SNX9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the sorting nexin family. Members of this family contain a phosphoinositide binding domain, and are involved in intracellular trafficking. The encoded protein does not contain a coiled coil region, like some family members, but does contain a SRC homology domain near its N-terminus. The encoded protein is reported to have a variety of interaction partners, including of adaptor protein 2 , dynamin, tyrosine kinase non-receptor 2, Wiskott-Aldrich syndrome-like, and ARP3 actin-related protein 3. The encoded protein is implicated in several stages of intracellular trafficking, including endocytosis, macropinocytosis, and F-actin nucleation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of vitamin D biosynthetic process (GO:0060556)4.56847529
2regulation of vitamin metabolic process (GO:0030656)4.02382667
3adhesion of symbiont to host cell (GO:0044650)3.90600963
4virion attachment to host cell (GO:0019062)3.90600963
5low-density lipoprotein particle clearance (GO:0034383)3.75672913
6* positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.69090388
7adhesion of symbiont to host (GO:0044406)3.65671321
8regulation of early endosome to late endosome transport (GO:2000641)3.63991979
9protein localization to endosome (GO:0036010)3.63810713
10positive regulation of extracellular matrix organization (GO:1903055)3.61404021
11apoptotic cell clearance (GO:0043277)3.60972788
12regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.52573958
13negative regulation of fibrinolysis (GO:0051918)3.48632368
14regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.48589070
15barbed-end actin filament capping (GO:0051016)3.46374744
16* regulation of membrane protein ectodomain proteolysis (GO:0051043)3.38832239
17regulation of mononuclear cell migration (GO:0071675)3.36287592
18triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.30770295
19positive regulation of chemokine biosynthetic process (GO:0045080)3.27878773
20protein carboxylation (GO:0018214)3.23412670
21peptidyl-glutamic acid carboxylation (GO:0017187)3.23412670
22cell adhesion mediated by integrin (GO:0033627)3.11762501
23fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.11635308
24lysine metabolic process (GO:0006553)3.09011113
25lysine catabolic process (GO:0006554)3.09011113
26hyaluronan catabolic process (GO:0030214)3.07494773
27alpha-linolenic acid metabolic process (GO:0036109)3.06537581
28stress fiber assembly (GO:0043149)3.06088490
29sulfur amino acid catabolic process (GO:0000098)3.04653056
30urea cycle (GO:0000050)3.04063149
31urea metabolic process (GO:0019627)3.04063149
32plasma lipoprotein particle clearance (GO:0034381)3.03575351
33regulation of cholesterol storage (GO:0010885)3.02826656
34regulation of cholesterol homeostasis (GO:2000188)3.00639858
35positive regulation of fatty acid beta-oxidation (GO:0032000)3.00034383
36positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.99366801
37cysteine metabolic process (GO:0006534)2.98458615
38Golgi transport vesicle coating (GO:0048200)2.96854475
39COPI coating of Golgi vesicle (GO:0048205)2.96854475
40regulation of fatty acid beta-oxidation (GO:0031998)2.93367324
41decidualization (GO:0046697)2.91860474
42cellular response to thyroid hormone stimulus (GO:0097067)2.91738376
43lipopolysaccharide-mediated signaling pathway (GO:0031663)2.90709895
44negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.88745451
45regulation of extracellular matrix disassembly (GO:0010715)2.86182003
46endodermal cell differentiation (GO:0035987)2.85490467
47growth hormone receptor signaling pathway (GO:0060396)2.85376273
48lipoprotein metabolic process (GO:0042157)2.82100393
49glycosphingolipid catabolic process (GO:0046479)2.81557441
50pinocytosis (GO:0006907)2.81533632
51skin morphogenesis (GO:0043589)2.79618471
52response to laminar fluid shear stress (GO:0034616)2.78763887
53regulation of transforming growth factor beta1 production (GO:0032908)2.78709394
54homocysteine metabolic process (GO:0050667)2.78475439
55regulation of protein activation cascade (GO:2000257)2.75449571
56regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.74123672
57oligosaccharide catabolic process (GO:0009313)2.74089465
58hypotonic response (GO:0006971)2.73309775
59regulation of chemokine biosynthetic process (GO:0045073)2.72822198
60regulation of fibrinolysis (GO:0051917)2.72181034
61erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.71652389
62L-phenylalanine metabolic process (GO:0006558)2.71652389
63substrate-dependent cell migration (GO:0006929)2.70556898
64regulation of complement activation (GO:0030449)2.69510239
65keratan sulfate catabolic process (GO:0042340)2.69494397
66epoxygenase P450 pathway (GO:0019373)2.68912033
67negative regulation of lipid transport (GO:0032369)2.68740423
68nitrogen cycle metabolic process (GO:0071941)2.68674569
694-hydroxyproline metabolic process (GO:0019471)2.68005855
70complement activation, alternative pathway (GO:0006957)2.67242396
71L-phenylalanine catabolic process (GO:0006559)2.66392773
72erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.66392773
73glyoxylate metabolic process (GO:0046487)2.64175044
74negative regulation of fatty acid transport (GO:2000192)2.63889344
75positive regulation of lipid catabolic process (GO:0050996)2.63353788
76negative regulation of nitric oxide biosynthetic process (GO:0045019)2.62735567
77regulation of triglyceride catabolic process (GO:0010896)2.61089291
78negative regulation of protein localization to plasma membrane (GO:1903077)2.60685389
