SNX6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with the long isoform of the leptin receptor, the transforming growth factor-beta family of receptor serine-threonine kinases, and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor. This protein may form oligomeric complexes with family member proteins through interactions of both the PX domain and the coiled coil regions of the molecules. Translocation of this protein from the cytoplasm to the nucleus occurs after binding to proviral integration site 1 protein. This gene results in two transcripts encoding two distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to mitochondrial membrane (GO:0090151)4.86407955
2axon ensheathment in central nervous system (GO:0032291)4.74617857
3central nervous system myelination (GO:0022010)4.74617857
4sequestering of actin monomers (GO:0042989)4.72221618
5protein neddylation (GO:0045116)4.64848575
6proteasome assembly (GO:0043248)4.44199211
77-methylguanosine mRNA capping (GO:0006370)4.18401293
8RNA capping (GO:0036260)4.16908678
97-methylguanosine RNA capping (GO:0009452)4.16908678
10termination of RNA polymerase III transcription (GO:0006386)4.10663582
11transcription elongation from RNA polymerase III promoter (GO:0006385)4.10663582
12cullin deneddylation (GO:0010388)4.09651910
13negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.96710881
14platelet dense granule organization (GO:0060155)3.78741227
15negative regulation of ligase activity (GO:0051352)3.76887987
16negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.76887987
17positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.73088563
18protein deneddylation (GO:0000338)3.70302493
19regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.61504578
20DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.54389782
21anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.52647860
22signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.47525624
23intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.47525624
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.46546267
25signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.45997821
26signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.45997821
27signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.45997821
28fatty acid elongation (GO:0030497)3.43376384
29transcription elongation from RNA polymerase I promoter (GO:0006362)3.41983222
30retina vasculature morphogenesis in camera-type eye (GO:0061299)3.39043365
31signal transduction involved in DNA damage checkpoint (GO:0072422)3.36020362
32signal transduction involved in DNA integrity checkpoint (GO:0072401)3.36020362
33signal transduction involved in cell cycle checkpoint (GO:0072395)3.33889281
34regulation of cellular amino acid metabolic process (GO:0006521)3.33299240
35long-chain fatty acid biosynthetic process (GO:0042759)3.31120253
36antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.28822808
37regulation of mononuclear cell migration (GO:0071675)3.21770506
38termination of RNA polymerase I transcription (GO:0006363)3.21591311
39cholesterol biosynthetic process (GO:0006695)3.20460972
40cell adhesion mediated by integrin (GO:0033627)3.18678228
41organelle disassembly (GO:1903008)3.18512271
42positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.18325349
43transcription from RNA polymerase I promoter (GO:0006360)3.17985071
44regulation of integrin-mediated signaling pathway (GO:2001044)3.16294296
45L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.15256766
46positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.14702416
47mitotic G2/M transition checkpoint (GO:0044818)3.12438802
48ribosomal small subunit biogenesis (GO:0042274)3.11470239
49transcription initiation from RNA polymerase I promoter (GO:0006361)3.09077689
50blastocyst development (GO:0001824)3.09024905
51isoprenoid biosynthetic process (GO:0008299)3.08996660
52positive regulation of ligase activity (GO:0051351)3.05737050
53mitotic G2 DNA damage checkpoint (GO:0007095)3.05541805
54female gonad development (GO:0008585)3.02701465
55transcription-coupled nucleotide-excision repair (GO:0006283)2.99771598
56transcription elongation from RNA polymerase II promoter (GO:0006368)2.98528694
57purine nucleobase biosynthetic process (GO:0009113)2.98152130
58ganglion development (GO:0061548)2.97144540
59membrane budding (GO:0006900)2.96851018
60sterol biosynthetic process (GO:0016126)2.96337158
61mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.95918132
62regulation of cytokine secretion involved in immune response (GO:0002739)2.91498816
63substrate-dependent cell migration (GO:0006929)2.88195995
64metaphase plate congression (GO:0051310)2.88089472
65positive regulation of viral transcription (GO:0050434)2.87819838
66regulation of chemokine-mediated signaling pathway (GO:0070099)2.86953830
67tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.86545764
68RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.86545764
69phagocytosis, engulfment (GO:0006911)2.86154493
70regulation of ubiquitin-protein transferase activity (GO:0051438)2.83118876
71DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.82983843
72CENP-A containing nucleosome assembly (GO:0034080)2.82921385
73protein K11-linked ubiquitination (GO:0070979)2.81268423
74maturation of SSU-rRNA (GO:0030490)2.80341767
75myelination (GO:0042552)2.79734806
76DNA-templated transcription, elongation (GO:0006354)2.77650787
77ensheathment of neurons (GO:0007272)2.77329040
78axon ensheathment (GO:0008366)2.77329040
79positive regulation of cell cycle arrest (GO:0071158)2.77013042
80regulation of ligase activity (GO:0051340)2.76996563
