SOCS5P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)5.31328684
2DNA topological change (GO:0006265)5.21379610
3purine nucleobase biosynthetic process (GO:0009113)5.04332410
4mitotic sister chromatid cohesion (GO:0007064)4.74773297
5nucleobase biosynthetic process (GO:0046112)4.55283585
6meiotic chromosome segregation (GO:0045132)3.91899905
7regulation of histone H3-K27 methylation (GO:0061085)3.86045498
8nuclear pore complex assembly (GO:0051292)3.74839244
9DNA strand renaturation (GO:0000733)3.72123780
10IMP biosynthetic process (GO:0006188)3.65398681
11negative regulation of DNA repair (GO:0045738)3.60561543
12positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.32661581
13cellular response to fluid shear stress (GO:0071498)3.29511108
14DNA ligation (GO:0006266)3.25044091
15heterochromatin organization (GO:0070828)3.24065849
16anterior/posterior axis specification, embryo (GO:0008595)3.23259849
17viral transcription (GO:0019083)3.20551499
18positive regulation of cell cycle checkpoint (GO:1901978)3.16764556
19SMAD protein complex assembly (GO:0007183)3.16583175
20extracellular matrix assembly (GO:0085029)3.10568622
21IMP metabolic process (GO:0046040)3.03321611
22translational termination (GO:0006415)2.97935918
23response to peptidoglycan (GO:0032494)2.95436649
24renal absorption (GO:0070293)2.94941730
25positive regulation of protein import into nucleus, translocation (GO:0033160)2.94060231
26regulation of energy homeostasis (GO:2000505)2.93625313
27positive regulation of interferon-alpha production (GO:0032727)2.92408674
28positive regulation of DNA-dependent DNA replication (GO:2000105)2.91267503
29mitotic G2/M transition checkpoint (GO:0044818)2.88981091
30L-serine metabolic process (GO:0006563)2.88170998
31DNA geometric change (GO:0032392)2.82874096
32nuclear pore organization (GO:0006999)2.79247859
33cellular response to epidermal growth factor stimulus (GO:0071364)2.78877296
34G1 DNA damage checkpoint (GO:0044783)2.77718005
35positive regulation of actin cytoskeleton reorganization (GO:2000251)2.76458098
36DNA duplex unwinding (GO:0032508)2.75742975
37RNA stabilization (GO:0043489)2.74920289
38mRNA stabilization (GO:0048255)2.74920289
39histone-serine phosphorylation (GO:0035404)2.72464838
40antigen processing and presentation via MHC class Ib (GO:0002475)2.70130009
41ribosomal small subunit biogenesis (GO:0042274)2.70097470
42formation of translation preinitiation complex (GO:0001731)2.69894353
43positive regulation of keratinocyte differentiation (GO:0045618)2.69763610
44spindle assembly involved in mitosis (GO:0090307)2.66906896
45regulation of interferon-alpha production (GO:0032647)2.65652511
46regulation of helicase activity (GO:0051095)2.65313502
47DNA replication checkpoint (GO:0000076)2.64072151
48positive regulation of gamma-delta T cell activation (GO:0046645)2.63540364
49regulation of DNA damage checkpoint (GO:2000001)2.63012932
50DNA unwinding involved in DNA replication (GO:0006268)2.60805590
51positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.59545286
52nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.58591923
53histone phosphorylation (GO:0016572)2.57904209
54mitotic G2 DNA damage checkpoint (GO:0007095)2.55612735
55G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.54215179
56histone H4-K16 acetylation (GO:0043984)2.52811907
57maturation of SSU-rRNA (GO:0030490)2.52001932
58positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.51207391
59glycoprotein catabolic process (GO:0006516)2.49918442
60pore complex assembly (GO:0046931)2.49430765
61endosome to melanosome transport (GO:0035646)2.47665076
