

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | synaptic vesicle exocytosis (GO:0016079) | 5.50899832 |
| 2 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.31375688 |
| 3 | vocalization behavior (GO:0071625) | 4.91034813 |
| 4 | neuron cell-cell adhesion (GO:0007158) | 4.84795053 |
| 5 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 4.81258587 |
| 6 | synaptic vesicle maturation (GO:0016188) | 4.78277880 |
| 7 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 4.70544918 |
| 8 | glutamate secretion (GO:0014047) | 4.66801712 |
| 9 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.63089202 |
| 10 | protein localization to synapse (GO:0035418) | 4.58624290 |
| 11 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 4.54090729 |
| 12 | neuronal action potential propagation (GO:0019227) | 4.53561555 |
| 13 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.37540182 |
| 14 | locomotory exploration behavior (GO:0035641) | 4.36669674 |
| 15 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 4.29337902 |
| 16 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.23232081 |
| 17 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 4.19662825 |
| 18 | neurotransmitter secretion (GO:0007269) | 4.19390096 |
| 19 | neurotransmitter-gated ion channel clustering (GO:0072578) | 4.18958046 |
| 20 | neuromuscular synaptic transmission (GO:0007274) | 4.10594732 |
| 21 | regulation of synaptic vesicle transport (GO:1902803) | 4.07372483 |
| 22 | neuron-neuron synaptic transmission (GO:0007270) | 3.94179095 |
| 23 | glutamate receptor signaling pathway (GO:0007215) | 3.94141221 |
| 24 | synaptic transmission, glutamatergic (GO:0035249) | 3.93417398 |
| 25 | gamma-aminobutyric acid transport (GO:0015812) | 3.82916437 |
| 26 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.81879446 |
| 27 | L-amino acid import (GO:0043092) | 3.80389402 |
| 28 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.77380276 |
| 29 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.73469334 |
| 30 | presynaptic membrane assembly (GO:0097105) | 3.70931986 |
| 31 | positive regulation of neurotransmitter secretion (GO:0001956) | 3.68425820 |
| 32 | amino acid import (GO:0043090) | 3.68192338 |
| 33 | positive regulation of dendritic spine development (GO:0060999) | 3.67940704 |
| 34 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.66656823 |
| 35 | presynaptic membrane organization (GO:0097090) | 3.57396992 |
| 36 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.56914068 |
| 37 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.55692546 |
| 38 | neurotransmitter transport (GO:0006836) | 3.54492131 |
| 39 | sodium ion export (GO:0071436) | 3.53228289 |
| 40 | regulation of synapse structural plasticity (GO:0051823) | 3.52950343 |
| 41 | exploration behavior (GO:0035640) | 3.52453156 |
| 42 | transmission of nerve impulse (GO:0019226) | 3.52337549 |
| 43 | establishment of mitochondrion localization (GO:0051654) | 3.49603569 |
| 44 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.48615946 |
| 45 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.46402793 |
| 46 | synaptic vesicle endocytosis (GO:0048488) | 3.44666935 |
| 47 | proline transport (GO:0015824) | 3.41952047 |
| 48 | cellular potassium ion homeostasis (GO:0030007) | 3.41531499 |
| 49 | neuronal ion channel clustering (GO:0045161) | 3.41184613 |
| 50 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.39208493 |
| 51 | neuron recognition (GO:0008038) | 3.37173800 |
| 52 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.36258688 |
| 53 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.35809725 |
| 54 | regulation of postsynaptic membrane potential (GO:0060078) | 3.33843704 |
| 55 | long-term synaptic potentiation (GO:0060291) | 3.33128431 |
| 56 | calcium ion-dependent exocytosis (GO:0017156) | 3.32567003 |
| 57 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.30713223 |
| 58 | positive regulation of membrane potential (GO:0045838) | 3.30066160 |
| 59 | postsynaptic membrane organization (GO:0001941) | 3.29809189 |
| 60 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.28651722 |
| 61 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.28372371 |
| 62 | regulation of neurotransmitter secretion (GO:0046928) | 3.27430749 |
| 63 | regulation of neurotransmitter levels (GO:0001505) | 3.26264012 |
| 64 | long-term memory (GO:0007616) | 3.25660882 |
| 65 | dendritic spine organization (GO:0097061) | 3.24068950 |
| 66 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.20570106 |
| 67 | positive regulation of synapse assembly (GO:0051965) | 3.19616109 |
| 68 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 3.17013095 |
| 69 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.14857188 |
| 70 | membrane depolarization during action potential (GO:0086010) | 3.14806992 |
| 71 | cerebellar granule cell differentiation (GO:0021707) | 3.14593626 |
| 72 | regulation of respiratory gaseous exchange (GO:0043576) | 3.13720121 |
| 73 | regulation of respiratory system process (GO:0044065) | 3.13155779 |
| 74 | positive regulation of synapse maturation (GO:0090129) | 3.13023146 |
| 75 | urinary tract smooth muscle contraction (GO:0014848) | 3.12950644 |
| 76 | membrane hyperpolarization (GO:0060081) | 3.12624447 |
| 77 | acidic amino acid transport (GO:0015800) | 3.12284964 |
| 78 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 3.11455474 |
| 79 | layer formation in cerebral cortex (GO:0021819) | 3.08637735 |
| 80 | regulation of neurotransmitter transport (GO:0051588) | 3.08406409 |
| 81 | regulation of synaptic plasticity (GO:0048167) | 3.07713698 |
| 82 | membrane depolarization (GO:0051899) | 3.07278077 |
