SOCS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.28167018
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.28167018
3antigen processing and presentation of endogenous antigen (GO:0019883)5.57152585
4positive regulation of gamma-delta T cell activation (GO:0046645)5.52565259
5regulation of vitamin D biosynthetic process (GO:0060556)5.30963034
6regulation of gamma-delta T cell differentiation (GO:0045586)4.96463139
7regulation of gamma-delta T cell activation (GO:0046643)4.77610277
8T cell migration (GO:0072678)4.56319268
9negative regulation of interleukin-12 production (GO:0032695)4.47788615
10* response to type I interferon (GO:0034340)4.44947283
11* cellular response to type I interferon (GO:0071357)4.43753347
12* type I interferon signaling pathway (GO:0060337)4.43753347
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.42739721
14NIK/NF-kappaB signaling (GO:0038061)4.37871796
15regulation of cytokine secretion involved in immune response (GO:0002739)4.33253572
16response to interleukin-15 (GO:0070672)4.32123065
17positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.30762875
18negative T cell selection (GO:0043383)4.26586764
19regulation of interleukin-12 biosynthetic process (GO:0045075)4.26103926
20regulation of vitamin metabolic process (GO:0030656)4.25413165
21positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.19799288
22positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.19596403
23negative thymic T cell selection (GO:0045060)4.13376668
24leukocyte aggregation (GO:0070486)4.11716772
25positive thymic T cell selection (GO:0045059)4.11677591
26cellular response to interleukin-15 (GO:0071350)4.10743744
27interferon-gamma production (GO:0032609)4.07926868
28tolerance induction (GO:0002507)3.99395156
29positive regulation of type 2 immune response (GO:0002830)3.88796717
30regulation of dendritic cell antigen processing and presentation (GO:0002604)3.88686738
31thymic T cell selection (GO:0045061)3.88316092
32negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.86343616
33negative regulation of cell killing (GO:0031342)3.86343616
34lipopolysaccharide-mediated signaling pathway (GO:0031663)3.78373647
35T cell selection (GO:0045058)3.76652795
36defense response to protozoan (GO:0042832)3.74885717
37regulation of isotype switching to IgG isotypes (GO:0048302)3.74701274
38germinal center formation (GO:0002467)3.72215725
39negative regulation of viral genome replication (GO:0045071)3.70883030
40* regulation of type I interferon-mediated signaling pathway (GO:0060338)3.69526946
41negative regulation of cytokine production involved in immune response (GO:0002719)3.69147520
42positive regulation of heat generation (GO:0031652)3.67448606
43immunoglobulin mediated immune response (GO:0016064)3.66859432
44regulation of fever generation (GO:0031620)3.65216042
45T-helper 1 type immune response (GO:0042088)3.63846828
46positive T cell selection (GO:0043368)3.61322628
47regulation of immunoglobulin secretion (GO:0051023)3.57437117
48myeloid dendritic cell differentiation (GO:0043011)3.56629219
49branching involved in labyrinthine layer morphogenesis (GO:0060670)3.54275309
50response to protozoan (GO:0001562)3.53880283
51regulation of podosome assembly (GO:0071801)3.53057788
52regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.50305503
53* interferon-gamma-mediated signaling pathway (GO:0060333)3.45076488
54T cell receptor signaling pathway (GO:0050852)3.43373106
55positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.42934090
56positive regulation of interferon-alpha production (GO:0032727)3.42634990
57activation of MAPKKK activity (GO:0000185)3.40241240
58* JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.39064750
59CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.38798692
60modulation by symbiont of host defense response (GO:0052031)3.37235046
61modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.37235046
62modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.37235046
63positive regulation by organism of defense response of other organism involved in symbiotic interact3.37235046
64modulation by symbiont of host immune response (GO:0052553)3.37235046
65positive regulation by symbiont of host defense response (GO:0052509)3.37235046
66lymphocyte costimulation (GO:0031294)3.36913458
67positive regulation of isotype switching (GO:0045830)3.36441745
68myeloid dendritic cell activation (GO:0001773)3.34150591
69regulation of interleukin-12 production (GO:0032655)3.33929978
70T cell costimulation (GO:0031295)3.33828744
71dendritic cell differentiation (GO:0097028)3.33109545
72positive regulation of interleukin-2 production (GO:0032743)3.32111076
73regulation of interferon-alpha production (GO:0032647)3.32080034
74regulation of antigen processing and presentation (GO:0002577)3.31254997
