SOCS5P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of smooth muscle cell differentiation (GO:0051151)9.90040349
2positive regulation of fatty acid beta-oxidation (GO:0032000)7.61942142
3positive regulation of fatty acid oxidation (GO:0046321)6.55144778
4male sex determination (GO:0030238)5.40067185
5regulation of histone phosphorylation (GO:0033127)5.28849887
6regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)5.16429528
7protein import into peroxisome matrix (GO:0016558)5.14795080
8catecholamine transport (GO:0051937)5.01613012
9dopamine transport (GO:0015872)4.72137273
10platelet dense granule organization (GO:0060155)4.64685589
11regulation of smooth muscle cell differentiation (GO:0051150)4.64236208
12startle response (GO:0001964)4.58446584
13behavioral response to nicotine (GO:0035095)4.58177595
14meiotic chromosome segregation (GO:0045132)4.55125808
15positive regulation of neurotransmitter secretion (GO:0001956)4.51023869
16gamma-aminobutyric acid transport (GO:0015812)4.34868092
17negative regulation of histone methylation (GO:0031061)4.34229732
18inositol metabolic process (GO:0006020)4.27807698
19bile acid and bile salt transport (GO:0015721)4.26718756
20oligosaccharide metabolic process (GO:0009311)4.24357468
21cellular response to pH (GO:0071467)4.15874134
22regulation of respiratory system process (GO:0044065)4.11338264
23positive regulation of CREB transcription factor activity (GO:0032793)4.07294662
24regulation of fatty acid beta-oxidation (GO:0031998)4.05542718
25phosphatidylinositol acyl-chain remodeling (GO:0036149)4.00747687
26positive regulation of synapse assembly (GO:0051965)3.99697661
27inner mitochondrial membrane organization (GO:0007007)3.99304415
28suckling behavior (GO:0001967)3.94242103
29presynaptic membrane organization (GO:0097090)3.88951365
30left/right pattern formation (GO:0060972)3.88822264
31regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.86357087
32presynaptic membrane assembly (GO:0097105)3.79450321
33peroxisome fission (GO:0016559)3.71898912
34chaperone-mediated protein complex assembly (GO:0051131)3.62940423
35regulation of appetite (GO:0032098)3.61884786
36opioid receptor signaling pathway (GO:0038003)3.60470977
37protein localization to synapse (GO:0035418)3.57786811
38regulation of timing of cell differentiation (GO:0048505)3.45376738
39positive regulation of neurotransmitter transport (GO:0051590)3.43130840
40regulation of sequestering of triglyceride (GO:0010889)3.35580795
41regulation of synapse assembly (GO:0051963)3.32432229
42neuromuscular synaptic transmission (GO:0007274)3.30010011
43negative regulation of sodium ion transport (GO:0010766)3.23991448
44neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.23712153
45regulation of development, heterochronic (GO:0040034)3.23078203
46transmission of nerve impulse (GO:0019226)3.22678984
47cysteine metabolic process (GO:0006534)3.19237389
48ribosomal small subunit assembly (GO:0000028)3.17639670
49indole-containing compound catabolic process (GO:0042436)3.14062863
50indolalkylamine catabolic process (GO:0046218)3.14062863
51tryptophan catabolic process (GO:0006569)3.14062863
52negative regulation of histone acetylation (GO:0035067)3.13382510
53positive regulation of lipid catabolic process (GO:0050996)3.12841249
542-oxoglutarate metabolic process (GO:0006103)3.07908579
55regulation of mitochondrial translation (GO:0070129)3.07773481
56tryptophan metabolic process (GO:0006568)3.01420045
57histone-serine phosphorylation (GO:0035404)3.01201330
58regulation of respiratory gaseous exchange (GO:0043576)2.99200933
59aldehyde catabolic process (GO:0046185)2.98852428