| 83 | pyrimidine nucleobase catabolic process (GO:0006208) | 3.06604978 |
| 84 | regulation of vesicle fusion (GO:0031338) | 3.06534271 |
| 85 | cellular response to ATP (GO:0071318) | 3.05627023 |
| 86 | regulation of synapse maturation (GO:0090128) | 3.05109384 |
| 87 | neuromuscular process controlling posture (GO:0050884) | 3.04417490 |
| 88 | dendritic spine morphogenesis (GO:0060997) | 3.03806000 |
| 89 | adult walking behavior (GO:0007628) | 3.02534565 |
| 90 | axon ensheathment in central nervous system (GO:0032291) | 3.01718446 |
| 91 | central nervous system myelination (GO:0022010) | 3.01718446 |
| 92 | response to histamine (GO:0034776) | 3.01117387 |
| 93 | neuromuscular process controlling balance (GO:0050885) | 2.98215919 |
| 94 | synapse assembly (GO:0007416) | 2.97266571 |
| 95 | establishment of synaptic vesicle localization (GO:0097480) | 2.97209866 |
| 96 | synaptic vesicle transport (GO:0048489) | 2.97209866 |
| 97 | ATP hydrolysis coupled proton transport (GO:0015991) | 2.96624891 |
| 98 | energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988) | 2.96624891 |
| 99 | regulation of dendritic spine development (GO:0060998) | 2.96435054 |
| 100 | response to auditory stimulus (GO:0010996) | 2.96309094 |
| 101 | regulation of dendritic spine morphogenesis (GO:0061001) | 2.95527325 |
| 102 | axonal fasciculation (GO:0007413) | 2.94209510 |
| 103 | synaptic transmission (GO:0007268) | 2.94006550 |
| 104 | auditory behavior (GO:0031223) | 2.92651248 |
| 105 | neurofilament cytoskeleton organization (GO:0060052) | 2.90216169 |
| 106 | regulation of voltage-gated calcium channel activity (GO:1901385) | 2.90095752 |
| 107 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 2.89982236 |
| 108 | positive regulation of synaptic transmission (GO:0050806) | 2.88853626 |
| 109 | dicarboxylic acid transport (GO:0006835) | 2.88090840 |
| 110 | transferrin transport (GO:0033572) | 2.87751471 |
| 111 | learning (GO:0007612) | 2.87597056 |
| 112 | striatum development (GO:0021756) | 2.86501549 |
| 113 | activation of protein kinase A activity (GO:0034199) | 2.86137333 |
| 114 | regulation of dendrite morphogenesis (GO:0048814) | 2.85166272 |
| 115 | regulation of synaptic transmission, GABAergic (GO:0032228) | 2.85152386 |
| 116 | regulation of synaptic transmission (GO:0050804) | 2.84575815 |
| 117 | behavioral response to cocaine (GO:0048148) | 2.83951315 |
| 118 | positive regulation of neurotransmitter transport (GO:0051590) | 2.83382465 |
| 119 | potassium ion homeostasis (GO:0055075) | 2.82763874 |
| 120 | regulation of glutamate secretion (GO:0014048) | 2.81178839 |
| 121 | cell migration in hindbrain (GO:0021535) | 2.81024284 |
| 122 | central nervous system projection neuron axonogenesis (GO:0021952) | 2.79352748 |
| 123 | signal release (GO:0023061) | 2.78521370 |
| 124 | negative regulation of amyloid precursor protein catabolic process (GO:1902992) | 2.77076937 |
| 125 | mating behavior (GO:0007617) | 2.75311877 |
| 126 | startle response (GO:0001964) | 2.75226848 |
| 127 | mechanosensory behavior (GO:0007638) | 2.75142478 |
| 128 | dendrite morphogenesis (GO:0048813) | 2.75099803 |
| 129 | negative regulation of dendrite morphogenesis (GO:0050774) | 2.73575758 |
| 130 | detection of calcium ion (GO:0005513) | 2.73048192 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.63730320 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 4.09616335 |
| 3 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.16766921 |
| 4 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 3.08156190 |
| 5 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.98091766 |
| 6 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.71129270 |
| 7 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.59748191 |
| 8 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.59748191 |
| 9 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.58446394 |
| 10 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.58138499 |
| 11 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.56664992 |
| 12 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.49616991 |
| 13 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.48107904 |
| 14 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.47056550 |
| 15 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.46787746 |
| 16 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.36585228 |
| 17 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.36315044 |
| 18 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.25719376 |
| 19 | * CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 2.25334295 |
| 20 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.24810350 |
| 21 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.21351406 |
| 22 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.19958817 |
| 23 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.18794407 |
| 24 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.18308377 |
| 25 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.04796217 |
| 26 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.97620953 |
| 27 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.97080491 |
| 28 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.96196902 |
| 29 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.95694537 |
| 30 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.87514456 |
| 31 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.87326943 |
| 32 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.85659406 |
| 33 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.82835719 |
| 34 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.77464137 |