62endosome to pigment granule transport (GO:0043485)2.47665076
63mammary gland epithelial cell proliferation (GO:0033598)2.46173291
64regulation of double-strand break repair (GO:2000779)2.45641745
65DNA replication initiation (GO:0006270)2.45549937
66intracellular lipid transport (GO:0032365)2.45423941
67translational initiation (GO:0006413)2.43401781
68protein localization to chromosome, centromeric region (GO:0071459)2.43146351
69detection of molecule of bacterial origin (GO:0032490)2.42075800
70carnitine shuttle (GO:0006853)2.37446338
71translational elongation (GO:0006414)2.36866612
72protein hydroxylation (GO:0018126)2.36678096
73histone deubiquitination (GO:0016578)2.36520461
74osteoclast differentiation (GO:0030316)2.35194589
75monoubiquitinated protein deubiquitination (GO:0035520)2.34882770
76regulation of thymocyte apoptotic process (GO:0070243)2.34640447
77T cell lineage commitment (GO:0002360)2.32825595
78DNA conformation change (GO:0071103)2.32680656
79response to muramyl dipeptide (GO:0032495)2.31575414
80pinocytosis (GO:0006907)2.31276662
81cellular response to exogenous dsRNA (GO:0071360)2.31115389
82SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.28668836
83positive regulation of odontogenesis (GO:0042482)2.28461983
84mitotic G1 DNA damage checkpoint (GO:0031571)2.26776747
85kinetochore organization (GO:0051383)2.25855644
86mannose metabolic process (GO:0006013)2.25374893
87cellular protein complex disassembly (GO:0043624)2.25276840
88microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.24465767
89viral life cycle (GO:0019058)2.24416611
90ribosomal small subunit assembly (GO:0000028)2.24400627
91negative regulation of gluconeogenesis (GO:0045721)2.24291931
92hyaluronan metabolic process (GO:0030212)2.23990342
93sister chromatid segregation (GO:0000819)2.23765141
94regulation of coenzyme metabolic process (GO:0051196)2.23030122
95regulation of cofactor metabolic process (GO:0051193)2.23030122
96mitotic sister chromatid segregation (GO:0000070)2.22964078
97V(D)J recombination (GO:0033151)2.22723309
98mitotic G1/S transition checkpoint (GO:0044819)2.22259946
99response to epidermal growth factor (GO:0070849)2.22164936
100oligosaccharide catabolic process (GO:0009313)2.22092233

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.17537907
2STAT6_21828071_ChIP-Seq_BEAS2B_Human6.05384881
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.24689223
4E2F4_17652178_ChIP-ChIP_JURKAT_Human2.97918635
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.81350054
6MYC_22102868_ChIP-Seq_BL_Human2.81242248
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.53532847
8VDR_21846776_ChIP-Seq_THP-1_Human2.47220999
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.37454801
10AR_21909140_ChIP-Seq_LNCAP_Human2.33980117
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.16055356
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.13380282
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.03236902
14KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.00295627
15TFEB_21752829_ChIP-Seq_HELA_Human1.95255500
16GATA1_22025678_ChIP-Seq_K562_Human1.93418578
17TP63_19390658_ChIP-ChIP_HaCaT_Human1.84821637
18E2F1_21310950_ChIP-Seq_MCF-7_Human1.68043559
19ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.61311416
20MYC_19030024_ChIP-ChIP_MESCs_Mouse1.59201741
21TCF7_22412390_ChIP-Seq_EML_Mouse1.58259048
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.54832204
23XRN2_22483619_ChIP-Seq_HELA_Human1.52931957
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.48200309
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45957906
