SOAT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the acyltransferase family. It is located in the endoplasmic reticulum, and catalyzes the formation of fatty acid-cholesterol esters. This gene has been implicated in the formation of beta-amyloid and atherosclerotic plaques by controlling the equilibrium between free cholesterol and cytoplasmic cholesteryl esters. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.86529720
2positive regulation by organism of defense response of other organism involved in symbiotic interact5.86529720
3modulation by symbiont of host immune response (GO:0052553)5.86529720
4positive regulation by symbiont of host defense response (GO:0052509)5.86529720
5modulation by symbiont of host defense response (GO:0052031)5.86529720
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.86529720
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.66386835
8neutrophil activation involved in immune response (GO:0002283)5.14289841
9oligosaccharide catabolic process (GO:0009313)5.13286060
10regulation of interferon-beta biosynthetic process (GO:0045357)4.67545877
11iron ion import (GO:0097286)4.14056130
12ceramide catabolic process (GO:0046514)4.10365855
13macrophage activation involved in immune response (GO:0002281)4.10172634
14glucocorticoid biosynthetic process (GO:0006704)3.97437192
15positive regulation of interferon-alpha production (GO:0032727)3.95928258
16positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.91569534
17C21-steroid hormone biosynthetic process (GO:0006700)3.83194995
18response to peptidoglycan (GO:0032494)3.73902262
19regulation of interferon-alpha production (GO:0032647)3.73242259
20wound healing, spreading of epidermal cells (GO:0035313)3.71638091
21protein localization to endosome (GO:0036010)3.70261129
22response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.70038259
23response to host immune response (GO:0052572)3.70038259
24immunoglobulin mediated immune response (GO:0016064)3.66232684
25amino sugar catabolic process (GO:0046348)3.63594306
26microglial cell activation (GO:0001774)3.62127938
27respiratory burst (GO:0045730)3.61398162
28negative regulation of interleukin-12 production (GO:0032695)3.59978642
29neutrophil activation (GO:0042119)3.50950622
30estrogen biosynthetic process (GO:0006703)3.47696032
31granulocyte activation (GO:0036230)3.47627676
32progesterone metabolic process (GO:0042448)3.40447634
33pinocytosis (GO:0006907)3.39196949
34cellular response to interferon-alpha (GO:0035457)3.38855505
35response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.38297899
36response to host (GO:0075136)3.38297899
37response to host defenses (GO:0052200)3.38297899
38negative regulation of mast cell activation (GO:0033004)3.38101689
39natural killer cell mediated cytotoxicity (GO:0042267)3.35743115
40natural killer cell mediated immunity (GO:0002228)3.35743115
41keratan sulfate catabolic process (GO:0042340)3.31882759
42membrane lipid catabolic process (GO:0046466)3.29052055
43sphingolipid catabolic process (GO:0030149)3.27776386
44phagocytosis, recognition (GO:0006910)3.24854843
45glucocorticoid metabolic process (GO:0008211)3.23527143
46regulation of mononuclear cell migration (GO:0071675)3.20810385
47myeloid cell activation involved in immune response (GO:0002275)3.17234502
48positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.15679206
49low-density lipoprotein particle clearance (GO:0034383)3.15614962
50positive regulation of cellular amide metabolic process (GO:0034250)3.11335002
51response to lipoprotein particle (GO:0055094)3.10585957
52negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.10283899
53negative regulation of cell killing (GO:0031342)3.10283899
54macrophage activation (GO:0042116)3.10214063
55osteoclast differentiation (GO:0030316)3.09372266
56regulation of B cell receptor signaling pathway (GO:0050855)3.09079228
57production of molecular mediator involved in inflammatory response (GO:0002532)3.06678324
58I-kappaB phosphorylation (GO:0007252)3.06006979
59detection of external biotic stimulus (GO:0098581)2.98751807
60detection of molecule of bacterial origin (GO:0032490)2.98262330
61regulation of mast cell degranulation (GO:0043304)2.97834478
62positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.94987755
63peptide catabolic process (GO:0043171)2.94726761
64B cell mediated immunity (GO:0019724)2.93686843
65superoxide anion generation (GO:0042554)2.93230704
66positive regulation of macrophage differentiation (GO:0045651)2.92630212
67sphingosine metabolic process (GO:0006670)2.91821123
68positive regulation of interferon-beta production (GO:0032728)2.91602662
69regulation of mast cell activation (GO:0033003)2.91020927
70negative regulation of lipid storage (GO:0010888)2.87320053
71cellular response to cadmium ion (GO:0071276)2.87031123
72response to muramyl dipeptide (GO:0032495)2.86624807
73wound healing, spreading of cells (GO:0044319)2.85868926
74leukocyte mediated cytotoxicity (GO:0001909)2.85758000
75regulation of mast cell activation involved in immune response (GO:0033006)2.85392480