| 35 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.77020921 |
| 36 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.73632458 |
| 37 | * P68_20966046_ChIP-Seq_HELA_Human | 1.73474656 |
| 38 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.72297092 |
| 39 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.69917867 |
| 40 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.67301919 |
| 41 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.63317168 |
| 42 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.60267938 |
| 43 | P300_19829295_ChIP-Seq_ESCs_Human | 1.59946399 |
| 44 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.54676329 |
| 45 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.51782273 |
| 46 | MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 1.49591599 |
| 47 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.48837476 |
| 48 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.47331139 |
| 49 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.45067973 |
| 50 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.44848633 |
| 51 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.43637763 |
| 52 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.38484230 |
| 53 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.38002581 |
| 54 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.37895695 |
| 55 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.37840823 |
| 56 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.36452350 |
| 57 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.34543200 |
| 58 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.34363474 |
| 59 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.34140115 |
| 60 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.33401088 |
| 61 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.33166300 |
| 62 | AR_25329375_ChIP-Seq_VCAP_Human | 1.32556854 |
| 63 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.32437306 |
| 64 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.31788341 |
| 65 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.31489067 |
| 66 | OCT4_19829295_ChIP-Seq_ESCs_Human | 1.30194557 |
| 67 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.27009306 |
| 68 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.26237404 |
| 69 | STAT3_23295773_ChIP-Seq_U87_Human | 1.24236396 |
| 70 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.23962860 |
| 71 | KDM2B_26808549_Chip-Seq_K562_Human | 1.22267457 |
| 72 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 1.21283625 |
| 73 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.20946778 |
| 74 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.20852555 |
| 75 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.20532352 |
| 76 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.19787794 |
| 77 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.19232986 |
| 78 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.15145503 |
| 79 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 1.14799101 |
| 80 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.14156977 |
| 81 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.13468694 |
| 82 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.13228772 |
| 83 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.12718047 |
| 84 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.12200915 |
| 85 | * E2F1_20622854_ChIP-Seq_HELA_Human | 1.12200784 |
| 86 | TP53_22127205_ChIP-Seq_IMR90_Human | 1.12054540 |
| 87 | FUS_26573619_Chip-Seq_HEK293_Human | 1.11749755 |
| 88 | CREB1_26743006_Chip-Seq_LNCaP_Human | 1.11702718 |
| 89 | TCF4_23295773_ChIP-Seq_U87_Human | 1.11326115 |
| 90 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.10013791 |
| 91 | TFAP2A_17053090_ChIP-ChIP_MCF-7_Human | 1.09932727 |
| 92 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.09410775 |
| 93 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.09330395 |
| 94 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.09225982 |
| 95 | PHF8_20622854_ChIP-Seq_HELA_Human | 1.08464947 |
| 96 | AR_19668381_ChIP-Seq_PC3_Human | 1.08311047 |
| 97 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.07987314 |
| 98 | * UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.07917591 |
| 99 | VDR_22108803_ChIP-Seq_LS180_Human | 1.06944610 |
| 100 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.06309108 |
| 101 | * NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse | 1.06008458 |
| 102 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.05411370 |
| 103 | * BCL6_27268052_Chip-Seq_Bcells_Human | 1.05373732 |
| 104 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.05287410 |
| 105 | * SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.05261448 |
| 106 | CTCF_20526341_ChIP-Seq_ESCs_Human | 1.05182585 |
| 107 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.04894473 |
| 108 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.04246377 |
| 109 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.04105277 |
| 110 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.03521985 |
| 111 | * BCOR_27268052_Chip-Seq_Bcells_Human | 1.03192255 |
| 112 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.02418400 |
| 113 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.02008270 |
| 114 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 1.01753570 |
| 115 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.01085843 |
| 116 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.00092946 |
| 117 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.99199063 |
| 118 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.97153416 |