26MYB_21317192_ChIP-Seq_ERMYB_Mouse1.45222181
27RBPJ_22232070_ChIP-Seq_NCS_Mouse1.44556181
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42534984
29MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.41407107
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.41199265
31DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.40821099
32SPI1_23547873_ChIP-Seq_NB4_Human1.40747320
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.40400012
34VDR_24763502_ChIP-Seq_THP-1_Human1.39678016
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37606158
36SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33955405
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.33304235
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.33102495
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.33085291
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.30712414
41MAF_26560356_Chip-Seq_TH1_Human1.29674788
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.29045874
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.28411207
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.28173427
45CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27208320
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.26314452
47SALL4_18804426_ChIP-ChIP_XEN_Mouse1.25639045
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25342705
49NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.23974763
50UTX_26944678_Chip-Seq_JUKART_Human1.23015551
51MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20657075
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19107797
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.18766086
54IRF8_21731497_ChIP-ChIP_J774_Mouse1.17736857
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17697161
56IRF8_27001747_Chip-Seq_BMDM_Mouse1.17553461
57MAF_26560356_Chip-Seq_TH2_Human1.17052546
58CIITA_25753668_ChIP-Seq_RAJI_Human1.16865913
59ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16148085
60STAT4_19710469_ChIP-ChIP_TH1__Mouse1.16071313
61KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11780281
62NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10780411
63PU_27001747_Chip-Seq_BMDM_Mouse1.09828654
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09188329
65CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08722499
66UBF1/2_26484160_Chip-Seq_HMECs_Human1.07421428
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07152865
68FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.07075025
69KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06444367
70CHD1_26751641_Chip-Seq_LNCaP_Human1.05301614
71DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04759726
72YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04308441
73KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02609650
74ATF3_27146783_Chip-Seq_COLON_Human1.02225605
75KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02132123
76RUNX_20019798_ChIP-Seq_JUKART_Human1.02122431
77MYB_26560356_Chip-Seq_TH1_Human1.02060020
78PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01991368
79KDM5A_27292631_Chip-Seq_BREAST_Human1.01881570
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99435339
81HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96521218
82CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95953935
83CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95840468
84TTF2_22483619_ChIP-Seq_HELA_Human0.94862697
85ELK3_25401928_ChIP-Seq_HUVEC_Human0.94315324
86ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94136957
87KDM2B_26808549_Chip-Seq_DND41_Human0.93559925