81ribonucleoprotein complex disassembly (GO:0032988)2.75736919
82response to X-ray (GO:0010165)2.75585074
83neutrophil activation involved in immune response (GO:0002283)2.75323273
84ribosomal large subunit biogenesis (GO:0042273)2.74120722
85antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.73629889
86ribosome assembly (GO:0042255)2.72130678
87adenosine metabolic process (GO:0046085)2.71266416
88mitotic metaphase plate congression (GO:0007080)2.71064558
89protein K6-linked ubiquitination (GO:0085020)2.71039220
90DNA damage response, detection of DNA damage (GO:0042769)2.70397397
91mannosylation (GO:0097502)2.69667249
92positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.69098452
93regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.69098452
94keratinocyte development (GO:0003334)2.67971956
95positive regulation of actin filament depolymerization (GO:0030836)2.67259206
96establishment of integrated proviral latency (GO:0075713)2.67209774
97regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.66937271
98DNA double-strand break processing (GO:0000729)2.65988369
99energy coupled proton transport, down electrochemical gradient (GO:0015985)2.65524351
100ATP synthesis coupled proton transport (GO:0015986)2.65524351
101signal peptide processing (GO:0006465)2.65346171
102NADH dehydrogenase complex assembly (GO:0010257)2.64711343
103mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.64711343
104mitochondrial respiratory chain complex I assembly (GO:0032981)2.64711343
105microtubule polymerization or depolymerization (GO:0031109)2.64366942
106ribosomal small subunit assembly (GO:0000028)2.64210032
107cranial suture morphogenesis (GO:0060363)2.63952565
108regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.63757487
109nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.63535930
110membrane invagination (GO:0010324)2.62507205
111formation of translation preinitiation complex (GO:0001731)2.61091662
112establishment of chromosome localization (GO:0051303)2.60752927
113nucleobase biosynthetic process (GO:0046112)2.60232037
114craniofacial suture morphogenesis (GO:0097094)2.59621930
115regulation of non-canonical Wnt signaling pathway (GO:2000050)2.59512513
116neuron projection extension involved in neuron projection guidance (GO:1902284)2.59193182
117axon extension involved in axon guidance (GO:0048846)2.59193182
118regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.58876577
119regulation of metalloenzyme activity (GO:0048552)2.58683923
120chromatin remodeling at centromere (GO:0031055)2.58475888
121establishment of viral latency (GO:0019043)2.58103927
122GPI anchor biosynthetic process (GO:0006506)2.56980687
123viral mRNA export from host cell nucleus (GO:0046784)2.52332996
124chaperone-mediated protein transport (GO:0072321)2.51042877
125cellular response to vitamin D (GO:0071305)2.50861827
126translation (GO:0006412)2.50697588
127cellular response to interferon-alpha (GO:0035457)2.50416658
128ribonucleoprotein complex biogenesis (GO:0022613)2.50384594
129amyloid precursor protein metabolic process (GO:0042982)2.50254535
130exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.49936452
131water-soluble vitamin biosynthetic process (GO:0042364)2.49792119
132eosinophil chemotaxis (GO:0048245)2.49228937
133neural tube formation (GO:0001841)2.48848335
134signal transduction in response to DNA damage (GO:0042770)2.48795164
135G1/S transition of mitotic cell cycle (GO:0000082)2.48168531
136cell cycle G1/S phase transition (GO:0044843)2.48168531
137negative regulation of protein ubiquitination (GO:0031397)2.47397443
138DNA ligation (GO:0006266)2.46988296
139myelin assembly (GO:0032288)2.46949199
140positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.46690121
141mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.46690121
142histamine secretion (GO:0001821)2.45430110
143folic acid transport (GO:0015884)2.41081406
144de novo protein folding (GO:0006458)2.40302185
145spindle checkpoint (GO:0031577)2.38646738
146protein heterotetramerization (GO:0051290)2.33842853
147ventricular cardiac muscle cell development (GO:0055015)2.31032502
148de novo posttranslational protein folding (GO:0051084)2.27675513
149vesicle fusion (GO:0006906)2.25552985
150response to redox state (GO:0051775)2.24705298
151mitotic spindle checkpoint (GO:0071174)2.22806379

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.72722765
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.71203925
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.36676420
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.93950191
5CREB1_15753290_ChIP-ChIP_HEK293T_Human3.75838284
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.72161688
7CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.45753958
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.37747168
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.37168440
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.30112333
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.22758818
12ETS1_20019798_ChIP-Seq_JURKAT_Human3.08279165
13MYC_18555785_ChIP-Seq_MESCs_Mouse3.04271088
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.97336773
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.95571764
16E2F7_22180533_ChIP-Seq_HELA_Human2.78973079
17ELK1_19687146_ChIP-ChIP_HELA_Human2.66523399
18VDR_23849224_ChIP-Seq_CD4+_Human2.59910274
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.39556216
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.29154109
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.16512578
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.15636249
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.12176902
