SNX7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region like some family members, and its exact function is unknown. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1facial nerve structural organization (GO:0021612)4.74879174
2phospholipid scrambling (GO:0017121)4.35535846
3respiratory chain complex IV assembly (GO:0008535)4.29455996
4DNA deamination (GO:0045006)4.12366170
5GDP-mannose metabolic process (GO:0019673)4.10297452
6pattern specification involved in kidney development (GO:0061004)4.01033856
7protein heterotetramerization (GO:0051290)3.92779977
8platelet dense granule organization (GO:0060155)3.92435098
9regulation of metalloenzyme activity (GO:0048552)3.88899839
10regulation of pigment cell differentiation (GO:0050932)3.84458779
11response to interferon-alpha (GO:0035455)3.83067806
12regulation of apoptotic process involved in morphogenesis (GO:1902337)3.80187636
13mannosylation (GO:0097502)3.80000766
14dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.68983805
15cytochrome complex assembly (GO:0017004)3.60544327
16signal peptide processing (GO:0006465)3.60241324
17nephron tubule formation (GO:0072079)3.51487131
18paraxial mesoderm development (GO:0048339)3.46883620
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.46511624
20negative regulation of metanephros development (GO:0072217)3.44327864
21proteasome assembly (GO:0043248)3.43796740
22positive regulation of cellular amine metabolic process (GO:0033240)3.42149835
23regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.38451492
24chondrocyte proliferation (GO:0035988)3.36320808
25endosome to melanosome transport (GO:0035646)3.31539926
26endosome to pigment granule transport (GO:0043485)3.31539926
27mature B cell differentiation involved in immune response (GO:0002313)3.29398446
28regulation of type B pancreatic cell apoptotic process (GO:2000674)3.26491274
29ventricular cardiac muscle cell development (GO:0055015)3.24136917
30mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.22062529
31cranial nerve structural organization (GO:0021604)3.20687712
32regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.18156531
33cranial nerve morphogenesis (GO:0021602)3.17493771
34establishment of integrated proviral latency (GO:0075713)3.13962268
35cell adhesion mediated by integrin (GO:0033627)3.12830196
36peripheral nervous system neuron development (GO:0048935)3.12334665
37omega-hydroxylase P450 pathway (GO:0097267)3.11973364
38regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.10205576
39positive regulation of macrophage differentiation (GO:0045651)3.08528095
40metanephric nephron tubule development (GO:0072234)3.07399928
41metanephric tubule development (GO:0072170)3.07399928
42lymphoid progenitor cell differentiation (GO:0002320)3.07309522
43membrane invagination (GO:0010324)3.07087039
44androgen biosynthetic process (GO:0006702)3.04241688
45mesonephros development (GO:0001823)3.03090582
46negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.01617493
47C-terminal protein lipidation (GO:0006501)2.96939745
48notochord development (GO:0030903)2.93790234
49negative regulation of transcription by competitive promoter binding (GO:0010944)2.91011592
50postsynaptic membrane organization (GO:0001941)2.90208567
51response to interferon-beta (GO:0035456)2.90085425
52hemidesmosome assembly (GO:0031581)2.89749259
53adenosine metabolic process (GO:0046085)2.87405456
54negative regulation of chondrocyte differentiation (GO:0032331)2.86521124
55phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.85517526
56negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.83673728
57regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.79035426
58positive regulation of glycoprotein biosynthetic process (GO:0010560)2.77769952
59neurofilament cytoskeleton organization (GO:0060052)2.77022956
60negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.74569736
61negative regulation of keratinocyte proliferation (GO:0010839)2.74451839
62GPI anchor biosynthetic process (GO:0006506)2.73510712
63regulation of cardioblast differentiation (GO:0051890)2.71893548
64endothelial cell morphogenesis (GO:0001886)2.71517504
65collagen fibril organization (GO:0030199)2.71213831
66neuron projection extension involved in neuron projection guidance (GO:1902284)2.69843075
67axon extension involved in axon guidance (GO:0048846)2.69843075
68regulation of transforming growth factor beta2 production (GO:0032909)2.67743576
69sequestering of extracellular ligand from receptor (GO:0035581)2.65735175
70regulation of interleukin-8 secretion (GO:2000482)2.65644441
71metanephric nephron epithelium development (GO:0072243)2.65179038
72sympathetic nervous system development (GO:0048485)2.64853288
73generation of neurons (GO:0048699)2.64774190
74embryonic foregut morphogenesis (GO:0048617)2.64239224
75neutrophil activation involved in immune response (GO:0002283)2.62532964
76metanephric epithelium development (GO:0072207)2.62320492
77mesenchymal-epithelial cell signaling (GO:0060638)2.61785683
78response to folic acid (GO:0051593)2.61625967
79response to increased oxygen levels (GO:0036296)2.61409743
80response to hyperoxia (GO:0055093)2.61409743
81urogenital system development (GO:0001655)2.59405740
82retina vasculature morphogenesis in camera-type eye (GO:0061299)2.58618875
83positive regulation of protein export from nucleus (GO:0046827)2.58189243
84mitotic metaphase plate congression (GO:0007080)2.57202022
85cell migration involved in sprouting angiogenesis (GO:0002042)2.55754704
86anterior/posterior axis specification, embryo (GO:0008595)2.55581114
87aminoglycoside antibiotic metabolic process (GO:0030647)2.51966819
88regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.51922031
89cellular response to vitamin D (GO:0071305)2.51388347
90negative regulation of nitric oxide biosynthetic process (GO:0045019)2.51275715
91nephron epithelium development (GO:0072009)2.50401015
92gap junction assembly (GO:0016264)2.50233515
93activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.50108418
94superoxide anion generation (GO:0042554)2.50035314
95ribosomal small subunit assembly (GO:0000028)2.49391831
96positive regulation of metanephros development (GO:0072216)2.49171712
97endodermal cell differentiation (GO:0035987)2.48449573
98C-terminal protein amino acid modification (GO:0018410)2.45128172
99mitochondrial calcium ion transport (GO:0006851)2.44700203
100viral genome replication (GO:0019079)2.44166189
101positive regulation of T cell mediated cytotoxicity (GO:0001916)2.43932272
