SNX5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein functions in endosomal sorting, the phosphoinositide-signaling pathway, and macropinocytosis. This gene may play a role in the tumorigenesis of papillary thyroid carcinoma. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1very-low-density lipoprotein particle assembly (GO:0034379)4.23683446
2mitotic sister chromatid segregation (GO:0000070)4.22651022
3DNA unwinding involved in DNA replication (GO:0006268)4.21915928
4nuclear pore organization (GO:0006999)4.06527007
5sister chromatid segregation (GO:0000819)4.06420833
6nuclear pore complex assembly (GO:0051292)3.92112435
7plasma lipoprotein particle assembly (GO:0034377)3.91807916
8ribosomal small subunit assembly (GO:0000028)3.90093024
9DNA strand elongation involved in DNA replication (GO:0006271)3.80254127
10protein localization to kinetochore (GO:0034501)3.73346218
11DNA replication initiation (GO:0006270)3.72711117
12ribosome assembly (GO:0042255)3.62434778
13folic acid-containing compound biosynthetic process (GO:0009396)3.61695098
14DNA strand elongation (GO:0022616)3.61372176
15regulation of centriole replication (GO:0046599)3.60662847
16mitotic nuclear envelope disassembly (GO:0007077)3.59551880
17maturation of SSU-rRNA (GO:0030490)3.56916174
18viral transcription (GO:0019083)3.47362323
19formation of translation preinitiation complex (GO:0001731)3.46669346
20translational termination (GO:0006415)3.46121532
21telomere maintenance via semi-conservative replication (GO:0032201)3.44291272
22IMP biosynthetic process (GO:0006188)3.43556397
23DNA replication-dependent nucleosome organization (GO:0034723)3.38808441
24DNA replication-dependent nucleosome assembly (GO:0006335)3.38808441
25protein-lipid complex assembly (GO:0065005)3.34125521
26regulation of sister chromatid cohesion (GO:0007063)3.31725876
27nuclear envelope disassembly (GO:0051081)3.30191795
28membrane disassembly (GO:0030397)3.30191795
29pore complex assembly (GO:0046931)3.28296650
30mitotic spindle checkpoint (GO:0071174)3.27510776
31DNA topological change (GO:0006265)3.25137463
32nucleobase biosynthetic process (GO:0046112)3.24868461
33protein localization to chromosome, centromeric region (GO:0071459)3.24406031
34regulation of centrosome cycle (GO:0046605)3.23459075
35negative regulation of chromosome segregation (GO:0051985)3.23431228
36spindle checkpoint (GO:0031577)3.21195400
37telomere maintenance via recombination (GO:0000722)3.21174051
38IMP metabolic process (GO:0046040)3.18726900
39ribosomal large subunit biogenesis (GO:0042273)3.18662155
40proline biosynthetic process (GO:0006561)3.17432241
41regulation of mitotic metaphase/anaphase transition (GO:0030071)3.17155054
42regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.17155054
43non-recombinational repair (GO:0000726)3.16477111
44double-strand break repair via nonhomologous end joining (GO:0006303)3.16477111
45negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.15893546
46negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.15893546
47negative regulation of mitotic sister chromatid segregation (GO:0033048)3.15893546
48negative regulation of mitotic sister chromatid separation (GO:2000816)3.15893546
49negative regulation of sister chromatid segregation (GO:0033046)3.15893546
50regulation of chromosome segregation (GO:0051983)3.15320657
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.14263818
52meiotic chromosome segregation (GO:0045132)3.13546062
53regulation of histone H3-K9 methylation (GO:0051570)3.13169293
54mitotic recombination (GO:0006312)3.13066989
55translational initiation (GO:0006413)3.12684675
56regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.10530909
57mitotic metaphase plate congression (GO:0007080)3.09653871
58mitotic G2/M transition checkpoint (GO:0044818)3.09641476
59synapsis (GO:0007129)3.08702930
60translational elongation (GO:0006414)3.07291945
61regulation of sister chromatid segregation (GO:0033045)3.03880649
62regulation of mitotic sister chromatid separation (GO:0010965)3.03880649
63regulation of mitotic sister chromatid segregation (GO:0033047)3.03880649
64mitotic spindle assembly checkpoint (GO:0007094)3.03861707
65DNA geometric change (GO:0032392)3.03445208
66DNA duplex unwinding (GO:0032508)3.03105449
67nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.02337287
68purine nucleobase biosynthetic process (GO:0009113)3.01861514
69negative regulation of mRNA processing (GO:0050686)3.01782711
70regulation of spindle organization (GO:0090224)3.01740628
71establishment of integrated proviral latency (GO:0075713)3.01460767
72DNA synthesis involved in DNA repair (GO:0000731)3.01091202
73sister chromatid cohesion (GO:0007062)2.99689330
74ribosomal small subunit biogenesis (GO:0042274)2.98310903
75positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.98193658
76positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.98193658
77positive regulation of mitotic sister chromatid separation (GO:1901970)2.98193658
78spindle assembly checkpoint (GO:0071173)2.97669182
79regulation of translational fidelity (GO:0006450)2.97653517
80DNA replication checkpoint (GO:0000076)2.96467645
81histone exchange (GO:0043486)2.96101677
82chromosome segregation (GO:0007059)2.95642952
83DNA conformation change (GO:0071103)2.93042165
84chromosome condensation (GO:0030261)2.92667233
85negative regulation of histone methylation (GO:0031061)2.91760871
86ribonucleoprotein complex biogenesis (GO:0022613)2.91090915
87regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.88621524
88tetrahydrofolate metabolic process (GO:0046653)2.86973602