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93340044
89KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92837980
90SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.92400236
91HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.92377540
92STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.92187433
93NCOR1_26117541_ChIP-Seq_K562_Human0.92138195
94RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.90452387
95CREB1_15753290_ChIP-ChIP_HEK293T_Human0.89554978
96SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.88881269
97SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.88881269
98MYB_26560356_Chip-Seq_TH2_Human0.87999896
99NANOG_18555785_ChIP-Seq_MESCs_Mouse0.87636832
100E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.86496347

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.25782343
2MP0008057_abnormal_DNA_replication4.27463212
3MP0005174_abnormal_tail_pigmentation3.28997566
4MP0000015_abnormal_ear_pigmentation2.69919317
5MP0003172_abnormal_lysosome_physiology2.60949534
6MP0010094_abnormal_chromosome_stability2.28365557
7MP0003705_abnormal_hypodermis_morpholog2.25933084
8MP0010307_abnormal_tumor_latency2.17035668
9MP0005451_abnormal_body_composition2.16511857
10MP0003111_abnormal_nucleus_morphology2.15828770
11MP0003828_pulmonary_edema2.14211608
12MP0005409_darkened_coat_color2.00644312
13MP0005076_abnormal_cell_differentiation1.80791608
14MP0003077_abnormal_cell_cycle1.66489167
15MP0004957_abnormal_blastocyst_morpholog1.65791664
16MP0004381_abnormal_hair_follicle1.62543163
17MP0000383_abnormal_hair_follicle1.61249999
18MP0003091_abnormal_cell_migration1.59618757
19MP0001348_abnormal_lacrimal_gland1.53379155
20MP0000371_diluted_coat_color1.51519775
21MP0003890_abnormal_embryonic-extraembry1.51389367
22MP0003566_abnormal_cell_adhesion1.49486718
23MP0005058_abnormal_lysosome_morphology1.47814413
24MP0002396_abnormal_hematopoietic_system1.43640402
25MP0002998_abnormal_bone_remodeling1.42595723
26MP0003453_abnormal_keratinocyte_physiol1.40849828
27MP0004197_abnormal_fetal_growth/weight/1.39776981
28MP0002086_abnormal_extraembryonic_tissu1.28408182
29MP0008007_abnormal_cellular_replicative1.28099524
30MP0001697_abnormal_embryo_size1.24538257
31MP0008058_abnormal_DNA_repair1.24317204
32MP0003984_embryonic_growth_retardation1.23828105
33MP0000350_abnormal_cell_proliferation1.23627278
34MP0001672_abnormal_embryogenesis/_devel1.19652195
35MP0005380_embryogenesis_phenotype1.19652195
36MP0002088_abnormal_embryonic_growth/wei1.19000503
37MP0010678_abnormal_skin_adnexa1.18625344
38MP0004808_abnormal_hematopoietic_stem1.17194538
39MP0005257_abnormal_intraocular_pressure1.16480991
40MP0002132_abnormal_respiratory_system1.16268793
41MP0002075_abnormal_coat/hair_pigmentati1.14148834
42MP0001293_anophthalmia1.14024871
43MP0002405_respiratory_system_inflammati1.12242173
44MP0005075_abnormal_melanosome_morpholog1.10623509
45MP0000767_abnormal_smooth_muscle1.10264687
46MP0003195_calcinosis1.09649317
47MP0003937_abnormal_limbs/digits/tail_de1.09322569
48MP0001835_abnormal_antigen_presentation1.09292106
49MP0004185_abnormal_adipocyte_glucose1.08919089
50MP0005197_abnormal_uvea_morphology1.06655494
51MP0002092_abnormal_eye_morphology1.06306780
52MP0002419_abnormal_innate_immunity1.04157144
53MP0006082_CNS_inflammation1.02911107
54MP0002019_abnormal_tumor_incidence1.00965430
55MP0004264_abnormal_extraembryonic_tissu0.99289354
56MP0003693_abnormal_embryo_hatching0.98672089
57MP0000858_altered_metastatic_potential0.98238102
58MP0004947_skin_inflammation0.96025935
59MP0003136_yellow_coat_color0.95938054
60MP0000428_abnormal_craniofacial_morphol0.95771213