102artery development (GO:0060840)2.43580106
103protein localization to kinetochore (GO:0034501)2.42237300
104metaphase plate congression (GO:0051310)2.42228960
105phagocytosis, engulfment (GO:0006911)2.42193609
106cellular response to ATP (GO:0071318)2.42043878
107nucleotide-sugar biosynthetic process (GO:0009226)2.41946292
108nucleotide-sugar metabolic process (GO:0009225)2.40900349
109deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.40440368
110positive regulation of endothelial cell apoptotic process (GO:2000353)2.40046379
111UDP-N-acetylglucosamine metabolic process (GO:0006047)2.39714004
112ribosome assembly (GO:0042255)2.39450798
113negative regulation of fibroblast apoptotic process (GO:2000270)2.39299545
114regulation of mesenchymal cell apoptotic process (GO:2001053)2.38390952
115mature B cell differentiation (GO:0002335)2.37938320
116response to peptidoglycan (GO:0032494)2.37934565
117regulation of protein heterodimerization activity (GO:0043497)2.37531313
118regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.36481327
119negative regulation of granulocyte differentiation (GO:0030853)2.36275426
120positive regulation of protein autophosphorylation (GO:0031954)2.36142942
121negative regulation of homotypic cell-cell adhesion (GO:0034111)2.36063305
122endothelium development (GO:0003158)2.35959660
123nucleoside diphosphate catabolic process (GO:0009134)2.35727155
124skin morphogenesis (GO:0043589)2.35470426
125COPII vesicle coating (GO:0048208)2.35460223
126lymphangiogenesis (GO:0001946)2.35394226
127desmosome organization (GO:0002934)2.34936413
128establishment of viral latency (GO:0019043)2.34828676
129Golgi transport vesicle coating (GO:0048200)2.34654520
130COPI coating of Golgi vesicle (GO:0048205)2.34654520
131hippo signaling (GO:0035329)2.34485641
132kidney mesenchyme development (GO:0072074)2.33473290
133behavioral response to pain (GO:0048266)2.33031841
134ganglion development (GO:0061548)2.31721327
135negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.31425898
136CENP-A containing nucleosome assembly (GO:0034080)2.31204191
137Arp2/3 complex-mediated actin nucleation (GO:0034314)2.30938939
138lipopolysaccharide biosynthetic process (GO:0009103)2.30384579
139negative regulation of axon extension involved in axon guidance (GO:0048843)2.30198485
140L-fucose catabolic process (GO:0042355)2.29435091
141fucose catabolic process (GO:0019317)2.29435091
142L-fucose metabolic process (GO:0042354)2.29435091
143cytokine production involved in immune response (GO:0002367)2.29141283
144daunorubicin metabolic process (GO:0044597)2.28968043
145doxorubicin metabolic process (GO:0044598)2.28968043
146peptidyl-proline hydroxylation (GO:0019511)2.28121860
147chromatin remodeling at centromere (GO:0031055)2.28049448
148regulation of keratinocyte proliferation (GO:0010837)2.27577253
149cellular response to vitamin (GO:0071295)2.26339611
150negative regulation of stem cell proliferation (GO:2000647)2.25993844
151positive regulation of actin filament depolymerization (GO:0030836)2.25713959
152negative regulation of axon guidance (GO:1902668)2.24744788
153response to X-ray (GO:0010165)2.24660357
154regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.23178368
155type B pancreatic cell proliferation (GO:0044342)2.23165833
156mitotic cytokinesis (GO:0000281)2.21775461
157negative chemotaxis (GO:0050919)2.20246105
158regulation of mitotic spindle organization (GO:0060236)2.18930283
159muscle cell migration (GO:0014812)2.14393930
160membrane assembly (GO:0071709)2.13878889
161outer ear morphogenesis (GO:0042473)2.13291187
162response to redox state (GO:0051775)2.12830960
163wound healing, spreading of epidermal cells (GO:0035313)2.12484480
164regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.11290112
165maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.10822438
166protein localization to cell surface (GO:0034394)2.10671015
167dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.10629400
168protein heterotrimerization (GO:0070208)2.10601588
169dorsal/ventral axis specification (GO:0009950)2.10474547
170protein retention in ER lumen (GO:0006621)2.06411667
171midgut development (GO:0007494)2.05275703
172substrate-dependent cell migration (GO:0006929)2.03818090
173female gonad development (GO:0008585)2.03101851
174embryonic cranial skeleton morphogenesis (GO:0048701)2.02838524
175metanephric mesenchyme development (GO:0072075)2.02723188
176substrate adhesion-dependent cell spreading (GO:0034446)2.02499292
177protein hydroxylation (GO:0018126)2.02168536
178protein maturation by protein folding (GO:0022417)2.01433711
179mitotic sister chromatid segregation (GO:0000070)2.01247203
180craniofacial suture morphogenesis (GO:0097094)2.00851409
181establishment of chromosome localization (GO:0051303)2.00408149
182bundle of His cell to Purkinje myocyte communication (GO:0086069)1.99250499
183regulation of spindle organization (GO:0090224)1.98279651
184bone trabecula formation (GO:0060346)1.97793054
185regulation of axon guidance (GO:1902667)1.96641828
186membrane budding (GO:0006900)1.96602587
187establishment of planar polarity (GO:0001736)1.96299132
188establishment of tissue polarity (GO:0007164)1.96299132
189regulation of axon extension involved in axon guidance (GO:0048841)1.96166986
190regulation of cell fate specification (GO:0042659)1.96013977
191keratinocyte proliferation (GO:0043616)1.94925802
192spindle checkpoint (GO:0031577)1.94883435
193regulation of heart morphogenesis (GO:2000826)1.94323410
194histone exchange (GO:0043486)1.94055377

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.64920966
2AR_21909140_ChIP-Seq_LNCAP_Human3.12335117
3SALL1_21062744_ChIP-ChIP_HESCs_Human2.87369850
4CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.72685730
5ELF1_17652178_ChIP-ChIP_JURKAT_Human2.72137259
6LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.67526345
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.64874229
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.59350993
9NOTCH1_21737748_ChIP-Seq_TLL_Human2.49052400
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.47877054
11IGF1R_20145208_ChIP-Seq_DFB_Human2.47799087
12EZH2_22144423_ChIP-Seq_EOC_Human2.40585381
13E2F7_22180533_ChIP-Seq_HELA_Human2.35427033
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.31641715
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.21230809
16NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.14785128
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.11419354
