ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA double-strand break processing (GO:0000729)	6.12091580
2	chromatin remodeling at centromere (GO:0031055)	5.26916833
3	replication fork processing (GO:0031297)	5.21088561
4	CENP-A containing nucleosome assembly (GO:0034080)	5.11096148
5	regulation of centriole replication (GO:0046599)	5.00503743
6	regulation of cilium movement (GO:0003352)	4.60418238
7	kinetochore assembly (GO:0051382)	4.50493068
8	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	4.49711998
9	negative regulation of DNA-dependent DNA replication (GO:2000104)	4.43760192
10	kinetochore organization (GO:0051383)	4.41029507
11	DNA replication-independent nucleosome organization (GO:0034724)	4.37745524
12	DNA replication-independent nucleosome assembly (GO:0006336)	4.37745524
13	histone exchange (GO:0043486)	4.20315601
14	metaphase plate congression (GO:0051310)	4.19634395
15	DNA replication-dependent nucleosome assembly (GO:0006335)	4.02815865
16	DNA replication-dependent nucleosome organization (GO:0034723)	4.02815865
17	DNA strand renaturation (GO:0000733)	4.01149070
18	protein K6-linked ubiquitination (GO:0085020)	3.93871550
19	centriole replication (GO:0007099)	3.91818235
20	DNA catabolic process, exonucleolytic (GO:0000738)	3.75529392
21	nucleotide-excision repair, DNA gap filling (GO:0006297)	3.74963791
22	mitotic sister chromatid segregation (GO:0000070)	3.71024073
23	somite development (GO:0061053)	3.70639576
24	limb bud formation (GO:0060174)	3.70507971
25	DNA ligation (GO:0006266)	3.68780408
26	recombinational repair (GO:0000725)	3.68342097
27	DNA strand elongation involved in DNA replication (GO:0006271)	3.65265341
28	double-strand break repair via homologous recombination (GO:0000724)	3.65250456
29	attachment of spindle microtubules to kinetochore (GO:0008608)	3.62706852
30	sister chromatid segregation (GO:0000819)	3.60849382
31	telomere maintenance via semi-conservative replication (GO:0032201)	3.55297810
32	non-recombinational repair (GO:0000726)	3.51928942
33	double-strand break repair via nonhomologous end joining (GO:0006303)	3.51928942
34	negative regulation of DNA recombination (GO:0045910)	3.51463896
35	mitotic recombination (GO:0006312)	3.46772349
36	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.46689239
37	regulation of helicase activity (GO:0051095)	3.43605198
38	synapsis (GO:0007129)	3.41361045
39	postreplication repair (GO:0006301)	3.36477937
40	DNA strand elongation (GO:0022616)	3.35739100
41	resolution of meiotic recombination intermediates (GO:0000712)	3.34025389
42	telomere maintenance via recombination (GO:0000722)	3.32214747
43	translesion synthesis (GO:0019985)	3.28066732
44	establishment of chromosome localization (GO:0051303)	3.26834487
45	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.26009224
46	DNA replication checkpoint (GO:0000076)	3.24705895
47	mitotic metaphase plate congression (GO:0007080)	3.23622138
48	spindle checkpoint (GO:0031577)	3.23486478
49	protein localization to kinetochore (GO:0034501)	3.21173089
50	proteasome assembly (GO:0043248)	3.21159840
51	establishment of integrated proviral latency (GO:0075713)	3.17423870
52	mitotic spindle checkpoint (GO:0071174)	3.16833070
53	hindbrain development (GO:0030902)	3.15411782
54	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.14618042
55	regulation of mitotic spindle checkpoint (GO:1903504)	3.14618042
56	regulation of collateral sprouting (GO:0048670)	3.08078885
57	viral mRNA export from host cell nucleus (GO:0046784)	3.05993456
58	cilium morphogenesis (GO:0060271)	3.05288549
59	mitotic G2/M transition checkpoint (GO:0044818)	3.04673252
60	cullin deneddylation (GO:0010388)	3.04397543
61	response to X-ray (GO:0010165)	3.04090249
62	regulation of centrosome duplication (GO:0010824)	3.04010230
63	regulation of centrosome cycle (GO:0046605)	3.01496199
