29162320
41CAMKK21.24247281
42WNK11.22087729
43SCYL21.19521126
44DYRK21.18234959
45MKNK11.16165300
46LATS21.13774911
47CSNK1G11.11672388
48SRPK11.10453130
49PRKCG1.08725313
50GRK11.08342774
51SGK4941.07273049
52SGK2231.07273049
53MST41.07174861
54PRPF4B1.07059925
55YES11.03945147
56PHKG21.02213682
57PHKG11.02213682
58EPHA30.99213104
59MAP3K20.98721460
60TAOK30.98536204
61PLK20.98410598
62RIPK40.96839759
63MAPK130.95480333
64ICK0.92693339
65PLK40.91710790
66OXSR10.90552764
67STK380.89687317
68ADRBK20.88059496
69SGK30.86913695
70CDK180.85966934
71MARK20.85294921
72CDK140.85114816
73RET0.85084115
74STK110.84570894
75CDK150.83711121
76SGK20.82344061
77PRKCE0.81708707
78INSRR0.81708459
79FER0.81431335
80STK390.78467382
81DAPK10.77914647
82RIPK10.77633273
83PAK30.74534743
84CAMK10.74410166
85SGK10.73522114
86CDK11A0.70845166
87PRKCH0.70662751
88RAF10.69007282
89ARAF0.68670271
90DYRK1A0.68459403
91FGFR20.66242458
92STK38L0.65580421
93CAMK2A0.65425361
94PDK20.63577147
95OBSCN0.62136783
96CDK190.61433889
97PLK10.60651847
98PRKCZ0.59855429
99DYRK30.59594049
100CAMK2B0.58659432
101GRK50.58358709
102CAMK1D0.58057258
103MAP3K120.57660457
104WNK30.57596384
105ADRBK10.57050402
106SIK30.56789363
107NEK10.56246544
108CSNK1D0.55315059
109RPS6KA30.54329020
110MAP3K70.54228218
111TNK20.53706179
112TNIK0.53684229
113CAMK2G0.53069614
114FGR0.53002224
115BUB10.52434528
116MAPK100.51211446
117EIF2AK30.51171699
118FYN0.50863287
119BRSK20.50705940
120ERBB30.50245895
121BCKDK0.49766400
122CSNK1E0.48577694
123MARK30.48220620
124EIF2AK10.48068165
125FGFR10.46845562
126CAMK40.46624505
127CSNK1A10.45286590
128WNK40.45273401
129PDGFRA0.44697446
130ATR0.43853110
131LMTK20.43549990
132ERBB20.43361273
133BCR0.42858895
134ROCK20.42459543
135TAOK10.40822852
136PDK40.40413830
137PDK30.40413830
138PDPK10.38655467
139WEE10.38542754
140PDK10.38261284
141MAPK80.38010555
142GSK3B0.37183450
143ATM0.37179583
144PKN10.36862754
145NEK60.36774252
146PRKACB0.35933771
147EIF2AK20.34156943
148CDC70.33727427
149EGFR0.33106652
150PRKACA0.30908200

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.42032060
2Synaptic vesicle cycle_Homo sapiens_hsa047212.87567309
3GABAergic synapse_Homo sapiens_hsa047272.49376871
4Glutamatergic synapse_Homo sapiens_hsa047242.47218331
5Circadian entrainment_Homo sapiens_hsa047132.46957214
6Long-term potentiation_Homo sapiens_hsa047202.45804234
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.34276942
8Amphetamine addiction_Homo sapiens_hsa050312.26308792
9Non-homologous end-joining_Homo sapiens_hsa034502.22355149
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.21770728
11Morphine addiction_Homo sapiens_hsa050322.19795791
12Olfactory transduction_Homo sapiens_hsa047402.16268890
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.12143935
14Dopaminergic synapse_Homo sapiens_hsa047282.11441299
15Fanconi anemia pathway_Homo sapiens_hsa034602.10550150
16Propanoate metabolism_Homo sapiens_hsa006402.09835424
17Long-term depression_Homo sapiens_hsa047302.02193632
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.97817081
19Salivary secretion_Homo sapiens_hsa049701.95070104
20Steroid biosynthesis_Homo sapiens_hsa001001.89964669
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.86965929
22Cocaine addiction_Homo sapiens_hsa050301.84771241
23Nitrogen metabolism_Homo sapiens_hsa009101.81393034
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.79909035
25Cholinergic synapse_Homo sapiens_hsa047251.78428164
26Renin secretion_Homo sapiens_hsa049241.73771932
27Protein export_Homo sapiens_hsa030601.72109128
28Gastric acid secretion_Homo sapiens_hsa049711.70354904
29Basal transcription factors_Homo sapiens_hsa030221.65818630
30Selenocompound metabolism_Homo sapiens_hsa004501.60749670
31Insulin secretion_Homo sapiens_hsa049111.60474346
32Gap junction_Homo sapiens_hsa045401.57014518
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.54511827
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.54464519
35Oxytocin signaling pathway_Homo sapiens_hsa049211.51690969
36Regulation of autophagy_Homo sapiens_hsa041401.48843130
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.46911000
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.41893697
39Serotonergic synapse_Homo sapiens_hsa047261.39130300
40Axon guidance_Homo sapiens_hsa043601.38803847
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.37792138
42Dorso-ventral axis formation_Homo sapiens_hsa043201.37611702
43Estrogen signaling pathway_Homo sapiens_hsa049151.37023224
44Glioma_Homo sapiens_hsa052141.36560492
45Circadian rhythm_Homo sapiens_hsa047101.33143378
46GnRH signaling pathway_Homo sapiens_hsa049121.28863595
47Taste transduction_Homo sapiens_hsa047421.28716143
48ErbB signaling pathway_Homo sapiens_hsa040121.28379736
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.26628853
50RNA degradation_Homo sapiens_hsa030181.25584541
51RNA polymerase_Homo sapiens_hsa030201.24136434
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.23360132
53Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.23265090
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.22123597
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21741747
56cAMP signaling pathway_Homo sapiens_hsa040241.20022621
57Homologous recombination_Homo sapiens_hsa034401.18937850
58Fatty acid elongation_Homo sapiens_hsa000621.17713179
59Endometrial cancer_Homo sapiens_hsa052131.17393519
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.16294566
61Calcium signaling pathway_Homo sapiens_hsa040201.15959795
62Oocyte meiosis_Homo sapiens_hsa041141.14336646
63Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13521934
