SNX8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1diaphragm development (GO:0060539)6.16680637
2pyrimidine-containing compound salvage (GO:0008655)6.08445439
3pyrimidine nucleoside salvage (GO:0043097)6.08445439
4regulation of interferon-beta biosynthetic process (GO:0045357)5.66124420
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.64940263
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.64940263
7modulation by symbiont of host immune response (GO:0052553)5.64940263
8positive regulation by symbiont of host defense response (GO:0052509)5.64940263
9modulation by symbiont of host defense response (GO:0052031)5.64940263
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.64940263
11skeletal muscle organ development (GO:0060538)5.31142150
12cellular protein complex localization (GO:0034629)5.25532887
13activation of MAPKKK activity (GO:0000185)5.12517694
14positive regulation of cell size (GO:0045793)4.98247883
15protein localization to endosome (GO:0036010)4.55483502
16nucleotide salvage (GO:0043173)4.50918390
17macrophage activation involved in immune response (GO:0002281)4.26041758
18positive regulation of interferon-alpha production (GO:0032727)4.22051251
19antigen processing and presentation of endogenous antigen (GO:0019883)4.21453270
20pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)4.14375415
21UMP biosynthetic process (GO:0006222)4.14375415
22pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)4.14375415
23UMP metabolic process (GO:0046049)4.14375415
24positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.05023525
25immunoglobulin mediated immune response (GO:0016064)4.04695272
263-UTR-mediated mRNA stabilization (GO:0070935)3.99433773
27regulation of interferon-alpha production (GO:0032647)3.96627073
28positive regulation of antigen processing and presentation (GO:0002579)3.93406234
29arginine catabolic process (GO:0006527)3.93296396
30nucleoside salvage (GO:0043174)3.87194945
31neutrophil activation involved in immune response (GO:0002283)3.86054064
32regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.81594911
33mannose metabolic process (GO:0006013)3.78766091
34negative regulation of calcium ion transport into cytosol (GO:0010523)3.77650188
35protein complex localization (GO:0031503)3.71850242
36pinocytosis (GO:0006907)3.71210160
37regulation of cholesterol storage (GO:0010885)3.67816599
38negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.67495307
39adenine nucleotide transport (GO:0051503)3.66689025
40low-density lipoprotein particle clearance (GO:0034383)3.66370505
41pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.66174585
42negative regulation of vascular permeability (GO:0043116)3.65548805
43cellular response to thyroid hormone stimulus (GO:0097067)3.64718054
44apoptotic cell clearance (GO:0043277)3.59198994
45negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.54453865
46dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.53326110
47regulation of dendritic cell antigen processing and presentation (GO:0002604)3.50432079
48glycosphingolipid catabolic process (GO:0046479)3.47946955
49natural killer cell mediated cytotoxicity (GO:0042267)3.47864744
50natural killer cell mediated immunity (GO:0002228)3.47864744
51L-alpha-amino acid transmembrane transport (GO:1902475)3.43997548
52antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.39270599
53antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.39270599
54positive regulation of gamma-delta T cell activation (GO:0046645)3.37794666
55pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.35874083
56regulation of integrin activation (GO:0033623)3.33083899
57B cell receptor signaling pathway (GO:0050853)3.32387303
58amino sugar catabolic process (GO:0046348)3.30707291
59negative regulation of alcohol biosynthetic process (GO:1902931)3.30356582
60lipopolysaccharide-mediated signaling pathway (GO:0031663)3.27385629
61NIK/NF-kappaB signaling (GO:0038061)3.24475983
62regulation of antigen processing and presentation (GO:0002577)3.22585857
63adhesion of symbiont to host (GO:0044406)3.22308796
64positive regulation of B cell differentiation (GO:0045579)3.20192311
65regulation of B cell receptor signaling pathway (GO:0050855)3.19033898
66phagosome maturation (GO:0090382)3.17734411
67regulation of cholesterol biosynthetic process (GO:0045540)3.17652520
68B cell mediated immunity (GO:0019724)3.17268567
69response to host immune response (GO:0052572)3.15980773
70response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.15980773
71response to thyroid hormone (GO:0097066)3.14181691
72positive regulation of interferon-beta production (GO:0032728)3.11210299
73antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.10847657
74positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.08915248
75regulation of monocyte differentiation (GO:0045655)3.08277802
76adhesion of symbiont to host cell (GO:0044650)3.07934885
77virion attachment to host cell (GO:0019062)3.07934885
78glycolipid catabolic process (GO:0019377)3.07531883
79negative regulation of macrophage differentiation (GO:0045650)3.06778644
80I-kappaB phosphorylation (GO:0007252)3.06208782
81respiratory burst (GO:0045730)3.05993736
82purine ribonucleotide transport (GO:0015868)3.03773858
83epithelial cell differentiation involved in prostate gland development (GO:0060742)3.02836099
84response to nerve growth factor (GO:1990089)3.02148744
85cellular response to nerve growth factor stimulus (GO:1990090)3.02148744
