SOD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.31746291
2energy coupled proton transport, down electrochemical gradient (GO:0015985)6.37489802
3ATP synthesis coupled proton transport (GO:0015986)6.37489802
4response to nitrosative stress (GO:0051409)6.28771450
5glucuronate metabolic process (GO:0019585)5.90602684
6uronic acid metabolic process (GO:0006063)5.90602684
7xenobiotic catabolic process (GO:0042178)5.83296587
8ribosomal small subunit assembly (GO:0000028)5.67551101
9mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.62652810
10respiratory electron transport chain (GO:0022904)5.45463140
11electron transport chain (GO:0022900)5.34766138
12cellular glucuronidation (GO:0052695)5.33282481
13viral transcription (GO:0019083)5.29272930
14translational termination (GO:0006415)5.13600063
15ribosomal small subunit biogenesis (GO:0042274)5.07347531
16establishment of protein localization to mitochondrial membrane (GO:0090151)4.96472786
17chaperone-mediated protein transport (GO:0072321)4.89817255
18SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.82112437
19cotranslational protein targeting to membrane (GO:0006613)4.79323380
20protein targeting to ER (GO:0045047)4.72814632
21establishment of protein localization to endoplasmic reticulum (GO:0072599)4.54730201
22maturation of SSU-rRNA (GO:0030490)4.53829946
23protein localization to endoplasmic reticulum (GO:0070972)4.51289350
24kinetochore assembly (GO:0051382)4.50922134
25translational elongation (GO:0006414)4.46495240
26kinetochore organization (GO:0051383)4.35178233
27ribosomal large subunit biogenesis (GO:0042273)4.29183844
28sulfur amino acid catabolic process (GO:0000098)4.27220872
29aldehyde catabolic process (GO:0046185)4.22797946
30protein complex biogenesis (GO:0070271)4.07243700
31cellular protein complex disassembly (GO:0043624)4.05611044
32DNA deamination (GO:0045006)4.02835141
33serine family amino acid catabolic process (GO:0009071)3.99756416
34viral life cycle (GO:0019058)3.98255560
35nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.92954436
36mitochondrial respiratory chain complex assembly (GO:0033108)3.91047973
37translational initiation (GO:0006413)3.89900804
38ATP biosynthetic process (GO:0006754)3.87658887
39mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.86640623
40mitochondrial respiratory chain complex I assembly (GO:0032981)3.86640623
41NADH dehydrogenase complex assembly (GO:0010257)3.86640623
42benzene-containing compound metabolic process (GO:0042537)3.82565723
43oxidative phosphorylation (GO:0006119)3.80423005
44IMP biosynthetic process (GO:0006188)3.79694587
45glycine metabolic process (GO:0006544)3.71106436
46translation (GO:0006412)3.67325237
47purine nucleoside triphosphate biosynthetic process (GO:0009145)3.65304629
48purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.64948407
49glyoxylate metabolic process (GO:0046487)3.59122288
50paraxial mesoderm development (GO:0048339)3.50044503
51hydrogen ion transmembrane transport (GO:1902600)3.47045872
52negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.46435267
53protein targeting to mitochondrion (GO:0006626)3.46333615
54protein complex disassembly (GO:0043241)3.43583567
55serine family amino acid metabolic process (GO:0009069)3.42620448
56protein neddylation (GO:0045116)3.40650095
57cysteine metabolic process (GO:0006534)3.39938900
58tryptophan catabolic process (GO:0006569)3.36989320
59indole-containing compound catabolic process (GO:0042436)3.36989320
60indolalkylamine catabolic process (GO:0046218)3.36989320
61ribonucleoside triphosphate biosynthetic process (GO:0009201)3.35581390
62inner mitochondrial membrane organization (GO:0007007)3.34811512
63cellular component biogenesis (GO:0044085)3.33146898
64establishment of protein localization to mitochondrion (GO:0072655)3.32045857
65macromolecular complex disassembly (GO:0032984)3.31293518
66aromatic amino acid family catabolic process (GO:0009074)3.28209370
67protein localization to mitochondrion (GO:0070585)3.24779390
68regulation of cellular amino acid metabolic process (GO:0006521)3.24280998
69ribonucleoprotein complex biogenesis (GO:0022613)3.23674450
70termination of RNA polymerase III transcription (GO:0006386)3.23616192
71transcription elongation from RNA polymerase III promoter (GO:0006385)3.23616192
72positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.23239827
73regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.22073249
74protein targeting to membrane (GO:0006612)3.21601697
75IMP metabolic process (GO:0046040)3.21145157
76respiratory chain complex IV assembly (GO:0008535)3.19765951
77cullin deneddylation (GO:0010388)3.19376889
78tryptophan metabolic process (GO:0006568)3.18521052
79L-ascorbic acid metabolic process (GO:0019852)3.17963062
80protein localization to chromosome, centromeric region (GO:0071459)3.17342097
81negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.16599802
82negative regulation of ligase activity (GO:0051352)3.16599802
83deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.15644242
84anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.14797362
85nucleoside triphosphate biosynthetic process (GO:0009142)3.12047870
86erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.10717543
87L-phenylalanine catabolic process (GO:0006559)3.10717543
88proteasome assembly (GO:0043248)3.04990955
89proton transport (GO:0015992)3.04227480
90CENP-A containing nucleosome assembly (GO:0034080)3.03988387
91glutathione derivative metabolic process (GO:1901685)3.03854362
92glutathione derivative biosynthetic process (GO:1901687)3.03854362
93erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.02163242