64	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	2.94539247
65	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	2.94539247
66	negative regulation of mitotic sister chromatid segregation (GO:0033048)	2.94539247
67	negative regulation of mitotic sister chromatid separation (GO:2000816)	2.94539247
68	negative regulation of sister chromatid segregation (GO:0033046)	2.94539247
69	centrosome organization (GO:0051297)	2.93695696
70	striatum development (GO:0021756)	2.92826734
71	regulation of DNA endoreduplication (GO:0032875)	2.89862018
72	olfactory bulb development (GO:0021772)	2.89418456
73	mitotic sister chromatid cohesion (GO:0007064)	2.89079600
74	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.87488297
75	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.87488297
76	mitotic spindle assembly checkpoint (GO:0007094)	2.87105079
77	negative regulation of chromosome segregation (GO:0051985)	2.85875480
78	spindle assembly checkpoint (GO:0071173)	2.83882427
79	microtubule depolymerization (GO:0007019)	2.83276328
80	reciprocal meiotic recombination (GO:0007131)	2.81689927
81	reciprocal DNA recombination (GO:0035825)	2.81689927
82	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	2.79418457
83	regulation of mitotic sister chromatid segregation (GO:0033047)	2.76149289
84	regulation of sister chromatid segregation (GO:0033045)	2.76149289
85	regulation of mitotic sister chromatid separation (GO:0010965)	2.76149289
86	microtubule organizing center organization (GO:0031023)	2.75879679
87	telomere maintenance via telomere lengthening (GO:0010833)	2.75357057
88	regulation of metaphase/anaphase transition of cell cycle (GO:1902099)	2.75231531
89	regulation of mitotic metaphase/anaphase transition (GO:0030071)	2.75231531
90	DNA recombination (GO:0006310)	2.73040727
91	respiratory chain complex IV assembly (GO:0008535)	2.72634001
92	double-strand break repair (GO:0006302)	2.72525836
93	microtubule anchoring (GO:0034453)	2.69391861
94	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.69032970
95	establishment of viral latency (GO:0019043)	2.68575405
96	protein deneddylation (GO:0000338)	2.67802824
97	neural tube formation (GO:0001841)	2.67542517
98	cerebral cortex radially oriented cell migration (GO:0021799)	2.67321291
99	DNA unwinding involved in DNA replication (GO:0006268)	2.66714483
100	protein neddylation (GO:0045116)	2.64139645

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	5.77510252
2	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.54694755
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.20049958
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.02524225
5	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.97869361
6	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.92017905
7	FUS_26573619_Chip-Seq_HEK293_Human	2.65759884
8	VDR_22108803_ChIP-Seq_LS180_Human	2.56289052
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.56073338
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.41747340
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.34018775
12	EWS_26573619_Chip-Seq_HEK293_Human	2.31397295
13	GBX2_23144817_ChIP-Seq_PC3_Human	2.24690190
14	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.23488643
15	IGF1R_20145208_ChIP-Seq_DFB_Human	2.23056050
16	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.07110023
17	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.03216828
18	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.02934229
19	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.00240218
20	P300_19829295_ChIP-Seq_ESCs_Human	1.99686706
21	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.91657739
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.88521626
23	ELK1_19687146_ChIP-ChIP_HELA_Human	1.86598544
24	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.80906814