24RBPJ_22232070_ChIP-Seq_NCS_Mouse2.11795460
25* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10905988
26FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.10218729
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.08756312
28E2F4_17652178_ChIP-ChIP_JURKAT_Human2.08252860
29E2F1_18555785_ChIP-Seq_MESCs_Mouse2.06024359
30DCP1A_22483619_ChIP-Seq_HELA_Human2.05796031
31SRF_21415370_ChIP-Seq_HL-1_Mouse2.05265469
32SMAD_19615063_ChIP-ChIP_OVARY_Human2.00697780
33* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.97414025
34MYC_19079543_ChIP-ChIP_MESCs_Mouse1.95692570
35FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.92893403
36FOXP3_21729870_ChIP-Seq_TREG_Human1.89547564
37* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.88261901
38IRF8_21731497_ChIP-ChIP_J774_Mouse1.86517625
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83849630
40XRN2_22483619_ChIP-Seq_HELA_Human1.81445988
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79329362
42AR_21909140_ChIP-Seq_LNCAP_Human1.78716862
43TAF15_26573619_Chip-Seq_HEK293_Human1.77192823
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.74326846
45CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.74298436
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.72964348
47GABP_19822575_ChIP-Seq_HepG2_Human1.62285695
48ELK1_22589737_ChIP-Seq_MCF10A_Human1.61885155
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61535888
50BRD4_25478319_ChIP-Seq_HGPS_Human1.59968861
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.59428794
52TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.59208812
53TTF2_22483619_ChIP-Seq_HELA_Human1.57803103
54* SOX17_20123909_ChIP-Seq_XEN_Mouse1.56040134
55P300_19829295_ChIP-Seq_ESCs_Human1.53449763
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52868661
57SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.52863561
58ZNF274_21170338_ChIP-Seq_K562_Hela1.48654637
59HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.45154447
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.44388497
61Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.43589546
62ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.43264446
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.41244391
64NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.40290584
65NRF2_20460467_ChIP-Seq_MEFs_Mouse1.40290584
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39861444
67YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38366577
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37248467
69POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36699709
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36698702
71YY1_21170310_ChIP-Seq_MESCs_Mouse1.34753996
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33260618
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32866830
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32281404
75* CJUN_26792858_Chip-Seq_BT549_Human1.32116235
76IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.29276230
77SALL4_18804426_ChIP-ChIP_XEN_Mouse1.27770506
78MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23171987
79PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23152272
80TRIM28_21343339_ChIP-Seq_HEK293_Human1.21535182
81MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20364670
82PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19926400
83RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.19517083
84NFE2_27457419_Chip-Seq_LIVER_Mouse1.18369991
85FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17689075
86* SPI1_23547873_ChIP-Seq_NB4_Human1.17477273
87NANOG_18555785_Chip-Seq_ESCs_Mouse1.16749527
88VDR_22108803_ChIP-Seq_LS180_Human1.15132084
89CRX_20693478_ChIP-Seq_RETINA_Mouse1.14217086
90* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13396287
91IGF1R_20145208_ChIP-Seq_DFB_Human1.13305418
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12373661
93EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11202957
94HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.09888779
95TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.08002121
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07097363
97WT1_19549856_ChIP-ChIP_CCG9911_Human1.06802682
98TP53_18474530_ChIP-ChIP_U2OS_Human1.06162741
99SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06115380
100SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04548918
101CMYC_18555785_Chip-Seq_ESCs_Mouse1.04033598
102CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03393986
103FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03060073
104CBP_20019798_ChIP-Seq_JUKART_Human1.01677772
105IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01677772
106CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01575160
107PIAS1_25552417_ChIP-Seq_VCAP_Human0.98658333
108KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.97608092
109CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97477709
110E2F1_18555785_Chip-Seq_ESCs_Mouse0.96331699
111EWS_26573619_Chip-Seq_HEK293_Human0.96217106
112MYC_18940864_ChIP-ChIP_HL60_Human0.95128848
113ZFX_18555785_ChIP-Seq_MESCs_Mouse0.94705992
114TFEB_21752829_ChIP-Seq_HELA_Human0.94694542
115KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94683428
116P53_22387025_ChIP-Seq_ESCs_Mouse0.93763408
117TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93578806
118POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93493067
119SALL4_22934838_ChIP-ChIP_CD34+_Human0.93425393
120EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.92449984
121NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.92075425
122P300_18555785_Chip-Seq_ESCs_Mouse0.91259059