60protein targeting to peroxisome (GO:0006625)2.97756086
61establishment of protein localization to peroxisome (GO:0072663)2.97756086
62protein localization to peroxisome (GO:0072662)2.97756086
63maturation of SSU-rRNA (GO:0030490)2.96648596
64negative regulation of fatty acid transport (GO:2000192)2.96563116
65regulation of nuclear cell cycle DNA replication (GO:0033262)2.95094503
66sequestering of actin monomers (GO:0042989)2.91520685
67alanine transport (GO:0032328)2.89665951
68interleukin-1-mediated signaling pathway (GO:0070498)2.83774528
69response to pheromone (GO:0019236)2.82723084
70protein complex biogenesis (GO:0070271)2.82508200
71regulation of triglyceride catabolic process (GO:0010896)2.80135073
72ventricular system development (GO:0021591)2.78652886
73oxidative phosphorylation (GO:0006119)2.76754266
74intracellular protein transmembrane import (GO:0044743)2.76507110
75negative regulation of axon extension (GO:0030517)2.76163518
76regulation of fatty acid oxidation (GO:0046320)2.72915092
77fear response (GO:0042596)2.72127132
78regulation of axon extension involved in axon guidance (GO:0048841)2.72111343
79monoamine transport (GO:0015844)2.71685649
80spinal cord motor neuron differentiation (GO:0021522)2.70346849
81lung secretory cell differentiation (GO:0061140)2.68140927
82behavioral fear response (GO:0001662)2.65909867
83behavioral defense response (GO:0002209)2.65909867
84peroxisomal transport (GO:0043574)2.65628593
85sex determination (GO:0007530)2.65208234
86cardiolipin metabolic process (GO:0032048)2.64940780
87anterograde synaptic vesicle transport (GO:0048490)2.64902866
88peripheral nervous system axon ensheathment (GO:0032292)2.64617855
89myelination in peripheral nervous system (GO:0022011)2.64617855
90multicellular organism reproduction (GO:0032504)2.63763668
91neuronal stem cell maintenance (GO:0097150)2.62654184
92regulation of short-term neuronal synaptic plasticity (GO:0048172)2.61336610
93regulation of synapse organization (GO:0050807)2.61260401
94negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.61113956
95phosphatidylserine acyl-chain remodeling (GO:0036150)2.60416496
96intracellular protein transmembrane transport (GO:0065002)2.59332384
97phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.55826547
98regulation of axon guidance (GO:1902667)2.55464388
99N-acetylglucosamine metabolic process (GO:0006044)2.54637215
100oligosaccharide biosynthetic process (GO:0009312)15.4954433

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1AR_21572438_ChIP-Seq_LNCaP_Human5.25440798
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.99036136
3ZNF274_21170338_ChIP-Seq_K562_Hela3.62237040
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.43003904
5EZH2_22144423_ChIP-Seq_EOC_Human3.36287439
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.01218017
7GBX2_23144817_ChIP-Seq_PC3_Human2.93379136
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.75634006
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.19378801
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.18548187
11CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.93602460
12CBX2_27304074_Chip-Seq_ESCs_Mouse1.91872110
13JARID2_20064375_ChIP-Seq_MESCs_Mouse1.91819835
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.90253514
15CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87649090
16RNF2_27304074_Chip-Seq_NSC_Mouse1.86580955
17EZH2_27304074_Chip-Seq_ESCs_Mouse1.82125668
18ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79856527
19MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.77995220
20EZH2_27294783_Chip-Seq_ESCs_Mouse1.70606116
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69250878
