SNX31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hypotonic response (GO:0006971)9.48652785
2aminoglycoside antibiotic metabolic process (GO:0030647)8.68815318
3glomerular visceral epithelial cell development (GO:0072015)8.10907785
4glomerular basement membrane development (GO:0032836)7.20800984
5urate metabolic process (GO:0046415)7.16870341
6drug transmembrane transport (GO:0006855)6.99609510
7glomerular epithelial cell development (GO:0072310)6.91006690
8glomerulus development (GO:0032835)5.98822986
9drug transport (GO:0015893)5.74916552
10behavioral response to nicotine (GO:0035095)5.56302984
11secondary heart field specification (GO:0003139)5.56164311
12heart field specification (GO:0003128)5.56164311
13cardiac ventricle formation (GO:0003211)5.44788034
14organic cation transport (GO:0015695)5.39753461
15cellular response to osmotic stress (GO:0071470)5.24908392
16hyperosmotic salinity response (GO:0042538)5.13630835
17potassium ion homeostasis (GO:0055075)5.07351353
18cardiac chamber formation (GO:0003207)5.02620774
19metanephric nephron tubule development (GO:0072234)4.98194869
20metanephric tubule development (GO:0072170)4.98194869
21specification of organ identity (GO:0010092)4.79605830
22metanephric epithelium development (GO:0072207)4.67687169
23oligosaccharide catabolic process (GO:0009313)4.58758977
24glycoside metabolic process (GO:0016137)4.52953229
25quaternary ammonium group transport (GO:0015697)4.52930467
26metanephric nephron epithelium development (GO:0072243)4.44903822
27exogenous drug catabolic process (GO:0042738)4.43489967
28lysine metabolic process (GO:0006553)4.30502007
29lysine catabolic process (GO:0006554)4.30502007
30excretion (GO:0007588)4.22560272
31piRNA metabolic process (GO:0034587)4.21762099
32phospholipid scrambling (GO:0017121)4.19083506
33glyoxylate metabolic process (GO:0046487)4.18790999
34centriole replication (GO:0007099)4.18067514
35nonribosomal peptide biosynthetic process (GO:0019184)4.12878123
36sodium ion homeostasis (GO:0055078)4.10429457
37cysteine metabolic process (GO:0006534)4.09938797
38response to mercury ion (GO:0046689)4.07521791
39phosphate ion transport (GO:0006817)4.06877068
40regulation of apoptotic process involved in morphogenesis (GO:1902337)4.02027793
41epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.97599755
42response to thyroid hormone (GO:0097066)3.97037751
43response to pheromone (GO:0019236)3.91236653
44toxin transport (GO:1901998)3.86906268
45negative regulation of erythrocyte differentiation (GO:0045647)3.85638440
46nephron epithelium morphogenesis (GO:0072088)3.82046619
47nephron tubule morphogenesis (GO:0072078)3.82046619
48cellular ketone body metabolic process (GO:0046950)3.81364533
49drug catabolic process (GO:0042737)3.80167822
50amine catabolic process (GO:0009310)3.79220987
51cellular biogenic amine catabolic process (GO:0042402)3.79220987
52fucose catabolic process (GO:0019317)3.79174077
53L-fucose metabolic process (GO:0042354)3.79174077
54L-fucose catabolic process (GO:0042355)3.79174077
55nephron epithelium development (GO:0072009)3.78786511
56positive regulation of uterine smooth muscle contraction (GO:0070474)3.77589596
57DNA methylation involved in gamete generation (GO:0043046)3.76463026
58nephron tubule development (GO:0072080)3.75201182
59DNA deamination (GO:0045006)3.72552541
60epithelial cilium movement (GO:0003351)3.71323494
61relaxation of smooth muscle (GO:0044557)3.68517932
62facial nerve structural organization (GO:0021612)3.68341412
63glucosamine-containing compound catabolic process (GO:1901072)3.65298514
64detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.63713143
65proline metabolic process (GO:0006560)3.59945383
66trivalent inorganic anion homeostasis (GO:0072506)3.47180913
67phosphate ion homeostasis (GO:0055062)3.47180913
68lung vasculature development (GO:0060426)3.47068427
69gamma-aminobutyric acid transport (GO:0015812)3.44818223
70positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.44654441
71renal absorption (GO:0070293)3.44528873
72positive regulation of neuroblast proliferation (GO:0002052)3.42898492
73glutathione biosynthetic process (GO:0006750)3.41661644
74purinergic nucleotide receptor signaling pathway (GO:0035590)3.37152353
75ketone body metabolic process (GO:1902224)3.36816489
76indole-containing compound catabolic process (GO:0042436)3.32640667
77indolalkylamine catabolic process (GO:0046218)3.32640667
78tryptophan catabolic process (GO:0006569)3.32640667
79kynurenine metabolic process (GO:0070189)3.29097564
80ribosomal small subunit assembly (GO:0000028)3.28195510
81regulation of axon guidance (GO:1902667)3.27705305
82negative regulation of axon guidance (GO:1902668)3.25191431
83phosphate ion transmembrane transport (GO:0035435)3.22557069
84indolalkylamine metabolic process (GO:0006586)3.20301202
85reciprocal meiotic recombination (GO:0007131)3.19255863
86reciprocal DNA recombination (GO:0035825)3.19255863
87retinal cone cell development (GO:0046549)3.18264007
88sulfate transmembrane transport (GO:1902358)3.17913614
89cilium movement (GO:0003341)3.16830397
90positive regulation of hormone metabolic process (GO:0032352)3.15080630
91regulation of rhodopsin mediated signaling pathway (GO:0022400)3.13986152
92detection of light stimulus involved in visual perception (GO:0050908)3.13737392
93detection of light stimulus involved in sensory perception (GO:0050962)3.13737392
94regulation of axon extension involved in axon guidance (GO:0048841)3.13256403
95sphingoid metabolic process (GO:0046519)3.11224518
96negative regulation of telomere maintenance (GO:0032205)3.10892416
97diol metabolic process (GO:0034311)3.10307047
98renal tubule development (GO:0061326)3.07923741
99sodium-independent organic anion transport (GO:0043252)3.07695951
100glutathione metabolic process (GO:0006749)3.07155792
101renal filtration (GO:0097205)3.06730828
102rhodopsin mediated signaling pathway (GO:0016056)3.05908788
103somite rostral/caudal axis specification (GO:0032525)3.05356469
104tonic smooth muscle contraction (GO:0014820)3.02853882
105regulation of action potential (GO:0098900)3.01587877
106negative regulation of axon extension involved in axon guidance (GO:0048843)3.00551289
107opioid receptor signaling pathway (GO:0038003)3.00105325
108response to parathyroid hormone (GO:0071107)2.99756791
109tryptophan metabolic process (GO:0006568)2.99298589
110negative regulation of metanephros development (GO:0072217)2.97433918
