

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | positive regulation of gamma-delta T cell activation (GO:0046645) | 5.40632309 |
| 2 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 5.32257308 |
| 3 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 4.96065648 |
| 4 | positive regulation of antigen processing and presentation (GO:0002579) | 4.81044750 |
| 5 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 4.62123503 |
| 6 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 4.62123503 |
| 7 | modulation by symbiont of host immune response (GO:0052553) | 4.62123503 |
| 8 | positive regulation by symbiont of host defense response (GO:0052509) | 4.62123503 |
| 9 | modulation by symbiont of host defense response (GO:0052031) | 4.62123503 |
| 10 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 4.62123503 |
| 11 | germinal center formation (GO:0002467) | 4.45763832 |
| 12 | regulation of interferon-beta biosynthetic process (GO:0045357) | 4.34580062 |
| 13 | microglial cell activation (GO:0001774) | 4.21531942 |
| 14 | positive regulation of B cell differentiation (GO:0045579) | 4.17354685 |
| 15 | B cell receptor signaling pathway (GO:0050853) | 4.15656359 |
| 16 | macrophage activation involved in immune response (GO:0002281) | 4.10702823 |
| 17 | negative regulation of granulocyte differentiation (GO:0030853) | 4.09965217 |
| 18 | positive regulation of Cdc42 GTPase activity (GO:0043089) | 3.98963882 |
| 19 | response to muramyl dipeptide (GO:0032495) | 3.91866589 |
| 20 | negative regulation of cell killing (GO:0031342) | 3.80818793 |
| 21 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 3.80818793 |
| 22 | regulation of B cell receptor signaling pathway (GO:0050855) | 3.80120976 |
| 23 | regulation of Cdc42 GTPase activity (GO:0043088) | 3.78946657 |
| 24 | regulation of antigen processing and presentation (GO:0002577) | 3.75144297 |
| 25 | activated T cell proliferation (GO:0050798) | 3.73006334 |
| 26 | I-kappaB phosphorylation (GO:0007252) | 3.66252366 |
| 27 | regulation of gamma-delta T cell activation (GO:0046643) | 3.64288965 |
| 28 | determination of adult lifespan (GO:0008340) | 3.62131541 |
| 29 | positive thymic T cell selection (GO:0045059) | 3.56817278 |
| 30 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 3.54875835 |
| 31 | regulation of gamma-delta T cell differentiation (GO:0045586) | 3.54643706 |
| 32 | positive regulation of interferon-alpha production (GO:0032727) | 3.54089861 |
| 33 | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369) | 3.52672516 |
| 34 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 3.46078879 |
| 35 | negative T cell selection (GO:0043383) | 3.44844647 |
| 36 | NIK/NF-kappaB signaling (GO:0038061) | 3.44281763 |
| 37 | cellular response to ethanol (GO:0071361) | 3.43849744 |
| 38 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 3.34952620 |
| 39 | regulation of interferon-alpha production (GO:0032647) | 3.33865743 |
| 40 | neutrophil mediated immunity (GO:0002446) | 3.33071258 |
| 41 | neutrophil activation (GO:0042119) | 3.27602797 |
| 42 | interferon-gamma-mediated signaling pathway (GO:0060333) | 3.22588899 |
| 43 | macrophage activation (GO:0042116) | 3.15160165 |
| 44 | neutrophil activation involved in immune response (GO:0002283) | 3.14864359 |
| 45 | regulation of B cell differentiation (GO:0045577) | 3.14850827 |
| 46 | modulation by symbiont of host cellular process (GO:0044068) | 3.14090702 |
| 47 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 3.13833178 |
| 48 | respiratory burst (GO:0045730) | 3.06788088 |
| 49 | response to host immune response (GO:0052572) | 3.05871849 |
| 50 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 3.05871849 |
| 51 | cellular extravasation (GO:0045123) | 3.05747391 |
| 52 | detection of other organism (GO:0098543) | 3.05396053 |
| 53 | positive regulation of cellular amide metabolic process (GO:0034250) | 3.03449844 |
| 54 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 3.03105106 |
| 55 | interferon-gamma production (GO:0032609) | 3.02368739 |
| 56 | detection of bacterium (GO:0016045) | 3.01248490 |
| 57 | pinocytosis (GO:0006907) | 2.99880546 |
| 58 | granulocyte activation (GO:0036230) | 2.99010654 |
| 59 | regulation of germinal center formation (GO:0002634) | 2.98030002 |
| 60 | negative regulation of bone resorption (GO:0045779) | 2.97681018 |
| 61 | positive regulation of Rap GTPase activity (GO:0032854) | 2.97043232 |
| 62 | immunoglobulin mediated immune response (GO:0016064) | 2.96946714 |
| 63 | B cell homeostasis (GO:0001782) | 2.96054599 |
| 64 | T cell selection (GO:0045058) | 2.94544865 |
| 65 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 2.93702802 |
| 66 | positive regulation of interleukin-1 beta secretion (GO:0050718) | 2.93106755 |
| 67 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 2.92852380 |
| 68 | positive regulation of interleukin-8 biosynthetic process (GO:0045416) | 2.90991008 |
| 69 | histone H3-K4 trimethylation (GO:0080182) | 2.89932588 |
| 70 | positive regulation of granulocyte chemotaxis (GO:0071624) | 2.89749378 |
| 71 | cellular response to ATP (GO:0071318) | 2.88967612 |
| 72 | T cell migration (GO:0072678) | 2.87698956 |
| 73 | myeloid cell activation involved in immune response (GO:0002275) | 2.87631623 |
| 74 | response to type I interferon (GO:0034340) | 2.83629574 |
| 75 | positive regulation of granulocyte differentiation (GO:0030854) | 2.81664533 |
| 76 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 2.80341280 |
| 77 | response to host (GO:0075136) | 2.80341280 |
| 78 | response to host defenses (GO:0052200) | 2.80341280 |
| 79 | negative regulation of interleukin-6 production (GO:0032715) | 2.79893874 |
| 80 | type I interferon signaling pathway (GO:0060337) | 2.79673819 |
| 81 | cellular response to type I interferon (GO:0071357) | 2.79673819 |
| 82 | T cell proliferation (GO:0042098) | 2.78506672 |
| 83 | positive regulation of cell adhesion mediated by integrin (GO:0033630) | 2.76657049 |