89negative regulation of DNA repair (GO:0045738)2.85014969
90negative regulation of mRNA metabolic process (GO:1903312)2.83133174
91regulation of interferon-beta biosynthetic process (GO:0045357)2.83124974
92regulation of centrosome duplication (GO:0010824)2.82923160
93chromatin remodeling at centromere (GO:0031055)2.81920922
94CENP-A containing nucleosome assembly (GO:0034080)2.81745317
95regulation of DNA endoreduplication (GO:0032875)2.81121714
96telomere maintenance via telomere lengthening (GO:0010833)2.80576927
97ribosome biogenesis (GO:0042254)2.80549304
98SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.80415416
99positive regulation of SMAD protein import into nucleus (GO:0060391)2.78806333
100positive regulation of chromosome segregation (GO:0051984)2.77661018
101DNA replication-independent nucleosome assembly (GO:0006336)2.76982901
102DNA replication-independent nucleosome organization (GO:0034724)2.76982901
103metaphase plate congression (GO:0051310)2.76868348
104protein targeting to ER (GO:0045047)2.73181171
105cotranslational protein targeting to membrane (GO:0006613)2.72026077
106nucleotide-excision repair, DNA gap filling (GO:0006297)2.71582903
107mitotic sister chromatid cohesion (GO:0007064)2.70870913
108mitotic chromosome condensation (GO:0007076)2.70124261
109regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.68236494
110B cell mediated immunity (GO:0019724)2.67997228
111regulation of helicase activity (GO:0051095)2.65759949
112nuclear envelope organization (GO:0006998)2.65390269
113positive regulation by organism of defense response of other organism involved in symbiotic interact2.65062398
114modulation by symbiont of host immune response (GO:0052553)2.65062398
115positive regulation by symbiont of host defense response (GO:0052509)2.65062398
116modulation by symbiont of host defense response (GO:0052031)2.65062398
117modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.65062398
118modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.65062398
119regulation of posttranscriptional gene silencing (GO:0060147)2.64979774
120regulation of gene silencing by miRNA (GO:0060964)2.64979774
121regulation of gene silencing by RNA (GO:0060966)2.64979774
122rRNA processing (GO:0006364)2.64443829
123regulation of RNA export from nucleus (GO:0046831)2.64263779
124viral life cycle (GO:0019058)2.63060844
125establishment of chromosome localization (GO:0051303)2.61298313
126cellular protein complex disassembly (GO:0043624)2.61255952
127establishment of protein localization to endoplasmic reticulum (GO:0072599)2.60946686
128somatic diversification of immune receptors via somatic mutation (GO:0002566)2.60685048
129somatic hypermutation of immunoglobulin genes (GO:0016446)2.60685048
130regulation of translational termination (GO:0006449)2.60602789
131regulation of mitotic spindle organization (GO:0060236)2.60081893
132regulation of translation in response to stress (GO:0043555)2.59879784
133pre-miRNA processing (GO:0031054)2.56835834
134rRNA metabolic process (GO:0016072)2.56379666
135chromatin assembly or disassembly (GO:0006333)2.55208550
136immunoglobulin mediated immune response (GO:0016064)2.52302881
137protein localization to endoplasmic reticulum (GO:0070972)2.50772865
138nuclear-transcribed mRNA catabolic process (GO:0000956)2.50715555
139translesion synthesis (GO:0019985)2.50710070
140kinetochore organization (GO:0051383)2.50433223
141attachment of spindle microtubules to kinetochore (GO:0008608)2.49861521
142heterochromatin organization (GO:0070828)2.49831144
143telomere maintenance (GO:0000723)2.47369540
144telomere organization (GO:0032200)2.47024367
145negative regulation of RNA splicing (GO:0033119)2.46197211
146protein localization to chromosome (GO:0034502)2.46014805
147negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.44940912
148chromatin assembly (GO:0031497)2.44825137

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.43867928
2* FOXM1_23109430_ChIP-Seq_U2OS_Human3.80768753
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.56565903
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.31798204
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.13735085
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.01775634
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.62504293
8* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.52206454
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.33273127
10MYC_22102868_ChIP-Seq_BL_Human2.24365677
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.11488265
12NELFA_20434984_ChIP-Seq_ESCs_Mouse2.09036281
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.05893869
14GABP_17652178_ChIP-ChIP_JURKAT_Human1.98765337
15SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.96415424
16* ETS1_20019798_ChIP-Seq_JURKAT_Human1.94508832
17* VDR_23849224_ChIP-Seq_CD4+_Human1.88264446
18IRF8_21731497_ChIP-ChIP_J774_Mouse1.87563298
19* XRN2_22483619_ChIP-Seq_HELA_Human1.86739658
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.86249408
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.85818154
22E2F1_21310950_ChIP-Seq_MCF-7_Human1.83673377
23* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.79004550
24ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.77689616
25* AR_21909140_ChIP-Seq_LNCAP_Human1.76985835
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.75436204
27ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.74428398
28TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.73109730
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.71626734
