SNX3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like most family members. This protein interacts with phosphatidylinositol-3-phosphate, and is involved in protein trafficking. A pseudogene of this gene is present on the sex chromosomes. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.33905903
2proteasome assembly (GO:0043248)5.35051152
3formation of translation preinitiation complex (GO:0001731)4.49097712
4ribosomal small subunit assembly (GO:0000028)4.40826404
5negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.40271031
6neutrophil activation involved in immune response (GO:0002283)4.39911675
7negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)4.33898511
8maturation of SSU-rRNA (GO:0030490)4.21263188
9positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.16187041
10regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.11736643
11anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.08297424
12viral transcription (GO:0019083)4.05272745
13DNA strand elongation involved in DNA replication (GO:0006271)4.04228550
14negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.01406024
15negative regulation of ligase activity (GO:0051352)4.01406024
16purine nucleobase biosynthetic process (GO:0009113)3.99357093
17translational termination (GO:0006415)3.99183649
18regulation of cellular amino acid metabolic process (GO:0006521)3.96920488
19telomere maintenance via semi-conservative replication (GO:0032201)3.95113462
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.92531166
21nucleobase biosynthetic process (GO:0046112)3.84968602
22DNA strand elongation (GO:0022616)3.80106797
23deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.77788035
24antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.77552752
25translational elongation (GO:0006414)3.77439450
26extracellular fibril organization (GO:0043206)3.75819991
27cellular response to thyroid hormone stimulus (GO:0097067)3.71937827
28SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.71802387
29translational initiation (GO:0006413)3.71511114
30ribosomal small subunit biogenesis (GO:0042274)3.69227094
31positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.68849866
32DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.68786704
33cotranslational protein targeting to membrane (GO:0006613)3.61172045
34intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.60666272
35signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.60666272
36protein targeting to ER (GO:0045047)3.60572879
37signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.59477934
38signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.59477934
39signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.59477934
40positive regulation of ligase activity (GO:0051351)3.58970287
41folic acid metabolic process (GO:0046655)3.58941450
42DNA replication checkpoint (GO:0000076)3.58233325
43signal transduction involved in DNA integrity checkpoint (GO:0072401)3.50588474
44signal transduction involved in DNA damage checkpoint (GO:0072422)3.50588474
45protein localization to endoplasmic reticulum (GO:0070972)3.49480554
46protein deneddylation (GO:0000338)3.47860236
47folic acid transport (GO:0015884)3.45859316
48ribosomal large subunit biogenesis (GO:0042273)3.45333777
49Arp2/3 complex-mediated actin nucleation (GO:0034314)3.44725845
50fibril organization (GO:0097435)3.43974129
51translation (GO:0006412)3.43275178
52L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.43068631
53ribonucleoprotein complex biogenesis (GO:0022613)3.42078857
54establishment of protein localization to endoplasmic reticulum (GO:0072599)3.41589929
55ribosome biogenesis (GO:0042254)3.41427685
56signal transduction involved in cell cycle checkpoint (GO:0072395)3.41223470
57DNA replication initiation (GO:0006270)3.40437441
58regulation of mitochondrial translation (GO:0070129)3.39457465
59ribosome assembly (GO:0042255)3.36714744
60positive regulation of cellular amide metabolic process (GO:0034250)3.36484559
61telomere maintenance via recombination (GO:0000722)3.32069108
62nucleobase-containing small molecule interconversion (GO:0015949)3.30721300
63regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.29181323
64regulation of ubiquitin-protein transferase activity (GO:0051438)3.25679362
65cullin deneddylation (GO:0010388)3.25184066
66transcription elongation from RNA polymerase III promoter (GO:0006385)3.24776563
67termination of RNA polymerase III transcription (GO:0006386)3.24776563
68pseudouridine synthesis (GO:0001522)3.24368215
69cell cycle G1/S phase transition (GO:0044843)3.22948739
70G1/S transition of mitotic cell cycle (GO:0000082)3.22948739
71viral life cycle (GO:0019058)3.22431685
72GDP-mannose metabolic process (GO:0019673)3.21786735
73regulation of ligase activity (GO:0051340)3.19327385
74oxidative phosphorylation (GO:0006119)3.16893591
75rRNA modification (GO:0000154)3.15814037
76regulation of platelet aggregation (GO:0090330)3.15678645
77cellular protein complex disassembly (GO:0043624)3.14709865
78mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.13474343
79negative regulation of erythrocyte differentiation (GO:0045647)3.11534817
80iron-sulfur cluster assembly (GO:0016226)3.10900722
81metallo-sulfur cluster assembly (GO:0031163)3.10900722
82nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.09158434
83negative regulation of protein localization to plasma membrane (GO:1903077)3.08026131
84positive regulation of cell cycle arrest (GO:0071158)3.04152031
85thrombin receptor signaling pathway (GO:0070493)3.03928677
86adenosine receptor signaling pathway (GO:0001973)3.03904403
87rRNA processing (GO:0006364)3.03838241
88actin nucleation (GO:0045010)2.99173024
89positive regulation of receptor recycling (GO:0001921)2.98417616
90cyclooxygenase pathway (GO:0019371)2.96770137
91positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.96682744
92antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.96429503
932-deoxyribonucleotide biosynthetic process (GO:0009265)2.96097382
94deoxyribose phosphate biosynthetic process (GO:0046385)2.96097382
95pinocytosis (GO:0006907)2.95375890
96protein targeting to mitochondrion (GO:0006626)2.95370881
97establishment of protein localization to mitochondrion (GO:0072655)2.95346258
98spliceosomal snRNP assembly (GO:0000387)2.95254184
99endothelium development (GO:0003158)2.94822265