| 84 | autophagic vacuole fusion (GO:0000046) | 2.76162620 |
| 85 | pericardium development (GO:0060039) | 2.75705988 |
| 86 | thymic T cell selection (GO:0045061) | 2.74146170 |
| 87 | positive regulation of interleukin-12 production (GO:0032735) | 2.72919614 |
| 88 | negative regulation of T cell mediated immunity (GO:0002710) | 2.71829087 |
| 89 | positive regulation of interleukin-1 secretion (GO:0050716) | 2.71331217 |
| 90 | positive regulation of cholesterol efflux (GO:0010875) | 2.70979889 |
| 91 | negative regulation of interleukin-12 production (GO:0032695) | 2.69745569 |
| 92 | regulation of alpha-beta T cell proliferation (GO:0046640) | 2.68688269 |
| 93 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 2.67857991 |
| 94 | detection of external biotic stimulus (GO:0098581) | 2.66506285 |
| 95 | T cell mediated immunity (GO:0002456) | 2.65998514 |
| 96 | B cell proliferation (GO:0042100) | 2.65626062 |
| 97 | T-helper 1 type immune response (GO:0042088) | 2.65095050 |
| 98 | response to peptidoglycan (GO:0032494) | 2.63789097 |
| 99 | myeloid dendritic cell activation (GO:0001773) | 2.63573487 |
| 100 | positive T cell selection (GO:0043368) | 2.61980243 |
| 101 | organelle membrane fusion (GO:0090174) | 2.61591136 |
| 102 | antigen processing and presentation of endogenous antigen (GO:0019883) | 2.61341970 |
| 103 | response to protozoan (GO:0001562) | 2.61306347 |
| 104 | response to lipoprotein particle (GO:0055094) | 2.59897578 |
| 105 | cytidine deamination (GO:0009972) | 2.59521786 |
| 106 | cytidine metabolic process (GO:0046087) | 2.59521786 |
| 107 | cytidine catabolic process (GO:0006216) | 2.59521786 |
| 108 | natural killer cell mediated cytotoxicity (GO:0042267) | 2.59190831 |
| 109 | natural killer cell mediated immunity (GO:0002228) | 2.59190831 |
| 110 | regulation of B cell proliferation (GO:0030888) | 2.59109839 |
| 111 | detection of molecule of bacterial origin (GO:0032490) | 2.58579939 |
| 112 | leukocyte mediated cytotoxicity (GO:0001909) | 2.58371489 |
| 113 | regulation of mast cell activation (GO:0033003) | 2.58100140 |
| 114 | negative regulation of B cell proliferation (GO:0030889) | 2.57112333 |
| 115 | regulation of Rap GTPase activity (GO:0032317) | 2.57095364 |
| 116 | leukocyte cell-cell adhesion (GO:0007159) | 2.55833495 |
| 117 | myeloid leukocyte activation (GO:0002274) | 2.54865010 |
| 118 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 2.54829367 |
| 119 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 2.54204701 |
| 120 | positive regulation of B cell proliferation (GO:0030890) | 2.53986609 |
| 121 | N-acetylneuraminate metabolic process (GO:0006054) | 2.53289031 |
| 122 | adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli | 2.52694619 |
| 123 | negative thymic T cell selection (GO:0045060) | 2.51843729 |
| 124 | antigen receptor-mediated signaling pathway (GO:0050851) | 2.50984041 |
| 125 | tolerance induction (GO:0002507) | 2.50203617 |
| 126 | positive regulation of interferon-beta production (GO:0032728) | 2.50170286 |
| 127 | G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589) | 2.49545786 |
| 128 | purine ribonucleotide transport (GO:0015868) | 2.48971265 |
| 129 | positive regulation of interferon-gamma biosynthetic process (GO:0045078) | 2.48767778 |
| 130 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 2.48622021 |
| 131 | positive regulation of mast cell activation (GO:0033005) | 2.48106553 |
| 132 | positive regulation of neutrophil migration (GO:1902624) | 2.47524687 |
| 133 | positive regulation of neutrophil chemotaxis (GO:0090023) | 2.47524687 |
| 134 | regulation of interleukin-1 beta secretion (GO:0050706) | 2.47220983 |
| 135 | negative regulation of interleukin-17 production (GO:0032700) | 2.46296006 |
| 136 | defense response to protozoan (GO:0042832) | 2.46278667 |
| 137 | cellular response to interleukin-15 (GO:0071350) | 2.46260939 |
| 138 | cellular response to exogenous dsRNA (GO:0071360) | 2.45850855 |
| 139 | myeloid dendritic cell differentiation (GO:0043011) | 2.45652896 |
| 140 | lymphocyte proliferation (GO:0046651) | 2.45356338 |
| 141 | negative regulation of alpha-beta T cell activation (GO:0046636) | 2.45062881 |
| 142 | mononuclear cell proliferation (GO:0032943) | 2.44614023 |
| 143 | dendritic cell differentiation (GO:0097028) | 2.44338512 |
| 144 | regulation of T-helper 1 cell differentiation (GO:0045625) | 2.43666549 |
| 145 | mannose metabolic process (GO:0006013) | 2.40609638 |
| 146 | negative regulation of protein oligomerization (GO:0032460) | 2.39913807 |
| 147 | positive regulation of defense response to virus by host (GO:0002230) | 2.39212741 |
| 148 | positive regulation of B cell activation (GO:0050871) | 2.37673460 |
| 149 | regulation of tumor necrosis factor biosynthetic process (GO:0042534) | 2.36641421 |
| 150 | T cell costimulation (GO:0031295) | 2.36198702 |
| 151 | mast cell activation (GO:0045576) | 2.34732931 |
| 152 | regulation of MHC class I biosynthetic process (GO:0045343) | 2.34317867 |
| 153 | response to interleukin-15 (GO:0070672) | 2.32699240 |
| 154 | T cell lineage commitment (GO:0002360) | 2.32565564 |
| 155 | lymphocyte costimulation (GO:0031294) | 2.32518828 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 4.38876520 |
| 2 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 4.04739185 |
| 3 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 3.54147121 |
| 4 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 3.38791788 |
| 5 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 3.09647562 |
| 6 | * Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 3.08193349 |
| 7 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 3.01020074 |
| 8 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 3.00214407 |
| 9 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.54843462 |
| 10 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.50132830 |
| 11 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.44820174 |
| 12 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.38005206 |