79kynurenine metabolic process (GO:0070189)2.60669642
80fibrinolysis (GO:0042730)2.58975543
81negative regulation of sterol transport (GO:0032372)2.58973414
82negative regulation of cholesterol transport (GO:0032375)2.58973414
83intestinal cholesterol absorption (GO:0030299)2.58183093
84collagen metabolic process (GO:0032963)2.57894871
85positive regulation of p38MAPK cascade (GO:1900745)2.57691695
86endocytic recycling (GO:0032456)2.56515767
87phospholipid homeostasis (GO:0055091)2.55692606
88glycolipid catabolic process (GO:0019377)2.55514075
89response to thyroid hormone (GO:0097066)2.55462965
90aromatic amino acid family catabolic process (GO:0009074)2.55035761
91high-density lipoprotein particle remodeling (GO:0034375)2.52941704
92basement membrane organization (GO:0071711)2.51884256
93regulation of extracellular matrix organization (GO:1903053)2.51549529
94regulation of podosome assembly (GO:0071801)2.51249603
95vascular endothelial growth factor signaling pathway (GO:0038084)2.50644684
96regulation of plasminogen activation (GO:0010755)2.48998394
97fibril organization (GO:0097435)2.48397179
98amino-acid betaine metabolic process (GO:0006577)2.47754008
99antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.47745161
100positive regulation of blood coagulation (GO:0030194)2.47670217
101positive regulation of hemostasis (GO:1900048)2.47670217
102negative regulation of focal adhesion assembly (GO:0051895)2.47284040
103negative regulation of cell junction assembly (GO:1901889)2.47284040
104negative regulation of adherens junction organization (GO:1903392)2.47284040
105collagen catabolic process (GO:0030574)2.46737684
106epithelial cell-cell adhesion (GO:0090136)2.46657024
107regulation of cytokine secretion involved in immune response (GO:0002739)2.46152126
108cell-substrate junction assembly (GO:0007044)2.45902762
109reverse cholesterol transport (GO:0043691)2.45144116
110antigen processing and presentation of endogenous antigen (GO:0019883)2.44951329
111collagen fibril organization (GO:0030199)2.44730227
112NIK/NF-kappaB signaling (GO:0038061)2.44681504
113negative regulation of lipid storage (GO:0010888)2.44521531
114multicellular organismal macromolecule metabolic process (GO:0044259)2.43453053
115phospholipid efflux (GO:0033700)2.42713855
116regulation of fever generation (GO:0031620)2.41927917
117valine metabolic process (GO:0006573)2.41921597
118antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.41559084
119antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.41559084
120plasma lipoprotein particle assembly (GO:0034377)2.41112540
121cellular response to growth hormone stimulus (GO:0071378)2.39817218
122embryo implantation (GO:0007566)2.39621922
123negative regulation of anoikis (GO:2000811)2.38982503
124indole-containing compound catabolic process (GO:0042436)2.38351067
125indolalkylamine catabolic process (GO:0046218)2.38351067
126tryptophan catabolic process (GO:0006569)2.38351067
127wound healing, spreading of epidermal cells (GO:0035313)2.38205783
128positive regulation of fatty acid oxidation (GO:0046321)2.38091433
129intestinal absorption (GO:0050892)2.36442581
130chondrocyte proliferation (GO:0035988)2.35843327
131positive regulation of coagulation (GO:0050820)2.35737199
132protein heterotrimerization (GO:0070208)2.35367777
133cell migration involved in heart development (GO:0060973)2.35334937
134multicellular organismal catabolic process (GO:0044243)2.35278291
135myeloid dendritic cell differentiation (GO:0043011)2.35132039
136response to growth hormone (GO:0060416)2.34988630
137regulation of macrophage chemotaxis (GO:0010758)2.34458080
138regulation of interferon-beta biosynthetic process (GO:0045357)2.34316638
139multicellular organismal metabolic process (GO:0044236)2.34044766
140retina vasculature morphogenesis in camera-type eye (GO:0061299)2.33883775
141sterol homeostasis (GO:0055092)2.33596913
1422-oxoglutarate metabolic process (GO:0006103)2.33308893
143vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.33101271
144COPII vesicle coating (GO:0048208)2.32478391
145positive regulation of receptor recycling (GO:0001921)2.32203001
146positive regulation of blood vessel endothelial cell migration (GO:0043536)2.32191930
147cellular response to arsenic-containing substance (GO:0071243)2.32044556
148positive regulation of heat generation (GO:0031652)2.31261733
149embryonic process involved in female pregnancy (GO:0060136)2.30850972
150extracellular matrix assembly (GO:0085029)2.30823196
151negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.30753593
152cholesterol homeostasis (GO:0042632)2.30575171
153positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.30283962
154negative regulation of erythrocyte differentiation (GO:0045647)2.29910342
155negative regulation of homotypic cell-cell adhesion (GO:0034111)2.29321766
156regulation of integrin activation (GO:0033623)2.28960119
157tryptophan metabolic process (GO:0006568)2.28831003
158urate metabolic process (GO:0046415)2.28685543
159positive regulation of lipid storage (GO:0010884)2.27650177
160plasma lipoprotein particle remodeling (GO:0034369)2.27572420
161protein-lipid complex remodeling (GO:0034368)2.27572420
162macromolecular complex remodeling (GO:0034367)2.27572420
163sequestering of extracellular ligand from receptor (GO:0035581)2.27514203
164cellular glucuronidation (GO:0052695)2.27255024
165regulation of p38MAPK cascade (GO:1900744)2.26684409
166extracellular matrix disassembly (GO:0022617)2.26522794