100heart process (GO:0003015)2.94664285
101heart contraction (GO:0060047)2.94664285
102platelet aggregation (GO:0070527)2.94579869
103response to thyroid hormone (GO:0097066)2.93325687
104L-methionine biosynthetic process (GO:0071265)2.92904476
105amino acid salvage (GO:0043102)2.92904476
106L-methionine salvage (GO:0071267)2.92904476
107regulation of platelet activation (GO:0010543)2.92477948
108protoporphyrinogen IX metabolic process (GO:0046501)2.91282579
109rRNA metabolic process (GO:0016072)2.89228848
110positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.88980943
111mitotic recombination (GO:0006312)2.86821783
112barbed-end actin filament capping (GO:0051016)2.86201314
113regulation of mast cell degranulation (GO:0043304)2.85967867
114response to peptidoglycan (GO:0032494)2.85486587
115guanosine-containing compound biosynthetic process (GO:1901070)2.83937568
116cellular component biogenesis (GO:0044085)2.83467930
117phagocytosis, engulfment (GO:0006911)2.82283341
118deoxyribonucleotide biosynthetic process (GO:0009263)2.81255428
119transcription-coupled nucleotide-excision repair (GO:0006283)2.80981106
120telomere maintenance via telomere lengthening (GO:0010833)2.80827239
121negative regulation of interleukin-17 production (GO:0032700)2.80069379
1227-methylguanosine mRNA capping (GO:0006370)2.78421839
123ATP synthesis coupled proton transport (GO:0015986)2.78181381
124energy coupled proton transport, down electrochemical gradient (GO:0015985)2.78181381
125positive regulation of lamellipodium assembly (GO:0010592)2.77279444
126regulation of cellular amine metabolic process (GO:0033238)2.76945517
127negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.76928998
128negative regulation of calcium ion transmembrane transport (GO:1903170)2.76928998
129galactose catabolic process (GO:0019388)2.76092325
130positive regulation of mast cell activation involved in immune response (GO:0033008)2.75751831
131positive regulation of mast cell degranulation (GO:0043306)2.75751831
132negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.74629638
133regulation of protein heterodimerization activity (GO:0043497)2.72977502
134nucleoside diphosphate biosynthetic process (GO:0009133)2.72658073
135regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.72074192
136protein localization to mitochondrion (GO:0070585)2.71988476
137DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.71589284
138cellular response to arsenic-containing substance (GO:0071243)2.70560896
139negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.70514692
140platelet degranulation (GO:0002576)2.69987790
141oxygen transport (GO:0015671)2.69153838
142regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.68898598
143regulation of amyloid precursor protein catabolic process (GO:1902991)2.65821519
144glycosphingolipid catabolic process (GO:0046479)2.64607002
145regulation of receptor recycling (GO:0001919)2.64528734
146lipoxygenase pathway (GO:0019372)2.64523266
147regulation of mast cell activation involved in immune response (GO:0033006)2.61838814
148negative regulation of homotypic cell-cell adhesion (GO:0034111)2.60554890
149gas transport (GO:0015669)2.57930101
150positive regulation of mast cell activation (GO:0033005)2.55904054
151regulation of integrin-mediated signaling pathway (GO:2001044)2.53559106
152regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.49976766
153peptide catabolic process (GO:0043171)2.49471394
154relaxation of smooth muscle (GO:0044557)2.47962353
155NADH metabolic process (GO:0006734)2.44180339
156G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.42027465
157regulation of leukocyte degranulation (GO:0043300)2.41423524
158glycolipid catabolic process (GO:0019377)2.40942264
159regulation of macrophage cytokine production (GO:0010935)2.40044421
160mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.38830866
161regulation of myeloid leukocyte mediated immunity (GO:0002886)2.38103385
162regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.37621116
163detection of molecule of bacterial origin (GO:0032490)2.37495673
164negative regulation of cation channel activity (GO:2001258)2.36822046
165positive regulation of leukocyte degranulation (GO:0043302)2.36364580
166angiogenesis involved in wound healing (GO:0060055)2.36212233
167positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)2.35535052
168blood coagulation, intrinsic pathway (GO:0007597)2.35325298
169protein localization to endosome (GO:0036010)2.33981909
170immunoglobulin mediated immune response (GO:0016064)2.31857236
171positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.29447624
172regulation of homotypic cell-cell adhesion (GO:0034110)2.28273973
173phagosome maturation (GO:0090382)2.26722799
174protoporphyrinogen IX biosynthetic process (GO:0006782)2.26499606
175positive regulation of macrophage cytokine production (GO:0060907)2.26112810
176mitochondrial calcium ion transport (GO:0006851)2.25969173
177negative regulation of heart rate (GO:0010459)2.24996417
178regulation of superoxide anion generation (GO:0032928)2.24422794
179detection of other organism (GO:0098543)2.24138789
180positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.24133375
181detection of external biotic stimulus (GO:0098581)2.24104968
182microglial cell activation (GO:0001774)2.23970781
183prostanoid biosynthetic process (GO:0046457)2.23404207
184prostaglandin biosynthetic process (GO:0001516)2.23404207
185positive regulation of B cell differentiation (GO:0045579)2.23314366
186mitochondrial calcium ion homeostasis (GO:0051560)2.22889392
187actin filament polymerization (GO:0030041)2.22279056
188purine nucleotide salvage (GO:0032261)2.21065014
189triglyceride catabolic process (GO:0019433)2.21002751
190negative regulation of heart contraction (GO:0045822)2.18617312
191regulation of metalloenzyme activity (GO:0048552)2.18395997
192neutrophil activation (GO:0042119)2.17669660
193positive regulation of hemostasis (GO:1900048)2.17303462
194positive regulation of blood coagulation (GO:0030194)2.17303462
195cellular response to epinephrine stimulus (GO:0071872)2.16274326
196modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.15415021

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.44130520
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.11000896