| 13 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 2.26206476 |
| 14 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 2.22225698 |
| 15 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.13423584 |
| 16 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.04713811 |
| 17 | RUNX_20019798_ChIP-Seq_JUKART_Human | 2.00935638 |
| 18 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.99491144 |
| 19 | * SPI1_23127762_ChIP-Seq_K562_Human | 1.91745151 |
| 20 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.79576238 |
| 21 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.77859127 |
| 22 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.74380648 |
| 23 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.73330392 |
| 24 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.68334325 |
| 25 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.66183851 |
| 26 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.62703083 |
| 27 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.60705621 |
| 28 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.59744643 |
| 29 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.54455401 |
| 30 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.53558794 |
| 31 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.52341833 |
| 32 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.50867468 |
| 33 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.49816601 |
| 34 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.47021094 |
| 35 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.46792032 |
| 36 | GATA3_26560356_Chip-Seq_TH2_Human | 1.40771687 |
| 37 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.39859651 |
| 38 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.34175826 |
| 39 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.30243592 |
| 40 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.29726904 |
| 41 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.28975194 |
| 42 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 1.26241472 |
| 43 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.24558269 |
| 44 | GATA1_19941826_ChIP-Seq_K562_Human | 1.23340488 |
| 45 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.23327365 |
| 46 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.21972257 |
| 47 | GATA1_22025678_ChIP-Seq_K562_Human | 1.18144018 |
| 48 | * ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.16530482 |
| 49 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.15195057 |
| 50 | TP53_16413492_ChIP-PET_HCT116_Human | 1.13225419 |
| 51 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.12040522 |
| 52 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.11032640 |
| 53 | * SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.10887480 |
| 54 | MYB_26560356_Chip-Seq_TH1_Human | 1.09837813 |
| 55 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.09178346 |
| 56 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.08810865 |
| 57 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.07270419 |
| 58 | * PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.07188620 |
| 59 | * FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.06726572 |
| 60 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.06472023 |
| 61 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.06226357 |
| 62 | MYB_26560356_Chip-Seq_TH2_Human | 1.05476215 |
| 63 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.05387969 |
| 64 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.04786302 |
| 65 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.03121523 |
| 66 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.01128278 |
| 67 | * ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.00053263 |
| 68 | GBX2_23144817_ChIP-Seq_PC3_Human | 0.99168822 |
| 69 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.99097155 |
| 70 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.98350344 |
| 71 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 0.97518988 |
| 72 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.97318322 |
| 73 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.95826101 |
| 74 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.95291391 |
| 75 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.94766155 |
| 76 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.94766155 |
| 77 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.94246965 |
| 78 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.93855618 |
| 79 | * TCF4_23295773_ChIP-Seq_U87_Human | 0.93628959 |
| 80 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.92596824 |
| 81 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 0.92564389 |
| 82 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.92448479 |
| 83 | MYC_22102868_ChIP-Seq_BL_Human | 0.92324425 |
| 84 | ELK4_26923725_Chip-Seq_MESODERM_Mouse | 0.91399903 |
| 85 | MAF_26560356_Chip-Seq_TH1_Human | 0.90775968 |
| 86 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.90252063 |
| 87 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 0.89975323 |
| 88 | GATA2_19941826_ChIP-Seq_K562_Human | 0.89293268 |
| 89 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.88502141 |
| 90 | SMAD4_21799915_ChIP-Seq_A2780_Human | 0.88098943 |
| 91 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 0.88002438 |
| 92 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 0.87499241 |
| 93 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 0.87377552 |
| 94 | AR_21572438_ChIP-Seq_LNCaP_Human | 0.87235849 |
| 95 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.87210350 |
| 96 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 0.86806525 |
| 97 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.86495226 |
| 98 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 0.85611600 |
| 99 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.85154330 |
| 100 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.83618261 |
| 101 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.83230649 |