75macrophage activation involved in immune response (GO:0002281)3.31205881
76regulation of B cell receptor signaling pathway (GO:0050855)3.30663632
77positive regulation of antigen processing and presentation (GO:0002579)3.29019110
78antigen processing and presentation via MHC class Ib (GO:0002475)3.28981877
79regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.27549955
80positive regulation of T-helper cell differentiation (GO:0045624)3.27298658
81regulation of alpha-beta T cell proliferation (GO:0046640)3.26502551
82positive regulation of immunoglobulin mediated immune response (GO:0002891)3.20582806
83positive regulation of B cell mediated immunity (GO:0002714)3.20582806
84* regulation of response to interferon-gamma (GO:0060330)3.19791488
85positive regulation of natural killer cell differentiation (GO:0032825)3.19232735
86cellular response to interferon-beta (GO:0035458)3.18485550
87regulation of type 2 immune response (GO:0002828)3.17957893
88response to muramyl dipeptide (GO:0032495)3.14375757
89positive regulation of chemokine biosynthetic process (GO:0045080)3.11395302
90CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.10570120
91T-helper cell differentiation (GO:0042093)3.10570120
92positive regulation of defense response to virus by host (GO:0002230)3.10436777
93antigen receptor-mediated signaling pathway (GO:0050851)3.10201036
94negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.09514321
95negative regulation of myeloid cell apoptotic process (GO:0033033)3.08907959
96* cellular response to interferon-gamma (GO:0071346)3.08276689
97regulation of interleukin-2 biosynthetic process (GO:0045076)3.07168877
98regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.07005539
99positive regulation of NF-kappaB import into nucleus (GO:0042346)3.06490137
100cellular response to virus (GO:0098586)3.06304180
101regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.06224595
102tyrosine phosphorylation of STAT protein (GO:0007260)3.06095908
103regulation of T-helper 2 cell differentiation (GO:0045628)3.05841789
104* regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.04992703
105alpha-beta T cell activation (GO:0046631)3.04794104
106lymphocyte chemotaxis (GO:0048247)3.04405918
107B cell mediated immunity (GO:0019724)3.04319884
108regulation of T cell receptor signaling pathway (GO:0050856)3.03306529
109positive regulation of interleukin-12 production (GO:0032735)3.03294491
110regulation of interferon-beta biosynthetic process (GO:0045357)3.02941847
111positive regulation of humoral immune response (GO:0002922)3.02775750
112natural killer cell activation (GO:0030101)3.02407463
113positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.02070145
114regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.01796909
115Arp2/3 complex-mediated actin nucleation (GO:0034314)3.01720468
116natural killer cell differentiation (GO:0001779)2.99041186
117regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.97216067
118regulation of T cell tolerance induction (GO:0002664)2.96408734
119positive regulation of alpha-beta T cell proliferation (GO:0046641)2.96110379
120response to interferon-alpha (GO:0035455)2.95338984
121alpha-beta T cell differentiation (GO:0046632)2.93746963
122positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.93600325
123regulation of interferon-gamma biosynthetic process (GO:0045072)2.93448155
124* response to interferon-gamma (GO:0034341)2.92962825
125positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.92411395
126positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.92406980
127regulation of T-helper 1 cell differentiation (GO:0045625)2.91251644
128regulation of membrane protein ectodomain proteolysis (GO:0051043)2.90529638
129positive regulation of interferon-beta production (GO:0032728)2.89827433
130negative regulation of production of molecular mediator of immune response (GO:0002701)2.89608884
131cellular response to interferon-alpha (GO:0035457)2.89418785
132negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.89119169
133regulation of inflammatory response to antigenic stimulus (GO:0002861)2.88198372
134positive regulation of interleukin-17 production (GO:0032740)2.88170817
135positive regulation of macrophage differentiation (GO:0045651)2.88151647
136response to interferon-beta (GO:0035456)2.87965283
137response to peptidoglycan (GO:0032494)2.87738948
138negative regulation of T cell mediated immunity (GO:0002710)2.87301319
139lymphocyte migration (GO:0072676)2.86854848
140alpha-beta T cell differentiation involved in immune response (GO:0002293)2.86661714
141alpha-beta T cell activation involved in immune response (GO:0002287)2.86661714
142T cell differentiation involved in immune response (GO:0002292)2.86661714
143regulation of RIG-I signaling pathway (GO:0039535)2.86122602
144regulation of NF-kappaB import into nucleus (GO:0042345)2.85210662
145regulation of T-helper 1 type immune response (GO:0002825)2.84935040
146positive regulation of cytokine biosynthetic process (GO:0042108)2.84832458
147negative regulation of type I interferon production (GO:0032480)2.84600552
148regulation of T-helper cell differentiation (GO:0045622)2.84589293
149negative regulation of nitric oxide biosynthetic process (GO:0045019)2.84355723
150positive regulation of DNA recombination (GO:0045911)2.84269626
151regulation of chemokine biosynthetic process (GO:0045073)2.84130983
152regulation of chronic inflammatory response (GO:0002676)2.83946542
153cellular response to lipopolysaccharide (GO:0071222)2.83707622

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.30699006
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.13370447
3* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.33888230
4* IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.14279416
5* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.99599599
6* IRF8_21731497_ChIP-ChIP_J774_Mouse3.92341921
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.60542249
8* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.28426944
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.19990238
10BP1_19119308_ChIP-ChIP_Hs578T_Human3.19616157
11MYC_22102868_ChIP-Seq_BL_Human2.94817600
12E2F7_22180533_ChIP-Seq_HELA_Human2.93142347
13* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.90059388
14* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.84346867
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.71989735
16MYB_26560356_Chip-Seq_TH2_Human2.64159321
17* MAF_26560356_Chip-Seq_TH1_Human2.56850543
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.54102987
19* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.42470112
20* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.41474089
21* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.41043306
22VDR_21846776_ChIP-Seq_THP-1_Human2.38406243
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.36735763
24MYB_21317192_ChIP-Seq_ERMYB_Mouse2.27686122
25UTX_26944678_Chip-Seq_JUKART_Human2.23167730
26* MYB_26560356_Chip-Seq_TH1_Human2.19678637
27* RUNX_20019798_ChIP-Seq_JUKART_Human2.19306528
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.98209545
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.97799511
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.96682410
31* RUNX1_22412390_ChIP-Seq_EML_Mouse1.94859330
32VDR_24763502_ChIP-Seq_THP-1_Human1.90670725
33* TCF7_22412390_ChIP-Seq_EML_Mouse1.89800396
34SPI1_23547873_ChIP-Seq_NB4_Human1.88422917
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.84599799
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.82561359
37MAF_26560356_Chip-Seq_TH2_Human1.79797675
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.75390575
39* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.72194507
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.65240977
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.60849322
42SCL_19346495_ChIP-Seq_HPC-7_Human1.60552471
43E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.59013832
44KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.58693634
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.56538747
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55697294
47GATA3_27048872_Chip-Seq_THYMUS_Human1.54159859
48* KDM2B_26808549_Chip-Seq_DND41_Human1.53939944
49TP63_17297297_ChIP-ChIP_HaCaT_Human1.53379972
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45409722
51EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.44533041
52* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.42502138
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.41174206
54VDR_24787735_ChIP-Seq_THP-1_Human1.40061176
55FOXM1_23109430_ChIP-Seq_U2OS_Human1.34998930
56CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33303226
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.31186242
58SPI1_23127762_ChIP-Seq_K562_Human1.30146290
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27041633
60PU_27001747_Chip-Seq_BMDM_Mouse1.23979387
61STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21651101
62CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21113227
63PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16662225
64LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15385614
65TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15205760
66VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.14811231
67ELF1_17652178_ChIP-ChIP_JURKAT_Human1.14509178
68* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13522313
69GATA3_26560356_Chip-Seq_TH2_Human1.04394495
70* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04014099
71BCOR_27268052_Chip-Seq_Bcells_Human1.03279222
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03009074
73Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.02773940
74* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01586377
75* ELF1_20517297_ChIP-Seq_JURKAT_Human1.01248486
76CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01185153
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00614901
78GATA1_22025678_ChIP-Seq_K562_Human0.99212855
79SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98547912
80LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96601551
81PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96591077
82* BCL6_27268052_Chip-Seq_Bcells_Human0.96394344
83VDR_23849224_ChIP-Seq_CD4+_Human0.95911514
84STAT1_20625510_ChIP-Seq_HELA_Human0.95755460
85FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.95673394
86SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95041625
87KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.94846631
88KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.94846631
89KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.94846631
90VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94405483
91EGR1_19032775_ChIP-ChIP_M12_Human0.93487312
92GATA1_19941826_ChIP-Seq_K562_Human0.92351076
93PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91569503
94RARG_19884340_ChIP-ChIP_MEFs_Mouse0.90714500
95* KDM2B_26808549_Chip-Seq_JURKAT_Human0.90200885
96CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89821477
97* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89148222
98NCOR1_26117541_ChIP-Seq_K562_Human0.88951297
99ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88839313
100STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87958730
101HOXB4_20404135_ChIP-ChIP_EML_Mouse0.87521177
102GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87219974
103SA1_27219007_Chip-Seq_ERYTHROID_Human0.86962603
104CTCF_27219007_Chip-Seq_ERYTHROID_Human0.85681935
105CIITA_25753668_ChIP-Seq_RAJI_Human0.85112043
106PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84133250
107RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.80556433
108SMAD_19615063_ChIP-ChIP_OVARY_Human0.80531710
109NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.79517102
110E2F4_17652178_ChIP-ChIP_JURKAT_Human0.79111956
111TFEB_21752829_ChIP-Seq_HELA_Human0.78841367
112NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.77962364
113LXR_22292898_ChIP-Seq_THP-1_Human0.77863585
114RACK7_27058665_Chip-Seq_MCF-7_Human0.77690306
115* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.77537852
116TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75667085
117GATA1_19941827_ChIP-Seq_MEL_Mouse0.69940836
118FOXP3_21729870_ChIP-Seq_TREG_Human0.69679520
119* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.69537283

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.03365483
2MP0005671_abnormal_response_to3.71032210
3MP0000685_abnormal_immune_system3.66968098
4MP0003763_abnormal_thymus_physiology3.48421818
5MP0003436_decreased_susceptibility_to3.34710866
6MP0001790_abnormal_immune_system3.30253898
7MP0005387_immune_system_phenotype3.30253898
8* MP0009785_altered_susceptibility_to3.27599729
9MP0006082_CNS_inflammation3.25847273
10MP0001800_abnormal_humoral_immune3.10818290
11* MP0005000_abnormal_immune_tolerance3.08354051
12MP0003303_peritoneal_inflammation3.04488641
13* MP0002723_abnormal_immune_serum2.77320505
14* MP0005025_abnormal_response_to2.76044071
15MP0003724_increased_susceptibility_to2.70304736
16* MP0002452_abnormal_antigen_presenting2.69549271
17* MP0001819_abnormal_immune_cell2.58038095
18* MP0002420_abnormal_adaptive_immunity2.57235037
19MP0009333_abnormal_splenocyte_physiolog2.50893760
20MP0002166_altered_tumor_susceptibility2.46429946
21MP0002148_abnormal_hypersensitivity_rea2.42976352
22MP0002405_respiratory_system_inflammati2.42961112
23* MP0002398_abnormal_bone_marrow2.42410092
24MP0005451_abnormal_body_composition2.27366311
25MP0002006_tumorigenesis2.25558415
26* MP0002419_abnormal_innate_immunity2.25174743
27* MP0000716_abnormal_immune_system2.18309106
28* MP0010155_abnormal_intestine_physiology2.15450444
29* MP0004947_skin_inflammation2.15034171
30MP0003300_gastrointestinal_ulcer2.05030012
31* MP0002722_abnormal_immune_system1.96564545
32MP0002139_abnormal_hepatobiliary_system1.95358770
33MP0001873_stomach_inflammation1.92224371
34* MP0000703_abnormal_thymus_morphology1.90077908
35* MP0000689_abnormal_spleen_morphology1.87158352
36MP0004808_abnormal_hematopoietic_stem1.86802389
37* MP0001845_abnormal_inflammatory_respons1.83718037
38* MP0002429_abnormal_blood_cell1.79780676
39MP0001533_abnormal_skeleton_physiology1.78663777
40* MP0004510_myositis1.77062355
41MP0005464_abnormal_platelet_physiology1.72996458
42MP0009278_abnormal_bone_marrow1.72161122
43MP0003866_abnormal_defecation1.69421712
44MP0008004_abnormal_stomach_pH1.67964726
45MP0002396_abnormal_hematopoietic_system1.65946559
46MP0003448_altered_tumor_morphology1.58363622
47* MP0005310_abnormal_salivary_gland1.57173289
48MP0002933_joint_inflammation1.52451435
49MP0005397_hematopoietic_system_phenotyp1.45553404
50MP0001545_abnormal_hematopoietic_system1.45553404
51* MP0008469_abnormal_protein_level1.37149084
52MP0010352_gastrointestinal_tract_polyps1.35797437
53MP0000858_altered_metastatic_potential1.35086578
54MP0002332_abnormal_exercise_endurance1.33939026
55MP0010307_abnormal_tumor_latency1.33829699
56* MP0001853_heart_inflammation1.28629215
57MP0005076_abnormal_cell_differentiation1.26364241
58MP0001348_abnormal_lacrimal_gland1.21656643
59MP0002998_abnormal_bone_remodeling1.20038260
60MP0000490_abnormal_crypts_of1.15016412
61MP0009840_abnormal_foam_cell1.14392416
62MP0009764_decreased_sensitivity_to1.10904502
63MP0005167_abnormal_blood-brain_barrier1.10379143
64MP0002138_abnormal_hepatobiliary_system1.02862124
65MP0006054_spinal_hemorrhage1.02510612
66MP0000343_altered_response_to0.98880584
67MP0005023_abnormal_wound_healing0.97285439
68MP0003806_abnormal_nucleotide_metabolis0.96387621
69* MP0002019_abnormal_tumor_incidence0.95233594
70MP0000465_gastrointestinal_hemorrhage0.94879190
71MP0001542_abnormal_bone_strength0.93669025
72MP0005058_abnormal_lysosome_morphology0.89602330
73MP0005390_skeleton_phenotype0.88133444
74MP0003453_abnormal_keratinocyte_physiol0.85365762
75MP0005166_decreased_susceptibility_to0.84547827
76* MP0001851_eye_inflammation0.84228929
77MP0003693_abnormal_embryo_hatching0.80290092
78MP0003195_calcinosis0.80194699
79MP0001501_abnormal_sleep_pattern0.79386781
80MP0003690_abnormal_glial_cell0.76261694
81MP0000604_amyloidosis0.75471773
82MP0003656_abnormal_erythrocyte_physiolo0.75460371
83MP0005666_abnormal_adipose_tissue0.75165189
84MP0004381_abnormal_hair_follicle0.74759830
85MP0002277_abnormal_respiratory_mucosa0.74279812
86MP0003045_fibrosis0.73985242
87* MP0009763_increased_sensitivity_to0.72250677
88MP0008874_decreased_physiological_sensi0.70704931
89MP0003077_abnormal_cell_cycle0.70330611
90MP0003191_abnormal_cellular_cholesterol0.69379556
91MP0003795_abnormal_bone_structure0.68456335
92MP0000249_abnormal_blood_vessel0.66678738
93MP0002132_abnormal_respiratory_system0.65444291
94MP0003566_abnormal_cell_adhesion0.62380729
95MP0002254_reproductive_system_inflammat0.61847856
96MP0001663_abnormal_digestive_system0.60751315
97MP0003172_abnormal_lysosome_physiology0.60433224
98MP0005410_abnormal_fertilization0.59643387
99MP0005535_abnormal_body_temperature0.58900934
100MP0003091_abnormal_cell_migration0.57662980
101MP0005647_abnormal_sex_gland0.57358568
102MP0008260_abnormal_autophagy0.57116061
103MP0003075_altered_response_to0.56315184
104MP0000313_abnormal_cell_death0.55531268
105MP0005381_digestive/alimentary_phenotyp0.55482085
106MP0000477_abnormal_intestine_morphology0.54745780
107MP0003646_muscle_fatigue0.54518780
108MP0001881_abnormal_mammary_gland0.53247062
109MP0008007_abnormal_cellular_replicative0.53094872
110* MP0002693_abnormal_pancreas_physiology0.52576625
111MP0005174_abnormal_tail_pigmentation0.51385502
112MP0004883_abnormal_blood_vessel0.49866635
113MP0001727_abnormal_embryo_implantation0.49446049
114MP0008057_abnormal_DNA_replication0.48697975
115MP0003111_abnormal_nucleus_morphology0.48568399
116MP0000627_abnormal_mammary_gland0.47314461
117* MP0002136_abnormal_kidney_physiology0.47044383
118* MP0000609_abnormal_liver_physiology0.46889450
119MP0005075_abnormal_melanosome_morpholog0.46760295
120MP0001191_abnormal_skin_condition0.44946501
121MP0001243_abnormal_dermal_layer0.44664686
122MP0008873_increased_physiological_sensi0.44195183
123* MP0009765_abnormal_xenobiotic_induced0.43366871
124MP0005164_abnormal_response_to0.42677766

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.72319084
2Eczematoid dermatitis (HP:0000976)5.48053316
3Nasal polyposis (HP:0100582)5.02273247
4Recurrent fungal infections (HP:0002841)4.86748779
5T lymphocytopenia (HP:0005403)4.84181646
6Abnormality of T cell number (HP:0011839)4.80269572
7Chronic otitis media (HP:0000389)4.76401003
8Abnormality of glycolipid metabolism (HP:0010969)4.70786801
9Abnormality of liposaccharide metabolism (HP:0010968)4.70786801
10Abnormality of glycosphingolipid metabolism (HP:0004343)4.70786801
11Myositis (HP:0100614)4.62368564
12Stomatitis (HP:0010280)4.56353236
13Recurrent bronchitis (HP:0002837)4.49413831
14Severe combined immunodeficiency (HP:0004430)4.46136940
15Recurrent viral infections (HP:0004429)4.40832569
16Abnormality of the nasal mucosa (HP:0000433)4.35384161
17Systemic lupus erythematosus (HP:0002725)4.27181444
18Recurrent abscess formation (HP:0002722)4.23112470
19Abnormality of T cells (HP:0002843)4.18417357
20Combined immunodeficiency (HP:0005387)4.03770152
21Orchitis (HP:0100796)4.02645222
22Chronic mucocutaneous candidiasis (HP:0002728)3.98269406
23Recurrent cutaneous fungal infections (HP:0011370)3.98269406
24Optic neuritis (HP:0100653)3.85622489
25Retrobulbar optic neuritis (HP:0100654)3.85622489
26Mediastinal lymphadenopathy (HP:0100721)3.82133819
27Increased IgM level (HP:0003496)3.72691003
28Recurrent bacterial skin infections (HP:0005406)3.70164504
29B lymphocytopenia (HP:0010976)3.66999063
30Abnormality of B cell number (HP:0010975)3.66999063
31Vacuolated lymphocytes (HP:0001922)3.66243118
32Loss of speech (HP:0002371)3.64422912
33IgM deficiency (HP:0002850)3.61203052
34Vasculitis (HP:0002633)3.57688387
35Panhypogammaglobulinemia (HP:0003139)3.56371094
36Autoimmune thrombocytopenia (HP:0001973)3.52166110
37IgG deficiency (HP:0004315)3.51999804
38Abnormality of T cell physiology (HP:0011840)3.43971857
39Thyroiditis (HP:0100646)3.42749958
40Abnormality of eosinophils (HP:0001879)3.39763402
41Dysostosis multiplex (HP:0000943)3.37933394
42Leukocytosis (HP:0001974)3.35094707
43Recurrent skin infections (HP:0001581)3.31064376
44Abnormality of macrophages (HP:0004311)3.22421998
45Eosinophilia (HP:0001880)3.22360320
46Pustule (HP:0200039)3.22121006
47Abnormal delayed hypersensitivity skin test (HP:0002963)3.22010768
48Gangrene (HP:0100758)3.04884053
49Chronic obstructive pulmonary disease (HP:0006510)3.01817350
50Obstructive lung disease (HP:0006536)3.01817350
51Meningitis (HP:0001287)2.99366581
52Autoimmune hemolytic anemia (HP:0001890)2.97663896
53Hypergammaglobulinemia (HP:0010702)2.97398733
54Increased IgE level (HP:0003212)2.97033030
55Pulmonary infiltrates (HP:0002113)2.92535635
56Lymphopenia (HP:0001888)2.90648915
57Abnormality of cells of the lymphoid lineage (HP:0012140)2.88258866
58Disinhibition (HP:0000734)2.85428659
59Granulocytopenia (HP:0001913)2.83716392
60Gastrointestinal infarctions (HP:0005244)2.80305581
61Nuclear cataract (HP:0100018)2.77909226
62Increased density of long bones (HP:0006392)2.77553524
63Petechiae (HP:0000967)2.76122221
64Hemoptysis (HP:0002105)2.75720219
65IgA deficiency (HP:0002720)2.72292863
66Recurrent gram-negative bacterial infections (HP:0005420)2.71789000
67Chronic diarrhea (HP:0002028)2.69260263
68Cellulitis (HP:0100658)2.65166751
69Gingivitis (HP:0000230)2.62967085
70Arterial thrombosis (HP:0004420)2.62565128
71Increased serum ferritin (HP:0003281)2.61110293
72Emphysema (HP:0002097)2.60535971
73Parakeratosis (HP:0001036)2.52147179
74Chronic sinusitis (HP:0011109)2.51555198
75Interstitial pulmonary disease (HP:0006530)2.49842620
76Joint swelling (HP:0001386)2.49586334
77Abnormality of the fingertips (HP:0001211)2.48796081
78Lymphoma (HP:0002665)2.48293921
79Progressive neurologic deterioration (HP:0002344)2.47176179
80Glomerulonephritis (HP:0000099)2.45642224
81Keratoconjunctivitis sicca (HP:0001097)2.45518026
82Abnormality of polysaccharide metabolism (HP:0011012)2.45315388
83Abnormality of glycosaminoglycan metabolism (HP:0004371)2.45315388
84Abnormality of mucopolysaccharide metabolism (HP:0011020)2.45315388
85Inflammation of the large intestine (HP:0002037)2.44725897
86Bronchitis (HP:0012387)2.43828201
87Increased neuronal autofluorescent lipopigment (HP:0002074)2.43551299
88Basal ganglia calcification (HP:0002135)2.42679305
89Gastrointestinal inflammation (HP:0004386)2.41504464
90Mutism (HP:0002300)2.38780889
91Keratoconjunctivitis (HP:0001096)2.36886067
92Thrombocytosis (HP:0001894)2.34026725
93Polyneuropathy (HP:0001271)2.32883977
94Spontaneous hematomas (HP:0007420)2.32120336
95Mucopolysacchariduria (HP:0008155)2.32044374
96Urinary glycosaminoglycan excretion (HP:0003541)2.32044374
97Gastrointestinal stroma tumor (HP:0100723)2.26753830
98Cheilitis (HP:0100825)2.26475313
99Hypoplasia of the thymus (HP:0000778)2.25822967
100Gingival bleeding (HP:0000225)2.24866168
101Anorexia (HP:0002039)2.22379183
102Hematochezia (HP:0002573)2.21665346
103Encephalitis (HP:0002383)2.21574612
104Glomerulopathy (HP:0100820)2.14828869
105Periodontitis (HP:0000704)2.14671072
106Acne (HP:0001061)2.12465054
107Skin ulcer (HP:0200042)2.11279598
108Chest pain (HP:0100749)2.10709506
109Restrictive lung disease (HP:0002091)2.10220273
110Agammaglobulinemia (HP:0004432)2.09373813
111Abnormality of the pericardium (HP:0001697)2.03759098
112Premature loss of primary teeth (HP:0006323)2.02721367
113Epistaxis (HP:0000421)1.99792086
114Urticaria (HP:0001025)1.99466609
115Hepatosplenomegaly (HP:0001433)1.98423485
116Hypertensive crisis (HP:0100735)1.97865927
117Abnormality of iron homeostasis (HP:0011031)1.97832899
118Recurrent sinusitis (HP:0011108)1.96623999
119Prolonged bleeding time (HP:0003010)1.94905614
120Arthralgia (HP:0002829)1.94399756
121Porencephaly (HP:0002132)1.91664392
122Pulmonary embolism (HP:0002204)1.88450357
123Colitis (HP:0002583)1.83724717
124Abnormality of the pleura (HP:0002103)1.81210995
125Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.80950958
126Impaired platelet aggregation (HP:0003540)1.80871308
127Abnormal platelet function (HP:0011869)1.80871308
128Osteomyelitis (HP:0002754)1.80795336
129Increased cerebral lipofuscin (HP:0011813)1.80427565
130Purpura (HP:0000979)1.79583265
131Persistence of primary teeth (HP:0006335)1.79411182

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.91430068
2TXK4.34833103
3TYK23.40489286
4JAK33.23403532
5IKBKE3.19715544
6FGFR42.98853402
7GRK72.97026252
8TBK12.96026792
9PRPF4B2.91800514
10TAOK22.88277541
11ZAP702.80524345
12MAP3K142.74170450
13RIPK12.42410427
14BLK2.39066403
15DDR22.38666332
16JAK12.26319899
17PIM22.13186007
18MATK2.05077009
19IKBKB1.99681210
20MAP3K101.97316782
21ERN11.90819089
22EEF2K1.89170406
23IRAK41.85865236
24KIT1.84663168
25FGFR31.71901360
26ITK1.67916276
27STK101.62065251
28GRK61.60602653
29MOS1.59971838
30CHUK1.59399318
31TESK21.56685976
32EPHB11.55882620
33RPS6KA41.54498234
34NLK1.47122813
35LCK1.46533490
36IRAK31.45610300
37SYK1.45074113
38EPHA31.41172042
39PIM11.40298193
40KDR1.37740191
41HCK1.36025287
42BTK1.32411156
43CDC42BPA1.32215402
44CSK1.21605931
45NME21.20377414
46FGR1.19865535
47BMPR21.18808800
48TRIB31.18676290
49MAP3K131.16773138
50TEC1.15179632
51SMG11.13960036
52RIPK41.07661316
53ADRBK21.00733056
54JAK20.98582677
55TYRO30.96545852
56LRRK20.95538333
57RPS6KA50.94749095
58MST40.94643568
59PKN20.89663697
60IRAK10.84988425
61CDK120.80907605
62LYN0.79327881
63MAP3K110.75658948
64MAP2K30.73526085
65TAOK10.71984490
66SIK20.70570102
67TAOK30.69423630
68MARK30.69195572
69CLK10.66967295
70SIK30.65659758
71STK40.61862385
72HIPK20.61222207
73TESK10.60380416
74ALK0.59819970
75RAF10.58380958
76FES0.58283696
77CDK40.58173349
78CSF1R0.57506950
79PBK0.55030171
80DYRK30.53761107
81PRKCQ0.52174423
82PRKCH0.52020063
83TGFBR20.51684034
84MAP3K80.51401964
85MAP3K50.51065840
86BMX0.50187394
87NEK20.49461077
88PTK60.45916752
89ICK0.45559232
90TLK10.45269818
91PKN10.44012155
92RPS6KB20.41997661
93RPS6KA10.40873420
94SIK10.40753786
95MAP3K30.40177453
96ABL10.40095068
97RPS6KC10.39804018
98RPS6KL10.39804018
99TNK20.38793044
100MAPKAPK20.38180261
101MAPK70.37821649
102ARAF0.36043550
103PDGFRA0.35983112
104ABL20.35662332
105MAP3K10.33493437
106MAPK110.33075495
107EIF2AK20.31887514
108DAPK30.31027406
109CDK60.30657528
110PDGFRB0.30622992
111LATS20.30575683
112EIF2AK10.30073160
113TGFBR10.29878635
114ACVR1B0.29365155
115TSSK60.29352052
116RPS6KA60.28836638
117CDK90.28277558
118MAP2K60.26515738
119EGFR0.24875645
120PRKCD0.22789346
121STK240.22438238
122INSR0.21618634
123PDK10.21613359
124NEK90.21395696
125MAPK40.19916932
126MAPK30.19078417
127BUB10.17857265
128MAP3K120.17525630
129IRAK20.16639519

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.66962993
2Allograft rejection_Homo sapiens_hsa053303.12637201
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.04473163
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.81483269
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.74064357
6Asthma_Homo sapiens_hsa053102.73184350
7Measles_Homo sapiens_hsa051622.71865123
8Leishmaniasis_Homo sapiens_hsa051402.69908829
9T cell receptor signaling pathway_Homo sapiens_hsa046602.42086307
10Graft-versus-host disease_Homo sapiens_hsa053322.39844407
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.22727529
12Antigen processing and presentation_Homo sapiens_hsa046122.20746908
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.15141839
14* Osteoclast differentiation_Homo sapiens_hsa043802.11975789
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.99305003
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.98863411
17Herpes simplex infection_Homo sapiens_hsa051681.90288406
18Autoimmune thyroid disease_Homo sapiens_hsa053201.86258736
19* Jak-STAT signaling pathway_Homo sapiens_hsa046301.83998924
20Hematopoietic cell lineage_Homo sapiens_hsa046401.77608933
21TNF signaling pathway_Homo sapiens_hsa046681.70624982
22Influenza A_Homo sapiens_hsa051641.68822218
23Legionellosis_Homo sapiens_hsa051341.65261407
24B cell receptor signaling pathway_Homo sapiens_hsa046621.65208949
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.63156402
26* Toxoplasmosis_Homo sapiens_hsa051451.54502760
27Hepatitis B_Homo sapiens_hsa051611.49416260
28Malaria_Homo sapiens_hsa051441.46443134
29Apoptosis_Homo sapiens_hsa042101.44705133
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.40319917
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.36726605
32Shigellosis_Homo sapiens_hsa051311.36057095
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.35729407
34Viral myocarditis_Homo sapiens_hsa054161.35411738
35Acute myeloid leukemia_Homo sapiens_hsa052211.33704790
36Tuberculosis_Homo sapiens_hsa051521.31724732