76positive regulation of antigen processing and presentation (GO:0002579)2.85335491
77N-acetylneuraminate metabolic process (GO:0006054)2.83475873
78positive regulation of mast cell activation (GO:0033005)2.82708998
79antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.81164514
80neutrophil mediated immunity (GO:0002446)2.80885854
81negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.78234281
82apoptotic cell clearance (GO:0043277)2.77327234
83antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.76451580
84membrane raft organization (GO:0031579)2.75454761
85response to thyroid hormone (GO:0097066)2.75375576
86C21-steroid hormone metabolic process (GO:0008207)2.74168342
87cellular response to zinc ion (GO:0071294)2.73509126
88regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.72878535
89positive regulation of monocyte chemotaxis (GO:0090026)2.71360607
90lipopolysaccharide-mediated signaling pathway (GO:0031663)2.70751496
91glycosphingolipid catabolic process (GO:0046479)2.70417391
92T-helper 1 type immune response (GO:0042088)2.70267679
93response to interferon-alpha (GO:0035455)2.69949171
94cellular extravasation (GO:0045123)2.68822361
95cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.67999553
96negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.67988998
97cellular response to thyroid hormone stimulus (GO:0097067)2.66846941
98phagocytosis, engulfment (GO:0006911)2.65287954
99regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.64731645
100positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.63662617
101positive regulation of chemokine biosynthetic process (GO:0045080)2.63172211
102pyrimidine-containing compound transmembrane transport (GO:0072531)2.62726796
103adhesion of symbiont to host (GO:0044406)2.59185217
104response to follicle-stimulating hormone (GO:0032354)2.58958433
105Arp2/3 complex-mediated actin nucleation (GO:0034314)2.58479785
106cellular response to antibiotic (GO:0071236)2.57613208
107hyaluronan catabolic process (GO:0030214)2.57399728
108regulation of leukocyte degranulation (GO:0043300)2.57143251
109eosinophil chemotaxis (GO:0048245)2.56743618
110myeloid cell homeostasis (GO:0002262)2.56002595
111detection of other organism (GO:0098543)2.54319459
112antigen processing and presentation of endogenous antigen (GO:0019883)2.54238672
113regulation of antigen processing and presentation (GO:0002577)2.54143639
114cytokine metabolic process (GO:0042107)2.53437701
115detection of biotic stimulus (GO:0009595)2.52467455
116diol metabolic process (GO:0034311)2.51468555
117positive regulation of macrophage cytokine production (GO:0060907)2.51296782
118surfactant homeostasis (GO:0043129)2.50978046
119regulation of interleukin-8 biosynthetic process (GO:0045414)2.50182845
120positive regulation of mast cell activation involved in immune response (GO:0033008)2.49665257
121positive regulation of mast cell degranulation (GO:0043306)2.49665257
122myeloid leukocyte activation (GO:0002274)2.49483145
123negative regulation of nitric oxide biosynthetic process (GO:0045019)2.49143968
124positive regulation of leukocyte degranulation (GO:0043302)2.46672288
125regulation of dendritic cell antigen processing and presentation (GO:0002604)2.46580778
126regulation of transforming growth factor beta1 production (GO:0032908)2.46369733
127lymphocyte mediated immunity (GO:0002449)2.45248175
128sphingoid metabolic process (GO:0046519)2.44690572
129cell adhesion mediated by integrin (GO:0033627)2.44518443
130positive regulation of hormone biosynthetic process (GO:0046886)2.43147966
131positive regulation of interleukin-6 production (GO:0032755)2.43132281
132cellular response to ethanol (GO:0071361)2.42913876
133positive regulation of chemokine production (GO:0032722)2.42372937
134regulation of monocyte chemotaxis (GO:0090025)2.41954872
135negative regulation of interleukin-17 production (GO:0032700)2.41793623
136leukocyte aggregation (GO:0070486)2.40119662
137intracellular pH reduction (GO:0051452)2.39077248
138glycolipid catabolic process (GO:0019377)2.37430580
139vitamin D metabolic process (GO:0042359)2.37145388
140positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.37089532
141myeloid dendritic cell differentiation (GO:0043011)2.36980153
142regulation of interferon-gamma biosynthetic process (GO:0045072)2.36979712
143regulation of cholesterol storage (GO:0010885)2.36488007
144glucosamine-containing compound catabolic process (GO:1901072)2.36418561
145intracellular lipid transport (GO:0032365)2.36128485
146positive regulation of gamma-delta T cell activation (GO:0046645)2.35979135
147myeloid dendritic cell activation (GO:0001773)2.34275581
148regulation of macrophage derived foam cell differentiation (GO:0010743)2.33619046
149plasma lipoprotein particle clearance (GO:0034381)2.33254944
150regulation of vitamin D biosynthetic process (GO:0060556)2.33108177
151cellular response to gonadotropin stimulus (GO:0071371)2.33009129
152regulation of myeloid leukocyte mediated immunity (GO:0002886)2.30870832
153hydrogen peroxide biosynthetic process (GO:0050665)2.30835908
154positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.30311000
155androgen biosynthetic process (GO:0006702)2.29817056
156adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.26587744
157positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.25110817

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.68613557
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.01933425
3E2F7_22180533_ChIP-Seq_HELA_Human4.98043525
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.81378831
5EGR1_19374776_ChIP-ChIP_THP-1_Human4.27606353
6* IRF8_27001747_Chip-Seq_BMDM_Mouse3.78414678
7* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.62790752
8* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.60777352
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.35731290
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.17631840
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.97277584
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.89730620
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.80249312
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.74008948
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.62749699
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.57599107
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.41420732
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.38963756
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.35397950
20TP63_17297297_ChIP-ChIP_HaCaT_Human2.31690693
21SMAD_19615063_ChIP-ChIP_OVARY_Human2.31311244
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.25280545
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.18341131
24SPI1_23547873_ChIP-Seq_NB4_Human2.14001816
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.13817556
26* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.12036874
27ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.11856558
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.02924387
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.94368182
30STAT4_19710469_ChIP-ChIP_TH1__Mouse1.91592630
31* PU_27001747_Chip-Seq_BMDM_Mouse1.71458082
32GATA1_22025678_ChIP-Seq_K562_Human1.68877080
33MYB_26560356_Chip-Seq_TH2_Human1.67711794
34SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.66643574
35TFEB_21752829_ChIP-Seq_HELA_Human1.66232700
36VDR_24763502_ChIP-Seq_THP-1_Human1.64494169
37VDR_24787735_ChIP-Seq_THP-1_Human1.62200583
38TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.60957430
39E2F4_17652178_ChIP-ChIP_JURKAT_Human1.58768158
40SPI1_23127762_ChIP-Seq_K562_Human1.55032999
41* RUNX1_22412390_ChIP-Seq_EML_Mouse1.54491286
42* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.49311393
43PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.47760494
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.47641508
45LXR_22158963_ChIP-Seq_LIVER_Mouse1.46666771
46* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.43316122
47CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.38360039
48* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.37153032
49* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.37153032
50CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36539046
51ELK1_19687146_ChIP-ChIP_HELA_Human1.35534522
52HIF1A_21447827_ChIP-Seq_MCF-7_Human1.34069268
53JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33494393
54STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30188548
55CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.29900355
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28273781
57PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26623240
58* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24518619
59* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24518619
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24440868
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23428637
62VDR_21846776_ChIP-Seq_THP-1_Human1.23243655
63MYB_26560356_Chip-Seq_TH1_Human1.22352540
64* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.21501649
65SCL_19346495_ChIP-Seq_HPC-7_Human1.20650747
66FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.19983409
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.19492630
68TRIM28_21343339_ChIP-Seq_HEK293_Human1.19470850
69NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15972154
70* MAF_26560356_Chip-Seq_TH1_Human1.15409883
71BRD4_25478319_ChIP-Seq_HGPS_Human1.14448393
72RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.14424922
73STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14180991
74TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13461652
75FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12764644
76SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12643117
77* E2F1_21310950_ChIP-Seq_MCF-7_Human1.11132998
78ESR1_21235772_ChIP-Seq_MCF-7_Human1.10135534
79* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09165609
80CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08821579
81TP63_23658742_ChIP-Seq_EP156T_Human1.07634250
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05974191
83GATA3_27048872_Chip-Seq_THYMUS_Human1.05455338