86barbed-end actin filament capping (GO:0051016)2.99545510
87response to host defenses (GO:0052200)2.99007387
88response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.99007387
89response to host (GO:0075136)2.99007387
90positive regulation of cell adhesion mediated by integrin (GO:0033630)2.97806797
91negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.97335597
92cytidine deamination (GO:0009972)2.96392575
93cytidine metabolic process (GO:0046087)2.96392575
94cytidine catabolic process (GO:0006216)2.96392575
95regulation of mononuclear cell migration (GO:0071675)2.96340840
96regulation of vitamin D biosynthetic process (GO:0060556)2.95636417
97lipoprotein transport (GO:0042953)2.93784027
98purine nucleotide transport (GO:0015865)2.93082222
99positive regulation of receptor biosynthetic process (GO:0010870)2.92601443
100positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.92051829
101oligosaccharide catabolic process (GO:0009313)2.91929942
102protein heterotrimerization (GO:0070208)2.88411997
103hypotonic response (GO:0006971)2.88219548
104myeloid dendritic cell differentiation (GO:0043011)2.85502572
105ncRNA 3-end processing (GO:0043628)2.83848699
106regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.83601148
107negative regulation of interleukin-12 production (GO:0032695)2.82684286
108response to muramyl dipeptide (GO:0032495)2.81040687
109cellular response to arsenic-containing substance (GO:0071243)2.80270763
110modulation by symbiont of host cellular process (GO:0044068)2.79720748
111positive regulation of DNA-dependent DNA replication (GO:2000105)2.79091034
112positive regulation of SMAD protein import into nucleus (GO:0060391)2.78635519
113regulation of early endosome to late endosome transport (GO:2000641)2.77471944
114negative regulation of granulocyte differentiation (GO:0030853)2.77104812
115positive regulation of T cell apoptotic process (GO:0070234)2.76271182
116positive regulation of p38MAPK cascade (GO:1900745)2.71904901
117regulation of membrane protein ectodomain proteolysis (GO:0051043)2.71866500
118negative regulation of interleukin-2 production (GO:0032703)2.71063406
119positive regulation of lymphocyte apoptotic process (GO:0070230)2.70871366
120nitric oxide biosynthetic process (GO:0006809)2.70707287
121positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.69559086
122mRNA stabilization (GO:0048255)2.66836355
123RNA stabilization (GO:0043489)2.66836355
124positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.64314414
125granulocyte activation (GO:0036230)2.63442915
126neutrophil activation (GO:0042119)2.62219692
127membrane lipid catabolic process (GO:0046466)2.61653368
128pentose-phosphate shunt (GO:0006098)2.61341290
129negative regulation of cell size (GO:0045792)2.61141930
130ceramide catabolic process (GO:0046514)2.59643814
131positive regulation of chemokine biosynthetic process (GO:0045080)2.58820599
132regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.58800114
133Rap protein signal transduction (GO:0032486)2.57671875
134arginine metabolic process (GO:0006525)2.57633252
135negative regulation of protein kinase B signaling (GO:0051898)2.56344183
136regulation of superoxide anion generation (GO:0032928)2.55683912
137sphingolipid catabolic process (GO:0030149)2.54866076
138basic amino acid transport (GO:0015802)2.53825267
139regulation of cytokine secretion involved in immune response (GO:0002739)2.53344665
140T-helper 1 type immune response (GO:0042088)2.52632829
141negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.52360459
142negative regulation of T cell receptor signaling pathway (GO:0050860)2.52017614
143regulation of interferon-beta production (GO:0032648)2.51831373
144response to laminar fluid shear stress (GO:0034616)2.51289157
145positive regulation of leukocyte degranulation (GO:0043302)2.50969632
146negative regulation of interleukin-6 production (GO:0032715)2.50131811
147cell adhesion mediated by integrin (GO:0033627)2.50041415
148hyaluronan catabolic process (GO:0030214)2.49783490
149myeloid cell homeostasis (GO:0002262)2.49645838
150endocytic recycling (GO:0032456)2.49114339
151regulation of B cell differentiation (GO:0045577)2.48914487
152regulation of SMAD protein import into nucleus (GO:0060390)2.47752595
153Arp2/3 complex-mediated actin nucleation (GO:0034314)2.47454214
154regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.47399973
155response to peptidoglycan (GO:0032494)2.46943396
156regulation of oxidative phosphorylation (GO:0002082)2.46727521
157macrophage activation (GO:0042116)2.46661829
158negative regulation of ERBB signaling pathway (GO:1901185)2.46324962
159positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.45803809
160urea cycle (GO:0000050)2.45232691
161regulation of mitochondrial translation (GO:0070129)2.44377659
162pyrimidine ribonucleoside catabolic process (GO:0046133)2.43820101
163regulation of gamma-delta T cell differentiation (GO:0045586)2.43533711
164apoptotic process involved in morphogenesis (GO:0060561)2.42981198
165regulation of interleukin-8 biosynthetic process (GO:0045414)2.42322040
166keratan sulfate catabolic process (GO:0042340)2.42141732
167response to lipoprotein particle (GO:0055094)2.41329633
168lymphocyte mediated immunity (GO:0002449)2.41306187
169NADPH regeneration (GO:0006740)2.40692133
170positive regulation of bone resorption (GO:0045780)2.39728933
171positive regulation of bone remodeling (GO:0046852)2.39728933
