

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | synaptic vesicle maturation (GO:0016188) | 5.52333938 |
| 2 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.22900394 |
| 3 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 5.14825586 |
| 4 | locomotory exploration behavior (GO:0035641) | 4.78098859 |
| 5 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 4.62451261 |
| 6 | proline transport (GO:0015824) | 4.36155234 |
| 7 | vocalization behavior (GO:0071625) | 4.34481819 |
| 8 | layer formation in cerebral cortex (GO:0021819) | 4.31402612 |
| 9 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 4.26438269 |
| 10 | glutamate secretion (GO:0014047) | 4.15277413 |
| 11 | protein localization to synapse (GO:0035418) | 4.06544161 |
| 12 | synaptic vesicle exocytosis (GO:0016079) | 4.03637373 |
| 13 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 3.93328823 |
| 14 | regulation of synaptic vesicle exocytosis (GO:2000300) | 3.88474518 |
| 15 | regulation of glutamate receptor signaling pathway (GO:1900449) | 3.88209953 |
| 16 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 3.78059268 |
| 17 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.75296209 |
| 18 | postsynaptic membrane organization (GO:0001941) | 3.72063167 |
| 19 | exploration behavior (GO:0035640) | 3.55570384 |
| 20 | synaptic transmission, glutamatergic (GO:0035249) | 3.53588654 |
| 21 | dendritic spine morphogenesis (GO:0060997) | 3.50761603 |
| 22 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 3.50731352 |
| 23 | positive regulation of synapse maturation (GO:0090129) | 3.49836405 |
| 24 | neurotransmitter secretion (GO:0007269) | 3.49671899 |
| 25 | neuron cell-cell adhesion (GO:0007158) | 3.49613902 |
| 26 | regulation of synaptic vesicle transport (GO:1902803) | 3.49270371 |
| 27 | glutamate receptor signaling pathway (GO:0007215) | 3.48308391 |
| 28 | neuronal action potential propagation (GO:0019227) | 3.45819874 |
| 29 | presynaptic membrane assembly (GO:0097105) | 3.33003500 |
| 30 | regulation of synapse structural plasticity (GO:0051823) | 3.31304615 |
| 31 | neuron-neuron synaptic transmission (GO:0007270) | 3.27923281 |
| 32 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.27856513 |
| 33 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.25594166 |
| 34 | sodium ion export (GO:0071436) | 3.23884296 |
| 35 | cellular potassium ion homeostasis (GO:0030007) | 3.23813303 |
| 36 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.21732687 |
| 37 | presynaptic membrane organization (GO:0097090) | 3.17140000 |
| 38 | regulation of cilium movement (GO:0003352) | 3.17111657 |
| 39 | cell migration in hindbrain (GO:0021535) | 3.16572560 |
| 40 | long-term memory (GO:0007616) | 3.15461032 |
| 41 | regulation of clathrin-mediated endocytosis (GO:2000369) | 3.13292961 |
| 42 | membrane depolarization during action potential (GO:0086010) | 3.11676170 |
| 43 | negative regulation of potassium ion transmembrane transport (GO:1901380) | 3.09155639 |
| 44 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.07181301 |
| 45 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.07087416 |
| 46 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.06893763 |
| 47 | synaptic vesicle endocytosis (GO:0048488) | 3.05752516 |
| 48 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.01931420 |
| 49 | neuromuscular process controlling balance (GO:0050885) | 3.01811111 |
| 50 | activation of protein kinase A activity (GO:0034199) | 3.00308987 |
| 51 | cerebellar granule cell differentiation (GO:0021707) | 3.00282946 |
| 52 | regulation of ARF protein signal transduction (GO:0032012) | 2.98722249 |
| 53 | L-amino acid import (GO:0043092) | 2.97074275 |
| 54 | neuronal ion channel clustering (GO:0045161) | 2.96919074 |
| 55 | neurotransmitter transport (GO:0006836) | 2.93901101 |
| 56 | gamma-aminobutyric acid transport (GO:0015812) | 2.92872154 |
| 57 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 2.92626379 |
| 58 | microtubule severing (GO:0051013) | 2.92586066 |
| 59 | neurotransmitter-gated ion channel clustering (GO:0072578) | 2.92334679 |
| 60 | prepulse inhibition (GO:0060134) | 2.91654317 |
| 61 | establishment of mitochondrion localization (GO:0051654) | 2.90736665 |
| 62 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 2.90635273 |
| 63 | mitochondrion transport along microtubule (GO:0047497) | 2.90635273 |
| 64 | neuron recognition (GO:0008038) | 2.90593822 |
| 65 | regulation of postsynaptic membrane potential (GO:0060078) | 2.90034652 |
| 66 | behavioral fear response (GO:0001662) | 2.87706079 |
| 67 | behavioral defense response (GO:0002209) | 2.87706079 |
| 68 | positive regulation of membrane potential (GO:0045838) | 2.87465535 |
| 69 | positive regulation of dendritic spine development (GO:0060999) | 2.86808009 |
| 70 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 2.86684706 |
| 71 | dendrite morphogenesis (GO:0048813) | 2.86302850 |
| 72 | regulation of NFAT protein import into nucleus (GO:0051532) | 2.82880548 |
| 73 | vesicle transport along microtubule (GO:0047496) | 2.82719360 |
| 74 | protein targeting to Golgi (GO:0000042) | 2.80808706 |
| 75 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 2.80530546 |
| 76 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 2.79912236 |
| 77 | cytoskeletal anchoring at plasma membrane (GO:0007016) | 2.79765625 |
| 78 | ventricular system development (GO:0021591) | 2.78982059 |
| 79 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 2.77452059 |
| 80 | regulation of synapse maturation (GO:0090128) | 2.75734883 |
| 81 | amino acid import (GO:0043090) | 2.74831779 |
| 82 | transmission of nerve impulse (GO:0019226) | 2.73647414 |
| 83 | regulation of synaptic plasticity (GO:0048167) | 2.73016203 |
| 84 | fear response (GO:0042596) | 2.73012502 |