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.08538163
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.06720266
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.02834068
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.02767512
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.02676034
23EGR1_23403033_ChIP-Seq_LIVER_Mouse1.99593410
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.96842891
25BRD4_25478319_ChIP-Seq_HGPS_Human1.96029645
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.94085354
27* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.90506894
28SRF_21415370_ChIP-Seq_HL-1_Mouse1.87189318
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.79701046
30GATA1_22025678_ChIP-Seq_K562_Human1.78866175
31BP1_19119308_ChIP-ChIP_Hs578T_Human1.78072290
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.76508228
33PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.74645163
34* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71106660
35KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.71045286
36PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.70480257
37POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.66358965
38E2F4_17652178_ChIP-ChIP_JURKAT_Human1.66154057
39EP300_21415370_ChIP-Seq_HL-1_Mouse1.63855877
40GABP_17652178_ChIP-ChIP_JURKAT_Human1.62889449
41KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.62661236
42GBX2_23144817_ChIP-Seq_PC3_Human1.61698378
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.60601204
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.60421741
45FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.59904124
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.58930129
47FUS_26573619_Chip-Seq_HEK293_Human1.57954696
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57641713
49SOX2_20726797_ChIP-Seq_SW620_Human1.57293705
50MYC_18555785_ChIP-Seq_MESCs_Mouse1.56672615
51SUZ12_27294783_Chip-Seq_NPCs_Mouse1.56539031
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54218165
53STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.53135835
54HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.52788732
55SALL4_18804426_ChIP-ChIP_XEN_Mouse1.52659892
56ERG_20887958_ChIP-Seq_HPC-7_Mouse1.51152505
57TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.51026590
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50438602
59E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.49684219
60NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.48832548
61HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.48327486
62LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.47848526
63TP63_17297297_ChIP-ChIP_HaCaT_Human1.47308755
64SOX17_20123909_ChIP-Seq_XEN_Mouse1.46182362
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.45906179
66NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.44680642
67NRF2_20460467_ChIP-Seq_MEFs_Mouse1.44680642
68WT1_19549856_ChIP-ChIP_CCG9911_Human1.43356964
69SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.42879555
70RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.41392371
71GATA2_21666600_ChIP-Seq_HMVEC_Human1.40991180
72STAT4_19710469_ChIP-ChIP_TH1__Mouse1.40347193
73* TP53_18474530_ChIP-ChIP_U2OS_Human1.39229286
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.39146738
75Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.39141048
76HIF1A_21447827_ChIP-Seq_MCF-7_Human1.38740088
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38489995
78SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37576489
79NANOG_16153702_ChIP-ChIP_HESCs_Human1.36918414
80* EWS_26573619_Chip-Seq_HEK293_Human1.36070533
81ZFP57_27257070_Chip-Seq_ESCs_Mouse1.35808109
82CREB1_15753290_ChIP-ChIP_HEK293T_Human1.34249340
83CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.34246547
84PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32593759
85CJUN_26792858_Chip-Seq_BT549_Human1.32531957
86* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.31361242
87* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.31361242
88SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.30701508
89CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.30658255
90CLOCK_20551151_ChIP-Seq_293T_Human1.28809647
91ELK1_22589737_ChIP-Seq_MCF10A_Human1.27819979
92TCF3_18692474_ChIP-Seq_MEFs_Mouse1.26602062
93ELK1_19687146_ChIP-ChIP_HELA_Human1.26465991
94ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26319611
95CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.25739608
96JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.25609940
97SCL_19346495_ChIP-Seq_HPC-7_Human1.25565326
98P53_22387025_ChIP-Seq_ESCs_Mouse1.25347655
99NMYC_18555785_Chip-Seq_ESCs_Mouse1.24004392
100SPI1_23547873_ChIP-Seq_NB4_Human1.23132977
101* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22755978
102* STAT3_18555785_Chip-Seq_ESCs_Mouse1.20849983
103TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20523491
104PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20432853
105POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19178725
106NELFA_20434984_ChIP-Seq_ESCs_Mouse1.19058121
107GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18986247
108P300_19829295_ChIP-Seq_ESCs_Human1.18798140
109AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18629509
110EOMES_21245162_ChIP-Seq_HESCs_Human1.17389290
111* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16628309
112E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16060039
113HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.15903308
114* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15279836
115PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15041748
116* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.14765528
117HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14253968
118MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.13604271
119NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13370143
120HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12830385
121POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12023488
122IRF8_27001747_Chip-Seq_BMDM_Mouse1.11383045
123RUNX1_27457419_Chip-Seq_LIVER_Mouse1.11364480
124* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11011385
125SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.10937239
126AR_20517297_ChIP-Seq_VCAP_Human1.10480309
127TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09925781
128EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.09774635
129EGR1_19032775_ChIP-ChIP_M12_Human1.09491210
130TAL1_26923725_Chip-Seq_HPCs_Mouse1.09221216
