SOCS4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of centriole replication (GO:0046599)4.23608280
2positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.11148997
3positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.11148997
4positive regulation of mitotic sister chromatid separation (GO:1901970)4.11148997
5sister chromatid cohesion (GO:0007062)4.08778189
6snRNA transcription (GO:0009301)3.98156411
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.85557753
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.85557753
9regulation of sister chromatid cohesion (GO:0007063)3.81477801
10translesion synthesis (GO:0019985)3.79903899
11sister chromatid segregation (GO:0000819)3.61364957
12regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.60275360
13kinetochore organization (GO:0051383)3.58755736
14protein localization to endosome (GO:0036010)3.53851724
15definitive hemopoiesis (GO:0060216)3.47677031
16positive regulation of gamma-delta T cell activation (GO:0046645)3.41803737
17cellular protein complex localization (GO:0034629)3.37602358
18positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.35434935
19regulation of centrosome cycle (GO:0046605)3.35346880
20regulation of NFAT protein import into nucleus (GO:0051532)3.34985298
21regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.34358478
22magnesium ion transport (GO:0015693)3.33984915
23regulation of centrosome duplication (GO:0010824)3.33157311
24positive regulation of chromosome segregation (GO:0051984)3.32947046
25postreplication repair (GO:0006301)3.31309089
26antigen processing and presentation of endogenous antigen (GO:0019883)3.29949666
27mitotic chromosome condensation (GO:0007076)3.28594912
28metaphase plate congression (GO:0051310)3.25457762
29regulation of mitotic spindle organization (GO:0060236)3.23320651
30protein export from nucleus (GO:0006611)3.20262726
31mitotic sister chromatid segregation (GO:0000070)3.18245970
32atrial cardiac muscle cell action potential (GO:0086014)3.16349438
33keratinocyte development (GO:0003334)3.15447220
34regulation of interleukin-12 biosynthetic process (GO:0045075)3.14696471
35mitotic sister chromatid cohesion (GO:0007064)3.12351425
36ribosome assembly (GO:0042255)3.11816557
37peptidyl-threonine dephosphorylation (GO:0035970)3.11493022
38non-recombinational repair (GO:0000726)3.09008893
39double-strand break repair via nonhomologous end joining (GO:0006303)3.09008893
40mitotic metaphase plate congression (GO:0007080)3.08442990
41negative regulation of DNA repair (GO:0045738)3.08212065
42DNA-dependent DNA replication (GO:0006261)3.04346188
43regulation of gamma-delta T cell differentiation (GO:0045586)3.01471841
44cytoplasmic mRNA processing body assembly (GO:0033962)3.01452318
45regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.00459578
46regulation of mitotic metaphase/anaphase transition (GO:0030071)3.00459578
47regulation of extracellular matrix disassembly (GO:0010715)2.97936029
48pre-miRNA processing (GO:0031054)2.95875263
49meiotic chromosome segregation (GO:0045132)2.95495758
50regulation of establishment of cell polarity (GO:2000114)2.94950867
51membrane disassembly (GO:0030397)2.94770615
52nuclear envelope disassembly (GO:0051081)2.94770615
53nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.93652660
54regulation of RNA export from nucleus (GO:0046831)2.93169444
55ventricular trabecula myocardium morphogenesis (GO:0003222)2.93135503
56mitotic nuclear envelope disassembly (GO:0007077)2.92188368
57establishment of nucleus localization (GO:0040023)2.90798949
58DNA duplex unwinding (GO:0032508)2.90772198
59maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.89130533
60establishment of chromosome localization (GO:0051303)2.88682473
61nuclear pore complex assembly (GO:0051292)2.88018025
62cellular response to nerve growth factor stimulus (GO:1990090)2.87635719
63response to nerve growth factor (GO:1990089)2.87635719
64regulation of gamma-delta T cell activation (GO:0046643)2.87592673
65regulation of Rac protein signal transduction (GO:0035020)2.85890260
66regulation of mitotic sister chromatid separation (GO:0010965)2.85673352
67regulation of mitotic sister chromatid segregation (GO:0033047)2.85673352
68regulation of sister chromatid segregation (GO:0033045)2.85673352
69hepatocyte apoptotic process (GO:0097284)2.85157566
70DNA geometric change (GO:0032392)2.84851590
71energy homeostasis (GO:0097009)2.84781759
72kinetochore assembly (GO:0051382)2.83984145
73regulation of chromosome segregation (GO:0051983)2.81683837
74negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.79530640
75replication fork processing (GO:0031297)2.79440391
76rRNA methylation (GO:0031167)2.77606606
77spindle checkpoint (GO:0031577)2.75716775
78mitotic spindle organization (GO:0007052)2.74092671
79antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.68269305
80protein localization to chromosome (GO:0034502)2.68062905
81resolution of meiotic recombination intermediates (GO:0000712)2.67713977
82prenylation (GO:0097354)2.66361182
83protein prenylation (GO:0018342)2.66361182
84mitotic spindle checkpoint (GO:0071174)2.64357739
85microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.61685374
86protein complex localization (GO:0031503)2.61435982
87protein K6-linked ubiquitination (GO:0085020)2.61309923
88negative regulation of DNA-dependent DNA replication (GO:2000104)2.60244854
89DNA double-strand break processing (GO:0000729)2.60041069
90microtubule depolymerization (GO:0007019)2.58948582
91cellular glucuronidation (GO:0052695)2.57262676
92response to UV-C (GO:0010225)2.56966368
93negative regulation of neurotransmitter secretion (GO:0046929)2.56837383
94negative regulation of chromosome segregation (GO:0051985)2.56023803
95nucleus localization (GO:0051647)2.55858471
96regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.55584336
97glutamine metabolic process (GO:0006541)2.53170068
98somatic hypermutation of immunoglobulin genes (GO:0016446)2.52764112
99somatic diversification of immune receptors via somatic mutation (GO:0002566)2.52764112
100positive thymic T cell selection (GO:0045059)2.52065184
101gene silencing by RNA (GO:0031047)2.50441564
102negative regulation of mitotic sister chromatid segregation (GO:0033048)2.50373320
103negative regulation of sister chromatid segregation (GO:0033046)2.50373320
104histone mRNA catabolic process (GO:0071044)2.50173540
105dosage compensation (GO:0007549)2.47027939
106pore complex assembly (GO:0046931)2.42888451
107positive regulation of histone deacetylation (GO:0031065)2.39506467
108negative T cell selection (GO:0043383)2.35481726
109intestinal absorption (GO:0050892)2.31654863
110negative regulation of B cell proliferation (GO:0030889)2.31302728
111intestinal cholesterol absorption (GO:0030299)2.31259499
112negative thymic T cell selection (GO:0045060)2.30866913
113glucuronate metabolic process (GO:0019585)2.26533816
114uronic acid metabolic process (GO:0006063)2.26533816
115germ cell migration (GO:0008354)2.25702800
116interferon-gamma production (GO:0032609)2.25578537
117regulation of extracellular matrix organization (GO:1903053)2.25387786
118nuclear pore organization (GO:0006999)2.25304679
119neural tube formation (GO:0001841)2.24108308
120regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.24094019
121positive regulation of extracellular matrix organization (GO:1903055)2.21841295
122histone H3-K36 demethylation (GO:0070544)2.21568107
123UDP-N-acetylglucosamine metabolic process (GO:0006047)2.19642246
124positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.19345410
125B cell homeostasis (GO:0001782)2.18660185
126radial glial cell differentiation (GO:0060019)2.17916083
127regulation of nucleobase-containing compound transport (GO:0032239)2.17241530
128regulation of DNA endoreduplication (GO:0032875)2.14897140
129growth hormone receptor signaling pathway (GO:0060396)2.14497331
130plasma lipoprotein particle assembly (GO:0034377)2.14244457
131face development (GO:0060324)2.13433105
132DNA unwinding involved in DNA replication (GO:0006268)2.10168466
133protein localization to kinetochore (GO:0034501)2.10062327
134regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.08382236
135positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.08382236
136response to muramyl dipeptide (GO:0032495)2.07728743
137thymic T cell selection (GO:0045061)2.07162919
138mRNA stabilization (GO:0048255)2.05780359
139RNA stabilization (GO:0043489)2.05780359
140T cell apoptotic process (GO:0070231)2.04134672
141I-kappaB phosphorylation (GO:0007252)2.03881413
142regulation of B cell receptor signaling pathway (GO:0050855)2.03193758
143negative regulation of cell killing (GO:0031342)2.02938703
144negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.02938703
145response to nitrosative stress (GO:0051409)2.00582003
146positive regulation of isotype switching (GO:0045830)1.98939609
147positive regulation of p38MAPK cascade (GO:1900745)1.98913833
148protein-lipid complex assembly (GO:0065005)1.98060359
149positive T cell selection (GO:0043368)1.96969880
150negative regulation of histone methylation (GO:0031061)1.96223624
151protein localization to chromosome, centromeric region (GO:0071459)1.95735736
152regulation of spindle organization (GO:0090224)1.95683683
153positive regulation of mRNA catabolic process (GO:0061014)1.93755969
154negative regulation of thymocyte apoptotic process (GO:0070244)1.93551725
155positive regulation of interleukin-8 secretion (GO:2000484)1.93056490
156positive regulation of B cell differentiation (GO:0045579)1.92313353
157T cell differentiation in thymus (GO:0033077)1.92224047
158regulation of histone H3-K9 methylation (GO:0051570)1.91632334
159positive regulation of natural killer cell differentiation (GO:0032825)1.91236764
160T cell selection (GO:0045058)1.89941574
161JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)1.88747767
162negative regulation of bone resorption (GO:0045779)1.88530793
163positive regulation of type I interferon-mediated signaling pathway (GO:0060340)1.88025593
164negative regulation of alpha-beta T cell activation (GO:0046636)1.87545976
165coronary vasculature morphogenesis (GO:0060977)1.87365906
166lymphocyte homeostasis (GO:0002260)1.86795157
167positive regulation of blood vessel endothelial cell migration (GO:0043536)1.86246061
168myoblast differentiation (GO:0045445)1.86086493
169regulation of thymocyte apoptotic process (GO:0070243)1.85673565
170defense response to fungus (GO:0050832)1.85351197
171gland morphogenesis (GO:0022612)1.84687193
172regulation of cytokine secretion involved in immune response (GO:0002739)1.83618886
173regulation of protein polyubiquitination (GO:1902914)1.83489042
174tryptophan metabolic process (GO:0006568)1.82976700
175monoubiquitinated protein deubiquitination (GO:0035520)1.82590101
176lymphocyte apoptotic process (GO:0070227)1.82410681
177regulation of mRNA stability (GO:0043488)1.82045006
178T cell differentiation (GO:0030217)1.82011588
179very-low-density lipoprotein particle assembly (GO:0034379)1.81061525
180regulation of B cell differentiation (GO:0045577)1.80370060
181negative regulation of RNA splicing (GO:0033119)1.79157404
182natural killer cell differentiation (GO:0001779)1.78977428
183tyrosine phosphorylation of STAT protein (GO:0007260)1.78885448
184DNA topological change (GO:0006265)1.78614653

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.83232969
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.35732138
3RBPJ_22232070_ChIP-Seq_NCS_Mouse4.23397606
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.97160337
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.11682048
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.08491755
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.01647906
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.86022575
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.81393518
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.77637581
11MYC_22102868_ChIP-Seq_BL_Human2.51421192
12TAF15_26573619_Chip-Seq_HEK293_Human2.43341997
13* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.39533372
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.27677073
15* EWS_26573619_Chip-Seq_HEK293_Human2.25957069
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.25595538
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.22476778
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.18229898
19FUS_26573619_Chip-Seq_HEK293_Human2.08444901
20SCL_19346495_ChIP-Seq_HPC-7_Human2.05106854
21IGF1R_20145208_ChIP-Seq_DFB_Human2.00518315
22GATA1_22025678_ChIP-Seq_K562_Human2.00339598
23E2F4_17652178_ChIP-ChIP_JURKAT_Human1.98754010
24* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.97962343
25ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.94730570
26* GBX2_23144817_ChIP-Seq_PC3_Human1.94659251
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.90192237
28TP63_19390658_ChIP-ChIP_HaCaT_Human1.89989038
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.89521715
30* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84902038
31MYB_21317192_ChIP-Seq_ERMYB_Mouse1.82042395
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.81958535
33MYB_26560356_Chip-Seq_TH1_Human1.81416531
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81090566
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.80953209
36MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.79590112
37MYB_26560356_Chip-Seq_TH2_Human1.79578507
38PPARA_22158963_ChIP-Seq_LIVER_Mouse1.79289584
39EGR1_23403033_ChIP-Seq_LIVER_Mouse1.78067003
40RXR_22158963_ChIP-Seq_LIVER_Mouse1.77538174
41NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77283789
42AR_21909140_ChIP-Seq_LNCAP_Human1.76800570
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76298169
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.72765717
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68502484
46SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.65091640
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.63921911
48MYC_18555785_ChIP-Seq_MESCs_Mouse1.59605365
49VDR_21846776_ChIP-Seq_THP-1_Human1.59593087
50CLOCK_20551151_ChIP-Seq_293T_Human1.59220586
51LXR_22158963_ChIP-Seq_LIVER_Mouse1.58142122
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.56887350
53MAF_26560356_Chip-Seq_TH1_Human1.54013946
54IRF8_27001747_Chip-Seq_BMDM_Mouse1.53769323
55HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.53260407
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.52806448
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51024074
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.49673208
59TCF7_22412390_ChIP-Seq_EML_Mouse1.48669916
60RUNX_20019798_ChIP-Seq_JUKART_Human1.46845421
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46365892
62* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.46203656
63RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.46101305
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45658415
65STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.44117891
66TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.42689517
67KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.42131880
68UTX_26944678_Chip-Seq_JUKART_Human1.41720433
69ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41323781
70KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.40454390
71KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.40152545
72ZNF274_21170338_ChIP-Seq_K562_Hela1.39936254
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39122831
74KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.39046655
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38379388
76FOXO3_23340844_ChIP-Seq_DLD1_Human1.37666327
77* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.37308981
78TP53_16413492_ChIP-PET_HCT116_Human1.37098705
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36579455
80SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.36313583
81SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.36313583
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.33886479
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.33788597
84SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.32650070
85SALL1_21062744_ChIP-ChIP_HESCs_Human1.30089879
86WT1_19549856_ChIP-ChIP_CCG9911_Human1.30036821
87VDR_24763502_ChIP-Seq_THP-1_Human1.29748411
88TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.27004487
89ER_23166858_ChIP-Seq_MCF-7_Human1.26722486
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24062225
91* P300_19829295_ChIP-Seq_ESCs_Human1.23565609
92STAT4_19710469_ChIP-ChIP_TH1__Mouse1.22570425
93PU_27001747_Chip-Seq_BMDM_Mouse1.21658184
94RUNX1_22412390_ChIP-Seq_EML_Mouse1.20415322
95GABP_17652178_ChIP-ChIP_JURKAT_Human1.20329901
96CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.18217204
97PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16859083
98FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16666180
99SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.15815180
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15734096
101CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15005955
102TRIM28_21343339_ChIP-Seq_HEK293_Human1.14106754
103CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13455760
104SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13339995
105* SPI1_23547873_ChIP-Seq_NB4_Human1.13107014
106STAT3_23295773_ChIP-Seq_U87_Human1.12610757
107GATA6_25053715_ChIP-Seq_YYC3_Human1.11670689
108KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11635829
109SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11326602
110ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10952069
111Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.10911279
112VDR_23849224_ChIP-Seq_CD4+_Human1.10493849
113SALL4_18804426_ChIP-ChIP_XEN_Mouse1.10461491
114NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09362863
115NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09362863
116BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08363086
117RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08283148
118ELF1_17652178_ChIP-ChIP_JURKAT_Human1.07408450
119SOX2_16153702_ChIP-ChIP_HESCs_Human1.06719365
120SMAD4_21799915_ChIP-Seq_A2780_Human1.06038743
121MYC_18940864_ChIP-ChIP_HL60_Human1.05368263
122FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05140444
123CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03670692
124ELK1_19687146_ChIP-ChIP_HELA_Human1.03042092
125KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02490925
126NANOG_18555785_Chip-Seq_ESCs_Mouse1.02037849
127SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01876518
128* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.00858555
129EZH2_27294783_Chip-Seq_NPCs_Mouse1.00702311
130HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00671035
131GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00384940
132IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00273553
133CBP_20019798_ChIP-Seq_JUKART_Human1.00273553
134PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98929755
135SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97176572
136GATA3_27048872_Chip-Seq_THYMUS_Human0.97000309
137ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96743947
138NCOR1_26117541_ChIP-Seq_K562_Human0.96422365
139TP53_18474530_ChIP-ChIP_U2OS_Human0.96374731
140CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.95999439
141UBF1/2_26484160_Chip-Seq_HMECs_Human0.95847062
142MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.95697958
143PIAS1_25552417_ChIP-Seq_VCAP_Human0.95436067
144CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.95106800
145PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94782879
146SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94747714
147CHD1_26751641_Chip-Seq_LNCaP_Human0.94433756
148CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94291973
149E2F1_18555785_Chip-Seq_ESCs_Mouse0.93847451
150TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93072415
151TCF4_23295773_ChIP-Seq_U87_Human0.92912453
152EST1_17652178_ChIP-ChIP_JURKAT_Human0.92598070
153BRD4_25478319_ChIP-Seq_HGPS_Human0.92190755
154PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91864880
155TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91547739
156GATA4_25053715_ChIP-Seq_YYC3_Human0.91280642
157CREB1_15753290_ChIP-ChIP_HEK293T_Human0.91203391
158BP1_19119308_ChIP-ChIP_Hs578T_Human0.91108733
159CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90943184
160SOX9_26525672_Chip-Seq_HEART_Mouse0.90775539
161NFE2_27457419_Chip-Seq_LIVER_Mouse0.90550617
162TCF4_18268006_ChIP-ChIP_LS174T_Human0.90458649
163SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90087036
164POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89432189
165* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89334000
166NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.89157087
167EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89015030
168ELK3_25401928_ChIP-Seq_HUVEC_Human0.88456498
169PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.87336860
170UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86490444
171STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.86126067
172DCP1A_22483619_ChIP-Seq_HELA_Human0.85827065
173HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.85374798
174* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.85109135
175FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.83469765
176E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.82846915

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003890_abnormal_embryonic-extraembry3.09576400
2MP0003300_gastrointestinal_ulcer2.69926457
3MP0010352_gastrointestinal_tract_polyps2.52968468
4MP0009697_abnormal_copulation2.33293634
5MP0003705_abnormal_hypodermis_morpholog2.29570150
6MP0005360_urolithiasis2.06972284
7MP0002166_altered_tumor_susceptibility2.04695126
8MP0002009_preneoplasia1.89507991
9MP0003252_abnormal_bile_duct1.89377515
10MP0008932_abnormal_embryonic_tissue1.89144396
11MP0003221_abnormal_cardiomyocyte_apopto1.85211500
12MP0008058_abnormal_DNA_repair1.79929750
13MP0002396_abnormal_hematopoietic_system1.78229464
14MP0002084_abnormal_developmental_patter1.77745586
15MP0000427_abnormal_hair_cycle1.75488898
16MP0003763_abnormal_thymus_physiology1.73800618
17MP0001661_extended_life_span1.70595705
18MP0001697_abnormal_embryo_size1.69233111
19MP0004808_abnormal_hematopoietic_stem1.68071927
20MP0010234_abnormal_vibrissa_follicle1.64956186
21MP0002234_abnormal_pharynx_morphology1.64429227
22MP0005380_embryogenesis_phenotype1.62386367
23MP0001672_abnormal_embryogenesis/_devel1.62386367
24MP0003303_peritoneal_inflammation1.61081158
25MP0002139_abnormal_hepatobiliary_system1.60573891
26MP0001286_abnormal_eye_development1.60426120
27MP0001730_embryonic_growth_arrest1.59117564
28MP0005248_abnormal_Harderian_gland1.58702731
29MP0003436_decreased_susceptibility_to1.56665850
30MP0002697_abnormal_eye_size1.55647782
31MP0002088_abnormal_embryonic_growth/wei1.55434391
32MP0005076_abnormal_cell_differentiation1.55229685
33MP0003984_embryonic_growth_retardation1.53391703
34MP0000428_abnormal_craniofacial_morphol1.52092923
35MP0002085_abnormal_embryonic_tissue1.51528443
36MP0002877_abnormal_melanocyte_morpholog1.50513282
37MP0008877_abnormal_DNA_methylation1.49713160
38MP0002006_tumorigenesis1.49028562
39MP0001800_abnormal_humoral_immune1.48529243
40MP0003693_abnormal_embryo_hatching1.48277286
41MP0005187_abnormal_penis_morphology1.45693778
42MP0003567_abnormal_fetal_cardiomyocyte1.44163302
43MP0006054_spinal_hemorrhage1.43515385
44MP0003935_abnormal_craniofacial_develop1.42382334
45MP0000647_abnormal_sebaceous_gland1.41913264
46MP0001299_abnormal_eye_distance/1.39854837
47MP0001293_anophthalmia1.39385901
48MP0010307_abnormal_tumor_latency1.38919073
49MP0009053_abnormal_anal_canal1.38406162
50MP0009278_abnormal_bone_marrow1.38285817
51MP0000685_abnormal_immune_system1.36656835
52MP0000383_abnormal_hair_follicle1.35389779
53MP0002233_abnormal_nose_morphology1.32941735
54MP0010155_abnormal_intestine_physiology1.30287269
55MP0003183_abnormal_peptide_metabolism1.30206385
56MP0005085_abnormal_gallbladder_physiolo1.30088651
57MP0001790_abnormal_immune_system1.29776075
58MP0005387_immune_system_phenotype1.29776075
59MP0010678_abnormal_skin_adnexa1.29527331
60MP0000465_gastrointestinal_hemorrhage1.26832635
61MP0004782_abnormal_surfactant_physiolog1.26654655
62MP0000490_abnormal_crypts_of1.25833483
63MP0005365_abnormal_bile_salt1.24939795
64MP0005397_hematopoietic_system_phenotyp1.20856561
65MP0001545_abnormal_hematopoietic_system1.20856561
66MP0002751_abnormal_autonomic_nervous1.20749198
67MP0003755_abnormal_palate_morphology1.18397448
68MP0002080_prenatal_lethality1.17529898
69MP0003453_abnormal_keratinocyte_physiol1.16936196
70MP0005000_abnormal_immune_tolerance1.15824262
71MP0001835_abnormal_antigen_presentation1.14546757
72MP0001666_abnormal_nutrient_absorption1.14000067
73MP0003385_abnormal_body_wall1.12995834
74MP0001873_stomach_inflammation1.12535787
75MP0002452_abnormal_antigen_presenting1.12017685
76MP0004264_abnormal_extraembryonic_tissu1.11641558
77MP0003091_abnormal_cell_migration1.11476960
78MP0002405_respiratory_system_inflammati1.11171329
79MP0002177_abnormal_outer_ear1.11092858
80MP0002111_abnormal_tail_morphology1.10772463
81MP0002398_abnormal_bone_marrow1.10097947
82MP0000569_abnormal_digit_pigmentation1.09467322
83MP0003786_premature_aging1.09455266
84MP0000432_abnormal_head_morphology1.09308007
85MP0004947_skin_inflammation1.09164907
86MP0005671_abnormal_response_to1.08440427
87MP0003724_increased_susceptibility_to1.08062069
88MP0002092_abnormal_eye_morphology1.06724548
89MP0005220_abnormal_exocrine_pancreas1.06590082
90MP0002933_joint_inflammation1.06515451
91MP0003566_abnormal_cell_adhesion1.05909098
92MP0002060_abnormal_skin_morphology1.05495466
93MP0002138_abnormal_hepatobiliary_system1.04781872
94MP0010094_abnormal_chromosome_stability1.02894261
95MP0002723_abnormal_immune_serum1.02142956
96MP0003828_pulmonary_edema1.02053588
97MP0001853_heart_inflammation1.01771820
98MP0000537_abnormal_urethra_morphology1.01120372
99MP0009333_abnormal_splenocyte_physiolog1.01031386
100MP0003941_abnormal_skin_development1.00861055
101MP0005023_abnormal_wound_healing1.00279468
102MP0003077_abnormal_cell_cycle0.99933827
103MP0006292_abnormal_olfactory_placode0.99649381
104MP0003943_abnormal_hepatobiliary_system0.98027562
105MP0000689_abnormal_spleen_morphology0.96784449
106MP0002420_abnormal_adaptive_immunity0.96660544
107MP0000733_abnormal_muscle_development0.96475071
108MP0008057_abnormal_DNA_replication0.96248983
109MP0002102_abnormal_ear_morphology0.96031605
110MP0003861_abnormal_nervous_system0.95004072
111MP0002098_abnormal_vibrissa_morphology0.94575626
112MP0003111_abnormal_nucleus_morphology0.94444439
113MP0000377_abnormal_hair_follicle0.94253839
114MP0000703_abnormal_thymus_morphology0.94036618
115MP0002722_abnormal_immune_system0.93956176
116MP0001819_abnormal_immune_cell0.93185726
117MP0003718_maternal_effect0.91857678
118MP0005464_abnormal_platelet_physiology0.90580931
119MP0001845_abnormal_inflammatory_respons0.90566660
120MP0000716_abnormal_immune_system0.90052956
121MP0003868_abnormal_feces_composition0.88618177
122MP0000778_abnormal_nervous_system0.88497373
123MP0001533_abnormal_skeleton_physiology0.88064478
124MP0009785_altered_susceptibility_to0.86299272
125MP0008875_abnormal_xenobiotic_pharmacok0.85794198
126MP0000609_abnormal_liver_physiology0.85220791
127MP0002019_abnormal_tumor_incidence0.84843150
128MP0005174_abnormal_tail_pigmentation0.84016410
129MP0000631_abnormal_neuroendocrine_gland0.83541204
130MP0003119_abnormal_digestive_system0.82335908
131MP0003448_altered_tumor_morphology0.81331708
132MP0001915_intracranial_hemorrhage0.81144573
133MP0005025_abnormal_response_to0.80998747
134MP0000313_abnormal_cell_death0.80895830
135MP0002928_abnormal_bile_duct0.80571167
136MP0010030_abnormal_orbit_morphology0.80158044
137MP0000627_abnormal_mammary_gland0.80139171
138MP0004957_abnormal_blastocyst_morpholog0.79474449
139MP0005451_abnormal_body_composition0.79038198
140MP0002429_abnormal_blood_cell0.78358116
141MP0003937_abnormal_limbs/digits/tail_de0.78078457
142MP0002419_abnormal_innate_immunity0.77707454
143MP0000477_abnormal_intestine_morphology0.77389320
144MP0001216_abnormal_epidermal_layer0.76825036
145MP0002184_abnormal_innervation0.75878374
146MP0002086_abnormal_extraembryonic_tissu0.75401381
147MP0000613_abnormal_salivary_gland0.75223511
148MP0001346_abnormal_lacrimal_gland0.74790447
149MP0004197_abnormal_fetal_growth/weight/0.74664724
150MP0003950_abnormal_plasma_membrane0.74608351
151MP0009703_decreased_birth_body0.74321049
152MP0001191_abnormal_skin_condition0.74170454
153MP0005391_vision/eye_phenotype0.74115077
154MP0002081_perinatal_lethality0.73893279
155MP0008007_abnormal_cellular_replicative0.73609282
156MP0000350_abnormal_cell_proliferation0.73104799
157MP0009384_cardiac_valve_regurgitation0.72559635
158MP0000858_altered_metastatic_potential0.71178394
159MP0009250_abnormal_appendicular_skeleto0.69304396
160MP0002925_abnormal_cardiovascular_devel0.69278992
161MP0000762_abnormal_tongue_morphology0.68390816
162MP0002210_abnormal_sex_determination0.67992611
163MP0002109_abnormal_limb_morphology0.67209055
164MP0001177_atelectasis0.66033173
165MP0000049_abnormal_middle_ear0.63741223
166MP0001340_abnormal_eyelid_morphology0.63262898
167MP0005621_abnormal_cell_physiology0.61382235
168MP0002896_abnormal_bone_mineralization0.61335758

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.33448905
2Aplasia/Hypoplasia of the uvula (HP:0010293)3.61349321
3Abnormality of chromosome stability (HP:0003220)3.27973924
4Abnormality of the fingertips (HP:0001211)3.13965511
5Papillary thyroid carcinoma (HP:0002895)3.04787132
6Abnormal foot bone ossification (HP:0010675)2.85771783
7Transitional cell carcinoma of the bladder (HP:0006740)2.81964477
8Lip pit (HP:0100267)2.76180985
9Abnormality of the nasal septum (HP:0000419)2.71239542
10Abnormality of the preputium (HP:0100587)2.71119772
11Heterotopia (HP:0002282)2.70652470
12Bladder carcinoma (HP:0002862)2.66902886
13Bladder neoplasm (HP:0009725)2.66902886
14Meckel diverticulum (HP:0002245)2.65317892
15IgM deficiency (HP:0002850)2.64918419
16Thyroid carcinoma (HP:0002890)2.58777208
17Spontaneous hematomas (HP:0007420)2.57568292
18Nephroblastoma (Wilms tumor) (HP:0002667)2.57355660
19Syringomyelia (HP:0003396)2.55367406
20Spinal cord lesions (HP:0100561)2.55367406
21Abnormality of the ileum (HP:0001549)2.49067843
22Embryonal renal neoplasm (HP:0011794)2.48161061
23Hypoplastic ischia (HP:0003175)2.46643581
24Neoplasm of the oral cavity (HP:0100649)2.45850233
25T lymphocytopenia (HP:0005403)2.45550918
26Abnormal pancreas size (HP:0012094)2.45297788
27Neoplasm of the adrenal cortex (HP:0100641)2.44783277
28Thoracolumbar scoliosis (HP:0002944)2.37807779
29Abnormality of T cell number (HP:0011839)2.36973472
30Duodenal stenosis (HP:0100867)2.33083365
31Small intestinal stenosis (HP:0012848)2.33083365
32Abnormality of the carotid arteries (HP:0005344)2.32970570
33Leiomyosarcoma (HP:0100243)2.31635217
34Uterine leiomyosarcoma (HP:0002891)2.31635217
35Breast carcinoma (HP:0003002)2.28351524
36Hepatoblastoma (HP:0002884)2.28007908
37Rectal prolapse (HP:0002035)2.27643392
38Flat acetabular roof (HP:0003180)2.27486405
39Chronic diarrhea (HP:0002028)2.26559785
40Absent eyebrow (HP:0002223)2.25583560
41Cortical dysplasia (HP:0002539)2.23147879
42Recurrent viral infections (HP:0004429)2.22878148
43Cystic hygroma (HP:0000476)2.21443443
44Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.21422696
45Glioma (HP:0009733)2.21291874
46Deep philtrum (HP:0002002)2.20752375
47Myocardial infarction (HP:0001658)2.19312790
48Skull defect (HP:0001362)2.18517305
49Cupped ribs (HP:0000887)2.16283921
50Progressive inability to walk (HP:0002505)2.16202569
51Cubitus valgus (HP:0002967)2.16055347
52Abnormality of the duodenum (HP:0002246)2.15542153
53Arteriovenous malformation (HP:0100026)2.14829584
54Myelodysplasia (HP:0002863)2.14692695
55Osteolytic defects of the phalanges of the hand (HP:0009771)2.13644903
56Osteolytic defects of the hand bones (HP:0009699)2.13644903
57Curly hair (HP:0002212)2.11738938
58Medulloblastoma (HP:0002885)2.11416054
59Abnormality of chromosome segregation (HP:0002916)2.10670538
60Biliary tract neoplasm (HP:0100574)2.09638798
61Abnormality of the ischium (HP:0003174)2.08546061
62Autoimmune thrombocytopenia (HP:0001973)2.07819159
63High anterior hairline (HP:0009890)2.07640552
64Hematochezia (HP:0002573)2.06725012
65Abnormality of the astrocytes (HP:0100707)2.05817608
66Astrocytoma (HP:0009592)2.05817608
67Long eyelashes (HP:0000527)2.05116006
68Abnormal biliary tract morphology (HP:0012440)2.04692187
69Rhabdomyosarcoma (HP:0002859)2.02433563
70Capillary hemangiomas (HP:0005306)2.01002440
71Abnormal platelet volume (HP:0011876)2.00470175
72Aplasia cutis congenita (HP:0001057)1.99920075
73Abdominal situs inversus (HP:0003363)1.98244028
74Abnormality of abdominal situs (HP:0011620)1.98244028
75Cellulitis (HP:0100658)1.97558213
76IgA deficiency (HP:0002720)1.96004211
77Aqueductal stenosis (HP:0002410)1.95665926
78Abnormality of the common coagulation pathway (HP:0010990)1.95009664
79Abnormality of the lower motor neuron (HP:0002366)1.94936472
80Abnormality of T cells (HP:0002843)1.94756749
81Thyroiditis (HP:0100646)1.93902505
82Volvulus (HP:0002580)1.93801524
83Abnormality of the prostate (HP:0008775)1.93421397
84Clubbing of toes (HP:0100760)1.91103325
85Inflammation of the large intestine (HP:0002037)1.90007280
86Persistence of primary teeth (HP:0006335)1.89300426
87Abnormality of monocarboxylic acid metabolism (HP:0010996)1.89020053
88Hypoplastic labia majora (HP:0000059)1.88751059
89Uterine neoplasm (HP:0010784)1.88737401
90Basal cell carcinoma (HP:0002671)1.87905350
91Abnormality of the intrinsic pathway (HP:0010989)1.87681139
92Long nose (HP:0003189)1.85617424
93Colon cancer (HP:0003003)1.84506472
94Protruding tongue (HP:0010808)1.84354503
95Abnormal tarsal ossification (HP:0008369)1.83737484
96Recurrent fungal infections (HP:0002841)1.83113657
97Entropion (HP:0000621)1.83020227
98Abnormal lung lobation (HP:0002101)1.81924436
99Acute lymphatic leukemia (HP:0006721)1.80630109
100Colitis (HP:0002583)1.79730483
101Gastrointestinal inflammation (HP:0004386)1.79685920
102Limited elbow extension (HP:0001377)1.79381103
103Sandal gap (HP:0001852)1.78795805
104Increased IgE level (HP:0003212)1.78485498
105Squamous cell carcinoma (HP:0002860)1.78313874
106Cafe-au-lait spot (HP:0000957)1.78272204
107Ectopic kidney (HP:0000086)1.78098004
108Neoplasm of the small intestine (HP:0100833)1.76307207
109Abnormality of the intervertebral disk (HP:0005108)1.76187147
110Deep venous thrombosis (HP:0002625)1.76126545
111Increased nuchal translucency (HP:0010880)1.75664549
112Lymphopenia (HP:0001888)1.75493938
113Acute myeloid leukemia (HP:0004808)1.74923972
114Periodontitis (HP:0000704)1.74177595
115Asymmetry of the thorax (HP:0001555)1.74125649
116Prostate neoplasm (HP:0100787)1.74037057
117Neoplasm of the thyroid gland (HP:0100031)1.73643699
118Sloping forehead (HP:0000340)1.73028931
119Cutaneous melanoma (HP:0012056)1.72934531
120Ulnar bowing (HP:0003031)1.72855498
121Abnormality of the distal phalanges of the toes (HP:0010182)1.72266062
122Recurrent bronchitis (HP:0002837)1.71511473
123Lower limb hyperreflexia (HP:0002395)1.71459604
124Increased mean platelet volume (HP:0011877)1.71264779
125Agammaglobulinemia (HP:0004432)1.71074346
126Abnormality of cells of the lymphoid lineage (HP:0012140)1.70662026
127Abnormal hand bone ossification (HP:0010660)1.70189137
128Thin bony cortex (HP:0002753)1.68966347
129Abnormality of the labia majora (HP:0012881)1.68647820
130Abnormality of T cell physiology (HP:0011840)1.68583241
131Facial hemangioma (HP:0000329)1.68424228
132Abnormality of the septum pellucidum (HP:0007375)1.68347222
133Absent frontal sinuses (HP:0002688)1.68276613
134Renal cortical cysts (HP:0000803)1.67987563
135Insidious onset (HP:0003587)1.67975353
136Termporal pattern (HP:0011008)1.67975353
137Subacute progressive viral hepatitis (HP:0006572)1.67936113
138Overlapping toe (HP:0001845)1.67729562
139Deviation of the thumb (HP:0009603)1.67007145
140Oligodactyly (hands) (HP:0001180)1.65950537
141Eosinophilia (HP:0001880)1.65908785
142Pustule (HP:0200039)1.65456833
143Arterial thrombosis (HP:0004420)1.65322690
144Vasculitis (HP:0002633)1.64823017
145Intestinal atresia (HP:0011100)1.64609129
146Esophageal varix (HP:0002040)1.64492217
147Tibial bowing (HP:0002982)1.63259586
148Abnormality of the corticospinal tract (HP:0002492)1.62993713
149Broad palm (HP:0001169)1.62764862
150Oligodontia (HP:0000677)1.62717647
151Mesomelia (HP:0003027)1.62396529
152Severe combined immunodeficiency (HP:0004430)1.61343108
153Osteomyelitis (HP:0002754)1.60723310
154Neuroectodermal neoplasm (HP:0030061)1.60455452
155Neuroepithelial neoplasm (HP:0030063)1.60455452
156Nervous tissue neoplasm (HP:0030060)1.60455452
157Malignant gastrointestinal tract tumors (HP:0006749)1.59979050
158Gastrointestinal carcinoma (HP:0002672)1.59979050
159Reticulocytopenia (HP:0001896)1.59346117
160Ependymoma (HP:0002888)1.58451587
161Exostoses (HP:0100777)1.58366603
162Drooling (HP:0002307)1.58349109
163Abnormal delayed hypersensitivity skin test (HP:0002963)1.57412275
164Triangular face (HP:0000325)1.57151157
165Epidermoid cyst (HP:0200040)1.56947378
166Short middle phalanx of the 5th finger (HP:0004220)1.56726160
167Absent radius (HP:0003974)1.56462205
168Chronic otitis media (HP:0000389)1.55831805
169Bifid tongue (HP:0010297)1.55411887
170Proximal placement of thumb (HP:0009623)1.55394262
171Urethral obstruction (HP:0000796)1.55366918
172High pitched voice (HP:0001620)1.55284284
173Abnormality of eosinophils (HP:0001879)1.55105456