3E2F7_22180533_ChIP-Seq_HELA_Human4.03452595
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.78143738
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.20458630
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.13944380
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.10635324
8* ETS1_20019798_ChIP-Seq_JURKAT_Human3.00460608
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.94315032
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.89234265
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.86358722
12SCL_19346495_ChIP-Seq_HPC-7_Human2.86193217
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.84103500
14* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.72021446
15* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.55368532
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.54437093
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.44485478
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.43982058
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.43714348
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.42591213
21IRF8_22096565_ChIP-ChIP_GC-B_Human2.24089227
22XRN2_22483619_ChIP-Seq_HELA_Human2.20906059
23CLOCK_20551151_ChIP-Seq_293T_Human2.17960136
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.16437012
25VDR_23849224_ChIP-Seq_CD4+_Human2.16333024
26IRF8_27001747_Chip-Seq_BMDM_Mouse2.14521604
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.14204213
28DCP1A_22483619_ChIP-Seq_HELA_Human2.12200116
29NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08346772
30TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.07535726
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.07488052
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.06843517
33LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.05690986
34SPI1_23127762_ChIP-Seq_K562_Human2.04289450
35LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.03114232
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.02804188
37* GABP_19822575_ChIP-Seq_HepG2_Human2.00116783
38GATA1_19941826_ChIP-Seq_K562_Human1.99629301
39ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.88609576
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.86975918
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.85981425
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.85849007
43* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.85227861
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.85100619
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.84164249
46FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.83185504
47GATA2_21666600_ChIP-Seq_HMVEC_Human1.83088949
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.80375542
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.74913975
50* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.72876426
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.71759410
52FOXM1_23109430_ChIP-Seq_U2OS_Human1.71756421
53FOXP3_21729870_ChIP-Seq_TREG_Human1.69961657
54* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.69210010
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.68083930
56VDR_24763502_ChIP-Seq_THP-1_Human1.66901074
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.66301389
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.66081190
59TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.64926132
60GATA2_22383799_ChIP-Seq_G1ME_Mouse1.63732176
61* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.63442156
62CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.63036930
63* GATA1_19941827_ChIP-Seq_MEL_Mouse1.62699571
64* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61395545
65* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.60679092
66AR_21909140_ChIP-Seq_LNCAP_Human1.60506087
67E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.58370169
68NANOG_18555785_ChIP-Seq_MESCs_Mouse1.55980299
69* TTF2_22483619_ChIP-Seq_HELA_Human1.55880103
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.53410520
71FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50126915
72* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.48769298
73MYCN_18555785_ChIP-Seq_MESCs_Mouse1.48544919
74EGR1_19374776_ChIP-ChIP_THP-1_Human1.48314021
75PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48296943
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.47839897
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47838624
78TRIM28_21343339_ChIP-Seq_HEK293_Human1.45605422
79GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.44142253
80GATA2_19941826_ChIP-Seq_K562_Human1.42457726
81TFEB_21752829_ChIP-Seq_HELA_Human1.38875476
82HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38052845
83STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37353787
84POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36802244
85PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.33547472
86GATA1_22025678_ChIP-Seq_K562_Human1.33373467
87SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.33081943
88MYC_22102868_ChIP-Seq_BL_Human1.32851767
89PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.32632698
90KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32608070
91GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32383002
92ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32360182
93NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.31970008
94CIITA_25753668_ChIP-Seq_RAJI_Human1.30392420
95SALL4_18804426_ChIP-ChIP_XEN_Mouse1.30353963
96CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.30150659
97STAT4_19710469_ChIP-ChIP_TH1__Mouse1.29073088
98WT1_19549856_ChIP-ChIP_CCG9911_Human1.28584507
99* SPI1_23547873_ChIP-Seq_NB4_Human1.27881739
100PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27265404
101RXR_22158963_ChIP-Seq_LIVER_Mouse1.26690645
102NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.26290903
103KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.25880944
104POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.23698287
105MYB_21317192_ChIP-Seq_ERMYB_Mouse1.22923480
106SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22387486
107ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22342325
108ELK1_19687146_ChIP-ChIP_HELA_Human1.22313901
109ELK1_22589737_ChIP-Seq_MCF10A_Human1.21758655
110SRY_22984422_ChIP-ChIP_TESTIS_Rat1.21122619
111VDR_21846776_ChIP-Seq_THP-1_Human1.20801958
112PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20629543
113ZNF263_19887448_ChIP-Seq_K562_Human1.19920384
114CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19098762
115* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17649780
116RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.16945331
117KDM5A_27292631_Chip-Seq_BREAST_Human1.16770242
118VDR_24787735_ChIP-Seq_THP-1_Human1.15388138
119ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14139188
120MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14130224
121E2F1_21310950_ChIP-Seq_MCF-7_Human1.13089535
122DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12138556
123NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11553083
124NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11553083
125* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11363491
126NCOR1_26117541_ChIP-Seq_K562_Human1.10535695
127PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09790031
128IRF8_21731497_ChIP-ChIP_J774_Mouse1.08607518
129RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05935249
130LXR_22292898_ChIP-Seq_THP-1_Human1.05930157
131IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05470906
132* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.05403636
133SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05120883
134GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04954809
135CTCF_18555785_ChIP-Seq_MESCs_Mouse1.04828507
136CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04546969
137ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.04523451
138STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.04328838
139E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03933338
140CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02828772
141TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00553770
142SMAD_19615063_ChIP-ChIP_OVARY_Human0.98755800
143SMC1_22415368_ChIP-Seq_MEFs_Mouse0.98553242
144GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98439518
145* PU_27001747_Chip-Seq_BMDM_Mouse0.97751245
146NOTCH1_21737748_ChIP-Seq_TLL_Human0.97459782
147ELK3_25401928_ChIP-Seq_HUVEC_Human0.96891217
148IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.96774631
149CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95572293
150PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.95036333
151CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94761277
152FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.94442770
153RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93776818
154ATF3_27146783_Chip-Seq_COLON_Human0.93559732
155TBX5_21415370_ChIP-Seq_HL-1_Mouse0.93527347
156* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93521581
157TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.93127389
158TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92858966
159OCT4_18692474_ChIP-Seq_MEFs_Mouse0.92822646
160FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.92004060
161FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.90724012
162TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.88966495
163SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88915994
164NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.88874879
165* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88796134
166* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88660586
167PPARA_22158963_ChIP-Seq_LIVER_Mouse0.88134531
168FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.88070357
169RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87678171
170* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87373697
171SPI1_20517297_ChIP-Seq_HL60_Human0.85516040
172PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85133953
173SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84865033

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.90999276
2MP0004957_abnormal_blastocyst_morpholog3.76152195
3MP0003111_abnormal_nucleus_morphology2.88785594
4MP0009840_abnormal_foam_cell2.82484406
5MP0009333_abnormal_splenocyte_physiolog2.68356294
6MP0003186_abnormal_redox_activity2.58686324
7MP0003077_abnormal_cell_cycle2.55201564
8MP0008438_abnormal_cutaneous_collagen2.54106478
9MP0008007_abnormal_cellular_replicative2.31719461
10MP0010094_abnormal_chromosome_stability2.28566139
11MP0005451_abnormal_body_composition2.27899120
12MP0003172_abnormal_lysosome_physiology2.24171729
13MP0006054_spinal_hemorrhage2.23438257
14MP0001545_abnormal_hematopoietic_system2.21105460
15MP0005397_hematopoietic_system_phenotyp2.21105460
16MP0005058_abnormal_lysosome_morphology2.16623838
17MP0003191_abnormal_cellular_cholesterol2.14564856
18MP0008004_abnormal_stomach_pH2.11992120
19MP0002877_abnormal_melanocyte_morpholog2.07317510
20MP0004147_increased_porphyrin_level2.04384859
21MP0000490_abnormal_crypts_of2.02058602
22MP0002396_abnormal_hematopoietic_system1.94466620
23MP0003656_abnormal_erythrocyte_physiolo1.92586384
24MP0003724_increased_susceptibility_to1.92359162
25MP0003075_altered_response_to1.91779282
26MP0008932_abnormal_embryonic_tissue1.88894741
27MP0006036_abnormal_mitochondrial_physio1.86432841
28MP0003300_gastrointestinal_ulcer1.70862821
29MP0003279_aneurysm1.70596694
30MP0003806_abnormal_nucleotide_metabolis1.68763233
31MP0003221_abnormal_cardiomyocyte_apopto1.67548854
32MP0005670_abnormal_white_adipose1.66148565
33MP0001730_embryonic_growth_arrest1.63900941
34MP0000358_abnormal_cell_content/1.59802628
35MP0003786_premature_aging1.59520620
36MP0009785_altered_susceptibility_to1.59052658
37MP0004036_abnormal_muscle_relaxation1.56118107
38MP0001958_emphysema1.51958362
39MP0003436_decreased_susceptibility_to1.51773849
40MP0008260_abnormal_autophagy1.47617463
41MP0000343_altered_response_to1.45639085
42MP0001835_abnormal_antigen_presentation1.43796589
43MP0008058_abnormal_DNA_repair1.43491508
44MP0010368_abnormal_lymphatic_system1.42102092
45MP0001853_heart_inflammation1.40058151
46MP0010352_gastrointestinal_tract_polyps1.40036385
47MP0000858_altered_metastatic_potential1.39886097
48MP0002148_abnormal_hypersensitivity_rea1.36791594
49MP0003828_pulmonary_edema1.35408976
50MP0004084_abnormal_cardiac_muscle1.35096995
51MP0005166_decreased_susceptibility_to1.33782462
52MP0003718_maternal_effect1.32966205
53MP0008874_decreased_physiological_sensi1.32863463
54MP0000350_abnormal_cell_proliferation1.32010799
55MP0005666_abnormal_adipose_tissue1.31421429