123CDX2_22108803_ChIP-Seq_LS180_Human0.90978862
124* NANOG_19829295_ChIP-Seq_ESCs_Human0.90857387
125NANOG_18555785_ChIP-Seq_MESCs_Mouse0.89779166
126SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89000309
127CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.87009538
128BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86542079
129KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.85799304
130KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.85799304
131KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.85799304
132FUS_26573619_Chip-Seq_HEK293_Human0.83855484
133* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.83397104
134SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.82306873
135KDM5A_27292631_Chip-Seq_BREAST_Human0.81869965
136BP1_19119308_ChIP-ChIP_Hs578T_Human0.81473144
137IRF1_19129219_ChIP-ChIP_H3396_Human0.81309147
138STAT4_19710469_ChIP-ChIP_TH1__Mouse0.79436004
139NANOG_16153702_ChIP-ChIP_HESCs_Human0.79172233
140FLI1_27457419_Chip-Seq_LIVER_Mouse0.78244803
141TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.77938816
142SOX2_16153702_ChIP-ChIP_HESCs_Human0.77678768
143SALL1_21062744_ChIP-ChIP_HESCs_Human0.77048803
144FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.75117293
145SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.74179919
146STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.71739456
147EOMES_21245162_ChIP-Seq_HESCs_Human0.71145790
148CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.71102800
149PCGF2_27294783_Chip-Seq_ESCs_Mouse0.70031517

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination2.68541240
2MP0004957_abnormal_blastocyst_morpholog2.60818787
3MP0003693_abnormal_embryo_hatching2.58052791
4MP0008438_abnormal_cutaneous_collagen2.57390086
5MP0008057_abnormal_DNA_replication2.56650966
6MP0008932_abnormal_embryonic_tissue2.51710990
7MP0005171_absent_coat_pigmentation2.46921797
8MP0008260_abnormal_autophagy2.41682313
9MP0000372_irregular_coat_pigmentation2.38419340
10MP0003941_abnormal_skin_development2.34681077
11MP0003136_yellow_coat_color2.32789326
12MP0005084_abnormal_gallbladder_morpholo2.24728934
13MP0005275_abnormal_skin_tensile2.20170755
14MP0003718_maternal_effect2.15080207
15MP0003950_abnormal_plasma_membrane2.11340589
16MP0003077_abnormal_cell_cycle2.08676614
17MP0008058_abnormal_DNA_repair2.08206173
18MP0000569_abnormal_digit_pigmentation2.07517695
19MP0001905_abnormal_dopamine_level2.01266283
20MP0008789_abnormal_olfactory_epithelium1.94815426
21MP0008877_abnormal_DNA_methylation1.93045607
22MP0010094_abnormal_chromosome_stability1.92613818
23MP0002148_abnormal_hypersensitivity_rea1.92122985
24MP0008007_abnormal_cellular_replicative1.88383194
25MP0005058_abnormal_lysosome_morphology1.80617479
26MP0003315_abnormal_perineum_morphology1.76710427
27MP0002233_abnormal_nose_morphology1.76050364
28MP0003890_abnormal_embryonic-extraembry1.73939158
29MP0002938_white_spotting1.73312760
30MP0001529_abnormal_vocalization1.72346118
31MP0005408_hypopigmentation1.70193741
32MP0001542_abnormal_bone_strength1.63612984
33MP0009333_abnormal_splenocyte_physiolog1.63168651
34MP0003123_paternal_imprinting1.59402764
35MP0003448_altered_tumor_morphology1.59126504
36MP0002234_abnormal_pharynx_morphology1.58013891
37MP0005257_abnormal_intraocular_pressure1.54771123
38MP0005367_renal/urinary_system_phenotyp1.54128871
39MP0000516_abnormal_urinary_system1.54128871
40MP0010352_gastrointestinal_tract_polyps1.50042871
41MP0006054_spinal_hemorrhage1.49918362
42MP0001485_abnormal_pinna_reflex1.49558439
43MP0005164_abnormal_response_to1.49307417
44MP0009053_abnormal_anal_canal1.45624758
45MP0004883_abnormal_blood_vessel1.45555029
46MP0010368_abnormal_lymphatic_system1.44737012
47MP0002254_reproductive_system_inflammat1.42127601
48MP0003121_genomic_imprinting1.41561874
49MP0003786_premature_aging1.40552416
50MP0005503_abnormal_tendon_morphology1.39832720
51MP0003111_abnormal_nucleus_morphology1.38744781
52MP0005248_abnormal_Harderian_gland1.37165979
53MP0006082_CNS_inflammation1.36673529
54MP0003191_abnormal_cellular_cholesterol1.35699306
55MP0002090_abnormal_vision1.34911847
56MP0001835_abnormal_antigen_presentation1.33746321
57MP0003566_abnormal_cell_adhesion1.30728426
58MP0001879_abnormal_lymphatic_vessel1.30388815
59MP0009785_altered_susceptibility_to1.29092934
60MP0003279_aneurysm1.28842066
61MP0009697_abnormal_copulation1.27103967
62MP0002163_abnormal_gland_morphology1.26028252
63MP0005197_abnormal_uvea_morphology1.24683278
64MP0001986_abnormal_taste_sensitivity1.22232853
65MP0005671_abnormal_response_to1.20947724
66MP0003937_abnormal_limbs/digits/tail_de1.20814834
67MP0003755_abnormal_palate_morphology1.20458424
68MP0003828_pulmonary_edema1.19537940
69MP0001853_heart_inflammation1.15940960
70MP0003567_abnormal_fetal_cardiomyocyte1.15822414
71MP0003186_abnormal_redox_activity1.15332202
72MP0001727_abnormal_embryo_implantation1.14455604
73MP0009379_abnormal_foot_pigmentation1.13468591
74MP0003221_abnormal_cardiomyocyte_apopto1.12712308
75MP0001286_abnormal_eye_development1.12230924
76MP0002277_abnormal_respiratory_mucosa1.09632249
77MP0000767_abnormal_smooth_muscle1.06981603
78MP0002282_abnormal_trachea_morphology1.06845073
79MP0010030_abnormal_orbit_morphology1.03792024
80MP0004742_abnormal_vestibular_system1.03763542
81MP0000358_abnormal_cell_content/1.03434477
82MP0010307_abnormal_tumor_latency1.03101962
83MP0005000_abnormal_immune_tolerance1.02938397
84MP0001915_intracranial_hemorrhage1.02428556
85MP0003938_abnormal_ear_development1.01301590
86MP0002102_abnormal_ear_morphology1.00771448
87MP0001730_embryonic_growth_arrest0.99981088
88MP0002419_abnormal_innate_immunity0.98610925