64Type II diabetes mellitus_Homo sapiens_hsa049301.12564926
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12510346
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11818614
67Melanogenesis_Homo sapiens_hsa049161.08567202
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05199932
69Phospholipase D signaling pathway_Homo sapiens_hsa040721.03873190
70Oxidative phosphorylation_Homo sapiens_hsa001901.03590745
71Fatty acid metabolism_Homo sapiens_hsa012121.01817954
72Ether lipid metabolism_Homo sapiens_hsa005651.01291692
73beta-Alanine metabolism_Homo sapiens_hsa004100.98443226
74Peroxisome_Homo sapiens_hsa041460.97220952
75Collecting duct acid secretion_Homo sapiens_hsa049660.96927458
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95696315
77Renal cell carcinoma_Homo sapiens_hsa052110.89145808
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.87199666
79Tryptophan metabolism_Homo sapiens_hsa003800.87103048
80Choline metabolism in cancer_Homo sapiens_hsa052310.86942645
81Proteasome_Homo sapiens_hsa030500.86115388
82Mismatch repair_Homo sapiens_hsa034300.83782701
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81951655
84mTOR signaling pathway_Homo sapiens_hsa041500.81165679
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80221900
86Colorectal cancer_Homo sapiens_hsa052100.78752274
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78509292
88Non-small cell lung cancer_Homo sapiens_hsa052230.78288127
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77017077
90MAPK signaling pathway_Homo sapiens_hsa040100.75978920
91Vitamin B6 metabolism_Homo sapiens_hsa007500.74650832
92Thyroid hormone synthesis_Homo sapiens_hsa049180.74144612
93VEGF signaling pathway_Homo sapiens_hsa043700.73525562
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.71591382
95Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71527149
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.71401493
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70039031
98Endocytosis_Homo sapiens_hsa041440.69316662
99Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.68909503
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68756132
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.68745371
102Parkinsons disease_Homo sapiens_hsa050120.68500067
103Glycerolipid metabolism_Homo sapiens_hsa005610.67845313
104Wnt signaling pathway_Homo sapiens_hsa043100.67745369
105Alcoholism_Homo sapiens_hsa050340.64816471
106Rap1 signaling pathway_Homo sapiens_hsa040150.64356225
107Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63542383
108Base excision repair_Homo sapiens_hsa034100.62947716
109Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62516851
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60952972
111Ras signaling pathway_Homo sapiens_hsa040140.58883462
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57615028
113Linoleic acid metabolism_Homo sapiens_hsa005910.56018311
114Inositol phosphate metabolism_Homo sapiens_hsa005620.55990615
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55364902
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54756781
117Pancreatic secretion_Homo sapiens_hsa049720.53778744
118Phototransduction_Homo sapiens_hsa047440.53369642
119Fatty acid biosynthesis_Homo sapiens_hsa000610.53305508
120Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53237913
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52192608
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52060024
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51672410
124Insulin signaling pathway_Homo sapiens_hsa049100.50830739
125Dilated cardiomyopathy_Homo sapiens_hsa054140.50687396
126Sulfur metabolism_Homo sapiens_hsa009200.50488274
127Glucagon signaling pathway_Homo sapiens_hsa049220.50339860
128Vibrio cholerae infection_Homo sapiens_hsa051100.50003593
129Fatty acid degradation_Homo sapiens_hsa000710.49406030
1302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49362369
131Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48881655
132Hippo signaling pathway_Homo sapiens_hsa043900.48257683
133Alzheimers disease_Homo sapiens_hsa050100.47115241
134Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46851750
135Cardiac muscle contraction_Homo sapiens_hsa042600.46588170
136Huntingtons disease_Homo sapiens_hsa050160.46521377
137Cysteine and methionine metabolism_Homo sapiens_hsa002700.46320035
138Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46275023
139Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46231835
140Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45552135
141Tight junction_Homo sapiens_hsa045300.43532886
142Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43383000
143Hedgehog signaling pathway_Homo sapiens_hsa043400.43061338
144Butanoate metabolism_Homo sapiens_hsa006500.42686724
145Bile secretion_Homo sapiens_hsa049760.42350515
146Prion diseases_Homo sapiens_hsa050200.41384935
147Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40905002
148Central carbon metabolism in cancer_Homo sapiens_hsa052300.40797512
149Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38660824
150Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38658682
151Melanoma_Homo sapiens_hsa052180.38169149
152Purine metabolism_Homo sapiens_hsa002300.37408430
153Lysine degradation_Homo sapiens_hsa003100.37213049
154Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37134433
155Metabolic pathways_Homo sapiens_hsa011000.34073926
156ABC transporters_Homo sapiens_hsa020100.33390223
157Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33181772

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