| 85 | auditory behavior (GO:0031223) | 2.72790293 |
| 86 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 2.71941133 |
| 87 | striatum development (GO:0021756) | 2.70357051 |
| 88 | axonal fasciculation (GO:0007413) | 2.70046120 |
| 89 | innervation (GO:0060384) | 2.69091352 |
| 90 | regulation of neurotransmitter secretion (GO:0046928) | 2.68812890 |
| 91 | central nervous system myelination (GO:0022010) | 2.68618035 |
| 92 | axon ensheathment in central nervous system (GO:0032291) | 2.68618035 |
| 93 | embryonic retina morphogenesis in camera-type eye (GO:0060059) | 2.68502978 |
| 94 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 2.68116003 |
| 95 | maintenance of protein location in nucleus (GO:0051457) | 2.68069607 |
| 96 | chemosensory behavior (GO:0007635) | 2.67274157 |
| 97 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 2.67108059 |
| 98 | membrane depolarization (GO:0051899) | 2.66610984 |
| 99 | organelle transport along microtubule (GO:0072384) | 2.64943695 |
| 100 | calcium ion-dependent exocytosis (GO:0017156) | 2.62586193 |
| 101 | mating behavior (GO:0007617) | 2.61935339 |
| 102 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 2.61915059 |
| 103 | histone H3-K9 demethylation (GO:0033169) | 2.61733631 |
| 104 | establishment of nucleus localization (GO:0040023) | 2.61214949 |
| 105 | establishment of protein localization to Golgi (GO:0072600) | 2.60018862 |
| 106 | cochlea development (GO:0090102) | 2.59326730 |
| 107 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 2.59074008 |
| 108 | nerve growth factor signaling pathway (GO:0038180) | 2.58471633 |
| 109 | cell communication by electrical coupling (GO:0010644) | 2.56629803 |
| 110 | response to histamine (GO:0034776) | 2.56562172 |
| 111 | cell differentiation in hindbrain (GO:0021533) | 2.55829123 |
| 112 | pre-miRNA processing (GO:0031054) | 2.55489457 |
| 113 | intraspecies interaction between organisms (GO:0051703) | 2.55178569 |
| 114 | social behavior (GO:0035176) | 2.55178569 |
| 115 | regulation of calcium ion-dependent exocytosis (GO:0017158) | 2.54939176 |
| 116 | regulation of neurotransmitter levels (GO:0001505) | 2.54593491 |
| 117 | long-term synaptic potentiation (GO:0060291) | 2.54463196 |
| 118 | regulation of microtubule-based movement (GO:0060632) | 2.53145947 |
| 119 | synapse organization (GO:0050808) | 2.52302821 |
| 120 | regulation of vesicle fusion (GO:0031338) | 2.51857370 |
| 121 | cellular sodium ion homeostasis (GO:0006883) | 2.50308815 |
| 122 | negative regulation of histone methylation (GO:0031061) | 2.47961583 |
| 123 | mechanosensory behavior (GO:0007638) | 2.46327522 |
| 124 | apical protein localization (GO:0045176) | 2.45508537 |
| 125 | central nervous system projection neuron axonogenesis (GO:0021952) | 2.45430679 |
| 126 | negative regulation of dendrite morphogenesis (GO:0050774) | 2.45208460 |
| 127 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 2.42654555 |
| 128 | neuromuscular process (GO:0050905) | 2.41198669 |
| 129 | dendritic spine organization (GO:0097061) | 2.40664828 |
| 130 | neuromuscular synaptic transmission (GO:0007274) | 2.40366180 |
| 131 | potassium ion import (GO:0010107) | 2.39745744 |
| 132 | response to auditory stimulus (GO:0010996) | 2.38787890 |
| 133 | cerebellar Purkinje cell layer development (GO:0021680) | 2.37673841 |
| 134 | positive regulation of dendrite development (GO:1900006) | 2.37088532 |
| 135 | generation of neurons (GO:0048699) | 2.32758650 |
| 136 | regulation of dendrite morphogenesis (GO:0048814) | 2.31911468 |
| 137 | myotube differentiation (GO:0014902) | 2.31040285 |
| 138 | startle response (GO:0001964) | 2.30449405 |
| 139 | cell communication involved in cardiac conduction (GO:0086065) | 2.29551448 |
| 140 | positive regulation of dendrite morphogenesis (GO:0050775) | 2.27291586 |
| 141 | RNA localization (GO:0006403) | 2.25914441 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.58191032 |
| 2 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.63411158 |
| 3 | * RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.61743238 |
| 4 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 2.50714884 |
| 5 | * EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.43161666 |
| 6 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.32237972 |
| 7 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.29649307 |
| 8 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.23771357 |
| 9 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.23771357 |
| 10 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.17817938 |
| 11 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.10577107 |
| 12 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 2.08783180 |
| 13 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.06293174 |
| 14 | * MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.02161990 |
| 15 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.01376520 |
| 16 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.00995064 |
| 17 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 2.00522473 |
| 18 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.95093921 |
| 19 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.93106582 |
| 20 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.92350969 |
| 21 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.88121383 |
| 22 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.86913945 |
| 23 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.84190706 |
| 24 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.83036608 |
| 25 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 1.79060085 |
| 26 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 1.76591699 |
| 27 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.73757407 |