94L-phenylalanine metabolic process (GO:0006558)3.02163242
95mitochondrial transport (GO:0006839)3.02008601
96mitotic metaphase plate congression (GO:0007080)3.01920784
97imidazole-containing compound metabolic process (GO:0052803)2.99963081
98ribosome biogenesis (GO:0042254)2.99122714
99hydrogen transport (GO:0006818)2.98975580
100chromatin remodeling at centromere (GO:0031055)2.98580015
101phenylpropanoid metabolic process (GO:0009698)2.97548399
102spliceosomal snRNP assembly (GO:0000387)2.95283906
103regulation of cholesterol esterification (GO:0010872)2.94441468
104iron-sulfur cluster assembly (GO:0016226)2.93533232
105metallo-sulfur cluster assembly (GO:0031163)2.93533232
106polyamine biosynthetic process (GO:0006596)2.93441229
107purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.93039068
108purine nucleoside monophosphate biosynthetic process (GO:0009127)2.93039068
109GTP biosynthetic process (GO:0006183)2.93031884
110DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.92215921
111deoxyribose phosphate biosynthetic process (GO:0046385)2.91543573
1122-deoxyribonucleotide biosynthetic process (GO:0009265)2.91543573
113protein deneddylation (GO:0000338)2.91285856
114one-carbon compound transport (GO:0019755)2.90366190
115bile acid biosynthetic process (GO:0006699)2.89929031
116telomere maintenance via semi-conservative replication (GO:0032201)2.88379332
117cytochrome complex assembly (GO:0017004)2.88305192
118intracellular protein transmembrane import (GO:0044743)2.87767508
119high-density lipoprotein particle remodeling (GO:0034375)2.87626911
120positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.86426069
121signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.86412982
122signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.86412982
123signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.86412982
124protein-cofactor linkage (GO:0018065)2.85784893
125intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.85517991
126signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.85517991
127* glutathione metabolic process (GO:0006749)2.85468603
128DNA damage response, detection of DNA damage (GO:0042769)2.84252814
129regulation of cellular respiration (GO:0043457)2.83939304
130rRNA processing (GO:0006364)2.83330223
131nuclear-transcribed mRNA catabolic process (GO:0000956)2.82561498
132bile acid metabolic process (GO:0008206)2.81349710
133folic acid-containing compound biosynthetic process (GO:0009396)2.80790909
134serine family amino acid biosynthetic process (GO:0009070)2.80778656
135signal transduction involved in DNA integrity checkpoint (GO:0072401)2.79331366
136signal transduction involved in DNA damage checkpoint (GO:0072422)2.79331366
137rRNA modification (GO:0000154)2.75509970
138regulation of mitotic spindle checkpoint (GO:1903504)2.75059597
139regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.75059597
140kynurenine metabolic process (GO:0070189)2.74875625
141amine catabolic process (GO:0009310)2.74506577
142cellular biogenic amine catabolic process (GO:0042402)2.74506577
143amino-acid betaine metabolic process (GO:0006577)2.74477837
144signal transduction involved in cell cycle checkpoint (GO:0072395)2.74363720
145DNA strand elongation involved in DNA replication (GO:0006271)2.73501753
146aerobic respiration (GO:0009060)2.72814538
147positive regulation of ligase activity (GO:0051351)2.72543388
148rRNA metabolic process (GO:0016072)2.71074663
149flavonoid metabolic process (GO:0009812)2.70697253
150tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.69889825
151RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.69889825
152purine nucleobase biosynthetic process (GO:0009113)2.68083709
153mRNA catabolic process (GO:0006402)2.66985833
154galactose metabolic process (GO:0006012)2.66822160
155carnitine metabolic process (GO:0009437)2.66101576
156pseudouridine synthesis (GO:0001522)2.65475141
157deoxyribonucleotide biosynthetic process (GO:0009263)2.63107342
158DNA strand elongation (GO:0022616)2.61218986
159* regulation of cholesterol metabolic process (GO:0090181)2.60332931
160regulation of double-strand break repair via homologous recombination (GO:0010569)2.60139584
161energy homeostasis (GO:0097009)2.60053594
162urate metabolic process (GO:0046415)2.59495262
163mitotic sister chromatid segregation (GO:0000070)2.59190511
164metaphase plate congression (GO:0051310)2.58732394
165sulfur amino acid metabolic process (GO:0000096)2.56902367
166regulation of mitochondrial translation (GO:0070129)2.56677073
167histone H4-K12 acetylation (GO:0043983)2.56215965
168DNA replication initiation (GO:0006270)2.55986606
169ubiquinone metabolic process (GO:0006743)2.55904428
170nucleobase biosynthetic process (GO:0046112)2.55243029
171hormone catabolic process (GO:0042447)2.55214905
172misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.52793618
173pteridine-containing compound biosynthetic process (GO:0042559)2.52054551
174tetrahydrofolate metabolic process (GO:0046653)2.49533261
175triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.49167758
176heme metabolic process (GO:0042168)2.48302247
177nucleobase-containing small molecule interconversion (GO:0015949)2.48200587
178low-density lipoprotein particle remodeling (GO:0034374)2.47965366
179negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.46425293
180indolalkylamine metabolic process (GO:0006586)2.44829279
181DNA replication checkpoint (GO:0000076)2.44441447
182regulation of nuclear cell cycle DNA replication (GO:0033262)2.44254295
183NAD biosynthetic process (GO:0009435)2.43629251
184nucleoside diphosphate biosynthetic process (GO:0009133)2.43417889