131MYCN_18555785_ChIP-Seq_MESCs_Mouse1.08056536
132ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07746808
133PPAR_26484153_Chip-Seq_NCI-H1993_Human1.07594349
134SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06762257
135EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06679882
136CRX_20693478_ChIP-Seq_RETINA_Mouse1.06401896
137CDX2_20551321_ChIP-Seq_CACO-2_Human1.06337202
138E2F1_18555785_Chip-Seq_ESCs_Mouse1.05526433
139RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04903510
140P300_18555785_Chip-Seq_ESCs_Mouse1.04686880
141STAT1_17558387_ChIP-Seq_HELA_Human1.04655559
142KDM2B_26808549_Chip-Seq_REH_Human1.04459632
143MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.03626373
144MYC_19030024_ChIP-ChIP_MESCs_Mouse1.03488488
145PU1_27457419_Chip-Seq_LIVER_Mouse1.02666179
146EED_16625203_ChIP-ChIP_MESCs_Mouse1.01323806
147* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01269906
148* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01023436
149ZFX_18555785_ChIP-Seq_MESCs_Mouse1.01007133
150SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.00946671
151OCT4_18555785_Chip-Seq_ESCs_Mouse1.00632876
152SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00325613
153NFI_21473784_ChIP-Seq_ESCs_Mouse0.99945833
154SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99120997
155GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.99102304
156TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98819357
157PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98730744
158MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.98287309
159TBX3_20139965_ChIP-Seq_MESCs_Mouse0.97954230
160TP53_16413492_ChIP-PET_HCT116_Human0.95231697
161NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.95126762
162ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94976883
163ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.94613069
164SMAD3_21741376_ChIP-Seq_EPCs_Human0.92906612
165ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.88418260
166TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88306955
167NANOG_18555785_ChIP-Seq_MESCs_Mouse0.86607725
168STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.86029210
169SOX2_18555785_ChIP-Seq_MESCs_Mouse0.85451491
170MYC_19079543_ChIP-ChIP_MESCs_Mouse0.85265460
171* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.84840014
172TCF3_18692474_ChIP-Seq_MESCs_Mouse0.84078352
173SMAD4_21799915_ChIP-Seq_A2780_Human0.83932765
174* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.82703234

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.19231103
2MP0001188_hyperpigmentation3.71419674
3MP0001986_abnormal_taste_sensitivity3.50195230
4MP0003941_abnormal_skin_development3.31114069
5MP0003724_increased_susceptibility_to3.08158781
6MP0008438_abnormal_cutaneous_collagen2.91824149
7MP0005174_abnormal_tail_pigmentation2.90910329
8MP0000015_abnormal_ear_pigmentation2.79846227
9MP0003705_abnormal_hypodermis_morpholog2.67915928
10MP0000372_irregular_coat_pigmentation2.66107722
11MP0010030_abnormal_orbit_morphology2.55583773
12MP0010368_abnormal_lymphatic_system2.41818963
13MP0005623_abnormal_meninges_morphology2.38185480
14MP0005409_darkened_coat_color2.36218082
15MP0002876_abnormal_thyroid_physiology2.32140432
16MP0002735_abnormal_chemical_nociception2.27346377
17MP0010352_gastrointestinal_tract_polyps2.26362320
18MP0005503_abnormal_tendon_morphology2.14020967
19MP0001958_emphysema2.07029836
20MP0009785_altered_susceptibility_to2.05396758
21MP0000681_abnormal_thyroid_gland2.04899871
22MP0003566_abnormal_cell_adhesion2.01904267
23MP0009697_abnormal_copulation1.99692965
24MP0005075_abnormal_melanosome_morpholog1.97562836
25MP0003950_abnormal_plasma_membrane1.97288573
26MP0005275_abnormal_skin_tensile1.90420108
27MP0000762_abnormal_tongue_morphology1.90182695
28MP0001968_abnormal_touch/_nociception1.87914800
29MP0002148_abnormal_hypersensitivity_rea1.85329435
30MP0008260_abnormal_autophagy1.84262031
31MP0005084_abnormal_gallbladder_morpholo1.83137892
32MP0001542_abnormal_bone_strength1.82628867
33MP0004381_abnormal_hair_follicle1.79658890
34MP0000537_abnormal_urethra_morphology1.78509127
35MP0001299_abnormal_eye_distance/1.78502990
36MP0001348_abnormal_lacrimal_gland1.76258473
37MP0003937_abnormal_limbs/digits/tail_de1.76093650
38MP0009053_abnormal_anal_canal1.75197815
39MP0002736_abnormal_nociception_after1.71622943
40MP0003136_yellow_coat_color1.70402026
41MP0000490_abnormal_crypts_of1.68483950
42MP0001835_abnormal_antigen_presentation1.64034743
43MP0003283_abnormal_digestive_organ1.61258284
44MP0003436_decreased_susceptibility_to1.57736326
45MP0009780_abnormal_chondrocyte_physiolo1.57296043
46MP0008932_abnormal_embryonic_tissue1.56048245
47MP0003279_aneurysm1.55280000
48MP0004782_abnormal_surfactant_physiolog1.54513304
49MP0002233_abnormal_nose_morphology1.54074606
50MP0010234_abnormal_vibrissa_follicle1.53835497
51MP0003806_abnormal_nucleotide_metabolis1.53147408
52MP0001879_abnormal_lymphatic_vessel1.49292197
53MP0002095_abnormal_skin_pigmentation1.46987194
54MP0004957_abnormal_blastocyst_morpholog1.46910705
55MP0003868_abnormal_feces_composition1.45132488
56MP0006054_spinal_hemorrhage1.44633040
57MP0003755_abnormal_palate_morphology1.42878188
58MP0009384_cardiac_valve_regurgitation1.42225993
59MP0002697_abnormal_eye_size1.40246896
60MP0003385_abnormal_body_wall1.38124644
61MP0002139_abnormal_hepatobiliary_system1.37637445
62MP0002751_abnormal_autonomic_nervous1.36586759
63MP0006276_abnormal_autonomic_nervous1.35532191
64MP0008004_abnormal_stomach_pH1.34371239
65MP0002177_abnormal_outer_ear1.31686751
66MP0005025_abnormal_response_to1.30969985
67MP0000516_abnormal_urinary_system1.30622643
68MP0005367_renal/urinary_system_phenotyp1.30622643
69MP0005171_absent_coat_pigmentation1.29834255
70MP0000534_abnormal_ureter_morphology1.29208530
71MP0004147_increased_porphyrin_level1.28769954
72MP0002419_abnormal_innate_immunity1.28183283
73MP0006292_abnormal_olfactory_placode1.28138748
74MP0005023_abnormal_wound_healing1.27361149
75MP0001293_anophthalmia1.27188957
76MP0002234_abnormal_pharynx_morphology1.26984277
77MP0004272_abnormal_basement_membrane1.23413878
78MP0003119_abnormal_digestive_system1.23367386
79MP0005257_abnormal_intraocular_pressure1.23050021
80MP0009764_decreased_sensitivity_to1.22312034
81MP0000428_abnormal_craniofacial_morphol1.21846819
82MP0003890_abnormal_embryonic-extraembry1.19412452
83MP0000566_synostosis1.18653611
84MP0003935_abnormal_craniofacial_develop1.16795425
85MP0001533_abnormal_skeleton_physiology1.16623508