| 28 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.70970557 |
| 29 | * KDM2B_26808549_Chip-Seq_K562_Human | 1.69549135 |
| 30 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.59028165 |
| 31 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.57684915 |
| 32 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 1.54468589 |
| 33 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.50680848 |
| 34 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.50142003 |
| 35 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.45461605 |
| 36 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.45365032 |
| 37 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.41623176 |
| 38 | * ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.40758090 |
| 39 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.36944753 |
| 40 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.36318184 |
| 41 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 1.36064687 |
| 42 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.32731620 |
| 43 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.32731620 |
| 44 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.32731620 |
| 45 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.32636161 |
| 46 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.32580452 |
| 47 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.29138496 |
| 48 | * WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.28866960 |
| 49 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.28460398 |
| 50 | AR_19668381_ChIP-Seq_PC3_Human | 1.28226098 |
| 51 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.27595849 |
| 52 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.27507312 |
| 53 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.27429914 |
| 54 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.27044276 |
| 55 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.26855225 |
| 56 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 1.25753530 |
| 57 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.25224926 |
| 58 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.22675597 |
| 59 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.22637527 |
| 60 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.21507563 |
| 61 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.21329386 |
| 62 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.20759657 |
| 63 | ELK4_26923725_Chip-Seq_MESODERM_Mouse | 1.20650154 |
| 64 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.20575781 |
| 65 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.18202570 |
| 66 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.17505496 |
| 67 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.16577654 |
| 68 | RUNX1_26923725_Chip-Seq_HPCs_Mouse | 1.16445323 |
| 69 | * STAT3_23295773_ChIP-Seq_U87_Human | 1.15958285 |
| 70 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.15777747 |
| 71 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.15777747 |
| 72 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 1.14322410 |
| 73 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.14115142 |
| 74 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.11888177 |
| 75 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.10951876 |
| 76 | * KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.10857686 |
| 77 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 1.09040454 |
| 78 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.08660343 |
| 79 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.06608449 |
| 80 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.06502990 |
| 81 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.05602014 |
| 82 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 1.04718313 |
| 83 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.04330810 |
| 84 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.03652026 |
| 85 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.01835872 |
| 86 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 1.01178916 |
| 87 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.00319131 |
| 88 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.00151807 |
| 89 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.99499872 |
| 90 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.99488050 |
| 91 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.99293994 |
| 92 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.98663697 |
| 93 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.98405959 |
| 94 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 0.98197341 |
| 95 | CREB1_26743006_Chip-Seq_LNCaP_Human | 0.98035706 |
| 96 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 0.97334746 |
| 97 | TFAP2A_17053090_ChIP-ChIP_MCF-7_Human | 0.97118975 |
| 98 | CTCF_27219007_Chip-Seq_Bcells_Human | 0.96161963 |
| 99 | SMC4_20622854_ChIP-Seq_HELA_Human | 0.95925429 |
| 100 | SOX9_26525672_Chip-Seq_HEART_Mouse | 0.95888342 |
| 101 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.95675125 |
| 102 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.95645246 |
| 103 | * DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 0.95434104 |
| 104 | NANOG_18347094_ChIP-ChIP_MESCs_Mouse | 0.94732185 |
| 105 | TCF4_23295773_ChIP-Seq_U87_Human | 0.93298234 |
| 106 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 0.92819704 |
| 107 | * SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.91777514 |
| 108 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.90747241 |
| 109 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 0.89870335 |
| 110 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 0.89557772 |
| 111 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.89061630 |
| 112 | * TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.87954466 |