84GATA2_21666600_ChIP-Seq_HMVEC_Human1.05103643
85RUNX_20019798_ChIP-Seq_JUKART_Human1.04770201
86CJUN_26792858_Chip-Seq_BT549_Human1.04199779
87HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04185670
88RXR_22158963_ChIP-Seq_LIVER_Mouse1.03660984
89PPARA_22158963_ChIP-Seq_LIVER_Mouse1.03615859
90CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99387306
91VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98955094
92CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98267047
93RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97450824
94PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.95803955
95* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95328198
96TP53_16413492_ChIP-PET_HCT116_Human0.94661643
97TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.94315354
98FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94087387
99* GATA4_25053715_ChIP-Seq_YYC3_Human0.93827007
100CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92062322
101PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91813928
102SALL1_21062744_ChIP-ChIP_HESCs_Human0.91435034
103AR_21909140_ChIP-Seq_LNCAP_Human0.91135038
104SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90246321
105ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.89833736
106* SOX2_20726797_ChIP-Seq_SW620_Human0.88796147
107* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87943641
108* GATA3_26560356_Chip-Seq_TH2_Human0.87845265
109* UTX_26944678_Chip-Seq_JUKART_Human0.86924589
110NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.86580978
111GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86202329
112CLOCK_20551151_ChIP-Seq_293T_Human0.84819665
113LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.84730652
114AHR_22903824_ChIP-Seq_MCF-7_Human0.84490375
115NOTCH1_21737748_ChIP-Seq_TLL_Human0.83424799
116EGR1_23403033_ChIP-Seq_LIVER_Mouse0.83391053
117ERG_20887958_ChIP-Seq_HPC-7_Mouse0.83340945
118* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83338470
119ELF1_17652178_ChIP-ChIP_JURKAT_Human0.83291776
120FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83273758
121* UBF1/2_26484160_Chip-Seq_HMECs_Human0.83139989
122FOXO3_23340844_ChIP-Seq_DLD1_Human0.81696229
123JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81083206
124SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80440454
125* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80365444
126ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.79373610
127* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.77684767

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.57695783
2MP0009840_abnormal_foam_cell3.45740759
3MP0000569_abnormal_digit_pigmentation3.34065347
4MP0001835_abnormal_antigen_presentation3.14910200
5MP0003436_decreased_susceptibility_to2.74928458
6MP0002419_abnormal_innate_immunity2.48464223
7MP0003172_abnormal_lysosome_physiology2.43381768
8MP0000604_amyloidosis2.30424935
9MP0003303_peritoneal_inflammation2.29166927
10MP0001958_emphysema2.27163838
11MP0008438_abnormal_cutaneous_collagen2.26069197
12MP0004782_abnormal_surfactant_physiolog2.24832564
13MP0005257_abnormal_intraocular_pressure2.22205708
14MP0002148_abnormal_hypersensitivity_rea2.15746764
15MP0005174_abnormal_tail_pigmentation2.11711248
16MP0006082_CNS_inflammation2.09246504
17MP0005000_abnormal_immune_tolerance2.07677351
18MP0010234_abnormal_vibrissa_follicle1.99206856
19MP0002452_abnormal_antigen_presenting1.96312209
20MP0010307_abnormal_tumor_latency1.94949784
21MP0003950_abnormal_plasma_membrane1.82055907
22MP0009785_altered_susceptibility_to1.81915383
23MP0005025_abnormal_response_to1.79521210
24MP0003448_altered_tumor_morphology1.74974200
25MP0003806_abnormal_nucleotide_metabolis1.71993283
26MP0003566_abnormal_cell_adhesion1.70108169
27MP0002405_respiratory_system_inflammati1.68946340
28MP0005464_abnormal_platelet_physiology1.62153363
29MP0003300_gastrointestinal_ulcer1.62020294
30MP0001790_abnormal_immune_system1.61764711
31MP0005387_immune_system_phenotype1.61764711
32MP0001819_abnormal_immune_cell1.60834407
33MP0002420_abnormal_adaptive_immunity1.58766583
34MP0001533_abnormal_skeleton_physiology1.58130743
35MP0002723_abnormal_immune_serum1.57134636
36MP0002139_abnormal_hepatobiliary_system1.51378007
37MP0001853_heart_inflammation1.50571741
38MP0000015_abnormal_ear_pigmentation1.50410025
39MP0003724_increased_susceptibility_to1.49648112
40MP0010352_gastrointestinal_tract_polyps1.49275178
41MP0001800_abnormal_humoral_immune1.48701952
42MP0000858_altered_metastatic_potential1.47544776
43MP0003279_aneurysm1.47250384
44MP0005076_abnormal_cell_differentiation1.44010977
45MP0002998_abnormal_bone_remodeling1.42416231
46MP0000343_altered_response_to1.42407606
47MP0004947_skin_inflammation1.42128035
48MP0005671_abnormal_response_to1.42003271
49MP0002166_altered_tumor_susceptibility1.40119498
50MP0006054_spinal_hemorrhage1.39906651
51MP0000685_abnormal_immune_system1.38732950
52MP0002006_tumorigenesis1.38311989
53MP0005451_abnormal_body_composition1.37231833
54MP0005379_endocrine/exocrine_gland_phen1.35013821
55MP0000371_diluted_coat_color1.34367963