| 102 | RXR_22108803_ChIP-Seq_LS180_Human | 0.82958848 |
| 103 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.82581961 |
| 104 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 0.82568566 |
| 105 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.82500924 |
| 106 | * TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.82239791 |
| 107 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.82113010 |
| 108 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 0.82059633 |
| 109 | AR_25329375_ChIP-Seq_VCAP_Human | 0.81959437 |
| 110 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 0.81433444 |
| 111 | STAT3_23295773_ChIP-Seq_U87_Human | 0.81210641 |
| 112 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.80977769 |
| 113 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.79107759 |
| 114 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.78978240 |
| 115 | * SMRT_27268052_Chip-Seq_Bcells_Human | 0.78844478 |
| 116 | TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.78295789 |
| 117 | * ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.78151660 |
| 118 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.78081106 |
| 119 | * WT1_25993318_ChIP-Seq_PODOCYTE_Human | 0.77950784 |
| 120 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 0.77742871 |
| 121 | TP63_23658742_ChIP-Seq_EP156T_Human | 0.77525050 |
| 122 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 0.77194178 |
| 123 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 0.76932386 |
| 124 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 0.76600896 |
| 125 | * TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.76326503 |
| 126 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.76199926 |
| 127 | * ESR2_21235772_ChIP-Seq_MCF-7_Human | 0.76195509 |
| 128 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 0.76091809 |
| 129 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.75080739 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0000569_abnormal_digit_pigmentation | 6.12278798 |
| 2 | MP0001835_abnormal_antigen_presentation | 4.83589075 |
| 3 | MP0002254_reproductive_system_inflammat | 4.43378062 |
| 4 | MP0003183_abnormal_peptide_metabolism | 3.27955952 |
| 5 | MP0003172_abnormal_lysosome_physiology | 3.25387184 |
| 6 | MP0000685_abnormal_immune_system | 3.22026780 |
| 7 | MP0006082_CNS_inflammation | 3.18641228 |
| 8 | MP0004510_myositis | 3.05414986 |
| 9 | MP0005387_immune_system_phenotype | 2.73128817 |
| 10 | MP0001790_abnormal_immune_system | 2.73128817 |
| 11 | MP0005058_abnormal_lysosome_morphology | 2.70010867 |
| 12 | MP0001800_abnormal_humoral_immune | 2.69615984 |
| 13 | MP0005671_abnormal_response_to | 2.46481019 |
| 14 | MP0002452_abnormal_antigen_presenting | 2.39477690 |
| 15 | MP0005310_abnormal_salivary_gland | 2.38382897 |
| 16 | MP0001873_stomach_inflammation | 2.37442413 |
| 17 | MP0003724_increased_susceptibility_to | 2.34224991 |
| 18 | MP0002419_abnormal_innate_immunity | 2.29665531 |
| 19 | MP0000015_abnormal_ear_pigmentation | 2.22567630 |
| 20 | MP0005464_abnormal_platelet_physiology | 2.20983466 |
| 21 | MP0002723_abnormal_immune_serum | 2.12133971 |
| 22 | MP0005000_abnormal_immune_tolerance | 2.03749595 |
| 23 | MP0005174_abnormal_tail_pigmentation | 1.99186242 |
| 24 | MP0001819_abnormal_immune_cell | 1.97936828 |
| 25 | MP0002420_abnormal_adaptive_immunity | 1.95423602 |
| 26 | MP0003300_gastrointestinal_ulcer | 1.86926575 |
| 27 | MP0002148_abnormal_hypersensitivity_rea | 1.85611171 |
| 28 | MP0009278_abnormal_bone_marrow | 1.84436842 |
| 29 | MP0005645_abnormal_hypothalamus_physiol | 1.83317912 |
| 30 | MP0002396_abnormal_hematopoietic_system | 1.76654354 |
| 31 | MP0005025_abnormal_response_to | 1.74454486 |
| 32 | MP0000371_diluted_coat_color | 1.70337020 |
| 33 | MP0002928_abnormal_bile_duct | 1.68453956 |
| 34 | MP0002166_altered_tumor_susceptibility | 1.61282110 |
| 35 | MP0003436_decreased_susceptibility_to | 1.58522176 |
| 36 | MP0000716_abnormal_immune_system | 1.53022651 |
| 37 | MP0008260_abnormal_autophagy | 1.50796002 |
| 38 | MP0002876_abnormal_thyroid_physiology | 1.49768529 |
| 39 | MP0002398_abnormal_bone_marrow | 1.48858551 |
| 40 | MP0003303_peritoneal_inflammation | 1.48166178 |
| 41 | MP0002693_abnormal_pancreas_physiology | 1.47571944 |
| 42 | MP0002405_respiratory_system_inflammati | 1.46705366 |
| 43 | MP0001346_abnormal_lacrimal_gland | 1.35934702 |
| 44 | MP0004947_skin_inflammation | 1.35028833 |
| 45 | MP0002138_abnormal_hepatobiliary_system | 1.31756227 |
| 46 | MP0000689_abnormal_spleen_morphology | 1.31471462 |
| 47 | MP0003045_fibrosis | 1.31391841 |
| 48 | MP0004381_abnormal_hair_follicle | 1.28838682 |
| 49 | MP0005670_abnormal_white_adipose | 1.26150323 |
| 50 | MP0001845_abnormal_inflammatory_respons | 1.24906609 |
| 51 | MP0003191_abnormal_cellular_cholesterol | 1.23215959 |
| 52 | MP0000372_irregular_coat_pigmentation | 1.21198632 |
| 53 | MP0002722_abnormal_immune_system | 1.18379905 |
| 54 | MP0009785_altered_susceptibility_to | 1.18180410 |
| 55 | MP0005379_endocrine/exocrine_gland_phen | 1.17002338 |
| 56 | MP0002429_abnormal_blood_cell | 1.15558665 |
| 57 | MP0002006_tumorigenesis | 1.15299023 |
| 58 | MP0002933_joint_inflammation | 1.14721541 |
| 59 | MP0001853_heart_inflammation | 1.12456397 |
| 60 | MP0003195_calcinosis | 1.11939150 |
| 61 | MP0000465_gastrointestinal_hemorrhage | 1.10789416 |
| 62 | MP0003787_abnormal_imprinting | 1.10415881 |
| 63 | MP0008961_abnormal_basal_metabolism | 1.05812105 |
| 64 | MP0001958_emphysema | 1.05726869 |
| 65 | MP0008469_abnormal_protein_level | 1.05355069 |
| 66 | MP0000703_abnormal_thymus_morphology | 1.03678053 |
| 67 | MP0010386_abnormal_urinary_bladder | 1.02997249 |
| 68 | MP0001851_eye_inflammation | 0.98703789 |
| 69 | MP0004883_abnormal_blood_vessel | 0.98456151 |
| 70 | MP0005075_abnormal_melanosome_morpholog | 0.98001644 |
| 71 | MP0003763_abnormal_thymus_physiology | 0.97098219 |
| 72 | MP0010155_abnormal_intestine_physiology | 0.95604873 |