111benzene-containing compound metabolic process (GO:0042537)2.96601266
112G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.96022199
113platelet dense granule organization (GO:0060155)2.95936925
114histamine transport (GO:0051608)2.95145861
115peptide biosynthetic process (GO:0043043)2.95039097
116regulation of plasminogen activation (GO:0010755)2.94849351
117antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.94494988
118negative regulation of homotypic cell-cell adhesion (GO:0034111)2.94478022
119negative regulation of cardiac muscle hypertrophy (GO:0010614)2.92471134
120inositol metabolic process (GO:0006020)2.92233370
121phosphatidylinositol acyl-chain remodeling (GO:0036149)2.89843279
122tricarboxylic acid metabolic process (GO:0072350)2.89833517
123carnitine transport (GO:0015879)2.89626913
124amino-acid betaine transport (GO:0015838)2.89626913
125cellular response to thyroid hormone stimulus (GO:0097067)2.89438070
126short-chain fatty acid metabolic process (GO:0046459)2.88274554
127sphingosine metabolic process (GO:0006670)2.87470493
128renal tubule morphogenesis (GO:0061333)2.87155787
129T-helper 1 type immune response (GO:0042088)2.86498328
130positive regulation of cellular amine metabolic process (GO:0033240)2.86285716
131water transport (GO:0006833)2.85931687
132sulfate transport (GO:0008272)2.85106383
133neuronal action potential (GO:0019228)2.84688933
134centriole assembly (GO:0098534)2.84461889
135neurotransmitter biosynthetic process (GO:0042136)2.84079467
136cilium or flagellum-dependent cell motility (GO:0001539)2.83989990
137negative regulation of reactive oxygen species metabolic process (GO:2000378)2.83699914
138positive regulation of oligodendrocyte differentiation (GO:0048714)2.82963306
139primary amino compound metabolic process (GO:1901160)2.82715626
140somite development (GO:0061053)2.82253250
141protein-cofactor linkage (GO:0018065)2.82194972
142positive regulation of digestive system process (GO:0060456)2.81791536
143mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.81355062
144epithelial cell differentiation involved in kidney development (GO:0035850)2.79526187
145monoamine transport (GO:0015844)2.78086455
146regulation of histone phosphorylation (GO:0033127)2.77372669
147axoneme assembly (GO:0035082)2.76433755
148central nervous system myelination (GO:0022010)2.75169912
149axon ensheathment in central nervous system (GO:0032291)2.75169912
150positive regulation of action potential (GO:0045760)2.72001791
151regulation of inositol phosphate biosynthetic process (GO:0010919)2.71917975
152ganglion development (GO:0061548)2.71760234
153glomerular filtration (GO:0003094)2.71594754
154response to salt stress (GO:0009651)2.71339294
155regulation of mesoderm development (GO:2000380)2.70489458
156indole-containing compound metabolic process (GO:0042430)2.70462761
157cGMP-mediated signaling (GO:0019934)2.70354248
158branched-chain amino acid metabolic process (GO:0009081)2.70119689
159mitochondrial respiratory chain complex I assembly (GO:0032981)2.69618315
160NADH dehydrogenase complex assembly (GO:0010257)2.69618315
161mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.69618315
162hindbrain development (GO:0030902)2.69226945
163mannosylation (GO:0097502)2.69117531
164meiotic chromosome segregation (GO:0045132)2.67729308
165multicellular organism reproduction (GO:0032504)2.67715187
166synaptic transmission, cholinergic (GO:0007271)2.67535744
167cornea development in camera-type eye (GO:0061303)2.67260703
168serotonin metabolic process (GO:0042428)2.65557644
169neuron fate determination (GO:0048664)2.65072355
170xenobiotic catabolic process (GO:0042178)2.64569859
171establishment of protein localization to mitochondrial membrane (GO:0090151)2.63106020
172negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.62425443
173reflex (GO:0060004)2.61421576
174behavioral response to ethanol (GO:0048149)2.61375679
175RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.60279275
176tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.60279275
177protein complex biogenesis (GO:0070271)2.57128696
178cAMP catabolic process (GO:0006198)2.56204425
179axonemal dynein complex assembly (GO:0070286)2.54557263
180response to nitrosative stress (GO:0051409)2.54014971
181regulation of hippo signaling (GO:0035330)2.53838357
182nonmotile primary cilium assembly (GO:0035058)2.53806611
183regulation of meiosis I (GO:0060631)2.53260912
184photoreceptor cell development (GO:0042461)2.53243095
185positive regulation of meiosis (GO:0045836)2.53205067
186cilium organization (GO:0044782)2.53143351
187negative regulation of cytosolic calcium ion concentration (GO:0051481)2.52408954
188kidney morphogenesis (GO:0060993)2.51395225
189positive regulation of defense response to virus by host (GO:0002230)2.50601181
190negative regulation of mast cell activation (GO:0033004)2.50121335
191parturition (GO:0007567)2.49245173
192protein-chromophore linkage (GO:0018298)2.48369047
193male meiosis I (GO:0007141)2.47346857
194negative regulation of synaptic transmission, GABAergic (GO:0032229)2.45708509
195positive regulation of meiotic cell cycle (GO:0051446)2.44922872
196neural tube formation (GO:0001841)2.44205505
197positive regulation of fatty acid transport (GO:2000193)2.43585564
198phosphatidylserine acyl-chain remodeling (GO:0036150)2.41947265
199one-carbon compound transport (GO:0019755)11.2871544

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.78153255
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.52891566
3CHD7_19251738_ChIP-ChIP_MESCs_Mouse4.32840249
4EZH2_22144423_ChIP-Seq_EOC_Human4.02353839
5IGF1R_20145208_ChIP-Seq_DFB_Human3.61644681
6ZNF274_21170338_ChIP-Seq_K562_Hela3.36608116
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.16607086
8VDR_22108803_ChIP-Seq_LS180_Human3.12964214
9RARG_19884340_ChIP-ChIP_MEFs_Mouse3.01615165
10ERG_21242973_ChIP-ChIP_JURKAT_Human2.76459541
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.72481462
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.41893224
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.38024873
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.31370761
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.23418746
16PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.22623838
17CDX2_20551321_ChIP-Seq_CACO-2_Human2.16688786
18CTBP1_25329375_ChIP-Seq_LNCAP_Human2.11501982
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.11441078
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.00707531