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.70998800
31PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.69454541
32IRF8_22096565_ChIP-ChIP_GC-B_Human1.69187219
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.68675404
34* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.67782766
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67045143
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.67029461
37HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.63630133
38VDR_21846776_ChIP-Seq_THP-1_Human1.58073098
39* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.56733104
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.56319339
41SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.56119207
42* FOXP3_21729870_ChIP-Seq_TREG_Human1.54536812
43TFEB_21752829_ChIP-Seq_HELA_Human1.53904435
44E2F1_18555785_ChIP-Seq_MESCs_Mouse1.53325585
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.52532729
46SPI1_23547873_ChIP-Seq_NB4_Human1.52369442
47ELK1_19687146_ChIP-ChIP_HELA_Human1.50581084
48MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.49114602
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.48548368
50DCP1A_22483619_ChIP-Seq_HELA_Human1.47052235
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45742652
52CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.44808592
53* CIITA_25753668_ChIP-Seq_RAJI_Human1.43980014
54* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.43938349
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43467464
56* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42193803
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.41313263
58HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.38883581
59* TTF2_22483619_ChIP-Seq_HELA_Human1.38284367
60RBPJ_22232070_ChIP-Seq_NCS_Mouse1.37787226
61MYB_21317192_ChIP-Seq_ERMYB_Mouse1.37497039
62ESR1_15608294_ChIP-ChIP_MCF-7_Human1.36861868
63KDM5A_27292631_Chip-Seq_BREAST_Human1.36462216
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35231381
65ZNF263_19887448_ChIP-Seq_K562_Human1.34100551
66SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.33801182
67GABP_19822575_ChIP-Seq_HepG2_Human1.33235418
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31409279
69POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.30893669
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30166182
71ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29682852
72CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.28130725
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27971931
74IRF8_27001747_Chip-Seq_BMDM_Mouse1.27489722
75NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27156027
76STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23551288
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22860918
78MYB_26560356_Chip-Seq_TH2_Human1.18834998
79BRD4_27068464_Chip-Seq_AML-cells_Mouse1.18789686
80* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18352082
81SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18349403
82E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.17793671
83FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.17724428
84NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14176331
85MYB_26560356_Chip-Seq_TH1_Human1.12955511
86* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12805402
87MAF_26560356_Chip-Seq_TH1_Human1.11012388
88RUNX1_22412390_ChIP-Seq_EML_Mouse1.09287012
89NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08297873
90NOTCH1_21737748_ChIP-Seq_TLL_Human1.06712713
91SCL_19346495_ChIP-Seq_HPC-7_Human1.06485901
92* SOX17_20123909_ChIP-Seq_XEN_Mouse1.06099477
93E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04830962
94YY1_21170310_ChIP-Seq_MESCs_Mouse1.03659925
95KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.03439429
96KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.03439429
97KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.03439429
98GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03368981
99STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02266612
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01905938
101SRF_21415370_ChIP-Seq_HL-1_Mouse1.01692756
102THAP11_20581084_ChIP-Seq_MESCs_Mouse0.99491944
103UTX_26944678_Chip-Seq_JUKART_Human0.98625262
104ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96908380
105ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96770950
106HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.95482735
107VDR_24763502_ChIP-Seq_THP-1_Human0.95064694
108CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94605683
109DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94537405
110STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.92476328
111SALL4_18804426_ChIP-ChIP_XEN_Mouse0.90538647
112PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90490045
113* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90332470
114GATA6_25053715_ChIP-Seq_YYC3_Human0.88158577
115TCF3_18692474_ChIP-Seq_MEFs_Mouse0.87934063
116CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87919030
117TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87895568
118SALL1_21062744_ChIP-ChIP_HESCs_Human0.87560560
119POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.86602916
120EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.85460893
121SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.85144360
122NANOG_16153702_ChIP-ChIP_HESCs_Human0.82609384
123NANOG_21062744_ChIP-ChIP_HESCs_Human0.82265280
124TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81200569
125* HNF4A_19822575_ChIP-Seq_HepG2_Human0.80941582
126NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.79547757
