SNX5P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.27150755
2negative regulation of heart rate (GO:0010459)5.29474561
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.04177891
4proteasome assembly (GO:0043248)4.86084374
5cytidine deamination (GO:0009972)4.83647589
6cytidine metabolic process (GO:0046087)4.83647589
7cytidine catabolic process (GO:0006216)4.83647589
8pyrimidine ribonucleoside catabolic process (GO:0046133)4.57333785
9Arp2/3 complex-mediated actin nucleation (GO:0034314)4.50158476
10ATP synthesis coupled proton transport (GO:0015986)4.37361208
11energy coupled proton transport, down electrochemical gradient (GO:0015985)4.37361208
12mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.34468882
13positive regulation of fibroblast migration (GO:0010763)4.21026428
14actin nucleation (GO:0045010)4.03933976
15RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.75359675
16cullin deneddylation (GO:0010388)3.70886746
17termination of RNA polymerase III transcription (GO:0006386)3.67085433
18transcription elongation from RNA polymerase III promoter (GO:0006385)3.67085433
19regulation of RIG-I signaling pathway (GO:0039535)3.48216156
20histone mRNA metabolic process (GO:0008334)3.47530477
21positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.42770078
22protein prenylation (GO:0018342)3.41162547
23prenylation (GO:0097354)3.41162547
24regulation of T cell tolerance induction (GO:0002664)3.40476917
25protein deneddylation (GO:0000338)3.39705737
26negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.38179202
27GMP metabolic process (GO:0046037)3.36693982
28positive regulation of natural killer cell mediated immunity (GO:0002717)3.35040215
29antigen processing and presentation via MHC class Ib (GO:0002475)3.34577351
30positive regulation of interleukin-8 secretion (GO:2000484)3.32197925
31establishment of protein localization to mitochondrial membrane (GO:0090151)3.30958364
32regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.27089490
33regulation of cellular amino acid metabolic process (GO:0006521)3.25940976
34regulation of interleukin-8 secretion (GO:2000482)3.25643836
35positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.23543984
36DNA damage response, detection of DNA damage (GO:0042769)3.22961473
37protein neddylation (GO:0045116)3.19539486
38respiratory chain complex IV assembly (GO:0008535)3.15822127
39purine-containing compound salvage (GO:0043101)3.13502184
40exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.13093923
41positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.08901059
42respiratory electron transport chain (GO:0022904)3.08333440
43nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.07685203
44negative regulation of ligase activity (GO:0051352)3.06604476
45negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.06604476
46positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.06097673
47CENP-A containing nucleosome assembly (GO:0034080)3.03982964
48electron transport chain (GO:0022900)3.02990663
49rRNA catabolic process (GO:0016075)3.01620706
50regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.01515247
51mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.01139065
52chromatin remodeling at centromere (GO:0031055)3.00794214
53endoderm formation (GO:0001706)3.00440244
54platelet dense granule organization (GO:0060155)3.00112256
55mitochondrial calcium ion transport (GO:0006851)3.00106726
56signal peptide processing (GO:0006465)2.97773400
57mast cell activation (GO:0045576)2.97518250
58cytolysis (GO:0019835)2.96511655
59positive regulation of cell killing (GO:0031343)2.95165595
60negative T cell selection (GO:0043383)2.94371918
61S-adenosylmethionine metabolic process (GO:0046500)2.93982476
62positive regulation of T-helper 1 type immune response (GO:0002827)2.93607782
63antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.92891851
64negative thymic T cell selection (GO:0045060)2.91270160
65regulation of leukocyte mediated cytotoxicity (GO:0001910)2.91196083
66regulation of glomerular filtration (GO:0003093)2.90100998
67protein localization to kinetochore (GO:0034501)2.88565470
68response to testosterone (GO:0033574)2.86772541