167negative regulation of smooth muscle cell migration (GO:0014912)2.26196647
168drug catabolic process (GO:0042737)2.25663398
169regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.25370653
170membrane raft organization (GO:0031579)2.24792708
171mannose metabolic process (GO:0006013)2.24398850
172blood vessel maturation (GO:0001955)2.24206571
173bile acid biosynthetic process (GO:0006699)2.23967174
174hyaluronan metabolic process (GO:0030212)2.23964503
175ovulation (GO:0030728)2.23581806
176positive regulation of triglyceride metabolic process (GO:0090208)2.22343448
177* protein-lipid complex assembly (GO:0065005)2.20939465
178pentose-phosphate shunt (GO:0006098)2.20866147
179positive regulation of endothelial cell apoptotic process (GO:2000353)2.20434374
180hepatocyte apoptotic process (GO:0097284)2.20313835
181acylglycerol homeostasis (GO:0055090)2.20049537
182triglyceride homeostasis (GO:0070328)2.20049537

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.96291073
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.75283273
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.54618176
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.53699406
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.45298077
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.14330790
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.10928276
8CLOCK_20551151_ChIP-Seq_293T_Human2.73433632
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.69213768
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.62713134
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.56565495
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.54699521
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.36050691
14EGR1_23403033_ChIP-Seq_LIVER_Mouse2.20317296
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.20263615
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.09163412
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.07351501
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.06619331
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.05638521
20* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.01821613
21NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.88214112
22TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.87384021
23IRF8_21731497_ChIP-ChIP_J774_Mouse1.85878398
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.85815186
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.76322698
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.75845282
27* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.75736303
28FOXM1_23109430_ChIP-Seq_U2OS_Human1.75335907
29KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.72058222
30SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71197732
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.69888052
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.68545533
33IRF8_27001747_Chip-Seq_BMDM_Mouse1.67940232
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.65589488
35RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.65588604
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.65194069
37MYC_22102868_ChIP-Seq_BL_Human1.59725258
38FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.59450580
39STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.58790545
40AR_21909140_ChIP-Seq_LNCAP_Human1.58580702
41CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.58503928
42FOXO3_23340844_ChIP-Seq_DLD1_Human1.53262377
43HIF1A_21447827_ChIP-Seq_MCF-7_Human1.52264575
44* ATF3_27146783_Chip-Seq_COLON_Human1.52165857
45* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.50922575
46ZNF263_19887448_ChIP-Seq_K562_Human1.48891845
47LXR_22292898_ChIP-Seq_THP-1_Human1.46296654
48ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.44334511
49* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.43385256
50STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.42415689
51* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.37130879
52HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.36865206
53WT1_19549856_ChIP-ChIP_CCG9911_Human1.36310705
54NFIB_24661679_ChIP-Seq_LUNG_Mouse1.35555454
55* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.34818281
56SALL4_18804426_ChIP-ChIP_XEN_Mouse1.34467461
57ESR1_21235772_ChIP-Seq_MCF-7_Human1.34153745
58SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.34040014
59SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.34040014
60STAT4_19710469_ChIP-ChIP_TH1__Mouse1.32365929
61KDM2B_26808549_Chip-Seq_K562_Human1.31547417
62GATA6_25053715_ChIP-Seq_YYC3_Human1.29198198
63GATA1_19941826_ChIP-Seq_K562_Human1.28197773
64ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.26632709
65GATA4_25053715_ChIP-Seq_YYC3_Human1.26182370
66P300_27058665_Chip-Seq_ZR-75-30cells_Human1.25381244
67KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25373887
68VDR_21846776_ChIP-Seq_THP-1_Human1.24980381
69SOX2_27498859_Chip-Seq_STOMACH_Mouse1.24366269
70TCF7_22412390_ChIP-Seq_EML_Mouse1.24330996
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23348290
72MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.22736991
73SOX9_24532713_ChIP-Seq_HFSC_Mouse1.22478593
74RACK7_27058665_Chip-Seq_MCF-7_Human1.22390530
75GATA2_21666600_ChIP-Seq_HMVEC_Human1.22023960
76SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.21946006
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20151498
78* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.17932482
79ESR2_21235772_ChIP-Seq_MCF-7_Human1.17931321
80PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17578452
81MAF_26560356_Chip-Seq_TH1_Human1.17108297
82CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.16239717
83CJUN_26792858_Chip-Seq_BT549_Human1.15976055
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15954697
85* FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.15048867
86STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14725305
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13988075
88BRD4_25478319_ChIP-Seq_HGPS_Human1.13578018
89UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13417540
90* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12781874
91FOXA2_19822575_ChIP-Seq_HepG2_Human1.11256162
92TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08890793
93SMC1_22415368_ChIP-Seq_MEFs_Mouse1.08887431
94FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.07433981
95KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07341596
96JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07153634
97TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06357869
98VDR_24787735_ChIP-Seq_THP-1_Human1.06319857
99NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05095393
100UBF1/2_26484160_Chip-Seq_HMECs_Human1.04232801
101KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02197615
102TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.01077867
103VDR_24763502_ChIP-Seq_THP-1_Human1.00773556
104* SOX2_20726797_ChIP-Seq_SW620_Human0.99336207
105EP300_21415370_ChIP-Seq_HL-1_Mouse0.99286030
106KDM2B_26808549_Chip-Seq_DND41_Human0.99158215
107UTX_26944678_Chip-Seq_JUKART_Human0.98677947
108NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.98092784
109P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97811019
110* NCOR1_26117541_ChIP-Seq_K562_Human0.97596290
111CDX2_20551321_ChIP-Seq_CACO-2_Human0.97550511
112KDM2B_26808549_Chip-Seq_JURKAT_Human0.96711586
113MYB_26560356_Chip-Seq_TH1_Human0.96036877
114TBX20_22080862_ChIP-Seq_HEART_Mouse0.95282661
115TBX20_22328084_ChIP-Seq_HEART_Mouse0.95282661
116E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.95104856
117HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94619806
118JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94229455
119* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94142555
120TFEB_21752829_ChIP-Seq_HELA_Human0.93731018
121ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.93082581
122PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92838719
123THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.89991906
124HNF4A_19822575_ChIP-Seq_HepG2_Human0.89487659
125NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.87515500

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.00668974
2MP0008438_abnormal_cutaneous_collagen3.88784883
3MP0005360_urolithiasis3.76610370
4MP0002139_abnormal_hepatobiliary_system3.15158719
5MP0003252_abnormal_bile_duct2.24517255
6MP0009840_abnormal_foam_cell2.23644009
7MP0010352_gastrointestinal_tract_polyps2.22627967
8MP0005365_abnormal_bile_salt2.17950279
9MP0005275_abnormal_skin_tensile2.16126406
10MP0003300_gastrointestinal_ulcer2.11412165
11MP0003566_abnormal_cell_adhesion2.05326564
12MP0005085_abnormal_gallbladder_physiolo2.00614292
13MP0003950_abnormal_plasma_membrane1.84050509
14MP0006054_spinal_hemorrhage1.80374184
15MP0008004_abnormal_stomach_pH1.74075011
16MP0005023_abnormal_wound_healing1.73875322
17MP0008875_abnormal_xenobiotic_pharmacok1.69108109
18MP0003279_aneurysm1.67649091
19MP0001542_abnormal_bone_strength1.58441156
20MP0010329_abnormal_lipoprotein_level1.56879374
21MP0001958_emphysema1.55822568
22MP0005058_abnormal_lysosome_morphology1.51173265
23MP0004272_abnormal_basement_membrane1.49186250
24MP0003191_abnormal_cellular_cholesterol1.42867674
25MP0005076_abnormal_cell_differentiation1.41981491
26MP0002138_abnormal_hepatobiliary_system1.41611866
27MP0001666_abnormal_nutrient_absorption1.39459053
28MP0003303_peritoneal_inflammation1.38493655
29MP0002877_abnormal_melanocyte_morpholog1.38011341
30MP0003091_abnormal_cell_migration1.37598662
31MP0002148_abnormal_hypersensitivity_rea1.36484394
32MP0003806_abnormal_nucleotide_metabolis1.34348393
33MP0003436_decreased_susceptibility_to1.32355319
34MP0003172_abnormal_lysosome_physiology1.31548533
35MP0002060_abnormal_skin_morphology1.31331227
36MP0005503_abnormal_tendon_morphology1.28888596
37MP0010234_abnormal_vibrissa_follicle1.28627077
38MP0000609_abnormal_liver_physiology1.28391107
39MP0010368_abnormal_lymphatic_system1.22671360
40MP0000604_amyloidosis1.19093509
41MP0005164_abnormal_response_to1.18657704
42MP0005409_darkened_coat_color1.17399685
43MP0009384_cardiac_valve_regurgitation1.17193853
44MP0009785_altered_susceptibility_to1.16370962
45MP0005257_abnormal_intraocular_pressure1.15745881
46MP0005332_abnormal_amino_acid1.15728592
47MP0003453_abnormal_keratinocyte_physiol1.13476200
48MP0010307_abnormal_tumor_latency1.12244430
49MP0003941_abnormal_skin_development1.11265344
50MP0003828_pulmonary_edema1.10862919
51MP0005165_increased_susceptibility_to1.10190209
52MP0003075_altered_response_to1.09521857
53MP0000733_abnormal_muscle_development1.08134355
54MP0004947_skin_inflammation1.07919123
55MP0000767_abnormal_smooth_muscle1.07854070
56MP0001835_abnormal_antigen_presentation1.07673435
57MP0003724_increased_susceptibility_to1.07618276
58MP0000685_abnormal_immune_system1.06283991
59MP0004185_abnormal_adipocyte_glucose1.06207578
60MP0002168_other_aberrant_phenotype1.03124704
61MP0005083_abnormal_biliary_tract1.03120475
62MP0009643_abnormal_urine_homeostasis1.02458892
63MP0000598_abnormal_liver_morphology1.02142240
64MP0001915_intracranial_hemorrhage1.01601649
65MP0004264_abnormal_extraembryonic_tissu1.00044591
66MP0004233_abnormal_muscle_weight0.98940738
67MP0004858_abnormal_nervous_system0.96535925
68MP0005319_abnormal_enzyme/_coenzyme0.96496073
69MP0004019_abnormal_vitamin_homeostasis0.95683519
70MP0009333_abnormal_splenocyte_physiolog0.94983843
71MP0005666_abnormal_adipose_tissue0.93934380
72MP0001243_abnormal_dermal_layer0.93815056
73MP0005000_abnormal_immune_tolerance0.92761118
74MP0001533_abnormal_skeleton_physiology0.92653256
75MP0002796_impaired_skin_barrier0.92395822
76MP0005451_abnormal_body_composition0.92220005
77MP0005595_abnormal_vascular_smooth0.91545033
78MP0003195_calcinosis0.91298452
79MP0002933_joint_inflammation0.90991740
80MP0009053_abnormal_anal_canal0.89887389
81MP0005464_abnormal_platelet_physiology0.89369294
82MP0003795_abnormal_bone_structure0.88604275
83MP0000858_altered_metastatic_potential0.87340843
84MP0002136_abnormal_kidney_physiology0.85747706
85MP0002254_reproductive_system_inflammat0.85714559
86MP0003656_abnormal_erythrocyte_physiolo0.85359649
87MP0005166_decreased_susceptibility_to0.83744652
88MP0002118_abnormal_lipid_homeostasis0.83142829
89MP0005387_immune_system_phenotype0.83082728
90MP0001790_abnormal_immune_system0.83082728
91MP0003045_fibrosis0.82846748
92MP0003448_altered_tumor_morphology0.82664793
93MP0010155_abnormal_intestine_physiology0.81918954
94MP0009278_abnormal_bone_marrow0.81436040
95MP0008260_abnormal_autophagy0.81351219
96MP0002419_abnormal_innate_immunity0.80191392
97MP0001216_abnormal_epidermal_layer0.80147073
98MP0002295_abnormal_pulmonary_circulatio0.80050176
99MP0005670_abnormal_white_adipose0.80027583
100MP0002998_abnormal_bone_remodeling0.79109273
101MP0001845_abnormal_inflammatory_respons0.76824506
102MP0006082_CNS_inflammation0.76736001
103MP0000003_abnormal_adipose_tissue0.75290592
104MP0005025_abnormal_response_to0.74625462
105MP0002896_abnormal_bone_mineralization0.73988867
106MP0005623_abnormal_meninges_morphology0.73389740
107MP0008469_abnormal_protein_level0.73214311
108MP0005395_other_phenotype0.73008157
109MP0000249_abnormal_blood_vessel0.72697561
110MP0001545_abnormal_hematopoietic_system0.72299869
111MP0005397_hematopoietic_system_phenotyp0.72299869
112MP0002452_abnormal_antigen_presenting0.72141232
113MP0009763_increased_sensitivity_to0.71794427
114MP0003186_abnormal_redox_activity0.71668915
115MP0002166_altered_tumor_susceptibility0.71520571
116MP0000343_altered_response_to0.71510861
117MP0002128_abnormal_blood_circulation0.71415703
118MP0001853_heart_inflammation0.71384972
119MP0005375_adipose_tissue_phenotype0.71214786
120MP0004510_myositis0.70669154
121MP0000678_abnormal_parathyroid_gland0.70124386
122MP0001879_abnormal_lymphatic_vessel0.69993930
123MP0005390_skeleton_phenotype0.69666180
124MP0001756_abnormal_urination0.69090678
125MP0001849_ear_inflammation0.68747121
126MP0009764_decreased_sensitivity_to0.68555179
127MP0005508_abnormal_skeleton_morphology0.67935336
128MP0001800_abnormal_humoral_immune0.67663898
129MP0005167_abnormal_blood-brain_barrier0.67390522
130MP0002135_abnormal_kidney_morphology0.66539778
131MP0000371_diluted_coat_color0.65501138
132MP0003868_abnormal_feces_composition0.64964071
133MP0002113_abnormal_skeleton_development0.64409131

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.92238474
2Premature rupture of membranes (HP:0001788)4.37603229
3Abnormality of glycolipid metabolism (HP:0010969)4.01323762
4Abnormality of liposaccharide metabolism (HP:0010968)4.01323762
5Abnormality of glycosphingolipid metabolism (HP:0004343)4.01323762
6Deep venous thrombosis (HP:0002625)3.84174773
7Peritonitis (HP:0002586)3.66447876
8Myocardial infarction (HP:0001658)3.58310514
9Xanthomatosis (HP:0000991)3.33904534
10Ankle contracture (HP:0006466)3.29903438
11Cerebral aneurysm (HP:0004944)3.24420301
12Cervical subluxation (HP:0003308)3.23423285
13Aortic dissection (HP:0002647)3.06443903
14Vascular tortuosity (HP:0004948)3.05372374
15Aortic aneurysm (HP:0004942)3.05240805
16Dysostosis multiplex (HP:0000943)3.01493949
17Abnormality of glutamine family amino acid metabolism (HP:0010902)2.99839198
18Abnormality of monocarboxylic acid metabolism (HP:0010996)2.80574471
19Arterial tortuosity (HP:0005116)2.78287117
20Spinal rigidity (HP:0003306)2.74452833
21Mitral valve prolapse (HP:0001634)2.74036964
22Follicular hyperkeratosis (HP:0007502)2.73728458
23Intrahepatic cholestasis (HP:0001406)2.71914677
24Increased connective tissue (HP:0009025)2.66964704
25Shallow orbits (HP:0000586)2.65442145
26Osteolytic defects of the phalanges of the hand (HP:0009771)2.62560057
27Osteolytic defects of the hand bones (HP:0009699)2.62560057
28Complement deficiency (HP:0004431)2.47488527
29Increased mean platelet volume (HP:0011877)2.47439418
30Hypobetalipoproteinemia (HP:0003563)2.47124559
31Dilatation of the ascending aorta (HP:0005111)2.45650251
32Esophageal varix (HP:0002040)2.44842876
33Abnormality of polysaccharide metabolism (HP:0011012)2.44499897
34Abnormality of glycosaminoglycan metabolism (HP:0004371)2.44499897
35Abnormality of mucopolysaccharide metabolism (HP:0011020)2.44499897
36Vertebral compression fractures (HP:0002953)2.43190675
37Hypoalphalipoproteinemia (HP:0003233)2.42207719
38Aneurysm (HP:0002617)2.37813506
39Hypolipoproteinemia (HP:0010981)2.37121331
40Abnormality of the common coagulation pathway (HP:0010990)2.36013228
41Nuclear cataract (HP:0100018)2.32281720
42Atrophic scars (HP:0001075)2.31721224
43Abnormality of proline metabolism (HP:0010907)2.30893486
44Hydroxyprolinuria (HP:0003080)2.30893486