185ethanol oxidation (GO:0006069)2.43394989
186water-soluble vitamin biosynthetic process (GO:0042364)2.42122023
187telomere maintenance via recombination (GO:0000722)2.41846610
188meiotic chromosome segregation (GO:0045132)2.41613352
189aromatic amino acid family metabolic process (GO:0009072)2.41548209

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.94607458
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.14822691
3* ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.14183906
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.64310268
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.96405599
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.86165520
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.85639473
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.85460505
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.76992766
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.69505814
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.62643792
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.62244124
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.53611701
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.53035722
15* PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.51474158
16AR_21909140_ChIP-Seq_LNCAP_Human2.42904237
17* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.40559248
18* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.31210568
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.22275930
20CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.21481927
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.17298536
22POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.16471364
23* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.13747401
24* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12939192
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.07974431
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.05768181
27FOXM1_23109430_ChIP-Seq_U2OS_Human2.05635909
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.05339354
29CREB1_15753290_ChIP-ChIP_HEK293T_Human2.00460975
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.99034279
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.86047216
32POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.85985711
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.85336234
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.83446014
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.78541940
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.77953164
37NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.77671425
38* XRN2_22483619_ChIP-Seq_HELA_Human1.77505537
39HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.74858181
40SOX2_18692474_ChIP-Seq_MEFs_Mouse1.73687648
41STAT3_1855785_ChIP-Seq_MESCs_Mouse1.68105606
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.67884498
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.65369731
44LXR_22158963_ChIP-Seq_LIVER_Mouse1.65090866
45TCF3_18692474_ChIP-Seq_MEFs_Mouse1.64318924
46NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.63200966
47KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.57643804
48KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.57643804
49KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.57643804
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.56927254
51SOX2_18555785_ChIP-Seq_MESCs_Mouse1.53676625
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.53498078
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53417062
54MYC_18940864_ChIP-ChIP_HL60_Human1.52613936
55ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.47734253
56FOXP3_21729870_ChIP-Seq_TREG_Human1.47640806
57ELK1_19687146_ChIP-ChIP_HELA_Human1.45253692
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43608183
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.42707258
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42126312
61YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41815343
62VDR_23849224_ChIP-Seq_CD4+_Human1.40569900
63IRF1_19129219_ChIP-ChIP_H3396_Human1.40412612
64SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.39049507
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35419317
66* TTF2_22483619_ChIP-Seq_HELA_Human1.35313971
67NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.35255813
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34729017
69CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.33485893
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31540155
71OCT4_18692474_ChIP-Seq_MEFs_Mouse1.31367070
72FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.29724395
73MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.29242538
74DCP1A_22483619_ChIP-Seq_HELA_Human1.28980512
75ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23583694
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.22552253
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21082008
78SALL1_21062744_ChIP-ChIP_HESCs_Human1.19273871
79* EGR1_19374776_ChIP-ChIP_THP-1_Human1.18537747
80* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.18280666
81NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.18209068
82KDM5A_27292631_Chip-Seq_BREAST_Human1.18087768
83SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17623801
84NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.17412991
85THAP11_20581084_ChIP-Seq_MESCs_Mouse1.16021404
86NANOG_18692474_ChIP-Seq_MEFs_Mouse1.14772092
87SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14264881
88TCF3_18692474_ChIP-Seq_MESCs_Mouse1.13501475
89FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12027200
90ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11678703
91* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09020251
92* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08249949
93SOX2_18692474_ChIP-Seq_MESCs_Mouse1.08061526
94GABP_19822575_ChIP-Seq_HepG2_Human1.06189278
95RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05255476
96SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05016376
97* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04696653
98VDR_22108803_ChIP-Seq_LS180_Human1.03081584
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01791533
100ELK1_22589737_ChIP-Seq_MCF10A_Human0.99764332
101* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98977133
102HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98464072
103FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98232707
104DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97791674
105TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97232171
106KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97115781
107FUS_26573619_Chip-Seq_HEK293_Human0.96572302
108CTCF_18555785_ChIP-Seq_MESCs_Mouse0.94935060
109* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92869811
110KAP1_22055183_ChIP-Seq_ESCs_Mouse0.91775666
111NANOG_16153702_ChIP-ChIP_HESCs_Human0.91675155
112POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.91042815
113SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89234941
114ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88421664
115EWS_26573619_Chip-Seq_HEK293_Human0.88179208
116SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.83331166
117SOX2_16153702_ChIP-ChIP_HESCs_Human0.82983861
118E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.81294606
119CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.81039923
120HTT_18923047_ChIP-ChIP_STHdh_Human0.79565751
121FOXP1_21924763_ChIP-Seq_HESCs_Human0.77006541
122* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.76035878
123FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.75904330
124ZNF263_19887448_ChIP-Seq_K562_Human0.75788875
125CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.75700513
126IGF1R_20145208_ChIP-Seq_DFB_Human0.75649222
127* SOX17_20123909_ChIP-Seq_XEN_Mouse0.74993642
128* TP53_22573176_ChIP-Seq_HFKS_Human0.71373918
129TBX5_21415370_ChIP-Seq_HL-1_Mouse0.69235118
130BMI1_23680149_ChIP-Seq_NPCS_Mouse0.69100586
131CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.68944988

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.75532298
2MP0008875_abnormal_xenobiotic_pharmacok4.74358064
3MP0003806_abnormal_nucleotide_metabolis4.24924063
4MP0008789_abnormal_olfactory_epithelium4.12603388
5MP0005394_taste/olfaction_phenotype3.91280728
6MP0005499_abnormal_olfactory_system3.91280728
7MP0009379_abnormal_foot_pigmentation3.91180625
8MP0005085_abnormal_gallbladder_physiolo3.51004227
9MP0002653_abnormal_ependyma_morphology3.46305438
10* MP0003186_abnormal_redox_activity3.24474432
11MP0005360_urolithiasis3.06240160
12MP0003136_yellow_coat_color2.79888518
13MP0003693_abnormal_embryo_hatching2.78523873
14MP0000372_irregular_coat_pigmentation2.76711489
15MP0005365_abnormal_bile_salt2.75788902
16MP0003880_abnormal_central_pattern2.34777266
17MP0005408_hypopigmentation2.21817910
18MP0001529_abnormal_vocalization2.17035476
19MP0002938_white_spotting2.09755311
20MP0000566_synostosis2.02200324
21MP0009053_abnormal_anal_canal1.94505985
22MP0009046_muscle_twitch1.88673772
23MP0001984_abnormal_olfaction1.84221664
24MP0010030_abnormal_orbit_morphology1.83647880
25MP0003718_maternal_effect1.83432701
26MP0008007_abnormal_cellular_replicative1.77966079
27MP0002877_abnormal_melanocyte_morpholog1.72857770
28MP0002132_abnormal_respiratory_system1.69995745
29MP0003111_abnormal_nucleus_morphology1.66785044
30MP0003786_premature_aging1.62546305
31MP0005647_abnormal_sex_gland1.60015001
32MP0010094_abnormal_chromosome_stability1.59096852
33MP0003191_abnormal_cellular_cholesterol1.58671625
34MP0006035_abnormal_mitochondrial_morpho1.58174450
35MP0010329_abnormal_lipoprotein_level1.57052409
36MP0004957_abnormal_blastocyst_morpholog1.52307485
37MP0002272_abnormal_nervous_system1.52204936
38MP0009697_abnormal_copulation1.51510493
39MP0003011_delayed_dark_adaptation1.50967500
40MP0006292_abnormal_olfactory_placode1.48601426
41MP0005377_hearing/vestibular/ear_phenot1.47016072
42MP0003878_abnormal_ear_physiology1.47016072
43MP0003077_abnormal_cell_cycle1.46720032
44MP0002736_abnormal_nociception_after1.45254806
45MP0002138_abnormal_hepatobiliary_system1.44365975
46MP0005171_absent_coat_pigmentation1.41950401
47MP0000678_abnormal_parathyroid_gland1.41838460
48MP0003315_abnormal_perineum_morphology1.40757286
49MP0004782_abnormal_surfactant_physiolog1.40003563
50MP0001905_abnormal_dopamine_level1.39804444
51MP0006072_abnormal_retinal_apoptosis1.39582370
52MP0004019_abnormal_vitamin_homeostasis1.38220194
53MP0002064_seizures1.34147244
54MP0004142_abnormal_muscle_tone1.33221413
55MP0005332_abnormal_amino_acid1.32226131
56* MP0009745_abnormal_behavioral_response1.31965379
57MP0001764_abnormal_homeostasis1.29360237
58MP0001485_abnormal_pinna_reflex1.24844920
59MP0002638_abnormal_pupillary_reflex1.22793232
60MP0003195_calcinosis1.21765733
61MP0004742_abnormal_vestibular_system1.21707543
62MP0005551_abnormal_eye_electrophysiolog1.20520202
63MP0000613_abnormal_salivary_gland1.19915478
64MP0002160_abnormal_reproductive_system1.19693923
65MP0002009_preneoplasia1.19093830
66MP0000049_abnormal_middle_ear1.19048086
67MP0003123_paternal_imprinting1.17822376
68MP0008058_abnormal_DNA_repair1.17302855
69MP0001293_anophthalmia1.17233445
70MP0005187_abnormal_penis_morphology1.15432939
71MP0002822_catalepsy1.15256394
72MP0000516_abnormal_urinary_system1.15023601
73MP0005367_renal/urinary_system_phenotyp1.15023601
74MP0009840_abnormal_foam_cell1.14623616
75MP0002095_abnormal_skin_pigmentation1.13861381
76MP0003252_abnormal_bile_duct1.13093322
77MP0002837_dystrophic_cardiac_calcinosis1.12986039
78MP0009672_abnormal_birth_weight1.12703890
79MP0010368_abnormal_lymphatic_system1.12458909
80MP0005266_abnormal_metabolism1.11636874
81MP0006276_abnormal_autonomic_nervous1.11621032
82MP0005646_abnormal_pituitary_gland1.11366033
83MP0003941_abnormal_skin_development1.11106385
84MP0005423_abnormal_somatic_nervous1.09764444
85MP0002751_abnormal_autonomic_nervous1.09134469
86MP0001968_abnormal_touch/_nociception1.07937458
87MP0001188_hyperpigmentation1.07693016
88MP0002102_abnormal_ear_morphology1.06605118
89MP0002090_abnormal_vision1.05169260
90MP0008995_early_reproductive_senescence1.03496600
91* MP0002210_abnormal_sex_determination1.02967850
92MP0002233_abnormal_nose_morphology1.00240888
93MP0002234_abnormal_pharynx_morphology1.00039169
94MP0005084_abnormal_gallbladder_morpholo0.98666655
95MP0003635_abnormal_synaptic_transmissio0.97054144
96MP0005253_abnormal_eye_physiology0.96156862
97MP0002557_abnormal_social/conspecific_i0.95542227
98MP0001929_abnormal_gametogenesis0.94268173
99* MP0001119_abnormal_female_reproductive0.93892062
100MP0000631_abnormal_neuroendocrine_gland0.93731207
101MP0002734_abnormal_mechanical_nocicepti0.92866021
102MP0002572_abnormal_emotion/affect_behav0.92525929
103MP0005197_abnormal_uvea_morphology0.92458102
104* MP0005319_abnormal_enzyme/_coenzyme0.91934864
105MP0002067_abnormal_sensory_capabilities0.91727167
106MP0001919_abnormal_reproductive_system0.91294986
107MP0004859_abnormal_synaptic_plasticity0.91077503
108MP0001666_abnormal_nutrient_absorption0.89906240
109MP0005379_endocrine/exocrine_gland_phen0.89549300
110MP0006036_abnormal_mitochondrial_physio0.88779715
111MP0008057_abnormal_DNA_replication0.87880417
112MP0001486_abnormal_startle_reflex0.87822703
113MP0008932_abnormal_embryonic_tissue0.86635009
114* MP0000350_abnormal_cell_proliferation0.86553561
115* MP0009765_abnormal_xenobiotic_induced0.86435409
116MP0004885_abnormal_endolymph0.85863171
117MP0010386_abnormal_urinary_bladder0.84718459
118MP0002163_abnormal_gland_morphology0.84559920
119MP0000609_abnormal_liver_physiology0.84139018
120MP0003698_abnormal_male_reproductive0.84061886
121MP0001324_abnormal_eye_pigmentation0.83313106
122MP0001145_abnormal_male_reproductive0.82010821
123MP0005083_abnormal_biliary_tract0.81158078
124MP0005389_reproductive_system_phenotype0.80381781
125MP0003119_abnormal_digestive_system0.79716065
126MP0002063_abnormal_learning/memory/cond0.78476918
127MP0000358_abnormal_cell_content/0.78186799
128MP0004270_analgesia0.77823187
129MP0003122_maternal_imprinting0.77804657
130* MP0000653_abnormal_sex_gland0.77794144
131MP0000598_abnormal_liver_morphology0.77114125
132MP0001672_abnormal_embryogenesis/_devel0.75698919
133MP0005380_embryogenesis_phenotype0.75698919
134MP0001730_embryonic_growth_arrest0.75472551
135MP0005376_homeostasis/metabolism_phenot0.73933555
136MP0005584_abnormal_enzyme/coenzyme_acti0.73168516
137MP0009643_abnormal_urine_homeostasis0.73000444
138MP0000490_abnormal_crypts_of0.72008929
139MP0008877_abnormal_DNA_methylation0.71151315
140MP0002118_abnormal_lipid_homeostasis0.70665058
141* MP0000313_abnormal_cell_death0.70513366
142MP0005636_abnormal_mineral_homeostasis0.69529821
143MP0005248_abnormal_Harderian_gland0.69312731
144MP0001915_intracranial_hemorrhage0.68943392
145MP0000762_abnormal_tongue_morphology0.66150000
146MP0005395_other_phenotype0.66064650
147MP0001177_atelectasis0.65571175
148MP0005075_abnormal_melanosome_morpholog0.64932085
149MP0008872_abnormal_physiological_respon0.63320581
150MP0003567_abnormal_fetal_cardiomyocyte0.63064987
151MP0002111_abnormal_tail_morphology0.62880999
152MP0004808_abnormal_hematopoietic_stem0.62236925
153MP0003942_abnormal_urinary_system0.61394961
154MP0002098_abnormal_vibrissa_morphology0.58775837
155MP0004197_abnormal_fetal_growth/weight/0.57823188
156MP0004147_increased_porphyrin_level0.57564324
157MP0002876_abnormal_thyroid_physiology0.57553604

Predicted human phenotypes

RankGene SetZ-score
1Progressive macrocephaly (HP:0004481)4.97563170
2Increased hepatocellular lipid droplets (HP:0006565)4.50305649
3Hyperglycinuria (HP:0003108)4.42966449
4Lipid accumulation in hepatocytes (HP:0006561)4.07312220
5Intrahepatic cholestasis (HP:0001406)3.97119983
6Hyperglycinemia (HP:0002154)3.89907469
7Abnormality of monocarboxylic acid metabolism (HP:0010996)3.85380219
8Osteomalacia (HP:0002749)3.83877599
9Reticulocytopenia (HP:0001896)3.76149877
10Macrocytic anemia (HP:0001972)3.75638964
11Renal Fanconi syndrome (HP:0001994)3.72146825
12Increased intramyocellular lipid droplets (HP:0012240)3.71694757
13Vaginal fistula (HP:0004320)3.68752939
14Renal tubular acidosis (HP:0001947)3.65613470
15Abnormality of cells of the erythroid lineage (HP:0012130)3.63223947
16Abnormal number of erythroid precursors (HP:0012131)3.53272235
17Myokymia (HP:0002411)3.31159283
18Abnormality of aromatic amino acid family metabolism (HP:0004338)3.23362182
19Abnormality of glycine metabolism (HP:0010895)3.21565248
20Abnormality of serine family amino acid metabolism (HP:0010894)3.21565248
21Rectal fistula (HP:0100590)3.15776480
22Rectovaginal fistula (HP:0000143)3.15776480
233-Methylglutaconic aciduria (HP:0003535)3.12907131
24Hypobetalipoproteinemia (HP:0003563)3.10643452
25Increased muscle lipid content (HP:0009058)3.07739312
26Increased serum pyruvate (HP:0003542)3.07657392
27Renal tubular dysfunction (HP:0000124)3.06592911
28Impulsivity (HP:0100710)3.06461913
29Stenosis of the external auditory canal (HP:0000402)3.05565990
30Leukodystrophy (HP:0002415)3.04867821
31Exercise intolerance (HP:0003546)3.04462493
32Respiratory failure (HP:0002878)3.01404861
33Abnormality of glycolysis (HP:0004366)2.98105826
34Abnormality of pyrimidine metabolism (HP:0004353)2.80078813
35Intestinal fistula (HP:0100819)2.77530170
36Carpal bone hypoplasia (HP:0001498)2.74256746
37Renal cortical cysts (HP:0000803)2.68867332
38Optic disc pallor (HP:0000543)2.60788115
39Conjugated hyperbilirubinemia (HP:0002908)2.56644781
40Birth length less than 3rd percentile (HP:0003561)2.54880836
41Fat malabsorption (HP:0002630)2.52447158
42Glycosuria (HP:0003076)2.50399876
43Abnormality of urine glucose concentration (HP:0011016)2.50399876
44Abnormality of the 1st metacarpal (HP:0010009)2.48844775
45Hyperbilirubinemia (HP:0002904)2.47602596
46Prolonged partial thromboplastin time (HP:0003645)2.47208592
47Exertional dyspnea (HP:0002875)2.47141371
48Hepatic necrosis (HP:0002605)2.47035011
49Abnormality of methionine metabolism (HP:0010901)2.41627297
50Prolonged neonatal jaundice (HP:0006579)2.39980180
51Respiratory difficulties (HP:0002880)2.39974709
52Short 1st metacarpal (HP:0010034)2.39633115
53Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.39633115
54Steatorrhea (HP:0002570)2.37305455
55Hyperphosphaturia (HP:0003109)2.36087922
56Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.34677669
57Rib fusion (HP:0000902)2.34386733
58Pallor (HP:0000980)2.33916530
59Deep venous thrombosis (HP:0002625)2.33770515
60Abnormality of fatty-acid metabolism (HP:0004359)2.32658915
61Abnormal hemoglobin (HP:0011902)2.32091748
62Lethargy (HP:0001254)2.31574731
63Cerebral edema (HP:0002181)2.30854139
64Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.29278260
65Lip pit (HP:0100267)2.29199707
66Generalized aminoaciduria (HP:0002909)2.28208528
67Hypoglycemic coma (HP:0001325)2.26254196
68Abnormality of renal resorption (HP:0011038)2.26179395
69CNS demyelination (HP:0007305)2.26111338
70Breast hypoplasia (HP:0003187)2.24594662
71Hyperammonemia (HP:0001987)2.24583639
72Hepatocellular carcinoma (HP:0001402)2.23568472
73Abnormality of aspartate family amino acid metabolism (HP:0010899)2.21905764
74X-linked dominant inheritance (HP:0001423)2.21674885
75Aplasia/Hypoplasia of the patella (HP:0006498)2.19591649
76Nausea (HP:0002018)2.19122245
77Abnormality of serum amino acid levels (HP:0003112)2.18294664
78Proximal tubulopathy (HP:0000114)2.17719888
79Abnormality of transition element cation homeostasis (HP:0011030)2.17678286
80Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.17484475
81Aplasia/Hypoplasia of the sacrum (HP:0008517)2.15245355
82Pulmonary artery stenosis (HP:0004415)2.15206332
83Emotional lability (HP:0000712)2.14488280
84Hypolipoproteinemia (HP:0010981)2.14134495
85Abnormality of alanine metabolism (HP:0010916)2.13537892
86Hyperalaninemia (HP:0003348)2.13537892
87Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13537892
88Joint hemorrhage (HP:0005261)2.13128132
89Opisthotonus (HP:0002179)2.11587486
9011 pairs of ribs (HP:0000878)2.10236461
91Abnormality of glutamine family amino acid metabolism (HP:0010902)2.09664869
92Abnormality of nucleobase metabolism (HP:0010932)2.08672548
93Pancreatic fibrosis (HP:0100732)2.08432812
94Cerebral hypomyelination (HP:0006808)2.08377217
95Acute encephalopathy (HP:0006846)2.06758224
96Type I transferrin isoform profile (HP:0003642)2.05065288
97Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.04998152
98Carpal synostosis (HP:0009702)2.03732200
99Methylmalonic aciduria (HP:0012120)2.03059341
100Abnormality of sulfur amino acid metabolism (HP:0004339)2.02666011
101Abnormality of the heme biosynthetic pathway (HP:0010472)2.02370923
102Methylmalonic acidemia (HP:0002912)2.01951721
103Hepatocellular necrosis (HP:0001404)1.96992826
104Brushfield spots (HP:0001088)1.96618032
105Decreased activity of mitochondrial respiratory chain (HP:0008972)1.96072724
106Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.96072724
107Abnormal respiratory motile cilium physiology (HP:0012261)1.96044226
108Anomalous pulmonary venous return (HP:0010772)1.94729683
109Increased CSF lactate (HP:0002490)1.94437452
110Microvesicular hepatic steatosis (HP:0001414)1.93964150
111Hypercholesterolemia (HP:0003124)1.93961008
112Acute necrotizing encephalopathy (HP:0006965)1.93588796
113Increased serum lactate (HP:0002151)1.93081003
114Alveolar cell carcinoma (HP:0006519)1.92955506
115Medial flaring of the eyebrow (HP:0010747)1.92209129
116Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.90889431
117Gout (HP:0001997)1.88914016
118Megaloblastic anemia (HP:0001889)1.88715293
119Lactic acidosis (HP:0003128)1.88658627
120Abnormal urine phosphate concentration (HP:0012599)1.85380537
121Long foot (HP:0001833)1.85380195
122Abnormal lung lobation (HP:0002101)1.84975550
123Optic nerve coloboma (HP:0000588)1.84870285
124Syringomyelia (HP:0003396)1.84058100
125Spinal cord lesions (HP:0100561)1.84058100
126Poor suck (HP:0002033)1.83636433
127Abnormality of cochlea (HP:0000375)1.83145556
128Mitochondrial inheritance (HP:0001427)1.81466761
129Thyroid carcinoma (HP:0002890)1.81278858
130Hemivertebrae (HP:0002937)1.80965345
131Microretrognathia (HP:0000308)1.80007224
132True hermaphroditism (HP:0010459)1.79182585
133Hyperlipoproteinemia (HP:0010980)1.78750664
134Redundant skin (HP:0001582)1.78627203
135Abnormal mitochondria in muscle tissue (HP:0008316)1.78421137
136Oral leukoplakia (HP:0002745)1.77582601
137Hypertriglyceridemia (HP:0002155)1.77081728
138Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.76600175