| 119 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.97130866 |
| 120 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 0.96959225 |
| 121 | JUN_21703547_ChIP-Seq_K562_Human | 0.96187413 |
| 122 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.94325875 |
| 123 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.94320180 |
| 124 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.93611060 |
| 125 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.93209241 |
| 126 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 0.92943646 |
| 127 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 0.92537537 |
| 128 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.92488218 |
| 129 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 0.92164658 |
| 130 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.91605299 |
| 131 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.91605299 |
| 132 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.91165464 |
| 133 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.90005305 |
| 134 | * KLF4_19829295_ChIP-Seq_ESCs_Human | 0.89060328 |
| 135 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.88889814 |
| 136 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 0.88325967 |
| 137 | * KDM2B_26808549_Chip-Seq_DND41_Human | 0.87967236 |
| 138 | KDM2B_26808549_Chip-Seq_REH_Human | 0.85949097 |
| 139 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.85141521 |
| 140 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 0.84707302 |
| 141 | OCT4_20526341_ChIP-Seq_ESCs_Human | 0.84428901 |
| 142 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.84344659 |
| 143 | SA1_27219007_Chip-Seq_Bcells_Human | 0.83869414 |
| 144 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.83685712 |
| 145 | SOX9_26525672_Chip-Seq_HEART_Mouse | 0.82809334 |
| 146 | * ERA_21632823_ChIP-Seq_H3396_Human | 0.82595528 |
| 147 | RARA_24833708_ChIP-Seq_LIVER_Mouse | 0.82494999 |
| 148 | * FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.82361556 |
| 149 | * TP53_23651856_ChIP-Seq_MEFs_Mouse | 0.82165009 |
| 150 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 0.82063990 |
| 151 | JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse | 0.82021957 |
| 152 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.81757380 |
| 153 | * CBP_20019798_ChIP-Seq_JUKART_Human | 0.81442584 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 5.33733045 |
| 2 | MP0003880_abnormal_central_pattern | 4.64175886 |
| 3 | MP0003635_abnormal_synaptic_transmissio | 3.79006155 |
| 4 | MP0004270_analgesia | 3.41892031 |
| 5 | MP0009745_abnormal_behavioral_response | 3.28739824 |
| 6 | MP0001968_abnormal_touch/_nociception | 3.22959901 |
| 7 | MP0002064_seizures | 3.21038293 |
| 8 | MP0009046_muscle_twitch | 3.19943648 |
| 9 | MP0002063_abnormal_learning/memory/cond | 3.02320968 |
| 10 | MP0002822_catalepsy | 2.96675993 |
| 11 | MP0002736_abnormal_nociception_after | 2.84322863 |
| 12 | MP0002272_abnormal_nervous_system | 2.82242557 |
| 13 | MP0002735_abnormal_chemical_nociception | 2.78500128 |
| 14 | MP0002734_abnormal_mechanical_nocicepti | 2.76268797 |
| 15 | MP0002572_abnormal_emotion/affect_behav | 2.72101726 |
| 16 | MP0005423_abnormal_somatic_nervous | 2.56937451 |
| 17 | MP0001486_abnormal_startle_reflex | 2.50606897 |
| 18 | MP0001440_abnormal_grooming_behavior | 2.28800607 |
| 19 | MP0001501_abnormal_sleep_pattern | 2.28325739 |
| 20 | MP0002067_abnormal_sensory_capabilities | 2.15918159 |
| 21 | MP0001970_abnormal_pain_threshold | 2.14869882 |
| 22 | MP0006276_abnormal_autonomic_nervous | 2.14603021 |
| 23 | MP0002733_abnormal_thermal_nociception | 2.12756662 |
| 24 | MP0001529_abnormal_vocalization | 2.12105052 |
| 25 | MP0005646_abnormal_pituitary_gland | 1.84139037 |
| 26 | MP0005386_behavior/neurological_phenoty | 1.83710886 |
| 27 | MP0004924_abnormal_behavior | 1.83710886 |
| 28 | MP0008569_lethality_at_weaning | 1.83556356 |
| 29 | MP0002184_abnormal_innervation | 1.83241051 |
| 30 | MP0001984_abnormal_olfaction | 1.81323161 |
| 31 | MP0003329_amyloid_beta_deposits | 1.77398417 |
| 32 | MP0001905_abnormal_dopamine_level | 1.73282933 |
| 33 | MP0000778_abnormal_nervous_system | 1.73237413 |
| 34 | MP0002557_abnormal_social/conspecific_i | 1.68994439 |
| 35 | MP0004142_abnormal_muscle_tone | 1.66052542 |
| 36 | MP0004858_abnormal_nervous_system | 1.58274961 |
| 37 | MP0004811_abnormal_neuron_physiology | 1.55923802 |
| 38 | MP0003879_abnormal_hair_cell | 1.53178317 |
| 39 | MP0003122_maternal_imprinting | 1.52410241 |
| 40 | MP0000955_abnormal_spinal_cord | 1.49736798 |
| 41 | MP0009780_abnormal_chondrocyte_physiolo | 1.49273701 |
| 42 | MP0002882_abnormal_neuron_morphology | 1.45782942 |
| 43 | MP0001502_abnormal_circadian_rhythm | 1.43100207 |
| 44 | MP0002066_abnormal_motor_capabilities/c | 1.41225834 |
| 45 | MP0003787_abnormal_imprinting | 1.40881853 |
| 46 | MP0005645_abnormal_hypothalamus_physiol | 1.39965596 |
| 47 | MP0005551_abnormal_eye_electrophysiolog | 1.33028974 |
| 48 | MP0002909_abnormal_adrenal_gland | 1.33019387 |
| 49 | MP0003633_abnormal_nervous_system | 1.29929912 |
| 50 | MP0001188_hyperpigmentation | 1.29002230 |
| 51 | MP0002229_neurodegeneration | 1.21269440 |
| 52 | MP0004885_abnormal_endolymph | 1.21083094 |
| 53 | MP0005410_abnormal_fertilization | 1.19377422 |
| 54 | MP0000920_abnormal_myelination | 1.17386575 |
| 55 | MP0002837_dystrophic_cardiac_calcinosis | 1.17351390 |
| 56 | MP0005174_abnormal_tail_pigmentation | 1.16485839 |
| 57 | MP0004742_abnormal_vestibular_system | 1.15745521 |
| 58 | MP0003631_nervous_system_phenotype | 1.14679351 |
| 59 | MP0010386_abnormal_urinary_bladder | 1.14346649 |