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.98243058
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.97882033
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.97369483
24P300_19829295_ChIP-Seq_ESCs_Human1.88814842
25GBX2_23144817_ChIP-Seq_PC3_Human1.87817185
26FUS_26573619_Chip-Seq_HEK293_Human1.81939637
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.80511130
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.79527456
29ER_23166858_ChIP-Seq_MCF-7_Human1.78767773
30AR_21572438_ChIP-Seq_LNCaP_Human1.78671849
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78235187
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.73335907
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.73068219
34CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.72973937
35SCL_19346495_ChIP-Seq_HPC-7_Human1.72285731
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72006459
37* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.68980324
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.68729963
39LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.67325446
40SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.64499699
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63692051
42EWS_26573619_Chip-Seq_HEK293_Human1.62165045
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.61455445
44AR_21909140_ChIP-Seq_LNCAP_Human1.57891234
45TAF15_26573619_Chip-Seq_HEK293_Human1.57264154
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.57149852
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.56844453
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.56265364
49FOXA1_25329375_ChIP-Seq_VCAP_Human1.54702497
50FOXA1_27270436_Chip-Seq_PROSTATE_Human1.54702497
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.52151321
52TP53_18474530_ChIP-ChIP_U2OS_Human1.51011930
53SOX2_19829295_ChIP-Seq_ESCs_Human1.48989125
54NANOG_19829295_ChIP-Seq_ESCs_Human1.48989125
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.48866192
56AR_25329375_ChIP-Seq_VCAP_Human1.47428289
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46755241
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44848813
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44837673
60TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44837673
61SALL1_21062744_ChIP-ChIP_HESCs_Human1.43096729
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40751534
63HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.40098345
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39776278
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39162842
66STAT3_23295773_ChIP-Seq_U87_Human1.38468344
67EOMES_21245162_ChIP-Seq_HESCs_Human1.38235393
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37988639
69SMAD3_21741376_ChIP-Seq_HESCs_Human1.37439747
70REST_21632747_ChIP-Seq_MESCs_Mouse1.34988428
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34903282
72SUZ12_27294783_Chip-Seq_ESCs_Mouse1.33780678
73JARID2_20064375_ChIP-Seq_MESCs_Mouse1.33687940
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.32956759
75SMAD4_21799915_ChIP-Seq_A2780_Human1.32081447
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31720090
77SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31332656
78MTF2_20144788_ChIP-Seq_MESCs_Mouse1.30586919
79TCF4_23295773_ChIP-Seq_U87_Human1.29829782
80RNF2_18974828_ChIP-Seq_MESCs_Mouse1.29230437
81EZH2_18974828_ChIP-Seq_MESCs_Mouse1.29230437
82ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.27822534
83ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27471389
84FOXA1_21572438_ChIP-Seq_LNCaP_Human1.26758635
85SMAD3_21741376_ChIP-Seq_EPCs_Human1.26708140
86SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26629042
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26385460
88CBP_20019798_ChIP-Seq_JUKART_Human1.26385460
89TP53_22573176_ChIP-Seq_HFKS_Human1.26119886
90ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.25428043
91TCF4_22108803_ChIP-Seq_LS180_Human1.25342832
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25211645
93SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.24423287
94HOXB7_26014856_ChIP-Seq_BT474_Human1.23760528
95CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.23068707
96PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21479961
97NCOR_22424771_ChIP-Seq_293T_Human1.21419930
98AUTS2_25519132_ChIP-Seq_293T-REX_Human1.19966298
99EZH2_27294783_Chip-Seq_ESCs_Mouse1.19444869
100* RUNX2_22187159_ChIP-Seq_PCA_Human1.19270441
101ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18786270
102EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.18502256
103GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17357261
104EZH2_27294783_Chip-Seq_NPCs_Mouse1.16724348
105SMAD4_21741376_ChIP-Seq_EPCs_Human1.14222729
106EZH2_27304074_Chip-Seq_ESCs_Mouse1.13914980
107SOX2_20726797_ChIP-Seq_SW620_Human1.13338941
108* PRDM14_20953172_ChIP-Seq_ESCs_Human1.13155199
109PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.11346139
110NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.11020653
111* AR_20517297_ChIP-Seq_VCAP_Human1.10175923
112* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10011835
113KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09800054
114GATA1_19941827_ChIP-Seq_MEL_Mouse1.08795864
115JARID2_20075857_ChIP-Seq_MESCs_Mouse1.08382546
116RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07716020
117WDR5_24793694_ChIP-Seq_LNCAP_Human1.07627434
118CLOCK_20551151_ChIP-Seq_293T_Human1.07384156
119TAF2_19829295_ChIP-Seq_ESCs_Human1.06217551
120NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03623559
121SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03312132
122* NANOG_20526341_ChIP-Seq_ESCs_Human1.02384204
123FLI1_21867929_ChIP-Seq_TH2_Mouse1.01370724
124CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00971947
125LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00792211
126P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00324220
127SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.00263270
128MYC_18940864_ChIP-ChIP_HL60_Human1.00101360
129SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99567581
130TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99184562
131BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.98639787
132GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98083641
133TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97989928
134THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97798647