25	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.76543386
26	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.75453997
27	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.75014224
28	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.74348000
29	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.64727975
30	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.60956987
31	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.60755635
32	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.60556589
33	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.57230974
34	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.53608091
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.52953158
36	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.51786988
37	AR_21909140_ChIP-Seq_LNCAP_Human	1.49966992
38	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.48176471
39	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.46524332
40	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.45126697
41	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.44972150
42	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.42291756
43	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.42254155
44	VDR_23849224_ChIP-Seq_CD4+_Human	1.40821110
45	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.40644854
46	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.39059394
47	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.38968098
48	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.38161911
49	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.36117534
50	SMAD4_21799915_ChIP-Seq_A2780_Human	1.32479241
51	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.32376960
52	ER_23166858_ChIP-Seq_MCF-7_Human	1.32252484
53	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.31655407
54	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.30561158
55	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.29550272
56	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.28767359
57	IRF1_19129219_ChIP-ChIP_H3396_Human	1.27369942
58	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.25563024
59	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.24640513
60	CBP_20019798_ChIP-Seq_JUKART_Human	1.23713914
61	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.23713914
62	AR_25329375_ChIP-Seq_VCAP_Human	1.23233151
63	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.21327081
64	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.20814003
65	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.19155170
66	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.19045645
67	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.18571361
68	NANOG_19829295_ChIP-Seq_ESCs_Human	1.17848656
69	SOX2_19829295_ChIP-Seq_ESCs_Human	1.17848656
70	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.17060459
71	TP53_22573176_ChIP-Seq_HFKS_Human	1.16643675
72	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.16405719
73	BCAT_22108803_ChIP-Seq_LS180_Human	1.15058437
74	TCF4_22108803_ChIP-Seq_LS180_Human	1.13926266
75	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.13464078
76	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.13322742
77	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.09585591
78	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.09478743
79	FOXP3_21729870_ChIP-Seq_TREG_Human	1.09200654
80	TCF4_23295773_ChIP-Seq_U87_Human	1.08512240
81	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.08251831
82	STAT3_23295773_ChIP-Seq_U87_Human	1.08000743
83	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.06991944
84	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.06545130
85	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.06439201
86	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.06325480