37Pertussis_Homo sapiens_hsa051331.31545049
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.30759117
39Chemokine signaling pathway_Homo sapiens_hsa040621.30014517
40Type I diabetes mellitus_Homo sapiens_hsa049401.27071421
41Staphylococcus aureus infection_Homo sapiens_hsa051501.18095802
42Hepatitis C_Homo sapiens_hsa051601.11978162
43Chronic myeloid leukemia_Homo sapiens_hsa052201.05095761
44Salmonella infection_Homo sapiens_hsa051321.03145890
45HTLV-I infection_Homo sapiens_hsa051661.02616234
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02294529
47Epstein-Barr virus infection_Homo sapiens_hsa051691.02273636
48Viral carcinogenesis_Homo sapiens_hsa052031.00151242
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.93962213
50* Prolactin signaling pathway_Homo sapiens_hsa049170.92542969
51Pancreatic cancer_Homo sapiens_hsa052120.91579551
52Glycosaminoglycan degradation_Homo sapiens_hsa005310.86599267
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86546294
54Rheumatoid arthritis_Homo sapiens_hsa053230.86377756
55p53 signaling pathway_Homo sapiens_hsa041150.80985081
56African trypanosomiasis_Homo sapiens_hsa051430.79328879
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74371455
58Small cell lung cancer_Homo sapiens_hsa052220.72845002
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71504906
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70575850
61Bladder cancer_Homo sapiens_hsa052190.68964698
62VEGF signaling pathway_Homo sapiens_hsa043700.68731100
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65570826
64Ribosome_Homo sapiens_hsa030100.64781617
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63101341
66Notch signaling pathway_Homo sapiens_hsa043300.62129084
67Platelet activation_Homo sapiens_hsa046110.61632606
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.61554962
69Colorectal cancer_Homo sapiens_hsa052100.58504444
70Proteasome_Homo sapiens_hsa030500.57623273
71HIF-1 signaling pathway_Homo sapiens_hsa040660.57469836
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.54371635
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54043318
74Spliceosome_Homo sapiens_hsa030400.51827743
75DNA replication_Homo sapiens_hsa030300.47238080
76Lysosome_Homo sapiens_hsa041420.47013389
77FoxO signaling pathway_Homo sapiens_hsa040680.43400481
78Base excision repair_Homo sapiens_hsa034100.41909426
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40592430
80Amoebiasis_Homo sapiens_hsa051460.39915162
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.39691853
82Endocytosis_Homo sapiens_hsa041440.39673622
83Caffeine metabolism_Homo sapiens_hsa002320.36695103
84Other glycan degradation_Homo sapiens_hsa005110.36676059
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36421239
86MAPK signaling pathway_Homo sapiens_hsa040100.36054220
87* MicroRNAs in cancer_Homo sapiens_hsa052060.35673127
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33395882
89Sphingolipid metabolism_Homo sapiens_hsa006000.32062056
90Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.30556729
91Insulin resistance_Homo sapiens_hsa049310.29259775
92Cell cycle_Homo sapiens_hsa041100.29194387
93Fructose and mannose metabolism_Homo sapiens_hsa000510.29093930
94Non-small cell lung cancer_Homo sapiens_hsa052230.29004716
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28085149
96Phagosome_Homo sapiens_hsa041450.28064111
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27191490
98Sulfur metabolism_Homo sapiens_hsa009200.27003828
99Prion diseases_Homo sapiens_hsa050200.26878747
100Prostate cancer_Homo sapiens_hsa052150.26694551
101* Type II diabetes mellitus_Homo sapiens_hsa049300.25709456
102Proteoglycans in cancer_Homo sapiens_hsa052050.25628798
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25358812
104Complement and coagulation cascades_Homo sapiens_hsa046100.25304232
105Renal cell carcinoma_Homo sapiens_hsa052110.24647782
106Pathways in cancer_Homo sapiens_hsa052000.23747277
107Thyroid cancer_Homo sapiens_hsa052160.22841081
108mTOR signaling pathway_Homo sapiens_hsa041500.22020456
109Systemic lupus erythematosus_Homo sapiens_hsa053220.20879907
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.19498433
111Folate biosynthesis_Homo sapiens_hsa007900.18594811
112RNA degradation_Homo sapiens_hsa030180.17815116
113Galactose metabolism_Homo sapiens_hsa000520.17621463
114Endometrial cancer_Homo sapiens_hsa052130.16900933
115Dorso-ventral axis formation_Homo sapiens_hsa043200.12059969
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.10690184
117Renin-angiotensin system_Homo sapiens_hsa046140.05372332
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.00442571
119Vibrio cholerae infection_Homo sapiens_hsa05110-0.0188211

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