| 113 | PRDM14_21183938_ChIP-Seq_MESCs_Mouse | 0.87637423 |
| 114 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 0.87346330 |
| 115 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 0.86705893 |
| 116 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 0.86364302 |
| 117 | OCT4_19829295_ChIP-Seq_ESCs_Human | 0.86030123 |
| 118 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 0.85035713 |
| 119 | DPY_21335234_ChIP-Seq_ESCs_Mouse | 0.84431436 |
| 120 | E2F1_17053090_ChIP-ChIP_MCF-7_Human | 0.84224830 |
| 121 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 0.84190593 |
| 122 | * KDM2B_26808549_Chip-Seq_DND41_Human | 0.83514214 |
| 123 | FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human | 0.83054116 |
| 124 | POU5F1_16518401_ChIP-PET_MESCs_Mouse | 0.82596758 |
| 125 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.82259004 |
| 126 | WDR5_24793694_ChIP-Seq_LNCAP_Human | 0.82119610 |
| 127 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.81607113 |
| 128 | * CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.80988374 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 5.54786527 |
| 2 | MP0004270_analgesia | 3.84558126 |
| 3 | MP0003635_abnormal_synaptic_transmissio | 3.50579847 |
| 4 | MP0003880_abnormal_central_pattern | 3.20153765 |
| 5 | MP0009046_muscle_twitch | 2.92722776 |
| 6 | MP0002063_abnormal_learning/memory/cond | 2.86307345 |
| 7 | MP0004858_abnormal_nervous_system | 2.58796274 |
| 8 | MP0009745_abnormal_behavioral_response | 2.58646027 |
| 9 | MP0002064_seizures | 2.53353304 |
| 10 | MP0002734_abnormal_mechanical_nocicepti | 2.47781070 |
| 11 | MP0002572_abnormal_emotion/affect_behav | 2.47305786 |
| 12 | MP0001486_abnormal_startle_reflex | 2.29243795 |
| 13 | MP0005423_abnormal_somatic_nervous | 2.28083950 |
| 14 | MP0001968_abnormal_touch/_nociception | 2.23395268 |
| 15 | MP0005410_abnormal_fertilization | 2.17756887 |
| 16 | MP0002272_abnormal_nervous_system | 2.07930762 |
| 17 | MP0000566_synostosis | 2.05124799 |
| 18 | MP0002653_abnormal_ependyma_morphology | 2.02692436 |
| 19 | MP0003787_abnormal_imprinting | 1.93080020 |
| 20 | MP0002822_catalepsy | 1.88723940 |
| 21 | MP0005499_abnormal_olfactory_system | 1.87812170 |
| 22 | MP0005394_taste/olfaction_phenotype | 1.87812170 |
| 23 | MP0008961_abnormal_basal_metabolism | 1.84650956 |
| 24 | MP0002909_abnormal_adrenal_gland | 1.83415696 |
| 25 | MP0005409_darkened_coat_color | 1.82756224 |
| 26 | MP0002733_abnormal_thermal_nociception | 1.78966674 |
| 27 | MP0002184_abnormal_innervation | 1.78143474 |
| 28 | MP0001440_abnormal_grooming_behavior | 1.77387471 |
| 29 | MP0005551_abnormal_eye_electrophysiolog | 1.72367636 |
| 30 | MP0001501_abnormal_sleep_pattern | 1.71656897 |
| 31 | MP0000778_abnormal_nervous_system | 1.71596730 |
| 32 | MP0004145_abnormal_muscle_electrophysio | 1.68653829 |
| 33 | MP0002067_abnormal_sensory_capabilities | 1.65367890 |
| 34 | MP0001970_abnormal_pain_threshold | 1.62172365 |
| 35 | MP0004811_abnormal_neuron_physiology | 1.60250108 |
| 36 | MP0000537_abnormal_urethra_morphology | 1.56818068 |
| 37 | MP0003890_abnormal_embryonic-extraembry | 1.56741778 |
| 38 | MP0000955_abnormal_spinal_cord | 1.53940587 |
| 39 | MP0006292_abnormal_olfactory_placode | 1.53147491 |
| 40 | MP0003122_maternal_imprinting | 1.50918716 |
| 41 | MP0002736_abnormal_nociception_after | 1.50485782 |
| 42 | MP0008569_lethality_at_weaning | 1.48538659 |
| 43 | MP0003011_delayed_dark_adaptation | 1.47994462 |
| 44 | MP0002249_abnormal_larynx_morphology | 1.45693952 |
| 45 | MP0002882_abnormal_neuron_morphology | 1.45597657 |
| 46 | MP0002735_abnormal_chemical_nociception | 1.44579612 |
| 47 | MP0005386_behavior/neurological_phenoty | 1.42872354 |
| 48 | MP0004924_abnormal_behavior | 1.42872354 |
| 49 | MP0002557_abnormal_social/conspecific_i | 1.40239928 |
| 50 | MP0004885_abnormal_endolymph | 1.38636484 |
| 51 | MP0001984_abnormal_olfaction | 1.36873378 |
| 52 | MP0009780_abnormal_chondrocyte_physiolo | 1.32859318 |
| 53 | MP0010234_abnormal_vibrissa_follicle | 1.31748201 |
| 54 | MP0000579_abnormal_nail_morphology | 1.28558683 |
| 55 | MP0006072_abnormal_retinal_apoptosis | 1.28532808 |
| 56 | MP0000751_myopathy | 1.22898658 |
| 57 | MP0003646_muscle_fatigue | 1.22115420 |
| 58 | * MP0002066_abnormal_motor_capabilities/c | 1.21788906 |
| 59 | MP0005076_abnormal_cell_differentiation | 1.18981199 |
| 60 | MP0003329_amyloid_beta_deposits | 1.18817306 |
| 61 | * MP0002152_abnormal_brain_morphology | 1.15639282 |
| 62 | MP0004742_abnormal_vestibular_system | 1.15281294 |
| 63 | MP0005253_abnormal_eye_physiology | 1.13761148 |
| 64 | MP0003698_abnormal_male_reproductive | 1.13516829 |
| 65 | MP0002229_neurodegeneration | 1.12582049 |
| 66 | MP0002332_abnormal_exercise_endurance | 1.12407495 |
| 67 | MP0003119_abnormal_digestive_system | 1.09927791 |
| 68 | MP0003879_abnormal_hair_cell | 1.09694060 |
| 69 | MP0003121_genomic_imprinting | 1.09478910 |
| 70 | MP0009379_abnormal_foot_pigmentation | 1.06966716 |
| 71 | MP0005623_abnormal_meninges_morphology | 1.04894468 |
| 72 | MP0008057_abnormal_DNA_replication | 1.04585299 |
| 73 | MP0002752_abnormal_somatic_nervous | 1.04008454 |
| 74 | MP0004085_abnormal_heartbeat | 1.02369045 |
| 75 | MP0000534_abnormal_ureter_morphology | 1.01458222 |
| 76 | MP0004233_abnormal_muscle_weight | 1.01407903 |
| 77 | MP0009672_abnormal_birth_weight | 1.01192198 |
| 78 | MP0003283_abnormal_digestive_organ | 1.00746064 |
| 79 | MP0001188_hyperpigmentation | 0.99556477 |
| 80 | MP0001177_atelectasis | 0.98075803 |
| 81 | MP0004130_abnormal_muscle_cell | 0.97575386 |
| 82 | MP0004185_abnormal_adipocyte_glucose | 0.96904027 |
| 83 | MP0001346_abnormal_lacrimal_gland | 0.96659252 |
| 84 | MP0004264_abnormal_extraembryonic_tissu | 0.96017703 |
| 85 | MP0003633_abnormal_nervous_system | 0.95092440 |