56MP0005075_abnormal_melanosome_morpholog1.31194085
57MP0000372_irregular_coat_pigmentation1.30060974
58MP0009278_abnormal_bone_marrow1.27578444
59MP0003656_abnormal_erythrocyte_physiolo1.25445387
60MP0003329_amyloid_beta_deposits1.25236238
61MP0001845_abnormal_inflammatory_respons1.21767651
62MP0003705_abnormal_hypodermis_morpholog1.20971158
63MP0000490_abnormal_crypts_of1.20963759
64MP0003195_calcinosis1.20863269
65MP0003091_abnormal_cell_migration1.15434607
66MP0003183_abnormal_peptide_metabolism1.15015712
67MP0010155_abnormal_intestine_physiology1.14500371
68MP0005023_abnormal_wound_healing1.13841999
69MP0009764_decreased_sensitivity_to1.13393580
70MP0000639_abnormal_adrenal_gland1.11057846
71MP0009333_abnormal_splenocyte_physiolog1.10247891
72MP0004808_abnormal_hematopoietic_stem1.09985383
73MP0004510_myositis1.09209734
74MP0005171_absent_coat_pigmentation1.08142301
75MP0003763_abnormal_thymus_physiology1.07256182
76MP0005647_abnormal_sex_gland1.06610333
77MP0005390_skeleton_phenotype1.05071830
78* MP0000716_abnormal_immune_system1.04928538
79MP0003828_pulmonary_edema1.04677180
80MP0008875_abnormal_xenobiotic_pharmacok1.03596585
81MP0004883_abnormal_blood_vessel1.03107960
82MP0010678_abnormal_skin_adnexa1.02496622
83MP0002909_abnormal_adrenal_gland1.02184046
84MP0001851_eye_inflammation1.01126587
85MP0002398_abnormal_bone_marrow0.99418183
86MP0000465_gastrointestinal_hemorrhage0.98837775
87MP0000689_abnormal_spleen_morphology0.98110135
88MP0008007_abnormal_cellular_replicative0.96441729
89MP0000767_abnormal_smooth_muscle0.95773972
90MP0003693_abnormal_embryo_hatching0.95345693
91MP0005164_abnormal_response_to0.92991608
92MP0001915_intracranial_hemorrhage0.92563728
93MP0002090_abnormal_vision0.92344975
94* MP0000647_abnormal_sebaceous_gland0.92032431
95MP0004381_abnormal_hair_follicle0.90987930
96* MP0002722_abnormal_immune_system0.90681405
97MP0003191_abnormal_cellular_cholesterol0.89969156
98MP0008004_abnormal_stomach_pH0.89908861
99MP0009384_cardiac_valve_regurgitation0.89659273
100* MP0002429_abnormal_blood_cell0.86936595
101MP0005365_abnormal_bile_salt0.86717795
102MP0005310_abnormal_salivary_gland0.85759064
103MP0003795_abnormal_bone_structure0.84761931
104MP0002933_joint_inflammation0.84719730
105MP0001175_abnormal_lung_morphology0.84645089
106MP0005166_decreased_susceptibility_to0.83652470
107MP0008260_abnormal_autophagy0.83407709
108MP0001243_abnormal_dermal_layer0.82882474
109MP0003453_abnormal_keratinocyte_physiol0.82354226
110MP0003011_delayed_dark_adaptation0.81307717
111MP0005165_increased_susceptibility_to0.80978127
112MP0002133_abnormal_respiratory_system0.80585033
113MP0005388_respiratory_system_phenotype0.80585033
114MP0008469_abnormal_protein_level0.80355185
115MP0002075_abnormal_coat/hair_pigmentati0.80334530
116MP0003690_abnormal_glial_cell0.78778951
117MP0003075_altered_response_to0.78429562
118MP0001186_pigmentation_phenotype0.78255785
119MP0000733_abnormal_muscle_development0.78234186
120MP0005197_abnormal_uvea_morphology0.78056400
121MP0002277_abnormal_respiratory_mucosa0.77743346
122MP0004272_abnormal_basement_membrane0.77380430
123MP0002095_abnormal_skin_pigmentation0.77015600
124MP0009763_increased_sensitivity_to0.76785766
125MP0001545_abnormal_hematopoietic_system0.76385311
126MP0005397_hematopoietic_system_phenotyp0.76385311
127MP0002295_abnormal_pulmonary_circulatio0.76045561
128MP0005275_abnormal_skin_tensile0.75892429
129MP0000609_abnormal_liver_physiology0.75592017
130MP0000383_abnormal_hair_follicle0.75486889
131MP0005408_hypopigmentation0.75141043
132MP0001661_extended_life_span0.74873482
133MP0002877_abnormal_melanocyte_morpholog0.74652354

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.97782250
2Eczematoid dermatitis (HP:0000976)5.36198850
3Recurrent bacterial skin infections (HP:0005406)5.11781132
4Increased cerebral lipofuscin (HP:0011813)4.80679002
5Vacuolated lymphocytes (HP:0001922)4.45485051
6Increased neuronal autofluorescent lipopigment (HP:0002074)4.33268331
7Abnormality of macrophages (HP:0004311)4.27008009
8Recurrent gram-negative bacterial infections (HP:0005420)4.04262771
9Abnormality of liposaccharide metabolism (HP:0010968)3.60172325
10Abnormality of glycosphingolipid metabolism (HP:0004343)3.60172325
11Abnormality of glycolipid metabolism (HP:0010969)3.60172325
12Gingivitis (HP:0000230)3.40862658
13Mediastinal lymphadenopathy (HP:0100721)3.38667790
14Interstitial pulmonary disease (HP:0006530)3.38174266
15Disinhibition (HP:0000734)3.20209054
16Obstructive lung disease (HP:0006536)2.98379297
17Chronic obstructive pulmonary disease (HP:0006510)2.98379297
18Periodontitis (HP:0000704)2.97171301
19Dysostosis multiplex (HP:0000943)2.96771217
20Autoimmune thrombocytopenia (HP:0001973)2.90929246
21Osteolytic defects of the phalanges of the hand (HP:0009771)2.90682740
22Osteolytic defects of the hand bones (HP:0009699)2.90682740
23Recurrent skin infections (HP:0001581)2.83918338
24Prostate neoplasm (HP:0100787)2.81771968
25Agnosia (HP:0010524)2.70762030
26Absent frontal sinuses (HP:0002688)2.67373871
27Prolonged neonatal jaundice (HP:0006579)2.65643094