69regulation of interleukin-2 biosynthetic process (GO:0045076)2.86280833
70antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.85693588
71regulation of mitotic spindle checkpoint (GO:1903504)2.85228711
72regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.85228711
73antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.84240066
74positive regulation of alpha-beta T cell proliferation (GO:0046641)2.81709517
75anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.81699671
76lymphocyte costimulation (GO:0031294)2.78700047
77purine nucleotide salvage (GO:0032261)2.78150064
78B cell mediated immunity (GO:0019724)2.76951027
79DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.76120758
80positive regulation of T cell mediated cytotoxicity (GO:0001916)2.75630698
81regulation of chronic inflammatory response (GO:0002676)2.74596739
82regulation of B cell receptor signaling pathway (GO:0050855)2.74352603
83regulation of tolerance induction (GO:0002643)2.73504624
84T cell costimulation (GO:0031295)2.71474793
85regulation of natural killer cell mediated immunity (GO:0002715)2.70542821
86regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.70542821
87purine nucleobase biosynthetic process (GO:0009113)2.69724455
88signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.68973707
89signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.68973707
90signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.68973707
91intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.67470067
92signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.67470067
93regulation of cell killing (GO:0031341)2.65411834
94AMP metabolic process (GO:0046033)2.64196451
95negative regulation of acute inflammatory response (GO:0002674)2.62886423
96regulation of isotype switching to IgG isotypes (GO:0048302)2.62036604
97protein localization to chromosome, centromeric region (GO:0071459)2.60990630
98signal transduction involved in DNA damage checkpoint (GO:0072422)2.60438257
99signal transduction involved in DNA integrity checkpoint (GO:0072401)2.60438257
100RNA phosphodiester bond hydrolysis (GO:0090501)2.57055655

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.14519923
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.91021314
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.88795119
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.76501348
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.12661734
6FLI1_27457419_Chip-Seq_LIVER_Mouse3.04901886
7VDR_23849224_ChIP-Seq_CD4+_Human2.88708671
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.67362693
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.65012963
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.58041936
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.50773590
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.48064301
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.47789819
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.45713754
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.45226564
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.38937207
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.24199933
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.23933967
19FOXP3_21729870_ChIP-Seq_TREG_Human2.18082389
20ELK1_19687146_ChIP-ChIP_HELA_Human2.17435658
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.16006067
22PCGF2_27294783_Chip-Seq_NPCs_Mouse2.11195103
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.07315762
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.99892339
25ZNF274_21170338_ChIP-Seq_K562_Hela1.95777545
26STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.94311125
27VDR_22108803_ChIP-Seq_LS180_Human1.93001371
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.88973425
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.86363976
30MYB_26560356_Chip-Seq_TH2_Human1.75853172
31CREB1_15753290_ChIP-ChIP_HEK293T_Human1.72873992
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.70146031
33GATA3_26560356_Chip-Seq_TH2_Human1.69455819
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.68295894
35PADI4_21655091_ChIP-ChIP_MCF-7_Human1.62264241
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.61549687