45Abnormal platelet volume (HP:0011876)2.28329353
46Thin bony cortex (HP:0002753)2.27439584
47Ulnar bowing (HP:0003031)2.26805368
48Axonal loss (HP:0003447)2.24922999
49Blue sclerae (HP:0000592)2.24827813
50Slender build (HP:0001533)2.24662819
51Hematochezia (HP:0002573)2.20828548
52Increased variability in muscle fiber diameter (HP:0003557)2.19718091
53Neurofibrillary tangles (HP:0002185)2.18460741
54Achilles tendon contracture (HP:0001771)2.18431116
55Abnormality of complement system (HP:0005339)2.16570376
56Camptodactyly of toe (HP:0001836)2.15585462
57Systemic lupus erythematosus (HP:0002725)2.13984534
58Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.12469739
59Genu recurvatum (HP:0002816)2.12317371
60Autoimmune thrombocytopenia (HP:0001973)2.12057406
61Mitral stenosis (HP:0001718)2.11173500
62Biconcave vertebral bodies (HP:0004586)2.10686066
63Broad metatarsal (HP:0001783)2.10123211
64Abnormality of the Achilles tendon (HP:0005109)2.09334435
65Soft skin (HP:0000977)2.08384264
66Abnormality of aromatic amino acid family metabolism (HP:0004338)2.08363264
67Asymmetric septal hypertrophy (HP:0001670)2.07772585
68Elbow flexion contracture (HP:0002987)2.07451059
69Right ventricular cardiomyopathy (HP:0011663)2.06617917
70Mildly elevated creatine phosphokinase (HP:0008180)2.06362673
71Abnormality of sulfur amino acid metabolism (HP:0004339)2.03026800
72Ovoid vertebral bodies (HP:0003300)2.02742222
73Distal lower limb amyotrophy (HP:0008944)2.01882872
74Joint laxity (HP:0001388)1.99698718
75Skin nodule (HP:0200036)1.99649791
76Nephritis (HP:0000123)1.99537367
77Epidermoid cyst (HP:0200040)1.99532338
78Segmental peripheral demyelination/remyelination (HP:0003481)1.99501604
79Abnormal cartilage morphology (HP:0002763)1.99384880
80Recurrent gram-negative bacterial infections (HP:0005420)1.98690469
81Polycythemia (HP:0001901)1.98506887
82Joint stiffness (HP:0001387)1.98194311
83Persistence of primary teeth (HP:0006335)1.98153594
84Natal tooth (HP:0000695)1.97108970
85Loss of speech (HP:0002371)1.97004200
86Neonatal short-limb short stature (HP:0008921)1.95355353
87Abnormality of skeletal muscle fiber size (HP:0012084)1.94922301
88Mitral regurgitation (HP:0001653)1.93923108
89Spondylolisthesis (HP:0003302)1.92867520
90Cerebral inclusion bodies (HP:0100314)1.92112580
91Hypoglycemic coma (HP:0001325)1.91314487
92Cardiovascular calcification (HP:0011915)1.91172912
93Increased density of long bones (HP:0006392)1.91137022
94Disproportionate tall stature (HP:0001519)1.90994917
95Subacute progressive viral hepatitis (HP:0006572)1.90794585
96Syringomyelia (HP:0003396)1.90405220
97Spinal cord lesions (HP:0100561)1.90405220
98Hyperammonemia (HP:0001987)1.90325661
99Hepatocellular carcinoma (HP:0001402)1.88814488
100Flared iliac wings (HP:0002869)1.88529472
101Abnormal delivery (HP:0001787)1.88187465
102Fragile skin (HP:0001030)1.88070756
103Hyperextensible skin (HP:0000974)1.87740433
104Abnormality of the intrinsic pathway (HP:0010989)1.87392039
105Overgrowth (HP:0001548)1.87220565
106Abnormality of the acetabulum (HP:0003170)1.86251189
107Nonimmune hydrops fetalis (HP:0001790)1.85267122
108Wormian bones (HP:0002645)1.84819095
109Aortic regurgitation (HP:0001659)1.84552801
110Tibial bowing (HP:0002982)1.83845283
111Tetraparesis (HP:0002273)1.83582437
112Abnormality of the vasculature of the conjunctiva (HP:0008054)1.82889061
113Abnormality of the peritoneum (HP:0002585)1.81813678
114Abnormality of purine metabolism (HP:0004352)1.80938885
115Ectopia lentis (HP:0001083)1.80631273
116Chondrocalcinosis (HP:0000934)1.79976516
117Hypercholesterolemia (HP:0003124)1.79618352
118Wrist flexion contracture (HP:0001239)1.78971491
119Emphysema (HP:0002097)1.78456559
120Long toe (HP:0010511)1.78139568
121Joint hemorrhage (HP:0005261)1.77452374
122Bone pain (HP:0002653)1.76602265
123Lymphangioma (HP:0100764)1.76586616
124Type 1 muscle fiber predominance (HP:0003803)1.76459433
125Striae distensae (HP:0001065)1.76226797
126Urinary glycosaminoglycan excretion (HP:0003541)1.75700697
127Mucopolysacchariduria (HP:0008155)1.75700697
128Abnormality of macrophages (HP:0004311)1.75289389
129Short nail (HP:0001799)1.74518669
130Bladder diverticulum (HP:0000015)1.73059169
131Eczematoid dermatitis (HP:0000976)1.72816680
132Glomerulonephritis (HP:0000099)1.72455135
133Vacuolated lymphocytes (HP:0001922)1.72424700
134Hyperparathyroidism (HP:0000843)1.72104395
135Thoracolumbar scoliosis (HP:0002944)1.71130196
136Hyperlipoproteinemia (HP:0010980)1.70455364
137Malnutrition (HP:0004395)1.69601788
138Upper limb amyotrophy (HP:0009129)1.69574509
139Distal upper limb amyotrophy (HP:0007149)1.69574509
140Focal segmental glomerulosclerosis (HP:0000097)1.69289053
141Spastic diplegia (HP:0001264)1.68348088
142Hemorrhage of the eye (HP:0011885)1.67463817
143Impaired platelet aggregation (HP:0003540)1.67343003
144Abnormal platelet function (HP:0011869)1.67343003
145Fat malabsorption (HP:0002630)1.67259256
146Bowed forearm bones (HP:0003956)1.66509098
147Bowing of the arm (HP:0006488)1.66509098
148Abnormality of dentin (HP:0010299)1.65969159
149Alopecia of scalp (HP:0002293)1.65563945
150Aortic valve stenosis (HP:0001650)1.64547516
151Distal lower limb muscle weakness (HP:0009053)1.60111082
152Conjunctival telangiectasia (HP:0000524)1.59588205

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.15499809
2ERN13.33282465
3PKN23.16897353
4LATS13.01438513
5PRPF4B2.48211245
6TTN2.47642658
7RIPK12.18101191
8TAOK22.06421584
9MAP3K102.03452462
10EEF2K2.01660500
11SIK12.00247109
12PTK61.99315609
13PDGFRA1.98874059
14MYLK1.95581802
15STK101.89626109
16LRRK21.89493914
17STK31.81927849
18DDR21.75645318
19CDC42BPA1.74519098
20NEK91.69218274
21FRK1.68292261
22TAOK31.66292789
23FGFR41.48164220
24TYK21.47577903
25TBK11.46786389
26RPS6KA41.44648731
27JAK31.42909769
28FLT31.42057819
29TGFBR21.39898441
30BMX1.37767969
31ICK1.37628002
32CDK121.31678785
33LATS21.30686982
34TRPM71.22488598
35PTK21.19304314
36MAP2K31.18501858
37MAP3K11.16341835
38MAP4K11.16039913
39JAK11.15280864
40CAMK1D1.12945586
41EPHB11.12859278
42GRK71.12498561
43MST1R1.12041426
44PAK41.09008816
45CDK61.08250414
46ERBB41.06061644
47MAP3K141.05791844
48EPHA21.05285643
49MAP3K81.04824380
50BMPR21.03782895
51PAK21.01491931
52STK38L1.01214140
53TYRO31.00743284
54KIT0.95983330
55PDK20.95979895
56AKT30.94111390
57STK240.91658216
58MAP3K20.91325258
59SCYL20.91193102
60BCKDK0.90600222
61ARAF0.90207083
62NTRK10.89954642
63MAP3K30.89691115
64PDGFRB0.89169147
65CSF1R0.89118787
66NEK20.87969326
67MTOR0.87559013
68MOS0.87338822
69MET0.86514241
70CSK0.86016990
71CHUK0.84172360
72CLK10.81968612
73MATK0.80306331
74ABL20.76422293
75EPHB20.75183624
76TAOK10.73829849
77FGR0.71801087
78DMPK0.67741376
79PIM10.67611177
80EPHA30.67149932
81FGFR30.66613871
82KDR0.65120035
83PIK3CG0.64672206
84IKBKB0.64614481
85CDK40.63600814
86JAK20.63022475
87NUAK10.62843030
88MAPK110.61832133
89ZAP700.60889456
90PDPK10.60430461
91PRKG20.60317302
92SMG10.59189094
93CAMK1G0.58454451
94TGFBR10.58409026
95PIM20.57442973
96RET0.56992801
97TIE10.56795455
98BLK0.55393406
99IRAK20.55373505
100PRKD20.54994388
101MAPK70.54519679
102NME20.53524114
103MAP3K130.52176719
104MAP2K10.51358181
105IRAK10.50957303
106IRAK30.50824010
107PRKAA20.50362054
108MAP3K60.50316398
109GRK60.50186398
110MELK0.49149508
111ABL10.48928997
112KSR20.48056408
113WNK10.47727593
114RPS6KA20.47030034
115TESK10.44841811
116TTK0.44446970
117MAPKAPK30.44149503
118CDK90.44047323
119RPS6KB20.43473254
120GSK3A0.41190595
121MARK20.40937563
122STK40.40674575
123MAP3K110.40391478
124EGFR0.40238342
125MAP3K50.39726504
126DYRK1B0.38767577
127BTK0.38449092
128ILK0.38228876
129MARK30.38029728
130STK380.36979390
131IKBKE0.36908747
132HCK0.36837706
133DAPK30.35386808
134IRAK40.34764797
135BRAF0.34332385

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.83077187
2Nitrogen metabolism_Homo sapiens_hsa009102.39387862
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.38465155
4Caffeine metabolism_Homo sapiens_hsa002322.31485748
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.30207963
6Complement and coagulation cascades_Homo sapiens_hsa046102.09409970
7Arginine biosynthesis_Homo sapiens_hsa002201.95761379
8Pentose and glucuronate interconversions_Homo sapiens_hsa000401.91821127
9Fatty acid degradation_Homo sapiens_hsa000711.91005389
10Prion diseases_Homo sapiens_hsa050201.84816516
11Tryptophan metabolism_Homo sapiens_hsa003801.80065551
12PPAR signaling pathway_Homo sapiens_hsa033201.77514242
13Staphylococcus aureus infection_Homo sapiens_hsa051501.70422442
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.48010666
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45651167
16Fat digestion and absorption_Homo sapiens_hsa049751.44765023
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44257480
18Salmonella infection_Homo sapiens_hsa051321.43110819
19Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.40064111
20Starch and sucrose metabolism_Homo sapiens_hsa005001.35712176
21Rheumatoid arthritis_Homo sapiens_hsa053231.34697386
22Selenocompound metabolism_Homo sapiens_hsa004501.30203387
23ECM-receptor interaction_Homo sapiens_hsa045121.26519013
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.21997510
25Lysine degradation_Homo sapiens_hsa003101.20537247
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19259424
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.18470370
28Small cell lung cancer_Homo sapiens_hsa052221.17036064
29Fatty acid metabolism_Homo sapiens_hsa012121.15839784
30Hepatitis C_Homo sapiens_hsa051601.15340595
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10682333
32Influenza A_Homo sapiens_hsa051641.09950443
33Peroxisome_Homo sapiens_hsa041461.08499666
34Focal adhesion_Homo sapiens_hsa045101.07699356
35Bile secretion_Homo sapiens_hsa049761.06937653
36Histidine metabolism_Homo sapiens_hsa003401.06402395
37African trypanosomiasis_Homo sapiens_hsa051431.06328583
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.05811859
39Chemical carcinogenesis_Homo sapiens_hsa052041.04989926
40Renal cell carcinoma_Homo sapiens_hsa052111.04922292
41Amoebiasis_Homo sapiens_hsa051461.04326513
42VEGF signaling pathway_Homo sapiens_hsa043701.04173725
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.03138137
44Leishmaniasis_Homo sapiens_hsa051401.02416712
45Chronic myeloid leukemia_Homo sapiens_hsa052201.02239039
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02200489
47Vitamin digestion and absorption_Homo sapiens_hsa049771.02084607
48beta-Alanine metabolism_Homo sapiens_hsa004101.01848568
49Propanoate metabolism_Homo sapiens_hsa006401.00833275
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99941234
51Bladder cancer_Homo sapiens_hsa052190.99311209
52Renin-angiotensin system_Homo sapiens_hsa046140.97135808
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97026800
54Sphingolipid metabolism_Homo sapiens_hsa006000.96695099
55Prolactin signaling pathway_Homo sapiens_hsa049170.95598578
56Proteoglycans in cancer_Homo sapiens_hsa052050.94705027
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94224846
58Adherens junction_Homo sapiens_hsa045200.93781089
59Carbon metabolism_Homo sapiens_hsa012000.92075072
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91584170
61Biosynthesis of amino acids_Homo sapiens_hsa012300.90880665
62Toxoplasmosis_Homo sapiens_hsa051450.89091431
63Insulin resistance_Homo sapiens_hsa049310.88114270
64Pancreatic cancer_Homo sapiens_hsa052120.86906365
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86008619
66One carbon pool by folate_Homo sapiens_hsa006700.85659577
67Malaria_Homo sapiens_hsa051440.84804496
68Jak-STAT signaling pathway_Homo sapiens_hsa046300.84778711
69Measles_Homo sapiens_hsa051620.83516507
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83459413
71Prostate cancer_Homo sapiens_hsa052150.83238596
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82684293
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.82648887
74Osteoclast differentiation_Homo sapiens_hsa043800.82200468
75Thyroid cancer_Homo sapiens_hsa052160.81813603
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.81033219
77Phagosome_Homo sapiens_hsa041450.79519461
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.79389433
79Lysosome_Homo sapiens_hsa041420.78983318
80HIF-1 signaling pathway_Homo sapiens_hsa040660.78722327
81MicroRNAs in cancer_Homo sapiens_hsa052060.77258574
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.77235819
83Protein digestion and absorption_Homo sapiens_hsa049740.77110284
84Folate biosynthesis_Homo sapiens_hsa007900.76942274
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.76893579
86Retinol metabolism_Homo sapiens_hsa008300.76569137
87Phenylalanine metabolism_Homo sapiens_hsa003600.76565489
88TNF signaling pathway_Homo sapiens_hsa046680.76022448
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74476817
90Pentose phosphate pathway_Homo sapiens_hsa000300.74261147
91Apoptosis_Homo sapiens_hsa042100.73184440
92mTOR signaling pathway_Homo sapiens_hsa041500.72879978
93Shigellosis_Homo sapiens_hsa051310.72477351
94Fructose and mannose metabolism_Homo sapiens_hsa000510.71741362
95Sulfur metabolism_Homo sapiens_hsa009200.71475818
96Mineral absorption_Homo sapiens_hsa049780.71127685
97Pyruvate metabolism_Homo sapiens_hsa006200.70747536
98Other glycan degradation_Homo sapiens_hsa005110.70407829
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.70092240
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70074597
101Legionellosis_Homo sapiens_hsa051340.69874152
102Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68698539
103Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68565880
104Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68561750
105Butanoate metabolism_Homo sapiens_hsa006500.67935097
106B cell receptor signaling pathway_Homo sapiens_hsa046620.67332587
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66083959
108Vibrio cholerae infection_Homo sapiens_hsa051100.65864257
109Chemokine signaling pathway_Homo sapiens_hsa040620.65817802
110Antigen processing and presentation_Homo sapiens_hsa046120.65167892
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.65003686
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64447442
113p53 signaling pathway_Homo sapiens_hsa041150.63300752
114Galactose metabolism_Homo sapiens_hsa000520.63286849
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62706812
116ErbB signaling pathway_Homo sapiens_hsa040120.62395837
117Hematopoietic cell lineage_Homo sapiens_hsa046400.62074296
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60430348
119Glycerolipid metabolism_Homo sapiens_hsa005610.60357130
120Endocytosis_Homo sapiens_hsa041440.60275213
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59925516
122T cell receptor signaling pathway_Homo sapiens_hsa046600.59809867
123Tuberculosis_Homo sapiens_hsa051520.59466195
124Arginine and proline metabolism_Homo sapiens_hsa003300.59213306
125Glutathione metabolism_Homo sapiens_hsa004800.58754639
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58706245
127ABC transporters_Homo sapiens_hsa020100.58286135
128Non-small cell lung cancer_Homo sapiens_hsa052230.57858056
129Insulin signaling pathway_Homo sapiens_hsa049100.57173438
130Endometrial cancer_Homo sapiens_hsa052130.56964445
131Herpes simplex infection_Homo sapiens_hsa051680.56822466
132Glioma_Homo sapiens_hsa052140.56496962
133HTLV-I infection_Homo sapiens_hsa051660.56196249
134Pertussis_Homo sapiens_hsa051330.54147296
135Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53949348
136GnRH signaling pathway_Homo sapiens_hsa049120.53490096
137Acute myeloid leukemia_Homo sapiens_hsa052210.53060782
138Cysteine and methionine metabolism_Homo sapiens_hsa002700.52843411
139TGF-beta signaling pathway_Homo sapiens_hsa043500.51641818
140Pathways in cancer_Homo sapiens_hsa052000.51033210
141Notch signaling pathway_Homo sapiens_hsa043300.50286437
142FoxO signaling pathway_Homo sapiens_hsa040680.49307690
143Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47873220
144Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47549615
145Cyanoamino acid metabolism_Homo sapiens_hsa004600.47450619
146Viral carcinogenesis_Homo sapiens_hsa052030.47433570
147Hepatitis B_Homo sapiens_hsa051610.47405764
148Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46431033
149Central carbon metabolism in cancer_Homo sapiens_hsa052300.46187138
150Type II diabetes mellitus_Homo sapiens_hsa049300.46185670
151Viral myocarditis_Homo sapiens_hsa054160.45273639
152Melanoma_Homo sapiens_hsa052180.45103168
153Tyrosine metabolism_Homo sapiens_hsa003500.44778774

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