22DROSHA_22980978_ChIP-Seq_HELA_Human1.68777858
23SOX2_19829295_ChIP-Seq_ESCs_Human1.67762850
24NANOG_19829295_ChIP-Seq_ESCs_Human1.67762850
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.66379930
26REST_21632747_ChIP-Seq_MESCs_Mouse1.64664385
27AR_25329375_ChIP-Seq_VCAP_Human1.63268423
28POU5F1_16153702_ChIP-ChIP_HESCs_Human1.62010062
29PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.60585104
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.59687654
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.56461969
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.55319492
33MYC_18940864_ChIP-ChIP_HL60_Human1.55259874
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.52257403
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.50387722
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.45815680
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.44115007
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41500974
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40886668
40CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.40142434
41P300_19829295_ChIP-Seq_ESCs_Human1.38453325
42RNF2_18974828_ChIP-Seq_MESCs_Mouse1.38238165
43EZH2_18974828_ChIP-Seq_MESCs_Mouse1.38238165
44TCF4_23295773_ChIP-Seq_U87_Human1.35558104
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35028903
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34547550
47GATA3_21878914_ChIP-Seq_MCF-7_Human1.32581787
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31552103
49IGF1R_20145208_ChIP-Seq_DFB_Human1.31195197
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.30832855
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.30520499
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29709061
53NCOR_22424771_ChIP-Seq_293T_Human1.29384672
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29054017
55JARID2_20075857_ChIP-Seq_MESCs_Mouse1.28120714
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25848567
57GATA1_26923725_Chip-Seq_HPCs_Mouse1.25725653
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23665767
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23407566
60CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.22273331
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21365952
62RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.21134843
63TP53_22573176_ChIP-Seq_HFKS_Human1.20182471
64CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.19073510
65ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18149374
66SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17958128
67ER_23166858_ChIP-Seq_MCF-7_Human1.13488530
68SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.13341332
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12757781
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12669150
71EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.12622405
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11000040
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10584016
74OCT1_27270436_Chip-Seq_PROSTATE_Human1.09504111
75STAT3_23295773_ChIP-Seq_U87_Human1.09138376
76PRDM14_20953172_ChIP-Seq_ESCs_Human1.08836147
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.08729693
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.08520464
79NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08141879
80FLI1_21867929_ChIP-Seq_TH2_Mouse1.08019131
81RUNX2_22187159_ChIP-Seq_PCA_Human1.06915098
82STAT1_17558387_ChIP-Seq_HELA_Human1.06330480
83AR_20517297_ChIP-Seq_VCAP_Human1.05417124
84CBP_20019798_ChIP-Seq_JUKART_Human1.05146749
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05146749
86MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03290511
87MYC_19829295_ChIP-Seq_ESCs_Human1.02514946
88LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02246471
89FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99760861
90SOX2_16153702_ChIP-ChIP_HESCs_Human0.98941498
91EWS_26573619_Chip-Seq_HEK293_Human0.97726463
92FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96338835
93FOXA1_25329375_ChIP-Seq_VCAP_Human0.96338835
94WDR5_24793694_ChIP-Seq_LNCAP_Human0.95576850
95IRF1_19129219_ChIP-ChIP_H3396_Human0.94634994
96P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93669013
97KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92389073
98ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90216512
99CBX2_22325352_ChIP-Seq_293T-Rex_Human0.90175955
100FUS_26573619_Chip-Seq_HEK293_Human0.88161068

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ4.93008604
2MP0000566_synostosis3.62547517
3MP0005423_abnormal_somatic_nervous3.03730001
4MP0003011_delayed_dark_adaptation2.93175653
5MP0004885_abnormal_endolymph2.71274930
6MP0004130_abnormal_muscle_cell2.63313863
7MP0008961_abnormal_basal_metabolism2.47871198
8MP0004133_heterotaxia2.46820884
9MP0001529_abnormal_vocalization2.36442641
10MP0009379_abnormal_foot_pigmentation2.32938298
11MP0001968_abnormal_touch/_nociception2.17026372
12MP0003880_abnormal_central_pattern2.15546634
13MP0002733_abnormal_thermal_nociception2.07786369
14MP0003646_muscle_fatigue2.04995695
15MP0000569_abnormal_digit_pigmentation1.99590739
16MP0001502_abnormal_circadian_rhythm1.97746943
17MP0005386_behavior/neurological_phenoty1.96068728
18MP0004924_abnormal_behavior1.96068728
19MP0002735_abnormal_chemical_nociception1.95637378
20MP0005360_urolithiasis1.94739372
21MP0001986_abnormal_taste_sensitivity1.92783124
22MP0004147_increased_porphyrin_level1.85010348
23MP0001486_abnormal_startle_reflex1.83726562
24MP0001970_abnormal_pain_threshold1.82291378
25MP0008875_abnormal_xenobiotic_pharmacok1.76746165
26MP0005551_abnormal_eye_electrophysiolog1.75646955
27MP0002734_abnormal_mechanical_nocicepti1.74181118
28MP0009745_abnormal_behavioral_response1.71006585
29MP0005448_abnormal_energy_balance1.69215333
30MP0005646_abnormal_pituitary_gland1.66591031
31MP0004142_abnormal_muscle_tone1.65388115
32MP0006276_abnormal_autonomic_nervous1.64803281
33MP0004742_abnormal_vestibular_system1.59511540
34MP0005503_abnormal_tendon_morphology1.56094104
35MP0005076_abnormal_cell_differentiation1.52677948
36MP0004145_abnormal_muscle_electrophysio1.52134791
37MP0010030_abnormal_orbit_morphology1.49959571
38MP0003567_abnormal_fetal_cardiomyocyte1.49201535
39MP0004043_abnormal_pH_regulation1.47690779
40MP0002938_white_spotting1.45674673
41MP0002653_abnormal_ependyma_morphology1.45577167
42MP0009046_muscle_twitch1.43936139
43MP0003635_abnormal_synaptic_transmissio1.43122524
44MP0002277_abnormal_respiratory_mucosa1.42229284
45MP0000778_abnormal_nervous_system1.42077125
46MP0003136_yellow_coat_color1.37854188
47MP0002063_abnormal_learning/memory/cond1.36146232
48MP0002572_abnormal_emotion/affect_behav1.31500532
49MP0002557_abnormal_social/conspecific_i1.30696841
50MP0000631_abnormal_neuroendocrine_gland1.28774117
51MP0000534_abnormal_ureter_morphology1.26109012
52MP0002837_dystrophic_cardiac_calcinosis1.24643752
53MP0001963_abnormal_hearing_physiology1.23792604
54MP0004019_abnormal_vitamin_homeostasis1.21869760
55MP0001485_abnormal_pinna_reflex1.21198286
56MP0001501_abnormal_sleep_pattern1.21065779
57MP0003137_abnormal_impulse_conducting1.18906226
58MP0002069_abnormal_eating/drinking_beha1.18839343
59MP0005253_abnormal_eye_physiology1.13391923
60MP0008872_abnormal_physiological_respon1.10331565
61MP0001664_abnormal_digestion1.06044120
62MP0000371_diluted_coat_color1.05639684
63MP0008995_early_reproductive_senescence1.04696590
64MP0005171_absent_coat_pigmentation1.02258001
65MP0005084_abnormal_gallbladder_morpholo1.01755496
66MP0002064_seizures1.01574978
67MP0002736_abnormal_nociception_after1.01239843
68MP0000372_irregular_coat_pigmentation0.99954116
69MP0000026_abnormal_inner_ear0.97068336
70MP0004215_abnormal_myocardial_fiber0.95966039
71MP0003937_abnormal_limbs/digits/tail_de0.94859601
72MP0003861_abnormal_nervous_system0.94192422
73MP0001958_emphysema0.92649168
74MP0010386_abnormal_urinary_bladder0.92295827
75MP0001929_abnormal_gametogenesis0.92033601
76MP0005595_abnormal_vascular_smooth0.88448328
77MP0002067_abnormal_sensory_capabilities0.88111527
78MP0006072_abnormal_retinal_apoptosis0.87686678
79MP0002272_abnormal_nervous_system0.87120615
80MP0006292_abnormal_olfactory_placode0.85988474
81MP0005310_abnormal_salivary_gland0.84398520
82MP0005187_abnormal_penis_morphology0.82526710
83MP0002971_abnormal_brown_adipose0.79868283
84MP0002210_abnormal_sex_determination0.78854263
85MP0001944_abnormal_pancreas_morphology0.78836023
86MP0003890_abnormal_embryonic-extraembry0.78306850
87MP0005195_abnormal_posterior_eye0.78180444
88MP0002152_abnormal_brain_morphology0.78156487
89MP0001873_stomach_inflammation0.77549204
90MP0005381_digestive/alimentary_phenotyp0.76546341
91MP0003638_abnormal_response/metabolism_0.76174047
92MP0002089_abnormal_postnatal_growth/wei0.76084618
93MP0003698_abnormal_male_reproductive0.76077769
94MP0003195_calcinosis0.75687136
95MP0001663_abnormal_digestive_system0.74804680
96MP0000653_abnormal_sex_gland0.74356590
97MP0002108_abnormal_muscle_morphology0.72708561
98MP0002282_abnormal_trachea_morphology0.72707330
99MP0002882_abnormal_neuron_morphology0.72150096
100MP0009115_abnormal_fat_cell0.71015668

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.73242767
2Turricephaly (HP:0000262)5.43628309
3Protruding tongue (HP:0010808)5.11624154
4Renal cortical cysts (HP:0000803)4.43814668
5Bell-shaped thorax (HP:0001591)4.33660418
6Brushfield spots (HP:0001088)4.26584724
7Abnormal number of erythroid precursors (HP:0012131)4.13250695
8Large for gestational age (HP:0001520)3.88263725
9Abnormality of cells of the erythroid lineage (HP:0012130)3.74054248
10Global brain atrophy (HP:0002283)3.71110211
11Hyperventilation (HP:0002883)3.60246836
12Flat occiput (HP:0005469)3.58361230
13Abnormality of the renal cortex (HP:0011035)3.42347477
14Type II lissencephaly (HP:0007260)3.40176346
15Broad metatarsal (HP:0001783)3.38807602
16Infantile muscular hypotonia (HP:0008947)3.28433902
17Patellar aplasia (HP:0006443)3.00635212
18Hypoplastic ischia (HP:0003175)2.96782171
19Focal motor seizures (HP:0011153)2.94837146
20Clumsiness (HP:0002312)2.90676299
21Tubulointerstitial nephritis (HP:0001970)2.89288365
22Breast hypoplasia (HP:0003187)2.81842253
23Intellectual disability, progressive (HP:0006887)2.80928643
24Redundant skin (HP:0001582)2.80171427
25Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.78490712
26Spastic tetraparesis (HP:0001285)2.74599548
27Aplasia/Hypoplasia of the patella (HP:0006498)2.72849928
28Female pseudohermaphroditism (HP:0010458)2.67821604
29Long nose (HP:0003189)2.63928692
30Decreased central vision (HP:0007663)2.63668520
31Lissencephaly (HP:0001339)2.58746020
32Increased IgE level (HP:0003212)2.56784045
33Chronic sinusitis (HP:0011109)2.54904879
34Pendular nystagmus (HP:0012043)2.54457717
35Breech presentation (HP:0001623)2.53785846
36Fair hair (HP:0002286)2.52659494
37Polymicrogyria (HP:0002126)2.50912395
38Partial duplication of the phalanx of hand (HP:0009999)2.50140741
39Abnormality of the ischium (HP:0003174)2.47490166
40Retinal atrophy (HP:0001105)2.46928053
41Posterior embryotoxon (HP:0000627)2.46770888
42Congenital, generalized hypertrichosis (HP:0004540)2.44519722
43Cerebellar dysplasia (HP:0007033)2.42874316
44Prominent supraorbital ridges (HP:0000336)2.38596359
45Abnormality of the line of Schwalbe (HP:0008048)2.33113551
46Furrowed tongue (HP:0000221)2.26515549
47Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.25597930
48Retinal dysplasia (HP:0007973)2.24655286
49Aplasia involving bones of the extremities (HP:0009825)2.20991609
50Aplasia involving bones of the upper limbs (HP:0009823)2.20991609
51Aplasia of the phalanges of the hand (HP:0009802)2.20991609
52Genetic anticipation (HP:0003743)2.16409824
53Clitoromegaly (HP:0000057)2.11831491
54Ovoid vertebral bodies (HP:0003300)2.11224698
55Broad-based gait (HP:0002136)2.06915108
56Abnormality of the parietal bone (HP:0002696)2.06852769
57Depressed nasal tip (HP:0000437)2.06779010
58Molar tooth sign on MRI (HP:0002419)2.05580517
59Abnormality of midbrain morphology (HP:0002418)2.05580517
60Metabolic alkalosis (HP:0200114)2.02529839
61Generalized hypopigmentation of hair (HP:0011358)2.01960544
62Hypoplasia of the capital femoral epiphysis (HP:0003090)2.01202984
63Hyperglycinuria (HP:0003108)2.01104732
64Visual hallucinations (HP:0002367)2.00927696
65Thoracic kyphosis (HP:0002942)2.00761627
66Absent/shortened dynein arms (HP:0200106)1.99775731
67Dynein arm defect of respiratory motile cilia (HP:0012255)1.99775731
68Thyroid-stimulating hormone excess (HP:0002925)1.98442874
69Intellectual disability, severe (HP:0010864)1.98057948
70Hyperaldosteronism (HP:0000859)1.95176278
71Optic disc pallor (HP:0000543)1.94647858
72Epiphyseal stippling (HP:0010655)1.92659254
73Broad toe (HP:0001837)1.91916805
74Widely patent fontanelles and sutures (HP:0004492)1.89611686
75Abnormality of the sella turcica (HP:0002679)1.88834549
76Pancreatic fibrosis (HP:0100732)1.88492469
77True hermaphroditism (HP:0010459)1.88356991
78Broad hallux (HP:0010055)1.88177957
79Recurrent corneal erosions (HP:0000495)1.84652529
80Tubulointerstitial abnormality (HP:0001969)1.81146624
81Coronal craniosynostosis (HP:0004440)1.80799992
82Morphological abnormality of the pyramidal tract (HP:0002062)1.80661382
83Adrenal hypoplasia (HP:0000835)1.79022029
84Hyperalaninemia (HP:0003348)1.79007330
85Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79007330
86Abnormality of alanine metabolism (HP:0010916)1.79007330
87Absent septum pellucidum (HP:0001331)1.76237609
88Abnormality of renin-angiotensin system (HP:0000847)1.76124445
89Underdeveloped supraorbital ridges (HP:0009891)1.75906923
90Decreased circulating renin level (HP:0003351)1.75759147
91Aplasia/Hypoplasia of the hallux (HP:0008362)1.75401982
92Prolonged QT interval (HP:0001657)1.74967374
93Short hallux (HP:0010109)1.73935194
94Drooling (HP:0002307)1.72620092
95Tented upper lip vermilion (HP:0010804)1.71727197
96Abnormality of proline metabolism (HP:0010907)1.71300097
97Hydroxyprolinuria (HP:0003080)1.71300097
98Hyperkalemia (HP:0002153)1.69817345
99Acute encephalopathy (HP:0006846)1.68175428
100Abnormality of the septum pellucidum (HP:0007375)1.64838875

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR23.12735606
2NEK92.92528847
3MUSK2.87146018
4NTRK12.40372809
5INSRR12.2073208
6TRIB31.84177444
7MET1.84079587
8CLK11.77029125
9BRSK21.73829639
10DAPK21.72015475
11LATS11.63116699
12PNCK1.62747524
13MAPK131.48882359
14ADRBK11.43664802
15NTRK21.38931154
16MAP3K21.37596699
17ERBB31.31005830
18MAP2K21.20185149
19FGR1.10798596
20PTK2B1.05511855
21STK381.05379704
22PIK3CA1.02574286
23CAMK1D1.01102714
24ADRBK20.97714475
25STK38L0.97184773
26RET0.96376168
27EPHB10.95387686
28PDGFRB0.91557431
29OXSR10.91505831
30MAPK150.89951577
31STK390.89704969
32TLK10.87684607
33FRK0.85702645
34BMX0.85640165
35IRAK40.85493657
36WNK40.83971320
37CAMKK10.82022871
38IRAK20.80118141
39VRK20.80108023
40TAOK30.79630737
41MAP3K110.77915361
42WEE10.73061229
43NUAK10.72236104
44GRK50.71779549
45TNK20.70609783
46CSF1R0.69866086
47PINK10.69609824
48ERBB20.69010028
49BMPR1B0.66637978
50MAPK110.66129959
51ACVR1B0.66019643
52GRK10.64660491
53TGFBR10.63096665
54MKNK20.62949876
55MARK10.61159872
56CAMKK20.61111886
57CCNB10.58958623
58PLK40.58586509
59ICK0.58127735
60VRK10.56880020
61BRSK10.56701884
62KSR20.54791325
63CASK0.54529160
64MAP3K100.52893038
65HIPK20.52007107
66WNK30.51779648
67RPS6KA60.51052201
68RPS6KA50.47137408
69CAMK1G0.45258648
70TSSK60.44562888
71LATS20.43928500
72PTK60.40786204
73IGF1R0.39255755
74STK110.36199229
75MAP3K120.35637549
76MAP2K10.35126335
77PRKAA20.31992876
78NLK0.30974063
79ILK0.27509230
80DYRK1A0.26336027
81CAMK2A0.26031775
82MAPKAPK50.25948024
83GRK60.24623286
84PRKCG0.24483163
85RIPK40.22852370
86PBK0.21369618
87PRKACA0.20917696
88BRAF0.20806927
89FLT30.19760131
90MKNK10.19137884
91ZAP700.18348041
92MELK0.17904323
93PASK0.17869267
94EPHA40.17798176
95LCK0.15815011
96PRKACG0.14572301
97CAMK40.14490092
98PRKCE0.14307027
99PLK10.12158298
100ROCK10.11896058

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006018.36453869
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000534.94374527
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.05709119
4Sulfur relay system_Homo sapiens_hsa041222.75020490
5Linoleic acid metabolism_Homo sapiens_hsa005912.71825278
6Steroid hormone biosynthesis_Homo sapiens_hsa001402.23502857
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.20433752
8Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.09620819
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.00243412
10Ether lipid metabolism_Homo sapiens_hsa005651.92163915
11Phototransduction_Homo sapiens_hsa047441.89828149
12Butanoate metabolism_Homo sapiens_hsa006501.85497894
13Drug metabolism - other enzymes_Homo sapiens_hsa009831.76964490
14Ribosome_Homo sapiens_hsa030101.74118852
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.64150730
16Retinol metabolism_Homo sapiens_hsa008301.61328774
17Peroxisome_Homo sapiens_hsa041461.54933159
18Nicotine addiction_Homo sapiens_hsa050331.53339983
19Arachidonic acid metabolism_Homo sapiens_hsa005901.52026918
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.49440218
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.46758371
22Propanoate metabolism_Homo sapiens_hsa006401.36282026
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35618641
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.34411586
25Taste transduction_Homo sapiens_hsa047421.31574218
26Chemical carcinogenesis_Homo sapiens_hsa052041.27254587
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.18835677
28Ovarian steroidogenesis_Homo sapiens_hsa049131.18809117
29Steroid biosynthesis_Homo sapiens_hsa001001.11605126
30Starch and sucrose metabolism_Homo sapiens_hsa005001.07204053
31Bile secretion_Homo sapiens_hsa049761.05171121
32VEGF signaling pathway_Homo sapiens_hsa043701.04793054
33Cholinergic synapse_Homo sapiens_hsa047250.87908587
34Long-term depression_Homo sapiens_hsa047300.87580267
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86560262
36Type II diabetes mellitus_Homo sapiens_hsa049300.84485316
37Maturity onset diabetes of the young_Homo sapiens_hsa049500.83882554
38RNA degradation_Homo sapiens_hsa030180.82715972
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76851463
40Glutamatergic synapse_Homo sapiens_hsa047240.75779904
41Glycosaminoglycan degradation_Homo sapiens_hsa005310.74999893
42mRNA surveillance pathway_Homo sapiens_hsa030150.73890177
43Cyanoamino acid metabolism_Homo sapiens_hsa004600.73033033
44Vitamin digestion and absorption_Homo sapiens_hsa049770.70969881
45Morphine addiction_Homo sapiens_hsa050320.68571430
46Amphetamine addiction_Homo sapiens_hsa050310.63498446
47Fatty acid biosynthesis_Homo sapiens_hsa000610.62254975
48Serotonergic synapse_Homo sapiens_hsa047260.61424365
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60945595
50Glycerophospholipid metabolism_Homo sapiens_hsa005640.60834633
51Insulin secretion_Homo sapiens_hsa049110.58903732
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58444107
53Circadian entrainment_Homo sapiens_hsa047130.55020406
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.55007069
55Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53746285
56Selenocompound metabolism_Homo sapiens_hsa004500.51949976
57Oxytocin signaling pathway_Homo sapiens_hsa049210.51896541
58Estrogen signaling pathway_Homo sapiens_hsa049150.51078520
59Cocaine addiction_Homo sapiens_hsa050300.50698632
60Basal cell carcinoma_Homo sapiens_hsa052170.50391065
61Calcium signaling pathway_Homo sapiens_hsa040200.49762705
62Gastric acid secretion_Homo sapiens_hsa049710.46672973
63Prostate cancer_Homo sapiens_hsa052150.45444010
64Oxidative phosphorylation_Homo sapiens_hsa001900.44237109
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41081310
66Glucagon signaling pathway_Homo sapiens_hsa049220.40821853
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40321752
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38065307
69Parkinsons disease_Homo sapiens_hsa050120.37535735
70GABAergic synapse_Homo sapiens_hsa047270.35170851
71Tryptophan metabolism_Homo sapiens_hsa003800.35035313
72Alzheimers disease_Homo sapiens_hsa050100.34825734
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.34772466
74Wnt signaling pathway_Homo sapiens_hsa043100.34769355
75Dopaminergic synapse_Homo sapiens_hsa047280.33749440
76TNF signaling pathway_Homo sapiens_hsa046680.33714832
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32876416
78Melanoma_Homo sapiens_hsa052180.32673531
79Circadian rhythm_Homo sapiens_hsa047100.31529778
80Axon guidance_Homo sapiens_hsa043600.30183999
81Histidine metabolism_Homo sapiens_hsa003400.30034814
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29836519
83cAMP signaling pathway_Homo sapiens_hsa040240.29633745
84Dorso-ventral axis formation_Homo sapiens_hsa043200.29017182
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28023794
86Olfactory transduction_Homo sapiens_hsa047400.27594247
87Bladder cancer_Homo sapiens_hsa052190.27574518
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27364322
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27087897
90TGF-beta signaling pathway_Homo sapiens_hsa043500.25611072
91Choline metabolism in cancer_Homo sapiens_hsa052310.24052060
92Metabolic pathways_Homo sapiens_hsa011000.23623148
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22669878
94Arginine and proline metabolism_Homo sapiens_hsa003300.22508880
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.21935250
96Regulation of autophagy_Homo sapiens_hsa041400.21161285
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.20654092
98Melanogenesis_Homo sapiens_hsa049160.20031618
99Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.19145105
100Cardiac muscle contraction_Homo sapiens_hsa042600.18698692

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