172regulation of gamma-delta T cell activation (GO:0046643)2.39711899
173regulation of interleukin-12 biosynthetic process (GO:0045075)2.38731883
174neutrophil mediated immunity (GO:0002446)2.37603223
175folic acid-containing compound biosynthetic process (GO:0009396)2.37174168
176maternal placenta development (GO:0001893)2.36928986
177T cell apoptotic process (GO:0070231)2.36776061
178leukocyte mediated cytotoxicity (GO:0001909)2.35976739
179myeloid cell activation involved in immune response (GO:0002275)2.31259225
180positive regulation of lipid storage (GO:0010884)2.28732419
181negative regulation of toll-like receptor signaling pathway (GO:0034122)2.27408362
182negative regulation of B cell proliferation (GO:0030889)2.26797006
183negative regulation of lipid storage (GO:0010888)2.26776981
184chaperone mediated protein folding requiring cofactor (GO:0051085)2.26756353

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse3.61771681
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.55711758
3E2F7_22180533_ChIP-Seq_HELA_Human3.17497384
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.02792585
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.77036690
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.69480387
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.64103290
8MYC_22102868_ChIP-Seq_BL_Human2.60780172
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.56708496
10VDR_21846776_ChIP-Seq_THP-1_Human2.51657289
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.42343816
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.36356829
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.30840603
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.23854064
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.03527029
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.02725667
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.00183746
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.95322191
19STAT6_21828071_ChIP-Seq_BEAS2B_Human1.93823067
20BRD4_27068464_Chip-Seq_AML-cells_Mouse1.90059632
21MYB_21317192_ChIP-Seq_ERMYB_Mouse1.89917204
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.87709070
23TFEB_21752829_ChIP-Seq_HELA_Human1.84644632
24ELK3_25401928_ChIP-Seq_HUVEC_Human1.82983404
25ZNF263_19887448_ChIP-Seq_K562_Human1.79899455
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.78434967
27ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.77735268
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.76356593
29PPARA_22158963_ChIP-Seq_LIVER_Mouse1.71875219
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.71533212
31PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.63496716
32TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63461340
33RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.61874851
34SMC4_20622854_ChIP-Seq_HELA_Human1.58162822
35* SPI1_23547873_ChIP-Seq_NB4_Human1.56699500
36KDM2B_26808549_Chip-Seq_K562_Human1.56212527
37RXR_22158963_ChIP-Seq_LIVER_Mouse1.54910101
38VDR_24763502_ChIP-Seq_THP-1_Human1.54278443
39MAF_26560356_Chip-Seq_TH1_Human1.53748891
40SCL_19346495_ChIP-Seq_HPC-7_Human1.53413362
41* TCF7_22412390_ChIP-Seq_EML_Mouse1.49729643
42* TET1_21451524_ChIP-Seq_MESCs_Mouse1.47021760
43PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.46945844
44LXR_22292898_ChIP-Seq_THP-1_Human1.43493855
45SPI1_23127762_ChIP-Seq_K562_Human1.42836510
46CLOCK_20551151_ChIP-Seq_293T_Human1.41551552
47STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37293679
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.36403701
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36203964
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35617935
51ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.34452006
52KDM2B_26808549_Chip-Seq_DND41_Human1.34162772
53RARG_19884340_ChIP-ChIP_MEFs_Mouse1.32175999
54KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31837081
55* P68_20966046_ChIP-Seq_HELA_Human1.30333582
56SA1_27219007_Chip-Seq_ERYTHROID_Human1.30206847
57* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29856824
58TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29245037
59KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26850383
60BP1_19119308_ChIP-ChIP_Hs578T_Human1.25899971
61SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24804336
62POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.23842656
63UTX_26944678_Chip-Seq_JUKART_Human1.23411814
64KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22920814
65GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21166950
66BCL6_27268052_Chip-Seq_Bcells_Human1.20741965
67CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20714166
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20096697
69VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19861193
70TP53_22127205_ChIP-Seq_IMR90_Human1.19385802
71GATA1_19941827_ChIP-Seq_MEL_Mouse1.19215890
72MYB_26560356_Chip-Seq_TH1_Human1.17311987
73RACK7_27058665_Chip-Seq_MCF-7_Human1.17135410
74CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16664701
75ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15749862
76MYC_18555785_ChIP-Seq_MESCs_Mouse1.14758847
77* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14166475
78TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13787395
79UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13731375
80KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13685242
81SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13463545
82* ATF3_27146783_Chip-Seq_COLON_Human1.13114485
83LXR_22158963_ChIP-Seq_LIVER_Mouse1.12699708
84GATA1_22025678_ChIP-Seq_K562_Human1.11659055
85GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10735920
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09874277
87EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09856595
88AR_21909140_ChIP-Seq_LNCAP_Human1.08596908
89KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08302133
90* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08272734
91KDM5A_27292631_Chip-Seq_BREAST_Human1.08145290
92CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07959261
93RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07896925
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07064063
95ESR2_21235772_ChIP-Seq_MCF-7_Human1.06841997
96NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06836213
97MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06813297
98PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06487009
99STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06237479
100TP63_17297297_ChIP-ChIP_HaCaT_Human1.05767343
101EZH2_22144423_ChIP-Seq_EOC_Human1.05000162
102* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04259256
103TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04245308
104TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03864176
105PU_27001747_Chip-Seq_BMDM_Mouse1.03321906
106P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03246447
107SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02986766
108NCOR1_26117541_ChIP-Seq_K562_Human1.02806351
109FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.02726847
110* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02366262
111MAF_26560356_Chip-Seq_TH2_Human1.01836744
112MYC_19079543_ChIP-ChIP_MESCs_Mouse1.01514513
113MYB_26560356_Chip-Seq_TH2_Human1.01258636
114* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.00492959
115NELFA_20434984_ChIP-Seq_ESCs_Mouse0.98749233
116TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98015421
117TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97470282
118KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96887644
119* BCOR_27268052_Chip-Seq_Bcells_Human0.96139677
120NANOG_18555785_ChIP-Seq_MESCs_Mouse0.96015084
121CIITA_25753668_ChIP-Seq_RAJI_Human0.95807294
122IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.94989393
123* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94517517
124* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94314619
125STAT4_19710469_ChIP-ChIP_TH1__Mouse0.94078452
126SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93803259
127FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.93267220
128SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.92760331
129ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90749432
130FOXO3_23340844_ChIP-Seq_DLD1_Human0.89968212
131NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.88702933
132POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.88244414
133MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.87226670
134HIF1A_21447827_ChIP-Seq_MCF-7_Human0.86873308

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.31122580
2MP0009840_abnormal_foam_cell3.93005197
3MP0003646_muscle_fatigue3.77407033
4MP0004233_abnormal_muscle_weight3.70758445
5MP0004858_abnormal_nervous_system3.50875847
6MP0001835_abnormal_antigen_presentation3.20142158
7MP0003303_peritoneal_inflammation3.11715021
8MP0000569_abnormal_digit_pigmentation3.07118236
9MP0000566_synostosis3.04621686
10MP0003172_abnormal_lysosome_physiology2.92251701
11MP0005167_abnormal_blood-brain_barrier2.88724274
12MP0003705_abnormal_hypodermis_morpholog2.57489410
13MP0005257_abnormal_intraocular_pressure2.39376169
14MP0001790_abnormal_immune_system2.31907815
15MP0005387_immune_system_phenotype2.31907815
16MP0000685_abnormal_immune_system2.29093218
17MP0003436_decreased_susceptibility_to2.27038827
18MP0001800_abnormal_humoral_immune2.10582487
19MP0003075_altered_response_to2.10288702
20MP0003191_abnormal_cellular_cholesterol2.07495583
21MP0006082_CNS_inflammation2.05016194
22MP0003300_gastrointestinal_ulcer2.01468989
23MP0002452_abnormal_antigen_presenting1.99536053
24MP0010307_abnormal_tumor_latency1.94960392
25MP0004510_myositis1.94147433
26MP0002419_abnormal_innate_immunity1.93762887
27MP0003566_abnormal_cell_adhesion1.89864781
28MP0005000_abnormal_immune_tolerance1.84926500
29MP0010368_abnormal_lymphatic_system1.82065718
30MP0002254_reproductive_system_inflammat1.81959288
31MP0000343_altered_response_to1.71711118
32MP0009278_abnormal_bone_marrow1.63962631
33MP0005076_abnormal_cell_differentiation1.63615082
34MP0008438_abnormal_cutaneous_collagen1.61627406
35MP0009053_abnormal_anal_canal1.58934572
36MP0002234_abnormal_pharynx_morphology1.58091995
37MP0002723_abnormal_immune_serum1.57828924
38MP0010352_gastrointestinal_tract_polyps1.55145373
39MP0005025_abnormal_response_to1.48333773
40MP0000604_amyloidosis1.47819823
41MP0003183_abnormal_peptide_metabolism1.46783466
42MP0001819_abnormal_immune_cell1.45642067
43MP0004947_skin_inflammation1.45517583
44MP0002420_abnormal_adaptive_immunity1.45352873
45MP0003045_fibrosis1.45156500
46MP0009764_decreased_sensitivity_to1.42855153
47MP0004043_abnormal_pH_regulation1.42769085
48MP0005464_abnormal_platelet_physiology1.40481902
49MP0000689_abnormal_spleen_morphology1.38358423
50MP0001958_emphysema1.38097852
51MP0003448_altered_tumor_morphology1.33904037