| 86 | MP0004043_abnormal_pH_regulation | 0.95045064 |
| 87 | MP0003115_abnormal_respiratory_system | 0.94183124 |
| 88 | MP0003942_abnormal_urinary_system | 0.94144332 |
| 89 | * MP0003861_abnormal_nervous_system | 0.93810564 |
| 90 | MP0003137_abnormal_impulse_conducting | 0.91717408 |
| 91 | MP0001299_abnormal_eye_distance/ | 0.89815119 |
| 92 | MP0002081_perinatal_lethality | 0.88133110 |
| 93 | MP0001502_abnormal_circadian_rhythm | 0.87864932 |
| 94 | MP0008877_abnormal_DNA_methylation | 0.85455681 |
| 95 | MP0002254_reproductive_system_inflammat | 0.85122985 |
| 96 | MP0003632_abnormal_nervous_system | 0.84078057 |
| 97 | MP0003631_nervous_system_phenotype | 0.83711152 |
| 98 | MP0001485_abnormal_pinna_reflex | 0.83515436 |
| 99 | MP0002089_abnormal_postnatal_growth/wei | 0.82250145 |
| 100 | MP0006276_abnormal_autonomic_nervous | 0.80597480 |
| 101 | MP0002009_preneoplasia | 0.78953854 |
| 102 | MP0003938_abnormal_ear_development | 0.78824172 |
| 103 | MP0002090_abnormal_vision | 0.77990703 |
| 104 | MP0003937_abnormal_limbs/digits/tail_de | 0.77252429 |
| 105 | MP0002084_abnormal_developmental_patter | 0.77164555 |
| 106 | MP0010678_abnormal_skin_adnexa | 0.76846073 |
| 107 | MP0003123_paternal_imprinting | 0.76810030 |
| 108 | MP0004215_abnormal_myocardial_fiber | 0.76741504 |
| 109 | MP0003634_abnormal_glial_cell | 0.76351823 |
| 110 | MP0001929_abnormal_gametogenesis | 0.75873141 |
| 111 | MP0005646_abnormal_pituitary_gland | 0.75850173 |
| 112 | MP0005195_abnormal_posterior_eye | 0.74579387 |
| 113 | MP0005187_abnormal_penis_morphology | 0.74562476 |
| 114 | MP0003705_abnormal_hypodermis_morpholog | 0.74450015 |
| 115 | MP0003136_yellow_coat_color | 0.74406382 |
| 116 | * MP0010769_abnormal_survival | 0.74143297 |
| 117 | * MP0002069_abnormal_eating/drinking_beha | 0.73954138 |
| 118 | MP0001943_abnormal_respiration | 0.72720712 |
| 119 | MP0004142_abnormal_muscle_tone | 0.72036467 |
| 120 | * MP0002082_postnatal_lethality | 0.72029902 |
| 121 | * MP0010770_preweaning_lethality | 0.72029902 |
| 122 | MP0002234_abnormal_pharynx_morphology | 0.71630156 |
| 123 | MP0001348_abnormal_lacrimal_gland | 0.71575309 |
| 124 | MP0002697_abnormal_eye_size | 0.71203639 |
| 125 | MP0006035_abnormal_mitochondrial_morpho | 0.70806477 |
| 126 | MP0000749_muscle_degeneration | 0.70759418 |
| 127 | * MP0010768_mortality/aging | 0.70623071 |
| 128 | * MP0000631_abnormal_neuroendocrine_gland | 0.70392466 |
| 129 | MP0000383_abnormal_hair_follicle | 0.70352306 |
| 130 | MP0001529_abnormal_vocalization | 0.70138050 |
| 131 | MP0008874_decreased_physiological_sensi | 0.70026621 |
| 132 | MP0008872_abnormal_physiological_respon | 0.69159724 |
| 133 | MP0002269_muscular_atrophy | 0.68512510 |
| 134 | MP0002161_abnormal_fertility/fecundity | 0.67110440 |
| 135 | MP0000569_abnormal_digit_pigmentation | 0.66294939 |
| 136 | MP0001963_abnormal_hearing_physiology | 0.66294350 |
| 137 | MP0003045_fibrosis | 0.65527879 |
| 138 | MP0000759_abnormal_skeletal_muscle | 0.65415741 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of the lower motor neuron (HP:0002366) | 4.94708970 |
| 2 | Focal motor seizures (HP:0011153) | 4.66718630 |
| 3 | Myokymia (HP:0002411) | 4.54603384 |
| 4 | Focal seizures (HP:0007359) | 4.26501552 |
| 5 | Visual hallucinations (HP:0002367) | 3.96991781 |
| 6 | Epileptic encephalopathy (HP:0200134) | 3.80519611 |
| 7 | Febrile seizures (HP:0002373) | 3.67412261 |
| 8 | Atonic seizures (HP:0010819) | 3.39498254 |
| 9 | Amyotrophic lateral sclerosis (HP:0007354) | 3.31836648 |
| 10 | Progressive cerebellar ataxia (HP:0002073) | 3.29736857 |
| 11 | Amblyopia (HP:0000646) | 3.06025095 |
| 12 | Action tremor (HP:0002345) | 3.02592173 |
| 13 | Bilateral microphthalmos (HP:0007633) | 3.01986662 |
| 14 | Dialeptic seizures (HP:0011146) | 2.97033589 |
| 15 | Obstructive sleep apnea (HP:0002870) | 2.92088334 |
| 16 | Absence seizures (HP:0002121) | 2.90603130 |
| 17 | Hemiparesis (HP:0001269) | 2.90586999 |
| 18 | Hyperventilation (HP:0002883) | 2.88629656 |
| 19 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 2.85104870 |
| 20 | Hepatoblastoma (HP:0002884) | 2.84236890 |
| 21 | Generalized tonic-clonic seizures (HP:0002069) | 2.79055063 |
| 22 | Absent/shortened dynein arms (HP:0200106) | 2.75992652 |
| 23 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.75992652 |
| 24 | Difficulty running (HP:0009046) | 2.73350277 |
| 25 | Hyperacusis (HP:0010780) | 2.72015898 |
| 26 | Abnormality of the corticospinal tract (HP:0002492) | 2.65648140 |
| 27 | Dysdiadochokinesis (HP:0002075) | 2.59744274 |
| 28 | Supranuclear gaze palsy (HP:0000605) | 2.56212938 |
| 29 | Gaze-evoked nystagmus (HP:0000640) | 2.55737547 |
| 30 | Dysmetric saccades (HP:0000641) | 2.52745050 |
| 31 | Bronchomalacia (HP:0002780) | 2.51288884 |
| 32 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.50796109 |
| 33 | Broad-based gait (HP:0002136) | 2.48908133 |
| 34 | Neoplasm of the heart (HP:0100544) | 2.47535163 |
| 35 | Horizontal nystagmus (HP:0000666) | 2.47259936 |
| 36 | Excessive salivation (HP:0003781) | 2.44235436 |
| 37 | Drooling (HP:0002307) | 2.44235436 |
| 38 | Genetic anticipation (HP:0003743) | 2.40547620 |
| 39 | Abnormality of ocular smooth pursuit (HP:0000617) | 2.36618743 |
| 40 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.35975197 |
| 41 | Renovascular hypertension (HP:0100817) | 2.35749256 |
| 42 | Depression (HP:0000716) | 2.29926642 |
| 43 | Impaired smooth pursuit (HP:0007772) | 2.27271862 |
| 44 | Resting tremor (HP:0002322) | 2.27111454 |
| 45 | Ankle clonus (HP:0011448) | 2.26226152 |
| 46 | Abnormal respiratory motile cilium physiology (HP:0012261) | 2.26058898 |
| 47 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 2.25803905 |
| 48 | Insidious onset (HP:0003587) | 2.23247001 |