| 73 | MP0001986_abnormal_taste_sensitivity | 0.92639418 |
| 74 | MP0004043_abnormal_pH_regulation | 0.91312899 |
| 75 | MP0000604_amyloidosis | 0.91092710 |
| 76 | MP0009046_muscle_twitch | 0.89400777 |
| 77 | MP0002998_abnormal_bone_remodeling | 0.89350103 |
| 78 | MP0002136_abnormal_kidney_physiology | 0.87371657 |
| 79 | MP0009697_abnormal_copulation | 0.83673650 |
| 80 | MP0005167_abnormal_blood-brain_barrier | 0.83470680 |
| 81 | MP0001944_abnormal_pancreas_morphology | 0.82548235 |
| 82 | MP0005647_abnormal_sex_gland | 0.82225399 |
| 83 | MP0009333_abnormal_splenocyte_physiolog | 0.82104387 |
| 84 | MP0002163_abnormal_gland_morphology | 0.81351703 |
| 85 | MP0003656_abnormal_erythrocyte_physiolo | 0.80554377 |
| 86 | MP0009764_decreased_sensitivity_to | 0.80503748 |
| 87 | MP0006054_spinal_hemorrhage | 0.79133048 |
| 88 | MP0002075_abnormal_coat/hair_pigmentati | 0.78764813 |
| 89 | MP0000383_abnormal_hair_follicle | 0.76741931 |
| 90 | MP0004808_abnormal_hematopoietic_stem | 0.76595098 |
| 91 | MP0008057_abnormal_DNA_replication | 0.76404697 |
| 92 | MP0003690_abnormal_glial_cell | 0.76235365 |
| 93 | MP0001533_abnormal_skeleton_physiology | 0.74771118 |
| 94 | MP0002332_abnormal_exercise_endurance | 0.74723291 |
| 95 | MP0005164_abnormal_response_to | 0.74711855 |
| 96 | MP0000249_abnormal_blood_vessel | 0.74321310 |
| 97 | MP0005397_hematopoietic_system_phenotyp | 0.73961376 |
| 98 | MP0001545_abnormal_hematopoietic_system | 0.73961376 |
| 99 | MP0002909_abnormal_adrenal_gland | 0.73899405 |
| 100 | MP0001756_abnormal_urination | 0.73637270 |
| 101 | MP0003091_abnormal_cell_migration | 0.72869682 |
| 102 | MP0002168_other_aberrant_phenotype | 0.72274600 |
| 103 | MP0002078_abnormal_glucose_homeostasis | 0.71720164 |
| 104 | MP0008004_abnormal_stomach_pH | 0.71509022 |
| 105 | MP0003453_abnormal_keratinocyte_physiol | 0.71333706 |
| 106 | MP0005197_abnormal_uvea_morphology | 0.70198015 |
| 107 | MP0002009_preneoplasia | 0.69757808 |
| 108 | MP0005220_abnormal_exocrine_pancreas | 0.69286001 |
| 109 | MP0004142_abnormal_muscle_tone | 0.69132990 |
| 110 | MP0003866_abnormal_defecation | 0.68399744 |
| 111 | MP0009115_abnormal_fat_cell | 0.67845297 |
| 112 | MP0003633_abnormal_nervous_system | 0.67756826 |
| 113 | MP0010307_abnormal_tumor_latency | 0.67628349 |
| 114 | MP0000538_abnormal_urinary_bladder | 0.67556966 |
| 115 | MP0000767_abnormal_smooth_muscle | 0.67555155 |
| 116 | MP0005360_urolithiasis | 0.67057951 |
| 117 | MP0003075_altered_response_to | 0.65753647 |
| 118 | MP0000427_abnormal_hair_cycle | 0.64813337 |
| 119 | MP0002095_abnormal_skin_pigmentation | 0.63736145 |
| 120 | MP0002277_abnormal_respiratory_mucosa | 0.60824340 |
| 121 | MP0000920_abnormal_myelination | 0.60132961 |
| 122 | MP0009643_abnormal_urine_homeostasis | 0.59962091 |
| 123 | MP0009765_abnormal_xenobiotic_induced | 0.57503067 |
| 124 | MP0001324_abnormal_eye_pigmentation | 0.57005635 |
| 125 | MP0003252_abnormal_bile_duct | 0.56248283 |
| 126 | MP0005409_darkened_coat_color | 0.56163008 |
| 127 | MP0005166_decreased_susceptibility_to | 0.54341315 |
| 128 | MP0003795_abnormal_bone_structure | 0.54040181 |
| 129 | MP0009763_increased_sensitivity_to | 0.53363460 |
| 130 | MP0002735_abnormal_chemical_nociception | 0.51979238 |
| 131 | MP0009840_abnormal_foam_cell | 0.51847430 |
| 132 | MP0003566_abnormal_cell_adhesion | 0.51813060 |
| 133 | MP0003448_altered_tumor_morphology | 0.50487269 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Recurrent cutaneous fungal infections (HP:0011370) | 5.36293587 |
| 2 | Chronic mucocutaneous candidiasis (HP:0002728) | 5.36293587 |
| 3 | Recurrent bacterial skin infections (HP:0005406) | 4.89158279 |
| 4 | Colitis (HP:0002583) | 4.55303098 |
| 5 | Recurrent abscess formation (HP:0002722) | 4.54373109 |
| 6 | Recurrent fungal infections (HP:0002841) | 4.50778652 |
| 7 | Recurrent skin infections (HP:0001581) | 4.26332211 |
| 8 | Agammaglobulinemia (HP:0004432) | 4.14290288 |
| 9 | Panhypogammaglobulinemia (HP:0003139) | 4.10184917 |
| 10 | Eczematoid dermatitis (HP:0000976) | 3.84162623 |
| 11 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 3.65849403 |
| 12 | Tetany (HP:0001281) | 3.57776116 |
| 13 | Abnormality of the fingertips (HP:0001211) | 3.49850691 |
| 14 | Recurrent sinusitis (HP:0011108) | 3.48559392 |
| 15 | Inflammation of the large intestine (HP:0002037) | 3.46016268 |
| 16 | Recurrent viral infections (HP:0004429) | 3.43265935 |
| 17 | Glomerulonephritis (HP:0000099) | 3.40935481 |
| 18 | Systemic lupus erythematosus (HP:0002725) | 3.31505954 |
| 19 | Urethral obstruction (HP:0000796) | 3.25318778 |
| 20 | Double outlet right ventricle (HP:0001719) | 3.20778693 |
| 21 | Congenital malformation of the right heart (HP:0011723) | 3.20778693 |
| 22 | Hematochezia (HP:0002573) | 3.20591320 |
| 23 | Recurrent bronchitis (HP:0002837) | 3.17225247 |
| 24 | Gastrointestinal inflammation (HP:0004386) | 3.09597046 |
| 25 | Periodontitis (HP:0000704) | 2.91558532 |
| 26 | Increased cerebral lipofuscin (HP:0011813) | 2.89748922 |
| 27 | Gingivitis (HP:0000230) | 2.89196503 |
| 28 | Autoimmune thrombocytopenia (HP:0001973) | 2.87911657 |
| 29 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.86204332 |
| 30 | Premature loss of primary teeth (HP:0006323) | 2.75188108 |
| 31 | Arterial tortuosity (HP:0005116) | 2.71287545 |
| 32 | Thyroiditis (HP:0100646) | 2.71101698 |
| 33 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 2.67237633 |
| 34 | T lymphocytopenia (HP:0005403) | 2.66575722 |
| 35 | Osteomyelitis (HP:0002754) | 2.65079223 |
| 36 | Abnormality of T cell number (HP:0011839) | 2.64723004 |
| 37 | Abnormality of liposaccharide metabolism (HP:0010968) | 2.64518086 |
| 38 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 2.64518086 |
| 39 | Abnormality of glycolipid metabolism (HP:0010969) | 2.64518086 |
| 40 | Chronic diarrhea (HP:0002028) | 2.63086343 |
| 41 | Xerostomia (HP:0000217) | 2.62214556 |
| 42 | Orchitis (HP:0100796) | 2.60818820 |
| 43 | Albinism (HP:0001022) | 2.58121078 |