127CHD1_26751641_Chip-Seq_LNCaP_Human0.79413312
128CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.79346743

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.74402133
2MP0010094_abnormal_chromosome_stability3.22662757
3MP0003111_abnormal_nucleus_morphology3.14414219
4MP0008057_abnormal_DNA_replication3.10261596
5MP0004957_abnormal_blastocyst_morpholog3.06098925
6MP0003077_abnormal_cell_cycle2.94151951
7MP0002396_abnormal_hematopoietic_system2.53433596
8MP0001835_abnormal_antigen_presentation2.51472319
9MP0010307_abnormal_tumor_latency2.46953639
10MP0010352_gastrointestinal_tract_polyps2.44481328
11MP0003941_abnormal_skin_development2.15369219
12MP0008007_abnormal_cellular_replicative2.11451069
13MP0003718_maternal_effect2.07616164
14MP0008058_abnormal_DNA_repair2.06048763
15MP0002139_abnormal_hepatobiliary_system1.95371626
16MP0003806_abnormal_nucleotide_metabolis1.90497856
17MP0001800_abnormal_humoral_immune1.89540461
18MP0005058_abnormal_lysosome_morphology1.82175661
19MP0003890_abnormal_embryonic-extraembry1.81492542
20MP0001730_embryonic_growth_arrest1.81381817
21MP0002452_abnormal_antigen_presenting1.79867655
22MP0000490_abnormal_crypts_of1.79325358
23MP0009697_abnormal_copulation1.77715718
24MP0000350_abnormal_cell_proliferation1.76176202
25MP0005360_urolithiasis1.71847952
26MP0003303_peritoneal_inflammation1.71545313
27MP0003950_abnormal_plasma_membrane1.68821901
28MP0009333_abnormal_splenocyte_physiolog1.67424090
29MP0001666_abnormal_nutrient_absorption1.67405496
30MP0005408_hypopigmentation1.67299503
31MP0002398_abnormal_bone_marrow1.67121176
32MP0004808_abnormal_hematopoietic_stem1.66323687
33MP0004264_abnormal_extraembryonic_tissu1.64571074
34MP0005000_abnormal_immune_tolerance1.63320565
35MP0003436_decreased_susceptibility_to1.63247763
36MP0000685_abnormal_immune_system1.62940020
37MP0008932_abnormal_embryonic_tissue1.60605832
38MP0000689_abnormal_spleen_morphology1.59378870
39MP0005671_abnormal_response_to1.57635554
40MP0002420_abnormal_adaptive_immunity1.55193545
41MP0002723_abnormal_immune_serum1.54974468
42MP0001819_abnormal_immune_cell1.53681500
43MP0002722_abnormal_immune_system1.52881394
44MP0005076_abnormal_cell_differentiation1.52569926
45MP0005451_abnormal_body_composition1.46472772
46MP0005387_immune_system_phenotype1.46249073
47MP0001790_abnormal_immune_system1.46249073
48MP0006082_CNS_inflammation1.44825355
49MP0000716_abnormal_immune_system1.44534796
50MP0002419_abnormal_innate_immunity1.42901183
51MP0002429_abnormal_blood_cell1.36826282
52MP0001661_extended_life_span1.34684663
53MP0002405_respiratory_system_inflammati1.32994067
54MP0001672_abnormal_embryogenesis/_devel1.32951779
55MP0005380_embryogenesis_phenotype1.32951779
56MP0002019_abnormal_tumor_incidence1.32713373
57MP0003763_abnormal_thymus_physiology1.32550088
58MP0000703_abnormal_thymus_morphology1.32460263
59MP0003123_paternal_imprinting1.31697838
60MP0005025_abnormal_response_to1.30176193
61MP0001697_abnormal_embryo_size1.29126959
62MP0009840_abnormal_foam_cell1.26636324
63MP0005397_hematopoietic_system_phenotyp1.26604283
64MP0001545_abnormal_hematopoietic_system1.26604283
65MP0002086_abnormal_extraembryonic_tissu1.24894561
66MP0000313_abnormal_cell_death1.24382331
67MP0003705_abnormal_hypodermis_morpholog1.24219292
68MP0003943_abnormal_hepatobiliary_system1.24198586
69MP0003984_embryonic_growth_retardation1.24015348
70MP0003566_abnormal_cell_adhesion1.24001951
71MP0009278_abnormal_bone_marrow1.22924703
72MP0000465_gastrointestinal_hemorrhage1.22752728
73MP0002080_prenatal_lethality1.22578113
74MP0002088_abnormal_embryonic_growth/wei1.22027834
75MP0003172_abnormal_lysosome_physiology1.21585362
76MP0000858_altered_metastatic_potential1.21012662
77MP0000566_synostosis1.20606002
78MP0001853_heart_inflammation1.20404708
79MP0003300_gastrointestinal_ulcer1.20375234
80MP0005464_abnormal_platelet_physiology1.20163493
81MP0002148_abnormal_hypersensitivity_rea1.19489406
82MP0003448_altered_tumor_morphology1.17877737
83MP0004197_abnormal_fetal_growth/weight/1.16976125
84MP0006292_abnormal_olfactory_placode1.14755382
85MP0003191_abnormal_cellular_cholesterol1.12973041
86MP0005365_abnormal_bile_salt1.10971291
87MP0003786_premature_aging1.10864179
88MP0001929_abnormal_gametogenesis1.10788307
89MP0003567_abnormal_fetal_cardiomyocyte1.09963143
90MP0002210_abnormal_sex_determination1.09387414
91MP0010155_abnormal_intestine_physiology1.07041650
92MP0002085_abnormal_embryonic_tissue1.05143279
93MP0002084_abnormal_developmental_patter1.04910941
94MP0009785_altered_susceptibility_to1.04836636
95MP0003315_abnormal_perineum_morphology1.04752078
96MP0006054_spinal_hemorrhage1.03468361
97MP0002166_altered_tumor_susceptibility1.01732297
98MP0001915_intracranial_hemorrhage1.00811775
99MP0002938_white_spotting1.00196363
100MP0002009_preneoplasia0.98028366
101MP0002089_abnormal_postnatal_growth/wei0.96171134
102MP0000609_abnormal_liver_physiology0.95688973
103MP0006035_abnormal_mitochondrial_morpho0.94753631
104MP0005023_abnormal_wound_healing0.94399227
105MP0001845_abnormal_inflammatory_respons0.94360218
106MP0001145_abnormal_male_reproductive0.94232216
107MP0001293_anophthalmia0.94104667
108MP0003868_abnormal_feces_composition0.93799670
109MP0010329_abnormal_lipoprotein_level0.93547279
110MP0002697_abnormal_eye_size0.92121615
111MP0003937_abnormal_limbs/digits/tail_de0.91844007
112MP0004947_skin_inflammation0.89722661
113MP0000358_abnormal_cell_content/0.89557758
114MP0003699_abnormal_female_reproductive0.87814007
115MP0001873_stomach_inflammation0.87610154
116MP0000598_abnormal_liver_morphology0.87291058