135WT1_19549856_ChIP-ChIP_CCG9911_Human0.97717538
136CRX_20693478_ChIP-Seq_RETINA_Mouse0.96958808
137TP63_19390658_ChIP-ChIP_HaCaT_Human0.96861978
138NANOG_18555785_Chip-Seq_ESCs_Mouse0.96677976
139RNF2_27304074_Chip-Seq_ESCs_Mouse0.96547698
140MYC_19829295_ChIP-Seq_ESCs_Human0.96535038
141SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.95275189
142GATA3_21878914_ChIP-Seq_MCF-7_Human0.94115407
143SMAD4_21741376_ChIP-Seq_HESCs_Human0.93743660
144TCF4_18268006_ChIP-ChIP_LS174T_Human0.92559913
145GATA4_25053715_ChIP-Seq_YYC3_Human0.92422444
146CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.90510206
147LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88642991
148RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.88564410
149RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.88043360
150GATA1_19941827_ChIP-Seq_MEL86_Mouse0.87180341
151GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.85659821
152RNF2_27304074_Chip-Seq_NSC_Mouse0.85064507
153RXR_22158963_ChIP-Seq_LIVER_Mouse0.85025516
154CTBP2_25329375_ChIP-Seq_LNCAP_Human0.84930742
155BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84576138
156BCAT_22108803_ChIP-Seq_LS180_Human0.82176672
157ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80625052
158PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.80410750
159RXR_22108803_ChIP-Seq_LS180_Human0.80067593
160WT1_25993318_ChIP-Seq_PODOCYTE_Human0.79698991
161FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78604576
162STAT3_1855785_ChIP-Seq_MESCs_Mouse0.78548296
163ESR2_21235772_ChIP-Seq_MCF-7_Human0.77885415
164GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77842230
165TCF3_18692474_ChIP-Seq_MESCs_Mouse0.76484705
166HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.76046050
167JUN_21703547_ChIP-Seq_K562_Human0.75930176
168ZNF263_19887448_ChIP-Seq_K562_Human0.75767066
169SOX2_22085726_ChIP-Seq_NPCs_Mouse0.75227332
170CTCF_18555785_ChIP-Seq_MESCs_Mouse0.74509828
171E2F7_22180533_ChIP-Seq_HELA_Human0.71931458
172CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.71669249
173GATA1_22383799_ChIP-Seq_G1ME_Mouse0.70996225
174TCF3_18692474_ChIP-Seq_MEFs_Mouse0.70516109
175SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.70451728
176TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.69802362
177ESR1_15608294_ChIP-ChIP_MCF-7_Human0.69630844
178SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.69153317
179PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.68115614

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010386_abnormal_urinary_bladder9.18432951
2MP0005367_renal/urinary_system_phenotyp8.87874011
3MP0000516_abnormal_urinary_system8.87874011
4MP0003136_yellow_coat_color5.04939600
5MP0001756_abnormal_urination3.46537112
6MP0000534_abnormal_ureter_morphology3.31155962
7MP0005332_abnormal_amino_acid3.28333565
8MP0000569_abnormal_digit_pigmentation3.03109877
9MP0002653_abnormal_ependyma_morphology2.90926773
10MP0009643_abnormal_urine_homeostasis2.62168121
11MP0005360_urolithiasis2.61760700
12MP0003011_delayed_dark_adaptation2.40452614
13MP0002102_abnormal_ear_morphology2.36423084
14MP0001958_emphysema2.32449396
15MP0005551_abnormal_eye_electrophysiolog2.22185167
16MP0002136_abnormal_kidney_physiology2.21278246
17MP0002938_white_spotting2.12144641
18MP0003283_abnormal_digestive_organ2.08937352
19MP0001968_abnormal_touch/_nociception2.08547392
20MP0003878_abnormal_ear_physiology1.92966804
21MP0005377_hearing/vestibular/ear_phenot1.92966804
22MP0006054_spinal_hemorrhage1.90799199
23MP0005171_absent_coat_pigmentation1.90291825
24MP0006072_abnormal_retinal_apoptosis1.90118678
25MP0002736_abnormal_nociception_after1.84869033
26MP0002277_abnormal_respiratory_mucosa1.84438164
27MP0003890_abnormal_embryonic-extraembry1.83932349
28MP0000230_abnormal_systemic_arterial1.83897611
29MP0008877_abnormal_DNA_methylation1.83721982
30MP0002638_abnormal_pupillary_reflex1.80001777
31MP0004142_abnormal_muscle_tone1.78518337
32MP0009745_abnormal_behavioral_response1.78197954
33MP0000566_synostosis1.74516127
34MP0001501_abnormal_sleep_pattern1.73703561
35MP0002272_abnormal_nervous_system1.72624077
36MP0005646_abnormal_pituitary_gland1.72353977
37MP0008872_abnormal_physiological_respon1.71390797
38MP0004043_abnormal_pH_regulation1.64880143
39MP0005253_abnormal_eye_physiology1.64833912
40MP0005645_abnormal_hypothalamus_physiol1.60583592
41MP0002735_abnormal_chemical_nociception1.60290608
42MP0001485_abnormal_pinna_reflex1.57645803
43MP0000538_abnormal_urinary_bladder1.56049190
44MP0004019_abnormal_vitamin_homeostasis1.54859707
45MP0001765_abnormal_ion_homeostasis1.50767310
46MP0004742_abnormal_vestibular_system1.49763082
47MP0001664_abnormal_digestion1.49042089
48MP0002139_abnormal_hepatobiliary_system1.48798727
49MP0004147_increased_porphyrin_level1.46507883
50MP0000372_irregular_coat_pigmentation1.45595665
51MP0001486_abnormal_startle_reflex1.45187416
52MP0009046_muscle_twitch1.44896415
53MP0008875_abnormal_xenobiotic_pharmacok1.43271751
54MP0004036_abnormal_muscle_relaxation1.43045768
55MP0001986_abnormal_taste_sensitivity1.36993855
56MP0006292_abnormal_olfactory_placode1.35912069
57MP0002135_abnormal_kidney_morphology1.34775033
58MP0000427_abnormal_hair_cycle1.32067252
59MP0003315_abnormal_perineum_morphology1.31270906
60MP0002572_abnormal_emotion/affect_behav1.30445767
61MP0003880_abnormal_central_pattern1.27078176
62MP0002064_seizures1.24279031
63MP0002160_abnormal_reproductive_system1.23801993
64MP0005084_abnormal_gallbladder_morpholo1.22984021
65MP0000631_abnormal_neuroendocrine_gland1.21132029
66MP0000026_abnormal_inner_ear1.20206792
67MP0002067_abnormal_sensory_capabilities1.17830949
68MP0001502_abnormal_circadian_rhythm1.15350902
69MP0001905_abnormal_dopamine_level1.13934314
70MP0004885_abnormal_endolymph1.12836630
71MP0001984_abnormal_olfaction1.10950760
72MP0002138_abnormal_hepatobiliary_system1.06041232
73MP0001970_abnormal_pain_threshold1.05995699
74MP0002095_abnormal_skin_pigmentation1.05521281
75MP0002733_abnormal_thermal_nociception1.04974699
76MP0003866_abnormal_defecation1.04224859
77MP0002163_abnormal_gland_morphology1.04070503
78MP0003137_abnormal_impulse_conducting1.02011384
79MP0005423_abnormal_somatic_nervous1.01474279
80MP0003938_abnormal_ear_development1.01113286
81MP0002009_preneoplasia1.00944304
82MP0004381_abnormal_hair_follicle1.00368573
83MP0005365_abnormal_bile_salt0.99842907
84MP0004133_heterotaxia0.99529523
85MP0005636_abnormal_mineral_homeostasis0.99364920
86MP0002557_abnormal_social/conspecific_i0.98679990
87MP0005389_reproductive_system_phenotype0.97841277
88MP0004084_abnormal_cardiac_muscle0.94878991
89MP0002063_abnormal_learning/memory/cond0.93715316
90MP0003252_abnormal_bile_duct0.93408157
91MP0002234_abnormal_pharynx_morphology0.92795313
92MP0000751_myopathy0.92699701
93MP0004272_abnormal_basement_membrane0.90205555
94MP0005075_abnormal_melanosome_morpholog0.90149107
95MP0005386_behavior/neurological_phenoty0.90038018
96MP0004924_abnormal_behavior0.90038018
97MP0005409_darkened_coat_color0.90006725
98MP0006276_abnormal_autonomic_nervous0.89613610
99MP0005410_abnormal_fertilization0.88100991
100MP0003045_fibrosis0.87765519
101MP0002751_abnormal_autonomic_nervous0.87669482
102MP0002796_impaired_skin_barrier0.87414259
103MP0005195_abnormal_posterior_eye0.87326103
104MP0003635_abnormal_synaptic_transmissio0.86529174
105MP0000462_abnormal_digestive_system0.84925611
106MP0008961_abnormal_basal_metabolism0.83717944
107MP0001879_abnormal_lymphatic_vessel0.83478451
108MP0003941_abnormal_skin_development0.81095381
109MP0004215_abnormal_myocardial_fiber0.80993555
110MP0003724_increased_susceptibility_to0.80618113
111MP0002229_neurodegeneration0.79468754
112MP0002837_dystrophic_cardiac_calcinosis0.78509095
113MP0002752_abnormal_somatic_nervous0.77504660
114MP0001324_abnormal_eye_pigmentation0.77328410
115MP0002396_abnormal_hematopoietic_system0.77079342
116MP0000013_abnormal_adipose_tissue0.76755366
117MP0000343_altered_response_to0.76183107
118MP0005381_digestive/alimentary_phenotyp0.74717562
119MP0001529_abnormal_vocalization0.74213443
120MP0004145_abnormal_muscle_electrophysio0.74025589
121MP0005083_abnormal_biliary_tract0.73675760
122MP0003698_abnormal_male_reproductive0.73541755
123MP0000470_abnormal_stomach_morphology0.73443556
124MP0005620_abnormal_muscle_contractility0.72807750
125MP0000778_abnormal_nervous_system0.72794129
126MP0005379_endocrine/exocrine_gland_phen0.72772763
127MP0001270_distended_abdomen0.72334527
128MP0003646_muscle_fatigue0.72279044
129MP0009384_cardiac_valve_regurgitation0.71560625
130MP0003943_abnormal_hepatobiliary_system0.71351060
131MP0010368_abnormal_lymphatic_system0.70697485
132MP0010155_abnormal_intestine_physiology0.68218068
133MP0005319_abnormal_enzyme/_coenzyme0.68140468
134MP0000537_abnormal_urethra_morphology0.65142566
135MP0003566_abnormal_cell_adhesion0.63730919
136MP0005595_abnormal_vascular_smooth0.63595271
137MP0003186_abnormal_redox_activity0.62689353
138MP0001663_abnormal_digestive_system0.62654355
139MP0000383_abnormal_hair_follicle0.62592246
140MP0003300_gastrointestinal_ulcer0.62504501
141MP0005165_increased_susceptibility_to0.62246417
142MP0000467_abnormal_esophagus_morphology0.61992785
143MP0002928_abnormal_bile_duct0.61275746
144MP0005584_abnormal_enzyme/coenzyme_acti0.60052964
145MP0003172_abnormal_lysosome_physiology0.59118166
146MP0005197_abnormal_uvea_morphology0.57707928
147MP0005085_abnormal_gallbladder_physiolo0.55540989
148MP0000477_abnormal_intestine_morphology0.53455877
149MP0000678_abnormal_parathyroid_gland0.50566290
150MP0002098_abnormal_vibrissa_morphology0.50469210
151MP0002166_altered_tumor_susceptibility0.50421295
152MP0001963_abnormal_hearing_physiology0.49049104
153MP0005503_abnormal_tendon_morphology0.48049512
154MP0005501_abnormal_skin_physiology0.47956195
155MP0009379_abnormal_foot_pigmentation0.46786087
156MP0005330_cardiomyopathy0.46770522
157MP0008775_abnormal_heart_ventricle0.45266445
158MP0001835_abnormal_antigen_presentation0.43805067
159MP0002876_abnormal_thyroid_physiology0.43665274
160MP0009053_abnormal_anal_canal0.42742853
161MP0005464_abnormal_platelet_physiology0.42449711
162MP0009764_decreased_sensitivity_to0.41989722
163MP0006036_abnormal_mitochondrial_physio0.41349714
164MP0005187_abnormal_penis_morphology0.39184649
165MP0003879_abnormal_hair_cell0.38812924
166MP0001731_abnormal_postnatal_growth0.38159168
167MP0008469_abnormal_protein_level0.37365701
168MP0003195_calcinosis0.37301467
169MP0003942_abnormal_urinary_system0.37077675
170MP0003718_maternal_effect0.35875440
171MP0009642_abnormal_blood_homeostasis0.35673355
172MP0010678_abnormal_skin_adnexa0.35023262
173MP0005174_abnormal_tail_pigmentation0.34671883
174MP0003937_abnormal_limbs/digits/tail_de0.34287608
175MP0002092_abnormal_eye_morphology0.34014559
176MP0005166_decreased_susceptibility_to0.33321041
177MP0003828_pulmonary_edema0.33055581
178MP0001915_intracranial_hemorrhage0.32267995

Predicted human phenotypes

RankGene SetZ-score
1Aortic aneurysm (HP:0004942)7.46782759
2Type II lissencephaly (HP:0007260)5.16782131
3Malnutrition (HP:0004395)5.12813679
4Hypomagnesemia (HP:0002917)5.12386739
5Aortic dissection (HP:0002647)4.52411587
6Cerebellar dysplasia (HP:0007033)4.50418490
7Abnormal pupillary function (HP:0007686)4.41462486
8Pancreatic cysts (HP:0001737)4.38962506
9Abnormality of magnesium homeostasis (HP:0004921)4.16628422
10Hypoplasia of the pons (HP:0012110)3.91270152
11Abnormality of midbrain morphology (HP:0002418)3.89254516
12Molar tooth sign on MRI (HP:0002419)3.89254516
13Abnormality of the pons (HP:0007361)3.89077801
14Ankle contracture (HP:0006466)3.79443581
15Gastrointestinal dysmotility (HP:0002579)3.78027567
16Retinal dysplasia (HP:0007973)3.72670718
17Pancreatic fibrosis (HP:0100732)3.72529417
18Hypokalemic alkalosis (HP:0001949)3.68481438
19Facial diplegia (HP:0001349)3.68069297
20Nephronophthisis (HP:0000090)3.64222585
21True hermaphroditism (HP:0010459)3.62215788
22Increased circulating renin level (HP:0000848)3.61300715
23Persistence of primary teeth (HP:0006335)3.56808512
24Congenital stationary night blindness (HP:0007642)3.44969431
25Reticulocytopenia (HP:0001896)3.28379374
26Abnormality of the renal medulla (HP:0100957)3.28122809
27Metabolic alkalosis (HP:0200114)3.25190115
28Gout (HP:0001997)3.25161990
29Abnormality of the renal cortex (HP:0011035)3.24239504
30Abnormality of chloride homeostasis (HP:0011422)3.21959348
31Neoplasm of the heart (HP:0100544)3.21219535
32Abnormal foot bone ossification (HP:0010675)3.14149711
33Mesangial abnormality (HP:0001966)3.11520541
34Tetany (HP:0001281)3.11269236
35Focal segmental glomerulosclerosis (HP:0000097)3.06646060
36Hyperactive renin-angiotensin system (HP:0000841)3.05738285
37Metaphyseal dysplasia (HP:0100255)3.04529603
38Polyuria (HP:0000103)3.04098933
39Medial flaring of the eyebrow (HP:0010747)3.03495621
40Broad distal phalanx of finger (HP:0009836)3.00657858
41Focal motor seizures (HP:0011153)2.99745999
42Abolished electroretinogram (ERG) (HP:0000550)2.92262845
43Cystic liver disease (HP:0006706)2.86691421
44Absent/shortened dynein arms (HP:0200106)2.86107184
45Dynein arm defect of respiratory motile cilia (HP:0012255)2.86107184
46Abnormality of glutamine family amino acid metabolism (HP:0010902)2.84875651
47Stridor (HP:0010307)2.83248634
48Abnormality of abdominal situs (HP:0011620)2.82484056
49Abdominal situs inversus (HP:0003363)2.82484056
50Retinal atrophy (HP:0001105)2.80403826
51Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.77651696
52Spastic diplegia (HP:0001264)2.76358530
53Abnormal urine output (HP:0012590)2.74931641
54Hypercalciuria (HP:0002150)2.74053166
55Large for gestational age (HP:0001520)2.72697877
56Congenital, generalized hypertrichosis (HP:0004540)2.72566223
57Broad face (HP:0000283)2.72172000
58Glomerulosclerosis (HP:0000096)2.71441325
59Cerebral aneurysm (HP:0004944)2.70452719
60Hyperphosphaturia (HP:0003109)2.69894603
61Knee flexion contracture (HP:0006380)2.68923006
62Abnormality of renal excretion (HP:0011036)2.68792566
63Abnormal ossification of hand bones (HP:0005921)2.68176059
64Abnormality of serine family amino acid metabolism (HP:0010894)2.68054399
65Abnormality of glycine metabolism (HP:0010895)2.68054399
66Hyperglycinemia (HP:0002154)2.66425760
67Hyperglycinuria (HP:0003108)2.60033914
68Tubular atrophy (HP:0000092)2.59510824
69Amelogenesis imperfecta (HP:0000705)2.57933190
70Abnormality of carpal bone ossification (HP:0006257)2.55805681
71Radial bowing (HP:0002986)2.55493178
72Abnormal drinking behavior (HP:0030082)2.54755236
73Polydipsia (HP:0001959)2.54755236
74Progressive inability to walk (HP:0002505)2.53271787
75Abnormality of purine metabolism (HP:0004352)2.52908101
76Abnormal tarsal ossification (HP:0008369)2.51866394
77Decreased circulating renin level (HP:0003351)2.48684852
78Aplastic anemia (HP:0001915)2.48194455
79Vacuolated lymphocytes (HP:0001922)2.46539408
80Hemangiomatosis (HP:0007461)2.44575765
81Lissencephaly (HP:0001339)2.42903772
82Decreased electroretinogram (ERG) amplitude (HP:0000654)2.42708091
83Proximal tubulopathy (HP:0000114)2.42054012
84Inability to walk (HP:0002540)2.42030214
85Concave nail (HP:0001598)2.40489535
86Abnormal urine phosphate concentration (HP:0012599)2.39955604
87Sclerocornea (HP:0000647)2.39608485
88Abnormal respiratory motile cilium morphology (HP:0005938)2.38073790
89Abnormal respiratory epithelium morphology (HP:0012253)2.38073790
90Methylmalonic aciduria (HP:0012120)2.33931424
91Abnormality of the 2nd finger (HP:0004100)2.32648510
92Hydroureter (HP:0000072)2.31605249
93Increased purine levels (HP:0004368)2.30797968
94Hyperuricemia (HP:0002149)2.30797968
95Metaphyseal cupping (HP:0003021)2.30668006
96Chronic hepatic failure (HP:0100626)2.30571897
97Gait imbalance (HP:0002141)2.29953786
98Parakeratosis (HP:0001036)2.27926479
99Pendular nystagmus (HP:0012043)2.26623684
100Abnormal ciliary motility (HP:0012262)2.26248342
101Glycosuria (HP:0003076)2.25951779
102Abnormality of urine glucose concentration (HP:0011016)2.25951779
103Hepatocellular necrosis (HP:0001404)2.25623684
104Hyperventilation (HP:0002883)2.24666298
105Increased density of long bones (HP:0006392)2.24098454
106Congenital hepatic fibrosis (HP:0002612)2.23973617
107Abnormal number of erythroid precursors (HP:0012131)2.23470059
108Nonprogressive disorder (HP:0003680)2.23364083
109Severe muscular hypotonia (HP:0006829)2.22299504
110Generalized aminoaciduria (HP:0002909)2.22138564
111Ulnar bowing (HP:0003031)2.17819456
112Attenuation of retinal blood vessels (HP:0007843)2.16575081
113Optic nerve hypoplasia (HP:0000609)2.16180590
114Capillary hemangiomas (HP:0005306)2.14875475
115Ketosis (HP:0001946)2.12445373
116Abnormality of nucleobase metabolism (HP:0010932)2.12352066
117Flared metaphyses (HP:0003015)2.12086719
118Hypophosphatemia (HP:0002148)2.11862845
119Absent frontal sinuses (HP:0002688)2.10663680
120Delayed epiphyseal ossification (HP:0002663)2.10364186
121Hydroxyprolinuria (HP:0003080)2.10244984
122Abnormality of proline metabolism (HP:0010907)2.10244984
123Congenital primary aphakia (HP:0007707)2.10019899
124Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.09082248
125Alkalosis (HP:0001948)2.08943116
126Hyperaldosteronism (HP:0000859)2.08446821
127Furrowed tongue (HP:0000221)2.05947985
128IgG deficiency (HP:0004315)2.05103285
129Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.04915596
130Elbow flexion contracture (HP:0002987)2.04762151
131Hip contracture (HP:0003273)2.03718065
132Aplasia/Hypoplasia of the uvula (HP:0010293)2.03668644
133Conical tooth (HP:0000698)2.02790293
134Dialeptic seizures (HP:0011146)2.02765664
135Stage 5 chronic kidney disease (HP:0003774)2.02248405
136Ureteral stenosis (HP:0000071)2.02136276
137Abnormality of renin-angiotensin system (HP:0000847)1.99152193
138Increased corneal curvature (HP:0100692)1.98789704
139Keratoconus (HP:0000563)1.98789704
140Stomach cancer (HP:0012126)1.98772360
141Aplasia of the musculature (HP:0100854)1.98397719
142Renal tubular acidosis (HP:0001947)1.98245694
143Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.97872262
144Non-midline cleft lip (HP:0100335)1.96170129
145Hepatic necrosis (HP:0002605)1.95508757
146Nephrogenic diabetes insipidus (HP:0009806)1.94980900
147Abnormality of alanine metabolism (HP:0010916)1.93324078
148Hyperalaninemia (HP:0003348)1.93324078
149Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93324078
150Renal cortical cysts (HP:0000803)1.92662084
151Progressive cerebellar ataxia (HP:0002073)1.91712186
152Hyperparathyroidism (HP:0000843)1.91488414
153Aplasia/Hypoplasia of the tongue (HP:0010295)1.90246341
154Pancytopenia (HP:0001876)1.90207945
155Renal salt wasting (HP:0000127)1.90159031
156Anencephaly (HP:0002323)1.90130234
157Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.89258565
158Hypoalbuminemia (HP:0003073)1.89097374
159Abnormal albumin level (HP:0012116)1.89097374
160Abnormal respiratory motile cilium physiology (HP:0012261)1.88342008
161Bicuspid aortic valve (HP:0001647)1.87772750
162Abnormality of cells of the erythroid lineage (HP:0012130)1.87054206
163Ulnar claw (HP:0001178)1.86474636
164Bilateral sensorineural hearing impairment (HP:0008619)1.86001888
165Tubulointerstitial fibrosis (HP:0005576)1.85910370
166Postaxial foot polydactyly (HP:0001830)1.85832294
167Bowing of the arm (HP:0006488)1.85716038
168Bowed forearm bones (HP:0003956)1.85716038
169Neonatal onset (HP:0003623)1.85444324
170Pachygyria (HP:0001302)1.84835628
171Gaze-evoked nystagmus (HP:0000640)1.83743164
1723-Methylglutaconic aciduria (HP:0003535)1.83742299
173Bilateral microphthalmos (HP:0007633)1.83715924
174Abnormality of the vitreous humor (HP:0004327)1.80585080
175Abnormal rod and cone electroretinograms (HP:0008323)1.77844429
176Genital tract atresia (HP:0001827)1.77747497
177Hypothermia (HP:0002045)1.77457120
178Septo-optic dysplasia (HP:0100842)1.76330970
179Clumsiness (HP:0002312)1.76189470
180Colon cancer (HP:0003003)1.75895586
181Vaginal atresia (HP:0000148)1.75737198
182Absent thumb (HP:0009777)1.75381164
183Anterior segment dysgenesis (HP:0007700)1.75183802
184Chorioretinal atrophy (HP:0000533)1.74527819
185Patellar aplasia (HP:0006443)1.72820731
186Tubulointerstitial abnormality (HP:0001969)1.71918718
187Hemiparesis (HP:0001269)1.70950352
188Male pseudohermaphroditism (HP:0000037)1.70259519
189Genetic anticipation (HP:0003743)1.68984163
190Aplasia/Hypoplasia of the patella (HP:0006498)1.68385259
191Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.68378723

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK7.08708585
2TTN6.76095170
3WNK44.27668490
4FRK3.80481894
5OXSR13.07466178
6ZAK2.67893297
7TXK2.60175073
8WNK12.59345133
9ACVR1B2.59133349
10TNIK2.57392637
11ADRBK22.52999426
12TGFBR12.30422991
13MAPK152.27931327
14TAOK32.25275733
15TLK12.15165601
16EPHB22.05762163
17WNK32.02810125
18STK391.95762827
19PIK3CG1.95409248
20NEK11.93563468
21PAK21.89975857
22INSRR1.87654724
23GRK11.86923852
24BCKDK1.80989163
25BMPR1B1.76791506
26EPHA31.76730448
27MAP3K131.75917240
28MAP2K21.71097350
29DMPK1.64367066
30TSSK61.63835449
31MAPK131.55344207
32MAP4K21.51025010
33DAPK21.43863118
34EPHB11.42172476
35WEE11.42088274
36TGFBR21.42047922
37NUAK11.40491634
38PINK11.39582187
39LATS21.31523568
40MST1R1.27172571
41MUSK1.21241759
42DYRK21.20431220
43VRK11.19469934
44CDK191.14670690
45NTRK21.14466061
46PBK1.12112645
47MINK11.11361690
48ARAF1.10987637
49CDC71.10547341
50MATK1.08180107
51MARK11.07889324
52MKNK11.05415243
53PNCK1.02919388
54STK381.00770244
55CAMK2G0.99918630
56MARK30.97094313
57NME10.95700020
58STK110.89756856
59TAF10.87434284
60PRKCG0.85927501
61PTK2B0.84295686
62TEC0.81834515
63GRK50.81099094
64PHKG20.80685280
65PHKG10.80685280
66MAP3K120.80551233
67PRKD30.80384446
68VRK20.77501049
69RPS6KA60.76822285
70PAK30.76716602
71NTRK30.76152187
72PIK3CA0.75796630
73MAPKAPK50.74860024
74IKBKB0.74379740
75STK30.73469988
76NLK0.73271113
77CAMK10.72318300
78PRKCE0.71597277
79MAPKAPK30.70689120
80PASK0.70394715
81CHUK0.68875368
82BCR0.67721237
83DYRK30.67086557
84MAP3K40.66586828
85MELK0.66134156
86CDC42BPA0.65646813
87CCNB10.65207467
88MAP2K70.64921528
89PRKD20.63499025
90CAMK2B0.61878919
91PRKCH0.60878801
92FGFR40.59307880
93MST40.59020082
94BTK0.58209398
95NEK20.58068418
96KIT0.58044920
97PAK10.57785058
98RPS6KA20.56955782
99BRSK20.56836550
100GSK3A0.56615766
101CDK80.55618588
102MAP3K140.55618121
103STK100.55028263
104PRKACB0.52749655
105PIM10.51473717
106TRIM280.51229490
107AKT30.49418510
108TYRO30.48028340
109EPHA40.46853475
110FER0.46698152
111GRK70.44286465
112MAPK40.43456278
113PKN10.41964756
114CDK30.41914118
115STK38L0.41427402
116ALK0.40654862
117LATS10.40561950
118RAF10.40255959
119FGFR20.38476776
120STK160.38376842
121PRKACA0.38353081
122RPS6KA50.38275404
123PRKCQ0.38221585
124CAMK2A0.37994135
125MAP3K70.34449454
126FLT30.33852848
127LIMK10.33346111
128PIM20.32736783
129IRAK30.32717426
130OBSCN0.32641129
131TIE10.32599245
132PRKCI0.32133019
133PDK20.32101946
134PAK40.31900986
135ROCK20.31727329
136ERBB20.30286858
137CSNK1D0.29408262
138MAP2K60.28989646
139PDK10.28534697
140MAP2K10.28521354
141PLK40.28468659
142PLK30.28231361
143MKNK20.27459847
144ABL20.27234289
145PDK30.26723237
146PDK40.26723237
147LRRK20.25830341
148FGR0.24981246
149CAMKK20.24947793
150CHEK20.24680859
151ADRBK10.24584270
152RPS6KC10.24579057
153RPS6KL10.24579057
154MAP2K40.24539738
155MAPKAPK20.24428599
156IRAK10.23675275
157CASK0.22360076
158CSF1R0.22261186
159BRAF0.22109264
160LMTK20.21342668
161EIF2AK20.19773901
162DAPK30.19082464

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.64110876
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.97190462
3Phototransduction_Homo sapiens_hsa047443.47327954
4Butanoate metabolism_Homo sapiens_hsa006503.30830082
5Bladder cancer_Homo sapiens_hsa052193.15147459
6Linoleic acid metabolism_Homo sapiens_hsa005912.95762863
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.85119683
8beta-Alanine metabolism_Homo sapiens_hsa004102.82259763
9Nitrogen metabolism_Homo sapiens_hsa009102.81926665
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.81692374
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.81517351
12Nicotine addiction_Homo sapiens_hsa050332.80830842
13Histidine metabolism_Homo sapiens_hsa003402.63829355
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.47744717
15Other glycan degradation_Homo sapiens_hsa005112.43085704
16Maturity onset diabetes of the young_Homo sapiens_hsa049502.38893774
17Peroxisome_Homo sapiens_hsa041462.34103480
18Propanoate metabolism_Homo sapiens_hsa006402.29039272
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.24149741
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.08150900
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.02698420
22Ribosome_Homo sapiens_hsa030101.95152095
23Vascular smooth muscle contraction_Homo sapiens_hsa042701.88196802
24Tryptophan metabolism_Homo sapiens_hsa003801.87446271
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.86577689
26Phenylalanine metabolism_Homo sapiens_hsa003601.83876560
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.82599915
28Folate biosynthesis_Homo sapiens_hsa007901.80257170
29Glutathione metabolism_Homo sapiens_hsa004801.76930269
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.75079922
31Morphine addiction_Homo sapiens_hsa050321.67582715
32Fatty acid degradation_Homo sapiens_hsa000711.63131111
33Protein digestion and absorption_Homo sapiens_hsa049741.57245523
34Homologous recombination_Homo sapiens_hsa034401.54170803
35Basal transcription factors_Homo sapiens_hsa030221.50170270
36Arginine and proline metabolism_Homo sapiens_hsa003301.49591906
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.49008929
38Ether lipid metabolism_Homo sapiens_hsa005651.48407882
39Pyruvate metabolism_Homo sapiens_hsa006201.47320722
40RNA polymerase_Homo sapiens_hsa030201.42694094
41Collecting duct acid secretion_Homo sapiens_hsa049661.42223508
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.38724985
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.36462382
44GABAergic synapse_Homo sapiens_hsa047271.34996600
45Olfactory transduction_Homo sapiens_hsa047401.34658388
46Oxidative phosphorylation_Homo sapiens_hsa001901.34595778
47Parkinsons disease_Homo sapiens_hsa050121.33086207
48ECM-receptor interaction_Homo sapiens_hsa045121.25572080
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22312691
50Fanconi anemia pathway_Homo sapiens_hsa034601.22305526
51Sulfur metabolism_Homo sapiens_hsa009201.20689996
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.18982379
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.18012044
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.14830980
55Sulfur relay system_Homo sapiens_hsa041221.12996654
56Selenocompound metabolism_Homo sapiens_hsa004501.12731867
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.11606220
58Chemical carcinogenesis_Homo sapiens_hsa052041.08621754
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05793729
60Circadian entrainment_Homo sapiens_hsa047131.05585346
61Glutamatergic synapse_Homo sapiens_hsa047241.05583752
62Insulin secretion_Homo sapiens_hsa049111.03885954
63Serotonergic synapse_Homo sapiens_hsa047261.03286797
64Protein export_Homo sapiens_hsa030601.01556863
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.99944519
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98388165
67Retinol metabolism_Homo sapiens_hsa008300.97178715
68Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95237599
69Sphingolipid metabolism_Homo sapiens_hsa006000.94719294
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92523279
71Ovarian steroidogenesis_Homo sapiens_hsa049130.88512310
72Lysine degradation_Homo sapiens_hsa003100.87138972
73Fatty acid metabolism_Homo sapiens_hsa012120.84535135
74RNA degradation_Homo sapiens_hsa030180.81142768
75Vitamin digestion and absorption_Homo sapiens_hsa049770.80592464
76Gastric acid secretion_Homo sapiens_hsa049710.79350032
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78578787
78One carbon pool by folate_Homo sapiens_hsa006700.77032557
79Fatty acid elongation_Homo sapiens_hsa000620.76605391
80Primary immunodeficiency_Homo sapiens_hsa053400.75824754
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75157962
82Bile secretion_Homo sapiens_hsa049760.73789344
83Arachidonic acid metabolism_Homo sapiens_hsa005900.70772693
84Basal cell carcinoma_Homo sapiens_hsa052170.69283432
85Salivary secretion_Homo sapiens_hsa049700.69199944
86Dorso-ventral axis formation_Homo sapiens_hsa043200.68448181
87Platelet activation_Homo sapiens_hsa046110.67769956
88Amphetamine addiction_Homo sapiens_hsa050310.65846438
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65411195
90Fat digestion and absorption_Homo sapiens_hsa049750.64480297
91Fatty acid biosynthesis_Homo sapiens_hsa000610.63276843
92Tyrosine metabolism_Homo sapiens_hsa003500.62073460
93Regulation of autophagy_Homo sapiens_hsa041400.61020163
94Alzheimers disease_Homo sapiens_hsa050100.60134826
95Focal adhesion_Homo sapiens_hsa045100.59718017
96Starch and sucrose metabolism_Homo sapiens_hsa005000.59654435
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59309693
98Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.58244374
99Huntingtons disease_Homo sapiens_hsa050160.57983137
100DNA replication_Homo sapiens_hsa030300.57227412
101Metabolic pathways_Homo sapiens_hsa011000.56878515
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53399617
103Hedgehog signaling pathway_Homo sapiens_hsa043400.51724387
104Cocaine addiction_Homo sapiens_hsa050300.49941390
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49304525
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48712899
107Purine metabolism_Homo sapiens_hsa002300.47683869
108Thyroid cancer_Homo sapiens_hsa052160.47240172
109Dopaminergic synapse_Homo sapiens_hsa047280.45999559
110cAMP signaling pathway_Homo sapiens_hsa040240.45652804
111Glycerolipid metabolism_Homo sapiens_hsa005610.44755622
112Intestinal immune network for IgA production_Homo sapiens_hsa046720.40346006
113Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38888488
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37988587
115Drug metabolism - other enzymes_Homo sapiens_hsa009830.37935472
116Vibrio cholerae infection_Homo sapiens_hsa051100.37459651
117Carbon metabolism_Homo sapiens_hsa012000.36760085
118Renin-angiotensin system_Homo sapiens_hsa046140.36235370
119N-Glycan biosynthesis_Homo sapiens_hsa005100.35247367
1202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34613652
121Inositol phosphate metabolism_Homo sapiens_hsa005620.33918715
122Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32789237
123Cholinergic synapse_Homo sapiens_hsa047250.31756504
124Calcium signaling pathway_Homo sapiens_hsa040200.30510562
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29999437
126Primary bile acid biosynthesis_Homo sapiens_hsa001200.29904568
127cGMP-PKG signaling pathway_Homo sapiens_hsa040220.27597602
128Steroid hormone biosynthesis_Homo sapiens_hsa001400.27170522
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.26562696
130Small cell lung cancer_Homo sapiens_hsa052220.25189998
131Thyroid hormone synthesis_Homo sapiens_hsa049180.25034486
132Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23717883
133ABC transporters_Homo sapiens_hsa020100.20494662
134Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.20324813
135Proteoglycans in cancer_Homo sapiens_hsa052050.19521527
136Caffeine metabolism_Homo sapiens_hsa002320.19423898
137Taste transduction_Homo sapiens_hsa047420.18346876
138Mineral absorption_Homo sapiens_hsa049780.18077771
139Cardiac muscle contraction_Homo sapiens_hsa042600.16651356
140Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16189548
141Phagosome_Homo sapiens_hsa041450.14721395
142Lysosome_Homo sapiens_hsa041420.13246453
143AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.12483305
144Pyrimidine metabolism_Homo sapiens_hsa002400.12420637
145Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.12364377
146Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.11269370
147Non-homologous end-joining_Homo sapiens_hsa034500.08422342
148Pentose phosphate pathway_Homo sapiens_hsa000300.08394638
149Cell cycle_Homo sapiens_hsa041100.08261795
150Choline metabolism in cancer_Homo sapiens_hsa052310.06125082
151Circadian rhythm_Homo sapiens_hsa047100.04830249

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