28Recurrent fungal infections (HP:0002841)2.63465720
29Myositis (HP:0100614)2.62596450
30Hematochezia (HP:0002573)2.56957623
31Neurofibrillary tangles (HP:0002185)2.53928027
32Orchitis (HP:0100796)2.48276940
33Osteomyelitis (HP:0002754)2.47763369
34Urinary glycosaminoglycan excretion (HP:0003541)2.47598859
35Mucopolysacchariduria (HP:0008155)2.47598859
36Bilateral sensorineural hearing impairment (HP:0008619)2.46705982
37T lymphocytopenia (HP:0005403)2.40946785
38Thick nail (HP:0001805)2.40299066
39Abnormality of polysaccharide metabolism (HP:0011012)2.37677959
40Abnormality of glycosaminoglycan metabolism (HP:0004371)2.37677959
41Abnormality of mucopolysaccharide metabolism (HP:0011020)2.37677959
42Basal ganglia calcification (HP:0002135)2.36807138
43Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.35597955
44Xanthomatosis (HP:0000991)2.30723996
45Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.29918420
46Retrobulbar optic neuritis (HP:0100654)2.29581083
47Optic neuritis (HP:0100653)2.29581083
48Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.27036490
49Spondylolisthesis (HP:0003302)2.26353987
50Cellulitis (HP:0100658)2.24338029
51Axonal loss (HP:0003447)2.24245620
52Increased CSF protein (HP:0002922)2.23365596
53Abnormality of T cell number (HP:0011839)2.22739165
54Global brain atrophy (HP:0002283)2.22032983
55Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.21872820
56Vertebral compression fractures (HP:0002953)2.18585290
57Abnormality of the frontal sinuses (HP:0002687)2.18139512
58Premature loss of primary teeth (HP:0006323)2.17444786
59Mitral stenosis (HP:0001718)2.17206921
60Skin nodule (HP:0200036)2.16171318
61Pustule (HP:0200039)2.13092493
62Protuberant abdomen (HP:0001538)2.10927215
63Abnormality of the periventricular white matter (HP:0002518)2.08166470
64Recurrent pneumonia (HP:0006532)2.07277298
65Systemic lupus erythematosus (HP:0002725)2.06931474
66Loss of speech (HP:0002371)2.05877224
67Poor head control (HP:0002421)2.03074163
68Renal salt wasting (HP:0000127)2.02812405
69Cervical subluxation (HP:0003308)2.02675429
70Cerebral inclusion bodies (HP:0100314)2.02603936
71Cheilitis (HP:0100825)2.01863199
72Cutaneous melanoma (HP:0012056)1.99880418
73Progressive neurologic deterioration (HP:0002344)1.98331893
74Amyloidosis (HP:0011034)1.95688887
75Cerebral aneurysm (HP:0004944)1.93240410
76Bone pain (HP:0002653)1.90565554
77Epidermoid cyst (HP:0200040)1.90365345
78Elevated erythrocyte sedimentation rate (HP:0003565)1.90069302
79Abnormality of the vasculature of the conjunctiva (HP:0008054)1.89607839
80Cardiomegaly (HP:0001640)1.88778802
81Recurrent viral infections (HP:0004429)1.87965578
82Pathologic fracture (HP:0002756)1.87256771
83Spinal cord lesions (HP:0100561)1.85882474
84Syringomyelia (HP:0003396)1.85882474
85Retinal atrophy (HP:0001105)1.85255261
86Stomatitis (HP:0010280)1.84873937
87Subacute progressive viral hepatitis (HP:0006572)1.84553581
88Metaphyseal irregularity (HP:0003025)1.83305377
89Ovoid vertebral bodies (HP:0003300)1.83098091
90Myocardial infarction (HP:0001658)1.80644697
91Abnormality of the distal phalanges of the toes (HP:0010182)1.79280279
92Chronic mucocutaneous candidiasis (HP:0002728)1.77757250
93Recurrent cutaneous fungal infections (HP:0011370)1.77757250
94Asymmetric septal hypertrophy (HP:0001670)1.77147436
95Leukocytosis (HP:0001974)1.76835124
96Premature rupture of membranes (HP:0001788)1.76303040
97Pulmonary infiltrates (HP:0002113)1.76284246
98Abnormality of the nasal septum (HP:0000419)1.72613570
99Abnormality of the lumbar spine (HP:0100712)1.71765597
100Mutism (HP:0002300)1.71133370
101Hemoptysis (HP:0002105)1.70648459
102Esophageal neoplasm (HP:0100751)1.70398284
103Neoplasm of head and neck (HP:0012288)1.70398284
104Decreased circulating renin level (HP:0003351)1.70374444
105Tetraparesis (HP:0002273)1.70073903
106Recurrent lower respiratory tract infections (HP:0002783)1.70051770
107Coarse hair (HP:0002208)1.68688095
108Nuclear cataract (HP:0100018)1.68048068
109Hepatosplenomegaly (HP:0001433)1.67938916
110Eosinophilia (HP:0001880)1.67767657
111Acrocyanosis (HP:0001063)1.67601735
112Ocular albinism (HP:0001107)1.66313478
113Meningitis (HP:0001287)1.64863649
114Short nail (HP:0001799)1.63246599
115Pulmonary fibrosis (HP:0002206)1.63009799
116Increased serum ferritin (HP:0003281)1.62619668
117Urticaria (HP:0001025)1.62584808
118Glomerulopathy (HP:0100820)1.62227812
119Mucosal telangiectasiae (HP:0100579)1.62224941
120Chronic diarrhea (HP:0002028)1.61668906
121Diminished motivation (HP:0000745)1.59847220
122Spontaneous hematomas (HP:0007420)1.59677268
123Orthostatic hypotension (HP:0001278)1.59549101
124Abnormality of primary teeth (HP:0006481)1.55692488
125Gonadotropin excess (HP:0000837)1.55319610
126Conjunctival telangiectasia (HP:0000524)1.54875574
127Arterial thrombosis (HP:0004420)1.54184528
128J-shaped sella turcica (HP:0002680)1.53947535
129Albinism (HP:0001022)1.53525488
130Broad face (HP:0000283)1.50945667
131Vasculitis (HP:0002633)1.49675324
132Thoracic kyphosis (HP:0002942)1.48429794
133Deformed sella turcica (HP:0002681)1.48361239