| 44 | Hemoptysis (HP:0002105) | 2.55405234 |
| 45 | Meningitis (HP:0001287) | 2.52414418 |
| 46 | Lymphopenia (HP:0001888) | 2.52240225 |
| 47 | Vasculitis (HP:0002633) | 2.48469383 |
| 48 | Abnormality of macrophages (HP:0004311) | 2.46368396 |
| 49 | Cellulitis (HP:0100658) | 2.40756852 |
| 50 | IgG deficiency (HP:0004315) | 2.40124992 |
| 51 | Verrucae (HP:0200043) | 2.38339174 |
| 52 | Papilloma (HP:0012740) | 2.38339174 |
| 53 | Thick nail (HP:0001805) | 2.36520281 |
| 54 | IgA deficiency (HP:0002720) | 2.36198905 |
| 55 | Abnormality of T cells (HP:0002843) | 2.35375680 |
| 56 | Obstructive lung disease (HP:0006536) | 2.33886864 |
| 57 | Chronic obstructive pulmonary disease (HP:0006510) | 2.33886864 |
| 58 | Abnormality of B cell number (HP:0010975) | 2.32419568 |
| 59 | Increased IgE level (HP:0003212) | 2.32412051 |
| 60 | Keratoconjunctivitis (HP:0001096) | 2.31979014 |
| 61 | Mucopolysacchariduria (HP:0008155) | 2.31700743 |
| 62 | Urinary glycosaminoglycan excretion (HP:0003541) | 2.31700743 |
| 63 | Increased CSF protein (HP:0002922) | 2.31409358 |
| 64 | Gastrointestinal infarctions (HP:0005244) | 2.30483382 |
| 65 | Peripheral demyelination (HP:0011096) | 2.27239591 |
| 66 | Eosinophilia (HP:0001880) | 2.25244646 |
| 67 | Abnormality of T cell physiology (HP:0011840) | 2.23996147 |
| 68 | Recurrent pneumonia (HP:0006532) | 2.23403323 |
| 69 | Pulmonary infiltrates (HP:0002113) | 2.22342519 |
| 70 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 2.22188563 |
| 71 | Vascular tortuosity (HP:0004948) | 2.21493850 |
| 72 | Complement deficiency (HP:0004431) | 2.20894169 |
| 73 | Prostate neoplasm (HP:0100787) | 2.18468971 |
| 74 | Pustule (HP:0200039) | 2.17787997 |
| 75 | Nephritis (HP:0000123) | 2.16835816 |
| 76 | Gastrointestinal stroma tumor (HP:0100723) | 2.14837194 |
| 77 | Vacuolated lymphocytes (HP:0001922) | 2.14360758 |
| 78 | Lip pit (HP:0100267) | 2.12924483 |
| 79 | Recurrent lower respiratory tract infections (HP:0002783) | 2.11679348 |
| 80 | Mediastinal lymphadenopathy (HP:0100721) | 2.11664532 |
| 81 | Pathologic fracture (HP:0002756) | 2.08679634 |
| 82 | Spontaneous hematomas (HP:0007420) | 2.07816132 |
| 83 | Large for gestational age (HP:0001520) | 2.07272109 |
| 84 | Stomach cancer (HP:0012126) | 2.06105967 |
| 85 | Axonal loss (HP:0003447) | 2.06085015 |
| 86 | Widely spaced teeth (HP:0000687) | 2.05801859 |
| 87 | Hypoplasia of the thymus (HP:0000778) | 2.04758325 |
| 88 | Abnormality of eosinophils (HP:0001879) | 2.04744926 |
| 89 | Severe combined immunodeficiency (HP:0004430) | 2.03333667 |
| 90 | Thoracic kyphosis (HP:0002942) | 2.03026554 |
| 91 | B lymphocytopenia (HP:0010976) | 2.02148334 |
| 92 | Global brain atrophy (HP:0002283) | 2.01684507 |
| 93 | Spinal muscular atrophy (HP:0007269) | 2.00950592 |
| 94 | Arthropathy (HP:0003040) | 2.00534847 |
| 95 | Hyperventilation (HP:0002883) | 1.98063916 |
| 96 | Leukocytosis (HP:0001974) | 1.97171298 |
| 97 | Bronchiectasis (HP:0002110) | 1.96842928 |
| 98 | Bronchitis (HP:0012387) | 1.96790008 |
| 99 | Prolonged bleeding time (HP:0003010) | 1.95564580 |
| 100 | Loss of speech (HP:0002371) | 1.95291029 |
| 101 | Hypoplastic ischia (HP:0003175) | 1.94307667 |
| 102 | Restrictive lung disease (HP:0002091) | 1.92069272 |
| 103 | Chronic sinusitis (HP:0011109) | 1.91874440 |
| 104 | Abnormality of the pleura (HP:0002103) | 1.91309416 |
| 105 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.91194009 |
| 106 | Vertebral arch anomaly (HP:0008438) | 1.90914538 |
| 107 | Abnormality of complement system (HP:0005339) | 1.87862029 |
| 108 | Polydipsia (HP:0001959) | 1.87811693 |
| 109 | Abnormal drinking behavior (HP:0030082) | 1.87811693 |
| 110 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 1.86698645 |
| 111 | Viral hepatitis (HP:0006562) | 1.86068270 |
| 112 | Optic neuritis (HP:0100653) | 1.85720586 |
| 113 | Retrobulbar optic neuritis (HP:0100654) | 1.85720586 |
| 114 | Chromsome breakage (HP:0040012) | 1.85717461 |
| 115 | Encephalitis (HP:0002383) | 1.85328518 |
| 116 | Myositis (HP:0100614) | 1.83636254 |
| 117 | Epistaxis (HP:0000421) | 1.83320174 |
| 118 | Chronic otitis media (HP:0000389) | 1.83109835 |
| 119 | Elevated erythrocyte sedimentation rate (HP:0003565) | 1.83034764 |
| 120 | Disinhibition (HP:0000734) | 1.81716980 |
| 121 | Upper limb muscle weakness (HP:0003484) | 1.81608266 |
| 122 | Epiphyseal dysplasia (HP:0002656) | 1.81300568 |
| 123 | Petechiae (HP:0000967) | 1.81181780 |
| 124 | Chest pain (HP:0100749) | 1.81022853 |
| 125 | Hypokalemic alkalosis (HP:0001949) | 1.80490220 |
| 126 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 1.80395808 |
| 127 | Abnormality of polysaccharide metabolism (HP:0011012) | 1.80395808 |
| 128 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 1.80395808 |
| 129 | Absent frontal sinuses (HP:0002688) | 1.80108206 |
| 130 | Emphysema (HP:0002097) | 1.79401796 |
| 131 | Ketoacidosis (HP:0001993) | 1.78923076 |
| 132 | Dysostosis multiplex (HP:0000943) | 1.78703805 |
| 133 | Villous atrophy (HP:0011473) | 1.78463921 |
| 134 | Abnormality of small intestinal villus morphology (HP:0011472) | 1.78463921 |
| 135 | Hepatitis (HP:0012115) | 1.78424260 |
| 136 | Gingival bleeding (HP:0000225) | 1.77880798 |
| 137 | Abnormality of the thoracic spine (HP:0100711) | 1.77835864 |
| 138 | Stomatitis (HP:0010280) | 1.76943842 |
| 139 | Submucous cleft hard palate (HP:0000176) | 1.75916278 |
| 140 | Ectopic kidney (HP:0000086) | 1.75562900 |
| 141 | Mitral stenosis (HP:0001718) | 1.73182680 |
| 142 | Onion bulb formation (HP:0003383) | 1.72280110 |
| 143 | Distal lower limb amyotrophy (HP:0008944) | 1.67176275 |
| 144 | Leukopenia (HP:0001882) | 1.66102800 |
| 145 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 1.64909642 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FRK | 4.23157168 |
| 2 | MAP3K14 | 3.69887713 |
| 3 | MAP4K1 | 2.97457561 |
| 4 | IRAK4 | 2.86790157 |
| 5 | RIPK4 | 2.75459799 |
| 6 | TGFBR2 | 2.73883137 |
| 7 | IRAK3 | 2.71610637 |
| 8 | SIK2 | 2.44509470 |