117MP0002006_tumorigenesis0.86526227
118MP0000653_abnormal_sex_gland0.85879844
119MP0004233_abnormal_muscle_weight0.85688275
120MP0001286_abnormal_eye_development0.85398526
121MP0005310_abnormal_salivary_gland0.81885778
122MP0000733_abnormal_muscle_development0.81710553
123MP0002160_abnormal_reproductive_system0.80384433
124MP0003122_maternal_imprinting0.80251010
125MP0005621_abnormal_cell_physiology0.79392413
126MP0008877_abnormal_DNA_methylation0.78889652
127MP0000477_abnormal_intestine_morphology0.78611565
128MP0005085_abnormal_gallbladder_physiolo0.78296196
129MP0001764_abnormal_homeostasis0.77625803
130MP0000371_diluted_coat_color0.75016879
131MP0003195_calcinosis0.74586343
132MP0005332_abnormal_amino_acid0.74271682
133MP0009703_decreased_birth_body0.74069969
134MP0001119_abnormal_female_reproductive0.73740160
135MP0005384_cellular_phenotype0.73572938
136MP0001533_abnormal_skeleton_physiology0.72964862
137MP0002092_abnormal_eye_morphology0.72422520
138MP0008260_abnormal_autophagy0.72360532
139MP0003221_abnormal_cardiomyocyte_apopto0.71540521
140MP0003186_abnormal_redox_activity0.71301521
141MP0005174_abnormal_tail_pigmentation0.70246234
142MP0003828_pulmonary_edema0.69485288
143MP0004782_abnormal_surfactant_physiolog0.65679920
144MP0005395_other_phenotype0.65182581
145MP0009672_abnormal_birth_weight0.65085309
146MP0005220_abnormal_exocrine_pancreas0.64762470
147MP0000627_abnormal_mammary_gland0.63925926
148MP0006036_abnormal_mitochondrial_physio0.63858510
149MP0008469_abnormal_protein_level0.62312253
150MP0002161_abnormal_fertility/fecundity0.62047325
151MP0003698_abnormal_male_reproductive0.61935924
152MP0002877_abnormal_melanocyte_morpholog0.61848945
153MP0004185_abnormal_adipocyte_glucose0.60413012
154MP0010234_abnormal_vibrissa_follicle0.59762704

Predicted human phenotypes

RankGene SetZ-score
1Agnosia (HP:0010524)4.60511304
2Hypobetalipoproteinemia (HP:0003563)4.57181310
3Nephroblastoma (Wilms tumor) (HP:0002667)4.22583329
4Deep venous thrombosis (HP:0002625)4.22167354
5Embryonal renal neoplasm (HP:0011794)3.97145423
6Prolonged partial thromboplastin time (HP:0003645)3.70294400
7Reticulocytopenia (HP:0001896)3.65811143
8Birth length less than 3rd percentile (HP:0003561)3.52478347
9Abnormality of the ileum (HP:0001549)3.46307213
10Recurrent abscess formation (HP:0002722)3.43346494
11Small epiphyses (HP:0010585)3.37948000
12Multiple enchondromatosis (HP:0005701)3.22067328
13Acanthocytosis (HP:0001927)3.08535702
14Microvesicular hepatic steatosis (HP:0001414)3.04254743
15Abnormality of cells of the erythroid lineage (HP:0012130)2.95160683
16IgM deficiency (HP:0002850)2.90408769
17Colon cancer (HP:0003003)2.84922622
18Abnormality of the common coagulation pathway (HP:0010990)2.82741500
19Recurrent bacterial skin infections (HP:0005406)2.81480339
20Abnormality of glycolysis (HP:0004366)2.78348107
21Cellulitis (HP:0100658)2.76998592
22Aplasia/Hypoplasia of the uvula (HP:0010293)2.76372239
23Increased serum pyruvate (HP:0003542)2.75147855
24Increased cerebral lipofuscin (HP:0011813)2.75041306
25Pancreatic islet-cell hyperplasia (HP:0004510)2.74632631
26Vaginal fistula (HP:0004320)2.74377728
27Abnormal lung lobation (HP:0002101)2.73689332
28Disinhibition (HP:0000734)2.73194064
29Hypolipoproteinemia (HP:0010981)2.71235649
30Embryonal neoplasm (HP:0002898)2.70527843
31Recurrent viral infections (HP:0004429)2.68192450
32Abnormal number of erythroid precursors (HP:0012131)2.67458817
33Ependymoma (HP:0002888)2.66945023
34Eczematoid dermatitis (HP:0000976)2.64117127
35Hyperglycinuria (HP:0003108)2.63685543
36Increased nuchal translucency (HP:0010880)2.63531589
37Rectal fistula (HP:0100590)2.61215580
38Rectovaginal fistula (HP:0000143)2.61215580
39Abnormal tarsal ossification (HP:0008369)2.57889012
40Small intestinal stenosis (HP:0012848)2.55219663
41Duodenal stenosis (HP:0100867)2.55219663
42Chromsome breakage (HP:0040012)2.50283250
43Irregular epiphyses (HP:0010582)2.49926289
44Progressive external ophthalmoplegia (HP:0000590)2.48797916
45Thrombocytosis (HP:0001894)2.47547778
46Selective tooth agenesis (HP:0001592)2.45782325
47Hematochezia (HP:0002573)2.45077732
48Abnormality of methionine metabolism (HP:0010901)2.41805471
49Increased neuronal autofluorescent lipopigment (HP:0002074)2.41495335
50Lymphoma (HP:0002665)2.40045785
51Abnormality of the anterior horn cell (HP:0006802)2.39821539
52Degeneration of anterior horn cells (HP:0002398)2.39821539
53Medulloblastoma (HP:0002885)2.39708698
54Abnormality of chromosome stability (HP:0003220)2.35517627
55Vacuolated lymphocytes (HP:0001922)2.33647689
56Absent radius (HP:0003974)2.33550170
57Basal cell carcinoma (HP:0002671)2.31786127
58Breast hypoplasia (HP:0003187)2.30719118
59Capillary hemangiomas (HP:0005306)2.29050486
60Abnormality of macrophages (HP:0004311)2.28485478
61Intestinal fistula (HP:0100819)2.27871784
62Abnormality of glycine metabolism (HP:0010895)2.27796726
63Abnormality of serine family amino acid metabolism (HP:0010894)2.27796726
64Amaurosis fugax (HP:0100576)2.26756375
65Proximal tubulopathy (HP:0000114)2.26413895
66Abnormal foot bone ossification (HP:0010675)2.25933844
67Recurrent fungal infections (HP:0002841)2.22700038
68Personality changes (HP:0000751)2.21477189
69Chromosomal breakage induced by crosslinking agents (HP:0003221)2.21408155
70Osteolytic defects of the phalanges of the hand (HP:0009771)2.21247861
71Osteolytic defects of the hand bones (HP:0009699)2.21247861
72Carpal bone hypoplasia (HP:0001498)2.20621637
73Macrocytic anemia (HP:0001972)2.19546497
74Pustule (HP:0200039)2.18192956
75Myelodysplasia (HP:0002863)2.18167069