86MP0003186_abnormal_redox_activity1.15384772
87MP0005408_hypopigmentation1.15301064
88MP0002998_abnormal_bone_remodeling1.14331473
89MP0000462_abnormal_digestive_system1.14212296
90MP0002396_abnormal_hematopoietic_system1.13526796
91MP0000467_abnormal_esophagus_morphology1.13333667
92MP0002084_abnormal_developmental_patter1.13223569
93MP0000751_myopathy1.12494328
94MP0005464_abnormal_platelet_physiology1.12433701
95MP0001853_heart_inflammation1.12382343
96MP0003693_abnormal_embryo_hatching1.12220462
97MP0005508_abnormal_skeleton_morphology1.10513618
98MP0003942_abnormal_urinary_system1.10026519
99MP0002282_abnormal_trachea_morphology1.09571801
100MP0000749_muscle_degeneration1.09247059
101MP0000767_abnormal_smooth_muscle1.08357928
102MP0005000_abnormal_immune_tolerance1.06972017
103MP0002896_abnormal_bone_mineralization1.06762536
104MP0002132_abnormal_respiratory_system1.06302616
105MP0002085_abnormal_embryonic_tissue1.05738962
106MP0000432_abnormal_head_morphology1.04475643
107MP0003111_abnormal_nucleus_morphology1.03328476
108MP0000613_abnormal_salivary_gland1.01158238
109MP0010155_abnormal_intestine_physiology1.00989727
110MP0001286_abnormal_eye_development1.00988185
111MP0009333_abnormal_splenocyte_physiolog1.00838382
112MP0002933_joint_inflammation0.99204240
113MP0005197_abnormal_uvea_morphology0.99177054
114MP0005360_urolithiasis0.98821244
115MP0002102_abnormal_ear_morphology0.98618050
116MP0010678_abnormal_skin_adnexa0.96659538
117MP0003077_abnormal_cell_cycle0.96022766
118MP0008007_abnormal_cellular_replicative0.94904763
119MP0001243_abnormal_dermal_layer0.92589855
120MP0005390_skeleton_phenotype0.92246846
121MP0005671_abnormal_response_to0.91032552
122MP0002877_abnormal_melanocyte_morpholog0.90961451
123MP0005187_abnormal_penis_morphology0.89723677
124MP0003011_delayed_dark_adaptation0.89673400
125MP0003879_abnormal_hair_cell0.89250518
126MP0002111_abnormal_tail_morphology0.88690471
127MP0000579_abnormal_nail_morphology0.88218296
128MP0008469_abnormal_protein_level0.87361838
129MP0000465_gastrointestinal_hemorrhage0.86989767
130MP0002108_abnormal_muscle_morphology0.86906306
131MP0010094_abnormal_chromosome_stability0.86395654
132MP0001849_ear_inflammation0.86112730
133MP0002092_abnormal_eye_morphology0.86068925
134MP0000685_abnormal_immune_system0.84094851
135MP0002295_abnormal_pulmonary_circulatio0.83763437
136MP0001845_abnormal_inflammatory_respons0.83613993
137MP0005595_abnormal_vascular_smooth0.83471335
138MP0002938_white_spotting0.83037107
139MP0000049_abnormal_middle_ear0.82945527
140MP0003315_abnormal_perineum_morphology0.82724784
141MP0002932_abnormal_joint_morphology0.82547947
142MP0000647_abnormal_sebaceous_gland0.82361680
143MP0001672_abnormal_embryogenesis/_devel0.82202328
144MP0005380_embryogenesis_phenotype0.82202328
145MP0009250_abnormal_appendicular_skeleto0.81977158
146MP0001730_embryonic_growth_arrest0.81891105
147MP0001270_distended_abdomen0.80957266
148MP0000733_abnormal_muscle_development0.80910587
149MP0002060_abnormal_skin_morphology0.80327724
150MP0002723_abnormal_immune_serum0.80066416
151MP0003718_maternal_effect0.79947363
152MP0000858_altered_metastatic_potential0.78989555
153MP0003091_abnormal_cell_migration0.78183207
154MP0005165_increased_susceptibility_to0.78019500
155MP0001663_abnormal_digestive_system0.77157309
156MP0001186_pigmentation_phenotype0.77122195
157MP0002116_abnormal_craniofacial_bone0.76877161
158MP0003115_abnormal_respiratory_system0.76554959
159MP0000163_abnormal_cartilage_morphology0.76064231
160MP0002166_altered_tumor_susceptibility0.75583754
161MP0005193_abnormal_anterior_eye0.74029910
162MP0010386_abnormal_urinary_bladder0.73864734
163MP0002452_abnormal_antigen_presenting0.73789093
164MP0002006_tumorigenesis0.73751168
165MP0003984_embryonic_growth_retardation0.73562274
166MP0005636_abnormal_mineral_homeostasis0.73328353
167MP0001697_abnormal_embryo_size0.73208969
168MP0002160_abnormal_reproductive_system0.73106021
169MP0002163_abnormal_gland_morphology0.72563369
170MP0002138_abnormal_hepatobiliary_system0.72325109
171MP0000343_altered_response_to0.71971890
172MP0002088_abnormal_embryonic_growth/wei0.71189550
173MP0005501_abnormal_skin_physiology0.70778653
174MP0004019_abnormal_vitamin_homeostasis0.70056299
175MP0003795_abnormal_bone_structure0.70027741
176MP0001915_intracranial_hemorrhage0.69718143
177MP0002405_respiratory_system_inflammati0.69657557
178MP0002109_abnormal_limb_morphology0.69441881
179MP0000678_abnormal_parathyroid_gland0.69394446
180MP0002420_abnormal_adaptive_immunity0.69286448
181MP0002114_abnormal_axial_skeleton0.69233955
182MP0001819_abnormal_immune_cell0.69153178

Predicted human phenotypes

RankGene SetZ-score
1Reduced antithrombin III activity (HP:0001976)7.54805209
2Type I transferrin isoform profile (HP:0003642)6.83908614
3Hypothermia (HP:0002045)5.50460178
4Abnormal protein glycosylation (HP:0012346)5.07006814
5Abnormal glycosylation (HP:0012345)5.07006814
6Abnormal isoelectric focusing of serum transferrin (HP:0003160)5.07006814
7Abnormal protein N-linked glycosylation (HP:0012347)5.07006814
8Abnormality of magnesium homeostasis (HP:0004921)4.09377109
9Thyroid-stimulating hormone excess (HP:0002925)3.80625718
10Prolonged partial thromboplastin time (HP:0003645)3.56370070
11Vascular tortuosity (HP:0004948)3.22313358
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.00641747
13Arterial tortuosity (HP:0005116)3.00367127
14Hypomagnesemia (HP:0002917)2.99766613
15Renal Fanconi syndrome (HP:0001994)2.87824987
16Increased hepatocellular lipid droplets (HP:0006565)2.87783479
17Protrusio acetabuli (HP:0003179)2.83258222
18Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.82697926
19Ulnar claw (HP:0001178)2.80994157
20Follicular hyperkeratosis (HP:0007502)2.79617669
21Premature rupture of membranes (HP:0001788)2.77922231
22Vertebral compression fractures (HP:0002953)2.77760216
23Knee flexion contracture (HP:0006380)2.75602646
24Bradycardia (HP:0001662)2.74627669
25Absent rod-and cone-mediated responses on ERG (HP:0007688)2.70685301
26Ankle contracture (HP:0006466)2.61881326
27Nonprogressive disorder (HP:0003680)2.58769202
28Neonatal short-limb short stature (HP:0008921)2.58479908
29Vacuolated lymphocytes (HP:0001922)2.57632114
30Elevated erythrocyte sedimentation rate (HP:0003565)2.56065668
31Lipid accumulation in hepatocytes (HP:0006561)2.55940100
32Abnormality of the fetal cardiovascular system (HP:0010948)2.51445629
33Abnormal umbilical cord blood vessels (HP:0011403)2.51445629
34Single umbilical artery (HP:0001195)2.51445629
35Coronal craniosynostosis (HP:0004440)2.50459890
36Exertional dyspnea (HP:0002875)2.48667834
37Biconcave vertebral bodies (HP:0004586)2.48465782
38Beaking of vertebral bodies (HP:0004568)2.45346261
39Aortic aneurysm (HP:0004942)2.44112665
40Abnormality of the umbilical cord (HP:0010881)2.43956652
41Abnormality of renal resorption (HP:0011038)2.41846241
42Pterygium (HP:0001059)2.33101937
43Short nail (HP:0001799)2.28754310
44Metaphyseal dysplasia (HP:0100255)2.28109951
45Thoracic kyphosis (HP:0002942)2.27239332
46Shallow orbits (HP:0000586)2.24863381
47Bladder diverticulum (HP:0000015)2.24736199
48Breech presentation (HP:0001623)2.23965242
49Increased intramyocellular lipid droplets (HP:0012240)2.21723397
50Peritonitis (HP:0002586)2.19839108
51Cervical subluxation (HP:0003308)2.17516602
52Atrophic scars (HP:0001075)2.17409912
53Abnormal delivery (HP:0001787)2.15367151
54Abnormality of urine glucose concentration (HP:0011016)2.14971411
55Glycosuria (HP:0003076)2.14971411
56Renal tubular dysfunction (HP:0000124)2.14583282
57Microglossia (HP:0000171)2.13629213
58Severe visual impairment (HP:0001141)2.13391502
59Generalized aminoaciduria (HP:0002909)2.13065526
60Hepatic necrosis (HP:0002605)2.07674814
61Wormian bones (HP:0002645)2.07032582
62Abnormalities of placenta or umbilical cord (HP:0001194)2.06624474
63Spinal rigidity (HP:0003306)2.05637034
64Osteolytic defects of the phalanges of the hand (HP:0009771)2.04600886
65Osteolytic defects of the hand bones (HP:0009699)2.04600886
66Hepatocellular necrosis (HP:0001404)2.04541480
67Abnormal number of erythroid precursors (HP:0012131)2.03427634
68Myositis (HP:0100614)2.03257168
69Increased corneal curvature (HP:0100692)2.02341371
70Keratoconus (HP:0000563)2.02341371
71Cardiovascular calcification (HP:0011915)2.02191469
72Abnormality of cells of the erythroid lineage (HP:0012130)2.01535002
73Petechiae (HP:0000967)1.99880320
74Type 2 muscle fiber atrophy (HP:0003554)1.99041206
75Delayed gross motor development (HP:0002194)1.99034172
76Aplastic anemia (HP:0001915)1.98786572
77Abnormality of the prostate (HP:0008775)1.97974721
78Fragile skin (HP:0001030)1.96997905
79Hypoplastic pelvis (HP:0008839)1.96530747
80Bowel diverticulosis (HP:0005222)1.96232703
81Broad metatarsal (HP:0001783)1.95046543
82Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.89696454
83Decreased activity of mitochondrial respiratory chain (HP:0008972)1.89696454
84Thrombocytosis (HP:0001894)1.88888823
85Increased muscle lipid content (HP:0009058)1.84853959
863-Methylglutaconic aciduria (HP:0003535)1.83823745
87Hyperphosphaturia (HP:0003109)1.83063979
88Patchy hypopigmentation of hair (HP:0011365)1.81214393
89Reticulocytopenia (HP:0001896)1.80696437
90Microvesicular hepatic steatosis (HP:0001414)1.80408371
91Soft skin (HP:0000977)1.80041333
92Right ventricular cardiomyopathy (HP:0011663)1.78236042
93Reduced subcutaneous adipose tissue (HP:0003758)1.78216929
94Respiratory distress (HP:0002098)1.76959075
95Spastic diplegia (HP:0001264)1.75937610
96Abnormality of glutamine family amino acid metabolism (HP:0010902)1.75434708
97Azoospermia (HP:0000027)1.75213133
98Lower limb hyperreflexia (HP:0002395)1.74608837
99Limited hip movement (HP:0008800)1.72192168
100Proximal tubulopathy (HP:0000114)1.72030708
101Anhidrosis (HP:0000970)1.70976146
102Natal tooth (HP:0000695)1.70282370
103Recurrent abscess formation (HP:0002722)1.70204978
104Aplasia/Hypoplasia of the sacrum (HP:0008517)1.69693250
105Cortical visual impairment (HP:0100704)1.69612960
106Muscle fiber atrophy (HP:0100295)1.69565791
107Abnormal urine phosphate concentration (HP:0012599)1.67821055
108Respiratory difficulties (HP:0002880)1.67769365
109Broad face (HP:0000283)1.65655506
110Abnormal rod and cone electroretinograms (HP:0008323)1.65278916
111Aortic dissection (HP:0002647)1.65121345
112Prolonged bleeding time (HP:0003010)1.64940078
113Hypoglycemic seizures (HP:0002173)1.64421393
114Hyperparathyroidism (HP:0000843)1.64385491
115Hyperactive renin-angiotensin system (HP:0000841)1.64087885
116Capillary hemangiomas (HP:0005306)1.62977223
117Bifid tongue (HP:0010297)1.62620837
118Blue sclerae (HP:0000592)1.62500326
119Adrenal hypoplasia (HP:0000835)1.62006439
120Upper limb muscle weakness (HP:0003484)1.61988517
121Episodic fever (HP:0001954)1.61937320
122Abnormality of dentin (HP:0010299)1.60558697
123Intrahepatic cholestasis (HP:0001406)1.60370408
124Hyperphosphatemia (HP:0002905)1.59795759
125Pulmonary fibrosis (HP:0002206)1.58905566
126Septo-optic dysplasia (HP:0100842)1.58516277
127Overgrowth (HP:0001548)1.58492677
128Poor head control (HP:0002421)1.58413802
129Distal lower limb muscle weakness (HP:0009053)1.58353386
130Joint hemorrhage (HP:0005261)1.57599206
131Vascular calcification (HP:0004934)1.56982989
132Interstitial pulmonary disease (HP:0006530)1.56922019
133Spinal cord compression (HP:0002176)1.56206089
134Biliary tract neoplasm (HP:0100574)1.56030490
135Retinal dysplasia (HP:0007973)1.55568728
136Absent frontal sinuses (HP:0002688)1.54410457
137True hermaphroditism (HP:0010459)1.54351801
138Epistaxis (HP:0000421)1.54316824
139Facial cleft (HP:0002006)1.53921598
140Microcytic anemia (HP:0001935)1.53508553
141Segmental peripheral demyelination/remyelination (HP:0003481)1.52104873
142Wrist flexion contracture (HP:0001239)1.52066084
143Limb-girdle muscle weakness (HP:0003325)1.52008891
144Genu recurvatum (HP:0002816)1.51140240
145Spinal canal stenosis (HP:0003416)1.51030026
146Abnormality of the acetabulum (HP:0003170)1.50632257
147Tubulointerstitial nephritis (HP:0001970)1.50344973
148Mitochondrial inheritance (HP:0001427)1.50321443
149Menorrhagia (HP:0000132)1.49253016
150Limb-girdle muscle atrophy (HP:0003797)1.49024182
151Abnormality of methionine metabolism (HP:0010901)1.48404456
152Abnormal biliary tract morphology (HP:0012440)1.47057888
153Joint laxity (HP:0001388)1.46116308
154Vertebral clefting (HP:0008428)1.44537927
155Hyperextensible skin (HP:0000974)1.44397491
156Delayed cranial suture closure (HP:0000270)1.43788190
157Protruding ear (HP:0000411)1.43752139
158Abnormality of carpal bone ossification (HP:0006257)1.43232380
159Popliteal pterygium (HP:0009756)1.42467916
160Mildly elevated creatine phosphokinase (HP:0008180)1.42073687
161Neoplasm of the rectum (HP:0100743)1.41985234
162Abnormality of proline metabolism (HP:0010907)1.40130471
163Hydroxyprolinuria (HP:0003080)1.40130471
164Meckel diverticulum (HP:0002245)1.38937965
165Absent eyelashes (HP:0000561)1.38568675
166Mitral valve prolapse (HP:0001634)1.36733329
167Increased nuchal translucency (HP:0010880)1.36051543
168Slender build (HP:0001533)1.34349033
169Pulmonic stenosis (HP:0001642)1.33896895
170Deviation of the hallux (HP:0010051)1.33516477
171Occipital encephalocele (HP:0002085)1.33491197
172Aplasia/Hypoplasia of the tongue (HP:0010295)1.33289945
173Vertebral hypoplasia (HP:0008417)1.33258306
174Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.33258306
175Aortic regurgitation (HP:0001659)1.33044701
176Symptomatic seizures (HP:0011145)1.32647863
177Dental crowding (HP:0000678)1.31986634
178Myelomeningocele (HP:0002475)1.31623330
179Astrocytoma (HP:0009592)1.31286771
180Abnormality of the astrocytes (HP:0100707)1.31286771
181Hypoglycemic coma (HP:0001325)1.31125095
182Hip contracture (HP:0003273)1.30899526
183Preaxial foot polydactyly (HP:0001841)1.29428849
184Neoplasm of the small intestine (HP:0100833)1.28767629
185Abnormality of the ileum (HP:0001549)1.28218037
186Absent eyebrow (HP:0002223)1.27755129
187Colon cancer (HP:0003003)1.26905264
188Generalized amyotrophy (HP:0003700)1.26542703
189Inguinal hernia (HP:0000023)1.26480963
190Ulnar bowing (HP:0003031)1.26027180

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK7.02959337
2EIF2AK34.45056107
3NME23.24390535
4STK163.15607532
5NLK3.02982843
6MUSK3.02413424
7BUB12.81332584
8CASK2.76813883
9CAMKK22.56788904
10PIM22.32145099
11IRAK32.29350240
12NEK12.15182588
13MKNK22.10931700
14EPHA22.10341224
15EIF2AK22.07065206
16MET2.04554881
17TTK2.00053038
18IRAK41.94481421
19ERBB41.93544904
20PAK41.90374754
21TEC1.89064679
22BCR1.81609588
23PDGFRA1.79852280
24TRIM281.79579072
25PTK21.72071163
26PLK31.70477965
27LATS11.61705820
28KIT1.55502934
29ZAK1.52622447
30LATS21.52322747
31PRKG21.49685989
32MAP3K141.41108858
33MKNK11.38378246
34VRK21.36250697
35MAP2K71.29486382
36YES11.28561444
37TLK11.27657950
38BLK1.24819243
39NTRK11.24249130
40SRPK11.22712904
41MAP3K121.22111548
42TSSK61.21783266
43PLK21.18678028
44STK31.16394008
45CDC71.13839819
46IRAK11.10867594
47PIK3CG1.09695508
48FLT31.09067098
49VRK11.07245274
50PLK11.05863269
51NEK91.02127878
52FES1.01553419
53BMPR1B1.00963262
54TGFBR11.00313539
55MATK0.98964273
56LIMK10.97570770
57ROCK20.97241924
58BRSK10.96421761
59ADRBK20.96179680
60IKBKB0.91636043
61PAK20.90403938
62MELK0.90101718
63FRK0.88053292
64MST40.87933377
65CSNK1A1L0.87314906
66SIK30.86080544
67TAF10.86022713
68WNK30.85874772
69TBK10.85846099
70CSNK1G30.85814496
71FER0.85347552
72IKBKE0.84593563
73IRAK20.83734902
74LMTK20.83177170
75STK390.82954100
76KDR0.82744576
77FGFR10.82379904
78EPHA30.81824974
79ILK0.80564292
80PLK40.80322259
81PNCK0.79441633
82ROCK10.76890624
83INSRR0.76614859
84CAMK10.75960919
85MYLK0.75760466
86TESK10.74164508
87ZAP700.74083648
88CSNK1G20.73751116
89MST1R0.73556628
90TXK0.71823018
91TRPM70.71667607
92BTK0.71074805
93BCKDK0.70720420
94JAK30.69328968
95MAPKAPK30.68934599
96AURKB0.66191892
97TGFBR20.65443569
98ABL20.65230343
99ERBB30.64819063
100NEK20.64649781
101PRPF4B0.64257291
102DMPK0.63395945
103CHEK20.62957943
104MAP3K110.62875530
105PIK3CA0.61750373
106RIPK40.59470719
107TIE10.56266662
108CDK80.55652714
109MAPK40.54392844
110PRKD30.53547811
111NUAK10.53400931
112TTN0.52922063
113MAPK130.52008031
114MOS0.51576962
115MAP2K30.51226136
116MAP2K60.49938762
117PRKD20.49201478
118BRSK20.48993369
119MAPKAPK50.46053279
120LYN0.45674190
121ACVR1B0.45420768
122CDK70.44744068
123TAOK20.43504082
124EIF2AK10.41988343
125STK100.41817914
126WEE10.39879257
127MAP3K10.39499142
128AKT20.38871626
129CDK90.38778994
130PDGFRB0.38727299
131CDK190.38361327
132STK40.37717195
133GSK3A0.37509945
134STK240.37242098
135BMPR20.36998378
136CAMK2D0.35128297
137SYK0.34866460
138AKT30.34559965
139TYK20.34327652
140PRKCD0.33584633
141PIM10.32993665
142ATM0.32706665
143MAP3K80.31766976
144GRK10.31036134
145LCK0.30509247
146CDK180.30236792
147MAP3K30.30234474
148EPHB20.29573443
149CAMKK10.27245760
150PBK0.26573017
151CSF1R0.25372367
152PRKCE0.22759497
153STK38L0.20492417
154ABL10.20409671
155DDR20.20341818
156CSNK1G10.20338613
157DYRK20.20261087
158MAP2K20.20150162

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.42644723
2Ribosome_Homo sapiens_hsa030102.66195194
3N-Glycan biosynthesis_Homo sapiens_hsa005102.48323393
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.44854314
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.38779483
6Other glycan degradation_Homo sapiens_hsa005112.20547943
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.19068034
8Thyroid cancer_Homo sapiens_hsa052162.15283137
9DNA replication_Homo sapiens_hsa030302.14467186
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.09313279
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.04667488
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.04305738
13Vitamin B6 metabolism_Homo sapiens_hsa007502.02970961
14Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.95567640
15Proteasome_Homo sapiens_hsa030501.83397895
16Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.79975055
17Folate biosynthesis_Homo sapiens_hsa007901.72342770
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.67141835
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.65970862
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.65885694
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.63834888
22Sphingolipid metabolism_Homo sapiens_hsa006001.57944252
23Adherens junction_Homo sapiens_hsa045201.54744702
24Vitamin digestion and absorption_Homo sapiens_hsa049771.53593084
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.52907588
26Non-homologous end-joining_Homo sapiens_hsa034501.52576187
27Homologous recombination_Homo sapiens_hsa034401.50759195
28Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.49369707
29Pyrimidine metabolism_Homo sapiens_hsa002401.48447637
30Hippo signaling pathway_Homo sapiens_hsa043901.47499774
31Arachidonic acid metabolism_Homo sapiens_hsa005901.46718971
32Pyruvate metabolism_Homo sapiens_hsa006201.46230289
33Malaria_Homo sapiens_hsa051441.45691092
34TGF-beta signaling pathway_Homo sapiens_hsa043501.44163556
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.41414685
36Renin-angiotensin system_Homo sapiens_hsa046141.41198889
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.40411453
38Propanoate metabolism_Homo sapiens_hsa006401.39755322
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.38098080
40Leishmaniasis_Homo sapiens_hsa051401.36682812
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.36365141
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.36309357
43Glutathione metabolism_Homo sapiens_hsa004801.31962041
44Basal cell carcinoma_Homo sapiens_hsa052171.28118624