| 9 | MAP3K13 | 2.41511182 |
| 10 | KIT | 2.39889924 |
| 11 | CAMK1G | 2.37948479 |
| 12 | CAMK1D | 2.34537900 |
| 13 | TAOK3 | 2.23507144 |
| 14 | TYK2 | 2.16977461 |
| 15 | CSF1R | 2.07150604 |
| 16 | TBK1 | 1.97755896 |
| 17 | IKBKE | 1.85666222 |
| 18 | IKBKB | 1.80348685 |
| 19 | BMPR2 | 1.77087107 |
| 20 | BRD4 | 1.65689121 |
| 21 | JAK3 | 1.63362724 |
| 22 | JAK1 | 1.58755889 |
| 23 | SYK | 1.49257512 |
| 24 | CHUK | 1.48550792 |
| 25 | TRPM7 | 1.47695716 |
| 26 | HCK | 1.42477581 |
| 27 | CLK1 | 1.41748598 |
| 28 | CDK12 | 1.39478461 |
| 29 | ERN1 | 1.33771589 |
| 30 | FLT3 | 1.31940820 |
| 31 | MAPK15 | 1.30704620 |
| 32 | TXK | 1.29801493 |
| 33 | INSRR | 1.26567220 |
| 34 | PTK2B | 1.26528119 |
| 35 | ITK | 1.25176881 |
| 36 | BLK | 1.23360161 |
| 37 | BTK | 1.20295659 |
| 38 | CDC42BPA | 1.19610137 |
| 39 | EPHB1 | 1.14383963 |
| 40 | ERBB3 | 1.13521877 |
| 41 | TNK2 | 1.13370673 |
| 42 | NEK9 | 1.13144675 |
| 43 | SGK2 | 1.11943029 |
| 44 | FES | 1.05881723 |
| 45 | DAPK2 | 1.03440250 |
| 46 | GRK7 | 1.01063035 |
| 47 | PRPF4B | 1.00677231 |
| 48 | MAP2K3 | 1.00023890 |
| 49 | MAPK7 | 0.99547467 |
| 50 | PKN1 | 0.99540895 |
| 51 | FGFR3 | 0.98171490 |
| 52 | SGK3 | 0.96994722 |
| 53 | LYN | 0.96067585 |
| 54 | AKT3 | 0.94837274 |
| 55 | CSK | 0.94394902 |
| 56 | NLK | 0.93693662 |
| 57 | LCK | 0.93392721 |
| 58 | MAPK12 | 0.89218279 |
| 59 | JAK2 | 0.89008659 |
| 60 | IRAK1 | 0.88934072 |
| 61 | MAP3K10 | 0.87523434 |
| 62 | NTRK1 | 0.86409036 |
| 63 | ZAP70 | 0.86257931 |
| 64 | PTK6 | 0.85020691 |
| 65 | BMPR1B | 0.83291919 |
| 66 | GRK1 | 0.82165204 |
| 67 | TEC | 0.79584703 |
| 68 | SGK494 | 0.78107717 |
| 69 | SGK223 | 0.78107717 |
| 70 | PIK3CG | 0.77696533 |
| 71 | PRKCH | 0.77294238 |
| 72 | FGFR2 | 0.75631342 |
| 73 | ACVR1B | 0.74994805 |
| 74 | FGFR4 | 0.74370489 |
| 75 | STK10 | 0.73690125 |
| 76 | GRK6 | 0.72528990 |
| 77 | MAP2K6 | 0.71557993 |
| 78 | MAP3K7 | 0.70374516 |
| 79 | MELK | 0.68475698 |
| 80 | CDK9 | 0.67504890 |
| 81 | PRKAA2 | 0.66466918 |
| 82 | MAPK11 | 0.65056737 |
| 83 | WNK3 | 0.64730244 |
| 84 | FGR | 0.64492873 |
| 85 | MAPK13 | 0.64404441 |
| 86 | SGK1 | 0.63765656 |
| 87 | DYRK1B | 0.62880607 |
| 88 | MAP4K2 | 0.61900845 |
| 89 | NUAK1 | 0.60055769 |
| 90 | EGFR | 0.59759934 |
| 91 | CAMK4 | 0.59338076 |
| 92 | STK4 | 0.59221405 |
| 93 | PIM1 | 0.59146209 |
| 94 | PDK1 | 0.59114711 |
| 95 | YES1 | 0.57894564 |
| 96 | TAOK1 | 0.57161942 |
| 97 | PASK | 0.54998032 |
| 98 | STK3 | 0.53768921 |
| 99 | PRKCQ | 0.53516085 |
| 100 | EIF2AK2 | 0.51335509 |
| 101 | CAMKK2 | 0.49747505 |
| 102 | WNK1 | 0.49641861 |
| 103 | PDPK1 | 0.49223073 |
| 104 | MARK2 | 0.49136645 |
| 105 | MAP3K1 | 0.49092036 |
| 106 | TTN | 0.48679758 |
| 107 | CDK3 | 0.48474116 |
| 108 | MAP3K3 | 0.46195067 |
| 109 | ADRBK1 | 0.45631377 |
| 110 | STK11 | 0.45278250 |
| 111 | MATK | 0.45221125 |
| 112 | SIK3 | 0.45025121 |
| 113 | RPS6KA6 | 0.44576335 |
| 114 | MAPKAPK3 | 0.44480038 |
| 115 | IRAK2 | 0.44014955 |
| 116 | EPHA3 | 0.44004584 |
| 117 | OXSR1 | 0.43739825 |
| 118 | ADRBK2 | 0.43428551 |
| 119 | CCNB1 | 0.42479704 |
| 120 | MST4 | 0.42113680 |
| 121 | TGFBR1 | 0.41672338 |
| 122 | MARK3 | 0.41315032 |
| 123 | ABL1 | 0.41017641 |
| 124 | CAMKK1 | 0.40827331 |
| 125 | SIK1 | 0.40490043 |
| 126 | PKN2 | 0.40203947 |
| 127 | PRKD2 | 0.39874456 |
| 128 | HIPK2 | 0.39809247 |
| 129 | RPS6KA2 | 0.39228668 |
| 130 | TAOK2 | 0.36709006 |
| 131 | RPS6KC1 | 0.35624042 |
| 132 | LATS1 | 0.34345698 |
| 133 | INSR | 0.33338734 |
| 134 | FYN | 0.32604829 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 3.07345408 |
| 2 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 3.00458920 |
| 3 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.95209768 |
| 4 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.92858362 |
| 5 | Primary immunodeficiency_Homo sapiens_hsa05340 | 2.85178227 |
| 6 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.44343206 |
| 7 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.32351215 |
| 8 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 2.23959253 |
| 9 | Leishmaniasis_Homo sapiens_hsa05140 | 2.07239351 |
| 10 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 2.05329522 |
| 11 | Other glycan degradation_Homo sapiens_hsa00511 | 1.94954313 |
| 12 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.91629545 |
| 13 | Lysosome_Homo sapiens_hsa04142 | 1.83498770 |
| 14 | Tuberculosis_Homo sapiens_hsa05152 | 1.71774284 |
| 15 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.69007619 |
| 16 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.67923434 |
| 17 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.66968305 |
| 18 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.65248627 |
| 19 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.49601395 |
| 20 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.44639958 |
| 21 | Viral myocarditis_Homo sapiens_hsa05416 | 1.44474255 |
| 22 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.44390498 |
| 23 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.35399121 |
| 24 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.33622845 |
| 25 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.33500162 |
| 26 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.33263816 |
| 27 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.31292349 |
| 28 | Measles_Homo sapiens_hsa05162 | 1.29614598 |
| 29 | ABC transporters_Homo sapiens_hsa02010 | 1.29039751 |
| 30 | Malaria_Homo sapiens_hsa05144 | 1.22641357 |
| 31 | Lysine degradation_Homo sapiens_hsa00310 | 1.21339013 |
| 32 | Pertussis_Homo sapiens_hsa05133 | 1.21314816 |
| 33 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.20621627 |
| 34 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.20351150 |
| 35 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.18276172 |
| 36 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.16843839 |
| 37 | Apoptosis_Homo sapiens_hsa04210 | 1.15032258 |
| 38 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.14361131 |
