ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	6.71795887
2	L-phenylalanine catabolic process (GO:0006559)	6.38681079
3	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	6.38681079
4	L-phenylalanine metabolic process (GO:0006558)	6.32916864
5	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	6.32916864
6	aromatic amino acid family catabolic process (GO:0009074)	6.06953168
7	high-density lipoprotein particle remodeling (GO:0034375)	5.92250545
8	tryptophan catabolic process (GO:0006569)	5.87534097
9	indole-containing compound catabolic process (GO:0042436)	5.87534097
10	indolalkylamine catabolic process (GO:0046218)	5.87534097
11	regulation of cholesterol esterification (GO:0010872)	5.67381814
12	tryptophan metabolic process (GO:0006568)	5.54564414
13	kynurenine metabolic process (GO:0070189)	5.47680325
14	phospholipid efflux (GO:0033700)	5.40785998
15	reverse cholesterol transport (GO:0043691)	5.27085028
16	urea cycle (GO:0000050)	5.25865721
17	urea metabolic process (GO:0019627)	5.25865721
18	sulfur amino acid catabolic process (GO:0000098)	5.25276138
19	glyoxylate metabolic process (GO:0046487)	5.16412854
20	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	5.12228731
21	protein-lipid complex remodeling (GO:0034368)	5.05990048
22	macromolecular complex remodeling (GO:0034367)	5.05990048
23	plasma lipoprotein particle remodeling (GO:0034369)	5.05990048
24	regulation of triglyceride catabolic process (GO:0010896)	4.99351588
25	triglyceride homeostasis (GO:0070328)	4.98524889
26	acylglycerol homeostasis (GO:0055090)	4.98524889
27	bile acid biosynthetic process (GO:0006699)	4.96886331
28	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	4.95642863
29	nitrogen cycle metabolic process (GO:0071941)	4.83487925
30	regulation of plasminogen activation (GO:0010755)	4.82002840
31	regulation of apoptotic cell clearance (GO:2000425)	4.80906981
32	negative regulation of fibrinolysis (GO:0051918)	4.79220374
33	* cholesterol efflux (GO:0033344)	4.75642822
34	peptidyl-glutamic acid carboxylation (GO:0017187)	4.73439240
35	protein carboxylation (GO:0018214)	4.73439240
36	serine family amino acid catabolic process (GO:0009071)	4.72380318
37	regulation of fibrinolysis (GO:0051917)	4.72032050
38	negative regulation of sterol transport (GO:0032372)	4.69032045
39	negative regulation of cholesterol transport (GO:0032375)	4.69032045
40	bile acid metabolic process (GO:0008206)	4.61927606
41	positive regulation of steroid metabolic process (GO:0045940)	4.60926224
42	diacylglycerol metabolic process (GO:0046339)	4.60413518
43	regulation of protein activation cascade (GO:2000257)	4.54137879
44	cysteine metabolic process (GO:0006534)	4.52709888
45	aromatic amino acid family metabolic process (GO:0009072)	4.50339201
46	alpha-linolenic acid metabolic process (GO:0036109)	4.48151948
47	* plasma lipoprotein particle assembly (GO:0034377)	4.44795104
48	positive regulation of triglyceride lipase activity (GO:0061365)	4.44096550
49	positive regulation of lipoprotein lipase activity (GO:0051006)	4.44096550
50	imidazole-containing compound metabolic process (GO:0052803)	4.39260239
51	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	4.36880246
52	complement activation, alternative pathway (GO:0006957)	4.36803722
53	regulation of cytokine secretion involved in immune response (GO:0002739)	4.33887383
54	cellular biogenic amine catabolic process (GO:0042402)	4.33538221
55	amine catabolic process (GO:0009310)	4.33538221
56	homocysteine metabolic process (GO:0050667)	4.27193800
57	* cholesterol transport (GO:0030301)	4.25762509
58	* sterol transport (GO:0015918)	4.25762509
59	indolalkylamine metabolic process (GO:0006586)	4.22238085
60	bile acid and bile salt transport (GO:0015721)	4.21728077
61	cellular glucuronidation (GO:0052695)	4.21370832
62	NAD biosynthetic process (GO:0009435)	4.19891791
63	* intestinal cholesterol absorption (GO:0030299)	4.19566557
64	positive regulation of fatty acid biosynthetic process (GO:0045723)	4.19115123
65	regulation of complement activation (GO:0030449)	4.16149367
66	regulation of bile acid biosynthetic process (GO:0070857)	4.12292741
67	plasma lipoprotein particle clearance (GO:0034381)	4.11960935
68	drug catabolic process (GO:0042737)	4.08987642
69	alpha-amino acid catabolic process (GO:1901606)	4.08590780
70	proline metabolic process (GO:0006560)	4.07940562
71	regulation of cholesterol biosynthetic process (GO:0045540)	4.07085008
72	tyrosine metabolic process (GO:0006570)	4.06263557
73	amino-acid betaine metabolic process (GO:0006577)	4.06109938
74	lipoprotein transport (GO:0042953)	4.04913894
75	low-density lipoprotein particle remodeling (GO:0034374)	4.02830974
76	proline biosynthetic process (GO:0006561)	4.01184923
77	lipoprotein metabolic process (GO:0042157)	4.00504640
78	* very-low-density lipoprotein particle assembly (GO:0034379)	3.98759615
79	* cholesterol homeostasis (GO:0042632)	3.89647116
80	glycine metabolic process (GO:0006544)	3.88104375
81	benzene-containing compound metabolic process (GO:0042537)	3.88098470
82	* plasma lipoprotein particle organization (GO:0071827)	3.88042707
83	negative regulation of fatty acid biosynthetic process (GO:0045717)	3.85748227
84	negative regulation of sodium ion transport (GO:0010766)	3.83757740
85	pyridine nucleotide biosynthetic process (GO:0019363)	3.83660451
86	nicotinamide nucleotide biosynthetic process (GO:0019359)	3.83660451
87	trivalent inorganic anion homeostasis (GO:0072506)	3.81660788
88	phosphate ion homeostasis (GO:0055062)	3.81660788
89	* protein-lipid complex assembly (GO:0065005)	3.81428937