| 60 | MP0003634_abnormal_glial_cell | 1.07801278 |
| 61 | MP0000751_myopathy | 1.06491169 |
| 62 | MP0001986_abnormal_taste_sensitivity | 1.03189832 |
| 63 | MP0003690_abnormal_glial_cell | 1.03161404 |
| 64 | MP0002152_abnormal_brain_morphology | 1.01594671 |
| 65 | MP0008872_abnormal_physiological_respon | 1.00914272 |
| 66 | MP0002876_abnormal_thyroid_physiology | 1.00218420 |
| 67 | MP0002090_abnormal_vision | 0.99292974 |
| 68 | MP0001963_abnormal_hearing_physiology | 0.98014246 |
| 69 | MP0004145_abnormal_muscle_electrophysio | 0.97595968 |
| 70 | MP0004147_increased_porphyrin_level | 0.96404144 |
| 71 | MP0002069_abnormal_eating/drinking_beha | 0.95718354 |
| 72 | MP0002102_abnormal_ear_morphology | 0.94581055 |
| 73 | MP0002638_abnormal_pupillary_reflex | 0.93489424 |
| 74 | MP0008877_abnormal_DNA_methylation | 0.92765204 |
| 75 | MP0003121_genomic_imprinting | 0.92191954 |
| 76 | MP0002752_abnormal_somatic_nervous | 0.91916096 |
| 77 | MP0003632_abnormal_nervous_system | 0.88886153 |
| 78 | MP0005171_absent_coat_pigmentation | 0.86061309 |
| 79 | MP0003183_abnormal_peptide_metabolism | 0.85024260 |
| 80 | MP0004130_abnormal_muscle_cell | 0.84587111 |
| 81 | MP0000604_amyloidosis | 0.82962435 |
| 82 | MP0004085_abnormal_heartbeat | 0.81496405 |
| 83 | MP0000631_abnormal_neuroendocrine_gland | 0.81028913 |
| 84 | MP0008874_decreased_physiological_sensi | 0.79640558 |
| 85 | MP0005535_abnormal_body_temperature | 0.78551560 |
| 86 | MP0000015_abnormal_ear_pigmentation | 0.78255364 |
| 87 | MP0002653_abnormal_ependyma_morphology | 0.74734554 |
| 88 | MP0004215_abnormal_myocardial_fiber | 0.74130367 |
| 89 | MP0006072_abnormal_retinal_apoptosis | 0.73351206 |
| 90 | MP0005083_abnormal_biliary_tract | 0.72670601 |
| 91 | MP0005409_darkened_coat_color | 0.71568726 |
| 92 | MP0000013_abnormal_adipose_tissue | 0.70351304 |
| 93 | MP0005499_abnormal_olfactory_system | 0.69529169 |
| 94 | MP0005394_taste/olfaction_phenotype | 0.69529169 |
| 95 | MP0001177_atelectasis | 0.67882292 |
| 96 | MP0004043_abnormal_pH_regulation | 0.67863407 |
| 97 | MP0001664_abnormal_digestion | 0.67466707 |
| 98 | MP0001485_abnormal_pinna_reflex | 0.67418743 |
| 99 | MP0003137_abnormal_impulse_conducting | 0.66957536 |
| 100 | MP0000569_abnormal_digit_pigmentation | 0.65536188 |
| 101 | MP0003698_abnormal_male_reproductive | 0.65464225 |
| 102 | MP0005253_abnormal_eye_physiology | 0.61507409 |
| 103 | MP0001299_abnormal_eye_distance/ | 0.59996910 |
| 104 | MP0008789_abnormal_olfactory_epithelium | 0.59452021 |
| 105 | MP0000026_abnormal_inner_ear | 0.58903380 |
| 106 | MP0010768_mortality/aging | 0.57938312 |
| 107 | MP0004484_altered_response_of | 0.56479148 |
| 108 | MP0004036_abnormal_muscle_relaxation | 0.56416739 |
| 109 | MP0001943_abnormal_respiration | 0.56258896 |
| 110 | MP0002928_abnormal_bile_duct | 0.55053209 |
| 111 | MP0003861_abnormal_nervous_system | 0.53955980 |
| 112 | MP0001348_abnormal_lacrimal_gland | 0.53843866 |
| 113 | MP0004133_heterotaxia | 0.52525894 |
| 114 | MP0010769_abnormal_survival | 0.50014975 |
| 115 | MP0002082_postnatal_lethality | 0.49944238 |
| 116 | MP0010770_preweaning_lethality | 0.49944238 |
| 117 | MP0005623_abnormal_meninges_morphology | 0.49297636 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 7.89868839 |
| 2 | Myokymia (HP:0002411) | 6.44877356 |
| 3 | Focal seizures (HP:0007359) | 5.47480048 |
| 4 | Atonic seizures (HP:0010819) | 5.20215182 |
| 5 | Epileptic encephalopathy (HP:0200134) | 5.00455672 |
| 6 | Febrile seizures (HP:0002373) | 4.77433764 |
| 7 | Visual hallucinations (HP:0002367) | 4.74273997 |
| 8 | Absence seizures (HP:0002121) | 4.39590223 |
| 9 | Progressive cerebellar ataxia (HP:0002073) | 4.14269912 |
| 10 | Dialeptic seizures (HP:0011146) | 4.12932502 |
| 11 | Annular pancreas (HP:0001734) | 4.10277340 |
| 12 | Generalized tonic-clonic seizures (HP:0002069) | 3.81272272 |
| 13 | Action tremor (HP:0002345) | 3.41328284 |
| 14 | Hyperventilation (HP:0002883) | 3.39513599 |
| 15 | Supranuclear gaze palsy (HP:0000605) | 3.29108148 |
| 16 | Broad-based gait (HP:0002136) | 3.25178001 |
| 17 | Pheochromocytoma (HP:0002666) | 3.15868619 |
| 18 | Gaze-evoked nystagmus (HP:0000640) | 3.08083110 |
| 19 | Abnormal eating behavior (HP:0100738) | 3.07378599 |
| 20 | Ankle clonus (HP:0011448) | 3.04483092 |
| 21 | Dysdiadochokinesis (HP:0002075) | 3.04318470 |
| 22 | Dysmetria (HP:0001310) | 3.02428025 |
| 23 | Rib fusion (HP:0000902) | 2.99440479 |
| 24 | Truncal ataxia (HP:0002078) | 2.90581896 |
| 25 | Anxiety (HP:0000739) | 2.89724876 |
| 26 | Limb dystonia (HP:0002451) | 2.89291699 |
| 27 | Neuroendocrine neoplasm (HP:0100634) | 2.88631985 |
| 28 | Progressive inability to walk (HP:0002505) | 2.83932916 |
| 29 | Depression (HP:0000716) | 2.82898578 |
| 30 | Attenuation of retinal blood vessels (HP:0007843) | 2.80581388 |
| 31 | Scanning speech (HP:0002168) | 2.80254465 |
| 32 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.76113637 |
| 33 | Amblyopia (HP:0000646) | 2.71806416 |
| 34 | Ulnar claw (HP:0001178) | 2.71055150 |
| 35 | Polyphagia (HP:0002591) | 2.70930113 |
| 36 | Diplopia (HP:0000651) | 2.66337747 |
| 37 | Abnormality of binocular vision (HP:0011514) | 2.66337747 |
| 38 | Cerebral hypomyelination (HP:0006808) | 2.65161204 |
| 39 | Spastic gait (HP:0002064) | 2.65059873 |
| 40 | Neurofibrillary tangles (HP:0002185) | 2.59174764 |
| 41 | Abnormality of the corticospinal tract (HP:0002492) | 2.56661902 |
| 42 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 2.55878683 |
| 43 | Abnormal hair whorl (HP:0010721) | 2.55415804 |
| 44 | Epileptiform EEG discharges (HP:0011182) | 2.54959755 |