| 39 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 1.13049159 |
| 40 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 1.11782697 |
| 41 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.07622522 |
| 42 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.07622180 |
| 43 | Influenza A_Homo sapiens_hsa05164 | 1.06144621 |
| 44 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.05221015 |
| 45 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.03365881 |
| 46 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.03159248 |
| 47 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.01263967 |
| 48 | Phagosome_Homo sapiens_hsa04145 | 0.98356369 |
| 49 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.96284667 |
| 50 | Hepatitis B_Homo sapiens_hsa05161 | 0.95528640 |
| 51 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.94208777 |
| 52 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.93890833 |
| 53 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.93636432 |
| 54 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.91049495 |
| 55 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.88131420 |
| 56 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.85345977 |
| 57 | Platelet activation_Homo sapiens_hsa04611 | 0.79876353 |
| 58 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.79493860 |
| 59 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.79182736 |
| 60 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.78605794 |
| 61 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.77314194 |
| 62 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.76481227 |
| 63 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.76157032 |
| 64 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.74136389 |
| 65 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.73955728 |
| 66 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.73091915 |
| 67 | Hepatitis C_Homo sapiens_hsa05160 | 0.72042415 |
| 68 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.71902459 |
| 69 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.70239842 |
| 70 | Asthma_Homo sapiens_hsa05310 | 0.69950406 |
| 71 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.67073861 |
| 72 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.66244368 |
| 73 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.65631942 |
| 74 | Insulin secretion_Homo sapiens_hsa04911 | 0.65469261 |
| 75 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.64329102 |
| 76 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.64214307 |
| 77 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.63929316 |
| 78 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.62257169 |
| 79 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.61705470 |
| 80 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.58787218 |
| 81 | Insulin resistance_Homo sapiens_hsa04931 | 0.58337138 |
| 82 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.58159110 |
| 83 | Circadian rhythm_Homo sapiens_hsa04710 | 0.57782384 |
| 84 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.56212177 |
| 85 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.55282553 |
| 86 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.54410492 |
| 87 | Legionellosis_Homo sapiens_hsa05134 | 0.54273989 |
| 88 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.53847377 |
| 89 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.52647257 |
| 90 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.52253726 |
| 91 | Endocytosis_Homo sapiens_hsa04144 | 0.52178600 |
| 92 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.50838510 |
| 93 | Shigellosis_Homo sapiens_hsa05131 | 0.50546619 |
| 94 | Olfactory transduction_Homo sapiens_hsa04740 | 0.50090116 |
| 95 | Salmonella infection_Homo sapiens_hsa05132 | 0.49257636 |
| 96 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.49017415 |
| 97 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.48985854 |
| 98 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.47913617 |
| 99 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.47554846 |
| 100 | Glioma_Homo sapiens_hsa05214 | 0.47333077 |
| 101 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.47321511 |
| 102 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.46907317 |
| 103 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.46728163 |
| 104 | Amoebiasis_Homo sapiens_hsa05146 | 0.44896350 |
| 105 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.44069875 |
| 106 | Allograft rejection_Homo sapiens_hsa05330 | 0.43252298 |
| 107 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.42622692 |
| 108 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.42449735 |
| 109 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.42151083 |
| 110 | Salivary secretion_Homo sapiens_hsa04970 | 0.41816106 |
| 111 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.41750445 |
| 112 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.40597555 |
| 113 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.40269057 |
| 114 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.38702356 |
| 115 | Renin secretion_Homo sapiens_hsa04924 | 0.37951003 |
| 116 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.37672773 |
| 117 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.37077963 |
| 118 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.36517036 |
| 119 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.36085593 |
| 120 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.35888431 |
| 121 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.35801670 |
| 122 | Mineral absorption_Homo sapiens_hsa04978 | 0.35405867 |
| 123 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.35223011 |
| 124 | Prostate cancer_Homo sapiens_hsa05215 | 0.34883435 |
| 125 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.34095939 |
| 126 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.33731849 |
| 127 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.33678243 |