37IRF8_22096565_ChIP-ChIP_GC-B_Human1.57002746
38EWS_26573619_Chip-Seq_HEK293_Human1.56350938
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55626013
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50636588
41CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.50448847
42MYC_18555785_ChIP-Seq_MESCs_Mouse1.48594714
43SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.46727953
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.42112464
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40886332
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.38664948
47IRF1_19129219_ChIP-ChIP_H3396_Human1.38203426
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.35924713
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34966874
50EZH2_27294783_Chip-Seq_NPCs_Mouse1.33580725
51HTT_18923047_ChIP-ChIP_STHdh_Human1.33263768
52EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.31824634
53SPI1_23547873_ChIP-Seq_NB4_Human1.29130884
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.28857362
55FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.27543356
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.25011916
57BP1_19119308_ChIP-ChIP_Hs578T_Human1.22562259
58EGR1_23403033_ChIP-Seq_LIVER_Mouse1.20655135
59DCP1A_22483619_ChIP-Seq_HELA_Human1.20563006
60MYC_18940864_ChIP-ChIP_HL60_Human1.20079809
61MYC_19030024_ChIP-ChIP_MESCs_Mouse1.19035810
62MYB_26560356_Chip-Seq_TH1_Human1.17571752
63TAF15_26573619_Chip-Seq_HEK293_Human1.16053258
64E2F7_22180533_ChIP-Seq_HELA_Human1.16048986
65TP53_22573176_ChIP-Seq_HFKS_Human1.14777443
66P300_19829295_ChIP-Seq_ESCs_Human1.14735795
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14304503
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13360594
69GATA3_27048872_Chip-Seq_THYMUS_Human1.12776215
70ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12352724
71FOXA1_25329375_ChIP-Seq_VCAP_Human1.10987958
72FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10987958
73STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.10655797
74STAT4_19710469_ChIP-ChIP_TH1__Mouse1.06986198
75SOX2_19829295_ChIP-Seq_ESCs_Human1.05696257
76NANOG_19829295_ChIP-Seq_ESCs_Human1.05696257
77CRX_20693478_ChIP-Seq_RETINA_Mouse1.04499231
78RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04289987
79TTF2_22483619_ChIP-Seq_HELA_Human1.03390099
80AR_20517297_ChIP-Seq_VCAP_Human1.02882532
81RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.01951783
82MYC_18358816_ChIP-ChIP_MESCs_Mouse1.01283862
83SALL4_22934838_ChIP-ChIP_CD34+_Human0.99687670
84PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.99674737
85ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98195789
86CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96213852
87CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95996521
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95357807
89FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94930533
90GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.94674863
91HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94157504
92STAT3_18555785_Chip-Seq_ESCs_Mouse0.93755572
93RBPJ_21746931_ChIP-Seq_IB4_Human0.93685158
94EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.92577710
95E2F1_18555785_ChIP-Seq_MESCs_Mouse0.92121860
96FUS_26573619_Chip-Seq_HEK293_Human0.91392002
97GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.91162296
98PHF8_20622853_ChIP-Seq_HELA_Human0.91075262
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90693035
100OCT4_21477851_ChIP-Seq_ESCs_Mouse0.89362495

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.64339913
2MP0001835_abnormal_antigen_presentation4.36762729
3MP0003195_calcinosis2.93024994
4MP0009785_altered_susceptibility_to2.90408241
5MP0005075_abnormal_melanosome_morpholog2.82832190
6MP0002166_altered_tumor_susceptibility2.64360882
7MP0003724_increased_susceptibility_to2.56049282
8MP0003806_abnormal_nucleotide_metabolis2.47553321
9MP0006072_abnormal_retinal_apoptosis2.30550424
10MP0002006_tumorigenesis2.28933080
11MP0001800_abnormal_humoral_immune2.28812710
12MP0005000_abnormal_immune_tolerance2.19782407
13MP0001790_abnormal_immune_system2.16365181
14MP0005387_immune_system_phenotype2.16365181
15MP0001873_stomach_inflammation2.15886215
16MP0000372_irregular_coat_pigmentation2.08026142
17MP0003693_abnormal_embryo_hatching2.05717855
18MP0000685_abnormal_immune_system1.99215404
19MP0002876_abnormal_thyroid_physiology1.98606186
20MP0009697_abnormal_copulation1.93990657
21MP0002723_abnormal_immune_serum1.88209918
22MP0001986_abnormal_taste_sensitivity1.87705270
23MP0005367_renal/urinary_system_phenotyp1.84483917
24MP0000516_abnormal_urinary_system1.84483917
25MP0001853_heart_inflammation1.80863745
26MP0004957_abnormal_blastocyst_morpholog1.77894889
27MP0002452_abnormal_antigen_presenting1.76249302
28MP0001819_abnormal_immune_cell1.75679298
29MP0002420_abnormal_adaptive_immunity1.74909335
30MP0006082_CNS_inflammation1.72686280
31MP0002102_abnormal_ear_morphology1.69957909
32MP0001348_abnormal_lacrimal_gland1.67738155
33MP0002254_reproductive_system_inflammat1.66826789
34MP0002148_abnormal_hypersensitivity_rea1.65522894
35MP0006036_abnormal_mitochondrial_physio1.65360838
36MP0005360_urolithiasis1.58685935
37MP0000569_abnormal_digit_pigmentation1.57431275
38MP0003011_delayed_dark_adaptation1.53788311
39MP0003448_altered_tumor_morphology1.53736746
40MP0005025_abnormal_response_to1.47781500
41MP0003786_premature_aging1.40237048
42MP0003950_abnormal_plasma_membrane1.39965113
43MP0004381_abnormal_hair_follicle1.38441188
44MP0003866_abnormal_defecation1.37197916
45MP0003283_abnormal_digestive_organ1.35022357
46MP0005253_abnormal_eye_physiology1.34328441
47MP0001845_abnormal_inflammatory_respons1.32431430
48MP0008875_abnormal_xenobiotic_pharmacok1.26961189
49MP0002398_abnormal_bone_marrow1.26627220
50MP0005332_abnormal_amino_acid1.24615322
51MP0009333_abnormal_splenocyte_physiolog1.23422604
52MP0004145_abnormal_muscle_electrophysio1.21917971
53MP0009764_decreased_sensitivity_to1.21466254
54MP0002837_dystrophic_cardiac_calcinosis1.17433749
55MP0000716_abnormal_immune_system1.16333227
56MP0005084_abnormal_gallbladder_morpholo1.11686080
57MP0003763_abnormal_thymus_physiology1.11621653
58MP0002138_abnormal_hepatobiliary_system1.10720264
59MP0003045_fibrosis1.10625764
60MP0002090_abnormal_vision1.07728879
61MP0002419_abnormal_innate_immunity1.04635667
62MP0005408_hypopigmentation1.00661507
63MP0002163_abnormal_gland_morphology0.99273721
64MP0010094_abnormal_chromosome_stability0.97085870
65MP0005174_abnormal_tail_pigmentation0.96736681
66MP0008872_abnormal_physiological_respon0.96523388
67MP0005310_abnormal_salivary_gland0.95769183
68MP0002429_abnormal_blood_cell0.95500145
69MP0009379_abnormal_foot_pigmentation0.94075819
70MP0008469_abnormal_protein_level0.93265410
71MP0001881_abnormal_mammary_gland0.92498194
72MP0001764_abnormal_homeostasis0.92490044
73MP0000689_abnormal_spleen_morphology0.92124839
74MP0008877_abnormal_DNA_methylation0.91630126
75MP0005636_abnormal_mineral_homeostasis0.91023875
76MP0010155_abnormal_intestine_physiology0.90136312
77MP0002234_abnormal_pharynx_morphology0.89215896
78MP0001905_abnormal_dopamine_level0.88847145
79MP0003646_muscle_fatigue0.87225192
80MP0001188_hyperpigmentation0.86740660
81MP0005646_abnormal_pituitary_gland0.85655322
82MP0005645_abnormal_hypothalamus_physiol0.83261507
83MP0005379_endocrine/exocrine_gland_phen0.82695214
84MP0000371_diluted_coat_color0.82580037
85MP0002693_abnormal_pancreas_physiology0.81913865
86MP0002638_abnormal_pupillary_reflex0.81663748
87MP0002405_respiratory_system_inflammati0.81588523
88MP0003186_abnormal_redox_activity0.81311542
89MP0002277_abnormal_respiratory_mucosa0.81278558
90MP0008007_abnormal_cellular_replicative0.80936503
91MP0005551_abnormal_eye_electrophysiolog0.80223805
92MP0009763_increased_sensitivity_to0.78062762
93MP0002722_abnormal_immune_system0.77547892
94MP0002751_abnormal_autonomic_nervous0.77539266
95MP0003718_maternal_effect0.77176908
96MP0000858_altered_metastatic_potential0.70458189
97MP0004215_abnormal_myocardial_fiber0.70213832
98MP0001243_abnormal_dermal_layer0.69383195
99MP0000703_abnormal_thymus_morphology0.68772488
100MP0008058_abnormal_DNA_repair0.68762923

Predicted human phenotypes

RankGene SetZ-score
1Renal cortical cysts (HP:0000803)4.22231494
2Aplastic anemia (HP:0001915)3.97558634
3Acute necrotizing encephalopathy (HP:0006965)3.92994404
4IgG deficiency (HP:0004315)3.91330605
5Hypoproteinemia (HP:0003075)3.74066567
6Mitochondrial inheritance (HP:0001427)3.72959004
7Congenital, generalized hypertrichosis (HP:0004540)3.72528405
8Increased hepatocellular lipid droplets (HP:0006565)3.64901043
9Increased CSF lactate (HP:0002490)3.59101421
10Hepatocellular necrosis (HP:0001404)3.57545560
11Hepatic necrosis (HP:0002605)3.56036580
12Abnormality of the prostate (HP:0008775)3.54608578
13Acute encephalopathy (HP:0006846)3.44117619
14Short tibia (HP:0005736)3.40534126
15Progressive macrocephaly (HP:0004481)3.36796041
16Abnormal mitochondria in muscle tissue (HP:0008316)3.35110037
17Cerebral edema (HP:0002181)3.14933018
18Aplasia/Hypoplasia of the tibia (HP:0005772)3.09219444
19Lipid accumulation in hepatocytes (HP:0006561)3.08035602
20Increased IgM level (HP:0003496)3.07907003
21Hypothermia (HP:0002045)3.06780666
22Generalized aminoaciduria (HP:0002909)2.95070419
23Prostate neoplasm (HP:0100787)2.94243580
24Exertional dyspnea (HP:0002875)2.94234595
25Renal Fanconi syndrome (HP:0001994)2.92692287
26Abnormality of aspartate family amino acid metabolism (HP:0010899)2.85677704
27Abnormality of methionine metabolism (HP:0010901)2.76879645
283-Methylglutaconic aciduria (HP:0003535)2.74135037
29Molar tooth sign on MRI (HP:0002419)2.73189925
30Abnormality of midbrain morphology (HP:0002418)2.73189925
31Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.70374838
32Decreased activity of mitochondrial respiratory chain (HP:0008972)2.70374838
33Methylmalonic acidemia (HP:0002912)2.66400247
34Increased serum lactate (HP:0002151)2.66375176
35Abnormality of the renal cortex (HP:0011035)2.62192073
36Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.62054220
37Abnormal albumin level (HP:0012116)2.59978493
38Hypoalbuminemia (HP:0003073)2.59978493
39Type I transferrin isoform profile (HP:0003642)2.59470221
40Abnormality of T cell number (HP:0011839)2.52687680
41Stomatitis (HP:0010280)2.45874129
42T lymphocytopenia (HP:0005403)2.45487322
43Severe combined immunodeficiency (HP:0004430)2.40009552
44Elevated erythrocyte sedimentation rate (HP:0003565)2.33584584
45Congenital stationary night blindness (HP:0007642)2.31523111
46Abnormality of B cell number (HP:0010975)2.30844383
47Glycosuria (HP:0003076)2.23520754
48Abnormality of urine glucose concentration (HP:0011016)2.23520754
49Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.22296402
50Median cleft lip (HP:0000161)2.21652902
51Methylmalonic aciduria (HP:0012120)2.21084115
52Increased intramyocellular lipid droplets (HP:0012240)2.20048970
53Dicarboxylic aciduria (HP:0003215)2.16178059
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.16178059
55Encephalitis (HP:0002383)2.15794131
56Rectovaginal fistula (HP:0000143)2.14540771
57Rectal fistula (HP:0100590)2.14540771
58Optic disc pallor (HP:0000543)2.13014646
59Thyroiditis (HP:0100646)2.11896746
60Pancreatic cysts (HP:0001737)2.11819791
61Recurrent bronchitis (HP:0002837)2.10640056
62Lactic acidosis (HP:0003128)2.10115930
63Facial diplegia (HP:0001349)2.09725324
64Combined immunodeficiency (HP:0005387)2.03852650
65Bifid tongue (HP:0010297)2.01256066
66Abnormality of renal resorption (HP:0011038)2.00506008
67Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.99655310
68Respiratory failure (HP:0002878)1.99547550
69Respiratory difficulties (HP:0002880)1.98331510
70Increased serum pyruvate (HP:0003542)1.97379588
71B lymphocytopenia (HP:0010976)1.96349592
72Decreased central vision (HP:0007663)1.94384366
73Abnormality of male internal genitalia (HP:0000022)1.92968626
74Abnormality of lateral ventricle (HP:0030047)1.91015431
75Hemoptysis (HP:0002105)1.90503321
76Abolished electroretinogram (ERG) (HP:0000550)1.89468983
77Autoimmune hemolytic anemia (HP:0001890)1.89098522
78Leukodystrophy (HP:0002415)1.86612894
79Chronic sinusitis (HP:0011109)1.84943116
80Abnormality of the phalanges of the 5th finger (HP:0004213)1.84313205
81Abnormality of the labia minora (HP:0012880)1.84269126
82Pulmonary infiltrates (HP:0002113)1.84193979
83Pancytopenia (HP:0001876)1.82833314
84Microretrognathia (HP:0000308)1.81995869
85Abnormality of sulfur amino acid metabolism (HP:0004339)1.78493100
86Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.78275113
87Abnormal protein N-linked glycosylation (HP:0012347)1.78275113
88Abnormal protein glycosylation (HP:0012346)1.78275113
89Abnormal glycosylation (HP:0012345)1.78275113
90IgM deficiency (HP:0002850)1.77702901
91Neuroendocrine neoplasm (HP:0100634)1.76566620
92Conical tooth (HP:0000698)1.76446816
93Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.76337424
94Abnormality of alanine metabolism (HP:0010916)1.76337424
95Hyperalaninemia (HP:0003348)1.76337424
96Constricted visual fields (HP:0001133)1.74542486
97Pancreatic fibrosis (HP:0100732)1.73868136
98Posterior subcapsular cataract (HP:0007787)1.73819494
99Abnormality of T cells (HP:0002843)1.73036373
100Recurrent cutaneous fungal infections (HP:0011370)1.71266275

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.99264209
2TLK13.92777220
3NUAK13.12457558
4ZAK2.96886418
5BMPR22.83920729
6BUB12.50587405
7PLK42.39779431
8MAP3K122.32685733
9KDR2.27142838
10EIF2AK32.24013676
11MAP4K22.22915419
12MST42.12495936
13SCYL22.03824629
14CDK191.87404636
15TSSK61.86628337
16MYLK1.76821447
17VRK11.74280817
18FRK1.58339013
19GRK11.57682679
20TRIM281.49559723
21BRSK21.42916517
22BCKDK1.37947788
23ITK1.35687328
24ERBB31.34892686
25RPS6KA41.33760463
26PLK31.33461476
27TRPM71.31530660
28GRK61.30259466
29OXSR11.29981579
30IKBKB1.27452754
31PBK1.26739668
32FES1.21921283
33NEK11.21816402
34ADRBK21.18731370
35PASK1.11647862
36TEC1.10481527
37MAP2K61.09070896
38NEK21.06970539
39MAP4K10.99668023
40MAP3K140.98543890
41CCNB10.98153371
42WNK30.94652371
43EIF2AK20.93278337
44LIMK10.92788386
45CSF1R0.89702781
46DAPK10.88250653
47VRK20.87820206
48MAP2K20.86359308
49TAOK30.86085608
50MATK0.85477676
51TTK0.83739229
52MKNK20.83322435
53WNK40.81307617
54SRPK10.80989947
55SYK0.78672240
56LATS10.77988476
57ACVR1B0.77605808
58PLK10.77149127
59GRK70.76518930
60AURKB0.75202683
61ILK0.74713402
62WEE10.74510725
63MAPKAPK30.73471814
64CAMKK20.65977589
65TAF10.65794731
66LCK0.64242526
67LYN0.64016393
68NLK0.63789213
69ROCK10.63040548
70PHKG20.62090959
71PHKG10.62090959
72PIK3CG0.61896789
73CDC70.61009513
74TNIK0.60430665
75IGF1R0.54580532
76CSNK1G30.54323045
77BTK0.54278320
78PIM10.53189780
79KIT0.52458231
80MKNK10.51710477
81TYK20.48943174
82IKBKE0.48254883
83STK30.47051025
84JAK30.46623950
85PLK20.46244971
86PRKCQ0.44737450
87RPS6KA50.44515741
88ATR0.44415368
89INSRR0.43534520
90PAK10.42534565
91CDK30.41055826
92CSK0.41009477
93CSNK2A10.40651006
94STK390.39265017
95PNCK0.38824817
96CSNK1G10.37599988
97STK100.36977063
98EIF2AK10.36975270
99ERBB20.36821689
100CHUK0.36585466

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.40669663
2Allograft rejection_Homo sapiens_hsa053304.12211530
3Autoimmune thyroid disease_Homo sapiens_hsa053204.08952861
4Graft-versus-host disease_Homo sapiens_hsa053323.94774207
5Proteasome_Homo sapiens_hsa030503.61219581
6Type I diabetes mellitus_Homo sapiens_hsa049403.36716563
7Intestinal immune network for IgA production_Homo sapiens_hsa046723.05076860
8Protein export_Homo sapiens_hsa030602.89263460
9Oxidative phosphorylation_Homo sapiens_hsa001902.59673293
10Antigen processing and presentation_Homo sapiens_hsa046122.50868235
11RNA polymerase_Homo sapiens_hsa030202.22672556
12Parkinsons disease_Homo sapiens_hsa050122.10256231
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.07581245
14Primary immunodeficiency_Homo sapiens_hsa053402.01289142
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.00944466
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.73037738
17Ribosome_Homo sapiens_hsa030101.65612660
18One carbon pool by folate_Homo sapiens_hsa006701.61536585
19Viral myocarditis_Homo sapiens_hsa054161.57920711
20RNA degradation_Homo sapiens_hsa030181.53514933
21Rheumatoid arthritis_Homo sapiens_hsa053231.41536003
22Homologous recombination_Homo sapiens_hsa034401.31334712
23Huntingtons disease_Homo sapiens_hsa050161.24306879
24Staphylococcus aureus infection_Homo sapiens_hsa051501.19979704
25Regulation of autophagy_Homo sapiens_hsa041401.16830808
26RNA transport_Homo sapiens_hsa030131.14112548
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.13282634
28Hematopoietic cell lineage_Homo sapiens_hsa046401.08968229
29Leishmaniasis_Homo sapiens_hsa051401.06058325
30Alzheimers disease_Homo sapiens_hsa050101.05690019
31Spliceosome_Homo sapiens_hsa030401.03755107
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.02465749
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.99371841
34Purine metabolism_Homo sapiens_hsa002300.97997916
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97757947
36Propanoate metabolism_Homo sapiens_hsa006400.96758449
37Maturity onset diabetes of the young_Homo sapiens_hsa049500.96662347
38Nitrogen metabolism_Homo sapiens_hsa009100.93028098
39Mismatch repair_Homo sapiens_hsa034300.92736653
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.90474631
41Systemic lupus erythematosus_Homo sapiens_hsa053220.83434644
42Tryptophan metabolism_Homo sapiens_hsa003800.83019425
43NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81171752
44DNA replication_Homo sapiens_hsa030300.80902459
45Pyrimidine metabolism_Homo sapiens_hsa002400.80799178
46Fanconi anemia pathway_Homo sapiens_hsa034600.78829297
47Linoleic acid metabolism_Homo sapiens_hsa005910.78418561
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78319627
49Cardiac muscle contraction_Homo sapiens_hsa042600.75408659
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.74991790
51Butanoate metabolism_Homo sapiens_hsa006500.74032037
52Sulfur metabolism_Homo sapiens_hsa009200.69688937
53Herpes simplex infection_Homo sapiens_hsa051680.69411813
54Caffeine metabolism_Homo sapiens_hsa002320.68158423
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67552580
56T cell receptor signaling pathway_Homo sapiens_hsa046600.65615818
57Phototransduction_Homo sapiens_hsa047440.64398156
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63969555
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63545458
60Epstein-Barr virus infection_Homo sapiens_hsa051690.61911535
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61879949
62Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.61165404
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58479691
64Chemical carcinogenesis_Homo sapiens_hsa052040.54217208
65Legionellosis_Homo sapiens_hsa051340.54057903
66Collecting duct acid secretion_Homo sapiens_hsa049660.52854071
67Fatty acid elongation_Homo sapiens_hsa000620.52805141
68Selenocompound metabolism_Homo sapiens_hsa004500.51436816
69Ether lipid metabolism_Homo sapiens_hsa005650.48290114
70Basal transcription factors_Homo sapiens_hsa030220.44986112
71Fat digestion and absorption_Homo sapiens_hsa049750.44347721
72Fatty acid degradation_Homo sapiens_hsa000710.44315327
73Sulfur relay system_Homo sapiens_hsa041220.43393425
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42604404
75Steroid biosynthesis_Homo sapiens_hsa001000.42067838
76Shigellosis_Homo sapiens_hsa051310.40657092
77Measles_Homo sapiens_hsa051620.40196032
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39524489
79N-Glycan biosynthesis_Homo sapiens_hsa005100.34403903
80Metabolic pathways_Homo sapiens_hsa011000.32296268
81Toxoplasmosis_Homo sapiens_hsa051450.32254840
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31668004
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31282129
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30043529
85Retinol metabolism_Homo sapiens_hsa008300.29388904
86Peroxisome_Homo sapiens_hsa041460.29173222
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.27582364
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27235265
89Nucleotide excision repair_Homo sapiens_hsa034200.27075052
90beta-Alanine metabolism_Homo sapiens_hsa004100.25910978
91Fatty acid metabolism_Homo sapiens_hsa012120.25438546
922-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.25262517
93Olfactory transduction_Homo sapiens_hsa047400.24884136
94Phagosome_Homo sapiens_hsa041450.24803359
95Arachidonic acid metabolism_Homo sapiens_hsa005900.24328147
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.24138913
97Glutathione metabolism_Homo sapiens_hsa004800.24052501
98Influenza A_Homo sapiens_hsa051640.23315014
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.20110009
100Tuberculosis_Homo sapiens_hsa051520.18236369

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