| 45 | Poor eye contact (HP:0000817) | 2.52750770 |
| 46 | Congenital stationary night blindness (HP:0007642) | 2.52398271 |
| 47 | Gait imbalance (HP:0002141) | 2.51658473 |
| 48 | Termporal pattern (HP:0011008) | 2.50324725 |
| 49 | Insidious onset (HP:0003587) | 2.50324725 |
| 50 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.46679772 |
| 51 | Hemiparesis (HP:0001269) | 2.45584598 |
| 52 | EEG with generalized epileptiform discharges (HP:0011198) | 2.44303182 |
| 53 | Postural instability (HP:0002172) | 2.38775727 |
| 54 | Bony spicule pigmentary retinopathy (HP:0007737) | 2.35780650 |
| 55 | Abnormal social behavior (HP:0012433) | 2.33709625 |
| 56 | Impaired social interactions (HP:0000735) | 2.33709625 |
| 57 | Cerebral inclusion bodies (HP:0100314) | 2.33597998 |
| 58 | Choroideremia (HP:0001139) | 2.32747960 |
| 59 | Failure to thrive in infancy (HP:0001531) | 2.32470377 |
| 60 | Excessive salivation (HP:0003781) | 2.29742708 |
| 61 | Drooling (HP:0002307) | 2.29742708 |
| 62 | Urinary urgency (HP:0000012) | 2.28414985 |
| 63 | Turricephaly (HP:0000262) | 2.28400773 |
| 64 | Morphological abnormality of the pyramidal tract (HP:0002062) | 2.28206307 |
| 65 | Clonus (HP:0002169) | 2.27368449 |
| 66 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 2.25858743 |
| 67 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 2.25858743 |
| 68 | Papilledema (HP:0001085) | 2.25465627 |
| 69 | Hypsarrhythmia (HP:0002521) | 2.25124564 |
| 70 | Mutism (HP:0002300) | 2.21829829 |
| 71 | Psychosis (HP:0000709) | 2.21097410 |
| 72 | Torticollis (HP:0000473) | 2.20409950 |
| 73 | Peripheral hypomyelination (HP:0007182) | 2.19986289 |
| 74 | Congenital primary aphakia (HP:0007707) | 2.18952070 |
| 75 | Acute necrotizing encephalopathy (HP:0006965) | 2.18906531 |
| 76 | Hypothermia (HP:0002045) | 2.17564718 |
| 77 | Bradykinesia (HP:0002067) | 2.17085829 |
| 78 | Intention tremor (HP:0002080) | 2.16170363 |
| 79 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.15122396 |
| 80 | Progressive microcephaly (HP:0000253) | 2.14968468 |
| 81 | Specific learning disability (HP:0001328) | 2.13244274 |
| 82 | Fetal akinesia sequence (HP:0001989) | 2.12321385 |
| 83 | Medial flaring of the eyebrow (HP:0010747) | 2.09909313 |
| 84 | Absent speech (HP:0001344) | 2.09481357 |
| 85 | Focal dystonia (HP:0004373) | 2.09285377 |
| 86 | Inability to walk (HP:0002540) | 2.09064066 |
| 87 | Generalized myoclonic seizures (HP:0002123) | 2.07689726 |
| 88 | Sensory axonal neuropathy (HP:0003390) | 2.07499417 |
| 89 | Poor suck (HP:0002033) | 2.07079511 |
| 90 | Amyotrophic lateral sclerosis (HP:0007354) | 2.07029990 |
| 91 | Lower limb muscle weakness (HP:0007340) | 2.05345121 |
| 92 | Nephrogenic diabetes insipidus (HP:0009806) | 2.03975643 |
| 93 | Retinal dysplasia (HP:0007973) | 2.02232320 |
| 94 | Progressive macrocephaly (HP:0004481) | 2.01820359 |
| 95 | Blue irides (HP:0000635) | 2.00480576 |
| 96 | Chronic hepatic failure (HP:0100626) | 1.98087621 |
| 97 | Hypoplasia of the brainstem (HP:0002365) | 1.97036875 |
| 98 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 1.97036875 |
| 99 | Genital tract atresia (HP:0001827) | 1.96095033 |
| 100 | Megalencephaly (HP:0001355) | 1.95964366 |
| 101 | Hemiplegia (HP:0002301) | 1.95962738 |
| 102 | Dyskinesia (HP:0100660) | 1.95036631 |
| 103 | Protruding tongue (HP:0010808) | 1.94865148 |
| 104 | Status epilepticus (HP:0002133) | 1.93480298 |
| 105 | Craniofacial dystonia (HP:0012179) | 1.92122910 |
| 106 | Esotropia (HP:0000565) | 1.92108243 |
| 107 | Poikiloderma (HP:0001029) | 1.91738957 |
| 108 | Postural tremor (HP:0002174) | 1.91246308 |
| 109 | Agitation (HP:0000713) | 1.91074666 |
| 110 | Vaginal atresia (HP:0000148) | 1.91062619 |
| 111 | Narrow nasal bridge (HP:0000446) | 1.90834882 |
| 112 | Genetic anticipation (HP:0003743) | 1.90725695 |
| 113 | Intellectual disability, severe (HP:0010864) | 1.90695974 |
| 114 | Gait ataxia (HP:0002066) | 1.90665146 |
| 115 | Spastic tetraplegia (HP:0002510) | 1.90473678 |
| 116 | Delusions (HP:0000746) | 1.89071777 |
| 117 | Rapidly progressive (HP:0003678) | 1.88661071 |
| 118 | Incomplete penetrance (HP:0003829) | 1.87665721 |
| 119 | Akinesia (HP:0002304) | 1.87569937 |
| 120 | Facial hemangioma (HP:0000329) | 1.87293981 |
| 121 | Impaired smooth pursuit (HP:0007772) | 1.86166792 |
| 122 | Decreased central vision (HP:0007663) | 1.85906603 |
| 123 | Chorioretinal atrophy (HP:0000533) | 1.85119441 |
| 124 | Rigidity (HP:0002063) | 1.83450387 |
| 125 | Neuronal loss in central nervous system (HP:0002529) | 1.83433952 |
| 126 | Impaired vibratory sensation (HP:0002495) | 1.82988577 |
| 127 | Short chin (HP:0000331) | 1.81327585 |
| 128 | Hypoventilation (HP:0002791) | 1.80195298 |
| 129 | Testicular atrophy (HP:0000029) | 1.80096618 |
| 130 | Neonatal onset (HP:0003623) | 1.79282417 |
| 131 | Dyschromatopsia (HP:0007641) | 1.78881243 |
| 132 | Abnormality of the lower motor neuron (HP:0002366) | 1.76791964 |
| 133 | Abnormality of ocular smooth pursuit (HP:0000617) | 1.75462098 |
| 134 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 1.71919065 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NTRK3 | 3.95542107 |
| 2 | CASK | 3.56579836 |
| 3 | EPHA4 | 3.40106827 |
| 4 | MAP3K4 | 3.12485578 |
| 5 | MAP2K7 | 2.95863660 |
| 6 | MAP3K9 | 2.77362863 |
| 7 | MAP3K12 | 2.56705753 |
| 8 | MARK1 | 2.50743278 |
| 9 | MAP3K11 | 2.43934459 |
| 10 | PRPF4B | 2.38331886 |
| 11 | MINK1 | 2.32684208 |
| 12 | DAPK2 | 2.12431934 |
| 13 | NTRK2 | 2.11119958 |
| 14 | TESK2 | 2.01529012 |
| 15 | MAP2K4 | 1.89325106 |
| 16 | GRK5 | 1.88601142 |
| 17 | PAK6 | 1.86836191 |
| 18 | CDK19 | 1.85683224 |
| 19 | TNIK | 1.79346694 |