87	RUNX2_22187159_ChIP-Seq_PCA_Human	1.05585374
88	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.05087403
89	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.04570914
90	P300_18555785_Chip-Seq_ESCs_Mouse	1.03668140
91	P53_22387025_ChIP-Seq_ESCs_Mouse	1.03441721
92	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.99874686
93	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.99527320
94	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.98759581
95	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.96397888
96	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.95297712
97	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.94106499
98	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.93535742
99	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.92063040
100	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.92062041

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010094_abnormal_chromosome_stability	3.99578847
2	MP0008057_abnormal_DNA_replication	3.29045865
3	MP0003880_abnormal_central_pattern	3.18414927
4	MP0008058_abnormal_DNA_repair	2.97550729
5	MP0001529_abnormal_vocalization	2.40423762
6	MP0003693_abnormal_embryo_hatching	2.34161211
7	MP0002736_abnormal_nociception_after	2.29316935
8	MP0008877_abnormal_DNA_methylation	2.23822880
9	MP0003111_abnormal_nucleus_morphology	2.21184044
10	MP0004957_abnormal_blastocyst_morpholog	2.20401669
11	MP0001984_abnormal_olfaction	2.16217399
12	MP0002234_abnormal_pharynx_morphology	2.13718223
13	MP0008789_abnormal_olfactory_epithelium	2.07324335
14	MP0003937_abnormal_limbs/digits/tail_de	2.07300578
15	MP0006072_abnormal_retinal_apoptosis	1.95957154
16	MP0002751_abnormal_autonomic_nervous	1.95052997
17	MP0005551_abnormal_eye_electrophysiolog	1.89553684
18	MP0005367_renal/urinary_system_phenotyp	1.89487216
19	MP0000516_abnormal_urinary_system	1.89487216
20	MP0002233_abnormal_nose_morphology	1.85928355
21	MP0003121_genomic_imprinting	1.85419923
22	MP0001293_anophthalmia	1.83974884
23	MP0003718_maternal_effect	1.81054031
24	MP0002282_abnormal_trachea_morphology	1.74825148
25	MP0001986_abnormal_taste_sensitivity	1.71543587
26	MP0002102_abnormal_ear_morphology	1.71065910
27	MP0003119_abnormal_digestive_system	1.69444670
28	MP0001968_abnormal_touch/_nociception	1.68934882
29	MP0000538_abnormal_urinary_bladder	1.67905556
30	MP0005360_urolithiasis	1.62138459
31	MP0005499_abnormal_olfactory_system	1.59791104
32	MP0005394_taste/olfaction_phenotype	1.59791104
33	MP0003786_premature_aging	1.58727232
34	MP0008932_abnormal_embryonic_tissue	1.55980111
35	MP0004133_heterotaxia	1.55183177
36	MP0003077_abnormal_cell_cycle	1.54862955
37	MP0000647_abnormal_sebaceous_gland	1.48920559
38	MP0002938_white_spotting	1.46079457
39	MP0003787_abnormal_imprinting	1.40809712
40	MP0005253_abnormal_eye_physiology	1.38382649
41	MP0010030_abnormal_orbit_morphology	1.34968322
42	MP0002653_abnormal_ependyma_morphology	1.33050790
43	MP0001177_atelectasis	1.30257699
44	MP0004043_abnormal_pH_regulation	1.26561904
45	MP0006292_abnormal_olfactory_placode	1.26469879
46	MP0008007_abnormal_cellular_replicative	1.25265842
47	MP0002928_abnormal_bile_duct	1.24550627
48	MP0002254_reproductive_system_inflammat	1.21844774
49	MP0000778_abnormal_nervous_system	1.20274006
50	MP0000383_abnormal_hair_follicle	1.19256515
51	MP0003646_muscle_fatigue	1.16728029
52	MP0003890_abnormal_embryonic-extraembry	1.14967064
53	MP0001286_abnormal_eye_development	1.14835206
54	MP0002734_abnormal_mechanical_nocicepti	1.10978509
55	MP0009697_abnormal_copulation	1.10134217
56	MP0006276_abnormal_autonomic_nervous	1.09430192
57	MP0004145_abnormal_muscle_electrophysio	1.08590094
58	MP0001299_abnormal_eye_distance/	1.07613627
59	MP0003122_maternal_imprinting	1.07459373
60	MP0009703_decreased_birth_body	1.06018073
61	MP0000631_abnormal_neuroendocrine_gland	1.05238595
62	MP0005248_abnormal_Harderian_gland	1.04200924
63	MP0001119_abnormal_female_reproductive	1.03953808
64	MP0002210_abnormal_sex_determination	1.03263175
65	MP0001324_abnormal_eye_pigmentation	1.02550142
66	MP0003195_calcinosis	1.00613396
67	MP0010678_abnormal_skin_adnexa	0.99774407
68	MP0000427_abnormal_hair_cycle	0.97490930
69	MP0001929_abnormal_gametogenesis	0.97213140
70	MP0003755_abnormal_palate_morphology	0.96922993
71	MP0001764_abnormal_homeostasis	0.96021746
72	MP0003123_paternal_imprinting	0.95066525
73	MP0001485_abnormal_pinna_reflex	0.94359768
74	MP0000569_abnormal_digit_pigmentation	0.93817528
75	MP0009672_abnormal_birth_weight	0.93760578
76	MP0004270_analgesia	0.92357636
77	MP0004197_abnormal_fetal_growth/weight/	0.91278740
78	MP0000372_irregular_coat_pigmentation	0.89965747
79	MP0000613_abnormal_salivary_gland	0.89100760
80	MP0005187_abnormal_penis_morphology	0.87734057
81	MP0002111_abnormal_tail_morphology	0.87328967
82	MP0005391_vision/eye_phenotype	0.87126202
83	MP0003137_abnormal_impulse_conducting	0.86952561
84	MP0000653_abnormal_sex_gland	0.84675663
85	MP0005084_abnormal_gallbladder_morpholo	0.83053373
86	MP0003567_abnormal_fetal_cardiomyocyte	0.81074685
87	MP0010386_abnormal_urinary_bladder	0.81040697
88	MP0004215_abnormal_myocardial_fiber	0.80726772
89	MP0002177_abnormal_outer_ear	0.80683705
90	MP0000639_abnormal_adrenal_gland	0.79831798
91	MP0001905_abnormal_dopamine_level	0.79530150
92	MP0003861_abnormal_nervous_system	0.79064891
93	MP0002138_abnormal_hepatobiliary_system	0.78656635
94	MP0005195_abnormal_posterior_eye	0.78630660
95	MP0008995_early_reproductive_senescence	0.76698417
96	MP0002697_abnormal_eye_size	0.76040236
97	MP0002752_abnormal_somatic_nervous	0.75633218
98	MP0001145_abnormal_male_reproductive	0.74948884
99	MP0003698_abnormal_male_reproductive	0.74874116
100	MP0005266_abnormal_metabolism	0.73360136

Predicted human phenotypes

Rank	Gene Set	Z-score
1	True hermaphroditism (HP:0010459)	4.46112185
2	Pancreatic cysts (HP:0001737)	4.23072137
3	Abnormality of chromosome stability (HP:0003220)	4.18541171
4	Chromsome breakage (HP:0040012)	3.94692436
5	Volvulus (HP:0002580)	3.89437417
6	Abnormality of midbrain morphology (HP:0002418)	3.88641261
7	Molar tooth sign on MRI (HP:0002419)	3.88641261
8	Pancreatic fibrosis (HP:0100732)	3.86832035
9	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.84910386
10	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.64487278
11	Meckel diverticulum (HP:0002245)	3.56463082
12	Intestinal atresia (HP:0011100)	3.48538692
13	Abnormality of the ileum (HP:0001549)	3.42903354
14	Chronic hepatic failure (HP:0100626)	3.42393779
15	Aplasia/Hypoplasia of the tongue (HP:0010295)	3.16039626
16	Abnormal biliary tract physiology (HP:0012439)	3.14148648
17	Bile duct proliferation (HP:0001408)	3.14148648
18	Nephronophthisis (HP:0000090)	3.13591887
19	Abnormality of the preputium (HP:0100587)	3.13180972
20	Bifid tongue (HP:0010297)	3.04639521
21	Abnormality of the duodenum (HP:0002246)	3.02448497
22	Colon cancer (HP:0003003)	3.00025209
23	Progressive inability to walk (HP:0002505)	2.98405032
24	Duodenal stenosis (HP:0100867)	2.92504274
25	Small intestinal stenosis (HP:0012848)	2.92504274
26	Abnormality of the labia minora (HP:0012880)	2.82616804
27	Cystic liver disease (HP:0006706)	2.81624611
28	Anencephaly (HP:0002323)	2.71516031
29	Methylmalonic acidemia (HP:0002912)	2.68923739
30	Aqueductal stenosis (HP:0002410)	2.62052105
31	Renal cortical cysts (HP:0000803)	2.60256937
32	Occipital encephalocele (HP:0002085)	2.58414115
33	Triphalangeal thumb (HP:0001199)	2.58308379
34	Abnormality of the renal medulla (HP:0100957)	2.54317230
35	Clubbing of toes (HP:0100760)	2.53823509
36	Medial flaring of the eyebrow (HP:0010747)	2.52856073
37	Congenital primary aphakia (HP:0007707)	2.52850852
38	Sclerocornea (HP:0000647)	2.49899471
39	Sloping forehead (HP:0000340)	2.48934540
40	Preaxial hand polydactyly (HP:0001177)	2.46998511
41	Postaxial foot polydactyly (HP:0001830)	2.44181419
42	Gait imbalance (HP:0002141)	2.43571987
43	Thyroid-stimulating hormone excess (HP:0002925)	2.41010960
44	Abnormal umbilical cord blood vessels (HP:0011403)	2.36203425
45	Single umbilical artery (HP:0001195)	2.36203425
46	Abnormality of the fetal cardiovascular system (HP:0010948)	2.36203425
47	Abnormal lung lobation (HP:0002101)	2.33689971
48	Vaginal atresia (HP:0000148)	2.31939088
49	Narrow forehead (HP:0000341)	2.28669219
50	Supernumerary spleens (HP:0009799)	2.28633330
51	Oligodactyly (hands) (HP:0001180)	2.26470633
52	Genital tract atresia (HP:0001827)	2.25167028
53	Abnormality of the renal cortex (HP:0011035)	2.21983902
54	Nephrogenic diabetes insipidus (HP:0009806)	2.18835298
55	Male pseudohermaphroditism (HP:0000037)	2.12810276
56	Anophthalmia (HP:0000528)	2.12648858
57	Oculomotor apraxia (HP:0000657)	2.10163290
58	Oligohydramnios (HP:0001562)	2.09882946
59	Dandy-Walker malformation (HP:0001305)	2.07191802
60	Astigmatism (HP:0000483)	2.06019719
61	Abnormality of alanine metabolism (HP:0010916)	2.03212545
62	Hyperalaninemia (HP:0003348)	2.03212545
63	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.03212545
64	Absent radius (HP:0003974)	2.02959887
65	Small hand (HP:0200055)	2.02601493
66	Inability to walk (HP:0002540)	2.01661745
67	Disproportionate short-trunk short stature (HP:0003521)	1.99946077
68	Ectopic kidney (HP:0000086)	1.97080498
69	Nephroblastoma (Wilms tumor) (HP:0002667)	1.95794568
70	Embryonal renal neoplasm (HP:0011794)	1.95449442
71	Multiple enchondromatosis (HP:0005701)	1.94403925
72	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.93766829
73	Congenital hepatic fibrosis (HP:0002612)	1.92865373
74	Medulloblastoma (HP:0002885)	1.92437217
75	Renal hypoplasia (HP:0000089)	1.92159469
76	Hyperglycinemia (HP:0002154)	1.92005186
77	Methylmalonic aciduria (HP:0012120)	1.91896353
78	Aganglionic megacolon (HP:0002251)	1.89888362
79	Absent forearm bone (HP:0003953)	1.89562741
80	Aplasia involving forearm bones (HP:0009822)	1.89562741
81	Abnormality of the carotid arteries (HP:0005344)	1.89382549
82	Postaxial hand polydactyly (HP:0001162)	1.86423882
83	Horseshoe kidney (HP:0000085)	1.84724586
84	Cerebellar dysplasia (HP:0007033)	1.83117982
85	Chorioretinal coloboma (HP:0000567)	1.81672312
86	Abnormality of the parathyroid morphology (HP:0011766)	1.81350627
87	Intrahepatic cholestasis (HP:0001406)	1.80419673
88	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.79829526
89	Neoplasm of the adrenal cortex (HP:0100641)	1.78012936
90	Hypoplastic pelvis (HP:0008839)	1.77180428
91	Increased CSF lactate (HP:0002490)	1.76503324
92	Choanal atresia (HP:0000453)	1.76237339
93	Myelodysplasia (HP:0002863)	1.75541484
94	Neoplasm of the oral cavity (HP:0100649)	1.72635960
95	Abnormality of methionine metabolism (HP:0010901)	1.72335345
96	Median cleft lip (HP:0000161)	1.71499514
97	Gonadotropin excess (HP:0000837)	1.70352814
98	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.68805815
99	Broad foot (HP:0001769)	1.67958013
100	Asplenia (HP:0001746)	1.64887224

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TNIK	3.57881122
2	NEK1	3.56924820
3	BMPR1B	3.04624036
4	BUB1	2.93660131
5	PLK4	2.93529742
6	EPHA4	2.90067296
7	TRIM28	2.81890873
8	FRK	2.63818571
9	WEE1	2.35625037
10	ACVR1B	2.31951103
11	ZAK	2.30172306
12	WNK3	2.29955882
13	BRSK2	2.25550961
14	PLK3	2.25342101
15	ERBB4	2.22437238
16	PBK	2.21626383
17	TAF1	2.14676874
18	PDK2	2.10564787
19	VRK2	2.05575608
20	PNCK	2.02623788
21	NUAK1	2.01243119
22	MKNK2	1.95490392
23	CDC7	1.94616220
24	MKNK1	1.80989842
25	MAP4K2	1.69057338
26	EIF2AK3	1.68970716
27	VRK1	1.67701655
28	MAPK13	1.63926109
29	TTK	1.46543950
30	TSSK6	1.41321178
31	TGFBR1	1.41312615
32	MST4	1.35038946
33	PLK2	1.34695828
34	GRK1	1.22710954
35	CASK	1.19165588
36	PLK1	1.19035860
37	CCNB1	1.17866442
38	EIF2AK2	1.12589273
39	CHEK2	1.07727940
40	ATR	1.07323019
41	SRPK1	1.06204784
42	CSNK1G3	0.93211724
43	NEK2	0.92368438
44	MARK1	0.91033906
45	CSNK1G1	0.90126123
46	CSNK1A1L	0.86316953
47	CSNK1G2	0.85490488
48	DYRK3	0.84578642
49	BRSK1	0.79459155
50	BCR	0.77125083
51	FLT3	0.76411572
52	ERBB3	0.76261427
53	FGFR2	0.71589742
54	DAPK1	0.67543653
55	MAP3K4	0.67457546
56	MAPKAPK5	0.67215042
57	ATM	0.65161792
58	CDK8	0.64937676
59	AURKB	0.60611473
60	PASK	0.59223766
61	INSRR	0.58750206
62	CDK3	0.56157345
63	DYRK2	0.53371191
64	PKN2	0.53287104
65	PRKCG	0.53198457
66	PKN1	0.53085915
67	MARK3	0.52438263
68	ADRBK2	0.52153436
69	CHEK1	0.50400672
70	BRD4	0.47888015
71	CDK18	0.45798741
72	FGFR1	0.45700030
73	CDK7	0.44452965
74	CSNK1A1	0.42250690
75	EIF2AK1	0.42223513
76	CDK15	0.40841286
77	MELK	0.40301169
78	PRKCE	0.38989300
79	FGR	0.38345924
80	TNK2	0.35380059
81	CSNK1D	0.34069106
82	CDK11A	0.33802164
83	CDK14	0.33090858
84	MINK1	0.33055299
85	UHMK1	0.31943085
86	CDK1	0.30007482
87	STK38L	0.29529103
88	AKT3	0.28813654
89	PAK3	0.28590470
90	STK16	0.27393852
91	PRKDC	0.27123257
92	OXSR1	0.26975041
93	GRK5	0.25839001
94	CSNK2A1	0.25190758
95	PRKACB	0.24212535
96	LIMK1	0.23981279
97	ADRBK1	0.20452074
98	PTK2B	0.20267046
99	CSNK1E	0.20056276
100	OBSCN	0.19868003

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fanconi anemia pathway_Homo sapiens_hsa03460	3.96645688
2	Non-homologous end-joining_Homo sapiens_hsa03450	3.91328746
3	Mismatch repair_Homo sapiens_hsa03430	3.55822747
4	Homologous recombination_Homo sapiens_hsa03440	3.37689311
5	DNA replication_Homo sapiens_hsa03030	3.33436415
6	Propanoate metabolism_Homo sapiens_hsa00640	2.98387691
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.76524776
8	Protein export_Homo sapiens_hsa03060	2.76506051
9	Steroid biosynthesis_Homo sapiens_hsa00100	2.72836315
10	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.11260569
11	Proteasome_Homo sapiens_hsa03050	2.11106918
12	Nucleotide excision repair_Homo sapiens_hsa03420	1.97201542
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.93316741
14	RNA polymerase_Homo sapiens_hsa03020	1.93051214
15	Base excision repair_Homo sapiens_hsa03410	1.91502449
16	Butanoate metabolism_Homo sapiens_hsa00650	1.89242879
17	Cell cycle_Homo sapiens_hsa04110	1.80480441
18	RNA degradation_Homo sapiens_hsa03018	1.74127553
19	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.72487951
20	RNA transport_Homo sapiens_hsa03013	1.63987700
21	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.63452660
22	Basal transcription factors_Homo sapiens_hsa03022	1.63064144
23	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.56988580
24	Caffeine metabolism_Homo sapiens_hsa00232	1.52069703
25	Glutathione metabolism_Homo sapiens_hsa00480	1.42731843
26	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.41710288
27	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.40667144
28	Fatty acid elongation_Homo sapiens_hsa00062	1.30739979
29	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.30449815
30	Phototransduction_Homo sapiens_hsa04744	1.27018501
31	Pyrimidine metabolism_Homo sapiens_hsa00240	1.25080507
32	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.25031527
33	Pyruvate metabolism_Homo sapiens_hsa00620	1.23727974
34	One carbon pool by folate_Homo sapiens_hsa00670	1.19625811
35	Spliceosome_Homo sapiens_hsa03040	1.19541196
36	Purine metabolism_Homo sapiens_hsa00230	1.19211795
37	Tryptophan metabolism_Homo sapiens_hsa00380	1.11110987
38	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.06249654
39	Oocyte meiosis_Homo sapiens_hsa04114	1.05001248
40	Folate biosynthesis_Homo sapiens_hsa00790	1.04977132