89MP0000383_abnormal_hair_follicle0.98249022
90MP0005394_taste/olfaction_phenotype0.98231611
91MP0005499_abnormal_olfactory_system0.98231611
92MP0000566_synostosis0.97530107
93MP0004147_increased_porphyrin_level0.97478346
94MP0005023_abnormal_wound_healing0.94912657
95MP0003634_abnormal_glial_cell0.94521986
96MP0003806_abnormal_nucleotide_metabolis0.94241179
97MP0004272_abnormal_basement_membrane0.93789960
98MP0003195_calcinosis0.93408786
99MP0009764_decreased_sensitivity_to0.91849048
100MP0002396_abnormal_hematopoietic_system0.91779631
101MP0004134_abnormal_chest_morphology0.91058580
102MP0003724_increased_susceptibility_to0.90958236
103MP0005409_darkened_coat_color0.90956533
104MP0000465_gastrointestinal_hemorrhage0.90245374
105MP0002295_abnormal_pulmonary_circulatio0.89987962
106MP0003690_abnormal_glial_cell0.89546904
107MP0003705_abnormal_hypodermis_morpholog0.89467203
108MP0002210_abnormal_sex_determination0.88319989
109MP0003385_abnormal_body_wall0.88188132
110MP0000462_abnormal_digestive_system0.87983019
111MP0001661_extended_life_span0.87682230
112MP0005193_abnormal_anterior_eye0.86749787
113MP0009780_abnormal_chondrocyte_physiolo0.85891774
114MP0002452_abnormal_antigen_presenting0.85335473
115MP0001299_abnormal_eye_distance/0.84915282
116MP0002933_joint_inflammation0.82603811
117MP0000343_altered_response_to0.82565748
118MP0002896_abnormal_bone_mineralization0.80755074
119MP0000537_abnormal_urethra_morphology0.80244236
120MP0002697_abnormal_eye_size0.79308361
121MP0005025_abnormal_response_to0.78790471
122MP0006072_abnormal_retinal_apoptosis0.78234359
123MP0000350_abnormal_cell_proliferation0.78012798
124MP0002420_abnormal_adaptive_immunity0.77085072
125MP0002723_abnormal_immune_serum0.76510175
126MP0000015_abnormal_ear_pigmentation0.76202044
127MP0001243_abnormal_dermal_layer0.75961094
128MP0001819_abnormal_immune_cell0.75221508
129MP0000681_abnormal_thyroid_gland0.75158382
130MP0005623_abnormal_meninges_morphology0.75084786
131MP0000432_abnormal_head_morphology0.73642130
132MP0002109_abnormal_limb_morphology0.73249958
133MP0001324_abnormal_eye_pigmentation0.72730663
134MP0002095_abnormal_skin_pigmentation0.72390905
135MP0002132_abnormal_respiratory_system0.71892770
136MP0001145_abnormal_male_reproductive0.71416975
137MP0009250_abnormal_appendicular_skeleto0.71228856
138MP0002751_abnormal_autonomic_nervous0.70865681
139MP0003878_abnormal_ear_physiology0.70212942
140MP0005377_hearing/vestibular/ear_phenot0.70212942
141MP0003632_abnormal_nervous_system0.70082482
142MP0005395_other_phenotype0.69949304
143MP0002084_abnormal_developmental_patter0.69804976
144MP0001119_abnormal_female_reproductive0.69485373
145MP0002092_abnormal_eye_morphology0.68240165
146MP0005508_abnormal_skeleton_morphology0.67974060
147MP0003122_maternal_imprinting0.67633363
148MP0000647_abnormal_sebaceous_gland0.66816164
149MP0010678_abnormal_skin_adnexa0.66366558
150MP0008004_abnormal_stomach_pH0.66003357
151MP0000163_abnormal_cartilage_morphology0.65729741
152MP0000313_abnormal_cell_death0.64851440
153MP0001293_anophthalmia0.64830260
154MP0001697_abnormal_embryo_size0.64249989
155MP0005451_abnormal_body_composition0.64056122

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)4.12935937
2Increased serum pyruvate (HP:0003542)4.06828452
3Abnormality of glycolysis (HP:0004366)4.06828452
4Cerebral hypomyelination (HP:0006808)3.91517004
5Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.76638391
6Acute necrotizing encephalopathy (HP:0006965)3.09886978
7Autoamputation (HP:0001218)3.08290230
8Mitochondrial inheritance (HP:0001427)3.06612128
9Papillary thyroid carcinoma (HP:0002895)3.06152104
103-Methylglutaconic aciduria (HP:0003535)2.99883150
11Increased hepatocellular lipid droplets (HP:0006565)2.99388002
12Hepatocellular necrosis (HP:0001404)2.99101480
13Disinhibition (HP:0000734)2.98632531
14Abnormality of chromosome stability (HP:0003220)2.96115858
15Renal Fanconi syndrome (HP:0001994)2.92735577
16Meckel diverticulum (HP:0002245)2.92096305
17Birth length less than 3rd percentile (HP:0003561)2.86448543
18Premature rupture of membranes (HP:0001788)2.83460962
19Nausea (HP:0002018)2.82641900
20Abnormality of the ileum (HP:0001549)2.78482278
21Breast hypoplasia (HP:0003187)2.78273340
22Stenosis of the external auditory canal (HP:0000402)2.72673440
23Congenital ichthyosiform erythroderma (HP:0007431)2.69738949
24Chromosomal breakage induced by crosslinking agents (HP:0003221)2.69729483
25Aplastic anemia (HP:0001915)2.69354591
26Thyroid carcinoma (HP:0002890)2.64401363
27Segmental peripheral demyelination/remyelination (HP:0003481)2.62801775
28Adrenal hypoplasia (HP:0000835)2.62540390
29Chromsome breakage (HP:0040012)2.59434461
30Abnormality of methionine metabolism (HP:0010901)2.53106987
31Increased CSF lactate (HP:0002490)2.52657115
32Aplasia/Hypoplasia of the uvula (HP:0010293)2.50009730
33Abnormal mitochondria in muscle tissue (HP:0008316)2.47977978
34Lipid accumulation in hepatocytes (HP:0006561)2.47420228
35Postnatal microcephaly (HP:0005484)2.45145423
36Hepatic necrosis (HP:0002605)2.45128258
37Bifid tongue (HP:0010297)2.43246874
38Progressive macrocephaly (HP:0004481)2.43049064
39Vertebral hypoplasia (HP:0008417)2.42939054
40Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.42939054
41Abnormality of cells of the erythroid lineage (HP:0012130)2.39083183
42Congenital, generalized hypertrichosis (HP:0004540)2.37578864
43Supernumerary spleens (HP:0009799)2.36737514
44Prolonged neonatal jaundice (HP:0006579)2.36516445
45Carpal bone hypoplasia (HP:0001498)2.34381429
46Hypoplasia of the capital femoral epiphysis (HP:0003090)2.34138030
47Patchy hypopigmentation of hair (HP:0011365)2.33427244
