SOCS5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.35537882
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.32048263
3locomotory exploration behavior (GO:0035641)5.22248747
4collagen fibril organization (GO:0030199)5.21067958
5synaptic vesicle exocytosis (GO:0016079)5.04389169
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.02453740
7vocalization behavior (GO:0071625)4.88913492
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.88101325
9glutamate secretion (GO:0014047)4.70079956
10synaptic vesicle docking involved in exocytosis (GO:0016081)4.51281912
11regulation of synaptic vesicle exocytosis (GO:2000300)4.50214007
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.47214631
13skin morphogenesis (GO:0043589)4.40213180
14sequestering of extracellular ligand from receptor (GO:0035581)4.38145047
15chondrocyte proliferation (GO:0035988)4.31550329
16cell migration involved in heart development (GO:0060973)4.29849422
17regulation of glutamate receptor signaling pathway (GO:1900449)4.28729661
18kidney mesenchyme development (GO:0072074)4.25301408
19neuronal action potential propagation (GO:0019227)4.21640761
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.11261301
21neurotransmitter secretion (GO:0007269)4.10132617
22regulation of synapse structural plasticity (GO:0051823)4.06588994
23protein localization to synapse (GO:0035418)4.02584815
24mesenchymal-epithelial cell signaling (GO:0060638)4.00340676
25protein heterotrimerization (GO:0070208)3.99980172
26regulation of synaptic vesicle transport (GO:1902803)3.96970868
27endocardial cushion development (GO:0003197)3.96938739
28regulation of neuronal synaptic plasticity (GO:0048168)3.96527533
29cell adhesion mediated by integrin (GO:0033627)3.96401179
30exploration behavior (GO:0035640)3.96365490
31layer formation in cerebral cortex (GO:0021819)3.93328440
32metanephric mesenchyme development (GO:0072075)3.92958278
33type B pancreatic cell proliferation (GO:0044342)3.87428011
34ionotropic glutamate receptor signaling pathway (GO:0035235)3.85067839
35neuron cell-cell adhesion (GO:0007158)3.80890070
36endodermal cell differentiation (GO:0035987)3.69524683
37bone trabecula formation (GO:0060346)3.69336582
38dendritic spine morphogenesis (GO:0060997)3.60434535
39regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.55845256
40extracellular matrix assembly (GO:0085029)3.55449728
41membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.51943473
42chondrocyte development (GO:0002063)3.51189818
43neuron-neuron synaptic transmission (GO:0007270)3.50440191
44activation of protein kinase A activity (GO:0034199)3.49503637
45gamma-aminobutyric acid transport (GO:0015812)3.48996556
46synaptic transmission, glutamatergic (GO:0035249)3.47144858
47anterior/posterior axis specification, embryo (GO:0008595)3.47044329
48glutamate receptor signaling pathway (GO:0007215)3.46018436
49regulation of excitatory postsynaptic membrane potential (GO:0060079)3.44915399
50smooth muscle tissue development (GO:0048745)3.44380570
51negative regulation of synaptic transmission, GABAergic (GO:0032229)3.42915864
52regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.41700492
53regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.41090785
54regulation of dendritic spine morphogenesis (GO:0061001)3.37447635
55positive regulation of membrane potential (GO:0045838)3.35504894
56long-term memory (GO:0007616)3.32348002
57neuron recognition (GO:0008038)3.29554158
58pericardium development (GO:0060039)3.27001492
59regulation of synaptic plasticity (GO:0048167)3.26871298
60regulation of postsynaptic membrane potential (GO:0060078)3.26457404
61substrate-dependent cell migration (GO:0006929)3.24442564
62cellular potassium ion homeostasis (GO:0030007)3.23477250
63neurotransmitter transport (GO:0006836)3.22843076
64proline transport (GO:0015824)3.22510448
65neurotransmitter-gated ion channel clustering (GO:0072578)3.22449112
66dermatan sulfate biosynthetic process (GO:0030208)3.21686149
67negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.21375143
68cell migration involved in sprouting angiogenesis (GO:0002042)3.19901887
69gamma-aminobutyric acid signaling pathway (GO:0007214)3.18960947
70hypotonic response (GO:0006971)3.16303878
71neuromuscular process controlling balance (GO:0050885)3.16154735
72long-term synaptic potentiation (GO:0060291)3.15246362
73transmission of nerve impulse (GO:0019226)3.13908973
74regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.13828069
75axonal fasciculation (GO:0007413)3.11650513
76regulation of vesicle fusion (GO:0031338)3.08710393
77blood vessel maturation (GO:0001955)3.07823966
78positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.06921279
79collagen metabolic process (GO:0032963)3.05176695
80sodium ion export (GO:0071436)3.04874742
81cellular response to vitamin (GO:0071295)3.03972802
82regulation of synaptic transmission, glutamatergic (GO:0051966)3.03217117
83prepulse inhibition (GO:0060134)3.02081279
84regulation of neurotransmitter levels (GO:0001505)3.01643980
85mating behavior (GO:0007617)3.01549033
86positive regulation of fibroblast migration (GO:0010763)3.00614346
87positive regulation of blood vessel endothelial cell migration (GO:0043536)2.98864238
88dermatan sulfate metabolic process (GO:0030205)2.98135885
89positive regulation of synapse maturation (GO:0090129)2.97477940
90vesicle transport along microtubule (GO:0047496)2.96339582
91negative regulation of BMP signaling pathway (GO:0030514)2.96031643
92heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.95592332
93negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.95537704
94synaptic vesicle endocytosis (GO:0048488)2.95024354
95regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.94696012
96regulation of neurotransmitter secretion (GO:0046928)2.94584629
97negative regulation of fatty acid transport (GO:2000192)2.94423938
98dendrite morphogenesis (GO:0048813)2.94338536
99endothelial cell morphogenesis (GO:0001886)2.93921816
100regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.93742093
101G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.93000777