52MP0005360_urolithiasis1.31876532
53MP0000371_diluted_coat_color1.31284782
54MP0002405_respiratory_system_inflammati1.30075513
55MP0005310_abnormal_salivary_gland1.28464620
56MP0001845_abnormal_inflammatory_respons1.26750488
57MP0003806_abnormal_nucleotide_metabolis1.26663108
58MP0001533_abnormal_skeleton_physiology1.25669189
59MP0000490_abnormal_crypts_of1.22463282
60MP0002138_abnormal_hepatobiliary_system1.21334480
61MP0005166_decreased_susceptibility_to1.20775960
62MP0000716_abnormal_immune_system1.20047793
63MP0002136_abnormal_kidney_physiology1.19155539
64MP0005645_abnormal_hypothalamus_physiol1.17447986
65MP0002722_abnormal_immune_system1.14954954
66MP0002398_abnormal_bone_marrow1.14811839
67MP0002148_abnormal_hypersensitivity_rea1.14526893
68MP0003111_abnormal_nucleus_morphology1.12512686
69MP0009643_abnormal_urine_homeostasis1.10517620
70MP0008469_abnormal_protein_level1.09845263
71MP0009333_abnormal_splenocyte_physiolog1.09687404
72MP0003279_aneurysm1.08384267
73MP0000609_abnormal_liver_physiology1.07715830
74MP0002429_abnormal_blood_cell1.07245277
75MP0004185_abnormal_adipocyte_glucose1.05814088
76MP0003091_abnormal_cell_migration1.04032094
77MP0001873_stomach_inflammation1.02047565
78MP0000015_abnormal_ear_pigmentation1.00642589
79MP0001756_abnormal_urination0.99358017
80MP0005023_abnormal_wound_healing0.96979319
81MP0001849_ear_inflammation0.94586587
82MP0002877_abnormal_melanocyte_morpholog0.93654671
83MP0009785_altered_susceptibility_to0.92390689
84MP0003690_abnormal_glial_cell0.91735421
85MP0005670_abnormal_white_adipose0.91369258
86MP0004019_abnormal_vitamin_homeostasis0.91187365
87MP0003693_abnormal_embryo_hatching0.90979571
88MP0001853_heart_inflammation0.90902032
89MP0005671_abnormal_response_to0.90283522
90MP0003195_calcinosis0.90251013
91MP0000598_abnormal_liver_morphology0.89963751
92MP0005083_abnormal_biliary_tract0.89000168
93MP0005197_abnormal_uvea_morphology0.88475723
94MP0000467_abnormal_esophagus_morphology0.88048144
95MP0000858_altered_metastatic_potential0.87861153
96MP0003077_abnormal_cell_cycle0.87816184
97MP0001915_intracranial_hemorrhage0.85450721
98MP0008874_decreased_physiological_sensi0.84298735
99MP0002998_abnormal_bone_remodeling0.83859988
100MP0002396_abnormal_hematopoietic_system0.83651558
101MP0002139_abnormal_hepatobiliary_system0.83605958
102MP0002166_altered_tumor_susceptibility0.82390551
103MP0005174_abnormal_tail_pigmentation0.81862059
104MP0005332_abnormal_amino_acid0.81527497
105MP0000733_abnormal_muscle_development0.81421535
106MP0005390_skeleton_phenotype0.81221013
107MP0002135_abnormal_kidney_morphology0.79667906
108MP0005451_abnormal_body_composition0.78466749
109MP0005397_hematopoietic_system_phenotyp0.76771702
110MP0001545_abnormal_hematopoietic_system0.76771702
111MP0005621_abnormal_cell_physiology0.76211239
112MP0003634_abnormal_glial_cell0.74981506
113MP0001730_embryonic_growth_arrest0.74917947
114MP0002113_abnormal_skeleton_development0.74504231
115MP0003453_abnormal_keratinocyte_physiol0.74447436
116MP0005171_absent_coat_pigmentation0.72518471
117MP0008260_abnormal_autophagy0.72317334
118MP0000350_abnormal_cell_proliferation0.70413662
119MP0005319_abnormal_enzyme/_coenzyme0.69906346
120MP0010329_abnormal_lipoprotein_level0.69776397
121MP0003763_abnormal_thymus_physiology0.69345603
122MP0002933_joint_inflammation0.68296991
123MP0003329_amyloid_beta_deposits0.68205752
124MP0000358_abnormal_cell_content/0.67997948
125MP0003283_abnormal_digestive_organ0.67759198
126MP0004883_abnormal_blood_vessel0.67668379
127MP0000750_abnormal_muscle_regeneration0.67416582
128MP0005164_abnormal_response_to0.67007931
129MP0003656_abnormal_erythrocyte_physiolo0.65708294
130MP0001851_eye_inflammation0.65707016
131MP0001663_abnormal_digestive_system0.65696875
132MP0002019_abnormal_tumor_incidence0.65053041
133MP0000767_abnormal_smooth_muscle0.63561647
134MP0010155_abnormal_intestine_physiology0.61132184
135MP0003828_pulmonary_edema0.58362317
136MP0002089_abnormal_postnatal_growth/wei0.57292004

Predicted human phenotypes

RankGene SetZ-score
1Increased cerebral lipofuscin (HP:0011813)5.08286186
2Vacuolated lymphocytes (HP:0001922)4.76049476
3Sparse lateral eyebrow (HP:0005338)4.68916577
4Dysostosis multiplex (HP:0000943)4.40393991
5Recurrent abscess formation (HP:0002722)4.34236522
6Recurrent bacterial skin infections (HP:0005406)4.13482698
7Lip pit (HP:0100267)3.84403480
8Increased neuronal autofluorescent lipopigment (HP:0002074)3.83378842
9Abnormality of liposaccharide metabolism (HP:0010968)3.83131551
10Abnormality of glycosphingolipid metabolism (HP:0004343)3.83131551
11Abnormality of glycolipid metabolism (HP:0010969)3.83131551
12Urinary glycosaminoglycan excretion (HP:0003541)3.82930656
13Mucopolysacchariduria (HP:0008155)3.82930656
14Abnormality of mucopolysaccharide metabolism (HP:0011020)3.66193151
15Abnormality of polysaccharide metabolism (HP:0011012)3.66193151
16Abnormality of glycosaminoglycan metabolism (HP:0004371)3.66193151
17Abnormality of macrophages (HP:0004311)3.65434305
18Systemic lupus erythematosus (HP:0002725)3.63274501
19Anal stenosis (HP:0002025)3.60193559
20Eczematoid dermatitis (HP:0000976)3.51261357
21Loss of speech (HP:0002371)3.48176147
22Ureteral stenosis (HP:0000071)3.48013215
23Axonal loss (HP:0003447)3.41429363
24Intestinal fistula (HP:0100819)3.37741026
25Abnormality of the fingertips (HP:0001211)3.31120419
26Recurrent gram-negative bacterial infections (HP:0005420)3.29906992
27Disinhibition (HP:0000734)3.19737531
28Progressive neurologic deterioration (HP:0002344)3.18226588
29Ureteral obstruction (HP:0006000)3.17140055
30Global brain atrophy (HP:0002283)3.07423623
31Myocardial infarction (HP:0001658)3.07316065
32Natal tooth (HP:0000695)3.01198732
33Colitis (HP:0002583)2.98939690
34Long palpebral fissure (HP:0000637)2.98769635
35Cellulitis (HP:0100658)2.94850844
36Cerebral aneurysm (HP:0004944)2.89141198
37Short 5th finger (HP:0009237)2.89043633
38Hand muscle atrophy (HP:0009130)2.82483891
39Autoimmune thrombocytopenia (HP:0001973)2.77223255
40Lower limb hyperreflexia (HP:0002395)2.76647059
41Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.75387511
42Nuclear cataract (HP:0100018)2.74667750
43Abnormality of the distal phalanges of the toes (HP:0010182)2.74203601
44Upper motor neuron abnormality (HP:0002127)2.65245681
45Glomerulonephritis (HP:0000099)2.61663824
46Asymmetric septal hypertrophy (HP:0001670)2.58657892
47Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.58657563
48Recurrent skin infections (HP:0001581)2.57614309
49Trismus (HP:0000211)2.56705558
50Pathologic fracture (HP:0002756)2.53491460
51Abnormality of the periventricular white matter (HP:0002518)2.53461821
52Depressed nasal tip (HP:0000437)2.52970882
53Gingivitis (HP:0000230)2.51864192
54Distal upper limb amyotrophy (HP:0007149)2.48076122
55Upper limb amyotrophy (HP:0009129)2.48076122
56Personality changes (HP:0000751)2.47763214
57Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.45716009
58Emphysema (HP:0002097)2.43165412
59Petechiae (HP:0000967)2.39755511
60Hyperacusis (HP:0010780)2.38929262
61Pustule (HP:0200039)2.37075117
62Tetraparesis (HP:0002273)2.36532257
63Recurrent fungal infections (HP:0002841)2.34154303
64Hypertensive crisis (HP:0100735)2.33476576
65Interstitial pulmonary disease (HP:0006530)2.31137193
66Agnosia (HP:0010524)2.29508486
67Gastrointestinal stroma tumor (HP:0100723)2.28370841
68Peripheral demyelination (HP:0011096)2.27757479
69Osteomyelitis (HP:0002754)2.26338773
70Hematochezia (HP:0002573)2.24913660
71Mediastinal lymphadenopathy (HP:0100721)2.24461195
72Achilles tendon contracture (HP:0001771)2.21344680
73Osteolytic defects of the hand bones (HP:0009699)2.21084431
74Osteolytic defects of the phalanges of the hand (HP:0009771)2.21084431
75Vertebral hypoplasia (HP:0008417)2.19361934
76Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.19361934
77Recurrent viral infections (HP:0004429)2.19168792
78Inflammation of the large intestine (HP:0002037)2.18626815
79Cervical subluxation (HP:0003308)2.18135885
80Gastrointestinal inflammation (HP:0004386)2.16499957
81Posterior subcapsular cataract (HP:0007787)2.15096055
82Abnormality of the vasculature of the conjunctiva (HP:0008054)2.14767415
83Abnormality of complement system (HP:0005339)2.14372102
84Increased CSF protein (HP:0002922)2.13867595
85Vertebral compression fractures (HP:0002953)2.12139184
86Poor head control (HP:0002421)2.11351804
87Fatigue (HP:0012378)2.11318233
88Xanthomatosis (HP:0000991)2.08758938
89Agammaglobulinemia (HP:0004432)2.08192132
90Periodontitis (HP:0000704)2.05794351
91Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.02309086
92Thoracic kyphosis (HP:0002942)2.01775604
93Ulnar bowing (HP:0003031)2.01699401
94Polycythemia (HP:0001901)2.00062085
95Obstructive sleep apnea (HP:0002870)1.98036473
96Reduced subcutaneous adipose tissue (HP:0003758)1.97457340
97Metaphyseal cupping (HP:0003021)1.96648814
98Neuronal loss in central nervous system (HP:0002529)1.95105381
99Neurofibrillary tangles (HP:0002185)1.94454866
100Abnormality of the Achilles tendon (HP:0005109)1.93783451
101Subcapsular cataract (HP:0000523)1.92266736
102J-shaped sella turcica (HP:0002680)1.91256509
103Bone pain (HP:0002653)1.90966167
104Mitral stenosis (HP:0001718)1.90653715
105Restrictive lung disease (HP:0002091)1.90510334
106Esophageal varix (HP:0002040)1.89259183
107Purpura (HP:0000979)1.89174172
108Cortical dysplasia (HP:0002539)1.88746897
109Conjunctival telangiectasia (HP:0000524)1.87569766
110Complement deficiency (HP:0004431)1.87138315
111Prolonged neonatal jaundice (HP:0006579)1.86756682
112Neonatal death (HP:0003811)1.86342130
113Papilloma (HP:0012740)1.86302867
114Verrucae (HP:0200043)1.86302867
115Renal cell carcinoma (HP:0005584)1.84961718
116Rough bone trabeculation (HP:0100670)1.83963935
117Increased serum ferritin (HP:0003281)1.83623672
118Nephritis (HP:0000123)1.80333299
119Centrally nucleated skeletal muscle fibers (HP:0003687)1.78121201
120Chronic mucocutaneous candidiasis (HP:0002728)1.77849645
121Recurrent cutaneous fungal infections (HP:0011370)1.77849645
122Ectropion (HP:0000656)1.76986299
123Abnormality of the thoracic spine (HP:0100711)1.76960148
124Diminished motivation (HP:0000745)1.75490128
125Increased connective tissue (HP:0009025)1.74423578
126Premature rupture of membranes (HP:0001788)1.74177495
127Popliteal pterygium (HP:0009756)1.73420216
128Uterine leiomyosarcoma (HP:0002891)1.72239201
129Leiomyosarcoma (HP:0100243)1.72239201
130Neurodegeneration (HP:0002180)1.71859671
131Hepatosplenomegaly (HP:0001433)1.71733015
132Mutism (HP:0002300)1.71066303
133Abnormality of iron homeostasis (HP:0011031)1.70846488
134Abnormality of the lumbar spine (HP:0100712)1.70838433
135Blue sclerae (HP:0000592)1.69374336
136Apathy (HP:0000741)1.69371242
137Vasculitis (HP:0002633)1.68685530
138Abnormal trabecular bone morphology (HP:0100671)1.68522378
139Cerebral inclusion bodies (HP:0100314)1.67897347
140Hypokinesia (HP:0002375)1.67819425
141Distal lower limb muscle weakness (HP:0009053)1.67494090
142Neonatal short-limb short stature (HP:0008921)1.67460046
143Nausea (HP:0002018)1.67322299
144Obstructive lung disease (HP:0006536)1.66633585
145Chronic obstructive pulmonary disease (HP:0006510)1.66633585
146Urticaria (HP:0001025)1.66561189
147Thin bony cortex (HP:0002753)1.66080010
148Gout (HP:0001997)1.65954973
149Spinal muscular atrophy (HP:0007269)1.65861486
150Advanced eruption of teeth (HP:0006288)1.65457071
151Distal lower limb amyotrophy (HP:0008944)1.65242917
152Abnormality of transition element cation homeostasis (HP:0011030)1.64836027
153Premature loss of primary teeth (HP:0006323)1.62972918
154Mucosal telangiectasiae (HP:0100579)1.62819306
155Disproportionate tall stature (HP:0001519)1.62410568
156Abnormality of glutamine family amino acid metabolism (HP:0010902)1.59158297
157Recurrent pneumonia (HP:0006532)1.59103995

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK245.57817505
2ERN13.92502131
3TRIB33.49453411
4CCNB13.01431769
5MAP4K12.87096894
6BLK2.63225956
7WNK42.57866048
8MAP3K102.56707948
9PRPF4B2.52530886
10STK392.46536761
11PKN22.42715012
12SCYL22.41269417
13MAP3K22.40957222
14TYK22.26218821
15TBK12.12172396
16KIT2.00310383
17BUB11.92400128
18ILK1.87119601
19TAOK21.86268219
20TTN1.82402042
21CSF1R1.78899644
22NEK21.78730492
23MAPKAPK31.75783541
24LRRK21.75659135
25CDK121.75091403
26PTK61.65534416
27MAP3K141.64049233
28STK101.63757158
29DDR21.63462285
30CAMK1D1.55244820
31TGFBR21.51232409
32MAP2K31.50055089
33GRK61.46984855
34IKBKB1.42636599
35IRAK31.39279835
36SMG11.39040758
37RPS6KA41.28974824
38RPS6KC11.28109459
39RPS6KL11.28109459
40MAP3K31.24715358
41JAK11.24703604
42EEF2K1.24657601
43EPHB11.24605092
44PAK41.20965989
45RIPK41.18554816
46BMX1.13935548
47PINK11.11627922
48NEK91.10842891
49BTK1.10689584
50KDR1.10194610
51NME21.08127289
52CHUK1.07911299
53RPS6KA61.07189366
54SYK1.07179144
55IRAK41.04042493
56ALK1.00189697
57SIK20.99709222
58ZAP700.99002722
59RIPK10.98745438
60CSK0.98621495
61MAP3K110.97948845
62SIK10.96359345
63JAK30.96309438
64PIM10.94489816
65MAP3K80.93516328
66HCK0.93283522
67FGFR40.92313103
68RPS6KA20.90071907
69CHEK20.89966930
70CAMK1G0.88113114
71MTOR0.87553866
72NEK10.87445033
73MAP3K130.86430076
74CDC42BPA0.86369689
75TESK20.86131488
76JAK20.85646396
77CDK40.84894087
78TAOK30.81614018
79CDK60.81229876
80MARK30.80462760
81BCKDK0.80189248
82CAMK40.78897953
83ARAF0.78778130
84EPHA20.78148549
85TRPM70.77827676
86LYN0.74865075
87RPS6KB20.74323202
88TAOK10.72461181
89WNK10.72160736
90DYRK1B0.70342395
91MST1R0.68886994
92EGFR0.66606814
93PRKCQ0.65898133
94GRK70.65457549
95FGFR30.65084161
96STK40.62973002
97CDK90.62835243
98PTK20.62649128
99ICK0.61850497
100MOS0.61599791
101LMTK20.61450185
102MATK0.59693373
103STK30.58759621
104IKBKE0.57017149
105CAMK10.56629840
106MAPK110.56435534
107IRAK20.52867340
108PAK20.50366408
109CDC70.50203676
110DYRK30.49615527
111LATS20.49312740
112FLT30.49190626
113PRKG20.48099510
114PIM20.47651655
115PDGFRA0.47282787
116DAPK30.47184631
117LCK0.47004519
118ABL10.46665237
119FGR0.45686066
120MAP3K10.44752023
121ABL20.43458815
122LIMK10.41906702
123PDPK10.41768586
124MAPKAPK50.40076255
125EIF2AK10.39380405
126WEE10.38641023
127KSR20.37261949
128MAP2K20.36931180
129EPHA30.36877314
130PRKCD0.36604174
131ITK0.35547951
132GSK3A0.34998912
133PAK10.34599639
134TESK10.34290241
135PLK10.33154344
136FES0.32721427
137MAPK120.31598379
138CDK70.31457659
139TTK0.29529198
140MAPKAPK20.29516638
141PDK20.28908653
142AKT20.28503636
143TLK10.28501591
144MAP3K50.27237882
145BRAF0.25720850
146ZAK0.24786376

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005313.71405380
2Lysosome_Homo sapiens_hsa041423.57542029
3Other glycan degradation_Homo sapiens_hsa005112.75406856
4B cell receptor signaling pathway_Homo sapiens_hsa046622.58143567
5Staphylococcus aureus infection_Homo sapiens_hsa051502.50770479
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.22622613
7Asthma_Homo sapiens_hsa053102.20376272
8Allograft rejection_Homo sapiens_hsa053302.19334950
9Leishmaniasis_Homo sapiens_hsa051401.95446055
10Osteoclast differentiation_Homo sapiens_hsa043801.94536684
11Antigen processing and presentation_Homo sapiens_hsa046121.93112249
12Autoimmune thyroid disease_Homo sapiens_hsa053201.81750790
13Graft-versus-host disease_Homo sapiens_hsa053321.81487187
14Tuberculosis_Homo sapiens_hsa051521.69782994
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.68973576
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.57962038
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.57562018
18Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.52615539
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.50436011
20Apoptosis_Homo sapiens_hsa042101.48952625
21Phagosome_Homo sapiens_hsa041451.34300093
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.33974591
23Caffeine metabolism_Homo sapiens_hsa002321.32538461
24One carbon pool by folate_Homo sapiens_hsa006701.31301811
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.30392574
26Legionellosis_Homo sapiens_hsa051341.26397237
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.25970410
28Chronic myeloid leukemia_Homo sapiens_hsa052201.25148230
29Complement and coagulation cascades_Homo sapiens_hsa046101.23742299
30Type I diabetes mellitus_Homo sapiens_hsa049401.21621961
31Pertussis_Homo sapiens_hsa051331.19204329
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.15800503
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.15251591
34Vibrio cholerae infection_Homo sapiens_hsa051101.15165924
35Selenocompound metabolism_Homo sapiens_hsa004501.15162504
36N-Glycan biosynthesis_Homo sapiens_hsa005101.10040686
37Toxoplasmosis_Homo sapiens_hsa051451.07781545
38Malaria_Homo sapiens_hsa051441.04639111
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04576994
40Lysine degradation_Homo sapiens_hsa003101.03858959
41Shigellosis_Homo sapiens_hsa051311.00004845
42Primary immunodeficiency_Homo sapiens_hsa053400.99333372
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99244286
44Sphingolipid signaling pathway_Homo sapiens_hsa040710.98617395
45Viral carcinogenesis_Homo sapiens_hsa052030.98501955
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97413835
47Small cell lung cancer_Homo sapiens_hsa052220.97154804
48Intestinal immune network for IgA production_Homo sapiens_hsa046720.95815588
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94588854
50Measles_Homo sapiens_hsa051620.91674009
51Influenza A_Homo sapiens_hsa051640.87732241
52AMPK signaling pathway_Homo sapiens_hsa041520.87122368
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86900244
54Pancreatic cancer_Homo sapiens_hsa052120.85925564
55NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85634642
56mTOR signaling pathway_Homo sapiens_hsa041500.85600227
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84639369
58Arginine biosynthesis_Homo sapiens_hsa002200.83443774
59Leukocyte transendothelial migration_Homo sapiens_hsa046700.82037688
60Pentose phosphate pathway_Homo sapiens_hsa000300.81978286
61Vitamin B6 metabolism_Homo sapiens_hsa007500.81005229
62Acute myeloid leukemia_Homo sapiens_hsa052210.80694265
63Epstein-Barr virus infection_Homo sapiens_hsa051690.79689501
64Notch signaling pathway_Homo sapiens_hsa043300.79368427
65Herpes simplex infection_Homo sapiens_hsa051680.79045679
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.78677074
67Renal cell carcinoma_Homo sapiens_hsa052110.77045354
68p53 signaling pathway_Homo sapiens_hsa041150.76742256
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76133784
70Hepatitis B_Homo sapiens_hsa051610.75929620
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72885565
72TNF signaling pathway_Homo sapiens_hsa046680.71123911
73Biosynthesis of amino acids_Homo sapiens_hsa012300.70842528
74Insulin resistance_Homo sapiens_hsa049310.70667675
75Viral myocarditis_Homo sapiens_hsa054160.70631276
76Sphingolipid metabolism_Homo sapiens_hsa006000.70564722
77Proteoglycans in cancer_Homo sapiens_hsa052050.70492743
78Galactose metabolism_Homo sapiens_hsa000520.70322773
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.69410524
80Pyrimidine metabolism_Homo sapiens_hsa002400.69363303
81MicroRNAs in cancer_Homo sapiens_hsa052060.69361417
82Bladder cancer_Homo sapiens_hsa052190.68952280
83Fructose and mannose metabolism_Homo sapiens_hsa000510.68023766
84Endocytosis_Homo sapiens_hsa041440.67916272
85Nitrogen metabolism_Homo sapiens_hsa009100.67862190
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66100071
87Rheumatoid arthritis_Homo sapiens_hsa053230.65910278
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.65767975
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65353992
90Vitamin digestion and absorption_Homo sapiens_hsa049770.64585517
91Base excision repair_Homo sapiens_hsa034100.64449416
92Hepatitis C_Homo sapiens_hsa051600.64016778
93Collecting duct acid secretion_Homo sapiens_hsa049660.63421013
94African trypanosomiasis_Homo sapiens_hsa051430.63050353
95Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62970277
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62745306
97PPAR signaling pathway_Homo sapiens_hsa033200.62289090
98Insulin signaling pathway_Homo sapiens_hsa049100.61202746
99Chemokine signaling pathway_Homo sapiens_hsa040620.59805463
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.58312271
101Amoebiasis_Homo sapiens_hsa051460.57957068
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.57924196
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57230216
104Tryptophan metabolism_Homo sapiens_hsa003800.56332567
105HIF-1 signaling pathway_Homo sapiens_hsa040660.55884870
106Hematopoietic cell lineage_Homo sapiens_hsa046400.55443535
107Folate biosynthesis_Homo sapiens_hsa007900.54472027
108Non-small cell lung cancer_Homo sapiens_hsa052230.54110554
109Renin-angiotensin system_Homo sapiens_hsa046140.53761056
110Systemic lupus erythematosus_Homo sapiens_hsa053220.53636451
111Sulfur relay system_Homo sapiens_hsa041220.53088092
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.52411731
113Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52101357
114Carbon metabolism_Homo sapiens_hsa012000.51747461
115Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51490724
116Prion diseases_Homo sapiens_hsa050200.51137932
117HTLV-I infection_Homo sapiens_hsa051660.50626087
118Fatty acid degradation_Homo sapiens_hsa000710.48951372
119Salmonella infection_Homo sapiens_hsa051320.48633543
120DNA replication_Homo sapiens_hsa030300.48625478
121VEGF signaling pathway_Homo sapiens_hsa043700.44730093
122Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44203112
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40921541
124Glioma_Homo sapiens_hsa052140.40342061
125Focal adhesion_Homo sapiens_hsa045100.38004597

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