48Hepatosplenomegaly (HP:0001433)2.30825863
49Abnormality of the preputium (HP:0100587)2.28344790
50Disproportionate short-trunk short stature (HP:0003521)2.27209322
51CNS hypomyelination (HP:0003429)2.26601532
52Type I transferrin isoform profile (HP:0003642)2.26422598
53Leukodystrophy (HP:0002415)2.25557761
54Exertional dyspnea (HP:0002875)2.24420255
55Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.24214432
56Vacuolated lymphocytes (HP:0001922)2.22815579
57Abnormal number of erythroid precursors (HP:0012131)2.22242025
58Delayed epiphyseal ossification (HP:0002663)2.22239619
59Cortical dysplasia (HP:0002539)2.22229201
60Degeneration of the lateral corticospinal tracts (HP:0002314)2.20476735
61Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.20476735
62Abnormality of liposaccharide metabolism (HP:0010968)2.16779251
63Abnormality of glycosphingolipid metabolism (HP:0004343)2.16779251
64Abnormality of glycolipid metabolism (HP:0010969)2.16779251
65Hypoplastic pelvis (HP:0008839)2.16303279
66Irregular epiphyses (HP:0010582)2.15776941
67Abnormality of aspartate family amino acid metabolism (HP:0010899)2.15433322
68Abnormal trabecular bone morphology (HP:0100671)2.11346154
69Oral leukoplakia (HP:0002745)2.10605470
70Acute encephalopathy (HP:0006846)2.10454143
71Abnormality of the musculature of the pelvis (HP:0001469)2.10401146
72Abnormality of the hip-girdle musculature (HP:0001445)2.10401146
73Abnormality of the umbilical cord (HP:0010881)2.09561648
74Rough bone trabeculation (HP:0100670)2.08968988
75Intrahepatic cholestasis (HP:0001406)2.08669441
76Abnormality of the vasculature of the conjunctiva (HP:0008054)2.08634605
77Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.08287176
78Metaphyseal dysplasia (HP:0100255)2.06501030
79Mutism (HP:0002300)2.06353422
80Hypothermia (HP:0002045)2.05945249
81Abnormal lung lobation (HP:0002101)2.05830810
82Congenital primary aphakia (HP:0007707)2.04604181
83Aplasia/Hypoplasia involving the musculature (HP:0001460)2.04375995
84Amniotic constriction ring (HP:0009775)2.04361177
85Abnormality of placental membranes (HP:0011409)2.04361177
86Short tibia (HP:0005736)2.03870415
87Medial flaring of the eyebrow (HP:0010747)2.03852767
88Tetraparesis (HP:0002273)2.02595847
89Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.02311661
90Absent epiphyses (HP:0010577)2.02311661
91Small epiphyses (HP:0010585)2.02158308
92Aplasia/hypoplasia of the uterus (HP:0008684)2.01604434
93Microglossia (HP:0000171)2.01030387
94Abnormal umbilical cord blood vessels (HP:0011403)2.00940237
95Single umbilical artery (HP:0001195)2.00940237
96Abnormality of the fetal cardiovascular system (HP:0010948)2.00940237
97Delayed gross motor development (HP:0002194)2.00005253
98Neoplasm of the peripheral nervous system (HP:0100007)1.99971220
99Metaphyseal irregularity (HP:0003025)1.98877653
100Reduced antithrombin III activity (HP:0001976)1.98406008
101Aplasia/Hypoplasia of the tongue (HP:0010295)1.97667333
102Methylmalonic acidemia (HP:0002912)1.96226295
103Respiratory difficulties (HP:0002880)1.94906393
104Patellar aplasia (HP:0006443)1.94232162
105Recurrent abscess formation (HP:0002722)1.93453641
106Renal cortical cysts (HP:0000803)1.92791969
107Abnormality of renal resorption (HP:0011038)1.92564071
108Aplasia/Hypoplasia of the sacrum (HP:0008517)1.91004341
109Spondylolisthesis (HP:0003302)1.90860109
110Agnosia (HP:0010524)1.89723438
111Hypomagnesemia (HP:0002917)1.88821798
112Increased serum lactate (HP:0002151)1.87297841
113Abnormality of the septum pellucidum (HP:0007375)1.86607287
114Abnormality of the phalanges of the 2nd finger (HP:0009541)1.85648620
115Aplasia/Hypoplasia of the patella (HP:0006498)1.85461138
116Macrocytic anemia (HP:0001972)1.84764409
117Beaking of vertebral bodies (HP:0004568)1.84120432
118Respiratory failure (HP:0002878)1.83220705
119Small intestinal stenosis (HP:0012848)1.83097986
120Duodenal stenosis (HP:0100867)1.83097986
121White forelock (HP:0002211)1.82767418
122Conical tooth (HP:0000698)1.82453583
123Pancytopenia (HP:0001876)1.81570151
124Glossoptosis (HP:0000162)1.80813733
125Aortic dissection (HP:0002647)1.80005824
126Axonal loss (HP:0003447)1.79787253
127Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.79242842
128Abnormal protein N-linked glycosylation (HP:0012347)1.79242842
129Abnormal protein glycosylation (HP:0012346)1.79242842
130Abnormal glycosylation (HP:0012345)1.79242842
131Absent septum pellucidum (HP:0001331)1.77951180
132Gait imbalance (HP:0002141)1.77371350
133Abnormality of the labia minora (HP:0012880)1.77344425
134Hyperglycinemia (HP:0002154)1.75670516
135Cerebral edema (HP:0002181)1.74383039
136Vascular tortuosity (HP:0004948)1.73972851
137Osteolytic defects of the hand bones (HP:0009699)1.73730533
138Osteolytic defects of the phalanges of the hand (HP:0009771)1.73730533
139Colon cancer (HP:0003003)1.72972104
140Ankle contracture (HP:0006466)1.72603427
141Hypoplasia of the uterus (HP:0000013)1.72453928
142Stomach cancer (HP:0012126)1.72303101
143Abnormalities of placenta or umbilical cord (HP:0001194)1.71725524
144Hypoglycemic coma (HP:0001325)1.71606238
145Anhidrosis (HP:0000970)1.71291458
146Abnormality of macrophages (HP:0004311)1.70896996
147Arterial tortuosity (HP:0005116)1.70769558
148Pancreatic fibrosis (HP:0100732)1.69979712
149Aplasia of the musculature (HP:0100854)1.69382801
150Nephrogenic diabetes insipidus (HP:0009806)1.67545573
151Neuroendocrine neoplasm (HP:0100634)1.67454986
152Proximal tubulopathy (HP:0000114)1.67441551
153Peripheral hypomyelination (HP:0007182)1.67024719
154Reticulocytopenia (HP:0001896)1.66127612
155IgG deficiency (HP:0004315)1.65954441