45Hematopoietic cell lineage_Homo sapiens_hsa046401.27805541
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.26603843
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.26253110
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26185244
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25966624
50Cell cycle_Homo sapiens_hsa041101.25067904
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.23092475
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.21539497
53Focal adhesion_Homo sapiens_hsa045101.20070824
54Protein digestion and absorption_Homo sapiens_hsa049741.18779245
55Pertussis_Homo sapiens_hsa051331.17395952
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.16995066
57Tight junction_Homo sapiens_hsa045301.16735515
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.14044489
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13016642
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11945128
61Phagosome_Homo sapiens_hsa041451.11502610
62Hedgehog signaling pathway_Homo sapiens_hsa043401.11292468
63NF-kappa B signaling pathway_Homo sapiens_hsa040641.10861292
64RNA transport_Homo sapiens_hsa030131.10153442
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10023194
66Biosynthesis of amino acids_Homo sapiens_hsa012301.09501638
67Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.06955025
68Sulfur metabolism_Homo sapiens_hsa009201.06933857
69Histidine metabolism_Homo sapiens_hsa003401.06338558
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.99991786
71Carbon metabolism_Homo sapiens_hsa012000.99558125
72Galactose metabolism_Homo sapiens_hsa000520.99348326
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.98621663
74Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.98387969
75Base excision repair_Homo sapiens_hsa034100.98198817
76Proteoglycans in cancer_Homo sapiens_hsa052050.97805858
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96875946
78Basal transcription factors_Homo sapiens_hsa030220.96410572
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95712929
80Starch and sucrose metabolism_Homo sapiens_hsa005000.95593626
81Sulfur relay system_Homo sapiens_hsa041220.95585243
82ECM-receptor interaction_Homo sapiens_hsa045120.95276622
83Chemical carcinogenesis_Homo sapiens_hsa052040.94140182
84Rheumatoid arthritis_Homo sapiens_hsa053230.93942929
85Peroxisome_Homo sapiens_hsa041460.93749061
86p53 signaling pathway_Homo sapiens_hsa041150.93009439
87Salmonella infection_Homo sapiens_hsa051320.92350076
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92224568
89Fatty acid elongation_Homo sapiens_hsa000620.87249272
90Purine metabolism_Homo sapiens_hsa002300.87020912
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86861904
92One carbon pool by folate_Homo sapiens_hsa006700.86000932
93Measles_Homo sapiens_hsa051620.85530958
94Toll-like receptor signaling pathway_Homo sapiens_hsa046200.84104043
95Shigellosis_Homo sapiens_hsa051310.83289039
96Nucleotide excision repair_Homo sapiens_hsa034200.83189379
97Fatty acid degradation_Homo sapiens_hsa000710.83099639
98Selenocompound metabolism_Homo sapiens_hsa004500.83089470
99Allograft rejection_Homo sapiens_hsa053300.82628259
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.82488378
101Wnt signaling pathway_Homo sapiens_hsa043100.82138082
102Oxidative phosphorylation_Homo sapiens_hsa001900.80531434
103Retinol metabolism_Homo sapiens_hsa008300.80123847
104Regulation of autophagy_Homo sapiens_hsa041400.80059516
105Mineral absorption_Homo sapiens_hsa049780.79406950
106Primary bile acid biosynthesis_Homo sapiens_hsa001200.79035152
107Fanconi anemia pathway_Homo sapiens_hsa034600.76868948
108Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76134690
109Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75537434
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.74007227
111Small cell lung cancer_Homo sapiens_hsa052220.73743122
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70665700
113Axon guidance_Homo sapiens_hsa043600.69640164
114Maturity onset diabetes of the young_Homo sapiens_hsa049500.68584486
115Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68489251
116TNF signaling pathway_Homo sapiens_hsa046680.68264223
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.68069476
118Dilated cardiomyopathy_Homo sapiens_hsa054140.67394176
119Drug metabolism - other enzymes_Homo sapiens_hsa009830.65675835
120Graft-versus-host disease_Homo sapiens_hsa053320.65212409
121MicroRNAs in cancer_Homo sapiens_hsa052060.64285853
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64125128
123Fatty acid metabolism_Homo sapiens_hsa012120.63840355
124Spliceosome_Homo sapiens_hsa030400.63057608
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.62068438
126Metabolic pathways_Homo sapiens_hsa011000.61101009
127Pentose phosphate pathway_Homo sapiens_hsa000300.60488015
128Melanoma_Homo sapiens_hsa052180.59605926
129Apoptosis_Homo sapiens_hsa042100.57542417
130Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57274690
131ABC transporters_Homo sapiens_hsa020100.56113433
132Tuberculosis_Homo sapiens_hsa051520.53980690
133Fat digestion and absorption_Homo sapiens_hsa049750.53276015
134Huntingtons disease_Homo sapiens_hsa050160.53204199
135Complement and coagulation cascades_Homo sapiens_hsa046100.52764448
136Tyrosine metabolism_Homo sapiens_hsa003500.52594427
137Oocyte meiosis_Homo sapiens_hsa041140.51585520
138RNA polymerase_Homo sapiens_hsa030200.51265998
139beta-Alanine metabolism_Homo sapiens_hsa004100.50750430
140Caffeine metabolism_Homo sapiens_hsa002320.50745301
141Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49731692
142Asthma_Homo sapiens_hsa053100.49443105
143Arginine and proline metabolism_Homo sapiens_hsa003300.48248857
144Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47584091
145Legionellosis_Homo sapiens_hsa051340.47177265
146Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46271977
147Vibrio cholerae infection_Homo sapiens_hsa051100.46086096
148PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45478213
149Amoebiasis_Homo sapiens_hsa051460.45137371
150Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44483515
151Lysosome_Homo sapiens_hsa041420.43729042
152Mismatch repair_Homo sapiens_hsa034300.42211651
153Hepatitis C_Homo sapiens_hsa051600.40466877
154Steroid biosynthesis_Homo sapiens_hsa001000.39453087
155Primary immunodeficiency_Homo sapiens_hsa053400.38305835
156Influenza A_Homo sapiens_hsa051640.36622844

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