139Rhinitis (HP:0012384)1.76497401
140Molar tooth sign on MRI (HP:0002419)1.76356854
141Abnormality of midbrain morphology (HP:0002418)1.76356854
142Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.76106894
143Focal motor seizures (HP:0011153)1.75868741
144Esophageal varix (HP:0002040)1.75775174
145Synostosis of carpal bones (HP:0005048)1.75692934
146Xanthomatosis (HP:0000991)1.75604682
147Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.75294567
148Gait imbalance (HP:0002141)1.74563434
149Aplastic anemia (HP:0001915)1.72711160
150CNS hypomyelination (HP:0003429)1.70773588
151Pancreatic cysts (HP:0001737)1.70625813
152Testicular atrophy (HP:0000029)1.70507890
153Congenital primary aphakia (HP:0007707)1.69899267
154Delayed CNS myelination (HP:0002188)1.67680243
155Sclerocornea (HP:0000647)1.67672582
156Abnormal ciliary motility (HP:0012262)1.65963625
157Dicarboxylic aciduria (HP:0003215)1.65525613
158Abnormality of dicarboxylic acid metabolism (HP:0010995)1.65525613
159Reduced antithrombin III activity (HP:0001976)1.64901736
160Blindness (HP:0000618)1.64752224
161Vomiting (HP:0002013)1.64048458
162Metabolic acidosis (HP:0001942)1.62440188
163Abnormal respiratory epithelium morphology (HP:0012253)1.60894550
164Abnormal respiratory motile cilium morphology (HP:0005938)1.60894550
165Pancytopenia (HP:0001876)1.60538308
166Abnormality of the labia minora (HP:0012880)1.60401620
167Abnormality of reticulocytes (HP:0004312)1.58054571
168Aplasia/hypoplasia of the uterus (HP:0008684)1.57948507

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK14.67103127
2ZAK3.56189707
3MKNK23.44346310
4SRPK13.35666382
5VRK23.29061397
6EIF2AK23.08670382
7BCKDK2.88300900
8CDC72.86159001
9MAP3K122.69879835
10ERBB32.36871222
11NME12.18071440
12STK38L2.13873955
13PDK22.00046164
14AURKA1.92363036
15SGK21.91735653
16PNCK1.90602774
17AKT31.79845657
18MAP3K141.78257204
19EIF2AK11.75107575
20PASK1.70364334
21PLK31.68435587
22RPS6KA41.67848806
23STK41.59706492
24WEE11.57575703
25NME21.57088892
26STK241.52249177
27MAP2K31.50602749
28RPS6KB21.47991292
29BUB11.47263708
30VRK11.47240408
31ARAF1.43970214
32BMPR21.39468663
33SCYL21.32333039
34BRSK11.30649636
35MAP3K31.29693297
36PLK11.28949516
37DYRK21.28688473
38NEK11.27349879
39WNK41.24833577
40EIF2AK31.23185262
41IKBKE1.22201390
42STK161.17788676
43WNK31.15868710
44PBK1.14397933
45TLK11.13195728
46EPHA41.12440516
47CCNB11.09694786
48ADRBK21.09350078
49CSNK1G31.09320282
50TRIM281.09162604
51CSNK1G21.07987642
52NEK21.07292809
53PIM11.06386985
54FRK1.06104830
55SGK4941.05872142
56SGK2231.05872142
57SGK31.05447776
58PLK41.04909392
59NEK61.03537974
60CHEK21.02390713
61LIMK11.01934302
62EPHA21.01668252
63TTK0.99819422
64MAP4K20.98379112
65AURKB0.97686888
66MINK10.96753616
67TESK10.95536144
68PRKCG0.95044246
69BRSK20.94346385
70CDK60.91094242
71STK390.90933397
72BRAF0.90244380
73CDK190.89875681
74MYLK0.89544766
75CSNK1G10.87582388
76BMPR1B0.87119787
77TIE10.86898766
78MST1R0.85100367
79MAP2K70.84448450
80CSNK2A10.83815910
81PIM20.83769159
82TSSK60.83678022
83TEC0.83340758
84CDK70.82585287
85MST40.78887103
86CASK0.78420449
87ATR0.78200338
88CHUK0.75305056
89NTRK30.74020620
90TAF10.72841591
91MAPKAPK50.72443495
92IKBKB0.72440970
93MAP2K60.70719570
94ERBB40.69642313
95MAP2K20.69337905
96CSNK1A1L0.68751922
97CDK80.68733858
98DAPK10.68465022
99ILK0.68257202
100MAP3K40.67416167
101ACVR1B0.67245654
102ABL20.66542463
103IRAK40.65981243
104CSNK2A20.65533932
105TGFBR10.65221215
106TNIK0.65042098
107CDK140.64907125
108KDR0.64560300
109UHMK10.64520942
110JAK30.64494785
111PRKCI0.64264534
112RPS6KA50.63878700
113CAMK2G0.63821651
114GRK50.62378175
115FLT30.62092596
116CSNK1E0.61683743
117MAPK150.61067152
118MAP3K90.61045611
119CDK11A0.60163903
120FGFR30.59622904
121OXSR10.58804080
122PHKG20.58495509
123PHKG10.58495509
124CDK180.57636854
125CDK150.57626425
126MAPKAPK30.56371882
127MARK10.56346529
128EPHB20.56099180
129NUAK10.56048925
130BCR0.55747542
131PAK30.54181924
132CAMK2D0.52782195
133PAK60.51983229
134PLK20.51828027
135CAMK2A0.50942007
136DAPK30.50375538
137RPS6KL10.49608092
138RPS6KC10.49608092
139PINK10.49585940
140RPS6KB10.49437033
141MAP3K80.48991652
142TRPM70.48694758
143LRRK20.47187816
144CDK40.46534377
145RPS6KA60.46324099
146DYRK30.45721222
147NEK90.44986661
148YES10.44727314
149MAP3K110.43220700
150MAP2K10.41428435
151PIK3CG0.40527161
152CDK30.39576726
153CDK20.39555528
154STK100.39343968
155CHEK10.38360502
156MAPKAPK20.36966373
157OBSCN0.36875778
158GRK10.35467214
159MAPK30.34511659

Predicted pathways (KEGG)

RankGene SetZ-score
1Pentose and glucuronate interconversions_Homo sapiens_hsa000403.68103264
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.58775181
3Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.91935983
4Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.91705394
5Chemical carcinogenesis_Homo sapiens_hsa052042.63417495
6Drug metabolism - other enzymes_Homo sapiens_hsa009832.54229581
7Sulfur metabolism_Homo sapiens_hsa009202.52586438
8One carbon pool by folate_Homo sapiens_hsa006702.42829940
9Sulfur relay system_Homo sapiens_hsa041222.32251131
10Protein export_Homo sapiens_hsa030602.32129320
11Steroid hormone biosynthesis_Homo sapiens_hsa001402.30611453
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.30138908
13Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.28644864
14DNA replication_Homo sapiens_hsa030302.12041135
15Selenocompound metabolism_Homo sapiens_hsa004502.06595632
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.01867453
17Cardiac muscle contraction_Homo sapiens_hsa042601.88616177
18Glutathione metabolism_Homo sapiens_hsa004801.82530337
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.78491782