102neuronal ion channel clustering (GO:0045161)2.91364549
103negative regulation of axon extension involved in axon guidance (GO:0048843)2.90410039
104positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.90108660
105cerebellar Purkinje cell differentiation (GO:0021702)2.89266107
106positive regulation of endothelial cell apoptotic process (GO:2000353)2.88846722
107neuromuscular process controlling posture (GO:0050884)2.88608862
108positive regulation of synaptic transmission, GABAergic (GO:0032230)2.87949673
109paraxial mesoderm development (GO:0048339)2.87691162
110cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.87108603
111dendritic spine organization (GO:0097061)2.85302256
112positive regulation of neurotransmitter transport (GO:0051590)2.84487093
113protein localization to cell surface (GO:0034394)2.84211602
114positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.83678180
115membrane depolarization (GO:0051899)2.83610935
116regulation of synaptic transmission, GABAergic (GO:0032228)2.83582998
117regulation of dendritic spine development (GO:0060998)2.83096581
118positive regulation of vesicle fusion (GO:0031340)2.82536531
119cell-substrate junction assembly (GO:0007044)2.82224583
120cellular response to vitamin D (GO:0071305)2.80916771
121regulation of neurotransmitter transport (GO:0051588)2.80466113
122multicellular organismal macromolecule metabolic process (GO:0044259)2.79728180
123collagen catabolic process (GO:0030574)2.79292287
124behavioral response to cocaine (GO:0048148)2.78811290
125extracellular negative regulation of signal transduction (GO:1900116)2.78464027
126extracellular regulation of signal transduction (GO:1900115)2.78464027
127detection of calcium ion (GO:0005513)2.77856931
128auditory behavior (GO:0031223)2.77445143
129membrane depolarization during action potential (GO:0086010)2.76929357
130response to histamine (GO:0034776)2.76852706
131COPII vesicle coating (GO:0048208)2.76802266
132regulation of voltage-gated calcium channel activity (GO:1901385)2.76427526
133vascular endothelial growth factor signaling pathway (GO:0038084)2.75668913
134cerebellar Purkinje cell layer development (GO:0021680)2.75122726
135cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.74613269
136membrane hyperpolarization (GO:0060081)2.74544537
137learning (GO:0007612)2.73194046
138postsynaptic membrane organization (GO:0001941)2.72667286
139negative regulation of cardiac muscle tissue development (GO:0055026)2.71747450
140positive regulation of synaptic transmission (GO:0050806)2.69938275
141glomerular basement membrane development (GO:0032836)2.69877703
142synapse organization (GO:0050808)2.69858132
143regulation of synaptic transmission (GO:0050804)2.68624676
144long term synaptic depression (GO:0060292)2.68542587
145wound healing, spreading of epidermal cells (GO:0035313)2.68071804
146cell communication by electrical coupling (GO:0010644)2.66957691
147neuromuscular process (GO:0050905)2.66128243
148multicellular organismal metabolic process (GO:0044236)2.65260097
149synapse assembly (GO:0007416)2.65134990
150synaptic transmission (GO:0007268)2.65078177
151protein localization to endosome (GO:0036010)2.64773535
152organelle transport along microtubule (GO:0072384)2.64752361
153positive regulation of neurotransmitter secretion (GO:0001956)2.63563119
154negative regulation of chondrocyte differentiation (GO:0032331)2.63025011
155embryonic cranial skeleton morphogenesis (GO:0048701)2.62889339
156retina vasculature morphogenesis in camera-type eye (GO:0061299)2.62162969
157regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.61732599
158regulation of fibroblast migration (GO:0010762)2.58457952
159endocytic recycling (GO:0032456)2.57210066
160stress fiber assembly (GO:0043149)2.56671951
161lymphangiogenesis (GO:0001946)2.54700007
162basement membrane organization (GO:0071711)2.53421371
163face morphogenesis (GO:0060325)2.53263945
164negative regulation of osteoblast proliferation (GO:0033689)2.51590259
165negative regulation of smooth muscle cell migration (GO:0014912)2.51169953
166adherens junction assembly (GO:0034333)2.50756573
167embryonic forelimb morphogenesis (GO:0035115)2.50588307
168substrate adhesion-dependent cell spreading (GO:0034446)2.50118011
169multicellular organismal catabolic process (GO:0044243)2.48311337
170focal adhesion assembly (GO:0048041)2.47385289
171cell-substrate adherens junction assembly (GO:0007045)2.47385289
172protein retention in ER lumen (GO:0006621)2.47159825
173regulation of type B pancreatic cell apoptotic process (GO:2000674)2.45913892
174embryonic process involved in female pregnancy (GO:0060136)2.45493061
175peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.45428748
176sprouting angiogenesis (GO:0002040)2.44627283
177extracellular matrix disassembly (GO:0022617)2.44556856
178negative regulation of stem cell proliferation (GO:2000647)2.44549675
179heparin biosynthetic process (GO:0030210)2.44240967
180heparin metabolic process (GO:0030202)2.44240967
181regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.43646119
182negative regulation of embryonic development (GO:0045992)2.43423538
183regulation of axon extension involved in axon guidance (GO:0048841)2.41643610
184regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.41618803
185cellular response to amino acid stimulus (GO:0071230)2.41330704
186platelet-derived growth factor receptor signaling pathway (GO:0048008)2.41182829
187positive regulation of protein autophosphorylation (GO:0031954)2.40662610
188hemidesmosome assembly (GO:0031581)2.39362128
189extracellular fibril organization (GO:0043206)2.38129416
190maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.37914207
191artery morphogenesis (GO:0048844)2.35999981
192barbed-end actin filament capping (GO:0051016)2.34910099
193positive regulation of osteoblast proliferation (GO:0033690)2.34801716
194endocrine hormone secretion (GO:0060986)2.33508002
195venous blood vessel morphogenesis (GO:0048845)2.33423273
196protein hydroxylation (GO:0018126)2.32662210
197positive regulation of mesenchymal cell proliferation (GO:0002053)2.31906270