174Macroorchidism (HP:0000053)1.54861794
175Preaxial foot polydactyly (HP:0001841)1.54637808
176Narrow palate (HP:0000189)1.54197743
177Urinary urgency (HP:0000012)1.53952068
178Embryonal neoplasm (HP:0002898)1.53810265
179Poikiloderma (HP:0001029)1.53699213
180Hypopigmentation of the fundus (HP:0007894)1.53575433
181Chromsome breakage (HP:0040012)1.53482957
182Abnormality of B cell number (HP:0010975)1.52895663
183B lymphocytopenia (HP:0010976)1.52895663
184Hypochromic anemia (HP:0001931)1.52762687
185Gingival bleeding (HP:0000225)1.52751016
186Prolonged bleeding time (HP:0003010)1.52486588
187Lymphoma (HP:0002665)1.52029657
188Abnormal vertebral ossification (HP:0100569)1.51885859
189Meningitis (HP:0001287)1.51836223
190Abnormality of the antihelix (HP:0009738)1.50633180

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK33.37011787
2BCR3.00030676
3LATS12.63983619
4PKN22.53739804
5MAP3K102.30226464
6EEF2K2.25053627
7MAP4K12.21346145
8CDK122.14877677
9MAP3K142.07567661
10RPS6KA42.06608470
11FRK2.05533213
12NEK92.04218666
13NUAK12.04087094
14TAF11.97627199
15TTK1.86347878
16SCYL21.83336267
17FGFR31.81087555
18PTK61.76775651
19BLK1.73676702
20WEE11.69887042
21EIF2AK11.68593231
22CDK61.66926143
23FGFR41.66853389
24STK38L1.64544216
25STK101.62385904
26TRIM281.56584874
27PBK1.55430714
28STK31.55425135
29ERN11.54441511
30TYK21.53270467
31PNCK1.53251560
32NLK1.46614359
33CDK41.46297286
34MAP2K31.46093548
35SIK11.44917834
36TRIB31.42628721
37ITK1.42434965
38JAK11.40591564
39TSSK61.35753852
40TAOK31.32653326
41MAP3K41.30057797
42STK41.28426523
43PIM11.28230241
44ZAK1.26172752
45CAMK1D1.24960585
46CHEK21.24942423
47DMPK1.24742750
48NEK21.23323351
49LRRK21.21279253
50TXK1.19824089
51PLK31.18754058
52ERBB31.16918045
53JAK31.14032994
54BTK1.14020847
55BRD41.10830776
56PLK11.10378743
57CHUK1.10064227
58TEC1.08389905
59MAP3K31.07091526
60BUB11.05501383
61FLT31.05070782
62MELK1.04943490
63EIF2AK21.01497572
64DYRK31.00907227
65CASK1.00451400
66ACVR1B0.98882078
67EPHB10.98787041
68MST40.97702860
69IKBKE0.96988859
70TRPM70.96715258
71EPHA30.93001803
72RPS6KB20.92873302
73IRAK30.90653352
74TGFBR10.90521349
75TBK10.89697023
76CDK90.89251198
77MKNK20.87975151
78GRK60.87216325
79HIPK20.87151560
80KSR10.87122439
81CSK0.86888090
82PDGFRA0.86725076
83MTOR0.85183852
84IKBKB0.84197484
85FGFR20.82669574
86MAP2K70.82400757
87MAP3K70.78989562
88AKT30.78757752
89PRKCH0.78570096
90ZAP700.78503077
91CDC70.78105643
92MET0.76180427
93MKNK10.75685171
94AURKB0.75621290
95TTN0.73805081
96PASK0.73654377
97CAMK1G0.71880894
98PDGFRB0.70701111
99SRPK10.70099339
100ATR0.69897907
101JAK20.69880661
102MST1R0.69832714
103STK240.69589190
104IRAK40.69287312
105TGFBR20.68503258
106CCNB10.67977658
107MAP3K130.66590015
108MARK30.66253623
109CDK30.64922024
110CSNK1A1L0.64653738
111BMPR1B0.64624338
112STK390.62502954
113SGK20.61398715
114MAP3K60.60787431
115IRAK10.60374315
116CSNK1G10.59726574
117TNIK0.59023109
118HCK0.58729699
119FGFR10.58662365
120WNK10.57389130
121YES10.54896427
122MAP3K80.54237818
123BRSK20.54037509
124CDK70.53885799
125PRKAA20.53812222
126LCK0.52893713
127PAK40.52763246
128CSF1R0.52350541
129PLK20.51472844
130PRKDC0.49705622
131CSNK1G20.49509273
132NEK10.49426386
133PAK20.48727988
134SIK30.48680366
135GSK3A0.48510557
136EPHB20.47566373
137LATS20.46926711
138ATM0.46564297
139CDK10.46122037
140DYRK1B0.45985518
141ABL10.45881055
142CDC42BPA0.45615231
143CHEK10.45599969
144RPS6KA50.44503308
145ALK0.44025946
146ERBB40.43992443
147PLK40.43849378
148KIT0.43411424
149TLK10.43353236
150NEK60.41029147
151PRKD20.40850575
152RPS6KB10.40822668
153PRKCE0.40021577
154CSNK1E0.39820354
155SGK30.39611858
156CDK20.38398251

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.13687002
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.90324081
3Basal transcription factors_Homo sapiens_hsa030222.72974356
4RNA transport_Homo sapiens_hsa030132.55797629
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.36757787
6Mismatch repair_Homo sapiens_hsa034302.36501155
7Protein export_Homo sapiens_hsa030602.22808943
8Homologous recombination_Homo sapiens_hsa034402.16417496
9Spliceosome_Homo sapiens_hsa030402.07556355
10Nucleotide excision repair_Homo sapiens_hsa034202.05360034
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.00395047
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.86423954
13RNA degradation_Homo sapiens_hsa030181.75304447
14Small cell lung cancer_Homo sapiens_hsa052221.72249452
15Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.71201486
16Primary immunodeficiency_Homo sapiens_hsa053401.70879106
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.62689705
18Selenocompound metabolism_Homo sapiens_hsa004501.59009821
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.56592126
20Lysine degradation_Homo sapiens_hsa003101.52400850
21B cell receptor signaling pathway_Homo sapiens_hsa046621.51973293
22Caffeine metabolism_Homo sapiens_hsa002321.51213781
23Base excision repair_Homo sapiens_hsa034101.48187032
24Chronic myeloid leukemia_Homo sapiens_hsa052201.47827973
25Measles_Homo sapiens_hsa051621.37584263
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.33493081
27Herpes simplex infection_Homo sapiens_hsa051681.29865829
28Staphylococcus aureus infection_Homo sapiens_hsa051501.28476273
29Toxoplasmosis_Homo sapiens_hsa051451.28323613
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.28126978
31MicroRNAs in cancer_Homo sapiens_hsa052061.26628163
32Leishmaniasis_Homo sapiens_hsa051401.26372549
33p53 signaling pathway_Homo sapiens_hsa041151.25912700
34Transcriptional misregulation in cancer_Homo sapiens_hsa052021.24441427
35Acute myeloid leukemia_Homo sapiens_hsa052211.24002683
36Pancreatic cancer_Homo sapiens_hsa052121.22596552
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.22472516
38Renal cell carcinoma_Homo sapiens_hsa052111.17454261
39T cell receptor signaling pathway_Homo sapiens_hsa046601.15328282
40Osteoclast differentiation_Homo sapiens_hsa043801.12895654
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.10896625
42Hematopoietic cell lineage_Homo sapiens_hsa046401.10650034
43* Jak-STAT signaling pathway_Homo sapiens_hsa046301.10091120
44ErbB signaling pathway_Homo sapiens_hsa040121.09086180
45Cell cycle_Homo sapiens_hsa041101.08549358
46Prostate cancer_Homo sapiens_hsa052151.06504997
47Non-homologous end-joining_Homo sapiens_hsa034501.05158585
48Systemic lupus erythematosus_Homo sapiens_hsa053221.04128513
49Apoptosis_Homo sapiens_hsa042101.04088369
50RNA polymerase_Homo sapiens_hsa030201.03147711
51Primary bile acid biosynthesis_Homo sapiens_hsa001201.02414420
52Hippo signaling pathway_Homo sapiens_hsa043901.02413836
53Hepatitis B_Homo sapiens_hsa051611.02342862
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.99407345
55Antigen processing and presentation_Homo sapiens_hsa046120.98623603
56Viral carcinogenesis_Homo sapiens_hsa052030.98452421
57Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.97012251
58Oocyte meiosis_Homo sapiens_hsa041140.96828004
59Complement and coagulation cascades_Homo sapiens_hsa046100.96496292
60Insulin resistance_Homo sapiens_hsa049310.95518294
61ABC transporters_Homo sapiens_hsa020100.95146444
62Tryptophan metabolism_Homo sapiens_hsa003800.95084605
63One carbon pool by folate_Homo sapiens_hsa006700.95045585
64TNF signaling pathway_Homo sapiens_hsa046680.94691731
65mTOR signaling pathway_Homo sapiens_hsa041500.94515112
66Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94340629
67Nitrogen metabolism_Homo sapiens_hsa009100.93227994
68Melanoma_Homo sapiens_hsa052180.92663461
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.92209147
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.92053124
71Chemical carcinogenesis_Homo sapiens_hsa052040.91627204
72Starch and sucrose metabolism_Homo sapiens_hsa005000.90865475
73HTLV-I infection_Homo sapiens_hsa051660.87354063
74Alcoholism_Homo sapiens_hsa050340.86547144
75Endometrial cancer_Homo sapiens_hsa052130.85786855
76Renin-angiotensin system_Homo sapiens_hsa046140.85080236
77Hepatitis C_Homo sapiens_hsa051600.84626035
78Glioma_Homo sapiens_hsa052140.83998155
79Retinol metabolism_Homo sapiens_hsa008300.83860140
80Legionellosis_Homo sapiens_hsa051340.82211859
81Adherens junction_Homo sapiens_hsa045200.81360780
82Vitamin digestion and absorption_Homo sapiens_hsa049770.81226250
83FoxO signaling pathway_Homo sapiens_hsa040680.80837485
84Malaria_Homo sapiens_hsa051440.79976583
85Fatty acid degradation_Homo sapiens_hsa000710.79512584
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79244325
87Pyrimidine metabolism_Homo sapiens_hsa002400.78083608
88Fat digestion and absorption_Homo sapiens_hsa049750.76103658
89Viral myocarditis_Homo sapiens_hsa054160.75834887
90ECM-receptor interaction_Homo sapiens_hsa045120.75682117
91Shigellosis_Homo sapiens_hsa051310.75643356
92Proteoglycans in cancer_Homo sapiens_hsa052050.75068249
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73573837
94Sulfur metabolism_Homo sapiens_hsa009200.72317608
95Influenza A_Homo sapiens_hsa051640.72292568
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70842633
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70673359
98Wnt signaling pathway_Homo sapiens_hsa043100.69952414
99Focal adhesion_Homo sapiens_hsa045100.66358274
100Non-small cell lung cancer_Homo sapiens_hsa052230.65838851
101Hedgehog signaling pathway_Homo sapiens_hsa043400.65105736
102mRNA surveillance pathway_Homo sapiens_hsa030150.64604436
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64418348
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63843428
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62615759
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.62255401
107* Prolactin signaling pathway_Homo sapiens_hsa049170.62072201
108PPAR signaling pathway_Homo sapiens_hsa033200.61401303
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61186786
110Autoimmune thyroid disease_Homo sapiens_hsa053200.60730271
111Thyroid cancer_Homo sapiens_hsa052160.60287106
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59658858
113TGF-beta signaling pathway_Homo sapiens_hsa043500.59272704
114Basal cell carcinoma_Homo sapiens_hsa052170.59157400
115Bladder cancer_Homo sapiens_hsa052190.58968814
116Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58239430
117DNA replication_Homo sapiens_hsa030300.57979138
118Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57935703
119Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57808791
120Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57485134
121Purine metabolism_Homo sapiens_hsa002300.57021746
122Fanconi anemia pathway_Homo sapiens_hsa034600.56805538
123Fatty acid biosynthesis_Homo sapiens_hsa000610.56275839
124Platelet activation_Homo sapiens_hsa046110.54977748
125Protein digestion and absorption_Homo sapiens_hsa049740.54808873
126Epstein-Barr virus infection_Homo sapiens_hsa051690.54567395
127Inositol phosphate metabolism_Homo sapiens_hsa005620.53838469
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.53321177
129Colorectal cancer_Homo sapiens_hsa052100.52031465
130Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52020555
131Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49607521
132Pathways in cancer_Homo sapiens_hsa052000.49398540
133Dorso-ventral axis formation_Homo sapiens_hsa043200.49307609
134Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48998337
135PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48688450
136Pertussis_Homo sapiens_hsa051330.48631281
137Circadian rhythm_Homo sapiens_hsa047100.45509514
138Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44488589
139Axon guidance_Homo sapiens_hsa043600.41926418
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.41894204
141Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41545810
142N-Glycan biosynthesis_Homo sapiens_hsa005100.39927977
143Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39364284
144Central carbon metabolism in cancer_Homo sapiens_hsa052300.38375377
145Tight junction_Homo sapiens_hsa045300.38127730
146* Type II diabetes mellitus_Homo sapiens_hsa049300.37823614
147Taste transduction_Homo sapiens_hsa047420.36203070
148Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35173541
149Cysteine and methionine metabolism_Homo sapiens_hsa002700.34180690
150Choline metabolism in cancer_Homo sapiens_hsa052310.32560520
151Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32117309
152Rap1 signaling pathway_Homo sapiens_hsa040150.31580936
153Regulation of autophagy_Homo sapiens_hsa041400.28564423
154Ras signaling pathway_Homo sapiens_hsa040140.27848892

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