76Pallor (HP:0000980)2.17262466
77Overlapping toe (HP:0001845)2.16493640
78Poikiloderma (HP:0001029)2.14752618
79Reduced antithrombin III activity (HP:0001976)2.14179666
80Rough bone trabeculation (HP:0100670)2.14017926
81Neoplasm of the colon (HP:0100273)2.13789329
82Papillary thyroid carcinoma (HP:0002895)2.13714956
83Asymmetry of the thorax (HP:0001555)2.12082641
84Anal stenosis (HP:0002025)2.09179091
85Hypercholesterolemia (HP:0003124)2.08519482
86Biliary tract neoplasm (HP:0100574)2.07711119
87Absent forearm bone (HP:0003953)2.07601346
88Aplasia involving forearm bones (HP:0009822)2.07601346
89T lymphocytopenia (HP:0005403)2.06732629
90Abnormality of the duodenum (HP:0002246)2.05661341
91Osteomyelitis (HP:0002754)2.05617235
92Hypoglycemic coma (HP:0001325)2.05054869
93Spontaneous abortion (HP:0005268)2.04537894
94Abnormality of carpal bone ossification (HP:0006257)2.04429504
95Leukopenia (HP:0001882)2.03850228
96Oral leukoplakia (HP:0002745)2.03218170
97Neoplasm of the pancreas (HP:0002894)2.01791086
98Diastasis recti (HP:0001540)2.01782837
99Gastrointestinal inflammation (HP:0004386)2.01710410
100Premature ovarian failure (HP:0008209)2.01583286
101Hypoplasia of the capital femoral epiphysis (HP:0003090)2.01417489
102Abnormality of T cells (HP:0002843)2.00089857
103Prominent nose (HP:0000448)1.99198439
104Absent thumb (HP:0009777)1.98529876
105Rhabdomyosarcoma (HP:0002859)1.97773410
106Abnormality of cochlea (HP:0000375)1.97364224
107Abnormality of DNA repair (HP:0003254)1.96534221
108Supernumerary spleens (HP:0009799)1.96003467
109Inflammation of the large intestine (HP:0002037)1.95776858
110Sloping forehead (HP:0000340)1.95451461
111Proximal placement of thumb (HP:0009623)1.95372707
112Cafe-au-lait spot (HP:0000957)1.95228082
113Hepatoblastoma (HP:0002884)1.95225964
114Spinal muscular atrophy (HP:0007269)1.94714678
115Abnormality of the intrinsic pathway (HP:0010989)1.93454769
116Type I transferrin isoform profile (HP:0003642)1.93033103
117Broad alveolar ridges (HP:0000187)1.92930206
118Systemic lupus erythematosus (HP:0002725)1.92894206
119Neoplasm of the oral cavity (HP:0100649)1.92766567
120Bone marrow hypocellularity (HP:0005528)1.91932609
121Hyperglycinemia (HP:0002154)1.91837867
122Chronic obstructive pulmonary disease (HP:0006510)1.91683255
123Obstructive lung disease (HP:0006536)1.91683255
124Gastrointestinal carcinoma (HP:0002672)1.91455811
125Malignant gastrointestinal tract tumors (HP:0006749)1.91455811
126Deviation of the thumb (HP:0009603)1.90413245
127Abnormality of T cell number (HP:0011839)1.89773628
128Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.89386312
129Clubbing of toes (HP:0100760)1.89192265
130Joint hemorrhage (HP:0005261)1.89103672
131Abnormality of cells of the lymphoid lineage (HP:0012140)1.88290062
132Abnormality of the carotid arteries (HP:0005344)1.88062786
133Abnormality of T cell physiology (HP:0011840)1.87945822
134Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.87820973
135Abnormality of liposaccharide metabolism (HP:0010968)1.87243101
136Abnormality of glycosphingolipid metabolism (HP:0004343)1.87243101
137Abnormality of glycolipid metabolism (HP:0010969)1.87243101
138Premature graying of hair (HP:0002216)1.87169989
139Lymphopenia (HP:0001888)1.86699962
140Clitoromegaly (HP:0000057)1.86060227
141Triphalangeal thumb (HP:0001199)1.85390775
142Septate vagina (HP:0001153)1.85356171
143Abnormality of endocrine pancreas physiology (HP:0012093)1.85017695
144Abnormality of the pancreatic islet cells (HP:0006476)1.85017695
145Mediastinal lymphadenopathy (HP:0100721)1.84763974
146Abnormality of the vasculature of the conjunctiva (HP:0008054)1.83851773
147Colitis (HP:0002583)1.81732420
148Chronic otitis media (HP:0000389)1.81348813
149Microglossia (HP:0000171)1.80777239
150Trismus (HP:0000211)1.80452997
151Recurrent bronchitis (HP:0002837)1.79636450
152IgA deficiency (HP:0002720)1.79389608
153Blepharitis (HP:0000498)1.79299434
154Abnormal trabecular bone morphology (HP:0100671)1.78828551
155Agammaglobulinemia (HP:0004432)1.78558544
156Patellar aplasia (HP:0006443)1.78036852
157Squamous cell carcinoma (HP:0002860)1.77968705
158Cutaneous melanoma (HP:0012056)1.77846230
159Meckel diverticulum (HP:0002245)1.77744098
160Flat acetabular roof (HP:0003180)1.76112144
161Petechiae (HP:0000967)1.75379852
162Panhypogammaglobulinemia (HP:0003139)1.74954622
163Spontaneous hematomas (HP:0007420)1.74815090
164Recurrent skin infections (HP:0001581)1.74590995
165Choanal atresia (HP:0000453)1.74380880
166Megaloblastic anemia (HP:0001889)1.74241526
167Abnormality of the preputium (HP:0100587)1.73582828
168Ovarian neoplasm (HP:0100615)1.73036548
169Abnormality of the nasal septum (HP:0000419)1.72609477
170Abnormal cartilage morphology (HP:0002763)1.71984632
171Horseshoe kidney (HP:0000085)1.71567479
172Impulsivity (HP:0100710)1.71402022
173Uterine neoplasm (HP:0010784)1.71256142
174Recurrent pneumonia (HP:0006532)1.70710523
175Facial hemangioma (HP:0000329)1.70395885
176Hypophosphatemic rickets (HP:0004912)1.69658648
177Entropion (HP:0000621)1.68625429
178Conjunctival telangiectasia (HP:0000524)1.68525428
179High pitched voice (HP:0001620)1.67027111
180Basal ganglia calcification (HP:0002135)1.65262225
181Aplasia/Hypoplasia of the patella (HP:0006498)1.65190694
182Ascites (HP:0001541)1.64717629
183Tracheoesophageal fistula (HP:0002575)1.64691336
184Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.64495219
185Ectopic kidney (HP:0000086)1.64280922

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK3.03887722
2WEE12.98429697
3CDC72.81718791
4BUB12.76769650
5NEK22.52111858