56MP0001851_eye_inflammation1.30767323
57MP0004510_myositis1.30344195
58MP0002722_abnormal_immune_system1.28976686
59MP0000750_abnormal_muscle_regeneration1.27355197
60MP0003646_muscle_fatigue1.27213269
61MP0001542_abnormal_bone_strength1.26824060
62MP0000689_abnormal_spleen_morphology1.26248197
63MP0002398_abnormal_bone_marrow1.26042441
64MP0009763_increased_sensitivity_to1.23902123
65MP0000751_myopathy1.23018057
66MP0005025_abnormal_response_to1.22374090
67MP0002080_prenatal_lethality1.22015210
68MP0002019_abnormal_tumor_incidence1.21751249
69MP0000313_abnormal_cell_death1.21562226
70MP0004272_abnormal_basement_membrane1.20719370
71MP0005671_abnormal_response_to1.20427781
72MP0000013_abnormal_adipose_tissue1.20407914
73MP0005000_abnormal_immune_tolerance1.19604535
74MP0005275_abnormal_skin_tensile1.19112698
75MP0004484_altered_response_of1.18017578
76MP0002429_abnormal_blood_cell1.16419219
77MP0010307_abnormal_tumor_latency1.15956404
78MP0004808_abnormal_hematopoietic_stem1.13731454
79MP0000685_abnormal_immune_system1.13661221
80MP0006035_abnormal_mitochondrial_morpho1.13584283
81MP0003123_paternal_imprinting1.12757144
82MP0003690_abnormal_glial_cell1.12492729
83MP0002419_abnormal_innate_immunity1.12409957
84MP0005167_abnormal_blood-brain_barrier1.12246868
85MP0000604_amyloidosis1.11127108
86MP0002132_abnormal_respiratory_system1.10811787
87MP0002405_respiratory_system_inflammati1.10690093
88MP0002972_abnormal_cardiac_muscle1.09644799
89MP0002420_abnormal_adaptive_immunity1.09557686
90MP0009764_decreased_sensitivity_to1.09555194
91MP0001819_abnormal_immune_cell1.08973366
92MP0001697_abnormal_embryo_size1.08677844
93MP0000465_gastrointestinal_hemorrhage1.08282295
94MP0009379_abnormal_foot_pigmentation1.08261956
95MP0003567_abnormal_fetal_cardiomyocyte1.08015102
96MP0001879_abnormal_lymphatic_vessel1.06792091
97MP0002452_abnormal_antigen_presenting1.06624167
98MP0003763_abnormal_thymus_physiology1.04712865
99MP0001533_abnormal_skeleton_physiology1.03623949
100MP0003329_amyloid_beta_deposits1.03510968
101MP0000249_abnormal_blood_vessel1.02378801
102MP0000716_abnormal_immune_system1.02313055
103MP0000747_muscle_weakness1.00307999
104MP0002723_abnormal_immune_serum0.99396868
105MP0005584_abnormal_enzyme/coenzyme_acti0.99331656
106MP0002971_abnormal_brown_adipose0.97854405
107MP0008057_abnormal_DNA_replication0.97748096
108MP0005084_abnormal_gallbladder_morpholo0.96097094
109MP0003303_peritoneal_inflammation0.96016699
110MP0000920_abnormal_myelination0.94155825
111MP0005164_abnormal_response_to0.93720100
112MP0008469_abnormal_protein_level0.92862815
113MP0006138_congestive_heart_failure0.92507310
114MP0005330_cardiomyopathy0.92088507
115MP0003566_abnormal_cell_adhesion0.91286094
116MP0000015_abnormal_ear_pigmentation0.90991861
117MP0005535_abnormal_body_temperature0.90969957
118MP0005464_abnormal_platelet_physiology0.90958394
119MP0001845_abnormal_inflammatory_respons0.89581597
120MP0003984_embryonic_growth_retardation0.88301648
121MP0001544_abnormal_cardiovascular_syste0.87742463
122MP0005385_cardiovascular_system_phenoty0.87742463
123MP0000681_abnormal_thyroid_gland0.87444800
124MP0005023_abnormal_wound_healing0.86923102
125MP0000749_muscle_degeneration0.86361978
126MP0002332_abnormal_exercise_endurance0.86019636
127MP0009765_abnormal_xenobiotic_induced0.85970946
128MP0000703_abnormal_thymus_morphology0.85709830
129MP0002088_abnormal_embryonic_growth/wei0.85614776
130MP0005375_adipose_tissue_phenotype0.84875553
131MP0005380_embryogenesis_phenotype0.84826688
132MP0001672_abnormal_embryogenesis/_devel0.84826688
133MP0005165_increased_susceptibility_to0.84750333
134MP0004859_abnormal_synaptic_plasticity0.84395352
135MP0005636_abnormal_mineral_homeostasis0.84166725
136MP0003091_abnormal_cell_migration0.84028293
137MP0009643_abnormal_urine_homeostasis0.81655801
138MP0003448_altered_tumor_morphology0.81646292
139MP0001756_abnormal_urination0.81638803
140MP0000759_abnormal_skeletal_muscle0.81314213
141MP0005623_abnormal_meninges_morphology0.81161438
142MP0002086_abnormal_extraembryonic_tissu0.81151101
143MP0004130_abnormal_muscle_cell0.79547907
144MP0002998_abnormal_bone_remodeling0.78848755
145MP0004215_abnormal_myocardial_fiber0.78720186
146MP0001800_abnormal_humoral_immune0.77655449
147MP0005620_abnormal_muscle_contractility0.77517875
148MP0009278_abnormal_bone_marrow0.77352745
149MP0005384_cellular_phenotype0.76709447
150MP0004087_abnormal_muscle_fiber0.75367808
151MP0005319_abnormal_enzyme/_coenzyme0.73143876
152MP0004947_skin_inflammation0.72954080
153MP0005075_abnormal_melanosome_morpholog0.72832359
154MP0006082_CNS_inflammation0.72330668
155MP0004145_abnormal_muscle_electrophysio0.71416003

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)4.88959561
2Abnormality of cells of the erythroid lineage (HP:0012130)4.79644753
3Prolonged bleeding time (HP:0003010)4.54720545
4Purpura (HP:0000979)4.46146933
5Increased mean platelet volume (HP:0011877)4.14791370
6Decreased activity of mitochondrial respiratory chain (HP:0008972)4.08979470
7Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.08979470
8Abnormal platelet volume (HP:0011876)3.98565475
9Epistaxis (HP:0000421)3.69351730
10Poor head control (HP:0002421)3.47463193
11Menorrhagia (HP:0000132)3.44598852
12Gingival bleeding (HP:0000225)3.43495662
13Reticulocytopenia (HP:0001896)3.40531020
14Breast hypoplasia (HP:0003187)3.38159639
15Progressive muscle weakness (HP:0003323)3.37654893
16Birth length less than 3rd percentile (HP:0003561)3.36967109
17Abnormality of alanine metabolism (HP:0010916)3.30675033
18Hyperalaninemia (HP:0003348)3.30675033
19Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.30675033
20Multiple enchondromatosis (HP:0005701)3.17692616
21Carpal bone hypoplasia (HP:0001498)3.15099690
22Hepatosplenomegaly (HP:0001433)3.07678148
23Cerebral hypomyelination (HP:0006808)3.03814511
24Hepatic necrosis (HP:0002605)3.01064875
25Hepatocellular necrosis (HP:0001404)2.96293651
26Rough bone trabeculation (HP:0100670)2.93170374
27Macrocytic anemia (HP:0001972)2.91507064
28Microretrognathia (HP:0000308)2.90848899
29Abnormality of skeletal muscle fiber size (HP:0012084)2.85123263
30Trismus (HP:0000211)2.83733987
31Petechiae (HP:0000967)2.83652896
32Increased serum lactate (HP:0002151)2.83242645
33Obstructive lung disease (HP:0006536)2.83053262
34Chronic obstructive pulmonary disease (HP:0006510)2.83053262
35Degeneration of anterior horn cells (HP:0002398)2.79584163
36Abnormality of the anterior horn cell (HP:0006802)2.79584163
37Systemic lupus erythematosus (HP:0002725)2.71155066
38Axonal loss (HP:0003447)2.70973985
39Aplastic anemia (HP:0001915)2.69643628
40Abnormal platelet function (HP:0011869)2.67486217
41Impaired platelet aggregation (HP:0003540)2.67486217
42Oral leukoplakia (HP:0002745)2.66576014
43Abnormality of the vasculature of the conjunctiva (HP:0008054)2.65853968
44Increased variability in muscle fiber diameter (HP:0003557)2.65008519
45Vacuolated lymphocytes (HP:0001922)2.64309406
46Increased CSF lactate (HP:0002490)2.61971323
47Mitochondrial inheritance (HP:0001427)2.61422672
48Nausea (HP:0002018)2.61111937
49Pallor (HP:0000980)2.60196780
50Nemaline bodies (HP:0003798)2.59991493
51Muscle fiber splitting (HP:0003555)2.57226965
52Increased cerebral lipofuscin (HP:0011813)2.55614631
53Abnormality of the heme biosynthetic pathway (HP:0010472)2.51817916
54Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.51741667
55Conjunctival telangiectasia (HP:0000524)2.51015132
56Type I transferrin isoform profile (HP:0003642)2.50931235
57Abnormal mitochondria in muscle tissue (HP:0008316)2.48877258
58Increased neuronal autofluorescent lipopigment (HP:0002074)2.46721081
59Personality changes (HP:0000751)2.44296805
60Exertional dyspnea (HP:0002875)2.43886564
61Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.41927710
62Acute necrotizing encephalopathy (HP:0006965)2.39805875
63Amyloidosis (HP:0011034)2.38849439
64Muscle fiber inclusion bodies (HP:0100299)2.38827174
65Increased intramyocellular lipid droplets (HP:0012240)2.38701507
66Lactic acidosis (HP:0003128)2.38007039
67Distal lower limb muscle weakness (HP:0009053)2.37085321
68Sparse eyelashes (HP:0000653)2.35980463
69Polycythemia (HP:0001901)2.35027913
70Abnormality of the umbilical cord (HP:0010881)2.34444744
71Death in infancy (HP:0001522)2.30584671
72Vertebral compression fractures (HP:0002953)2.29783211
73Increased hepatocellular lipid droplets (HP:0006565)2.29703852
74Abnormal hemoglobin (HP:0011902)2.28732033
75Increased muscle lipid content (HP:0009058)2.28507676
76Abnormality of macrophages (HP:0004311)2.28494235
77Type 1 muscle fiber predominance (HP:0003803)2.26646101
78Dysostosis multiplex (HP:0000943)2.24542927
79Spontaneous hematomas (HP:0007420)2.24385332
80Patent foramen ovale (HP:0001655)2.24109919
81Elevated erythrocyte sedimentation rate (HP:0003565)2.22526842
82CNS demyelination (HP:0007305)2.22344205
83Abnormal protein glycosylation (HP:0012346)2.20405330
84Abnormal glycosylation (HP:0012345)2.20405330
85Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.20405330
86Abnormal protein N-linked glycosylation (HP:0012347)2.20405330
87Increased serum ferritin (HP:0003281)2.19767896
88Exercise-induced myalgia (HP:0003738)2.19059340
89Centrally nucleated skeletal muscle fibers (HP:0003687)2.18960669
90Lipid accumulation in hepatocytes (HP:0006561)2.18586581
91Myocardial infarction (HP:0001658)2.17065814
923-Methylglutaconic aciduria (HP:0003535)2.16878626
93Recurrent abscess formation (HP:0002722)2.16738207
94Myoglobinuria (HP:0002913)2.15257733
95Paralysis (HP:0003470)2.13295847
96Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.11698350
97Nonimmune hydrops fetalis (HP:0001790)2.11472131
98Reduced antithrombin III activity (HP:0001976)2.11270754
99Abnormality of glycolipid metabolism (HP:0010969)2.09851225
100Abnormality of liposaccharide metabolism (HP:0010968)2.09851225
101Abnormality of glycosphingolipid metabolism (HP:0004343)2.09851225
102Respiratory difficulties (HP:0002880)2.09832891
103IgM deficiency (HP:0002850)2.09369456
104Respiratory failure (HP:0002878)2.08572106
105Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.08328331
106Poikilocytosis (HP:0004447)2.08285937
107Exercise intolerance (HP:0003546)2.08039747
108Protrusio acetabuli (HP:0003179)2.07296434
109Postnatal microcephaly (HP:0005484)2.07039742
110Cerebral hemorrhage (HP:0001342)2.07000849
111Premature rupture of membranes (HP:0001788)2.06341576
112Aplasia/Hypoplasia of the sacrum (HP:0008517)2.06153457
113Eczematoid dermatitis (HP:0000976)2.06096768
114Slender long bone (HP:0003100)2.05649356
115Atrophy/Degeneration involving motor neurons (HP:0007373)2.05486830
116Hyperlipoproteinemia (HP:0010980)2.05110910
117Premature ovarian failure (HP:0008209)2.02689612
118Scanning speech (HP:0002168)2.01740122
119Hyporeflexia of lower limbs (HP:0002600)1.99887458
120Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.99509069
121Recurrent bacterial skin infections (HP:0005406)1.99271307
122Abnormal trabecular bone morphology (HP:0100671)1.95794944
123EMG: myopathic abnormalities (HP:0003458)1.95061285
124Emotional lability (HP:0000712)1.93041293
125Acute encephalopathy (HP:0006846)1.92111107
126Reticulocytosis (HP:0001923)1.92041958
127Thrombocytosis (HP:0001894)1.91916367
128Reduced subcutaneous adipose tissue (HP:0003758)1.91655204
129Ragged-red muscle fibers (HP:0003200)1.91621942
130Cholecystitis (HP:0001082)1.90450801
131Abnormal gallbladder physiology (HP:0012438)1.90450801
132Loss of speech (HP:0002371)1.89810907
133Muscle stiffness (HP:0003552)1.89505889
134Esophageal neoplasm (HP:0100751)1.89112837
135Neoplasm of head and neck (HP:0012288)1.89112837
136Cerebral inclusion bodies (HP:0100314)1.88738125
137Megaloblastic anemia (HP:0001889)1.87456857
138Cellulitis (HP:0100658)1.87215807
139Fatigue (HP:0012378)1.86338932
140Abnormality of glycolysis (HP:0004366)1.86003697
141Increased serum pyruvate (HP:0003542)1.86003697
142Abnormality of reticulocytes (HP:0004312)1.85069066
143Secondary amenorrhea (HP:0000869)1.84715337
144Rhabdomyolysis (HP:0003201)1.84646798
145Generalized aminoaciduria (HP:0002909)1.83958060
146Mutism (HP:0002300)1.83520017
147Progressive neurologic deterioration (HP:0002344)1.83429965
148Cholelithiasis (HP:0001081)1.83234383
149Pustule (HP:0200039)1.82139794
150Delusions (HP:0000746)1.81460862
151Unsteady gait (HP:0002317)1.80727137
152CNS hypomyelination (HP:0003429)1.80423139
153Pancytopenia (HP:0001876)1.80250636
154Abnormality of the tricuspid valve (HP:0001702)1.79386771
155Diplopia (HP:0000651)1.79380207
156Abnormality of binocular vision (HP:0011514)1.79380207
157Muscle fiber atrophy (HP:0100295)1.79038740
158Tetraparesis (HP:0002273)1.78469933