| 49 | Termporal pattern (HP:0011008) | 2.23247001 |
| 50 | Sensory axonal neuropathy (HP:0003390) | 2.21894537 |
| 51 | Turricephaly (HP:0000262) | 2.20168587 |
| 52 | Overriding aorta (HP:0002623) | 2.19877348 |
| 53 | Dyschromatopsia (HP:0007641) | 2.19837224 |
| 54 | Truncal ataxia (HP:0002078) | 2.18144996 |
| 55 | Increased nuchal translucency (HP:0010880) | 2.17668457 |
| 56 | Dysmetria (HP:0001310) | 2.15775195 |
| 57 | Poor eye contact (HP:0000817) | 2.15638233 |
| 58 | Aplasia involving bones of the extremities (HP:0009825) | 2.13932959 |
| 59 | Aplasia involving bones of the upper limbs (HP:0009823) | 2.13932959 |
| 60 | Aplasia of the phalanges of the hand (HP:0009802) | 2.13932959 |
| 61 | Apathy (HP:0000741) | 2.13235360 |
| 62 | Abnormality of the astrocytes (HP:0100707) | 2.10884679 |
| 63 | Astrocytoma (HP:0009592) | 2.10884679 |
| 64 | Absent speech (HP:0001344) | 2.08608077 |
| 65 | Spastic tetraparesis (HP:0001285) | 2.08159265 |
| 66 | Mutism (HP:0002300) | 2.07273421 |
| 67 | Elfin facies (HP:0004428) | 2.06951403 |
| 68 | Abnormal social behavior (HP:0012433) | 2.06404860 |
| 69 | Impaired social interactions (HP:0000735) | 2.06404860 |
| 70 | Vertebral arch anomaly (HP:0008438) | 2.05960087 |
| 71 | Neurofibrillary tangles (HP:0002185) | 2.03560994 |
| 72 | Obsessive-compulsive behavior (HP:0000722) | 2.02861841 |
| 73 | Ependymoma (HP:0002888) | 2.02360865 |
| 74 | Bowel incontinence (HP:0002607) | 2.02029366 |
| 75 | Pendular nystagmus (HP:0012043) | 2.00191096 |
| 76 | Germ cell neoplasia (HP:0100728) | 1.99243367 |
| 77 | Status epilepticus (HP:0002133) | 1.98988673 |
| 78 | Scotoma (HP:0000575) | 1.98893326 |
| 79 | Generalized hypotonia (HP:0001290) | 1.98841198 |
| 80 | Urethral obstruction (HP:0000796) | 1.97890233 |
| 81 | Truncal obesity (HP:0001956) | 1.97666551 |
| 82 | Hypochromic microcytic anemia (HP:0004840) | 1.96754452 |
| 83 | Insomnia (HP:0100785) | 1.95901478 |
| 84 | Urinary urgency (HP:0000012) | 1.94624448 |
| 85 | Central scotoma (HP:0000603) | 1.93628881 |
| 86 | Abnormal ciliary motility (HP:0012262) | 1.92562685 |
| 87 | Rapidly progressive (HP:0003678) | 1.92512424 |
| 88 | Impaired vibratory sensation (HP:0002495) | 1.90799607 |
| 89 | Tetraplegia (HP:0002445) | 1.90249459 |
| 90 | Renal duplication (HP:0000075) | 1.90040075 |
| 91 | Generalized myoclonic seizures (HP:0002123) | 1.90026257 |
| 92 | Neuronal loss in central nervous system (HP:0002529) | 1.89559712 |
| 93 | Thickened helices (HP:0000391) | 1.89455521 |
| 94 | Intention tremor (HP:0002080) | 1.89436478 |
| 95 | Spastic gait (HP:0002064) | 1.89265896 |
| 96 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 1.88222216 |
| 97 | Shallow orbits (HP:0000586) | 1.87628242 |
| 98 | Inappropriate behavior (HP:0000719) | 1.87408258 |
| 99 | EMG: neuropathic changes (HP:0003445) | 1.86950714 |
| 100 | Cerebral inclusion bodies (HP:0100314) | 1.86679490 |
| 101 | Postural instability (HP:0002172) | 1.86485393 |
| 102 | Congenital stationary night blindness (HP:0007642) | 1.86191531 |
| 103 | Heterotopia (HP:0002282) | 1.85595081 |
| 104 | Achilles tendon contracture (HP:0001771) | 1.85499159 |
| 105 | Limb dystonia (HP:0002451) | 1.85480570 |
| 106 | Lower limb muscle weakness (HP:0007340) | 1.83446630 |
| 107 | Megalencephaly (HP:0001355) | 1.83254918 |
| 108 | Cutaneous finger syndactyly (HP:0010554) | 1.82627807 |
| 109 | Ventricular fibrillation (HP:0001663) | 1.82597789 |
| 110 | Distal upper limb amyotrophy (HP:0007149) | 1.81833453 |
| 111 | Upper limb amyotrophy (HP:0009129) | 1.81833453 |
| 112 | Annular pancreas (HP:0001734) | 1.81035749 |
| 113 | Pheochromocytoma (HP:0002666) | 1.80988592 |
| 114 | Hand muscle atrophy (HP:0009130) | 1.78508769 |
| 115 | Diminished motivation (HP:0000745) | 1.78282508 |
| 116 | Exercise-induced myalgia (HP:0003738) | 1.77262278 |
| 117 | Intellectual disability, profound (HP:0002187) | 1.75995452 |
| 118 | Stereotypic behavior (HP:0000733) | 1.75792832 |
| 119 | Bundle branch block (HP:0011710) | 1.75399878 |
| 120 | Fetal akinesia sequence (HP:0001989) | 1.75200773 |
| 121 | Macroorchidism (HP:0000053) | 1.74768228 |
| 122 | Testicular atrophy (HP:0000029) | 1.74676169 |
| 123 | Abnormal large intestine physiology (HP:0012700) | 1.74281781 |
| 124 | Tracheomalacia (HP:0002779) | 1.73954258 |
| 125 | Rhinitis (HP:0012384) | 1.73916749 |
| 126 | Hyperkalemia (HP:0002153) | 1.72482151 |
| 127 | Midline defect of the nose (HP:0004122) | 1.72252375 |
| 128 | Epileptiform EEG discharges (HP:0011182) | 1.72190450 |
| 129 | Sporadic (HP:0003745) | 1.71629994 |
| 130 | Cutaneous syndactyly (HP:0012725) | 1.71302642 |
| 131 | Sleep apnea (HP:0010535) | 1.71127257 |
| 132 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.69285671 |
| 133 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.69285671 |
| 134 | Pointed chin (HP:0000307) | 1.68375261 |
| 135 | Morphological abnormality of the pyramidal tract (HP:0002062) | 1.68020275 |
| 136 | Abnormality of chromosome segregation (HP:0002916) | 1.67095995 |
| 137 | Deeply set eye (HP:0000490) | 1.66290547 |
| 138 | Ankyloglossia (HP:0010296) | 1.65925580 |
| 139 | Subaortic stenosis (HP:0001682) | 1.64234928 |
| 140 | Abnormality of the left ventricular outflow tract (HP:0011103) | 1.64234928 |
| 141 | High anterior hairline (HP:0009890) | 1.63856991 |
| 142 | Choanal stenosis (HP:0000452) | 1.61487837 |
| 143 | Attention deficit hyperactivity disorder (HP:0007018) | 1.60301117 |
| 144 | Trigonocephaly (HP:0000243) | 1.59235189 |
| 145 | Precocious puberty (HP:0000826) | 1.59139106 |
| 146 | Cubitus valgus (HP:0002967) | 1.58219333 |
| 147 | EEG with generalized epileptiform discharges (HP:0011198) | 1.57123533 |
| 148 | Partial agenesis of the corpus callosum (HP:0001338) | 1.55852518 |
| 149 | Lower limb amyotrophy (HP:0007210) | 1.55816788 |