6MAP4K12.35465895
7SCYL22.25106489
8CDK122.24466972
9STK102.17042059
10EIF2AK12.11429427
11NME22.06975211
12EEF2K2.06199891
13TSSK62.01370027
14FGFR41.94370647
15LATS11.86590467
16BLK1.83554990
17TTK1.80486524
18RPS6KA41.77820042
19EIF2AK31.77305781
20MAP3K101.77000769
21PASK1.73978770
22PKN21.73603466
23SMG11.71351364
24TESK21.67941787
25EPHA21.64880352
26MKNK11.63451652
27ACVR1B1.57336021
28RPS6KB21.57216607
29BRSK11.51180016
30SRPK11.51179308
31MAP3K81.48270748
32TGFBR21.47564924
33CDK41.40686522
34ATR1.39219229
35CSF1R1.38868141
36LRRK21.38780696
37PAK41.37132705
38STK41.34541506
39TAF11.33751330
40TLK11.32631997
41FGFR31.29493365
42FLT31.28943189
43CDK71.27472021
44BRSK21.26218629
45PIM11.25883012
46TYK21.25423893
47MKNK21.25249805
48PLK11.22750304
49AURKB1.22623707
50DYRK31.22287408
51CDK61.21621353
52PDK21.20693606
53WNK41.18064669
54BTK1.17956071
55BRD41.17058517
56VRK21.14680425
57ALK1.14234294
58FGFR11.13929877
59TGFBR11.12215613
60NEK11.08102198
61KIT1.04564914
62VRK11.03259728
63NEK91.02294844
64STK390.98896563
65ZAP700.96962629
66CHEK10.94339846
67MAP2K30.94221986
68CHEK20.94094734
69PLK30.92043081
70ERBB40.91558382
71STK30.91428030
72CLK10.89908063
73CDK190.88123051
74IRAK40.87945881
75PLK40.87096306
76JAK30.86634018
77GRK60.86003687
78IKBKB0.83168764
79TEC0.80120455
80MST40.79472468
81STK38L0.78738044
82ZAK0.77852085
83STK240.75497656
84NUAK10.75103335
85ATM0.74211459
86ITK0.73947394
87MAP3K130.73737058
88MAPK110.72664581
89LYN0.72551008
90TRIM280.72152216
91MST1R0.69702133
92CDK80.69607229
93CDK20.67553854
94IRAK30.67333710
95RPS6KB10.66163475
96PAK20.64128120
97MELK0.63808940
98HCK0.63668688
99LCK0.63522964
100RPS6KA50.63337329
101ICK0.61951814
102NME10.61343126
103PIK3CA0.60269260
104MARK30.59991338
105PNCK0.58705206
106SYK0.57429602
107AURKA0.56853748
108TRIB30.56398910
109TBK10.56255468
110PDGFRA0.56155803
111MET0.56087138
112FGFR20.55280836
113CSK0.55006079
114TYRO30.54279526
115PIM20.53989793
116CSNK2A20.53082597
117MTOR0.53071487
118KDR0.52966976
119AKT30.52129455
120CAMK1G0.50465931
121CSNK1E0.49782485
122PAK10.49647927
123MAP3K140.48952528
124TTN0.48407411
125STK160.47687455
126CHUK0.43846495
127WNK10.43528337
128PTK60.43266320
129MAP3K30.43020609
130CSNK2A10.42634619
131EIF2AK20.42261183
132PRKDC0.40487010
133TXK0.40273104
134CDK10.39407410
135LATS20.38378440
136MAPKAPK20.38309995
137CAMK1D0.38022905
138NEK60.37892907
139CDK90.37838518
140AKT20.36363019
141NLK0.36321723
142BRAF0.34571287
143BMPR1B0.33784036
144OXSR10.30488039
145FGR0.29014054
146PRKAA20.27885774

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.96268808
2Mismatch repair_Homo sapiens_hsa034303.47032647
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.06405904
4Spliceosome_Homo sapiens_hsa030402.75053147
5Ribosome_Homo sapiens_hsa030102.71555471
6RNA transport_Homo sapiens_hsa030132.68680925
7One carbon pool by folate_Homo sapiens_hsa006702.42111908
8Base excision repair_Homo sapiens_hsa034102.35823678
9Homologous recombination_Homo sapiens_hsa034402.21722259
10Cell cycle_Homo sapiens_hsa041102.19728169
11Nucleotide excision repair_Homo sapiens_hsa034202.18294453
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.11022832
13RNA polymerase_Homo sapiens_hsa030202.10354337
14Antigen processing and presentation_Homo sapiens_hsa046122.02505051
15Non-homologous end-joining_Homo sapiens_hsa034501.99727834
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.91062315
17Proteasome_Homo sapiens_hsa030501.72199593
18Fanconi anemia pathway_Homo sapiens_hsa034601.62425585
19Pyrimidine metabolism_Homo sapiens_hsa002401.60856669
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.58913724
21Systemic lupus erythematosus_Homo sapiens_hsa053221.55762304
22Propanoate metabolism_Homo sapiens_hsa006401.50478672
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.44471589
24p53 signaling pathway_Homo sapiens_hsa041151.44455230
25B cell receptor signaling pathway_Homo sapiens_hsa046621.44375558
26Primary immunodeficiency_Homo sapiens_hsa053401.43976720
27Biosynthesis of amino acids_Homo sapiens_hsa012301.42882079
28Steroid biosynthesis_Homo sapiens_hsa001001.41234223
29mRNA surveillance pathway_Homo sapiens_hsa030151.39039599
30Herpes simplex infection_Homo sapiens_hsa051681.38644851
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.36570102
32RNA degradation_Homo sapiens_hsa030181.34251768
33Vitamin digestion and absorption_Homo sapiens_hsa049771.32068133
34Viral carcinogenesis_Homo sapiens_hsa052031.31695059
35Epstein-Barr virus infection_Homo sapiens_hsa051691.30314511
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.29244397
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.28810412
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.28037835
39Legionellosis_Homo sapiens_hsa051341.25668349
40Fatty acid metabolism_Homo sapiens_hsa012121.25297078
41Other glycan degradation_Homo sapiens_hsa005111.24861446
42Complement and coagulation cascades_Homo sapiens_hsa046101.24235828
43Basal transcription factors_Homo sapiens_hsa030221.23913462
44Fat digestion and absorption_Homo sapiens_hsa049751.23905108
45Carbon metabolism_Homo sapiens_hsa012001.23548598
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22664681
47Leishmaniasis_Homo sapiens_hsa051401.21806931
48Pyruvate metabolism_Homo sapiens_hsa006201.18388502
49Fatty acid degradation_Homo sapiens_hsa000711.18331054
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15712556
51Measles_Homo sapiens_hsa051621.13353837
52Lysine degradation_Homo sapiens_hsa003101.11600033
53Lysosome_Homo sapiens_hsa041421.09087255
54Osteoclast differentiation_Homo sapiens_hsa043801.05398761
55Glycosaminoglycan degradation_Homo sapiens_hsa005311.05323124
56Apoptosis_Homo sapiens_hsa042101.05105127
57Fatty acid biosynthesis_Homo sapiens_hsa000611.03306542
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00269520
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99606786
60Hematopoietic cell lineage_Homo sapiens_hsa046400.98603730
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95919382
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.93468728
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.91264195
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91011271
65HTLV-I infection_Homo sapiens_hsa051660.90239335
66Staphylococcus aureus infection_Homo sapiens_hsa051500.89269399
67Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89058858
68Small cell lung cancer_Homo sapiens_hsa052220.87965096
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.87834678
70Chronic myeloid leukemia_Homo sapiens_hsa052200.87682567
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86525948
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.86319207
73Shigellosis_Homo sapiens_hsa051310.85396817
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83239350
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.81872239
76Hepatitis B_Homo sapiens_hsa051610.80587751
77MicroRNAs in cancer_Homo sapiens_hsa052060.80586704
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80130940
79Toll-like receptor signaling pathway_Homo sapiens_hsa046200.79592688
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79042466
81Glutathione metabolism_Homo sapiens_hsa004800.78568942
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77957359
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77650020
84Fatty acid elongation_Homo sapiens_hsa000620.76331400
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.75140231
86Tuberculosis_Homo sapiens_hsa051520.75023783
87Protein export_Homo sapiens_hsa030600.74881135
88Pentose phosphate pathway_Homo sapiens_hsa000300.74813071
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73870910
90Influenza A_Homo sapiens_hsa051640.73090114
91Toxoplasmosis_Homo sapiens_hsa051450.69564110
92Fructose and mannose metabolism_Homo sapiens_hsa000510.68077698
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67313090
94Arginine and proline metabolism_Homo sapiens_hsa003300.66230022
95Pertussis_Homo sapiens_hsa051330.64921544
96Purine metabolism_Homo sapiens_hsa002300.64576056
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63089934
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62620310
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62347348
100Arginine biosynthesis_Homo sapiens_hsa002200.60837820
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59984865
102T cell receptor signaling pathway_Homo sapiens_hsa046600.59747255
103Colorectal cancer_Homo sapiens_hsa052100.59734112
104Selenocompound metabolism_Homo sapiens_hsa004500.58905188
105Viral myocarditis_Homo sapiens_hsa054160.58863774
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.58822401
107Acute myeloid leukemia_Homo sapiens_hsa052210.58699453
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57456045
109PPAR signaling pathway_Homo sapiens_hsa033200.55933367
110Malaria_Homo sapiens_hsa051440.55213245
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54727345
112Pancreatic cancer_Homo sapiens_hsa052120.52850033
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.49950002
114Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48887252
115Renin-angiotensin system_Homo sapiens_hsa046140.47371530
116Thyroid cancer_Homo sapiens_hsa052160.47148337
117mTOR signaling pathway_Homo sapiens_hsa041500.46723561
118Notch signaling pathway_Homo sapiens_hsa043300.46650822
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45822100
120Folate biosynthesis_Homo sapiens_hsa007900.45161215
121Asthma_Homo sapiens_hsa053100.43333712
122Allograft rejection_Homo sapiens_hsa053300.42926644
123Starch and sucrose metabolism_Homo sapiens_hsa005000.42077447
124HIF-1 signaling pathway_Homo sapiens_hsa040660.41575914
125Non-small cell lung cancer_Homo sapiens_hsa052230.41199748
126N-Glycan biosynthesis_Homo sapiens_hsa005100.41153896
127Galactose metabolism_Homo sapiens_hsa000520.40776709
128Bladder cancer_Homo sapiens_hsa052190.40535519
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40135504
130Prostate cancer_Homo sapiens_hsa052150.40109478
131Metabolic pathways_Homo sapiens_hsa011000.39708507
132TGF-beta signaling pathway_Homo sapiens_hsa043500.38701002
133Adherens junction_Homo sapiens_hsa045200.38106216
134Vitamin B6 metabolism_Homo sapiens_hsa007500.37946639
135Salmonella infection_Homo sapiens_hsa051320.37592056
136Peroxisome_Homo sapiens_hsa041460.37500703
137Proteoglycans in cancer_Homo sapiens_hsa052050.35837689
138Drug metabolism - other enzymes_Homo sapiens_hsa009830.34557163
139Chemokine signaling pathway_Homo sapiens_hsa040620.34339866
140Graft-versus-host disease_Homo sapiens_hsa053320.34125938
141Sulfur relay system_Homo sapiens_hsa041220.33811555
142Oocyte meiosis_Homo sapiens_hsa041140.33742876
143Histidine metabolism_Homo sapiens_hsa003400.18309132
144Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.18110567
145Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.16848586
146Tyrosine metabolism_Homo sapiens_hsa003500.14911787
147beta-Alanine metabolism_Homo sapiens_hsa004100.14505349
148Nitrogen metabolism_Homo sapiens_hsa009100.14223675
149Sulfur metabolism_Homo sapiens_hsa009200.13812785

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