90	* sterol homeostasis (GO:0055092)	3.81146067
91	modified amino acid transport (GO:0072337)	3.80859016
92	cellular amino acid catabolic process (GO:0009063)	3.74217838
93	uronic acid metabolic process (GO:0006063)	3.72905568
94	glucuronate metabolic process (GO:0019585)	3.72905568
95	response to nitrosative stress (GO:0051409)	3.72804434
96	negative regulation of protein activation cascade (GO:2000258)	3.71700507
97	arginine metabolic process (GO:0006525)	3.70966227
98	serine family amino acid metabolic process (GO:0009069)	3.70839254
99	low-density lipoprotein particle clearance (GO:0034383)	3.70121723
100	regulation of cholesterol homeostasis (GO:2000188)	3.68192382
101	glutamine family amino acid biosynthetic process (GO:0009084)	3.66365993
102	* lipid homeostasis (GO:0055088)	3.65893074
103	blood coagulation, intrinsic pathway (GO:0007597)	3.60820525
104	phospholipid homeostasis (GO:0055091)	3.59387512
105	flavonoid metabolic process (GO:0009812)	3.59106009
106	positive regulation of lipid catabolic process (GO:0050996)	3.58669888
107	regulation of heterotypic cell-cell adhesion (GO:0034114)	3.58636994
108	* protein-lipid complex subunit organization (GO:0071825)	3.55918706
109	serine family amino acid biosynthetic process (GO:0009070)	3.55891178
110	lysine metabolic process (GO:0006553)	3.54817914
111	lysine catabolic process (GO:0006554)	3.54817914
112	negative regulation of lipase activity (GO:0060192)	3.52231923
113	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	3.52002861
114	cellular ketone body metabolic process (GO:0046950)	3.52001016
115	cytolysis (GO:0019835)	3.48786312
116	coenzyme catabolic process (GO:0009109)	3.47991332
117	lung epithelium development (GO:0060428)	3.47939833
118	negative regulation of hemostasis (GO:1900047)	3.46504669
119	negative regulation of blood coagulation (GO:0030195)	3.46504669
120	heme transport (GO:0015886)	3.45053754
121	glutamate metabolic process (GO:0006536)	3.43776658
122	* intestinal absorption (GO:0050892)	3.42501106
123	aldehyde catabolic process (GO:0046185)	3.41148745
124	alkaloid metabolic process (GO:0009820)	3.36991939
125	cellular zinc ion homeostasis (GO:0006882)	3.34350304
126	regulation of cholesterol metabolic process (GO:0090181)	3.31305269
127	drinking behavior (GO:0042756)	3.29710804
128	neutral lipid catabolic process (GO:0046461)	3.29498739
129	acylglycerol catabolic process (GO:0046464)	3.29498739
130	positive regulation of extracellular matrix organization (GO:1903055)	3.24086381
131	nephron tubule morphogenesis (GO:0072078)	3.18541740
132	nephron epithelium morphogenesis (GO:0072088)	3.18541740
133	negative regulation of coagulation (GO:0050819)	3.17622965
134	L-ascorbic acid metabolic process (GO:0019852)	3.17412600
135	renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)	3.15649083
136	oligosaccharide catabolic process (GO:0009313)	3.15438490
137	acute-phase response (GO:0006953)	3.15216362
138	regulation of extracellular matrix organization (GO:1903053)	3.12923991
139	anion homeostasis (GO:0055081)	3.09376888
140	fibrinolysis (GO:0042730)	3.08690511
141	positive regulation of hormone metabolic process (GO:0032352)	3.07371404
142	C21-steroid hormone metabolic process (GO:0008207)	3.07355534
143	positive regulation of hemostasis (GO:1900048)	3.07051576
144	positive regulation of blood coagulation (GO:0030194)	3.07051576
145	regulation of humoral immune response (GO:0002920)	3.06815733
146	vitamin transmembrane transport (GO:0035461)	3.02061224
147	regulation of retinoic acid receptor signaling pathway (GO:0048385)	2.99449235
148	regulation of fatty acid biosynthetic process (GO:0042304)	2.99044612
149	cellular anion homeostasis (GO:0030002)	2.93147898
150	regulation of cell-cell adhesion mediated by cadherin (GO:2000047)	2.91337858

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RXR_22158963_ChIP-Seq_LIVER_Mouse	7.73565537
2	EGR1_23403033_ChIP-Seq_LIVER_Mouse	6.87279807
3	* PPARA_22158963_ChIP-Seq_LIVER_Mouse	6.70645459
4	LXR_22158963_ChIP-Seq_LIVER_Mouse	5.88557439
5	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	5.39639499
6	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	4.97921090
7	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	4.38480000
8	ZNF263_19887448_ChIP-Seq_K562_Human	4.19712909
9	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	3.74828019
10	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	3.35210720
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.93275993
12	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	10.1650784
13	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.95470122
14	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.91626311
15	* HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.90459802
16	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.75451957
17	AR_21909140_ChIP-Seq_LNCAP_Human	1.73284040
18	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.62623577
19	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.60793617
20	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.55669653
21	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.50638882
22	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.39921538
23	* HNF4A_19822575_ChIP-Seq_HepG2_Human	1.37037848
24	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.34745077
25	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.34176296
26	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.30519648
27	HTT_18923047_ChIP-ChIP_STHdh_Human	1.27805575
28	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.27481401
29	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.26934108
30	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.25149891
31	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.23315036
32	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.21478567
33	* RARA_24833708_ChIP-Seq_LIVER_Mouse	1.19497823
34	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.18529594
35	* GATA3_20176728_ChIP-ChIP_TSCs_Mouse	1.18466545
36	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.18240070
37	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.13768456
38	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.11116855
39	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.09220931
40	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.08610974
41	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.06902740
42	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.04952160
43	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.01865532
44	GATA4_25053715_ChIP-Seq_YYC3_Human	0.99066245
45	GATA1_22025678_ChIP-Seq_K562_Human	0.98460631
46	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.98076568
47	P68_20966046_ChIP-Seq_HELA_Human	0.95961951
48	GABP_19822575_ChIP-Seq_HepG2_Human	0.95869235
49	* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.93076981
50	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.92921663
51	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.92289992
52	RAC3_21632823_ChIP-Seq_H3396_Human	0.91963495
53	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.91385675
54	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.91258809
55	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.90158678
56	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.89805914
57	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.89539974
58	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.88834058
59	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.88116249
60	TP53_22127205_ChIP-Seq_IMR90_Human	0.88007527
61	RACK7_27058665_Chip-Seq_MCF-7_Human	0.86571670
62	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.86533985
63	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.86283543
64	IRF1_19129219_ChIP-ChIP_H3396_Human	0.86250024
65	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.85607869
66	* PU.1_20513432_ChIP-Seq_Bcells_Mouse	0.85583070
67	CSB_26484114_Chip-Seq_FIBROBLAST_Human	0.84696613
68	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.83265306
69	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.82622879
70	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.81806268
71	SMC4_20622854_ChIP-Seq_HELA_Human	0.80942199
72	OCT4_20526341_ChIP-Seq_ESCs_Human	0.80144278
73	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.79850061
74	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.79528621
75	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	0.79286978
76	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.78944301
77	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.78711457
78	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	0.78503898
79	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.77148908
80	GATA1_22383799_ChIP-Seq_G1ME_Mouse	0.76604969
81	* SPI1_26923725_Chip-Seq_HPCs_Mouse	0.75731788
82	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.75417959
83	* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.75131611
84	EOMES_21245162_ChIP-Seq_HESCs_Human	0.74506482
85	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.74223781
86	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.73551690
87	* SOX11_22085726_ChIP-Seq_ESNs_Mouse	0.73278112
88	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.73183869
89	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.72839641
90	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.72776622
91	E2F1_20622854_ChIP-Seq_HELA_Human	0.71838993
92	GATA6_25053715_ChIP-Seq_YYC3_Human	0.71302079
93	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.70966958
94	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.70724013
95	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	0.70533198
96	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.70075945
97	POU5F1_16518401_ChIP-PET_MESCs_Mouse	0.68070051
98	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	0.67305704
99	* GATA1_19941827_ChIP-Seq_MEL_Mouse	0.67057616
100	* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.66641687
101	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	0.66145352
102	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.66037788
103	NANOG_21062744_ChIP-ChIP_HESCs_Human	0.65746592
104	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.65716737
105	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.65268430
106	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.64869194
107	TP63_17297297_ChIP-ChIP_HaCaT_Human	0.64157409
108	* GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.63771286
109	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.63733407
110	ETS1_21867929_ChIP-Seq_TH2_Mouse	0.63316855
111	* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.63086163
112	* GATA2_22383799_ChIP-Seq_G1ME_Mouse	0.63023164
113	NACC1_18358816_ChIP-ChIP_MESCs_Mouse	0.62474096
114	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	0.62315674
115	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.61977213
116	CLOCK_20551151_ChIP-Seq_293T_Human	0.60965531
117	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.60715770
118	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.60459828
119	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.59915835
120	* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.59427399
121	BCL6_27268052_Chip-Seq_Bcells_Human	0.58198462
122	TCF3_18692474_ChIP-Seq_MESCs_Mouse	0.57174615
123	* LXR_22292898_ChIP-Seq_THP-1_Human	0.56916992
124	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.55347992
125	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.54994423
126	* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.54439404
127	STAT1_17558387_ChIP-Seq_HELA_Human	0.53834522
128	BCOR_27268052_Chip-Seq_Bcells_Human	0.53748957
129	* LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.53187354
130	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.52714721
131	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.52680223
132	EGR1_19032775_ChIP-ChIP_M12_Human	0.52280335
133	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.52069170
134	AR_20517297_ChIP-Seq_VCAP_Human	0.51430436
135	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.51073685
136	BRD4_27068464_Chip-Seq_AML-cells_Mouse	0.50589408
137	LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.50244627
138	SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.50127537
139	CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.50107976
140	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.49923979
141	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.49399176
142	PHF8_20622854_ChIP-Seq_HELA_Human	0.49391904
143	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.48620265
144	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.47886507
145	ESET_19884257_ChIP-Seq_ESCs_Mouse	0.47547263
146	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.47068600
147	CEBPB_22108803_ChIP-Seq_LS180_Human	0.46251169
148	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	0.45765943
149	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	0.45765943

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	7.60064050
2	MP0005360_urolithiasis	7.51603174
3	MP0005085_abnormal_gallbladder_physiolo	6.20565988
4	MP0005365_abnormal_bile_salt	5.82847486
5	MP0008875_abnormal_xenobiotic_pharmacok	4.67269466
6	MP0003122_maternal_imprinting	4.61508792
7	MP0003806_abnormal_nucleotide_metabolis	3.81951315
8	MP0003252_abnormal_bile_duct	3.70562594
9	MP0009840_abnormal_foam_cell	3.31396069
10	* MP0010329_abnormal_lipoprotein_level	3.27502027
11	* MP0001666_abnormal_nutrient_absorption	2.75305589
12	MP0004019_abnormal_vitamin_homeostasis	2.48892932
13	MP0003123_paternal_imprinting	2.46257844
14	MP0005332_abnormal_amino_acid	2.37226903
15	MP0003195_calcinosis	2.32328688
16	MP0003172_abnormal_lysosome_physiology	2.22677757
17	MP0003191_abnormal_cellular_cholesterol	2.22391160
18	MP0002089_abnormal_postnatal_growth/wei	2.22173252
19	MP0005058_abnormal_lysosome_morphology	2.17946177
20	MP0005083_abnormal_biliary_tract	2.14629184
21	MP0008260_abnormal_autophagy	2.10392903
22	MP0009697_abnormal_copulation	2.09577906
23	* MP0000609_abnormal_liver_physiology	2.00165922
24	MP0001764_abnormal_homeostasis	1.98049935
25	MP0002138_abnormal_hepatobiliary_system	1.83959417
26	MP0001986_abnormal_taste_sensitivity	1.82203266
27	* MP0002118_abnormal_lipid_homeostasis	1.79490931
28	MP0005319_abnormal_enzyme/_coenzyme	1.66049303
29	MP0003656_abnormal_erythrocyte_physiolo	1.58611987
30	MP0001915_intracranial_hemorrhage	1.49789438
31	MP0003183_abnormal_peptide_metabolism	1.49156891
32	MP0003868_abnormal_feces_composition	1.43515168
33	MP0005451_abnormal_body_composition	1.41468598
34	MP0009780_abnormal_chondrocyte_physiolo	1.38129542
35	MP0003186_abnormal_redox_activity	1.33952667
36	MP0006054_spinal_hemorrhage	1.33410732
37	MP0002132_abnormal_respiratory_system	1.30521407
38	MP0003121_genomic_imprinting	1.30395029
39	MP0009384_cardiac_valve_regurgitation	1.22851472
40	MP0005409_darkened_coat_color	1.21857706
41	MP0005257_abnormal_intraocular_pressure	1.20158204
42	MP0005584_abnormal_enzyme/coenzyme_acti	1.16052006
43	MP0000598_abnormal_liver_morphology	1.14499117
44	MP0004264_abnormal_extraembryonic_tissu	1.13677097
45	MP0009764_decreased_sensitivity_to	1.13634663
46	MP0005647_abnormal_sex_gland	1.13498509
47	MP0002876_abnormal_thyroid_physiology	1.11142715
48	MP0003950_abnormal_plasma_membrane	1.08638020
49	MP0002254_reproductive_system_inflammat	1.06934437
50	MP0003315_abnormal_perineum_morphology	1.05660301
51	MP0009643_abnormal_urine_homeostasis	1.05363718
52	MP0003718_maternal_effect	1.03557873
53	MP0003567_abnormal_fetal_cardiomyocyte	1.03184407
54	MP0005464_abnormal_platelet_physiology	1.02617598
55	MP0009333_abnormal_splenocyte_physiolog	1.01939046
56	MP0005084_abnormal_gallbladder_morpholo	1.01463328
57	MP0003878_abnormal_ear_physiology	1.01027584
58	MP0005377_hearing/vestibular/ear_phenot	1.01027584
59	MP0002938_white_spotting	1.01000860
60	MP0008469_abnormal_protein_level	0.93645456
61	MP0003879_abnormal_hair_cell	0.91448375
62	MP0003011_delayed_dark_adaptation	0.91240240
63	MP0004272_abnormal_basement_membrane	0.91085798
64	MP0008057_abnormal_DNA_replication	0.89428167
65	MP0009763_increased_sensitivity_to	0.89406915
66	MP0004782_abnormal_surfactant_physiolog	0.87655586
67	MP0005376_homeostasis/metabolism_phenot	0.85214494
68	* MP0009642_abnormal_blood_homeostasis	0.83499235
69	MP0005075_abnormal_melanosome_morpholog	0.82911330
70	MP0002933_joint_inflammation	0.80693582
71	MP0005408_hypopigmentation	0.80528576
72	MP0009765_abnormal_xenobiotic_induced	0.80335891
73	MP0008438_abnormal_cutaneous_collagen	0.80157767
74	MP0005636_abnormal_mineral_homeostasis	0.78031940
75	MP0003329_amyloid_beta_deposits	0.77608967
76	MP0005220_abnormal_exocrine_pancreas	0.77049144
77	MP0002160_abnormal_reproductive_system	0.74825310
78	MP0005266_abnormal_metabolism	0.74570240
79	MP0001661_extended_life_span	0.74497819
80	MP0006082_CNS_inflammation	0.74220221
81	MP0005670_abnormal_white_adipose	0.73419497
82	MP0005410_abnormal_fertilization	0.73130569
83	MP0001270_distended_abdomen	0.72446671
84	MP0005334_abnormal_fat_pad	0.71131202
85	MP0009053_abnormal_anal_canal	0.69691804
86	MP0003942_abnormal_urinary_system	0.69123533
87	MP0003724_increased_susceptibility_to	0.67967222
88	MP0005448_abnormal_energy_balance	0.67453453
89	MP0005076_abnormal_cell_differentiation	0.65567300
90	MP0003115_abnormal_respiratory_system	0.65424181
91	MP0003943_abnormal_hepatobiliary_system	0.64325397
92	MP0003436_decreased_susceptibility_to	0.63920986
93	MP0002078_abnormal_glucose_homeostasis	0.63683759
94	MP0004147_increased_porphyrin_level	0.62371621
95	MP0001293_anophthalmia	0.60501395
96	MP0009115_abnormal_fat_cell	0.60280538
97	MP0000639_abnormal_adrenal_gland	0.59685468
98	MP0003453_abnormal_keratinocyte_physiol	0.59407274
99	MP0000566_synostosis	0.59011290
100	MP0006036_abnormal_mitochondrial_physio	0.57887983
101	MP0005167_abnormal_blood-brain_barrier	0.57715719
102	MP0005395_other_phenotype	0.57612422
103	MP0010155_abnormal_intestine_physiology	0.57088578
104	MP0002086_abnormal_extraembryonic_tissu	0.56219308
105	MP0005248_abnormal_Harderian_gland	0.56144877
106	MP0002971_abnormal_brown_adipose	0.55473734
107	MP0001765_abnormal_ion_homeostasis	0.54944406
108	MP0003941_abnormal_skin_development	0.54023345
109	MP0004883_abnormal_blood_vessel	0.53188743
110	MP0001845_abnormal_inflammatory_respons	0.52311470
111	MP0000685_abnormal_immune_system	0.52016317
112	MP0009785_altered_susceptibility_to	0.51780786
113	MP0001324_abnormal_eye_pigmentation	0.50901843
114	MP0003638_abnormal_response/metabolism_	0.50613806
115	MP0001730_embryonic_growth_arrest	0.50478954
116	MP0000371_diluted_coat_color	0.50249690
117	MP0000579_abnormal_nail_morphology	0.49602825
118	MP0002060_abnormal_skin_morphology	0.48324071
119	MP0002909_abnormal_adrenal_gland	0.48309851
120	MP0002092_abnormal_eye_morphology	0.47535918
121	MP0006292_abnormal_olfactory_placode	0.45836886
122	MP0000858_altered_metastatic_potential	0.44870182
123	MP0002136_abnormal_kidney_physiology	0.44701836
124	MP0008995_early_reproductive_senescence	0.44698833
125	MP0001545_abnormal_hematopoietic_system	0.44395474
126	MP0005397_hematopoietic_system_phenotyp	0.44395474
127	MP0008872_abnormal_physiological_respon	0.44225990
128	MP0001697_abnormal_embryo_size	0.44009688
129	MP0001835_abnormal_antigen_presentation	0.43374695
130	MP0005025_abnormal_response_to	0.42836515
131	MP0003953_abnormal_hormone_level	0.41563209
132	MP0002928_abnormal_bile_duct	0.41479702
133	MP0005389_reproductive_system_phenotype	0.41370528
134	MP0002822_catalepsy	0.41311847
135	MP0001286_abnormal_eye_development	0.41156830
136	MP0004381_abnormal_hair_follicle	0.41112704
137	MP0000920_abnormal_myelination	0.40872775
138	MP0002166_altered_tumor_susceptibility	0.40736691
139	MP0008873_increased_physiological_sensi	0.40556943
140	MP0002796_impaired_skin_barrier	0.39860494
141	MP0003705_abnormal_hypodermis_morpholog	0.39747038
142	MP0001119_abnormal_female_reproductive	0.38979727
143	MP0002419_abnormal_innate_immunity	0.35924187
144	MP0010368_abnormal_lymphatic_system	0.35528879
145	MP0002098_abnormal_vibrissa_morphology	0.35526845
146	MP0005535_abnormal_body_temperature	0.34100881
147	MP0001756_abnormal_urination	0.33403649
148	MP0003699_abnormal_female_reproductive	0.33091728
149	MP0000604_amyloidosis	0.32375188
150	MP0003890_abnormal_embryonic-extraembry	0.32140851
151	MP0001873_stomach_inflammation	0.31933613

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypobetalipoproteinemia (HP:0003563)	6.95912322
2	Intrahepatic cholestasis (HP:0001406)	6.50127724
3	Abnormality of aromatic amino acid family metabolism (HP:0004338)	6.40559181
4	Abnormality of monocarboxylic acid metabolism (HP:0010996)	6.10514855
5	Prolonged partial thromboplastin time (HP:0003645)	6.07288118
6	Deep venous thrombosis (HP:0002625)	5.81479145
7	Xanthomatosis (HP:0000991)	5.34481038
8	Joint hemorrhage (HP:0005261)	4.77911521
9	Hypolipoproteinemia (HP:0010981)	4.77113260
10	Hyperlipoproteinemia (HP:0010980)	4.42532090
11	Fat malabsorption (HP:0002630)	4.34238536
12	Conjugated hyperbilirubinemia (HP:0002908)	4.33075442
13	Abnormality of glutamine family amino acid metabolism (HP:0010902)	4.30765953
14	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	4.24782021
15	Hemorrhage of the eye (HP:0011885)	4.21895817
16	Hypochromic microcytic anemia (HP:0004840)	4.21876142
17	Complement deficiency (HP:0004431)	4.09846439
18	Abnormality of pyrimidine metabolism (HP:0004353)	4.09493111
19	Abnormality of sulfur amino acid metabolism (HP:0004339)	3.98749518
20	Abnormality of the common coagulation pathway (HP:0010990)	3.93997554
21	Epidermoid cyst (HP:0200040)	3.93864169
22	Abnormality of aspartate family amino acid metabolism (HP:0010899)	3.89671219
23	Hyperammonemia (HP:0001987)	3.89415652
24	Abnormality of methionine metabolism (HP:0010901)	3.86554236
25	Hyperglycinuria (HP:0003108)	3.77673675
26	Hyperglycinemia (HP:0002154)	3.69869241
27	Hypercholesterolemia (HP:0003124)	3.59991190
28	Hypoalphalipoproteinemia (HP:0003233)	3.54546843
29	Broad alveolar ridges (HP:0000187)	3.51899885
30	Abnormality of carpal bone ossification (HP:0006257)	3.49585318
31	Hypoglycemic coma (HP:0001325)	3.45789066
32	Hyperbilirubinemia (HP:0002904)	3.38248961
33	Abnormality of glycine metabolism (HP:0010895)	3.35339275
34	Abnormality of serine family amino acid metabolism (HP:0010894)	3.35339275
35	Acanthocytosis (HP:0001927)	3.33611722
36	Ketosis (HP:0001946)	3.33302093
37	Small epiphyses (HP:0010585)	3.32324768
38	Abnormality of the intrinsic pathway (HP:0010989)	3.29624963
39	Vaginal fistula (HP:0004320)	3.19583050
40	Abnormality of complement system (HP:0005339)	3.19405140
41	Steatorrhea (HP:0002570)	3.13890057
42	Abnormal tarsal ossification (HP:0008369)	3.13192474
43	Hypophosphatemic rickets (HP:0004912)	3.05010455
44	Myocardial infarction (HP:0001658)	2.97756691
45	Abnormality of nucleobase metabolism (HP:0010932)	2.97039525
46	Poikilocytosis (HP:0004447)	2.96423479
47	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.82725123
48	Abnormality of fatty-acid metabolism (HP:0004359)	2.76162709
49	Broad palm (HP:0001169)	2.75248189
50	Malnutrition (HP:0004395)	2.68414907
51	Hypoglycemic seizures (HP:0002173)	2.66204323
52	Pigmentary retinal degeneration (HP:0001146)	2.66124300
53	Purpura (HP:0000979)	2.64759096
54	Abnormality of serum amino acid levels (HP:0003112)	2.64254128
55	Abnormal hand bone ossification (HP:0010660)	2.63873270
56	Spontaneous abortion (HP:0005268)	2.63820072
57	Increased serum pyruvate (HP:0003542)	2.63731993
58	Opisthotonus (HP:0002179)	2.63664279
59	Systemic lupus erythematosus (HP:0002725)	2.60242731
60	Metabolic acidosis (HP:0001942)	2.56383203
61	Menorrhagia (HP:0000132)	2.54389651
62	Gingival bleeding (HP:0000225)	2.52417088
63	Abnormal ossification of hand bones (HP:0005921)	2.51610824
64	Widely patent fontanelles and sutures (HP:0004492)	2.51001812
65	Hepatocellular carcinoma (HP:0001402)	2.50538454
66	Hepatoblastoma (HP:0002884)	2.50310634
67	Abnormality of the nasal septum (HP:0000419)	2.50218301
68	Potter facies (HP:0002009)	2.46852486
69	Facial shape deformation (HP:0011334)	2.46852486
70	Ketoacidosis (HP:0001993)	2.46477701
71	Flat acetabular roof (HP:0003180)	2.45680831
72	Flared iliac wings (HP:0002869)	2.45495260
73	Mitral stenosis (HP:0001718)	2.41682871
74	Abnormality of purine metabolism (HP:0004352)	2.40812732
75	Delayed CNS myelination (HP:0002188)	2.40055327
76	Vascular calcification (HP:0004934)	2.38402862
77	Alopecia of scalp (HP:0002293)	2.37604486
78	Abnormality of the lumbar spine (HP:0100712)	2.35447829
79	Hypochromic anemia (HP:0001931)	2.30211291
80	Renal cortical cysts (HP:0000803)	2.29877372
81	Abnormality of glycolysis (HP:0004366)	2.28348796
82	Recurrent gram-negative bacterial infections (HP:0005420)	2.24561078
83	Supernumerary spleens (HP:0009799)	2.23215542
84	Lethargy (HP:0001254)	2.22960378
85	Alacrima (HP:0000522)	2.22422743
86	Abnormality of proline metabolism (HP:0010907)	2.21049721
87	Hydroxyprolinuria (HP:0003080)	2.21049721
88	Pustule (HP:0200039)	2.18367307
89	Asymmetry of the thorax (HP:0001555)	2.17789558
90	Pancreatitis (HP:0001733)	2.16949635
91	Abnormal gallbladder morphology (HP:0012437)	2.14731302
92	Glomerulonephritis (HP:0000099)	2.11993851
93	Epiphyseal dysplasia (HP:0002656)	2.11601559
94	Osteomalacia (HP:0002749)	2.07687503
95	Pancreatic islet-cell hyperplasia (HP:0004510)	2.07362872
96	Abnormality of the alveolar ridges (HP:0006477)	2.06341959
97	Retinal atrophy (HP:0001105)	2.06216623
98	Symptomatic seizures (HP:0011145)	2.05910914
99	Increased mean platelet volume (HP:0011877)	2.04885095
100	Generalized aminoaciduria (HP:0002909)	2.04759698
101	Abnormal platelet volume (HP:0011876)	2.04384800
102	Dicarboxylic aciduria (HP:0003215)	2.04159037
103	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.04159037
104	Cholelithiasis (HP:0001081)	2.03904706
105	Thrombophlebitis (HP:0004418)	2.02775514
106	Irregular epiphyses (HP:0010582)	2.00380590
107	Cardiovascular calcification (HP:0011915)	1.97822179
108	Irritability (HP:0000737)	1.97662965
109	Enlarged kidneys (HP:0000105)	1.97429287
110	Diastasis recti (HP:0001540)	1.95856577
111	Abnormality of the wing of the ilium (HP:0011867)	1.95313277
112	Abnormal foot bone ossification (HP:0010675)	1.95236900
113	Esophageal varix (HP:0002040)	1.94651925
114	Skin nodule (HP:0200036)	1.94014005
115	Abnormality of transition element cation homeostasis (HP:0011030)	1.93293031
116	Rectovaginal fistula (HP:0000143)	1.92830672
117	Rectal fistula (HP:0100590)	1.92830672
118	Abnormality of urine glucose concentration (HP:0011016)	1.92390415
119	Glycosuria (HP:0003076)	1.92390415
120	Abnormality of vitamin metabolism (HP:0100508)	1.92117405
121	Polycythemia (HP:0001901)	1.91987461
122	Rickets (HP:0002748)	1.91899360
123	Joint swelling (HP:0001386)	1.91646738
124	Acute hepatic failure (HP:0006554)	1.91467705
125	Reticulocytosis (HP:0001923)	1.90921964
126	Arthropathy (HP:0003040)	1.89471678
127	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.89265878
128	Abnormal gallbladder physiology (HP:0012438)	1.88684478
129	Cholecystitis (HP:0001082)	1.88684478
130	Abnormal enzyme/coenzyme activity (HP:0012379)	1.88213861
131	Abnormality of endocrine pancreas physiology (HP:0012093)	1.84436187
132	Abnormality of the pancreatic islet cells (HP:0006476)	1.84436187
133	Hyperinsulinemic hypoglycemia (HP:0000825)	1.83811525
134	Amyloidosis (HP:0011034)	1.83487463
135	Lower limb hyperreflexia (HP:0002395)	1.82588723
136	Abnormality of iron homeostasis (HP:0011031)	1.82336425
137	Wide cranial sutures (HP:0010537)	1.81599817
138	Abnormal delivery (HP:0001787)	1.80483413
139	Anorexia (HP:0002039)	1.79827723
140	Gout (HP:0001997)	1.79613737
141	Brushfield spots (HP:0001088)	1.79319830
142	Proximal tubulopathy (HP:0000114)	1.78842125
143	Late onset (HP:0003584)	1.78358119
144	Intestinal fistula (HP:0100819)	1.77211237
145	Abnormality of the acetabulum (HP:0003170)	1.76012263
146	Prenatal maternal abnormality (HP:0002686)	1.70897936
147	Protrusio acetabuli (HP:0003179)	1.70761566
148	Megaloblastic anemia (HP:0001889)	1.69932560
149	Abnormal connection of the cardiac segments (HP:0011545)	1.69647913
150	Abnormal ventriculo-arterial connection (HP:0011563)	1.69647913

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	4.96570061
2	FGFR3	4.65250032
3	BCKDK	3.79616873
4	WNK4	3.54012304
5	MAPK15	3.48340287
6	AKT3	2.93875928
7	PINK1	2.91526838
8	TYRO3	2.69435803
9	IRAK3	2.60733820
10	FGFR4	2.56539010
11	INSRR	2.49705156
12	CDK12	2.40889906
13	MAP3K6	2.38987096
14	MAP3K11	2.31571566
15	ICK	2.28663349
16	TAOK3	2.28316861
17	FGFR2	2.23162368
18	MAP3K14	2.12993326
19	SIK1	2.01035973
20	PDK2	2.00438011
21	FGFR1	1.97686238
22	MAPK11	1.85653070
23	ERN1	1.80948656
24	PDGFRA	1.78507846
25	TAOK2	1.75941828
26	RIPK1	1.73478074
27	MST1R	1.73394778
28	YES1	1.70666256
29	ACVR1B	1.66297533
30	SIK2	1.62189500
31	CSK	1.60396360
32	EPHA2	1.50352434
33	PIM2	1.48085608
34	DDR2	1.48054499
35	ZAK	1.47885021
36	FLT3	1.47672714
37	ERBB4	1.46636177
38	TXK	1.41480942
39	FRK	1.40586686
40	MATK	1.40232728
41	EIF2AK1	1.39175330
42	PBK	1.38324111
43	DYRK1B	1.36256623
44	PIK3CA	1.34949140
45	IRAK4	1.34401178
46	WNK1	1.34258576
47	TYK2	1.33432480
48	STK38L	1.31455205
49	PIM1	1.18568802
50	PDPK1	1.17841323
51	MAPKAPK3	1.17080297
52	TRIB3	1.16094672
53	MAP3K3	1.15785427
54	CDK6	1.14043637
55	RET	1.13425400
56	IKBKB	1.04401623
57	CHUK	1.03504666
58	DAPK1	1.02040603
59	EEF2K	1.01630693
60	BMX	0.99784264
61	PIK3CG	0.99734503
62	ITK	0.99449789
63	CDK7	0.99031609
64	TRPM7	0.98907529
65	BRSK1	0.98820378
66	IKBKE	0.96714122
67	PRPF4B	0.95655001
68	PRKAA2	0.95059750
69	GSK3A	0.90817596
70	EPHA4	0.89230856
71	BRD4	0.88220353
72	MAP3K2	0.85621591
73	TBK1	0.85044743
74	MAP4K1	0.84307161
75	PDK1	0.83383544
76	ERBB3	0.81511262
77	NUAK1	0.80980422
78	RPS6KL1	0.80892966
79	RPS6KC1	0.80892966
80	GRK6	0.80456517
81	TGFBR2	0.80361906
82	LATS2	0.78633667
83	RPS6KA6	0.78043806
84	PRKAA1	0.76794775
85	STK16	0.76505769
86	MAP2K6	0.76087108
87	SGK2	0.75266131
88	MAPK4	0.73854483
89	NEK2	0.72037061
90	LATS1	0.71865900
91	JAK2	0.70874407
92	BMPR2	0.70751392
93	PKN2	0.69441940
94	TEC	0.68515223
95	GRK1	0.68247544
96	MAP3K10	0.67869146
97	RPS6KB1	0.67418144
98	NEK9	0.67331936
99	BTK	0.67328481
100	MAP2K3	0.67189125
101	SGK3	0.67051697
102	MAP2K2	0.65253379
103	LYN	0.65068328
104	TNK2	0.65032339
105	KSR2	0.64027531
106	PLK4	0.63743235
107	MAP3K1	0.61362086
108	JAK1	0.60906987
109	EIF2AK3	0.60481597
110	CSF1R	0.60225479
111	CDC42BPA	0.58915525
112	PRKG2	0.58075207
113	PRKCZ	0.57458024
114	PTK6	0.56013766
115	BRSK2	0.55844382
116	SGK494	0.54253811
117	SGK223	0.54253811
118	CAMK2G	0.53482338
119	LMTK2	0.53024512
120	MAPK3	0.52787500
121	EPHA3	0.52764527
122	CDK4	0.52009334
123	IRAK1	0.51595903
124	STK39	0.51193643
125	CSNK1E	0.50383304
126	CDK8	0.50341410
127	FGR	0.50011511
128	ERBB2	0.49517991
129	NME1	0.48051836
130	JAK3	0.47491171
131	CSNK2A1	0.45543457
132	MST4	0.45292363
133	ALK	0.45221732
134	CSNK2A2	0.45159407
135	SMG1	0.44402808
136	PRKD2	0.44257501
137	PRKACG	0.44137861
138	EIF2AK2	0.42165864
139	ATR	0.40119056
140	NLK	0.39811846
141	SRPK1	0.39558496
142	STK4	0.39180902
143	ZAP70	0.38817175
144	RPS6KA1	0.38401139
145	ADRBK2	0.37776297
146	TIE1	0.37559964
147	SGK1	0.37504351
148	STK3	0.36852124
149	CHEK2	0.36153983
150	IGF1R	0.32665772
151	MTOR	0.31641023
152	MAPKAPK2	0.29103180
153	MELK	0.29041183
154	CDK9	0.28706899
155	SRC	0.26464375
156	CSNK1D	0.23315128
157	CDK1	0.21753955
158	MAP3K7	0.21570727
159	NTRK2	0.19601706
160	LCK	0.19572706
161	PRKACB	0.17270028
162	CDK2	0.16482983
163	NTRK3	0.16013422

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.95839954
2	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.35289853
3	Arginine biosynthesis_Homo sapiens_hsa00220	2.80670599
4	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.66346864
5	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.60573904
6	Tryptophan metabolism_Homo sapiens_hsa00380	2.57786579
7	Complement and coagulation cascades_Homo sapiens_hsa04610	2.50151264
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.37922876
9	Other glycan degradation_Homo sapiens_hsa00511	2.32984530
10	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.32064675
11	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.26043512
12	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.16998350
13	Fatty acid degradation_Homo sapiens_hsa00071	2.13217729
14	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.11718098
15	Histidine metabolism_Homo sapiens_hsa00340	2.06123781
16	Drug metabolism - other enzymes_Homo sapiens_hsa00983	2.04328285
17	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.02870809
18	Peroxisome_Homo sapiens_hsa04146	2.02035841
19	Chemical carcinogenesis_Homo sapiens_hsa05204	2.00847606
20	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.97476234
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.94984149
22	Fat digestion and absorption_Homo sapiens_hsa04975	1.92730407
23	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.90706144
24	Caffeine metabolism_Homo sapiens_hsa00232	1.87236191
25	Retinol metabolism_Homo sapiens_hsa00830	1.84871870
26	Folate biosynthesis_Homo sapiens_hsa00790	1.81621128
27	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.73794741
28	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.71550950
29	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.70904859
30	beta-Alanine metabolism_Homo sapiens_hsa00410	1.69432587
31	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.67772340
32	PPAR signaling pathway_Homo sapiens_hsa03320	1.66567706
33	Fatty acid metabolism_Homo sapiens_hsa01212	1.66142607
34	Butanoate metabolism_Homo sapiens_hsa00650	1.61696883
35	Selenocompound metabolism_Homo sapiens_hsa00450	1.60910129
36	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.49530464
37	ABC transporters_Homo sapiens_hsa02010	1.48398936
38	Sulfur metabolism_Homo sapiens_hsa00920	1.46594091
39	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.43780377
40	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.42035492
41	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.41739609
42	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.41388344
43	Phenylalanine metabolism_Homo sapiens_hsa00360	1.41033459
44	Propanoate metabolism_Homo sapiens_hsa00640	1.38390773
45	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.37371009
46	Arginine and proline metabolism_Homo sapiens_hsa00330	1.33139343
47	Bile secretion_Homo sapiens_hsa04976	1.30263498
48	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.27828034
49	Sulfur relay system_Homo sapiens_hsa04122	1.24083427
50	Tyrosine metabolism_Homo sapiens_hsa00350	1.23846298
51	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.22295202
52	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.17202640
53	One carbon pool by folate_Homo sapiens_hsa00670	1.16839216
54	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.09809365
55	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.09232403
56	Fatty acid elongation_Homo sapiens_hsa00062	1.08311773
57	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.06984001
58	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.03382144
59	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.02600596
60	Pyruvate metabolism_Homo sapiens_hsa00620	1.00794992
61	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.99210044
62	Sphingolipid metabolism_Homo sapiens_hsa00600	0.96436658
63	Glutathione metabolism_Homo sapiens_hsa00480	0.95947419
64	Galactose metabolism_Homo sapiens_hsa00052	0.93074746
65	Lysine degradation_Homo sapiens_hsa00310	0.92063517
66	Carbon metabolism_Homo sapiens_hsa01200	0.82488268
67	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.74716757
68	* Steroid biosynthesis_Homo sapiens_hsa00100	0.69869220
69	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.68672697
70	Glycerolipid metabolism_Homo sapiens_hsa00561	0.67094159
71	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.63501985
72	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.63061905
73	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.57063248
74	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.55253506
75	Pentose phosphate pathway_Homo sapiens_hsa00030	0.53834473
76	Metabolic pathways_Homo sapiens_hsa01100	0.53394341
77	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.45492081
78	Renin-angiotensin system_Homo sapiens_hsa04614	0.43525922
79	Protein digestion and absorption_Homo sapiens_hsa04974	0.41771048
80	Linoleic acid metabolism_Homo sapiens_hsa00591	0.40740229
81	Glucagon signaling pathway_Homo sapiens_hsa04922	0.37977129
82	Ether lipid metabolism_Homo sapiens_hsa00565	0.35665283
83	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.35566989
84	Base excision repair_Homo sapiens_hsa03410	0.34269766
85	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.29102767
86	Mineral absorption_Homo sapiens_hsa04978	0.28449959
87	AMPK signaling pathway_Homo sapiens_hsa04152	0.21254852
88	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.16780819
89	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.16486124
90	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.15359356
91	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.14989840
92	Mismatch repair_Homo sapiens_hsa03430	0.13272502
93	Circadian rhythm_Homo sapiens_hsa04710	0.12279277
94	ECM-receptor interaction_Homo sapiens_hsa04512	0.10485585
95	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.10387560
96	Pertussis_Homo sapiens_hsa05133	0.09559740
97	Lysosome_Homo sapiens_hsa04142	0.09062084
98	Prion diseases_Homo sapiens_hsa05020	0.08048705
99	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.08028423
100	Legionellosis_Homo sapiens_hsa05134	0.07772439
101	Pyrimidine metabolism_Homo sapiens_hsa00240	0.06445979
102	Primary immunodeficiency_Homo sapiens_hsa05340	0.06247225
103	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.05946557
104	Insulin resistance_Homo sapiens_hsa04931	0.01320535
105	Measles_Homo sapiens_hsa05162	-0.1163535
106	NF-kappa B signaling pathway_Homo sapiens_hsa04064	-0.0979411
107	Regulation of autophagy_Homo sapiens_hsa04140	-0.0908109
108	Adipocytokine signaling pathway_Homo sapiens_hsa04920	-0.0797482
109	Hepatitis C_Homo sapiens_hsa05160	-0.0754217
110	DNA replication_Homo sapiens_hsa03030	-0.0743970
111	Graft-versus-host disease_Homo sapiens_hsa05332	-0.0741252
112	African trypanosomiasis_Homo sapiens_hsa05143	-0.0726922
113	Fanconi anemia pathway_Homo sapiens_hsa03460	-0.0525656
114	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	-0.0387647
115	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	-0.0359335
116	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	-0.0341659
117	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	-0.0095924

SOAT2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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