61MP0001730_embryonic_growth_arrest0.95527246
62MP0003303_peritoneal_inflammation0.95475567
63MP0005464_abnormal_platelet_physiology0.91657623
64MP0002080_prenatal_lethality0.88786830
65MP0002452_abnormal_antigen_presenting0.88568891
66MP0002398_abnormal_bone_marrow0.88117578
67MP0001186_pigmentation_phenotype0.87450183
68MP0000313_abnormal_cell_death0.86262857
69MP0002877_abnormal_melanocyte_morpholog0.86096538
70MP0000685_abnormal_immune_system0.85971238
71MP0001286_abnormal_eye_development0.85851101
72MP0002932_abnormal_joint_morphology0.85617524
73MP0001800_abnormal_humoral_immune0.85065709
74MP0002084_abnormal_developmental_patter0.84272335
75MP0009840_abnormal_foam_cell0.82896159
76MP0005000_abnormal_immune_tolerance0.82180206
77MP0000490_abnormal_crypts_of0.81181105
78MP0003448_altered_tumor_morphology0.81036010
79MP0005023_abnormal_wound_healing0.79977498
80MP0002723_abnormal_immune_serum0.79579646
81MP0000689_abnormal_spleen_morphology0.78728956
82MP0005387_immune_system_phenotype0.78649509
83MP0001790_abnormal_immune_system0.78649509
84MP0009672_abnormal_birth_weight0.77947677
85MP0003115_abnormal_respiratory_system0.76753562
86MP0001819_abnormal_immune_cell0.76635627
87MP0002420_abnormal_adaptive_immunity0.76516002
88MP0002009_preneoplasia0.76053185
89MP0002111_abnormal_tail_morphology0.75929438
90MP0002697_abnormal_eye_size0.75652805
91MP0010030_abnormal_orbit_morphology0.74753127
92MP0003300_gastrointestinal_ulcer0.74297947
93MP0003221_abnormal_cardiomyocyte_apopto0.74239526
94MP0002429_abnormal_blood_cell0.73847962
95MP0003763_abnormal_thymus_physiology0.73733874
96MP0002254_reproductive_system_inflammat0.73455978
97MP0005621_abnormal_cell_physiology0.72932612
98MP0001915_intracranial_hemorrhage0.72872011
99MP0008438_abnormal_cutaneous_collagen0.71715255
100MP0003943_abnormal_hepatobiliary_system0.71457123

Predicted human phenotypes

RankGene SetZ-score
1Malnutrition (HP:0004395)4.85467559
2Intestinal fistula (HP:0100819)4.01663089
3Aplasia/Hypoplasia of the sacrum (HP:0008517)4.01266270
4Rectal fistula (HP:0100590)3.90953709
5Rectovaginal fistula (HP:0000143)3.90953709
6Short humerus (HP:0005792)3.75772763
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.54073630
8Vaginal fistula (HP:0004320)3.53726467
9Absent radius (HP:0003974)3.49600118
10Aplasia/hypoplasia of the humerus (HP:0006507)3.45135715
11Aplasia involving forearm bones (HP:0009822)3.20222283
12Absent forearm bone (HP:0003953)3.20222283
13Duplicated collecting system (HP:0000081)3.11116473
14Short middle phalanx of the 5th finger (HP:0004220)2.97804639
15Reticulocytopenia (HP:0001896)2.96211507
16Chromsome breakage (HP:0040012)2.96168087
17Anteriorly placed anus (HP:0001545)2.93262935
18Long eyelashes (HP:0000527)2.88635730
19Facial hemangioma (HP:0000329)2.85669027
20Abnormal umbilical cord blood vessels (HP:0011403)2.85648857
21Single umbilical artery (HP:0001195)2.85648857
22Abnormality of the fetal cardiovascular system (HP:0010948)2.85648857
23Birth length less than 3rd percentile (HP:0003561)2.84051926
24Poikiloderma (HP:0001029)2.82911922
25Urethral obstruction (HP:0000796)2.79970485
26Ureteral duplication (HP:0000073)2.76473253
27Abnormality of chromosome stability (HP:0003220)2.72071292
28Anal stenosis (HP:0002025)2.70640830
29Aplasia/Hypoplasia of the uvula (HP:0010293)2.69509401
30Progressive external ophthalmoplegia (HP:0000590)2.57278312
31Squamous cell carcinoma (HP:0002860)2.56789814
32Myelodysplasia (HP:0002863)2.56013839
33Abnormality of the distal phalanges of the toes (HP:0010182)2.53313351
34Increased number of teeth (HP:0011069)2.52997516
35Broad face (HP:0000283)2.43112205
36Meckel diverticulum (HP:0002245)2.38240551
37Abnormality of the preputium (HP:0100587)2.35084262
38Abnormality of the renal collecting system (HP:0004742)2.33247670
39Absent thumb (HP:0009777)2.29751562
40Dislocated radial head (HP:0003083)2.25503523
41Leiomyosarcoma (HP:0100243)2.24620516
42Uterine leiomyosarcoma (HP:0002891)2.24620516
43Abnormality of the ileum (HP:0001549)2.24122958
44Abnormality of the salivary glands (HP:0010286)2.23588170
45Clubbing of toes (HP:0100760)2.22518608
46Abnormality of the right ventricle (HP:0001707)2.21997977
47Missing ribs (HP:0000921)2.21281816
48Abnormality of oral frenula (HP:0000190)2.19345476
49Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.16120998
50Bifid tongue (HP:0010297)2.15608656
51Curly hair (HP:0002212)2.14517235
52Acute lymphatic leukemia (HP:0006721)2.14165052
53Syringomyelia (HP:0003396)2.11572055
54Spinal cord lesions (HP:0100561)2.11572055
55Abnormality of the umbilical cord (HP:0010881)2.11108778
56Abnormality of the labia majora (HP:0012881)2.10878875
57Inflammation of the large intestine (HP:0002037)2.09899988
58Deviation of the thumb (HP:0009603)2.06151202
59Long palpebral fissure (HP:0000637)2.04617975
60Abnormality of the radial head (HP:0003995)1.99214259
61Abnormality of DNA repair (HP:0003254)1.98623960
62Abnormality of cells of the erythroid lineage (HP:0012130)1.98071278
63Transitional cell carcinoma of the bladder (HP:0006740)1.97163482
64Myocardial infarction (HP:0001658)1.96783881
65Hypoplastic labia majora (HP:0000059)1.96173005
66Proximal placement of thumb (HP:0009623)1.95547493
67Abnormality of the intrinsic pathway (HP:0010989)1.95304136
68Trigonocephaly (HP:0000243)1.95024115
69Gastrointestinal inflammation (HP:0004386)1.94381410
70Short 5th finger (HP:0009237)1.93990579
71Hypoplastic pelvis (HP:0008839)1.93776497
72Short 1st metacarpal (HP:0010034)1.93439657
73Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.93439657
74Stenosis of the external auditory canal (HP:0000402)1.91108600
75Ulnar bowing (HP:0003031)1.88869235
76Nasolacrimal duct obstruction (HP:0000579)1.87987213
77Asymmetry of the thorax (HP:0001555)1.86147883
78Subacute progressive viral hepatitis (HP:0006572)1.85892578
79Duplication of thumb phalanx (HP:0009942)1.85077828
80Duodenal stenosis (HP:0100867)1.84016803
81Small intestinal stenosis (HP:0012848)1.84016803
82Malignant gastrointestinal tract tumors (HP:0006749)1.83503887
83Gastrointestinal carcinoma (HP:0002672)1.83503887
84Mesomelia (HP:0003027)1.82666719
85Bone marrow hypocellularity (HP:0005528)1.80781993
86Bladder carcinoma (HP:0002862)1.78612456
87Bladder neoplasm (HP:0009725)1.78612456
88Thoracolumbar scoliosis (HP:0002944)1.77218703
89Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.76809075
90Arteriovenous malformation (HP:0100026)1.76764854
91Ankyloglossia (HP:0010296)1.74125708
92Choroideremia (HP:0001139)1.73679520
93Entropion (HP:0000621)1.73291187
94Abnormal number of erythroid precursors (HP:0012131)1.73022040
95Thin bony cortex (HP:0002753)1.72975218
96Viral hepatitis (HP:0006562)1.72519341
97Abnormality of the 1st metacarpal (HP:0010009)1.68480007
98Breast hypoplasia (HP:0003187)1.68430680
99Recurrent viral infections (HP:0004429)1.67772235
100Steatorrhea (HP:0002570)1.64841244

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B4.09551626
2BRD43.16814490
3MAP3K103.08203016
4TGFBR13.05708840
5TAOK32.74499158
6BMPR1B2.64376103
7CDK122.56992129
8ICK2.39689365
9TTK2.27377677
10PKN22.14859217
11SMG11.96277777
12TAF11.94305269
13NME21.90472248
14CDK41.73815636
15MELK1.72782506
16LATS11.71755320
17MKNK11.63303717
18MAP3K41.55012798
19MAP2K31.54965300
20TRIB31.44794072
21WNK31.41312854
22PLK41.41230251
23PASK1.38905207
24EPHA21.34763829
25PRKAA21.29996684
26MAP3K61.28360834
27LRRK21.26013438
28BRAF1.24117600
29FLT31.23354875
30IRAK31.22986581
31EIF2AK31.20400730
32MST1R1.18546649
33CHEK21.15375491
34CDK81.14087252
35STK101.11727270
36TTN1.11447435
37CDC71.10055108
38PRPF4B1.07864492
39CDK61.07775306
40BLK1.07117101
41MAP3K141.02576787
42CDK191.00059591
43MKNK20.97464298
44ATR0.96995394
45BUB10.95445493
46ERN10.92060038
47WNK10.92054231
48SGK30.89425768
49NEK90.88948707
50EIF2AK10.87323957
51FGFR40.86531874
52MAP3K30.86228269
53LATS20.83226375
54RIPK40.82645683
55IRAK40.82368867
56ZAP700.79827604
57KSR20.77077943
58FGFR10.76889380
59CDK70.75505857
60SGK20.73053335
61ZAK0.72445421
62FGR0.70036417
63NUAK10.68260102
64PDGFRA0.67168630
65MET0.66756339
66RIPK10.62434519
67CSK0.61697025
68RAF10.61617008
69MAP3K130.61453508
70VRK20.60861568
71IKBKE0.59503117
72MAP3K70.57804458
73MARK20.57398843
74TYK20.55470634
75CHEK10.55257467
76CDK90.54353378
77AKT30.53985270
78MTOR0.52001363
79PTK60.51672786
80HIPK20.51216608
81TGFBR20.50571047
82GRK60.48632033
83NEK20.48538065
84CDC42BPA0.47338541
85JAK30.44824459
86MATK0.44657280
87MAP4K10.44283112
88SIK10.44215643
89AURKB0.43597018
90IRAK20.43398797
91INSRR0.40745911
92FGFR30.40325143
93CDK30.39659133
94KSR10.38627397
95CAMK1D0.38043145
96CDK20.36733491
97MAP3K80.36676489
98STK40.35937522
99TSSK60.35881407
100YES10.35757563

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004602.63724915
2Other glycan degradation_Homo sapiens_hsa005112.33183321
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.26455468
4Bladder cancer_Homo sapiens_hsa052192.17935516
5Mismatch repair_Homo sapiens_hsa034302.10484240
6Cell cycle_Homo sapiens_hsa041101.98844045
7DNA replication_Homo sapiens_hsa030301.81950705
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.78656327
9Glycosaminoglycan degradation_Homo sapiens_hsa005311.72305185
10Fanconi anemia pathway_Homo sapiens_hsa034601.67295295
11Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.61272546
12Non-small cell lung cancer_Homo sapiens_hsa052231.59252527
13Non-homologous end-joining_Homo sapiens_hsa034501.55095898
14Pancreatic cancer_Homo sapiens_hsa052121.51201881
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.50635307
16Thyroid cancer_Homo sapiens_hsa052161.50095189
17Chronic myeloid leukemia_Homo sapiens_hsa052201.50087439
18Fructose and mannose metabolism_Homo sapiens_hsa000511.42435929
19Central carbon metabolism in cancer_Homo sapiens_hsa052301.41192241
20Ribosome_Homo sapiens_hsa030101.39804509
21MicroRNAs in cancer_Homo sapiens_hsa052061.36483898
22Acute myeloid leukemia_Homo sapiens_hsa052211.34627214
23Hedgehog signaling pathway_Homo sapiens_hsa043401.34608533
24Adherens junction_Homo sapiens_hsa045201.33272207
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.30312238
26Nucleotide excision repair_Homo sapiens_hsa034201.27668759
27mRNA surveillance pathway_Homo sapiens_hsa030151.26980642
28GnRH signaling pathway_Homo sapiens_hsa049121.25167852
29Hepatitis B_Homo sapiens_hsa051611.24873085
30Renal cell carcinoma_Homo sapiens_hsa052111.24179387
31Osteoclast differentiation_Homo sapiens_hsa043801.23400651
32Homologous recombination_Homo sapiens_hsa034401.22725378
33Choline metabolism in cancer_Homo sapiens_hsa052311.21060945
34Spliceosome_Homo sapiens_hsa030401.21048416
35Lysine degradation_Homo sapiens_hsa003101.20055366
36Toxoplasmosis_Homo sapiens_hsa051451.19581431
37Legionellosis_Homo sapiens_hsa051341.14304766
38Proteoglycans in cancer_Homo sapiens_hsa052051.12482570
39Glycerophospholipid metabolism_Homo sapiens_hsa005641.12274193
40B cell receptor signaling pathway_Homo sapiens_hsa046621.11608283
41NF-kappa B signaling pathway_Homo sapiens_hsa040641.10861586
42Base excision repair_Homo sapiens_hsa034101.10184372
43Small cell lung cancer_Homo sapiens_hsa052221.09713109
44Hepatitis C_Homo sapiens_hsa051601.09010974
45Prostate cancer_Homo sapiens_hsa052151.08125182
46Lysosome_Homo sapiens_hsa041421.07590113
47VEGF signaling pathway_Homo sapiens_hsa043701.07174606
48Notch signaling pathway_Homo sapiens_hsa043301.07130119
49Measles_Homo sapiens_hsa051621.06496330
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04249929
51Colorectal cancer_Homo sapiens_hsa052101.01621903
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.00887458
53p53 signaling pathway_Homo sapiens_hsa041150.97906999
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95032587
55NOD-like receptor signaling pathway_Homo sapiens_hsa046210.94530432
56HTLV-I infection_Homo sapiens_hsa051660.92931532
57RNA transport_Homo sapiens_hsa030130.90712895
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90505360
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.89478144
60Influenza A_Homo sapiens_hsa051640.87971960
61FoxO signaling pathway_Homo sapiens_hsa040680.87268049
62Ether lipid metabolism_Homo sapiens_hsa005650.87195320
63Toll-like receptor signaling pathway_Homo sapiens_hsa046200.85974501
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85556365
65Herpes simplex infection_Homo sapiens_hsa051680.84816387
66Apoptosis_Homo sapiens_hsa042100.84716105
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.82395457
68Ovarian steroidogenesis_Homo sapiens_hsa049130.81982142
69Inositol phosphate metabolism_Homo sapiens_hsa005620.80528211
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80100739
71TNF signaling pathway_Homo sapiens_hsa046680.77959628
72Tuberculosis_Homo sapiens_hsa051520.77877728
73Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.77483366
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76226071
75Viral carcinogenesis_Homo sapiens_hsa052030.74542416
76Prolactin signaling pathway_Homo sapiens_hsa049170.73856183
77mTOR signaling pathway_Homo sapiens_hsa041500.72601458
78Malaria_Homo sapiens_hsa051440.72503945
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72304539
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.71704572
81HIF-1 signaling pathway_Homo sapiens_hsa040660.71617812
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70878981
83Endometrial cancer_Homo sapiens_hsa052130.70832403
84Basal cell carcinoma_Homo sapiens_hsa052170.68910763
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64004852
86Leishmaniasis_Homo sapiens_hsa051400.63891881
87Long-term depression_Homo sapiens_hsa047300.63137158
88Pathways in cancer_Homo sapiens_hsa052000.60389551
89Hematopoietic cell lineage_Homo sapiens_hsa046400.60282012
90ErbB signaling pathway_Homo sapiens_hsa040120.59291605
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58888835
92Platelet activation_Homo sapiens_hsa046110.57112604
93Amoebiasis_Homo sapiens_hsa051460.55690387
94One carbon pool by folate_Homo sapiens_hsa006700.54916622
95TGF-beta signaling pathway_Homo sapiens_hsa043500.54896333
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53912056
97Primary immunodeficiency_Homo sapiens_hsa053400.53840910
98Circadian rhythm_Homo sapiens_hsa047100.52617349
99Insulin resistance_Homo sapiens_hsa049310.52299307
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50143227

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