20Mismatch repair_Homo sapiens_hsa034301.76617414
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.75694828
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.74828254
23Proteasome_Homo sapiens_hsa030501.72026144
24* Peroxisome_Homo sapiens_hsa041461.64353452
25Butanoate metabolism_Homo sapiens_hsa006501.64107216
26Retinol metabolism_Homo sapiens_hsa008301.63322730
27Starch and sucrose metabolism_Homo sapiens_hsa005001.59478415
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.54536763
29Tryptophan metabolism_Homo sapiens_hsa003801.54502792
30Ribosome_Homo sapiens_hsa030101.48042580
31Fatty acid degradation_Homo sapiens_hsa000711.46836563
32Homologous recombination_Homo sapiens_hsa034401.43889077
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.37069605
34beta-Alanine metabolism_Homo sapiens_hsa004101.36720251
35Pyrimidine metabolism_Homo sapiens_hsa002401.36137360
36Caffeine metabolism_Homo sapiens_hsa002321.33919719
37Galactose metabolism_Homo sapiens_hsa000521.32509240
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.31097176
39Vitamin B6 metabolism_Homo sapiens_hsa007501.30311177
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29976440
41Phenylalanine metabolism_Homo sapiens_hsa003601.29177975
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.28540090
43Base excision repair_Homo sapiens_hsa034101.25984788
44RNA polymerase_Homo sapiens_hsa030201.20090320
45Propanoate metabolism_Homo sapiens_hsa006401.19928822
46Folate biosynthesis_Homo sapiens_hsa007901.18130086
47Tyrosine metabolism_Homo sapiens_hsa003501.10848800
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05215907
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03706229
50Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.03441587
51Oxidative phosphorylation_Homo sapiens_hsa001901.03414859
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01530075
53Complement and coagulation cascades_Homo sapiens_hsa046101.00744390
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.98534556
55Parkinsons disease_Homo sapiens_hsa050120.96035766
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96001233
57Non-homologous end-joining_Homo sapiens_hsa034500.95861184
58Histidine metabolism_Homo sapiens_hsa003400.95593845
59Carbon metabolism_Homo sapiens_hsa012000.94053959
60Nucleotide excision repair_Homo sapiens_hsa034200.93422827
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.93017479
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87644912
63Fatty acid elongation_Homo sapiens_hsa000620.87497869
64Basal transcription factors_Homo sapiens_hsa030220.85592730
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85575840
66Collecting duct acid secretion_Homo sapiens_hsa049660.84543228
67Arginine biosynthesis_Homo sapiens_hsa002200.82915667
68RNA transport_Homo sapiens_hsa030130.81733444
69Pyruvate metabolism_Homo sapiens_hsa006200.81582267
70Spliceosome_Homo sapiens_hsa030400.81414147
71Fatty acid metabolism_Homo sapiens_hsa012120.81106625
72RNA degradation_Homo sapiens_hsa030180.78398518
73Biosynthesis of amino acids_Homo sapiens_hsa012300.78147082
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.75097488
75Huntingtons disease_Homo sapiens_hsa050160.73977072
76Nicotine addiction_Homo sapiens_hsa050330.72867054
77Fanconi anemia pathway_Homo sapiens_hsa034600.72344941
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72179928
79Arginine and proline metabolism_Homo sapiens_hsa003300.71175286
80Metabolic pathways_Homo sapiens_hsa011000.70693159
81Cell cycle_Homo sapiens_hsa041100.69159890
82PPAR signaling pathway_Homo sapiens_hsa033200.64649574
83Thyroid cancer_Homo sapiens_hsa052160.64061740
84Pentose phosphate pathway_Homo sapiens_hsa000300.60981475
85Bile secretion_Homo sapiens_hsa049760.60582116
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59319572
87Purine metabolism_Homo sapiens_hsa002300.58097538
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57622531
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.57126315
90Fat digestion and absorption_Homo sapiens_hsa049750.55664611
91Synaptic vesicle cycle_Homo sapiens_hsa047210.55167441
92Steroid biosynthesis_Homo sapiens_hsa001000.53633511
93Fructose and mannose metabolism_Homo sapiens_hsa000510.52567225
94Arachidonic acid metabolism_Homo sapiens_hsa005900.52530095
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50756666
96ABC transporters_Homo sapiens_hsa020100.50109136
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44382992
98Oocyte meiosis_Homo sapiens_hsa041140.43221099
99Linoleic acid metabolism_Homo sapiens_hsa005910.42262899
100Phototransduction_Homo sapiens_hsa047440.39820245
101p53 signaling pathway_Homo sapiens_hsa041150.38928948
102Alzheimers disease_Homo sapiens_hsa050100.36096749
103mRNA surveillance pathway_Homo sapiens_hsa030150.34789343
104Vibrio cholerae infection_Homo sapiens_hsa051100.33840102
105Nitrogen metabolism_Homo sapiens_hsa009100.32985122
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31009918
107Systemic lupus erythematosus_Homo sapiens_hsa053220.30955758
108N-Glycan biosynthesis_Homo sapiens_hsa005100.29554557
109GABAergic synapse_Homo sapiens_hsa047270.28964702
110Mineral absorption_Homo sapiens_hsa049780.27373497
111Glycerolipid metabolism_Homo sapiens_hsa005610.25342466
112Staphylococcus aureus infection_Homo sapiens_hsa051500.23861711
113Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.23669603
114Vitamin digestion and absorption_Homo sapiens_hsa049770.21232953
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18261816
116Regulation of autophagy_Homo sapiens_hsa041400.16845522

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