| 20 | MAP4K2 | 1.70649062 |
| 21 | MAPK15 | 1.68733857 |
| 22 | PLK2 | 1.67060444 |
| 23 | NTRK1 | 1.63290234 |
| 24 | OXSR1 | 1.61055458 |
| 25 | MAPK13 | 1.55707151 |
| 26 | ARAF | 1.53567786 |
| 27 | KSR2 | 1.51764596 |
| 28 | CDK5 | 1.43220359 |
| 29 | RIPK4 | 1.40724879 |
| 30 | DAPK1 | 1.35450367 |
| 31 | CAMKK2 | 1.33798808 |
| 32 | PNCK | 1.32964034 |
| 33 | SGK494 | 1.27234891 |
| 34 | SGK223 | 1.27234891 |
| 35 | KSR1 | 1.27027220 |
| 36 | PHKG2 | 1.26515075 |
| 37 | PHKG1 | 1.26515075 |
| 38 | UHMK1 | 1.26233568 |
| 39 | FES | 1.22796054 |
| 40 | BCKDK | 1.22645583 |
| 41 | PDK2 | 1.20325644 |
| 42 | PRKCG | 1.18769076 |
| 43 | CAMKK1 | 1.17851005 |
| 44 | PRKD3 | 1.15504273 |
| 45 | TLK1 | 1.12819618 |
| 46 | NME1 | 1.11375400 |
| 47 | CAMK2A | 1.09009596 |
| 48 | PIM2 | 1.08690962 |
| 49 | CAMK2B | 1.06013837 |
| 50 | BLK | 1.04566343 |
| 51 | SIK3 | 1.03467728 |
| 52 | SIK2 | 0.98234825 |
| 53 | CAMK1D | 0.97750178 |
| 54 | CSNK1A1L | 0.96757990 |
| 55 | CDK18 | 0.95047766 |
| 56 | RAF1 | 0.94290409 |
| 57 | STK39 | 0.92552855 |
| 58 | MAP3K2 | 0.92131598 |
| 59 | CDK14 | 0.90470911 |
| 60 | CDK15 | 0.89550552 |
| 61 | SGK2 | 0.88174046 |
| 62 | PTK2B | 0.86328410 |
| 63 | DYRK2 | 0.83495754 |
| 64 | TYRO3 | 0.82635519 |
| 65 | BCR | 0.81264367 |
| 66 | MAP3K13 | 0.80702817 |
| 67 | AKT3 | 0.80208980 |
| 68 | PRKCE | 0.79614858 |
| 69 | CDK11A | 0.77620607 |
| 70 | PRKCH | 0.76806602 |
| 71 | TNK2 | 0.76791278 |
| 72 | CSNK1G2 | 0.75021253 |
| 73 | CAMK4 | 0.72786197 |
| 74 | FGR | 0.72766992 |
| 75 | STK38 | 0.72726593 |
| 76 | CAMK1 | 0.72398810 |
| 77 | LMTK2 | 0.72389735 |
| 78 | CAMK2D | 0.71295065 |
| 79 | CCNB1 | 0.69956850 |
| 80 | MAPKAPK5 | 0.69953629 |
| 81 | GRK7 | 0.69636299 |
| 82 | DYRK1A | 0.69162963 |
| 83 | MUSK | 0.67336261 |
| 84 | PAK3 | 0.67265700 |
| 85 | CAMK2G | 0.67103471 |
| 86 | DYRK1B | 0.66960031 |
| 87 | TAOK3 | 0.66441386 |
| 88 | PINK1 | 0.65357873 |
| 89 | PKN1 | 0.64677043 |
| 90 | MAPK12 | 0.64241305 |
| 91 | WNK1 | 0.63695031 |
| 92 | RET | 0.62187818 |
| 93 | ADRBK2 | 0.61980874 |
| 94 | STK11 | 0.59636381 |
| 95 | MARK2 | 0.58614210 |
| 96 | BMPR2 | 0.58541705 |
| 97 | LATS2 | 0.57437106 |
| 98 | SGK1 | 0.57236077 |
| 99 | MAPK10 | 0.54291532 |
| 100 | SGK3 | 0.54288779 |
| 101 | ZAK | 0.53658875 |
| 102 | ROCK2 | 0.53267481 |
| 103 | NEK6 | 0.49246793 |
| 104 | BRAF | 0.49216929 |
| 105 | CSNK1G3 | 0.47737817 |
| 106 | ADRBK1 | 0.46973772 |
| 107 | LIMK1 | 0.46657335 |
| 108 | CAMK1G | 0.46615512 |
| 109 | PRKAA1 | 0.46255061 |
| 110 | PDPK1 | 0.46020541 |
| 111 | TSSK6 | 0.45850309 |
| 112 | FER | 0.45457549 |
| 113 | WNK3 | 0.45357936 |
| 114 | FGFR2 | 0.45226203 |
| 115 | CSNK1D | 0.44751378 |
| 116 | PRKACA | 0.44077496 |
| 117 | MAPK8 | 0.43591221 |
| 118 | RPS6KA3 | 0.43038816 |
| 119 | WNK4 | 0.42205471 |
| 120 | PDK1 | 0.41554432 |
| 121 | GRK6 | 0.41021225 |
| 122 | TRIM28 | 0.40274889 |
| 123 | FYN | 0.39706934 |
| 124 | PRKCZ | 0.39398547 |
| 125 | DAPK3 | 0.38961825 |
| 126 | MAP2K1 | 0.38900973 |
| 127 | MAP3K5 | 0.38432770 |
| 128 | MAP3K1 | 0.36259535 |
| 129 | CSNK1G1 | 0.33515143 |
| 130 | GSK3B | 0.33066591 |
| 131 | PRKD1 | 0.32173611 |
| 132 | RPS6KA2 | 0.31929765 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 3.91754423 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.83570109 |
| 3 | GABAergic synapse_Homo sapiens_hsa04727 | 2.82381080 |
| 4 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.78615151 |
| 5 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 2.67110202 |
| 6 | Olfactory transduction_Homo sapiens_hsa04740 | 2.59879761 |
| 7 | Morphine addiction_Homo sapiens_hsa05032 | 2.58208523 |
| 8 | Circadian entrainment_Homo sapiens_hsa04713 | 2.52906122 |
| 9 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.47915863 |
| 10 | Long-term potentiation_Homo sapiens_hsa04720 | 2.27362291 |
| 11 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.23632956 |
| 12 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.09062763 |
| 13 | Salivary secretion_Homo sapiens_hsa04970 | 1.98404445 |
| 14 | Insulin secretion_Homo sapiens_hsa04911 | 1.94003569 |
| 15 | Taste transduction_Homo sapiens_hsa04742 | 1.91635349 |
| 16 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.89416069 |
| 17 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.80570154 |
| 18 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.75973995 |
| 19 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.74944581 |
| 20 | Long-term depression_Homo sapiens_hsa04730 | 1.66279164 |
| 21 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.65620758 |
| 22 | Renin secretion_Homo sapiens_hsa04924 | 1.61093516 |
| 23 | Cocaine addiction_Homo sapiens_hsa05030 | 1.60681870 |
| 24 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.60004028 |
| 25 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.57721575 |
| 26 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.51900439 |
| 27 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.48277939 |
| 28 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.40755702 |
| 29 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.37131648 |
| 30 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.35655000 |
| 31 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.32308426 |
| 32 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.31134825 |
| 33 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.29766837 |
| 34 | Alzheimers disease_Homo sapiens_hsa05010 | 1.27315545 |
| 35 | Parkinsons disease_Homo sapiens_hsa05012 | 1.27280934 |
| 36 | Sulfur relay system_Homo sapiens_hsa04122 | 1.24548203 |
| 37 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 1.21197375 |