| 150 | Protruding tongue (HP:0010808) | 1.55075258 |
| 151 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 1.54545909 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MAP3K9 | 3.93689393 |
| 2 | CDK12 | 3.33323488 |
| 3 | NTRK3 | 3.12506714 |
| 4 | GRK5 | 3.08342225 |
| 5 | EPHA4 | 3.04646889 |
| 6 | PRKD3 | 2.66071287 |
| 7 | CASK | 2.64176473 |
| 8 | MARK1 | 2.62429867 |
| 9 | TYRO3 | 2.60773667 |
| 10 | MAP3K4 | 2.52866068 |
| 11 | PAK6 | 2.40671360 |
| 12 | EEF2K | 2.33755915 |
| 13 | KSR2 | 2.18145689 |
| 14 | CAMK1D | 2.11572061 |
| 15 | NTRK1 | 2.04883465 |
| 16 | MAP2K4 | 2.00922477 |
| 17 | NTRK2 | 1.98460601 |
| 18 | STK38 | 1.92558797 |
| 19 | LATS2 | 1.82116957 |
| 20 | SIK2 | 1.78667217 |
| 21 | DAPK2 | 1.74932989 |
| 22 | MINK1 | 1.71324249 |
| 23 | WNK1 | 1.57116298 |
| 24 | TAOK1 | 1.47334752 |
| 25 | MARK2 | 1.45904441 |
| 26 | BRD4 | 1.45021488 |
| 27 | CAMKK1 | 1.44620221 |
| 28 | MAP2K7 | 1.40652673 |
| 29 | RIPK4 | 1.39300661 |
| 30 | PDK4 | 1.38722759 |
| 31 | PDK3 | 1.38722759 |
| 32 | ICK | 1.23844704 |
| 33 | KSR1 | 1.23698226 |
| 34 | FGFR2 | 1.20991293 |
| 35 | PNCK | 1.20690560 |
| 36 | RIPK1 | 1.14350036 |
| 37 | CDK5 | 1.13681778 |
| 38 | GRK6 | 1.10474051 |
| 39 | PHKG2 | 1.10252255 |
| 40 | PHKG1 | 1.10252255 |
| 41 | GRK1 | 1.08664445 |
| 42 | MET | 1.05937816 |
| 43 | NEK6 | 1.05082311 |
| 44 | MOS | 0.97977230 |
| 45 | CAMK4 | 0.95920629 |
| 46 | SIK1 | 0.94512151 |
| 47 | STK11 | 0.94416246 |
| 48 | CAMK1G | 0.92545373 |
| 49 | MTOR | 0.92386708 |
| 50 | ALK | 0.88893422 |
| 51 | MAPK7 | 0.88691969 |
| 52 | MAP3K2 | 0.86474633 |
| 53 | PRKCG | 0.86007865 |
| 54 | RET | 0.83053072 |
| 55 | MAPK13 | 0.78605638 |
| 56 | ARAF | 0.77617820 |
| 57 | GRK7 | 0.77569061 |
| 58 | MAP3K7 | 0.77384219 |
| 59 | MAP3K6 | 0.77110289 |
| 60 | HIPK2 | 0.75338009 |
| 61 | RAF1 | 0.74595639 |
| 62 | SMG1 | 0.73543424 |
| 63 | PRPF4B | 0.71154473 |
| 64 | TNIK | 0.70496908 |
| 65 | CDK15 | 0.70156052 |
| 66 | DMPK | 0.69774819 |
| 67 | PTK2B | 0.69580915 |
| 68 | ADRBK2 | 0.69470108 |
| 69 | LATS1 | 0.69430762 |
| 70 | PLK2 | 0.68843960 |
| 71 | PDK1 | 0.68594506 |
| 72 | DYRK1A | 0.68522696 |
| 73 | PRKCH | 0.67373065 |
| 74 | PAK3 | 0.66726943 |
| 75 | DAPK1 | 0.66395803 |
| 76 | CDK18 | 0.65541252 |
| 77 | UHMK1 | 0.65083098 |
| 78 | MAPK10 | 0.62603293 |
| 79 | PKN1 | 0.62279793 |
| 80 | CAMKK2 | 0.61834178 |
| 81 | CAMK2B | 0.61580275 |
| 82 | PDGFRB | 0.61156107 |
| 83 | CDK14 | 0.61069304 |
| 84 | MAP3K13 | 0.60848579 |
| 85 | CAMK1 | 0.59523530 |
| 86 | CDK11A | 0.59153478 |
| 87 | RPS6KB1 | 0.59054854 |
| 88 | SGK494 | 0.59010250 |
| 89 | SGK223 | 0.59010250 |
| 90 | SGK3 | 0.56167051 |
| 91 | PDK2 | 0.55454458 |
| 92 | CDK3 | 0.55107798 |
| 93 | BRAF | 0.55060779 |
| 94 | SGK1 | 0.54217822 |
| 95 | PRKD2 | 0.53440256 |
| 96 | RPS6KA3 | 0.53232956 |
| 97 | CAMK2A | 0.52861867 |
| 98 | OBSCN | 0.52829649 |
| 99 | SGK2 | 0.52020723 |
| 100 | MAPK12 | 0.51252425 |
| 101 | CDK1 | 0.50726674 |
| 102 | PRKAA1 | 0.50585761 |
| 103 | CDK2 | 0.48585199 |
| 104 | CDK7 | 0.46959132 |
| 105 | STK39 | 0.46701081 |
| 106 | TRIB3 | 0.45855591 |
| 107 | FGFR3 | 0.45530745 |
| 108 | MAPK8 | 0.44970312 |
| 109 | TTK | 0.43733922 |
| 110 | ERBB2 | 0.43067282 |
| 111 | PDPK1 | 0.42845302 |
| 112 | ADRBK1 | 0.42807508 |
| 113 | MATK | 0.42773894 |
| 114 | NEK2 | 0.42716417 |
| 115 | FES | 0.41911490 |
| 116 | DYRK2 | 0.41005168 |
| 117 | CHEK1 | 0.40373987 |
| 118 | PDGFRA | 0.39345766 |
| 119 | CDK19 | 0.38989759 |
| 120 | TSSK6 | 0.38512732 |
| 121 | AKT3 | 0.38391680 |
| 122 | MAP3K10 | 0.37831597 |
| 123 | PINK1 | 0.36745872 |
| 124 | CSNK1E | 0.35674049 |
| 125 | GSK3B | 0.35350870 |
| 126 | WNK4 | 0.33794358 |
| 127 | BMPR2 | 0.33675571 |
| 128 | CHEK2 | 0.33171011 |
| 129 | PRKCZ | 0.32202304 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 2.79452996 |
| 2 | Long-term potentiation_Homo sapiens_hsa04720 | 2.51485336 |
| 3 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.40552860 |
| 4 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.37495140 |
| 5 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.25091136 |
| 6 | Olfactory transduction_Homo sapiens_hsa04740 | 2.22626057 |
| 7 | GABAergic synapse_Homo sapiens_hsa04727 | 2.22561766 |
| 8 | Circadian entrainment_Homo sapiens_hsa04713 | 2.21849230 |
| 9 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.09618873 |
| 10 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.04800961 |
| 11 | Morphine addiction_Homo sapiens_hsa05032 | 1.96126490 |
| 12 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.88584997 |
| 13 | Phototransduction_Homo sapiens_hsa04744 | 1.84478961 |
| 14 | Salivary secretion_Homo sapiens_hsa04970 | 1.81268225 |
| 15 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.75432162 |
| 16 | Insulin secretion_Homo sapiens_hsa04911 | 1.69852131 |
| 17 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.68767994 |
| 18 | Long-term depression_Homo sapiens_hsa04730 | 1.67395780 |
| 19 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.64507141 |
| 20 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.63492384 |
| 21 | Taste transduction_Homo sapiens_hsa04742 | 1.61592195 |
| 22 | Renin secretion_Homo sapiens_hsa04924 | 1.60585823 |
| 23 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.58832589 |
| 24 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.53202468 |
| 25 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.47800666 |
| 26 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.45821239 |
| 27 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.44041657 |
| 28 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.42582190 |
| 29 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.40809196 |
| 30 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.38843610 |
| 31 | mTOR signaling pathway_Homo sapiens_hsa04150 | 1.36933031 |
| 32 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.36775298 |
| 33 | Cocaine addiction_Homo sapiens_hsa05030 | 1.35055596 |
| 34 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.30036119 |
| 35 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.29400525 |
| 36 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.21291903 |
| 37 | Glioma_Homo sapiens_hsa05214 | 1.19472375 |
| 38 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.19314880 |
| 39 | Gap junction_Homo sapiens_hsa04540 | 1.18563621 |
| 40 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.17907761 |
| 41 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 1.17223192 |
| 42 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.17177139 |
| 43 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 1.15108766 |
| 44 | Lysine degradation_Homo sapiens_hsa00310 | 1.13534927 |
| 45 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.12579926 |
| 46 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.09780124 |
| 47 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.07701097 |
| 48 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.07434716 |
| 49 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 1.05639605 |
| 50 | VEGF signaling pathway_Homo sapiens_hsa04370 | 1.04764337 |
| 51 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.03372930 |
| 52 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 1.03122044 |
| 53 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 1.02783153 |
| 54 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.02756846 |
| 55 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.98586969 |
| 56 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.97475569 |
| 57 | Axon guidance_Homo sapiens_hsa04360 | 0.96770797 |
| 58 | Adherens junction_Homo sapiens_hsa04520 | 0.95692568 |
| 59 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.94976537 |
| 60 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.94302209 |
| 61 | Melanogenesis_Homo sapiens_hsa04916 | 0.94144082 |
| 62 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.93476001 |
| 63 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.89884567 |
| 64 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.87940330 |
| 65 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.85220412 |
| 66 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.85105625 |
| 67 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.82075516 |
| 68 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.81905316 |
| 69 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.81281425 |
| 70 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.79242640 |
| 71 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.79161045 |
| 72 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.77357980 |
| 73 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.76385761 |
| 74 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.76374323 |
| 75 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.75660975 |
| 76 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.74905217 |
| 77 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.74084843 |
| 78 | Thyroid cancer_Homo sapiens_hsa05216 | 0.71963559 |
| 79 | Endometrial cancer_Homo sapiens_hsa05213 | 0.70564087 |
| 80 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.70211299 |
| 81 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.69905896 |
| 82 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.68172963 |
| 83 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.65752809 |
| 84 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.65009094 |
| 85 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.64899465 |
| 86 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.63755220 |
| 87 | Prostate cancer_Homo sapiens_hsa05215 | 0.62898399 |
| 88 | Circadian rhythm_Homo sapiens_hsa04710 | 0.61943355 |
| 89 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.61748409 |
| 90 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.61355918 |
| 91 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.58928461 |
| 92 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.58500428 |
| 93 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.58253123 |
| 94 | Endocytosis_Homo sapiens_hsa04144 | 0.57996459 |
| 95 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.57104997 |
| 96 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.57020241 |
| 97 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.57010838 |
| 98 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.56312138 |
| 99 | * Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.55903752 |
| 100 | Prion diseases_Homo sapiens_hsa05020 | 0.54782020 |
| 101 | Colorectal cancer_Homo sapiens_hsa05210 | 0.54629475 |
| 102 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.53006322 |
| 103 | Cell cycle_Homo sapiens_hsa04110 | 0.52939614 |
| 104 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.46743090 |
| 105 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.46151394 |
| 106 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.45369871 |
| 107 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.42674959 |
| 108 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.42371701 |
| 109 | Tight junction_Homo sapiens_hsa04530 | 0.41955891 |
| 110 | Alcoholism_Homo sapiens_hsa05034 | 0.41681369 |
| 111 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.40692621 |
| 112 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.37475626 |
| 113 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.36539502 |
| 114 | Bile secretion_Homo sapiens_hsa04976 | 0.36061845 |
| 115 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.34882052 |
| 116 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.34771435 |