159Asymmetric septal hypertrophy (HP:0001670)1.77697710
160Episodic fever (HP:0001954)1.76523134
161Bruising susceptibility (HP:0000978)1.76128603
162Foot dorsiflexor weakness (HP:0009027)1.75927458
163Abnormality of complement system (HP:0005339)1.75194325
164Abnormality of the foot musculature (HP:0001436)1.74861819
165Hypertensive crisis (HP:0100735)1.74805993
166Mucosal telangiectasiae (HP:0100579)1.71916468
167Hemorrhage of the eye (HP:0011885)1.71688260
168Neurofibrillary tangles (HP:0002185)1.69928734
169Spinal rigidity (HP:0003306)1.69773062
170Increased connective tissue (HP:0009025)1.67197770
171Distal lower limb amyotrophy (HP:0008944)1.66167787
172Acanthocytosis (HP:0001927)1.65695285
173Neck muscle weakness (HP:0000467)1.64955810
174Abnormal gallbladder morphology (HP:0012437)1.62953372
175Chest pain (HP:0100749)1.62826376
176Peritonitis (HP:0002586)1.61856629
177Abnormality of lateral ventricle (HP:0030047)1.61406536
178Diminished motivation (HP:0000745)1.60104386
179Thrombophlebitis (HP:0004418)1.59962659

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.68796574
2NME24.27225722
3WEE13.82612854
4STK163.33287872
5RIPK43.18244084
6TESK23.08281674
7EIF2AK13.06436656
8KDR2.90486179
9PIM22.71544049
10BMPR22.45356121
11ACVR1B2.37679989
12TESK12.34907038
13NEK12.23940549
14MAP3K112.06986891
15SCYL21.98063828
16PIK3CG1.96701446
17EPHA21.94287112
18MAP3K131.80379960
19BRSK21.78762599
20TRIB31.75984375
21EIF2AK31.65644437
22PLK41.60226438
23RPS6KA41.59616398
24NEK21.59137859
25BCKDK1.58140017
26FES1.55963427
27MST41.55124851
28DYRK31.48081635
29ARAF1.47627082
30PRPF4B1.46832193
31TSSK61.42477062
32MAP3K61.38261373
33TTN1.37384751
34BLK1.34989854
35LIMK11.33800308
36LRRK21.31063319
37MAP3K121.29931580
38PAK41.28070601
39MAPKAPK31.24157596
40ERN11.24057897
41MAPK121.20161234
42KSR21.19704227
43MAP3K11.18605924
44BRSK11.17007348
45MAP4K11.15408257
46ZAP701.14936954
47NTRK11.14433815
48TBK11.11258959
49ILK1.08798200
50SYK1.04584575
51NME11.01801870
52CSF1R1.01732761
53VRK11.01701440
54PLK11.01530291
55MAP3K81.01190795
56AURKA1.00155991
57IRAK31.00055589
58PKN20.99257384
59BRAF0.97874943
60ABL20.95265086
61TAOK30.95165908
62MAP3K140.94949966
63BMX0.94269696
64GRK50.92879063
65FLT30.92475874
66OBSCN0.92462082
67CAMKK20.92185245
68PAK60.91924682
69MATK0.91665199
70PDK30.90772017
71PDK40.90772017
72MAP2K30.90324868
73NEK90.89403730
74CCNB10.88748410
75PDK20.87570634
76RPS6KB20.85673057
77TTK0.83711616
78CDK70.83217200
79TAOK20.82563966
80PAK10.81999099
81SRPK10.80383921
82CDC70.79543318
83ROCK20.78508316
84AURKB0.78331116
85TLK10.78217854
86PTK2B0.77920870
87CSK0.76485021
88CAMK2G0.76168358
89MAP3K30.75935439
90DMPK0.74872643
91TGFBR10.74515095
92LATS20.73917960
93TAOK10.73140769
94TRPM70.72587769
95MAP2K40.72543959
96STK100.71470774
97FGR0.69878111
98CDK190.69772263
99PDPK10.67924570
100LYN0.64685971
101PINK10.63574805
102MYLK0.63462127
103JAK20.62485468
104MAP3K50.62474242
105PLK20.62006627
106TIE10.61088941
107CDK60.59617687
108HCK0.59174649
109DAPK30.57305507
110DDR20.56853461
111RIPK10.56789624
112TYK20.56615221
113RAF10.56149893
114PRKD10.55866495
115JAK10.55522025
116PRKG20.55116922
117PIM10.54993207
118KIT0.54722200
119PAK20.54502770
120ERBB30.53543464
121DAPK10.53281102
122MAP2K20.52973484
123JAK30.52600689
124STK40.52501035
125CAMK2B0.50553211
126EPHA30.49561520
127DAPK20.49045758
128CDK40.47859709
129CAMK2D0.46397235
130CSNK2A10.45717391
131PDK10.44748317
132MAPK40.44133831
133STK240.43835696
134ROCK10.42528852
135PRKCI0.41987049
136CDK11A0.41731029
137MARK30.40186179
138BTK0.37773111
139CHEK20.36030450
140PLK30.33549439
141PBK0.32380169
142TEC0.31223295
143CDK140.31222885
144ZAK0.29359236
145CDK80.29351564
146GRK60.29275946
147CSNK2A20.28535726
148MAPKAPK20.28041830
149IKBKB0.26079201
150MOS0.24652849
151DYRK20.24594715
152MAP2K60.24506077

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.04466474
2DNA replication_Homo sapiens_hsa030304.25193128
3Ribosome_Homo sapiens_hsa030104.11004820
4RNA polymerase_Homo sapiens_hsa030203.34253819
5Asthma_Homo sapiens_hsa053102.83960727
6Mismatch repair_Homo sapiens_hsa034302.80123155
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.55616455
8Pyrimidine metabolism_Homo sapiens_hsa002402.52499054
9Base excision repair_Homo sapiens_hsa034102.34151450
10Staphylococcus aureus infection_Homo sapiens_hsa051502.21378344
11Nucleotide excision repair_Homo sapiens_hsa034202.20303925
12Spliceosome_Homo sapiens_hsa030402.19765424
13RNA transport_Homo sapiens_hsa030132.17017485
14Platelet activation_Homo sapiens_hsa046112.07571628
15Allograft rejection_Homo sapiens_hsa053302.07509919
16Pentose phosphate pathway_Homo sapiens_hsa000301.96501046
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.96007446
18Folate biosynthesis_Homo sapiens_hsa007901.94347908
19Oxidative phosphorylation_Homo sapiens_hsa001901.93486754
20Fatty acid elongation_Homo sapiens_hsa000621.91801900
21Parkinsons disease_Homo sapiens_hsa050121.88284243
22Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.87864223
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.86181973
24Homologous recombination_Homo sapiens_hsa034401.85758957
25Sulfur relay system_Homo sapiens_hsa041221.74637548
26Viral myocarditis_Homo sapiens_hsa054161.74421446
27Cell cycle_Homo sapiens_hsa041101.73311957
28Autoimmune thyroid disease_Homo sapiens_hsa053201.73214376
29Graft-versus-host disease_Homo sapiens_hsa053321.72487990
30Protein export_Homo sapiens_hsa030601.69862111
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.62294394
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.57128047
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.55421063
34Huntingtons disease_Homo sapiens_hsa050161.45036577
35Toxoplasmosis_Homo sapiens_hsa051451.44792308
36Type I diabetes mellitus_Homo sapiens_hsa049401.41996694
37Legionellosis_Homo sapiens_hsa051341.34817752
38Purine metabolism_Homo sapiens_hsa002301.33500808
39p53 signaling pathway_Homo sapiens_hsa041151.27675331
40Synaptic vesicle cycle_Homo sapiens_hsa047211.24559987
41Lysosome_Homo sapiens_hsa041421.24211277
42Vitamin B6 metabolism_Homo sapiens_hsa007501.23122957
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.22401777
44Osteoclast differentiation_Homo sapiens_hsa043801.21101738
45Amoebiasis_Homo sapiens_hsa051461.21036576
46Toll-like receptor signaling pathway_Homo sapiens_hsa046201.20398492
47Fructose and mannose metabolism_Homo sapiens_hsa000511.17727741
48Epstein-Barr virus infection_Homo sapiens_hsa051691.17250643
49Intestinal immune network for IgA production_Homo sapiens_hsa046721.16584715
50Regulation of autophagy_Homo sapiens_hsa041401.16540122
51Shigellosis_Homo sapiens_hsa051311.14656437
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.13447716
53Galactose metabolism_Homo sapiens_hsa000521.12813460
54Basal transcription factors_Homo sapiens_hsa030221.12239326
55Antigen processing and presentation_Homo sapiens_hsa046121.11792868
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.11529666
57Carbon metabolism_Homo sapiens_hsa012001.10346422
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01764895
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01218825
60Biosynthesis of amino acids_Homo sapiens_hsa012300.98458038
61Prion diseases_Homo sapiens_hsa050200.94956329
62Alzheimers disease_Homo sapiens_hsa050100.94771813
63Other glycan degradation_Homo sapiens_hsa005110.94130715
64RNA degradation_Homo sapiens_hsa030180.94037168
65Glutathione metabolism_Homo sapiens_hsa004800.91931535
66PPAR signaling pathway_Homo sapiens_hsa033200.90839550
67Sulfur metabolism_Homo sapiens_hsa009200.90221628
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89090248
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.88481485
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.88387700
71N-Glycan biosynthesis_Homo sapiens_hsa005100.87494726
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82021212
73Pancreatic cancer_Homo sapiens_hsa052120.80658158
74One carbon pool by folate_Homo sapiens_hsa006700.78872020
75Chemokine signaling pathway_Homo sapiens_hsa040620.77774573
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76480177
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76331634
78B cell receptor signaling pathway_Homo sapiens_hsa046620.76068892
79Long-term potentiation_Homo sapiens_hsa047200.75606948
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70940452
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70890830
82Focal adhesion_Homo sapiens_hsa045100.67158485
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66703507
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.66552320
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66407081
86Pyruvate metabolism_Homo sapiens_hsa006200.64793658
87Oocyte meiosis_Homo sapiens_hsa041140.64642377
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64286226
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63161751
90Fanconi anemia pathway_Homo sapiens_hsa034600.61841862
91Herpes simplex infection_Homo sapiens_hsa051680.60947165
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58486926
93ECM-receptor interaction_Homo sapiens_hsa045120.58265430
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56889919
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.55464130
96African trypanosomiasis_Homo sapiens_hsa051430.55422709
97Leishmaniasis_Homo sapiens_hsa051400.55385802
98Dilated cardiomyopathy_Homo sapiens_hsa054140.54396255
99Cardiac muscle contraction_Homo sapiens_hsa042600.53692707
100Vibrio cholerae infection_Homo sapiens_hsa051100.52492504
101Renin secretion_Homo sapiens_hsa049240.50123804
102Glycosaminoglycan degradation_Homo sapiens_hsa005310.50114750
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49634938
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49510117
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49445098
106Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49188952
107Apoptosis_Homo sapiens_hsa042100.49043755
108Collecting duct acid secretion_Homo sapiens_hsa049660.47025159
109Gastric acid secretion_Homo sapiens_hsa049710.46613935
110Metabolic pathways_Homo sapiens_hsa011000.46552223
111VEGF signaling pathway_Homo sapiens_hsa043700.46487802
112Cyanoamino acid metabolism_Homo sapiens_hsa004600.46383004
113Renal cell carcinoma_Homo sapiens_hsa052110.44780049
114Viral carcinogenesis_Homo sapiens_hsa052030.44697266
115Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43333739
116Thyroid cancer_Homo sapiens_hsa052160.43315386
117Glioma_Homo sapiens_hsa052140.43217163
118Pertussis_Homo sapiens_hsa051330.42298895
119Salmonella infection_Homo sapiens_hsa051320.41917711
120Acute myeloid leukemia_Homo sapiens_hsa052210.40880671
121Measles_Homo sapiens_hsa051620.40104738
122HIF-1 signaling pathway_Homo sapiens_hsa040660.39843613
123Phagosome_Homo sapiens_hsa041450.39714808
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.39511746
125Tuberculosis_Homo sapiens_hsa051520.38270389
126AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37467361
127AMPK signaling pathway_Homo sapiens_hsa041520.36406397
128HTLV-I infection_Homo sapiens_hsa051660.36386381
129Selenocompound metabolism_Homo sapiens_hsa004500.34730399
130Renin-angiotensin system_Homo sapiens_hsa046140.34027483
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33957680
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.33201654
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.33037810
134Circadian entrainment_Homo sapiens_hsa047130.32186952
135Pancreatic secretion_Homo sapiens_hsa049720.32055914
136Rheumatoid arthritis_Homo sapiens_hsa053230.31226962
137Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30261093
138Primary immunodeficiency_Homo sapiens_hsa053400.29820302
139Caffeine metabolism_Homo sapiens_hsa002320.29743930
140Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28559827
141Hepatitis B_Homo sapiens_hsa051610.28239328
142Malaria_Homo sapiens_hsa051440.27594953
143RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.27393163
144Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26727864
145* Endocytosis_Homo sapiens_hsa041440.26062314
146Arachidonic acid metabolism_Homo sapiens_hsa005900.24962886
147Leukocyte transendothelial migration_Homo sapiens_hsa046700.23820749
148Non-homologous end-joining_Homo sapiens_hsa034500.23741098
149Hematopoietic cell lineage_Homo sapiens_hsa046400.23594041
150Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.22624489
151Bladder cancer_Homo sapiens_hsa052190.22093215
152mRNA surveillance pathway_Homo sapiens_hsa030150.21681415
153Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.18240634
154Influenza A_Homo sapiens_hsa051640.17969065

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