| 38 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 1.18570194 |
| 39 | Gap junction_Homo sapiens_hsa04540 | 1.17725688 |
| 40 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.16824732 |
| 41 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.10083866 |
| 42 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.07675704 |
| 43 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.05348273 |
| 44 | Axon guidance_Homo sapiens_hsa04360 | 1.04716291 |
| 45 | Phototransduction_Homo sapiens_hsa04744 | 1.04239720 |
| 46 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.03136560 |
| 47 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.03120537 |
| 48 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.95305019 |
| 49 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.88455478 |
| 50 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.88448198 |
| 51 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.86982084 |
| 52 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.86874569 |
| 53 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.84427051 |
| 54 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.80746269 |
| 55 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.78947547 |
| 56 | Huntingtons disease_Homo sapiens_hsa05016 | 0.74683433 |
| 57 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.72852865 |
| 58 | Melanogenesis_Homo sapiens_hsa04916 | 0.72041421 |
| 59 | Glioma_Homo sapiens_hsa05214 | 0.69595945 |
| 60 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.66872491 |
| 61 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.64936513 |
| 62 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.63751204 |
| 63 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.63679855 |
| 64 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.62138064 |
| 65 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.61858630 |
| 66 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.61789479 |
| 67 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.58899669 |
| 68 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.58069420 |
| 69 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.58003056 |
| 70 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.56487938 |
| 71 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.56465045 |
| 72 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.56258626 |
| 73 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.55540053 |
| 74 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.55009212 |
| 75 | Phagosome_Homo sapiens_hsa04145 | 0.54587074 |
| 76 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.54584242 |
| 77 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.54024492 |
| 78 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.51993435 |
| 79 | Alcoholism_Homo sapiens_hsa05034 | 0.50885936 |
| 80 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.48998309 |
| 81 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.48754287 |
| 82 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.47939954 |
| 83 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.47753403 |
| 84 | Circadian rhythm_Homo sapiens_hsa04710 | 0.47710375 |
| 85 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.47479496 |
| 86 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.46022924 |
| 87 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.41930392 |
| 88 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.41373015 |
| 89 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.40786978 |
| 90 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.40712833 |
| 91 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.40205002 |
| 92 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.37774559 |
| 93 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.37406855 |
| 94 | * Endocytosis_Homo sapiens_hsa04144 | 0.36387068 |
| 95 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.36366698 |
| 96 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.36070097 |
| 97 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.36020501 |
| 98 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.35567300 |
| 99 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.34384990 |
| 100 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.34226942 |
| 101 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.33891063 |
| 102 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.33757910 |
| 103 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.31940259 |
| 104 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.31788848 |
| 105 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.31461077 |
| 106 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.30866878 |
| 107 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.30566371 |
| 108 | Bile secretion_Homo sapiens_hsa04976 | 0.30007657 |
| 109 | Prion diseases_Homo sapiens_hsa05020 | 0.29628793 |
| 110 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.28150541 |
| 111 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.27949862 |
| 112 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.27857457 |
| 113 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.27652252 |
| 114 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.27087132 |
| 115 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.25650127 |
| 116 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.25351188 |
| 117 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.25086402 |
| 118 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.24732268 |
| 119 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.22517436 |
| 120 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.22173430 |