41	Parkinsons disease_Homo sapiens_hsa05012	1.00471076
42	Oxidative phosphorylation_Homo sapiens_hsa00190	0.98850572
43	p53 signaling pathway_Homo sapiens_hsa04115	0.97784196
44	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.96966058
45	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.93845030
46	beta-Alanine metabolism_Homo sapiens_hsa00410	0.92986343
47	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.85836795
48	Fatty acid metabolism_Homo sapiens_hsa01212	0.85218920
49	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.85054393
50	Fatty acid degradation_Homo sapiens_hsa00071	0.78852218
51	mRNA surveillance pathway_Homo sapiens_hsa03015	0.78440294
52	Chemical carcinogenesis_Homo sapiens_hsa05204	0.77798716
53	Huntingtons disease_Homo sapiens_hsa05016	0.76883075
54	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.75530306
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.75419185
56	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.74095566
57	Linoleic acid metabolism_Homo sapiens_hsa00591	0.73725028
58	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.66446243
59	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.65518578
60	Basal cell carcinoma_Homo sapiens_hsa05217	0.63747384
61	Ether lipid metabolism_Homo sapiens_hsa00565	0.63668963
62	Peroxisome_Homo sapiens_hsa04146	0.63437232
63	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.63205472
64	Selenocompound metabolism_Homo sapiens_hsa00450	0.60677735
65	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.60439107
66	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.58803348
67	Carbon metabolism_Homo sapiens_hsa01200	0.57949661
68	Metabolic pathways_Homo sapiens_hsa01100	0.57083727
69	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.56923618
70	Taste transduction_Homo sapiens_hsa04742	0.55434090
71	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.54810575
72	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.54036985
73	Fat digestion and absorption_Homo sapiens_hsa04975	0.53765555
74	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.52746431
75	Olfactory transduction_Homo sapiens_hsa04740	0.51867550
76	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.50435486
77	Lysine degradation_Homo sapiens_hsa00310	0.48083047
78	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.47294663
79	Nicotine addiction_Homo sapiens_hsa05033	0.43572736
80	Tight junction_Homo sapiens_hsa04530	0.41530902
81	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.37841589
82	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.36906075
83	Regulation of autophagy_Homo sapiens_hsa04140	0.36503681
84	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.36337729
85	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.35725513
86	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.35488069
87	Alzheimers disease_Homo sapiens_hsa05010	0.35461142
88	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.35146540
89	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.34910354
90	Retinol metabolism_Homo sapiens_hsa00830	0.30308606
91	Hippo signaling pathway_Homo sapiens_hsa04390	0.27428428
92	Nitrogen metabolism_Homo sapiens_hsa00910	0.26255656
93	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.25266080
94	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.22395291
95	Wnt signaling pathway_Homo sapiens_hsa04310	0.21833292
96	Dopaminergic synapse_Homo sapiens_hsa04728	0.20865601
97	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.18952638
98	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.15168173
99	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.15138903
100	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.12938903

SNX6P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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