198regulation of transforming growth factor beta1 production (GO:0032908)2.31844599
199regulation of organ formation (GO:0003156)2.31147841

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.33446889
2GBX2_23144817_ChIP-Seq_PC3_Human3.17744029
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.09959296
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.03533178
5WT1_19549856_ChIP-ChIP_CCG9911_Human3.01616708
6BRD4_25478319_ChIP-Seq_HGPS_Human2.97525319
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.90016692
8PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.81693683
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.74305263
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.74305263
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.70899142
12* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.70337312
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.61899120
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.56018518
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54970073
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.54925244
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.49940968
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47193724
19DROSHA_22980978_ChIP-Seq_HELA_Human2.43522014
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.41342211
21* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.34565132
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.31419906
23CJUN_26792858_Chip-Seq_BT549_Human2.29194019
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.18461461
25REST_21632747_ChIP-Seq_MESCs_Mouse2.16640044
26* EED_16625203_ChIP-ChIP_MESCs_Mouse2.16398349
27SUZ12_27294783_Chip-Seq_ESCs_Mouse2.11690257
28EZH2_27294783_Chip-Seq_ESCs_Mouse2.10029517
29CLOCK_20551151_ChIP-Seq_293T_Human2.08184079
30RNF2_27304074_Chip-Seq_ESCs_Mouse2.08040403
31RBPJ_22232070_ChIP-Seq_NCS_Mouse2.04746482
32HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.91185703
33RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.89178614
34* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.88111300
35AR_21572438_ChIP-Seq_LNCaP_Human1.82704803
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.82630232
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.82206292
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.78918145
39REST_18959480_ChIP-ChIP_MESCs_Mouse1.78428979
40SALL4_18804426_ChIP-ChIP_XEN_Mouse1.77609224
41TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.77240770
42SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.75136050
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.74352307
44* IKZF1_21737484_ChIP-ChIP_HCT116_Human1.72818785
45SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.71849175
46EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65651576
47CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.65436045
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.63742371
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57098411
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.56558412
51* SMAD4_21799915_ChIP-Seq_A2780_Human1.51966427
52SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.51791834
53SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.51791834
54WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.51293783
55TAF15_26573619_Chip-Seq_HEK293_Human1.49397939
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.46911979
57Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.45675653
58NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.45417944
59GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45106977
60ERG_21242973_ChIP-ChIP_JURKAT_Human1.44970832
61GATA2_21666600_ChIP-Seq_HMVEC_Human1.43976372
62EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.42679312
63PPAR_26484153_Chip-Seq_NCI-H1993_Human1.41911691
64CTNNB1_20460455_ChIP-Seq_HCT116_Human1.40487335
65SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39086315
66NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38206333
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36612491
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36518354
69ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36277628
70STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.35972323
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35351946
72PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33545273
73SOX9_24532713_ChIP-Seq_HFSC_Mouse1.33326166
74SOX2_21211035_ChIP-Seq_LN229_Gbm1.33253569
75EGR1_19374776_ChIP-ChIP_THP-1_Human1.32313635
76WT1_25993318_ChIP-Seq_PODOCYTE_Human1.32177333
77ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.31375432
78RING1B_27294783_Chip-Seq_ESCs_Mouse1.27483139
79SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.27161890
80ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27128731
81TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26726286
82NFIB_24661679_ChIP-Seq_LUNG_Mouse1.26073960
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25550138
84ZNF274_21170338_ChIP-Seq_K562_Hela1.25134078
85MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.24876645
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24399776
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22805309
88TP53_16413492_ChIP-PET_HCT116_Human1.22454192
89RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21180897
90P300_19829295_ChIP-Seq_ESCs_Human1.20267675
91TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19936832
92AR_19668381_ChIP-Seq_PC3_Human1.19480087
93PIAS1_25552417_ChIP-Seq_VCAP_Human1.19213758
94EP300_21415370_ChIP-Seq_HL-1_Mouse1.19129069
95SMAD3_21741376_ChIP-Seq_EPCs_Human1.16768261
96PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.15831334
97* STAT3_23295773_ChIP-Seq_U87_Human1.15751868
98AR_25329375_ChIP-Seq_VCAP_Human1.14204930
99DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13993926
100KDM2B_26808549_Chip-Seq_K562_Human1.13697938
101TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12119133
102AHR_22903824_ChIP-Seq_MCF-7_Human1.12043332
103TP63_17297297_ChIP-ChIP_HaCaT_Human1.11622827
104JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11270718
105TP53_18474530_ChIP-ChIP_U2OS_Human1.10921110
106ARNT_22903824_ChIP-Seq_MCF-7_Human1.09842076
107JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09655825
108FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09549378
109P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08892599
110* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08300332
111TRIM28_21343339_ChIP-Seq_HEK293_Human1.07889575
112* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07850212
113UBF1/2_26484160_Chip-Seq_HMECs_Human1.06779431
114HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06434131
115TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.05760432
116CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05737288
117TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05303693
118RING1B_27294783_Chip-Seq_NPCs_Mouse1.04595870
119ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04455515
120TBX20_22080862_ChIP-Seq_HEART_Mouse1.04062859
121TBX20_22328084_ChIP-Seq_HEART_Mouse1.04062859
122VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04058334
123POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03302711
124AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02539972
125RXR_22108803_ChIP-Seq_LS180_Human1.01823794
126YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00948057
127ISL1_27105846_Chip-Seq_CPCs_Mouse0.99709426
128NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98709789
129TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98131839
130TCF4_23295773_ChIP-Seq_U87_Human0.98026892
131TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98010269
132TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96721498
133RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96668271
134MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96472581
135FOXO3_23340844_ChIP-Seq_DLD1_Human0.95110473
136KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95041746
137P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94368498
138SMAD3_21741376_ChIP-Seq_ESCs_Human0.94137378
139SMC1_22415368_ChIP-Seq_MEFs_Mouse0.94104382
140SA1_22415368_ChIP-Seq_MEFs_Mouse0.93705916
141NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.92803143
142RUNX2_22187159_ChIP-Seq_PCA_Human0.92649837
143SMAD4_21741376_ChIP-Seq_HESCs_Human0.92532368
144* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92205277
145* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92205277
146PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.92138441
147SMAD3_21741376_ChIP-Seq_HESCs_Human0.90413476
148FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.90357821
149TP63_23658742_ChIP-Seq_EP156T_Human0.90198100
150FUS_26573619_Chip-Seq_HEK293_Human0.89345769
151CBX2_27304074_Chip-Seq_ESCs_Mouse0.88272676
152PRDM14_20953172_ChIP-Seq_ESCs_Human0.88267103
153BCAT_22108803_ChIP-Seq_LS180_Human0.88040015
154* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87820777
155GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87516076
156DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.87274013
157JUN_21703547_ChIP-Seq_K562_Human0.86922841
158TET1_21490601_ChIP-Seq_MESCs_Mouse0.86634844
159IGF1R_20145208_ChIP-Seq_DFB_Human0.86316238
160GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86152933

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.30899871
2MP0003880_abnormal_central_pattern4.26211373
3MP0003635_abnormal_synaptic_transmissio3.99541868
4MP0004272_abnormal_basement_membrane3.95719079
5MP0004270_analgesia3.37444542
6MP0009745_abnormal_behavioral_response3.17171008
7MP0002063_abnormal_learning/memory/cond3.04970946
8MP0002064_seizures3.04895853
9MP0009046_muscle_twitch2.99095924
10MP0002822_catalepsy2.74476382
11MP0009384_cardiac_valve_regurgitation2.68522117
12MP0005257_abnormal_intraocular_pressure2.55672208
13MP0001968_abnormal_touch/_nociception2.55014131
14MP0002572_abnormal_emotion/affect_behav2.52597317
15MP0006054_spinal_hemorrhage2.51049062
16MP0010368_abnormal_lymphatic_system2.49688485
17MP0002272_abnormal_nervous_system2.47491569
18MP0001542_abnormal_bone_strength2.41138805
19MP0010352_gastrointestinal_tract_polyps2.34060695
20MP0002734_abnormal_mechanical_nocicepti2.27440304
21MP0001486_abnormal_startle_reflex2.25308688
22MP0005423_abnormal_somatic_nervous2.24129525
23MP0003566_abnormal_cell_adhesion2.21000383
24MP0001501_abnormal_sleep_pattern2.17529256
25MP0003950_abnormal_plasma_membrane2.12519746
26MP0009780_abnormal_chondrocyte_physiolo2.08251451
27MP0002909_abnormal_adrenal_gland2.05203599
28MP0000013_abnormal_adipose_tissue2.00841367
29MP0005623_abnormal_meninges_morphology1.97183492
30MP0003941_abnormal_skin_development1.95866171
31MP0005508_abnormal_skeleton_morphology1.90712020
32MP0008569_lethality_at_weaning1.88693024
33MP0002736_abnormal_nociception_after1.87636647
34MP0002060_abnormal_skin_morphology1.87313868
35MP0003329_amyloid_beta_deposits1.82126586
36MP0001440_abnormal_grooming_behavior1.81116085
37MP0009250_abnormal_appendicular_skeleto1.78454964
38MP0002733_abnormal_thermal_nociception1.78376168
39MP0000767_abnormal_smooth_muscle1.77287224
40MP0005023_abnormal_wound_healing1.76134021
41MP0002108_abnormal_muscle_morphology1.73238305
42MP0001970_abnormal_pain_threshold1.70121463
43MP0002067_abnormal_sensory_capabilities1.69318789
44MP0002735_abnormal_chemical_nociception1.68671156
45MP0004811_abnormal_neuron_physiology1.66939685
46MP0004858_abnormal_nervous_system1.63505867
47MP0002184_abnormal_innervation1.62774435
48MP0000751_myopathy1.58128290
49MP0002896_abnormal_bone_mineralization1.56804253
50MP0002877_abnormal_melanocyte_morpholog1.55162585
51MP0005386_behavior/neurological_phenoty1.53204971
52MP0004924_abnormal_behavior1.53204971
53MP0002557_abnormal_social/conspecific_i1.48944851
54MP0001879_abnormal_lymphatic_vessel1.43861621
55MP0000733_abnormal_muscle_development1.42458216
56MP0001243_abnormal_dermal_layer1.41911302
57MP0003122_maternal_imprinting1.38963377
58MP0000778_abnormal_nervous_system1.37983593
59MP0004134_abnormal_chest_morphology1.36554883
60MP0008438_abnormal_cutaneous_collagen1.35287686
61MP0000955_abnormal_spinal_cord1.34982829
62MP0002066_abnormal_motor_capabilities/c1.30497468
63MP0003385_abnormal_body_wall1.28970655
64MP0003879_abnormal_hair_cell1.28283705
65MP0002882_abnormal_neuron_morphology1.27578948
66MP0004885_abnormal_endolymph1.27507813
67MP0006276_abnormal_autonomic_nervous1.26029739
68MP0005595_abnormal_vascular_smooth1.23669528
69MP0000428_abnormal_craniofacial_morphol1.22448426
70MP0003942_abnormal_urinary_system1.20429329
71MP0003633_abnormal_nervous_system1.20093636
72MP0001188_hyperpigmentation1.18327101
73MP0001299_abnormal_eye_distance/1.16319806
74MP0001984_abnormal_olfaction1.15327997
75MP0003283_abnormal_digestive_organ1.14212850
76MP0001177_atelectasis1.14066079
77MP0005646_abnormal_pituitary_gland1.13645360
78MP0002837_dystrophic_cardiac_calcinosis1.12880100
79MP0001905_abnormal_dopamine_level1.10585188
80MP0004145_abnormal_muscle_electrophysio1.08173185
81MP0004142_abnormal_muscle_tone1.07512124
82MP0001502_abnormal_circadian_rhythm1.04242614
83MP0000462_abnormal_digestive_system1.04055411
84MP0010234_abnormal_vibrissa_follicle1.02454023
85MP0000759_abnormal_skeletal_muscle1.00889131
86MP0003787_abnormal_imprinting0.99643671
87MP0003631_nervous_system_phenotype0.99399932
88MP0001529_abnormal_vocalization0.97416592
89MP0008874_decreased_physiological_sensi0.97049054
90MP0005503_abnormal_tendon_morphology0.96370287
91MP0000920_abnormal_myelination0.95947918
92MP0001661_extended_life_span0.94930653
93MP0004085_abnormal_heartbeat0.94846359
94MP0004084_abnormal_cardiac_muscle0.94749529
95MP0002152_abnormal_brain_morphology0.94564741
96MP0002115_abnormal_skeleton_extremities0.93973554
97MP0009053_abnormal_anal_canal0.93960867
98MP0003634_abnormal_glial_cell0.93691583
99MP0004233_abnormal_muscle_weight0.93539093
100MP0000163_abnormal_cartilage_morphology0.92897004
101MP0005645_abnormal_hypothalamus_physiol0.92818573
102MP0003937_abnormal_limbs/digits/tail_de0.92772354
103MP0002128_abnormal_blood_circulation0.91214681
104MP0000762_abnormal_tongue_morphology0.90061110
105MP0010386_abnormal_urinary_bladder0.86967075
106MP0003075_altered_response_to0.86573193
107MP0005390_skeleton_phenotype0.86392821
108MP0005275_abnormal_skin_tensile0.84917318
109MP0001958_emphysema0.84698561
110MP0008961_abnormal_basal_metabolism0.82328471
111MP0002114_abnormal_axial_skeleton0.82252883
112MP0004484_altered_response_of0.81551370
113MP0000569_abnormal_digit_pigmentation0.81537934
114MP0002113_abnormal_skeleton_development0.81068291
115MP0000747_muscle_weakness0.80363345
116MP0003045_fibrosis0.80345311
117MP0000749_muscle_degeneration0.80238529
118MP0002069_abnormal_eating/drinking_beha0.79656349
119MP0004215_abnormal_myocardial_fiber0.78970204
120MP0003828_pulmonary_edema0.78900031
121MP0002229_neurodegeneration0.78319239
122MP0010030_abnormal_orbit_morphology0.77993288
123MP0001915_intracranial_hemorrhage0.77664512
124MP0000432_abnormal_head_morphology0.76748869
125MP0003632_abnormal_nervous_system0.75951711
126MP0002090_abnormal_vision0.75802684
127MP0000003_abnormal_adipose_tissue0.75271967
128MP0005171_absent_coat_pigmentation0.74206092
129MP0003935_abnormal_craniofacial_develop0.73644857
130MP0004087_abnormal_muscle_fiber0.73258322
131MP0003115_abnormal_respiratory_system0.72636214
132MP0003690_abnormal_glial_cell0.72620599
133MP0005551_abnormal_eye_electrophysiolog0.72396458
134MP0005409_darkened_coat_color0.72142437
135MP0005164_abnormal_response_to0.70989413
136MP0001849_ear_inflammation0.70739209
137MP0001614_abnormal_blood_vessel0.70731585
138MP0002168_other_aberrant_phenotype0.70634652
139MP0004742_abnormal_vestibular_system0.70134578
140MP0005620_abnormal_muscle_contractility0.70061530
141MP0004808_abnormal_hematopoietic_stem0.69886014
142MP0003091_abnormal_cell_migration0.69501912
143MP0002133_abnormal_respiratory_system0.68639706
144MP0005388_respiratory_system_phenotype0.68639706
145MP0002925_abnormal_cardiovascular_devel0.68292867
146MP0000604_amyloidosis0.67238038
147MP0000750_abnormal_muscle_regeneration0.67111962
148MP0005197_abnormal_uvea_morphology0.66887578
149MP0008775_abnormal_heart_ventricle0.66514740
150MP0001348_abnormal_lacrimal_gland0.65014566
151MP0001175_abnormal_lung_morphology0.64604508
152MP0005535_abnormal_body_temperature0.64250761
153MP0003279_aneurysm0.64240259
154MP0002971_abnormal_brown_adipose0.64007586
155MP0003137_abnormal_impulse_conducting0.63758268
156MP0003755_abnormal_palate_morphology0.63440319
157MP0004036_abnormal_muscle_relaxation0.62996996
158MP0005369_muscle_phenotype0.62867713
159MP0005187_abnormal_penis_morphology0.62701689
160MP0001943_abnormal_respiration0.62072985
161MP0002160_abnormal_reproductive_system0.62067569
162MP0005076_abnormal_cell_differentiation0.61631223
163MP0002932_abnormal_joint_morphology0.61514241
164MP0002089_abnormal_postnatal_growth/wei0.60614320
165MP0003705_abnormal_hypodermis_morpholog0.60203382
166MP0001664_abnormal_digestion0.59968190
167MP0002998_abnormal_bone_remodeling0.59660688
168MP0002295_abnormal_pulmonary_circulatio0.59585994
169MP0000534_abnormal_ureter_morphology0.59441417
170MP0002234_abnormal_pharynx_morphology0.59421092
171MP0001340_abnormal_eyelid_morphology0.58440753
172MP0002116_abnormal_craniofacial_bone0.56525636
173MP0002109_abnormal_limb_morphology0.55654465
174MP0006138_congestive_heart_failure0.55414704
175MP0002177_abnormal_outer_ear0.53921460

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.51031518
2Myokymia (HP:0002411)5.30743777
3Focal seizures (HP:0007359)5.07762780
4Aortic aneurysm (HP:0004942)5.03127173
5Aortic dissection (HP:0002647)4.93048009
6Visual hallucinations (HP:0002367)4.67581480
7Atonic seizures (HP:0010819)4.44741323
8Ankle contracture (HP:0006466)4.12548018
9Type 1 muscle fiber predominance (HP:0003803)4.06765712
10Soft skin (HP:0000977)3.86400398
11Follicular hyperkeratosis (HP:0007502)3.83264434
12Epileptic encephalopathy (HP:0200134)3.69444543
13Absence seizures (HP:0002121)3.65997813
14Wormian bones (HP:0002645)3.59647431
15Atrophic scars (HP:0001075)3.50222035
16Febrile seizures (HP:0002373)3.48181387
17Progressive cerebellar ataxia (HP:0002073)3.45152090
18Abnormality of dentin (HP:0010299)3.40233232
19Action tremor (HP:0002345)3.31746297
20Bladder diverticulum (HP:0000015)3.30211870
21Generalized tonic-clonic seizures (HP:0002069)3.25681442
22Dialeptic seizures (HP:0011146)3.24018089
23Spinal rigidity (HP:0003306)3.19413474
24Slender build (HP:0001533)3.19396568
25Spondylolisthesis (HP:0003302)3.15877077
26Fragile skin (HP:0001030)3.14970619
27Genu recurvatum (HP:0002816)3.10114150
28Peritonitis (HP:0002586)3.10048952
29Papilledema (HP:0001085)3.07815269
30Spinal cord lesions (HP:0100561)3.06393194
31Syringomyelia (HP:0003396)3.06393194
32Neonatal short-limb short stature (HP:0008921)3.05079800
33Supranuclear gaze palsy (HP:0000605)3.04012638
34Truncal ataxia (HP:0002078)3.03332897
35Ankle clonus (HP:0011448)3.00191317
36Aortic regurgitation (HP:0001659)2.99913109
37Cervical subluxation (HP:0003308)2.97658631
38Depression (HP:0000716)2.95639423
39Mitral valve prolapse (HP:0001634)2.91288992
40Vertebral compression fractures (HP:0002953)2.78312735
41Dysdiadochokinesis (HP:0002075)2.76184366
42Gaze-evoked nystagmus (HP:0000640)2.75282767
43Anxiety (HP:0000739)2.71728068
44Coronal craniosynostosis (HP:0004440)2.71691624
45Broad-based gait (HP:0002136)2.70848508
46Mesomelia (HP:0003027)2.70120144
47Dysmetria (HP:0001310)2.69031108
48Poor eye contact (HP:0000817)2.66829520
49Impaired vibration sensation in the lower limbs (HP:0002166)2.66559153
50Blue sclerae (HP:0000592)2.65213776
51Bowel diverticulosis (HP:0005222)2.63783473
52Protrusio acetabuli (HP:0003179)2.61129334
53Joint laxity (HP:0001388)2.59771150
54Osteolytic defects of the hand bones (HP:0009699)2.57785377
55Osteolytic defects of the phalanges of the hand (HP:0009771)2.57785377
56Hyperextensible skin (HP:0000974)2.55015188
57Biconcave vertebral bodies (HP:0004586)2.54673011
58Hyperventilation (HP:0002883)2.51980844
59Mitral stenosis (HP:0001718)2.51809175
60Impaired social interactions (HP:0000735)2.50821263
61Abnormal social behavior (HP:0012433)2.50821263
62Dysmetric saccades (HP:0000641)2.50246907
63Urinary bladder sphincter dysfunction (HP:0002839)2.49753250
64Scanning speech (HP:0002168)2.47607450
65Genetic anticipation (HP:0003743)2.47567984
66Elbow flexion contracture (HP:0002987)2.46656592
67Round ear (HP:0100830)2.46640941
68Mildly elevated creatine phosphokinase (HP:0008180)2.45366569
69Mitral regurgitation (HP:0001653)2.43968348
70Torticollis (HP:0000473)2.42787875
71Absent frontal sinuses (HP:0002688)2.42676455
72Cerebral inclusion bodies (HP:0100314)2.42453464
73Mutism (HP:0002300)2.42056808
74Abnormal eating behavior (HP:0100738)2.39338134
75Insidious onset (HP:0003587)2.38168877
76Termporal pattern (HP:0011008)2.38168877
77Sparse lateral eyebrow (HP:0005338)2.33350244
78Postural instability (HP:0002172)2.31519492
79Urinary urgency (HP:0000012)2.30337837
80Mild short stature (HP:0003502)2.28879076
81Abnormality of skeletal muscle fiber size (HP:0012084)2.28444881
82Short nail (HP:0001799)2.26911236
83Neurofibrillary tangles (HP:0002185)2.25861208
84Lower limb amyotrophy (HP:0007210)2.25789543
85Resting tremor (HP:0002322)2.25486768
86Aneurysm (HP:0002617)2.24409119
87Impaired smooth pursuit (HP:0007772)2.24060563
88Wide anterior fontanel (HP:0000260)2.24011621
89Pheochromocytoma (HP:0002666)2.23784746
90Amblyopia (HP:0000646)2.22777220
91Premature rupture of membranes (HP:0001788)2.22017010
92Abnormal delivery (HP:0001787)2.21495065
93Cardiovascular calcification (HP:0011915)2.19847265
94Buphthalmos (HP:0000557)2.18524789
95Spastic gait (HP:0002064)2.16705060
96Hypoventilation (HP:0002791)2.14032029
97Progressive inability to walk (HP:0002505)2.13454569
98Megalencephaly (HP:0001355)2.13379619
99Ulnar bowing (HP:0003031)2.12685309
100Stereotypic behavior (HP:0000733)2.11987035
101Focal dystonia (HP:0004373)2.10202950
102Ankyloglossia (HP:0010296)2.09503747
103Limb dystonia (HP:0002451)2.04929316
104Abnormality of binocular vision (HP:0011514)2.04048946
105Diplopia (HP:0000651)2.04048946
106Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.03674988
107Abnormality of the acetabulum (HP:0003170)2.03298364
108Striae distensae (HP:0001065)2.02684766
109Rapidly progressive (HP:0003678)2.02270230
110Increased variability in muscle fiber diameter (HP:0003557)2.00586458
111Hemiplegia (HP:0002301)2.00437981
112Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.99368345
113Neuroendocrine neoplasm (HP:0100634)1.99027397
114Excessive salivation (HP:0003781)1.98035085
115Drooling (HP:0002307)1.98035085
116Intention tremor (HP:0002080)1.97981282
117Delayed closure of the anterior fontanelle (HP:0001476)1.97129806
118Annular pancreas (HP:0001734)1.97057312
119Bradykinesia (HP:0002067)1.95977076
120Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.95897608
121Hypoplasia of the iris (HP:0007676)1.95563334
122Shallow orbits (HP:0000586)1.95411535
123Persistence of primary teeth (HP:0006335)1.93247404
124Aortic valve stenosis (HP:0001650)1.93193974
125Vascular tortuosity (HP:0004948)1.93192545
126Craniofacial dystonia (HP:0012179)1.92532209
127Overgrowth (HP:0001548)1.92119723
128Limb-girdle muscle weakness (HP:0003325)1.91333844
129Broad ribs (HP:0000885)1.90321788
130Arterial tortuosity (HP:0005116)1.90214748
131Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.90120237
132Camptodactyly of toe (HP:0001836)1.89353649
133Thoracolumbar scoliosis (HP:0002944)1.89229044
134Abnormality of ocular smooth pursuit (HP:0000617)1.88931281
135Neuronal loss in central nervous system (HP:0002529)1.88702855
136Absent speech (HP:0001344)1.87677669
137Generalized myoclonic seizures (HP:0002123)1.87652672
138Lower limb muscle weakness (HP:0007340)1.87474392
139Increased connective tissue (HP:0009025)1.87136462
140Pointed chin (HP:0000307)1.86692166
141Epileptiform EEG discharges (HP:0011182)1.85348965
142Relative macrocephaly (HP:0004482)1.83970513
143Wrist flexion contracture (HP:0001239)1.83726486
144Ventricular fibrillation (HP:0001663)1.82410319
145Bronchomalacia (HP:0002780)1.81888279
146Agitation (HP:0000713)1.81278165
147Hemiparesis (HP:0001269)1.80749558
148Neoplasm of the peripheral nervous system (HP:0100007)1.80514016
149Abnormality of the lower motor neuron (HP:0002366)1.79365983
150EEG with generalized epileptiform discharges (HP:0011198)1.78821060
151Aplasia involving bones of the extremities (HP:0009825)1.77685052
152Aplasia involving bones of the upper limbs (HP:0009823)1.77685052
153Aplasia of the phalanges of the hand (HP:0009802)1.77685052
154Abnormality of oral frenula (HP:0000190)1.77595411
155Achilles tendon contracture (HP:0001771)1.77201367
156Status epilepticus (HP:0002133)1.74948050
157Broad metatarsal (HP:0001783)1.74892518
158Obstructive sleep apnea (HP:0002870)1.74824849
159Deviation of the hallux (HP:0010051)1.74705883
160Hypercortisolism (HP:0001578)1.74556190
161Impaired vibratory sensation (HP:0002495)1.74481107
162Lower limb asymmetry (HP:0100559)1.73985497
163Dilatation of the ascending aorta (HP:0005111)1.73928383
164Disproportionate tall stature (HP:0001519)1.73633737
165Vertebral arch anomaly (HP:0008438)1.73623302
166Ectopia lentis (HP:0001083)1.73138557
167Cerebral aneurysm (HP:0004944)1.72885182
168Breech presentation (HP:0001623)1.71426635
169Bradycardia (HP:0001662)1.70617702
170Knee flexion contracture (HP:0006380)1.70331170
171Narrow palate (HP:0000189)1.69412804
172Delayed cranial suture closure (HP:0000270)1.69229556
173Short middle phalanx of the 5th finger (HP:0004220)1.67500635
174Abnormality of skull ossification (HP:0002703)1.67082449
175Reduced subcutaneous adipose tissue (HP:0003758)1.66766037
176Abnormality of the frontal sinuses (HP:0002687)1.65422170
177Ovoid vertebral bodies (HP:0003300)1.65104490
178Abnormality of the epiphyses of the hand (HP:0005924)1.64588116
179Hallux valgus (HP:0001822)1.63294977
180Limited hip movement (HP:0008800)1.61311382
181Inguinal hernia (HP:0000023)1.59372604
182Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.59125716
183Generalized amyotrophy (HP:0003700)1.58690127
184Protruding ear (HP:0000411)1.58444313
185Decreased skull ossification (HP:0004331)1.58268142
186Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.58242199
187Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.58080954
188Joint stiffness (HP:0001387)1.57691806
189Long eyelashes (HP:0000527)1.56307073

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT34.54847473
2NTRK34.04540934
3MYLK4.03118079
4EPHA43.85068834
5MAP3K93.68932680
6NEK93.54791175
7LATS12.77450927
8MAP3K42.64532406
9MINK12.49780798
10PRKD32.49186346
11PAK62.41801622
12FLT32.38185428
13PAK22.31826184
14KSR22.30605454
15NTRK12.24798798
16CAMKK12.03243391
17DAPK22.02976943
18MAP2K72.00570477
19MARK11.94854211
20MAP3K121.90992098
21MAP2K41.84118276
22RIPK41.81795580
23TGFBR21.77115418
24MET1.71814836
25CDK191.70591711
26LATS21.68039271
27CAMKK21.59544962
28CDK121.58703451
29NTRK21.57979186
30ARAF1.55155097
31CDK51.54385911
32PDGFRB1.53589345
33PIK3CG1.52892112
34KSR11.45267026
35PLK21.43700076
36TRPM71.40800338
37MAP3K61.36585862
38MAP3K21.36528054
39ERBB41.35957541
40MAP3K131.32563351
41FES1.29338190
42KIT1.26682458
43STK381.26359659
44DDR21.22508344
45RET1.19998743
46GRK51.16984286
47PTK2B1.15617430
48CASK1.13653452
49PAK31.11826350
50ERBB31.09991576
51SIK21.08877866
52DAPK11.08685341
53UHMK11.06483386
54PRKCH1.04366635
55OXSR11.03863003
56PRPF4B1.03555533
57PNCK1.01083447
58FER1.01075803
59TNIK1.00945700
60WNK11.00817905
61SIK10.99958280
62CAMK2A0.99422283
63STK30.98367804
64CDK140.97684667
65TAOK10.97352241
66PRKCG0.96328556
67STK38L0.95609087
68ABL20.94518548
69CDK150.94146259
70CDK180.93597426
71TYRO30.92431342
72CAMK10.92166109
73ICK0.90803557
74FGFR30.90789492
75MAPK70.87834901
76STK110.86800089
77MAPK130.86642673
78SCYL20.84690710
79RPS6KA20.83838294
80RAF10.83090970
81MAP3K10.82659377
82MELK0.82543571
83CDK60.81534010
84CSNK1G20.81487344
85CDK11A0.80870170
86CAMK2B0.80732026
87DMPK0.80358198
88RIPK10.79771064
89MTOR0.79045702
90PDGFRA0.78842143
91SGK4940.77767862
92SGK2230.77767862
93MOS0.77558005
94MAPKAPK50.76991583
95STK390.75126131
96MAP2K10.73900471
97MAP2K30.73071928
98MARK20.71991315
99PDPK10.71458076
100TESK10.71213960
101GRK70.70824220
102JAK10.70390421
103PAK40.70361525
104PHKG20.70171904
105PHKG10.70171904
106PRKG20.67400373
107PDK10.66713650
108ROCK10.66589595
109TRIB30.66212302
110ROCK20.65071627
111CAMK1G0.64997137
112CAMK2D0.63416188
113GSK3A0.62725954
114ERN10.62532328
115SGK10.60949907
116PRKCE0.60543532
117ALK0.60321419
118BRD40.59790401
119BRSK20.59182216
120MAP3K70.56554857
121CDK90.55581775
122PTK20.54761885
123SGK30.54470823
124FYN0.53688903
125TTN0.52472853
126LMTK20.51437978
127RPS6KL10.51244959
128RPS6KC10.51244959
129WNK40.51085810
130SGK20.50099578
131FGR0.48758214
132CAMK2G0.47507720
133HIPK20.46946343
134TNK20.46357333
135TAOK20.45917676
136FGFR10.45838946
137DYRK1A0.45817818
138CDK80.45628325
139RPS6KA30.45217801
140CDC42BPA0.44931616
141BMX0.44355742
142DAPK30.43607697
143NLK0.43166785
144LIMK10.42387300
145MAPK100.42248853
146PRKD20.42179367
147BMPR20.41988704
148MST1R0.41772382
149ADRBK10.40288788
150PKN20.39773875
151FGFR40.38138809
152EEF2K0.36680352
153RPS6KB10.35512496
154PRKD10.34796801
155EPHA30.31950905
156RPS6KA60.28023794
157TIE10.27796757
158MAP3K30.27461807

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.97644106
2Nicotine addiction_Homo sapiens_hsa050332.89816443
3Olfactory transduction_Homo sapiens_hsa047402.53614494
4GABAergic synapse_Homo sapiens_hsa047272.45440078
5Circadian entrainment_Homo sapiens_hsa047132.37587760
6Long-term potentiation_Homo sapiens_hsa047202.36979309
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.35126007
8Amphetamine addiction_Homo sapiens_hsa050312.23073076
9Morphine addiction_Homo sapiens_hsa050322.21545149
10Glutamatergic synapse_Homo sapiens_hsa047242.21457299
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.08788711
12Dopaminergic synapse_Homo sapiens_hsa047282.04724730
13Salivary secretion_Homo sapiens_hsa049701.91792613
14Cholinergic synapse_Homo sapiens_hsa047251.81955743
15Insulin secretion_Homo sapiens_hsa049111.81857369
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.77289807
17Gastric acid secretion_Homo sapiens_hsa049711.76670367
18Protein digestion and absorption_Homo sapiens_hsa049741.76294383
19Cocaine addiction_Homo sapiens_hsa050301.71655511
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64547405
21Renin secretion_Homo sapiens_hsa049241.59675422
22Oxytocin signaling pathway_Homo sapiens_hsa049211.59570445
23Serotonergic synapse_Homo sapiens_hsa047261.58440993
24Taste transduction_Homo sapiens_hsa047421.58309403
25Long-term depression_Homo sapiens_hsa047301.57935007
26Adherens junction_Homo sapiens_hsa045201.57772173
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.57644211
28TGF-beta signaling pathway_Homo sapiens_hsa043501.49306705
29GnRH signaling pathway_Homo sapiens_hsa049121.46919382
30Hippo signaling pathway_Homo sapiens_hsa043901.42705277
31Small cell lung cancer_Homo sapiens_hsa052221.42450918
32Gap junction_Homo sapiens_hsa045401.42441360
33Calcium signaling pathway_Homo sapiens_hsa040201.40753498
34Collecting duct acid secretion_Homo sapiens_hsa049661.39381302
35Chronic myeloid leukemia_Homo sapiens_hsa052201.39003804
36MicroRNAs in cancer_Homo sapiens_hsa052061.35713928
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33261627
38PI3K-Akt signaling pathway_Homo sapiens_hsa041511.26267697
39Glioma_Homo sapiens_hsa052141.23630273
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21922239
41Circadian rhythm_Homo sapiens_hsa047101.21228664
42Estrogen signaling pathway_Homo sapiens_hsa049151.20104401
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19843299
44Central carbon metabolism in cancer_Homo sapiens_hsa052301.18817109
45Vibrio cholerae infection_Homo sapiens_hsa051101.18743966
46cAMP signaling pathway_Homo sapiens_hsa040241.18580977
47Hedgehog signaling pathway_Homo sapiens_hsa043401.16546020
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.12600503
49Axon guidance_Homo sapiens_hsa043601.10941754
50Dilated cardiomyopathy_Homo sapiens_hsa054141.10533620
51Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06485562
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05620515
53Type II diabetes mellitus_Homo sapiens_hsa049301.05573182
54cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04381209
55ErbB signaling pathway_Homo sapiens_hsa040121.03506487
56Pathways in cancer_Homo sapiens_hsa052001.02480596
57Melanogenesis_Homo sapiens_hsa049161.02407861
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.01138968
59Prostate cancer_Homo sapiens_hsa052150.99766461
60Dorso-ventral axis formation_Homo sapiens_hsa043200.99561710
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.97259797
62Pancreatic cancer_Homo sapiens_hsa052120.96057430
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95603430
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92982880
65Bladder cancer_Homo sapiens_hsa052190.91681091
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.90734686
67Cardiac muscle contraction_Homo sapiens_hsa042600.86509885
68Basal cell carcinoma_Homo sapiens_hsa052170.85862328
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85369575
70Phototransduction_Homo sapiens_hsa047440.85234502
71Thyroid hormone synthesis_Homo sapiens_hsa049180.84711570
72Pancreatic secretion_Homo sapiens_hsa049720.80137365
73Rap1 signaling pathway_Homo sapiens_hsa040150.77119477
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76961454
75VEGF signaling pathway_Homo sapiens_hsa043700.76757436
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76336794
77MAPK signaling pathway_Homo sapiens_hsa040100.76246116
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.73055694
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72016846
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71294216
81Ras signaling pathway_Homo sapiens_hsa040140.70343874
82Colorectal cancer_Homo sapiens_hsa052100.69680056
83FoxO signaling pathway_Homo sapiens_hsa040680.69604303
84Oocyte meiosis_Homo sapiens_hsa041140.69119549
85Renal cell carcinoma_Homo sapiens_hsa052110.68863565
86Prion diseases_Homo sapiens_hsa050200.68800489
87Endocytosis_Homo sapiens_hsa041440.67885205
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.67822311
89Thyroid cancer_Homo sapiens_hsa052160.67760630
90Choline metabolism in cancer_Homo sapiens_hsa052310.66827328
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65299548
92* Prolactin signaling pathway_Homo sapiens_hsa049170.63449672
93Shigellosis_Homo sapiens_hsa051310.62781182
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.62421511
95Focal adhesion_Homo sapiens_hsa045100.61965618
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60205420
97mTOR signaling pathway_Homo sapiens_hsa041500.59957723
98Glucagon signaling pathway_Homo sapiens_hsa049220.58335563
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57693032
100Platelet activation_Homo sapiens_hsa046110.56447096
101Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56248705
102Non-small cell lung cancer_Homo sapiens_hsa052230.53573493
103Malaria_Homo sapiens_hsa051440.52632923
104Nitrogen metabolism_Homo sapiens_hsa009100.52614348
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51004004
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50101996
107ECM-receptor interaction_Homo sapiens_hsa045120.49941135
108Proteoglycans in cancer_Homo sapiens_hsa052050.49586598
109Endometrial cancer_Homo sapiens_hsa052130.49343675
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49194657
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47962120
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47598840
113Inositol phosphate metabolism_Homo sapiens_hsa005620.47539846
114Type I diabetes mellitus_Homo sapiens_hsa049400.47051146
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47026998
116Wnt signaling pathway_Homo sapiens_hsa043100.46670730
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46127452
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44845613
119Amoebiasis_Homo sapiens_hsa051460.44448009
120Alcoholism_Homo sapiens_hsa050340.44142909
121Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44094149
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44090688
123Ovarian steroidogenesis_Homo sapiens_hsa049130.43360330
124Insulin signaling pathway_Homo sapiens_hsa049100.43124748
125Tight junction_Homo sapiens_hsa045300.41550925
126AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39630367
127Melanoma_Homo sapiens_hsa052180.38496806

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