134Apathy (HP:0000741)1.47714016
135Sepsis (HP:0100806)1.47344039
136Persistence of primary teeth (HP:0006335)1.46915401
137Upper motor neuron abnormality (HP:0002127)1.46442358
138Skin ulcer (HP:0200042)1.46030253
139Selective tooth agenesis (HP:0001592)1.45606950
140Glomerulonephritis (HP:0000099)1.45170534

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK3.08294874
2IRAK32.69425278
3MAP3K142.68416861
4PDK22.64239350
5IRAK42.49490826
6FRK2.47431170
7RIPK42.37182292
8KIT2.28387937
9BLK2.17844572
10NEK92.10817944
11STK102.05931549
12TBK11.97492214
13GRK71.97054049
14TYK21.88888337
15BMPR21.81596637
16RPS6KA41.79556838
17TGFBR21.77329254
18MAP4K11.76061048
19CDK121.71063152
20MKNK11.69180432
21MAP3K131.67318263
22TRPM71.56788593
23CAMK1D1.51079409
24ZAP701.50640071
25SCYL21.49558543
26CDK61.47281682
27DDR21.46711373
28JAK31.44483104
29MKNK21.44316306
30TESK11.44287021
31LRRK21.41695918
32TTN1.41338168
33NME21.40495513
34IKBKB1.38702937
35TEC1.38663140
36PAK41.34870399
37TXK1.31095979
38YES11.29937839
39ERBB41.28429354
40TAOK31.26612945
41STK41.26090683
42PIM11.25627313
43BMX1.24123817
44HCK1.17301565
45STK31.15921383
46TESK21.14434225
47AKT31.14393805
48IKBKE1.13329882
49CHUK1.13284021
50JAK11.12504810
51CSF1R1.12154070
52PTK61.11105141
53MST1R1.10574246
54MAP3K21.08982857
55EIF2AK31.08342932
56FER1.07682534
57MARK31.06783976
58PKN21.04599190
59BTK1.04181572
60MAP3K31.01596378
61ERBB30.99733160
62PDGFRB0.98946363
63LYN0.97991534
64EPHA30.97268778
65FGFR30.97049015
66MELK0.96557042
67NUAK10.96175166
68PIM20.94679699
69BRD40.93172758
70CSK0.92545759
71EPHB10.92470757
72EIF2AK20.91625505
73ITK0.90580407
74MST40.90144329
75CLK10.88505917
76CDC42BPA0.85849843
77CDK70.85828454
78ADRBK20.85335030
79RIPK10.84917623
80NEK20.84221813
81LCK0.83427433
82MAP3K10.82516347
83PDK10.81232430
84SYK0.78713918
85PDPK10.78523560
86MAP2K30.78055852
87FGR0.77704748
88STK240.76966375
89ERN10.76897733
90ZAK0.76357079
91PLK40.73212221
92CDC70.72978753
93PRKAA20.72562384
94ABL10.69707932
95PDGFRA0.67708064
96IRAK10.66351215
97ACVR1B0.65631730
98ABL20.65168714
99TRIB30.65053689
100MAPK110.64009759
101MAP3K50.62345900
102MAP3K80.62077794
103NEK60.60661246
104EGFR0.60428052
105GSK3A0.59730162
106LIMK10.58062867
107PTK2B0.56425628
108ICK0.55976250
109BRSK20.55151008
110CAMK1G0.54447162
111PRKCD0.53310935
112SIK30.53109179
113FLT30.52379158
114PIK3CG0.51197310
115JAK20.50008974
116AURKB0.49733297
117NLK0.48109274
118CDK40.47269750
119ATR0.46928308
120MAP3K100.46703529
121PRPF4B0.46506968
122FGFR40.46347913
123FGFR10.43883004
124MAPKAPK20.43836968
125RPS6KA60.43373604
126SGK30.43027397
127IGF1R0.42883864
128CAMKK20.42640940
129MOS0.42598554
130TGFBR10.42144680
131BMPR1B0.41272883
132TAOK20.39672114
133FES0.39102982
134MAP3K120.37793169
135MATK0.36932565
136MAPK70.35754578

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysosome_Homo sapiens_hsa041422.79407637
2Leishmaniasis_Homo sapiens_hsa051402.58685863
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.42156193
4Other glycan degradation_Homo sapiens_hsa005112.14085909
5Phagosome_Homo sapiens_hsa041452.06750159
6Toll-like receptor signaling pathway_Homo sapiens_hsa046201.98187331
7Osteoclast differentiation_Homo sapiens_hsa043801.98153673
8Malaria_Homo sapiens_hsa051441.91185638
9Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.89885763
10Legionellosis_Homo sapiens_hsa051341.88918173
11Tuberculosis_Homo sapiens_hsa051521.87904654
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.84322487
13Sulfur metabolism_Homo sapiens_hsa009201.79887944
14Antigen processing and presentation_Homo sapiens_hsa046121.75029665
15Pertussis_Homo sapiens_hsa051331.64560717
16Rheumatoid arthritis_Homo sapiens_hsa053231.59020056
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.55455011
18Staphylococcus aureus infection_Homo sapiens_hsa051501.53986124
19Measles_Homo sapiens_hsa051621.52734172
20Apoptosis_Homo sapiens_hsa042101.49240928
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.48637115
22Salmonella infection_Homo sapiens_hsa051321.47494330
23Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.44385365
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.40355354
25Shigellosis_Homo sapiens_hsa051311.39067455
26Toxoplasmosis_Homo sapiens_hsa051451.33778736
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.32124338
28Hematopoietic cell lineage_Homo sapiens_hsa046401.28857507
29Influenza A_Homo sapiens_hsa051641.27997147
30Leukocyte transendothelial migration_Homo sapiens_hsa046701.27394658
31TNF signaling pathway_Homo sapiens_hsa046681.26114623
32Graft-versus-host disease_Homo sapiens_hsa053321.25611164
33B cell receptor signaling pathway_Homo sapiens_hsa046621.23257942
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.22314717
35Herpes simplex infection_Homo sapiens_hsa051681.20552863
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19826405
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.18947273
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.18606178
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17878548
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12909707