156Autoimmune thrombocytopenia (HP:0001973)1.64648088
157Genital tract atresia (HP:0001827)1.64304957
158Poor head control (HP:0002421)1.64045605
159Sensory axonal neuropathy (HP:0003390)1.63094329
160Generalized aminoaciduria (HP:0002909)1.62927458
161True hermaphroditism (HP:0010459)1.62823918
162Cutaneous melanoma (HP:0012056)1.62644364
163Conjunctival telangiectasia (HP:0000524)1.62292979
164Rectal fistula (HP:0100590)1.61416319
165Rectovaginal fistula (HP:0000143)1.61416319
166Nuclear cataract (HP:0100018)1.61261918
167Follicular hyperkeratosis (HP:0007502)1.60620815
168Systemic lupus erythematosus (HP:0002725)1.60278140
169Prostate neoplasm (HP:0100787)1.57616885
170Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.57259975
171Decreased activity of mitochondrial respiratory chain (HP:0008972)1.57259975
172Short clavicles (HP:0000894)1.57167351
173Soft skin (HP:0000977)1.56684560
174Shoulder girdle muscle weakness (HP:0003547)1.54966868

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.66406740
2STK393.53556496
3TRIM283.37998613
4PBK3.19345529
5MKNK12.68635129
6BCR2.67564313
7OXSR12.55093154
8MST42.55075795
9STK162.53928766
10EIF2AK12.47943740
11LIMK12.34130785
12LATS12.22423304
13NEK12.12611818
14TESK22.10294619
15PLK42.09529864
16EIF2AK32.05655568
17WEE12.05526045
18EPHB22.03153739
19MAPKAPK51.98069334
20SRPK11.79889747
21CSNK1G31.73337176
22VRK11.62666891
23NEK61.58651203
24TSSK61.57762967
25STK241.57208959
26ACVR1B1.55452908
27BMPR1B1.48483256
28TAOK31.43821078
29BRSK21.39692847
30NME21.36435880
31DYRK21.35378892
32CSNK1A1L1.33691405
33ILK1.30512084
34STK31.29972332
35WNK41.28462552
36IRAK41.27671603
37PLK31.26591997
38CSNK1G11.24127049
39EPHB11.23829267
40RPS6KA41.22812647
41NUAK11.20698534
42DDR21.19472357
43EIF2AK21.18061705
44ERBB41.15933151
45MKNK21.11122298
46CLK11.06684830
47PIM21.06271073
48ERBB31.03688299
49MET1.03309321
50BLK1.03207293
51WNK31.00406250
52VRK20.97471716
53RPS6KA50.97454340
54ARAF0.96421119
55SIK30.94690689
56KSR10.92870787
57CCNB10.92209014
58CDC70.92148341
59TAF10.90955747
60TXK0.89704029
61PLK10.85108551
62PKN10.84778882
63CSNK1G20.84721570
64GRK70.83723703
65PDGFRA0.83405486
66EPHA20.83151898
67ZAK0.80869732
68TNIK0.80092577
69PASK0.78671582
70PNCK0.78183561
71AURKA0.76538496
72TESK10.73334456
73ABL20.72206746
74DMPK0.70708829
75YES10.70701489
76PRKCE0.70089849
77TRPM70.68934280
78ADRBK20.68888547
79PINK10.68867461
80TLK10.68186505
81TIE10.68098167
82MAP2K70.67523005
83MELK0.67210399
84TGFBR20.66901639
85TYK20.66453543
86PAK10.66266104
87TGFBR10.65100208
88AKT30.64035929
89CDK190.63081276
90PAK30.61952998
91IKBKB0.61644907
92PLK20.60674098
93TTK0.60325711
94FGR0.59789454
95STK38L0.58706458
96BMPR20.58635635
97AURKB0.58543473
98STK100.58306343
99STK40.56688098
100NEK90.56295387
101ROCK20.56039131
102MAP2K20.54216900
103CSNK2A10.53772924
104BRSK10.52378542
105FGFR10.49688042
106BCKDK0.49148115
107NLK0.48945926
108JAK10.47750795
109CAMKK20.47603811
110MINK10.47323454
111ADRBK10.46621024
112RPS6KB20.45205340
113TEC0.45191315
114KDR0.45169459
115NME10.44894455
116IRAK10.44471468
117MAP3K50.44244120
118PDK20.44093374
119CHEK20.44042975
120MAP3K30.43710113
121CSNK2A20.42945770
122LYN0.42647083
123MAP3K120.42577023
124CDK140.42430060
125MAP3K140.42324320
126MYLK0.42104292
127FLT30.40401930
128EGFR0.39663767
129CDK80.39371724
130MOS0.39168967
131MAPK130.37653520
132MUSK0.37206006
133CAMK2B0.36556515
134MAPKAPK20.36524355
135PAK40.35272880
136LCK0.35217762
137CDK70.33684425
138ROCK10.33444523
139WNK10.32811802
140DYRK30.32339830

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.31928274
2RNA polymerase_Homo sapiens_hsa030203.64251926
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.40171262
4Protein export_Homo sapiens_hsa030603.01211793
5Ribosome_Homo sapiens_hsa030102.91952816
6Steroid biosynthesis_Homo sapiens_hsa001002.42044650
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.38440696
8Oxidative phosphorylation_Homo sapiens_hsa001902.38354199
9Mismatch repair_Homo sapiens_hsa034302.26213767
10Sulfur metabolism_Homo sapiens_hsa009202.25018528
11Basal transcription factors_Homo sapiens_hsa030222.20633830
12DNA replication_Homo sapiens_hsa030302.18066378
13Spliceosome_Homo sapiens_hsa030402.15913198
14Parkinsons disease_Homo sapiens_hsa050122.02214363
15Homologous recombination_Homo sapiens_hsa034401.94052937
16Nucleotide excision repair_Homo sapiens_hsa034201.89366073
17Fatty acid elongation_Homo sapiens_hsa000621.85194210
18Propanoate metabolism_Homo sapiens_hsa006401.83194083
19Pyrimidine metabolism_Homo sapiens_hsa002401.80792915
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.79717582
21RNA transport_Homo sapiens_hsa030131.73043482
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.67814645
23Non-homologous end-joining_Homo sapiens_hsa034501.64425248
24Ether lipid metabolism_Homo sapiens_hsa005651.62340004
25Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.58993927
26Huntingtons disease_Homo sapiens_hsa050161.51860738
27Cell cycle_Homo sapiens_hsa041101.49934351
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47882629
29Base excision repair_Homo sapiens_hsa034101.39156900
30SNARE interactions in vesicular transport_Homo sapiens_hsa041301.36010901
31Alzheimers disease_Homo sapiens_hsa050101.28421576
32Arachidonic acid metabolism_Homo sapiens_hsa005901.25942078
33RNA degradation_Homo sapiens_hsa030181.17872760
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.15034960
35Sphingolipid metabolism_Homo sapiens_hsa006001.13609825
36Rheumatoid arthritis_Homo sapiens_hsa053231.13450456
37Epstein-Barr virus infection_Homo sapiens_hsa051691.13257977
38Purine metabolism_Homo sapiens_hsa002301.13179799
39Vitamin B6 metabolism_Homo sapiens_hsa007501.07496422
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.05854320
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.00821354
42Phagosome_Homo sapiens_hsa041450.95561649
43Autoimmune thyroid disease_Homo sapiens_hsa053200.93934276
44Glutathione metabolism_Homo sapiens_hsa004800.93174465
45Allograft rejection_Homo sapiens_hsa053300.93051834
46Collecting duct acid secretion_Homo sapiens_hsa049660.91651174
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90610232
48Complement and coagulation cascades_Homo sapiens_hsa046100.90122865
49Fanconi anemia pathway_Homo sapiens_hsa034600.89822858
50Regulation of autophagy_Homo sapiens_hsa041400.88942517
51Linoleic acid metabolism_Homo sapiens_hsa005910.88690509
52Graft-versus-host disease_Homo sapiens_hsa053320.86340482
53Vibrio cholerae infection_Homo sapiens_hsa051100.83822604
54Shigellosis_Homo sapiens_hsa051310.83349498
55Lysosome_Homo sapiens_hsa041420.82323148
56Pyruvate metabolism_Homo sapiens_hsa006200.80058703
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78874329
58Adherens junction_Homo sapiens_hsa045200.78449998
59Malaria_Homo sapiens_hsa051440.75086617
60Legionellosis_Homo sapiens_hsa051340.74562760
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72377601
62Antigen processing and presentation_Homo sapiens_hsa046120.71720989
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71379140
64Staphylococcus aureus infection_Homo sapiens_hsa051500.70646355
65Asthma_Homo sapiens_hsa053100.70036291
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.69665182
67p53 signaling pathway_Homo sapiens_hsa041150.69518466
68mRNA surveillance pathway_Homo sapiens_hsa030150.68543648
69NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66978182
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66529427
71Hedgehog signaling pathway_Homo sapiens_hsa043400.66196848
72One carbon pool by folate_Homo sapiens_hsa006700.65964278
73Proteoglycans in cancer_Homo sapiens_hsa052050.64658446
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61985594
75Pertussis_Homo sapiens_hsa051330.60743044
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.60661655
77Folate biosynthesis_Homo sapiens_hsa007900.60475684
78Other glycan degradation_Homo sapiens_hsa005110.60356478
79Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59994880
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.59604090
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59031315
82Hippo signaling pathway_Homo sapiens_hsa043900.58768986
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58660581
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58083512
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56700074
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54564336
87Hematopoietic cell lineage_Homo sapiens_hsa046400.51971095
88Systemic lupus erythematosus_Homo sapiens_hsa053220.51520459
89Viral carcinogenesis_Homo sapiens_hsa052030.50873208
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50850372
91Salmonella infection_Homo sapiens_hsa051320.50459992
92Primary immunodeficiency_Homo sapiens_hsa053400.49119033
93Tight junction_Homo sapiens_hsa045300.46348726
94Galactose metabolism_Homo sapiens_hsa000520.45299314
95Metabolic pathways_Homo sapiens_hsa011000.43664712
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43659482
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.42166343
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41900040
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41760111
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.41029364
101Herpes simplex infection_Homo sapiens_hsa051680.40988338
102Viral myocarditis_Homo sapiens_hsa054160.40789190
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.39647491
104Small cell lung cancer_Homo sapiens_hsa052220.39182781
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39080077
106Cysteine and methionine metabolism_Homo sapiens_hsa002700.38189535
107African trypanosomiasis_Homo sapiens_hsa051430.35573755
108Leishmaniasis_Homo sapiens_hsa051400.35440619
109Toll-like receptor signaling pathway_Homo sapiens_hsa046200.34964299
110Basal cell carcinoma_Homo sapiens_hsa052170.34935890
111Vitamin digestion and absorption_Homo sapiens_hsa049770.34640028
112Arginine and proline metabolism_Homo sapiens_hsa003300.34634398
113TGF-beta signaling pathway_Homo sapiens_hsa043500.34285172
1142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.33479708
115Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32227242
116Measles_Homo sapiens_hsa051620.31953571
117N-Glycan biosynthesis_Homo sapiens_hsa005100.31645658
118Mineral absorption_Homo sapiens_hsa049780.31355620
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30626032
120Oocyte meiosis_Homo sapiens_hsa041140.30303560
121Focal adhesion_Homo sapiens_hsa045100.30086830
122Tuberculosis_Homo sapiens_hsa051520.29120087
123Pathways in cancer_Homo sapiens_hsa052000.28914963
124* Endocytosis_Homo sapiens_hsa041440.28097925
125Pentose phosphate pathway_Homo sapiens_hsa000300.27990235
126ECM-receptor interaction_Homo sapiens_hsa045120.26981260
127Apoptosis_Homo sapiens_hsa042100.26934422
128PI3K-Akt signaling pathway_Homo sapiens_hsa041510.26134058
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26080884
130Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.23037729
131Renin-angiotensin system_Homo sapiens_hsa046140.22557160
132Axon guidance_Homo sapiens_hsa043600.20130102
133RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.20044872
134Alcoholism_Homo sapiens_hsa050340.19899583

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »