SOCS6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1production of molecular mediator involved in inflammatory response (GO:0002532)4.75080550
2embryonic foregut morphogenesis (GO:0048617)3.79021819
3inner ear receptor cell development (GO:0060119)3.74077259
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.63412230
5desmosome organization (GO:0002934)3.44385971
6regulation of sister chromatid cohesion (GO:0007063)3.40873164
7wound healing, spreading of epidermal cells (GO:0035313)3.35714774
8nuclear pore organization (GO:0006999)3.35466806
9cytoplasmic mRNA processing body assembly (GO:0033962)3.34733791
10mitotic metaphase plate congression (GO:0007080)3.28941087
11bundle of His cell to Purkinje myocyte communication (GO:0086069)3.23453173
12retina vasculature morphogenesis in camera-type eye (GO:0061299)3.22911935
13hemidesmosome assembly (GO:0031581)3.22723233
14attachment of spindle microtubules to kinetochore (GO:0008608)3.21445385
15positive regulation of mitotic sister chromatid separation (GO:1901970)3.09636685
16positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.09636685
17positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.09636685
18wound healing, spreading of cells (GO:0044319)2.98944774
19meiotic chromosome segregation (GO:0045132)2.98757395
20melanin biosynthetic process (GO:0042438)2.96553807
21paraxial mesoderm development (GO:0048339)2.93883375
22metaphase plate congression (GO:0051310)2.93131150
23chondrocyte proliferation (GO:0035988)2.91328687
24regulation of mononuclear cell migration (GO:0071675)2.87101133
25epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.76012799
26mitotic sister chromatid cohesion (GO:0007064)2.73631764
27negative regulation of keratinocyte proliferation (GO:0010839)2.71775540
28neutrophil activation involved in immune response (GO:0002283)2.70810674
29COPII vesicle coating (GO:0048208)2.69658302
30cell adhesion mediated by integrin (GO:0033627)2.68506997
31kinetochore organization (GO:0051383)2.68110080
32modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.67292861
33positive regulation by organism of defense response of other organism involved in symbiotic interact2.67292861
34modulation by symbiont of host immune response (GO:0052553)2.67292861
35positive regulation by symbiont of host defense response (GO:0052509)2.67292861
36modulation by symbiont of host defense response (GO:0052031)2.67292861
37modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.67292861
38positive regulation of interferon-alpha production (GO:0032727)2.66499062
39positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.64897374
40positive regulation of chromosome segregation (GO:0051984)2.63867190
41morphogenesis of an epithelial sheet (GO:0002011)2.62213151
42regulation of cellular senescence (GO:2000772)2.60845197
43response to muscle activity (GO:0014850)2.58432732
44regulation of chemokine-mediated signaling pathway (GO:0070099)2.57425055
45prostate gland growth (GO:0060736)2.56564353
46secondary metabolite biosynthetic process (GO:0044550)2.54548767
47gap junction assembly (GO:0016264)2.52094978
48regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.51682107
49regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.50920287
50glomerular visceral epithelial cell development (GO:0072015)2.48800025
51positive regulation of protein autophosphorylation (GO:0031954)2.48643198
52ectoderm development (GO:0007398)2.47881066
53anterior/posterior axis specification, embryo (GO:0008595)2.47485022
54fibroblast migration (GO:0010761)2.46352001
55establishment of chromosome localization (GO:0051303)2.45895015
56CENP-A containing nucleosome assembly (GO:0034080)2.44854041
57regulation of interferon-alpha production (GO:0032647)2.44534852
58regulation of SMAD protein import into nucleus (GO:0060390)2.42083593
59maturation of 5.8S rRNA (GO:0000460)2.41546127
60positive regulation of SMAD protein import into nucleus (GO:0060391)2.41272292
61DNA topological change (GO:0006265)2.39542306
62pore complex assembly (GO:0046931)2.39418352
63cellular response to vitamin D (GO:0071305)2.39036782
64neural tube formation (GO:0001841)2.37258649
65negative regulation of hormone metabolic process (GO:0032351)2.36759185
66definitive hemopoiesis (GO:0060216)2.36055232
67regulation of sulfur metabolic process (GO:0042762)2.34951682
68melanin metabolic process (GO:0006582)2.34044256
69sequestering of extracellular ligand from receptor (GO:0035581)2.33262432
70negative regulation of B cell proliferation (GO:0030889)2.33034847
71regulation of transforming growth factor beta2 production (GO:0032909)2.32967405
72kinetochore assembly (GO:0051382)2.32774488
73polyketide metabolic process (GO:0030638)2.32708094
74doxorubicin metabolic process (GO:0044598)2.32708094
75daunorubicin metabolic process (GO:0044597)2.32708094
76Notch signaling involved in heart development (GO:0061314)2.31703341
77regulation of interferon-beta biosynthetic process (GO:0045357)2.30023463
78mitotic cell cycle arrest (GO:0071850)2.29570676
79mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.29239294
80mesodermal cell differentiation (GO:0048333)2.29031862
81myoblast migration (GO:0051451)2.28707651
82DNA damage induced protein phosphorylation (GO:0006975)2.27869597
83chromatin remodeling at centromere (GO:0031055)2.27744266
84artery development (GO:0060840)2.27264778
85regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.27118370
86notochord development (GO:0030903)2.26203417
87dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.25683969
88negative regulation of norepinephrine secretion (GO:0010700)2.22836684
89regulation of cell aging (GO:0090342)2.22382789
90regulation of translational termination (GO:0006449)2.21218606
91glomerular epithelial cell development (GO:0072310)2.21189977
92regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.20623387
93positive regulation of cellular amide metabolic process (GO:0034250)2.19658756
94embryonic axis specification (GO:0000578)2.19323063
95negative regulation of hormone biosynthetic process (GO:0032353)2.19161787
96hepatocyte apoptotic process (GO:0097284)2.18983011
97regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.17977201
98lysine metabolic process (GO:0006553)2.17952428
99lysine catabolic process (GO:0006554)2.17952428
100centriole replication (GO:0007099)2.17267733
101negative regulation of chondrocyte differentiation (GO:0032331)2.17148573
102outer ear morphogenesis (GO:0042473)2.16951985
103regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.16769726
104epithelial cell-cell adhesion (GO:0090136)2.16391159
105superoxide anion generation (GO:0042554)2.16060748
106regulation of RIG-I signaling pathway (GO:0039535)2.16012597
107regulation of non-canonical Wnt signaling pathway (GO:2000050)2.15786546
108B cell mediated immunity (GO:0019724)2.15487646
109female gonad development (GO:0008585)2.14619425
110actin-mediated cell contraction (GO:0070252)2.13659465
111centriole assembly (GO:0098534)2.13430438
112anterior/posterior axis specification (GO:0009948)2.13338063
113keratinocyte development (GO:0003334)2.13018589
114nuclear pore complex assembly (GO:0051292)2.12507335
115UDP-N-acetylglucosamine metabolic process (GO:0006047)2.11988706
116embryonic retina morphogenesis in camera-type eye (GO:0060059)2.11432870
117actomyosin structure organization (GO:0031032)2.11373526
118regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.11261208
119plasma membrane repair (GO:0001778)2.11257728
120regulation of acyl-CoA biosynthetic process (GO:0050812)2.10954870
121regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.10081507
122embryonic process involved in female pregnancy (GO:0060136)2.09619319
123cardiac epithelial to mesenchymal transition (GO:0060317)2.09511226
124histone-serine phosphorylation (GO:0035404)2.09499825
125gastrulation with mouth forming second (GO:0001702)2.09479882
126lymphangiogenesis (GO:0001946)2.09276160
127response to hepatocyte growth factor (GO:0035728)2.09164375
128cellular response to hepatocyte growth factor stimulus (GO:0035729)2.09164375
129regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.09073974
130regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.08690136
131cellular glucuronidation (GO:0052695)2.08245796
132hippo signaling (GO:0035329)2.07959597
133regulation of mitotic metaphase/anaphase transition (GO:0030071)2.07703361
134skin morphogenesis (GO:0043589)2.07637633
135phagocytosis, recognition (GO:0006910)2.07502958
136mesenchymal cell differentiation (GO:0048762)2.07268441
137regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.05773206
138mitotic G2 DNA damage checkpoint (GO:0007095)2.05772856
139response to muramyl dipeptide (GO:0032495)2.05450785
140ectodermal placode formation (GO:0060788)2.04876959
141phagocytosis, engulfment (GO:0006911)2.04570247
142positive regulation of lipid kinase activity (GO:0090218)2.04240940
143positive regulation of glycoprotein biosynthetic process (GO:0010560)2.04078094
144somatic stem cell division (GO:0048103)2.03827304
145regulation of T cell chemotaxis (GO:0010819)2.03734849
146positive regulation of T cell chemotaxis (GO:0010820)2.03734849
147positive regulation of glycolytic process (GO:0045821)2.03568809
148cell surface receptor signaling pathway involved in heart development (GO:0061311)2.03450958
149mitotic G2/M transition checkpoint (GO:0044818)2.03267645
150positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)2.02772465
151midgut development (GO:0007494)2.02399235
152regulation of heart morphogenesis (GO:2000826)2.02273174
153microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.02202239
154cellular response to interferon-alpha (GO:0035457)2.01986081
155dorsal/ventral axis specification (GO:0009950)2.00836252
156somite rostral/caudal axis specification (GO:0032525)2.00185779
157lens morphogenesis in camera-type eye (GO:0002089)1.99932228
158positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr1.99864403
159regulation of sister chromatid segregation (GO:0033045)1.99801754
160regulation of mitotic sister chromatid separation (GO:0010965)1.99801754
161regulation of mitotic sister chromatid segregation (GO:0033047)1.99801754
162cellular response to vitamin (GO:0071295)1.99132207
163keratinocyte proliferation (GO:0043616)1.99039873
164spindle checkpoint (GO:0031577)1.98981551
165immunoglobulin mediated immune response (GO:0016064)1.98900592
166regulation of mitotic spindle organization (GO:0060236)1.98389898
167genitalia morphogenesis (GO:0035112)1.97229220
168regulation of Rac protein signal transduction (GO:0035020)1.97184670
169regulation of bile acid biosynthetic process (GO:0070857)1.96455603
170positive regulation of catenin import into nucleus (GO:0035413)1.96156068
171cellular protein complex localization (GO:0034629)1.96053237
172protein localization to cell surface (GO:0034394)1.95630182
173regulation of Wnt signaling pathway involved in heart development (GO:0003307)1.95572599
174axon extension (GO:0048675)1.94272357
175transcytosis (GO:0045056)1.94095916
176intracellular lipid transport (GO:0032365)1.94028616
177zinc ion transport (GO:0006829)1.93203677
178regulation of relaxation of muscle (GO:1901077)1.93202891
179cellular response to ethanol (GO:0071361)1.93072142
180uronic acid metabolic process (GO:0006063)1.91902117
181glucuronate metabolic process (GO:0019585)1.91902117
182apical protein localization (GO:0045176)1.90775647
183regulation of keratinocyte proliferation (GO:0010837)1.89233634
184mesenchymal-epithelial cell signaling (GO:0060638)1.89121283
185actin filament-based movement (GO:0030048)1.88794167
186asymmetric protein localization (GO:0008105)1.88073633
187cell fate commitment involved in formation of primary germ layer (GO:0060795)1.87424216

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.53690734
2SALL1_21062744_ChIP-ChIP_HESCs_Human4.32950836
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.06994701
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.99573573
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.67563706
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.35728438
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.65664086
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.61118048
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.53817051
10AR_21909140_ChIP-Seq_LNCAP_Human2.49642810
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.43210672
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.36364065
13* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.32946527
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.32072738
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.25881675
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.18759913
17* PIAS1_25552417_ChIP-Seq_VCAP_Human2.11370886
18* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06262541
19EP300_21415370_ChIP-Seq_HL-1_Mouse1.99507828
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.99306370
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.97877666
22KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.95425687
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.94947053
24IRF8_27001747_Chip-Seq_BMDM_Mouse1.90449768
25SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.88464012
26CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.86443394
27WT1_19549856_ChIP-ChIP_CCG9911_Human1.84961404
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.75449826
29GBX2_23144817_ChIP-Seq_PC3_Human1.75322102
30OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.74260413
31CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.72701970
32TP63_19390658_ChIP-ChIP_HaCaT_Human1.71577030
33EWS_26573619_Chip-Seq_HEK293_Human1.69547130
34NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.69356850
35SALL4_18804426_ChIP-ChIP_XEN_Mouse1.69162563
36P300_19829295_ChIP-Seq_ESCs_Human1.64332852
37KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.61932545
38KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.61932545
39KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.61932545
40* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.60857688
41* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.60857688
42CJUN_26792858_Chip-Seq_BT549_Human1.55803949
43* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55538892
44STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.55220697
45ELK1_19687146_ChIP-ChIP_HELA_Human1.53397141
46RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52097361
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.51610485
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.51381226
49SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.50939020
50TP53_18474530_ChIP-ChIP_U2OS_Human1.49500134
51NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.48083054
52SMAD4_21799915_ChIP-Seq_A2780_Human1.47785176
53* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.46920187
54* BRD4_25478319_ChIP-Seq_HGPS_Human1.45320997
55FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.44563877
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42378840
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42216075
58TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41409744
59AHR_22903824_ChIP-Seq_MCF-7_Human1.40036863
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38506689
61ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.38184211
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35957227
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35953373
64E2F1_21310950_ChIP-Seq_MCF-7_Human1.35688107
65FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35397391
66TAF15_26573619_Chip-Seq_HEK293_Human1.35027096
67TP53_16413492_ChIP-PET_HCT116_Human1.32838634
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32552559
69VDR_24787735_ChIP-Seq_THP-1_Human1.30793684
70CDX2_20551321_ChIP-Seq_CACO-2_Human1.30068885
71STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.29002423
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28917496
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.28885462
74PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28797208
75TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.26037127
76IGF1R_20145208_ChIP-Seq_DFB_Human1.25959375
77IRF8_22096565_ChIP-ChIP_GC-B_Human1.25059562
78BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22559784
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.22369776
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.22297924
81SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22110058
82CDX2_22108803_ChIP-Seq_LS180_Human1.22064432
83NRF2_20460467_ChIP-Seq_MEFs_Mouse1.22033553
84NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.22033553
85SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.21722257
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.21260237
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20788607
88STAT3_23295773_ChIP-Seq_U87_Human1.19742044
89MYB_21317192_ChIP-Seq_ERMYB_Mouse1.19463731
90TCF3_18692474_ChIP-Seq_MEFs_Mouse1.19444422
91STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16342577
92BCAT_22108803_ChIP-Seq_LS180_Human1.15072072
93* SMAD3_21741376_ChIP-Seq_HESCs_Human1.14826260
94HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14612451
95* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.14572457
96CMYC_18555785_Chip-Seq_ESCs_Mouse1.14553871
97* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14238091
98* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13304399
99CTNNB1_20460455_ChIP-Seq_HCT116_Human1.12726608
100E2F1_18555785_Chip-Seq_ESCs_Mouse1.12714766
101TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11755519
102FUS_26573619_Chip-Seq_HEK293_Human1.11529446
103NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11487229
104EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.11006967
105TCF3_18692474_ChIP-Seq_MESCs_Mouse1.10744050
106MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.09427327
107TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08502715
108TBX3_20139965_ChIP-Seq_MESCs_Mouse1.07446577
109SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06949324
110TBX3_20139965_ChIP-Seq_ESCs_Mouse1.06681935
111CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06530188
112SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06266071
113P53_22387025_ChIP-Seq_ESCs_Mouse1.06098656
114* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.05983779
115MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.05795436
116NELFA_20434984_ChIP-Seq_ESCs_Mouse1.05238809
117* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05071738
118* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.05016396
119NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04041962
120NFE2_27457419_Chip-Seq_LIVER_Mouse1.03941883
121* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03905808
122FOXO3_23340844_ChIP-Seq_DLD1_Human1.03149675
123FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02782257
124CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00227142
125IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00191682
126ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99770587
127PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99145168
128TCF4_22108803_ChIP-Seq_LS180_Human0.98334077
129BRD4_27068464_Chip-Seq_AML-cells_Mouse0.97422307
130RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.96271119
131CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94737648
132TCF4_18268006_ChIP-ChIP_LS174T_Human0.94560929
133FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94555547
134* SOX2_20726797_ChIP-Seq_SW620_Human0.92386204
135STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.91600331
136SPI1_23547873_ChIP-Seq_NB4_Human0.91527590
137CLOCK_20551151_ChIP-Seq_293T_Human0.91001099
138SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.90513783
139RBPJ_22232070_ChIP-Seq_NCS_Mouse0.89711509
140TFEB_21752829_ChIP-Seq_HELA_Human0.89580202
141ESR1_21235772_ChIP-Seq_MCF-7_Human0.85340213
142ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.84453766
143* PU_27001747_Chip-Seq_BMDM_Mouse0.81821576
144HOXB4_20404135_ChIP-ChIP_EML_Mouse0.78913399
145PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.78828407
146GATA2_21666600_ChIP-Seq_HMVEC_Human0.78271142
147TP63_23658742_ChIP-Seq_EP156T_Human0.77212861
148* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.77190680
149MYC_18555785_ChIP-Seq_MESCs_Mouse0.76651853
150NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.76632240
151NANOG_16153702_ChIP-ChIP_HESCs_Human0.75772128
152SOX9_24532713_ChIP-Seq_HFSC_Mouse0.74709098
153FLI1_27457419_Chip-Seq_LIVER_Mouse0.74676795
154SOX17_20123909_ChIP-Seq_XEN_Mouse0.74602315
155* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74501027

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis3.08120497
2MP0005171_absent_coat_pigmentation2.97738925
3MP0010030_abnormal_orbit_morphology2.96120317
4MP0005408_hypopigmentation2.45837674
5MP0003183_abnormal_peptide_metabolism2.39868323
6MP0008057_abnormal_DNA_replication2.11970920
7MP0008007_abnormal_cellular_replicative2.10873789
8MP0008438_abnormal_cutaneous_collagen2.08081030
9MP0003950_abnormal_plasma_membrane1.98726896
10MP0000569_abnormal_digit_pigmentation1.92506337
11MP0003941_abnormal_skin_development1.85456033
12MP0003937_abnormal_limbs/digits/tail_de1.84014029
13MP0003123_paternal_imprinting1.77013419
14MP0000733_abnormal_muscle_development1.76196748
15MP0001346_abnormal_lacrimal_gland1.75114307
16MP0000383_abnormal_hair_follicle1.74157167
17MP0000372_irregular_coat_pigmentation1.73234047
18MP0002090_abnormal_vision1.71853386
19MP0003693_abnormal_embryo_hatching1.71108532
20MP0003705_abnormal_hypodermis_morpholog1.66593358
21MP0005257_abnormal_intraocular_pressure1.66311424
22MP0003195_calcinosis1.62404046
23MP0010678_abnormal_skin_adnexa1.61722716
24MP0009780_abnormal_chondrocyte_physiolo1.61214837
25MP0009053_abnormal_anal_canal1.60699088
26MP0005085_abnormal_gallbladder_physiolo1.58726367
27MP0003283_abnormal_digestive_organ1.54176785
28MP0005248_abnormal_Harderian_gland1.52433385
29MP0002938_white_spotting1.51617663
30MP0002009_preneoplasia1.51456897
31MP0005367_renal/urinary_system_phenotyp1.46707686
32MP0000516_abnormal_urinary_system1.46707686
33MP0010234_abnormal_vibrissa_follicle1.45359719
34MP0003077_abnormal_cell_cycle1.44524328
35MP0010368_abnormal_lymphatic_system1.43599028
36MP0002139_abnormal_hepatobiliary_system1.42233281
37MP0003453_abnormal_keratinocyte_physiol1.41328011
38MP0005409_darkened_coat_color1.39938614
39MP0000490_abnormal_crypts_of1.38519805
40MP0003566_abnormal_cell_adhesion1.38420340
41MP0010352_gastrointestinal_tract_polyps1.37716381
42MP0009250_abnormal_appendicular_skeleto1.32924554
43MP0010307_abnormal_tumor_latency1.32779932
44MP0000767_abnormal_smooth_muscle1.32566960
45MP0000579_abnormal_nail_morphology1.32342737
46MP0005360_urolithiasis1.32144807
47MP0003385_abnormal_body_wall1.31575337
48MP0008932_abnormal_embryonic_tissue1.30875783
49MP0003868_abnormal_feces_composition1.29680298
50MP0003755_abnormal_palate_morphology1.28908870
51MP0002102_abnormal_ear_morphology1.28520301
52MP0000537_abnormal_urethra_morphology1.28509345
53MP0004957_abnormal_blastocyst_morpholog1.28431825
54MP0004043_abnormal_pH_regulation1.28100480
55MP0000428_abnormal_craniofacial_morphol1.28013800
56MP0002177_abnormal_outer_ear1.22531748
57MP0003567_abnormal_fetal_cardiomyocyte1.20814457
58MP0006082_CNS_inflammation1.20788693
59MP0000432_abnormal_head_morphology1.20078399
60MP0003252_abnormal_bile_duct1.19630301
61MP0000462_abnormal_digestive_system1.17983485
62MP0000049_abnormal_middle_ear1.16462142
63MP0004270_analgesia1.16141665
64MP0003448_altered_tumor_morphology1.15834918
65MP0002092_abnormal_eye_morphology1.15068586
66MP0002896_abnormal_bone_mineralization1.14383275
67MP0002877_abnormal_melanocyte_morpholog1.13667942
68MP0005058_abnormal_lysosome_morphology1.12226404
69MP0005508_abnormal_skeleton_morphology1.12025852
70MP0005187_abnormal_penis_morphology1.12013801
71MP0003136_yellow_coat_color1.11675902
72MP0004808_abnormal_hematopoietic_stem1.10965768
73MP0002697_abnormal_eye_size1.10853406
74MP0001299_abnormal_eye_distance/1.09835103
75MP0005451_abnormal_body_composition1.09542609
76MP0005197_abnormal_uvea_morphology1.09253681
77MP0000350_abnormal_cell_proliferation1.09068700
78MP0004084_abnormal_cardiac_muscle1.08994889
79MP0000749_muscle_degeneration1.07855446
80MP0005365_abnormal_bile_salt1.07568315
81MP0010094_abnormal_chromosome_stability1.06297372
82MP0003890_abnormal_embryonic-extraembry1.06172412
83MP0002282_abnormal_trachea_morphology1.04938898
84MP0001915_intracranial_hemorrhage1.04640076
85MP0003303_peritoneal_inflammation1.02113465
86MP0001324_abnormal_eye_pigmentation1.01978256
87MP0000751_myopathy1.01599888
88MP0002249_abnormal_larynx_morphology1.01537590
89MP0002419_abnormal_innate_immunity1.01519484
90MP0002006_tumorigenesis1.01209810
91MP0004215_abnormal_myocardial_fiber1.00599385
92MP0002060_abnormal_skin_morphology0.99415757
93MP0001849_ear_inflammation0.98982639
94MP0001293_anophthalmia0.98234608
95MP0002932_abnormal_joint_morphology0.97141601
96MP0005174_abnormal_tail_pigmentation0.96986605
97MP0001666_abnormal_nutrient_absorption0.96964033
98MP0009697_abnormal_copulation0.96561888
99MP0003828_pulmonary_edema0.95937036
100MP0000627_abnormal_mammary_gland0.94772014
101MP0005275_abnormal_skin_tensile0.94345910
102MP0003111_abnormal_nucleus_morphology0.93483599
103MP0002277_abnormal_respiratory_mucosa0.93457792
104MP0002148_abnormal_hypersensitivity_rea0.92828399
105MP0000371_diluted_coat_color0.91973381
106MP0003935_abnormal_craniofacial_develop0.91738768
107MP0000467_abnormal_esophagus_morphology0.91693983
108MP0000762_abnormal_tongue_morphology0.91574402
109MP0001243_abnormal_dermal_layer0.90537487
110MP0003091_abnormal_cell_migration0.90477731
111MP0001286_abnormal_eye_development0.90241177
112MP0000015_abnormal_ear_pigmentation0.90194951
113MP0002085_abnormal_embryonic_tissue0.90118150
114MP0004272_abnormal_basement_membrane0.89411829
115MP0002098_abnormal_vibrissa_morphology0.89344018
116MP0003121_genomic_imprinting0.89034269
117MP0009384_cardiac_valve_regurgitation0.88919994
118MP0005076_abnormal_cell_differentiation0.88268056
119MP0004036_abnormal_muscle_relaxation0.87679549
120MP0009278_abnormal_bone_marrow0.87475920
121MP0004264_abnormal_extraembryonic_tissu0.87280679
122MP0001958_emphysema0.86837907
123MP0003279_aneurysm0.86709590
124MP0001175_abnormal_lung_morphology0.86169035
125MP0002084_abnormal_developmental_patter0.85768213
126MP0003718_maternal_effect0.85069005
127MP0001614_abnormal_blood_vessel0.84561445
128MP0006054_spinal_hemorrhage0.84430669
129MP0001984_abnormal_olfaction0.84423945
130MP0002095_abnormal_skin_pigmentation0.83948369
131MP0002925_abnormal_cardiovascular_devel0.83291581
132MP0000427_abnormal_hair_cycle0.82959265
133MP0002233_abnormal_nose_morphology0.82359673
134MP0002111_abnormal_tail_morphology0.82345965
135MP0000013_abnormal_adipose_tissue0.81820228
136MP0005623_abnormal_meninges_morphology0.81789663
137MP0002113_abnormal_skeleton_development0.81470883
138MP0000647_abnormal_sebaceous_gland0.81461577
139MP0008775_abnormal_heart_ventricle0.81373968
140MP0004197_abnormal_fetal_growth/weight/0.80539721
141MP0003943_abnormal_hepatobiliary_system0.79560963
142MP0004019_abnormal_vitamin_homeostasis0.77918109
143MP0004087_abnormal_muscle_fiber0.76793279
144MP0001186_pigmentation_phenotype0.76180509
145MP0002909_abnormal_adrenal_gland0.75235705
146MP0002234_abnormal_pharynx_morphology0.74694370
147MP0005023_abnormal_wound_healing0.74277308
148MP0004885_abnormal_endolymph0.73907375
149MP0006072_abnormal_retinal_apoptosis0.73507071
150MP0002269_muscular_atrophy0.73505806
151MP0000377_abnormal_hair_follicle0.72603332
152MP0002972_abnormal_cardiac_muscle0.71494819
153MP0002075_abnormal_coat/hair_pigmentati0.70369740
154MP0005620_abnormal_muscle_contractility0.68934078
155MP0001661_extended_life_span0.68570541
156MP0004782_abnormal_surfactant_physiolog0.67718836

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)3.46129772
2Right ventricular cardiomyopathy (HP:0011663)3.05552634
3Prostate neoplasm (HP:0100787)3.02581021
4Intrahepatic cholestasis (HP:0001406)2.89037755
5Blue irides (HP:0000635)2.83051980
6Type 1 muscle fiber predominance (HP:0003803)2.74357813
7Lip pit (HP:0100267)2.70188406
8White forelock (HP:0002211)2.67844612
9Glomerulonephritis (HP:0000099)2.65871814
10Patchy hypopigmentation of hair (HP:0011365)2.63627269
11Coronal craniosynostosis (HP:0004440)2.55183003
12Eczematoid dermatitis (HP:0000976)2.49716995
13Disinhibition (HP:0000734)2.46215113
14Ectopic kidney (HP:0000086)2.44967518
15Hematochezia (HP:0002573)2.43567496
16Vertebral arch anomaly (HP:0008438)2.42095167
17Papillary thyroid carcinoma (HP:0002895)2.37003508
18Recurrent abscess formation (HP:0002722)2.35255151
19Sparse lateral eyebrow (HP:0005338)2.29341223
20Recurrent cutaneous fungal infections (HP:0011370)2.27784730
21Chronic mucocutaneous candidiasis (HP:0002728)2.27784730
22Hypobetalipoproteinemia (HP:0003563)2.27338261
23Hypoplastic labia majora (HP:0000059)2.26863139
24Chromsome breakage (HP:0040012)2.24207322
25Spondylolisthesis (HP:0003302)2.21449319
26Complement deficiency (HP:0004431)2.20280123
27Mitral stenosis (HP:0001718)2.18988361
28Recurrent bacterial skin infections (HP:0005406)2.18708357
29Hypolipoproteinemia (HP:0010981)2.18470626
30Long clavicles (HP:0000890)2.13994666
31Hypoplastic ischia (HP:0003175)2.11742229
32Arterial tortuosity (HP:0005116)2.10145414
33Mixed hearing impairment (HP:0000410)2.10054458
34Synostosis involving bones of the feet (HP:0009140)2.08654609
35Synostosis involving bones of the lower limbs (HP:0009138)2.08654609
36Abnormality of the labia majora (HP:0012881)2.07211082
37Abnormality of the left ventricular outflow tract (HP:0011103)2.06324579
38Subaortic stenosis (HP:0001682)2.06324579
39Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.05978284
40Short 4th metacarpal (HP:0010044)2.05978284
41Abnormal auditory evoked potentials (HP:0006958)2.04778526
42Vascular tortuosity (HP:0004948)2.04601273
43Tarsal synostosis (HP:0008368)2.03534291
44Thin bony cortex (HP:0002753)2.02758248
45Cardiovascular calcification (HP:0011915)2.02466892
46Osteolytic defects of the phalanges of the hand (HP:0009771)2.01989094
47Osteolytic defects of the hand bones (HP:0009699)2.01989094
48Hypoglycemic seizures (HP:0002173)2.01363799
49Agnosia (HP:0010524)2.00817936
50Cupped ear (HP:0000378)2.00028238
51Premature rupture of membranes (HP:0001788)1.99915537
52Abnormality of incisor morphology (HP:0011063)1.99331564
53Chin dimple (HP:0010751)1.98843451
54Hepatoblastoma (HP:0002884)1.96129372
55Oligodactyly (hands) (HP:0001180)1.95955563
56Cervical subluxation (HP:0003308)1.94271892
57Recurrent gram-negative bacterial infections (HP:0005420)1.93866850
58Oligodactyly (HP:0012165)1.93031170
59Symptomatic seizures (HP:0011145)1.92287125
60Vascular calcification (HP:0004934)1.92280773
61Synostosis of carpal bones (HP:0005048)1.90769374
62Hypoalphalipoproteinemia (HP:0003233)1.89680562
63Hypoglycemic coma (HP:0001325)1.89627056
64Intestinal atresia (HP:0011100)1.87575511
65Chromosomal breakage induced by crosslinking agents (HP:0003221)1.86377420
66Vacuolated lymphocytes (HP:0001922)1.85534625
67Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.85287964
68Aplasia/Hypoplasia of the fovea (HP:0008060)1.84781456
69Hypoplasia of the fovea (HP:0007750)1.84781456
70Exercise-induced muscle cramps (HP:0003710)1.84336588
71Abnormality of proline metabolism (HP:0010907)1.83504626
72Hydroxyprolinuria (HP:0003080)1.83504626
73Absent radius (HP:0003974)1.83446816
74Spinal cord lesions (HP:0100561)1.82829359
75Syringomyelia (HP:0003396)1.82829359
76Recurrent skin infections (HP:0001581)1.82739015
77Hyperinsulinemic hypoglycemia (HP:0000825)1.82573396
78Absent forearm bone (HP:0003953)1.82480449
79Aplasia involving forearm bones (HP:0009822)1.82480449
80Birth length less than 3rd percentile (HP:0003561)1.82268202
81Epidermoid cyst (HP:0200040)1.81941462
82Aortic dissection (HP:0002647)1.81218968
83Abnormality of the calf musculature (HP:0001430)1.80646221
84Shallow orbits (HP:0000586)1.80307299
85Neonatal short-limb short stature (HP:0008921)1.80293891
86Atrophic scars (HP:0001075)1.80236705
87Conjugated hyperbilirubinemia (HP:0002908)1.80106411
88Fair hair (HP:0002286)1.79083508
89Autoimmune thrombocytopenia (HP:0001973)1.78522763
90Parakeratosis (HP:0001036)1.77788901
91Thick nail (HP:0001805)1.77585857
92Malignant gastrointestinal tract tumors (HP:0006749)1.77557393
93Gastrointestinal carcinoma (HP:0002672)1.77557393
94Abnormal biliary tract morphology (HP:0012440)1.76892607
95Abnormality of monocarboxylic acid metabolism (HP:0010996)1.76108055
96Mediastinal lymphadenopathy (HP:0100721)1.75641977
97Leiomyosarcoma (HP:0100243)1.75340978
98Uterine leiomyosarcoma (HP:0002891)1.75340978
99Bundle branch block (HP:0011710)1.73648564
100Abnormality of the nasal septum (HP:0000419)1.73446604
101Hyperglycemia (HP:0003074)1.73237798
102Aqueductal stenosis (HP:0002410)1.72968457
103Soft skin (HP:0000977)1.72197551
104Retrobulbar optic neuritis (HP:0100654)1.72011470
105Optic neuritis (HP:0100653)1.72011470
106Abnormality of glutamine family amino acid metabolism (HP:0010902)1.71576533
107Cerebral aneurysm (HP:0004944)1.70604268
108Abnormality of the ischium (HP:0003174)1.69949890
109Shoulder girdle muscle weakness (HP:0003547)1.69792357
110Abnormality of the distal phalanx of the thumb (HP:0009617)1.69651930
111Urethral obstruction (HP:0000796)1.69350597
112Generalized hypopigmentation of hair (HP:0011358)1.69002648
113Biliary tract neoplasm (HP:0100574)1.68185775
114Aplasia cutis congenita (HP:0001057)1.68184485
115Abnormal delayed hypersensitivity skin test (HP:0002963)1.68179249
116EMG: myopathic abnormalities (HP:0003458)1.67795733
117Thyroid carcinoma (HP:0002890)1.67789096
118Fat malabsorption (HP:0002630)1.67601550
119Calf muscle hypertrophy (HP:0008981)1.67194856
120Overgrowth (HP:0001548)1.66716919
121Abnormality of macrophages (HP:0004311)1.66657509
122Esophageal atresia (HP:0002032)1.65731434
123Microglossia (HP:0000171)1.65698597
124Labial hypoplasia (HP:0000066)1.65461561
125Mildly elevated creatine phosphokinase (HP:0008180)1.65023715
126Limb-girdle muscle atrophy (HP:0003797)1.62084809
127Preaxial foot polydactyly (HP:0001841)1.62049310
128Tibial bowing (HP:0002982)1.61077180
129Mesomelia (HP:0003027)1.61033616
130Rib fusion (HP:0000902)1.60676223
131Heterotopia (HP:0002282)1.60538501
132Proximal tubulopathy (HP:0000114)1.59960322
133Subacute progressive viral hepatitis (HP:0006572)1.59006724
134Pulmonary artery stenosis (HP:0004415)1.58755902
135Short nail (HP:0001799)1.58602179
136Hypophosphatemic rickets (HP:0004912)1.57904055
137Aplasia/Hypoplasia of the macula (HP:0008059)1.57418920
138Transitional cell carcinoma of the bladder (HP:0006740)1.57253781
139Pulmonic stenosis (HP:0001642)1.57047199
140Carpal synostosis (HP:0009702)1.56521593
141Muscle hypertrophy of the lower extremities (HP:0008968)1.56124183
142Bladder neoplasm (HP:0009725)1.56092819
143Bladder carcinoma (HP:0002862)1.56092819
144Abnormality of the antihelix (HP:0009738)1.56072079
145Albinism (HP:0001022)1.55242472
146Congenital sensorineural hearing impairment (HP:0008527)1.54519633
147Recurrent corneal erosions (HP:0000495)1.54433411
148Fused cervical vertebrae (HP:0002949)1.54136367
149Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.54122195
150Limb-girdle muscle weakness (HP:0003325)1.53540096
151Muscle fiber inclusion bodies (HP:0100299)1.53241615
152Breast hypoplasia (HP:0003187)1.52622303
153Asymmetry of the thorax (HP:0001555)1.52116047
154Abnormality of complement system (HP:0005339)1.51431763
155Adrenal hypoplasia (HP:0000835)1.50786707
156Round ear (HP:0100830)1.50780791
157Stenosis of the external auditory canal (HP:0000402)1.50591539
158Hypopigmentation of the fundus (HP:0007894)1.50360968
159Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.47708151
160Hypoplastic female external genitalia (HP:0012815)1.47300869
161Increased number of teeth (HP:0011069)1.47222281
162Aplasia involving bones of the extremities (HP:0009825)1.47125033
163Aplasia involving bones of the upper limbs (HP:0009823)1.47125033
164Aplasia of the phalanges of the hand (HP:0009802)1.47125033
165Distal lower limb muscle weakness (HP:0009053)1.46819776
166Recurrent fungal infections (HP:0002841)1.46438923
167Cortical dysplasia (HP:0002539)1.45622201
168Neoplasm of the small intestine (HP:0100833)1.45452546
169Myocardial infarction (HP:0001658)1.45368655
170Calcaneovalgus deformity (HP:0001848)1.45072249
171Abnormality of the phalanges of the hallux (HP:0010057)1.44905176
172Wrist flexion contracture (HP:0001239)1.44803586
173Down-sloping shoulders (HP:0200021)1.44407342
174Periodontitis (HP:0000704)1.44159906
175Hemivertebrae (HP:0002937)1.43725980
176Synostosis involving bones of the hand (HP:0004278)1.43533545
177Breast carcinoma (HP:0003002)1.43443471
178Orchitis (HP:0100796)1.43269943
179Follicular hyperkeratosis (HP:0007502)1.43146759
180Heterochromia iridis (HP:0001100)1.42974184
181Broad metatarsal (HP:0001783)1.41970924
182Uterine neoplasm (HP:0010784)1.41335537
183Systemic lupus erythematosus (HP:0002725)1.41170942
184Aplasia/Hypoplasia affecting the retina (HP:0008061)1.40966563
185Rimmed vacuoles (HP:0003805)1.39349305
186Centrally nucleated skeletal muscle fibers (HP:0003687)1.39342058
187Limited hip movement (HP:0008800)1.38907406

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.70580567
2MAP3K92.63605091
3MKNK12.54043233
4EIF2AK12.46205536
5STK32.35496673
6PBK2.27468563
7NEK92.24779652
8PDK22.18229604
9EIF2AK32.16345381
10BCR2.14736076
11ERBB32.13655625
12MST42.06308909
13ACVR1B2.05669362
14NUAK12.01879698
15AKT32.01245433
16BUB11.98649082
17ERBB41.95129262
18TRPM71.81086792
19MOS1.76377692
20CASK1.75468379
21BRSK21.70215711
22TTN1.69300176
23RPS6KA41.65607841
24DDR21.62793581
25EPHA21.60634953
26MET1.60461250
27YES11.59925750
28PIK3CA1.59864912
29STK101.59537250
30EPHB21.59230895
31MAP3K141.58097650
32MELK1.56446064
33MKNK21.56195315
34STK38L1.54080030
35TTK1.53125998
36STK241.47805391
37TGFBR21.44924708
38NEK21.36730241
39FRK1.36072697
40WEE11.34906921
41CDK81.34604573
42DMPK1.33583726
43NEK11.32905807
44CDK61.31001425
45TSSK61.27624520
46TRIM281.26743241
47IRAK21.23643351
48CDC71.23244501
49STK41.20854154
50PAK41.20685869
51CHUK1.17897794
52TAF11.14169596
53PHKG21.12200419
54PHKG11.12200419
55CDK121.10542281
56ZAK1.08247903
57TNIK1.06490073
58CLK11.05840633
59PTK21.05727734
60FGR1.04472519
61FER1.03972361
62MARK11.01927699
63KIT1.01419307
64MAP3K60.99907724
65CAMK1D0.98198060
66MAP3K80.98159018
67NTRK10.97916170
68MAP3K20.97235954
69NLK0.95915573
70TEC0.91336423
71IRAK10.90888607
72EIF2AK20.90778584
73LATS20.90386446
74PDGFRB0.89402767
75LMTK20.88943178
76CSK0.87631419
77PLK10.86905828
78CAMK1G0.86156030
79FGFR20.85445555
80PIM10.84427875
81KSR10.84365023
82MAP3K120.82580311
83MST1R0.80516244
84PLK20.80309942
85BMPR1B0.79050626
86CDK70.78992747
87BMX0.77704272
88CDK90.76292469
89PNCK0.75809569
90DYRK30.74629623
91AURKB0.74365914
92IKBKB0.74207391
93SRPK10.73362090
94IRAK40.73351971
95PLK30.72468049
96MARK30.71524297
97OBSCN0.71515360
98BRD40.70018324
99PIM20.68829533
100PRPF4B0.68670944
101TGFBR10.68206904
102BMPR20.67837978
103CHEK20.62783825
104RPS6KA50.62661896
105PLK40.60583072
106CSF1R0.60452104
107FGFR30.60444088
108WNK30.59828755
109ABL20.59010527
110CSNK1A1L0.58201740
111LIMK10.57217480
112ABL10.56955945
113PIK3CG0.54727574
114PRKAA20.54622507
115JAK30.50717325
116CSNK1G10.50333392
117STK390.50255614
118ATR0.49997941
119RPS6KB20.49320045
120PRKCE0.47292143
121LRRK20.47287228
122AKT20.46956760
123FGFR10.46795287
124NEK60.46659364
125TAOK20.46318310
126NTRK30.45765043
127BLK0.45542780
128ROCK20.45435530
129MYLK0.44647588
130DYRK1B0.44398927
131ERBB20.44141229
132PDGFRA0.43930630
133OXSR10.43389049
134ATM0.42737180
135MAP3K130.40961098
136CSNK1G20.40666415
137PAK20.39598613
138GSK3A0.38847745
139MAP3K30.38627679
140CHEK10.38511517
141MATK0.37676400
142ROCK10.37046315
143CAMK2D0.35427517
144PRKAA10.32407449
145MAP3K40.29045292
146EGFR0.28077204
147CDK30.27299969

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041102.36288759
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.12922941
3Histidine metabolism_Homo sapiens_hsa003402.01762625
4p53 signaling pathway_Homo sapiens_hsa041151.99412962
5TGF-beta signaling pathway_Homo sapiens_hsa043501.90055697
6Adherens junction_Homo sapiens_hsa045201.83222115
7MicroRNAs in cancer_Homo sapiens_hsa052061.82907820
8Leishmaniasis_Homo sapiens_hsa051401.73601275
9Homologous recombination_Homo sapiens_hsa034401.71237689
10Vitamin B6 metabolism_Homo sapiens_hsa007501.68150012
11Circadian rhythm_Homo sapiens_hsa047101.66853234
12Sulfur metabolism_Homo sapiens_hsa009201.63090207
13Protein export_Homo sapiens_hsa030601.59142563
14Hippo signaling pathway_Homo sapiens_hsa043901.57994375
15Fatty acid degradation_Homo sapiens_hsa000711.57507345
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.57217241
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.56097595
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.55556388
19RNA degradation_Homo sapiens_hsa030181.54761202
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.53243460
21Complement and coagulation cascades_Homo sapiens_hsa046101.49682382
22Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.48864627
23Tryptophan metabolism_Homo sapiens_hsa003801.48127337
24Small cell lung cancer_Homo sapiens_hsa052221.46497793
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.45495710
26DNA replication_Homo sapiens_hsa030301.42404448
27Malaria_Homo sapiens_hsa051441.41550881
28Starch and sucrose metabolism_Homo sapiens_hsa005001.40566636
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.40228437
30Basal cell carcinoma_Homo sapiens_hsa052171.39975313
31Arginine biosynthesis_Homo sapiens_hsa002201.38391781
32Transcriptional misregulation in cancer_Homo sapiens_hsa052021.38253472
33Mineral absorption_Homo sapiens_hsa049781.34761865
34Propanoate metabolism_Homo sapiens_hsa006401.33882113
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.32422135
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.30932812
37Viral myocarditis_Homo sapiens_hsa054161.29800186
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.29771385
39Chronic myeloid leukemia_Homo sapiens_hsa052201.29260919
40Pancreatic cancer_Homo sapiens_hsa052121.28693841
41Legionellosis_Homo sapiens_hsa051341.28680964
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28505976
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28354264
44Shigellosis_Homo sapiens_hsa051311.28272874
45Proteoglycans in cancer_Homo sapiens_hsa052051.28201061
46Non-homologous end-joining_Homo sapiens_hsa034501.27800307
47Phagosome_Homo sapiens_hsa041451.27460832
48Toll-like receptor signaling pathway_Homo sapiens_hsa046201.26826992
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.26656341
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.24723186
51Mismatch repair_Homo sapiens_hsa034301.23680701
52NOD-like receptor signaling pathway_Homo sapiens_hsa046211.23658867
53Notch signaling pathway_Homo sapiens_hsa043301.22545542
54PPAR signaling pathway_Homo sapiens_hsa033201.22364621
55Herpes simplex infection_Homo sapiens_hsa051681.22246194
56Tyrosine metabolism_Homo sapiens_hsa003501.22004827
57Basal transcription factors_Homo sapiens_hsa030221.21673322
58Protein digestion and absorption_Homo sapiens_hsa049741.20659459
59Tuberculosis_Homo sapiens_hsa051521.20397698
60Vitamin digestion and absorption_Homo sapiens_hsa049771.20080705
61Fatty acid metabolism_Homo sapiens_hsa012121.19850059
62Chemical carcinogenesis_Homo sapiens_hsa052041.18205846
63Retinol metabolism_Homo sapiens_hsa008301.18059639
64Caffeine metabolism_Homo sapiens_hsa002321.15788414
65Viral carcinogenesis_Homo sapiens_hsa052031.15737841
66Measles_Homo sapiens_hsa051621.15075464
67Systemic lupus erythematosus_Homo sapiens_hsa053221.14944327
68Pyruvate metabolism_Homo sapiens_hsa006201.14593955
69RNA transport_Homo sapiens_hsa030131.14512254
70ECM-receptor interaction_Homo sapiens_hsa045121.14282800
71Focal adhesion_Homo sapiens_hsa045101.14108356
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.13676201
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13001645
74Salmonella infection_Homo sapiens_hsa051321.12776084
75Arginine and proline metabolism_Homo sapiens_hsa003301.11476215
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10380285
77Hepatitis B_Homo sapiens_hsa051611.09730507
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.08984519
79Nucleotide excision repair_Homo sapiens_hsa034201.08350126
80Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.06850508
81Bladder cancer_Homo sapiens_hsa052191.06671884
82Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.05480552
83Bile secretion_Homo sapiens_hsa049761.05002211
84Osteoclast differentiation_Homo sapiens_hsa043801.03554131
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.02985100
86Lysine degradation_Homo sapiens_hsa003101.02924498
87beta-Alanine metabolism_Homo sapiens_hsa004101.02754256
88Staphylococcus aureus infection_Homo sapiens_hsa051501.01562437
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01528733
90Regulation of actin cytoskeleton_Homo sapiens_hsa048101.01488760
91Steroid biosynthesis_Homo sapiens_hsa001001.01457790
92Steroid hormone biosynthesis_Homo sapiens_hsa001401.00872846
93Fanconi anemia pathway_Homo sapiens_hsa034601.00818426
94Prostate cancer_Homo sapiens_hsa052151.00813961
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00127661
96Lysosome_Homo sapiens_hsa041420.99991687
97Other glycan degradation_Homo sapiens_hsa005110.99864818
98Pertussis_Homo sapiens_hsa051330.97750143
99Dorso-ventral axis formation_Homo sapiens_hsa043200.95475841
100Apoptosis_Homo sapiens_hsa042100.95344440
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94021973
102Dilated cardiomyopathy_Homo sapiens_hsa054140.93914429
103Butanoate metabolism_Homo sapiens_hsa006500.93385325
104Tight junction_Homo sapiens_hsa045300.93026896
105Toxoplasmosis_Homo sapiens_hsa051450.92946447
106HTLV-I infection_Homo sapiens_hsa051660.92402603
107TNF signaling pathway_Homo sapiens_hsa046680.92080873
108Sphingolipid metabolism_Homo sapiens_hsa006000.91772732
109Fat digestion and absorption_Homo sapiens_hsa049750.91601738
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91474628
111Influenza A_Homo sapiens_hsa051640.90499702
112Fatty acid biosynthesis_Homo sapiens_hsa000610.87891909
113Antigen processing and presentation_Homo sapiens_hsa046120.87748555
114Hedgehog signaling pathway_Homo sapiens_hsa043400.87124527
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87038110
116RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86064382
117Colorectal cancer_Homo sapiens_hsa052100.85738745
118Melanogenesis_Homo sapiens_hsa049160.85735175
119Renal cell carcinoma_Homo sapiens_hsa052110.85477372
120Renin-angiotensin system_Homo sapiens_hsa046140.83776020
121Base excision repair_Homo sapiens_hsa034100.83769012
122Melanoma_Homo sapiens_hsa052180.83646239
123Spliceosome_Homo sapiens_hsa030400.83477942
124Pathways in cancer_Homo sapiens_hsa052000.82640604
125Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81175025
126* Jak-STAT signaling pathway_Homo sapiens_hsa046300.80516718
127Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80081265
128Glucagon signaling pathway_Homo sapiens_hsa049220.79933911
129Amoebiasis_Homo sapiens_hsa051460.78769798
130Selenocompound metabolism_Homo sapiens_hsa004500.78686393
131Rheumatoid arthritis_Homo sapiens_hsa053230.78567599
132mRNA surveillance pathway_Homo sapiens_hsa030150.77847790
133Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77225609
134Epstein-Barr virus infection_Homo sapiens_hsa051690.76194484
135Drug metabolism - other enzymes_Homo sapiens_hsa009830.75951702
136Renin secretion_Homo sapiens_hsa049240.75836406
1372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74322973
138Graft-versus-host disease_Homo sapiens_hsa053320.74299425
139Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73970813
140Ether lipid metabolism_Homo sapiens_hsa005650.72925233
141Fatty acid elongation_Homo sapiens_hsa000620.72758499
142Thyroid hormone synthesis_Homo sapiens_hsa049180.71853640
143Phenylalanine metabolism_Homo sapiens_hsa003600.71539794
144Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71263074
145Wnt signaling pathway_Homo sapiens_hsa043100.70706672
146Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70296939
147PI3K-Akt signaling pathway_Homo sapiens_hsa041510.70131992
148Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69403082
149Galactose metabolism_Homo sapiens_hsa000520.67000167
150Endometrial cancer_Homo sapiens_hsa052130.66836507
151Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66746757
152Allograft rejection_Homo sapiens_hsa053300.65193821
153Arachidonic acid metabolism_Homo sapiens_hsa005900.64320538
154Hematopoietic cell lineage_Homo sapiens_hsa046400.63495787
155One carbon pool by folate_Homo sapiens_hsa006700.63420440
156FoxO signaling pathway_Homo sapiens_hsa040680.63222123
157Axon guidance_Homo sapiens_hsa043600.62628469
158B cell receptor signaling pathway_Homo sapiens_hsa046620.62015737
159Thyroid cancer_Homo sapiens_hsa052160.60035761
160Long-term depression_Homo sapiens_hsa047300.59826936
161Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59514870
162Autoimmune thyroid disease_Homo sapiens_hsa053200.57553665
163Glutathione metabolism_Homo sapiens_hsa004800.56870822
164Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55702545
165Prion diseases_Homo sapiens_hsa050200.52923233
166Insulin secretion_Homo sapiens_hsa049110.50285989
167cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48186912
168N-Glycan biosynthesis_Homo sapiens_hsa005100.46850742
169Cysteine and methionine metabolism_Homo sapiens_hsa002700.46305741
170Nitrogen metabolism_Homo sapiens_hsa009100.46245886
171Insulin resistance_Homo sapiens_hsa049310.45445411
172Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44938755
173Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43780240

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