41Small cell lung cancer_Homo sapiens_hsa052221.10699449
42Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10391176
43Sphingolipid metabolism_Homo sapiens_hsa006001.08177052
44Hepatitis B_Homo sapiens_hsa051611.08143003
45Asthma_Homo sapiens_hsa053101.07344490
46Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.07079565
47RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.06557378
48Fatty acid biosynthesis_Homo sapiens_hsa000611.05831306
49Adherens junction_Homo sapiens_hsa045201.03863676
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03552011
51Chronic myeloid leukemia_Homo sapiens_hsa052201.03267646
52MicroRNAs in cancer_Homo sapiens_hsa052061.02780887
53Fatty acid elongation_Homo sapiens_hsa000621.02368439
54Complement and coagulation cascades_Homo sapiens_hsa046101.02270064
55Proteoglycans in cancer_Homo sapiens_hsa052051.01053976
56Allograft rejection_Homo sapiens_hsa053300.96940956
57Viral myocarditis_Homo sapiens_hsa054160.95839985
58Mineral absorption_Homo sapiens_hsa049780.94988304
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.93756070
60p53 signaling pathway_Homo sapiens_hsa041150.92432881
61* Steroid biosynthesis_Homo sapiens_hsa001000.89399402
62Chemokine signaling pathway_Homo sapiens_hsa040620.89081027
63ECM-receptor interaction_Homo sapiens_hsa045120.88966401
64Pancreatic cancer_Homo sapiens_hsa052120.88375929
65Amoebiasis_Homo sapiens_hsa051460.88212251
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.87368775
67Viral carcinogenesis_Homo sapiens_hsa052030.84565681
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84448735
69Selenocompound metabolism_Homo sapiens_hsa004500.84254736
70Renin-angiotensin system_Homo sapiens_hsa046140.80197124
71Focal adhesion_Homo sapiens_hsa045100.80142486
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79899445
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78267202
74Homologous recombination_Homo sapiens_hsa034400.77708357
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77370278
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76485450
77Ovarian steroidogenesis_Homo sapiens_hsa049130.76021103
78Non-homologous end-joining_Homo sapiens_hsa034500.75473707
79TGF-beta signaling pathway_Homo sapiens_hsa043500.75113166
80DNA replication_Homo sapiens_hsa030300.72834070
81Prostate cancer_Homo sapiens_hsa052150.72529471
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72474038
83HTLV-I infection_Homo sapiens_hsa051660.71261506
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71231493
85Platelet activation_Homo sapiens_hsa046110.70153073
86Galactose metabolism_Homo sapiens_hsa000520.70029048
87Hepatitis C_Homo sapiens_hsa051600.69996139
88Cell cycle_Homo sapiens_hsa041100.69040607
89Epstein-Barr virus infection_Homo sapiens_hsa051690.68284358
90Systemic lupus erythematosus_Homo sapiens_hsa053220.66457654
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.65475618
92T cell receptor signaling pathway_Homo sapiens_hsa046600.64118250
93HIF-1 signaling pathway_Homo sapiens_hsa040660.63084043
94Acute myeloid leukemia_Homo sapiens_hsa052210.61931099
95PPAR signaling pathway_Homo sapiens_hsa033200.61647429
96Vibrio cholerae infection_Homo sapiens_hsa051100.60135043
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.58966161
98Notch signaling pathway_Homo sapiens_hsa043300.58806798
99Fanconi anemia pathway_Homo sapiens_hsa034600.57911804
100African trypanosomiasis_Homo sapiens_hsa051430.57676822
101Primary immunodeficiency_Homo sapiens_hsa053400.55500419
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.52169514
103Base excision repair_Homo sapiens_hsa034100.51331983
104Vitamin B6 metabolism_Homo sapiens_hsa007500.50455837
105Endocytosis_Homo sapiens_hsa041440.48317899
106Melanoma_Homo sapiens_hsa052180.48043243
107Pathways in cancer_Homo sapiens_hsa052000.47448297
108Prolactin signaling pathway_Homo sapiens_hsa049170.47144881
109Colorectal cancer_Homo sapiens_hsa052100.46288622
110Type I diabetes mellitus_Homo sapiens_hsa049400.46240757
111N-Glycan biosynthesis_Homo sapiens_hsa005100.45574658
112Dorso-ventral axis formation_Homo sapiens_hsa043200.45484342
113Bladder cancer_Homo sapiens_hsa052190.44866610
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44781376
115Autoimmune thyroid disease_Homo sapiens_hsa053200.42777862
116Glutathione metabolism_Homo sapiens_hsa004800.42206015
117Collecting duct acid secretion_Homo sapiens_hsa049660.41975098
118Mismatch repair_Homo sapiens_hsa034300.41060395
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.39481923
120Pentose phosphate pathway_Homo sapiens_hsa000300.39330105
121Tryptophan metabolism_Homo sapiens_hsa003800.38796450
122Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.29966363
123Fructose and mannose metabolism_Homo sapiens_hsa000510.29722468
124Insulin resistance_Homo sapiens_hsa049310.28934430
125mTOR signaling pathway_Homo sapiens_hsa041500.28852976
126Fatty acid metabolism_Homo sapiens_hsa012120.26835019
127Prion diseases_Homo sapiens_hsa050200.23691164

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »